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TDMS Study 05142-03 Pathology Tables

NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97
Route: DOSED WATER                                                                                                Time: 14:52:32




       Facility:  Southern Research Institute

       Chemical CAS #:  75-65-0

       Lock Date:  01/10/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|             
                                           | 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                    X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Parasite Metazoan                    |    X                    X  X     X     X           X     X              X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                     3                                    |             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                     2                                    |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              3                          2|             
      Basophilic Focus                     | X  X  X     X        X  X        X     X     X  X  X  X  X  X  X  X     X|             
      Clear Cell Focus                     |                                                                X     X   |             
      Granuloma                            | 3     1     2              1                       1                 2   |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Hepatodiaphragmatic Nodule           |    X  X                 X  X  X     X                 X                  |             
      Hyperplasia, Focal                   |                      4                       3  3                        |             
      Hyperplasia, Lymphoid                | 2  1        1                                                            |             
      Inflammation, Subacute               |                                                    1     1        1      |             
      Mixed Cell Focus                     |       X                                                                  |             
      Bile Duct, Cyst                      |                         X                       X                        |             
      Bile Duct, Hyperplasia               |                   2  2  3              1                       1        1|             
      Centrilobular, Atrophy               |                         2                    2                           |             
      Hepatocyte, Vacuolization Cytoplasmic|          3        3                       2                          3   |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |                               3                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                        +               |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        | 1                                                        2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                             2  2           2  1           1        1  1|             
      Acinar Cell, Cytoplasmic Alteration  |                               3                       3              3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Acinar Cell, Cytoplasmic Alteration  |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                2   |             
      Erosion                              |                                     1                                    |             
      Inflammation, Subacute               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|             
                                           | 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                               3                                      3   |             
      Mucosa, Hyperplasia                  |                                     2           2                    1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Edema                                |                                                                          |             
      Erosion                              |          1                                1  1                       3   |             
      Ulcer                                |                                                                          |             
      Epithelium, Dilatation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     1                       2              1              1  1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         X  X                 X                           |             
      Angiectasis                          |                            2                       2                     |             
      Atrophy                              |                         3                                                |             
      Basophilic Focus                     |                                                                X         |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hyperplasia, Focal                   |       1                                                                 1|             
      Hypertrophy, Focal                   |                                                                          |             
      Metaplasia, Osseous                  |                         2                                                |             
      Necrosis                             |                                                                      3   |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |    1                                      1     3                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Angiectasis           |          3                       3     3  2  2              2            |             
      Pars Distalis, Atrophy               |                                                                          |             
      Pars Distalis, Cyst                  | X  X           X           X     X  X     X  X     X  X  X  X     X      |             
      Pars Distalis, Hyperplasia           |    2                             3     1  3        2  2     1     2      |             
      Pars Intermedia, Angiectasis         |             2                                                            |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|             
                                           | 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  | 1                          2     2     1  1     1           1  1        1|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 4                                                                        |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 3     2                                                  1     1         |             
      Inflammation, Suppurative            | 3                                                                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X        X                 X        X        X           X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                              2                           |             
      Hyperplasia, Cystic                  |       1                                                                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                    M                    +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                    1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +        +     +     +     +     +  +                           |             
      Mediastinal, Hemorrhage              |                                     1                                    |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |    2           3                 2                                       |             
      Hyperplasia, Plasma Cell             |    2                 2           2                                       |             
      Pigmentation                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |       3           3                                                      |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|             
                                           | 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                3                                                         |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                         3                 2                              |             
      Hematopoietic Cell Proliferation     | 2  2              3  2  2        2                          2            |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                               3                                          |             
      Pigmentation                         |    3  3     3  3           3  3  3  2           3  2  2  2  2  2  2  3  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       3  2  3  1  1  2  2     2  1        3  2        2  1  2        1  2|             
      Hyperplasia, Lobular                 |                                  3              1        1               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                             2            |             
      Exudate                              |                                                             X            |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteopetrosis             |    2  3  3        3              2           3        2  2  2           2|             
      Femur, Osteopetrosis                 | 2                 3              2                    2  2               |             
      Sternum, Osteopetrosis               | 2  2              3              2                       2               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X                 X                       X                    X  X|             
      Developmental Malformation           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |             1                                                            |             
      Infiltration Cellular, Histiocyte    |    1  1              1     1     2              1        1  1            |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|             
                                           | 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                               X                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |    X                                X        X        X              X   |             
      Foreign Body                         |                                              2                           |             
      Fungus                               |    X                                X                 X                  |             
      Glands, Hyperplasia                  |                                                                          |             
      Mucosa, Hyperplasia                  |    3           2                    3        2  1     2                  |             
      Mucosa, Metaplasia, Squamous         |    2                                2                 2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                         2|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 3  3  2     3  3  3  2  3  3  2  3  3  2  2  3  3  3  3  3  2  2  3  3  3|             
      Nephropathy                          | 1  1  2  2  2  1  2  1  1  1     2     1  1  2  1  2  1  2  1  1  1  2  2|             
      Interstitial Tissue, Pigmentation    |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                           2                 2            |             
      Renal Tubule, Pigmentation           |          2        4     3                 2  3              2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|             
                                           | 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X  X     X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Subacute               |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1              2               |             
      Basophilic Focus                     |       X  X  X  X  X        X  X  X     X  X  X  X  X     X  X  X     X  X|             
      Clear Cell Focus                     |                      X     X                    X        X  X        X  X|             
      Granuloma                            |       2     1        3                 1     2                       1   |             
      Hematopoietic Cell Proliferation     |                1                                                         |             
      Hepatodiaphragmatic Nodule           |    X                          X              X        X  X           X   |             
      Hyperplasia, Focal                   |          2              3                       3  2                 3  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               | 1     1              2                    1  2                    2      |             
      Mixed Cell Focus                     | X        X  X              X                                   X         |             
      Bile Duct, Cyst                      |                                  X                                       |             
      Bile Duct, Hyperplasia               | 1  2     1     1                                                  2      |             
      Centrilobular, Atrophy               |    3                    2           2                                    |             
      Hepatocyte, Vacuolization Cytoplasmic| 2                       3           3                 4                  |             
      Kupffer Cell, Pigmentation           |                                           1                              |             
      Lobules, Necrosis                    |                                     2     1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +           +                 +           +               |             
      Accessory Spleen                     |                                              X                           |             
      Fat, Necrosis                        |          3     1           3                             2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1           2  2     2                 1     2  2  1   |             
      Acinar Cell, Cytoplasmic Alteration  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2  3                                                |             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|             
                                           | 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                | 2                                3  3                                    |             
      Mucosa, Hyperplasia                  |                      3  2        2  3                 1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                         X|             
      Edema                                |                      2                                            2      |             
      Erosion                              |                                                                          |             
      Ulcer                                |                         2           2                                    |             
      Epithelium, Dilatation               |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3              2  1        2     1     1     1     1     1     1        2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | X  X     X     X              X                 X                       X|             
      Angiectasis                          |       2  2        2                                            2         |             
      Atrophy                              |                                                                   4      |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hyperplasia, Focal                   |       1              2                       2                           |             
      Hypertrophy, Focal                   |                                                                2         |             
      Metaplasia, Osseous                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    3                                                              3      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                       3                  |             
      Vacuolization Cytoplasmic, Focal     | 1              2     2  1        1     2        1        1           3   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |    3                                                              4      |             
      Pars Distalis, Angiectasis           |       2     2                                                            |             
      Pars Distalis, Atrophy               |                                                                   4      |             
      Pars Distalis, Cyst                  |    X        X                 X                    X  X     X            |             
      Pars Distalis, Hyperplasia           |                1                          1  2     2                    2|             
      Pars Intermedia, Angiectasis         |                2                                                     2   |             
      Pars Intermedia, Cyst                |                                              X     X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|             
                                           | 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |                3     2     2     1           1  1  2                    1|             
      Follicle, Cyst                       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                2                                            1            |             
      Inflammation, Chronic                |                                        2        2           1            |             
      Inflammation, Suppurative            |                                     2  2                                 |             
      Necrosis                             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X  X                 X                    X     X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                   2  2                                                   |             
      Hyperplasia, Cystic                  |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                          M                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    3  2                             2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                    +           +                          +  +      |             
      Mediastinal, Hemorrhage              |                                     2                                    |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                   3      |             
      Mediastinal, Pigmentation            |                                                                3  3      |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                   2      |             
      Pancreatic, Pigmentation             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
      Hemorrhage                           |                                     1                                    |             
      Hyperplasia, Histiocytic             |                                                                   3      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2     2              2                                                   |             
      Pigmentation                         |                                     2                 3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                      1   |             
      Hyperplasia, Histiocytic             |                                                                   2      |             
      Hyperplasia, Lymphoid                |                                                    2              2      |             
      Hyperplasia, Plasma Cell             |                                                                         2|             
      Inflammation, Suppurative            |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|             
                                           | 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |    3                                                                     |             
      Hematopoietic Cell Proliferation     |    2        2  2                    3     2     2  2     2     1        2|             
      Infiltration Cellular, Histiocyte    |                      2                                                   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 3     2  3  2  2  2  2     2  2  2     3     2  2  3  3  2  2  3  3  2  3|             
      Lymphoid Follicle, Atrophy           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  1     2  1  2     2  3  2  1  3  2  2  2  2     2  3  1           2  1|             
      Hyperplasia, Lobular                 |                3                          2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1                                   3      |             
      Exudate                              |                                                                   X      |             
      Inflammation, Subacute               |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteopetrosis             | 2           3           3        2                       3     3         |             
      Femur, Osteopetrosis                 |             4           3              3                 3     3         |             
      Sternum, Osteopetrosis               |             4           3                          2     3     3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X              X     X           X     X        X        X           X  X|             
      Developmental Malformation           |                                                                          |             
      Hydrocephalus                        | 2                                2                                      2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                       1                  |             
      Hemorrhage                           |                                     1                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |          1  1  1     1  1           2  2        2  1     1           1  1|             
      Inflammation, Subacute               |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|             
                                           | 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                       3                  |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1                          2        2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                         X                             X                  |             
      Foreign Body                         |                                                       2              1   |             
      Fungus                               |                         X                                                |             
      Glands, Hyperplasia                  |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                         1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                       +                                    |             
      Cataract                             |             3                       3                                    |             
      Retina, Atrophy                      |             3                       4                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                         1|             
      Mineralization                       | 2  3  3  3  3  3  3  2  2  3  2  2  2  2  2  2  1  3  2  3  3  3  3  3  2|             
      Nephropathy                          | 2  1  1  1  2  2  3  2  2  2  2  3  1  1  1  1  2  1  1  3  1  1  1  2  2|             
      Interstitial Tissue, Pigmentation    |                                                                   2      |             
      Renal Tubule, Cytoplasmic Alteration |                                        3                                 |             
      Renal Tubule, Pigmentation           |    4                                2                             2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                                                |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2|                                            |            |
                                           | 9| 9| 9| 7| 9| 6| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    | X              X                                                         |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |     11     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 1  1                                                                     |      6  1.7|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     45     |
      Clear Cell Focus                     | X                                                                        |     10     |
      Granuloma                            |    1                                                                     |     13  1.6|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |          X                                                               |     14     |
      Hyperplasia, Focal                   |                                                                          |      9  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.3|
      Inflammation, Subacute               |          1                                                               |     10  1.3|
      Mixed Cell Focus                     |                         X                                                |      7     |
      Bile Duct, Cyst                      |                                                                          |      3     |
      Bile Duct, Hyperplasia               |       1  1     1                                                         |     14  1.4|
      Centrilobular, Atrophy               |                2     2                                                   |      7  2.1|
      Hepatocyte, Vacuolization Cytoplasmic| 2                 4                                                      |     10  2.9|
      Kupffer Cell, Pigmentation           | 1              3                                                         |      3  1.7|
      Lobules, Necrosis                    |                1                                                         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +                                                      |   9        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                   2                                                      |      7  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                            1                                             |     17  1.5|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                            1                                             |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2|                                            |            |
                                           | 9| 9| 9| 7| 9| 6| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      4  2.3|
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  2.8|
      Mucosa, Hyperplasia                  |                                                                          |      8  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Edema                                |                                                                          |      2  2.0|
      Erosion                              |                   1                                                      |      5  1.4|
      Ulcer                                |                                                                          |      2  2.0|
      Epithelium, Dilatation               |          2                                                               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    1                                                                     |     18  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |             X                                                            |     11     |
      Angiectasis                          |          2                                                               |      7  2.0|
      Atrophy                              |                                                                          |      2  3.5|
      Basophilic Focus                     |                                                                          |      1     |
      Congestion                           |                   2                                                      |      1  2.0|
      Hematopoietic Cell Proliferation     |                      1  1                                                |      4  1.3|
      Hyperplasia, Focal                   |          1                                                               |      6  1.3|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |    2                    3                                                |     14  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                      1                                                   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2|                                            |            |
                                           | 9| 9| 9| 7| 9| 6| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pigmentation                         |                                                                          |      2  3.5|
      Pars Distalis, Angiectasis           |                2  4  2                                                   |     11  2.5|
      Pars Distalis, Atrophy               |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  | X              X  X  X                                                   |     23     |
      Pars Distalis, Hyperplasia           | 1           1              1                                             |     16  1.7|
      Pars Intermedia, Angiectasis         |                            2                                             |      4  2.0|
      Pars Intermedia, Cyst                |    X                    X  X                                             |      5     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 3  1        1           1                                                |     21  1.4|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      1  4.0|
      Hyperplasia                          | 2                    2                                                   |      4  1.8|
      Inflammation, Chronic                | 2                                                                        |      8  1.8|
      Inflammation, Suppurative            |                      2                                                   |      4  2.3|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                         X                                                |     12     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                      2                                                   |      4  2.0|
      Hyperplasia, Cystic                  |                   2                                                      |      2  1.5|
      Pigmentation                         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                   M                                                      |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myelofibrosis                        |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +                                                   |  14        |
      Mediastinal, Hemorrhage              |                                                                          |      2  1.5|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      2  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2|                                            |            |
                                           | 9| 9| 9| 7| 9| 6| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                      2     2                                             |      4  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |                            2                                             |      7  2.0|
      Pigmentation                         |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                      2                                                   |      1  2.0|
      Hemorrhage                           |                                                                          |      3  2.3|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                         2                                                |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           | X                                                                        |      1     |
      Fibrosis                             |                      2                                                   |      4  2.5|
      Hematopoietic Cell Proliferation     | 2                       2                                                |     19  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Necrosis                             |                      4                                                   |      2  3.5|
      Pigmentation                         | 2     3  3     2        2  2                                             |     44  2.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 1  1  2           2  2  2                                                |     41  1.8|
      Hyperplasia, Lobular                 |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      3  2.0|
      Exudate                              |                                                                          |      2     |
      Inflammation, Subacute               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2|                                            |            |
                                           | 9| 9| 9| 7| 9| 6| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Calvarium, Osteopetrosis             |    2           2        2  2                                             |     20  2.4|
      Femur, Osteopetrosis                 |                4           2                                             |     12  2.8|
      Sternum, Osteopetrosis               |                4           2                                             |     12  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |    X                    X                                                |     16     |
      Developmental Malformation           |       X                                                                  |      1     |
      Hydrocephalus                        |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |             1  1        1  1                                             |     24  1.2|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      7     |
      Foreign Body                         |                                                                          |      3  1.7|
      Fungus                               |                                                                          |      4     |
      Glands, Hyperplasia                  | 2                                                                        |      1  2.0|
      Mucosa, Hyperplasia                  | 2                                                                        |      7  2.1|
      Mucosa, Metaplasia, Squamous         |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.0|
      Retina, Atrophy                      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2|                                            |            |
                                           | 9| 9| 9| 7| 9| 6| 4| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 1                                                                        |      2  1.0|
      Mineralization                       | 2  3  3  3  2  2  2  3  3  3                                             |     59  2.6|
      Nephropathy                          | 3  3  1  1  1  1  1  1  2  2                                             |     58  1.6|
      Interstitial Tissue, Pigmentation    |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration |    3                    3                                                |      5  2.6|
      Renal Tubule, Pigmentation           |                      2                                                   |     10  2.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|             
                                           | 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         2|             
      Parasite Metazoan                    |                   X           X                 X                    X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                         3|             
      Edema                                |                                                                         3|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                          3                                       |             
      Basophilic Focus                     |    X  X     X  X     X     X              X  X  X  X     X        X  X   |             
      Clear Cell Focus                     |                                           X                              |             
      Congestion                           |                                                                          |             
      Granuloma                            |                      1        1                 1                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                    X  X     X  X              X                    X|             
      Hyperplasia, Focal                   |          3                       3                       3           3  3|             
      Hyperplasia, Lymphoid                |                      1                                                   |             
      Inflammation, Subacute               |    1              2        1  1           2     1     1           1      |             
      Mixed Cell Focus                     |    X        X                                            X               |             
      Bile Duct, Cyst                      |                      X                                                   |             
      Bile Duct, Hyperplasia               | 1  1     1  1           2     1     1     1  1        1  2               |             
      Centrilobular, Atrophy               |                         2              2     2           2              4|             
      Centrilobular, Necrosis              |                                     2                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|             2  2           1     2     2     2                          3|             
      Kupffer Cell, Pigmentation           |                         2                    1        1                  |             
      Lobules, Necrosis                    |                            1           1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                             +                                   +|             
      Fat, Necrosis                        |       3                             4                                   4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1        1  1        1     1  1  3  1  1                 2     2  1     1|             
      Cyst                                 |                                              X                           |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
      Acinar Cell, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |          3                                                           2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       4                                                                 3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|             
                                           | 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                         1|             
      Ulcer                                |       3                                                                  |             
      Mucosa, Hyperplasia                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                          2               |             
      Erosion                              |                                     2                                   2|             
      Ulcer                                |                                                                          |             
      Epithelium, Dilatation               |                                                 2                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1        1           2        1                                1   |             
      Thrombosis                           |                                                                         X|             
      Myocardium, Inflammation, Chronic    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X     X              X                             X           X      |             
      Angiectasis                          |                      2                          2  2                     |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |             1                                                            |             
      Hemorrhage                           | 2                                                                        |             
      Hyperplasia, Focal                   | 1     2                       1              1  1        1  2            |             
      Hypertrophy, Focal                   |                                           2                              |             
      Pigmentation                         |                                                          3               |             
      Vacuolization Cytoplasmic, Diffuse   |                                     2                                   2|             
      Vacuolization Cytoplasmic, Focal     |    2  1        3                             1        1                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1  2              2  1                             3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                          3               |             
      Pars Distalis, Angiectasis           |                      2     3     2              3  2  2           3      |             
      Pars Distalis, Cyst                  |             X     X     X     X                    X  X           X     X|             
      Pars Distalis, Hyperplasia           |                               2                 2     2                  |             
      Pars Intermedia, Angiectasis         |                      2                                                   |             
      Pars Intermedia, Cyst                |             X           X     X           X                             X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|             
                                           | 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |       1     1  1           1                 1     1  2  1               |             
      Follicle, Cyst                       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              2                           |             
      Hyperplasia                          |             2                                2  2                        |             
      Inflammation, Chronic                |                               2                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X        X           X              X  X                          X|             
      Mineralization                       |                                           1                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                   2                                                      |             
      Hyperplasia, Cystic                  |          1                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +  +  M                           |             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
      Myelofibrosis                        |                   3           1     3                             1     4|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +           +  +     +           +              +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                              3                           |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              2           3               |             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Plasma Cell             |                                        3     2                           |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hemorrhage                           |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|             
                                           | 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                            X                                             |             
      Fibrosis                             |                         4              2              1                 3|             
      Hematopoietic Cell Proliferation     | 2        2              2  2     3        2        1     2              2|             
      Pigmentation                         | 2  2  2  2        2  2     2  2           2     2  2  2     2  2  2  2   |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                                                                        |             
      Cyst                                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  4     1     2  1  2     2  1  3     1  1  2     1  3  2     1  3|             
      Hyperplasia, Lobular                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrous Osteodystrophy               |          1                                                               |             
      Calvarium, Osteopetrosis             |                      1     2                       2        2            |             
      Femur, Osteopetrosis                 | 3                                   2              2        3            |             
      Sternum, Osteopetrosis               | 3                    1                             2        3            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        X  X        X     X               |             
      Developmental Malformation           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                           3            |             
      Edema                                |          2                                                           2   |             
      Hemorrhage                           |                                                          1               |             
      Infiltration Cellular, Histiocyte    |          1     1        3  1        2     2  3  1        2  3  1     1   |             
      Inflammation, Subacute               |                1                          2                              |             
      Alveolar Epithelium, Hyperplasia     |                      1                    3                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          X  X  X              X                                         X|             
      Foreign Body                         |                               2                                          |             
      Fungus                               |                                                                          |             
      Glands, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|             
                                           | 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                         2|             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Cataract                             |                3                                                         |             
      Retina, Atrophy                      |                4                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                       2                                            1|             
      Mineralization                       | 2  3  3  3  2  3  3  2  3  3  3  3  2  3  3  3  3  3  3  2  3  3  3  2  3|             
      Nephropathy                          | 1  2  3  4  1  3  1  2  1  3  2  1  1  2  2  2  2  2  2  2  2  2  1  2  2|             
      Interstitial Tissue, Pigmentation    |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                        2                                 |             
      Renal Tubule, Pigmentation           |                         3           2  4     2           3              3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|             
                             DAY ON TEST   | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|             
                                           | 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                       X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |             X  X        X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                      3                           |             
      Basophilic Focus                     |             X  X  X  X  X  X  X  X  X  X  X     X  X     X  X     X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                             3            |             
      Granuloma                            |                         2                    2  1  1  1  2               |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hepatodiaphragmatic Nodule           |       X        X              X                                          |             
      Hyperplasia, Focal                   |                         3                 3     3                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                   1        1           1              1  1              1|             
      Mixed Cell Focus                     |                   X        X  X     X                             X      |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |       2  1     3     2     1        1                          2  1     1|             
      Centrilobular, Atrophy               |       2        2                                            2  2         |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|       3     2                                2                 3  3      |             
      Kupffer Cell, Pigmentation           | 3        1     2     2                                            1      |             
      Lobules, Necrosis                    |                   1                                            2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Fat, Necrosis                        |    4                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2     1  2                 1  1  1  1  2  1  1        2  3      |             
      Cyst                                 |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |             3                                                            |             
      Acinar Cell, Hyperplasia, Focal      |                            2                    2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1                 1                                                |             
      Acinar Cell, Cytoplasmic Alteration  |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|             
                             DAY ON TEST   | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|             
                                           | 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |       3                                                                  |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2                                                                  |             
      Erosion                              |       2                                                           2      |             
      Ulcer                                |             2                                                            |             
      Epithelium, Dilatation               |                         2                             2                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             2     1        1  1              2  1                        |             
      Thrombosis                           |                                                                          |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X     X                 X  X                           |             
      Angiectasis                          |                         2                                                |             
      Congestion                           |       2  2                                                               |             
      Cyst                                 |                                                    X                     |             
      Hematopoietic Cell Proliferation     |          1                                                     1         |             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia, Focal                   |                         1           2                    1               |             
      Hypertrophy, Focal                   |                                        2                                 |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       2                    2           2        1                 1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2     1           1                    1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |       3                                                                  |             
      Pars Distalis, Angiectasis           |                2                                            1  3         |             
      Pars Distalis, Cyst                  |    X  X        X     X  X                 X  X        X  X     X         |             
      Pars Distalis, Hyperplasia           |          1     1     2  1                 3  2  2        2               |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|             
                             DAY ON TEST   | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|             
                                           | 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |             2     1           1  1        1              1               |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          2               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Inflammation, Suppurative            |                                                          2           2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                             X     X     X                           |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             3                                                            |             
      Hydrometra                           |                                                    3        2            |             
      Hyperplasia, Cystic                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +     M      |             
      Exudate                              |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                  3                 2                     |             
      Myelofibrosis                        |       3              2  1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +     +                                      +  +  +      |             
      Mediastinal, Hemorrhage              |             2                                                            |             
      Mediastinal, Pigmentation            |             3                                               3            |             
      Pancreatic, Hemorrhage               |       2                                                                  |             
      Renal, Hemorrhage                    |       3                                                                  |             
      Renal, Pigmentation                  |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2     2                                2                        |             
      Hemorrhage                           |                                                             4            |             
      Hyperplasia, Lymphoid                |                   2                                2                     |             
      Hyperplasia, Plasma Cell             |             2                    3                       2               |             
      Infiltration Cellular, Mast Cell     |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3                                                     3            |             
      Hyperplasia, Lymphoid                |                                  2                 2     2               |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|             
                             DAY ON TEST   | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|             
                                           | 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                                                   3      |             
      Hematopoietic Cell Proliferation     |          3                    1  2           1  2  3           3         |             
      Pigmentation                         |    3     2  2     2  2  2  3  2     3  3  2  2  2     2  2  3        3  3|             
      Lymphoid Follicle, Atrophy           |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       1  2  3     2  2     2  1     2  2  2  2  2  1     2     2  2  1  1|             
      Hyperplasia, Lobular                 |                   1        2           3  2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                       X                  |             
      Fibrous Osteodystrophy               |                                                                          |             
      Calvarium, Osteopetrosis             |                            2                                   2  3      |             
      Femur, Osteopetrosis                 |                                                                   3      |             
      Sternum, Osteopetrosis               |                            2                                      3      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X     X        X           X                          X     X|             
      Developmental Malformation           |                                                       X                  |             
      Hydrocephalus                        |    3        2                          2                          2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2           2|             
      Edema                                |                               2                                          |             
      Hemorrhage                           |                                                                2         |             
      Infiltration Cellular, Histiocyte    |          1     1        1     1  2                          3            |             
      Inflammation, Subacute               |                                     1                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          X                             X  X     X        X               |             
      Foreign Body                         |          2                                      2                        |             
      Fungus                               |          X                                      X                        |             
      Glands, Hyperplasia                  |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|             
                             DAY ON TEST   | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|             
                                           | 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.25%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia                  |          2     2                                2                        |             
      Mucosa, Metaplasia, Squamous         |          2        1                             1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |          +        +                       +                              |             
      Cataract                             |          3                                3                              |             
      Retina, Atrophy                      |          3                                4                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 3  3  2  2  2  3  3  2  3  3  3  3  2  2  3  3  3  2  3  2  3  3  2  3  3|             
      Nephropathy                          |       2  1  3  1  2  1  2  2  3  1  2  2  2  2  2  1  1  2     1  3  1  1|             
      Interstitial Tissue, Pigmentation    |                                                                   3      |             
      Renal Tubule, Cytoplasmic Alteration |                3                 3                             2         |             
      Renal Tubule, Pigmentation           |       3  2     3                                               3  3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 4| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5|                                            |            |
                                           | 7| 0| 1| 3| 1| 1| 0| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                            X                                             |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  3.0|
      Parasite Metazoan                    | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |             1                                                            |      5  2.4|
      Basophilic Focus                     | X  X  X  X  X  X     X  X                                                |     39     |
      Clear Cell Focus                     |    X  X  X  X                                                            |      5     |
      Congestion                           |                                                                          |      1  3.0|
      Granuloma                            |    3     2     1     1                                                   |     13  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |    X  X  X  X           X  X                                             |     16     |
      Hyperplasia, Focal                   |       3        3        2                                                |     11  2.9|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Subacute               |    2                    1                                                |     16  1.2|
      Mixed Cell Focus                     |                X                                                         |      9     |
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 1              1                                                         |     22  1.3|
      Centrilobular, Atrophy               |                                                                          |      9  2.2|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                   2                                                      |     13  2.2|
      Kupffer Cell, Pigmentation           |                   3                                                      |      9  1.8|
      Lobules, Necrosis                    |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                 +                                                |   6        |
      Fat, Necrosis                        |       3                 3                                                |      6  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |       2  2        3     2                                                |     29  1.5|
      Cyst                                 |                                                                          |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      1  3.0|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 4| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5|                                            |            |
                                           | 7| 0| 1| 3| 1| 1| 0| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.0|
      Acinar Cell, Cytoplasmic Alteration  |                         3                                                |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |          3     1                                                         |      5  2.6|
      Erosion                              |                2                                                         |      3  2.0|
      Ulcer                                |    3     3                                                               |      3  3.0|
      Mucosa, Hyperplasia                  |                1                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |          2                                                               |      3  2.0|
      Erosion                              |                                                                          |      4  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Dilatation               |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |          2  1  2                                                         |     15  1.3|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Inflammation, Chronic    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |             X  X                                                         |     11     |
      Angiectasis                          |                                                                          |      4  2.0|
      Congestion                           |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |    1           2     2     2                                             |     14  1.4|
      Hypertrophy, Focal                   |                                                                          |      2  2.0|
      Pigmentation                         |                   2                                                      |      2  2.5|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |          1           2                                                   |     12  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |    1                                                                     |     10  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 4| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5|                                            |            |
                                           | 7| 0| 1| 3| 1| 1| 0| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pigmentation                         |                                                                          |      2  3.0|
      Pars Distalis, Angiectasis           |                                                                          |     10  2.3|
      Pars Distalis, Cyst                  |             X                                                            |     19     |
      Pars Distalis, Hyperplasia           |                                                                          |     11  1.8|
      Pars Intermedia, Angiectasis         |       2                                                                  |      2  2.0|
      Pars Intermedia, Cyst                |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |       X                                                                  |      3     |
      C-Cell, Hyperplasia                  |       1  1              1                                                |     17  1.1|
      Follicle, Cyst                       |                X                                                         |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  2.0|
      Hyperplasia                          |                         2                                                |      4  2.0|
      Inflammation, Chronic                |                            2                                             |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | X              X  X        X                                             |     14     |
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrometra                           |                                                                          |      3  2.3|
      Hyperplasia, Cystic                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Exudate                              |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     |                                                                          |      2  2.5|
      Myelofibrosis                        |       2           4     1                                                |     11  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |  15        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 4| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5|                                            |            |
                                           | 7| 0| 1| 3| 1| 1| 0| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      5  2.2|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |    4  2                 2                                                |      8  2.5|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      3  3.0|
      Hyperplasia, Lymphoid                |          2     2                                                         |      5  2.0|
      Hyperplasia, Plasma Cell             |       2                                                                  |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                          |      5  2.6|
      Hematopoietic Cell Proliferation     |    2           2        2                                                |     19  2.1|
      Pigmentation                         | 2  2  2  2     2     2  2  2                                             |     42  2.2|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Cystic                  | 2  1  2  2  1  2  3  1  2  1                                             |     47  1.8|
      Hyperplasia, Lobular                 |          2     4                                                         |      7  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|
      Calvarium, Osteopetrosis             |    3                    3                                                |      9  2.2|
      Femur, Osteopetrosis                 |    3                    3                                                |      7  2.7|
      Sternum, Osteopetrosis               |    3                    3                                                |      8  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 4| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5|                                            |            |
                                           | 7| 0| 1| 3| 1| 1| 0| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |          X     X        X                                                |     13     |
      Developmental Malformation           |                                                                          |      1     |
      Hydrocephalus                        |          2     2                                                         |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      4  2.3|
      Edema                                |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Infiltration Cellular, Histiocyte    |       1                                                                  |     19  1.6|
      Inflammation, Subacute               |                                                                          |      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                X                                                         |     11     |
      Foreign Body                         |                                                                          |      3  2.0|
      Fungus                               |                                                                          |      2     |
      Glands, Hyperplasia                  |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      4  2.0|
      Mucosa, Metaplasia, Squamous         |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   5        |
      Cataract                             |             2                                                            |      4  2.8|
      Retina, Atrophy                      |             3                                                            |      4  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      3  1.3|
      Mineralization                       | 3  3  3  3  2  2  2  2  2  3                                             |     60  2.7|
      Nephropathy                          | 1  2  2  2  2  2  1  1  2  1                                             |     57  1.8|
      Interstitial Tissue, Pigmentation    |                                                                          |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      4  2.5|
      Renal Tubule, Pigmentation           |                   4                                                      |     12  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 7| 7| 7| 4| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5|                                            |            |
                                           | 7| 0| 1| 3| 1| 1| 0| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Hyperplasia                  |       1                                                                  |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|             
                             DAY ON TEST   | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|             
                                           | 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.50%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                       X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                         X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                   3      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    2                          2        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                    2     3                                    |             
      Basophilic Focus                     | X     X  X     X     X     X  X     X                    X  X        X  X|             
      Clear Cell Focus                     |                               X                                         X|             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |          1     1              2              1                           |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Hepatodiaphragmatic Nodule           |          X     X           X        X        X  X     X        X         |             
      Hyperplasia, Focal                   |          3                 3        2              1        2           3|             
      Inflammation, Subacute               |                      1                                      1        1   |             
      Mixed Cell Focus                     |                X                                                         |             
      Bile Duct, Hyperplasia               | 1     1     2        1           1                                1      |             
      Centrilobular, Atrophy               |       2     3                                                            |             
      Centrilobular, Necrosis              |                   2                                      3               |             
      Hepatocyte, Vacuolization Cytoplasmic|    2        3           4              4        2                 2      |             
      Kupffer Cell, Hyperplasia            |                                                          2               |             
      Kupffer Cell, Pigmentation           |                                                 2        3               |             
      Lobules, Necrosis                    |                                                                   3     1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +  +                 +                    +                     |             
      Fat, Necrosis                        | 2        3  3                 3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  1  2              1     1     2        1           2            |             
      Hyperplasia, Lymphoid                |                                                    1                     |             
      Acinar Cell, Cytoplasmic Alteration  |    4                                   2        3  3                     |             
      Acinar Cell, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Inflammation, Suppurative            |                                                 2                        |             
      Acinar Cell, Cytoplasmic Alteration  |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|             
                             DAY ON TEST   | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|             
                                           | 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.50%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              2                           |             
      Erosion                              |                                           1                              |             
      Fibrosis                             |                               3        4                                 |             
      Perforation                          |                               X                                          |             
      Ulcer                                |    4  3                 4              4     2  4                        |             
      Mucosa, Hyperplasia                  |    4  2                 2     3        4     2  3                 2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                         2                                                |             
      Ulcer                                |    2                    2                                                |             
      Epithelium, Dilatation               |                                                                      2   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1        2           2  1  1        2           1              1|             
      Thrombosis                           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X           X  X                              |             
      Angiectasis                          |                      3           2                                   2  2|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        2                 1               |             
      Hyperplasia, Focal                   |                                                             1        2  3|             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis                             |                         2                                                |             
      Pigmentation                         |             3                                                            |             
      Vacuolization Cytoplasmic, Diffuse   |                         3              2                                 |             
      Vacuolization Cytoplasmic, Focal     |          1  2                                   2           1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Hyperplasia                          |    1  1  1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|             
                             DAY ON TEST   | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|             
                                           | 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.50%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |    3                                   2                                 |             
      Pars Distalis, Angiectasis           |             3           3           3  3                                 |             
      Pars Distalis, Cyst                  |                      X              X  X              X     X     X     X|             
      Pars Distalis, Hyperplasia           |                      2  3  1        3  3     1        1     2     2      |             
      Pars Intermedia, Angiectasis         |          3                                                               |             
      Pars Intermedia, Cyst                |                                        X                                 |             
      Pars Intermedia, Hyperplasia         |          2                                                               |             
      Pars Intermedia, Hypertrophy, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2                                                                     |             
      Ultimobranchial Cyst                 |                                                    X                     |             
      C-Cell, Hyperplasia                  | 1           1                          1        1           1           2|             
      Follicle, Cyst                       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |          1                                                               |             
      Inflammation, Chronic                |          1                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X     X        X        X  X  X                       X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                            2                                             |             
      Hyperplasia, Cystic                  | 1                                   1                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |                                                                          |             
      Prolapse                             |                                                                X         |             
      Endometrium, Fibrosis                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                    +  M                             M        +      |             
      Exudate                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hypercellularity                     |                                                    3     2               |             
      Myelofibrosis                        |                                  1                          2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +  +     +     +  +                 +           +   |             
      Mediastinal, Hemorrhage              |                               2     2                    2               |             
      Mediastinal, Pigmentation            |                               2     2                    3               |             
      Pancreatic, Hemorrhage               |                      1                                               2   |             
      Pancreatic, Pigmentation             |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|             
                             DAY ON TEST   | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|             
                                           | 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.50%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2                                3  2                 2           1|             
      Hemorrhage                           |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                               2           2           2     2     2      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2                                   1  2        4                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                        2                                 |             
      Infiltration Cellular, Mast Cell     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |             3                          1                                 |             
      Hematopoietic Cell Proliferation     |          2                    2        3        2  4     3  1     2      |             
      Pigmentation                         | 2  3     2     3  3  3     2  2  2        2  2  3     2  3  2     2  3  2|             
      Lymphoid Follicle, Atrophy           |                                                                   3      |             
      Red Pulp, Atrophy                    |                               1                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  1  2  2  2  2  2  1  3     2  2  1  2     1  3  3     2  2     1     1|             
      Hyperplasia, Lobular                 |                   2        1                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2                                            1                        |             
      Calvarium, Osteopetrosis             |          3              2  2  2           2  2  2           1            |             
      Femur, Osteopetrosis                 |          3                 2                    2                        |             
      Sternum, Osteopetrosis               |          4                 2                    2                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X        X        X           X                                          |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
      Hemorrhage                           |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|             
                             DAY ON TEST   | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|             
                                           | 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.50%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1     1        1        1  1  3     1     1           1  1            |             
      Inflammation, Subacute               |                                  2                                       |             
      Leukocytosis                         |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |          1                    3                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |    X           X              X           X              X  X     X     X|             
      Foreign Body                         |                2              3                             1           2|             
      Fungus                               |                                                          X  X     X      |             
      Mucosa, Hyperplasia                  |                2              3                             2     3      |             
      Mucosa, Metaplasia, Squamous         |                                                          1  2            |             
      Mucosa, Necrosis                     |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                         +                    +|             
      Cataract                             |          3                                         3                    4|             
      Retina, Atrophy                      |          4                                         3                    4|             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Ectopic Harderian                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |    1                                         1  1                        |             
      Mineralization                       | 3  2  3  3  2  2  3  3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Nephropathy                          | 3  4  2  2  2  3  3  2  2  1  3  2  1  2  1  2  4  2  1  1  3  1  1  2  2|             
      Renal Tubule, Cytoplasmic Alteration |             2                                                            |             
      Renal Tubule, Pigmentation           |       2     3           2                                                |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        2           4                     |             
      Hemorrhage                           |                                        1           3                     |             
      Mucosa, Hyperplasia                  |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|             
                             DAY ON TEST   | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|             
                                           | 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.50%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                   4      |             
      Mucosa, Hyperplasia                  |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                           1   |             
      Basophilic Focus                     | X     X  X     X  X  X  X  X  X  X     X           X  X  X        X  X  X|             
      Clear Cell Focus                     |                      X     X                                             |             
      Eosinophilic Focus                   |                                                       X                  |             
      Granuloma                            |    1     2        1     1        1  2  1                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X     X  X  X        X     X                 X     X  X               |             
      Hyperplasia, Focal                   | 3           2  1        3     2  1                 2                     |             
      Inflammation, Subacute               |                            1                                             |             
      Mixed Cell Focus                     |                   X  X     X     X                 X                     |             
      Bile Duct, Hyperplasia               |       1        1        1        1                 1              1     3|             
      Centrilobular, Atrophy               |                                           3                    2        2|             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|    2                                      3                    4        2|             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                     1     3                    3         |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                          +              +   |             
      Fat, Necrosis                        |                                                       3              3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  1     3           1              1     1        1           2     1  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  | 3              3                                               2         |             
      Acinar Cell, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  | 3                                                  3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|             
                             DAY ON TEST   | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|             
                                           | 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.50%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3  3           2  3                                            2  4      |             
      Erosion                              |                                                                          |             
      Fibrosis                             | 3  2                                                                     |             
      Perforation                          |                                                                   X      |             
      Ulcer                                | 4                 3                                                      |             
      Mucosa, Hyperplasia                  | 4  1           3  2                                            2  3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2              1           2                                             |             
      Erosion                              |                                                                         1|             
      Ulcer                                |                                                                2         |             
      Epithelium, Dilatation               |                                                                         2|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                           |             
      Fibrosis                             |                                              3                           |             
      Inflammation, Chronic Active         |                                              3                           |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     2     1     1  1  2  1                    1  1                  |             
      Thrombosis                           |                                           X                    X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X     X  X                                    |             
      Angiectasis                          |       2              2  2                                                |             
      Congestion                           |                                                                2         |             
      Hematopoietic Cell Proliferation     |                      1                                         2         |             
      Hyperplasia, Focal                   |                      2                                                   |             
      Hypertrophy, Focal                   |                                                                         2|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 1                 3  2     1           2              2           2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Hyperplasia                          |          2           2                             3                 1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|             
                             DAY ON TEST   | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|             
                                           | 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.50%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                        2                                 |             
      Pars Distalis, Angiectasis           |                         2                             3        2        3|             
      Pars Distalis, Cyst                  | X     X     X  X        X              X  X     X     X  X     X     X  X|             
      Pars Distalis, Hyperplasia           | 2     1        1                       2  1     1     2  2           2   |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Intermedia, Hypertrophy, Focal  |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    1                 1     1        2                                    |             
      Follicle, Cyst                       |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                         1                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                  X  X        X     X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                      2   |             
      Hyperplasia, Cystic                  |                      1                                               1   |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |                               2                                          |             
      Prolapse                             |                                                                          |             
      Endometrium, Fibrosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                M           +              +                             +|             
      Exudate                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Hypercellularity                     |                            4                                             |             
      Myelofibrosis                        |                         1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +                          +                        |             
      Mediastinal, Hemorrhage              |                      1                          3                        |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |       1                                                                  |             
      Pancreatic, Pigmentation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|             
                             DAY ON TEST   | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|             
                                           | 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.50%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |          2                                      2                        |             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Hyperplasia, Plasma Cell             |                2  2                       3                              |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1        1                                                     2         |             
      Hyperplasia, Lymphoid                |             2                                   2                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2        1           1        1              1                       2   |             
      Pigmentation                         | 2  2  2  2  3     2     3  2  2  2  2  2     3  3           3     2     2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 3           3            |             
      Hemorrhage                           |                                                 2           2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  2  2  1     2  3  1     2  1     1     3  2     1           1  2     2|             
      Hyperplasia, Lobular                 |                               3     2                          2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2              1                                                         |             
      Calvarium, Osteopetrosis             | 3                                                     2                  |             
      Femur, Osteopetrosis                 |                                           2                              |             
      Sternum, Osteopetrosis               |                                           2                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X              X                          X                 X  X      |             
      Hydrocephalus                        |    3                                                                     |             
      Mineralization                       |                               1                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|             
                             DAY ON TEST   | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|             
                                           | 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.50%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                2  3           2            |             
      Hemorrhage                           |             1                                                            |             
      Infiltration Cellular, Histiocyte    | 1  1              1  1                 1                 3           3   |             
      Inflammation, Subacute               |                                                                      2   |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                X     X     X                    X                        |             
      Foreign Body                         |                            3                                             |             
      Fungus                               |                                                 X                        |             
      Mucosa, Hyperplasia                  |                      2     3                    3                        |             
      Mucosa, Metaplasia, Squamous         |                      1                                                   |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +                                             |             
      Cataract                             |          3                 3                                             |             
      Retina, Atrophy                      |          4                 3                                             |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Ectopic Harderian                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                                            |             
      Inflammation, Suppurative            | 1              1  1  1        1        1                          1      |             
      Mineralization                       | 2  3  3  2  3  2  3  3  3  3  2  3  3  2  3  3  3  1  3  3  3  3  3  3  3|             
      Nephropathy                          | 4  3  3  1  1  4  3  3  2  2  3  2  2  1  1  2     3  3  2     1  3  3  2|             
      Renal Tubule, Cytoplasmic Alteration |    1                          1                                          |             
      Renal Tubule, Pigmentation           |                                           2                    2        4|             
      Transitional Epithelium, Hyperplasia |                1     1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3|                                            |            |
                                           | 7| 1| 1| 5| 7| 0| 0| 0| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.50%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  4.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  I  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  3.0|
      Parasite Metazoan                    |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |       3                                                                  |      6  2.2|
      Basophilic Focus                     | X     X  X     X  X  X     X                                             |     36     |
      Clear Cell Focus                     |                                                                          |      4     |
      Eosinophilic Focus                   |                X                                                         |      2     |
      Granuloma                            | 1                 1                                                      |     13  1.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |       X        X                                                         |     19     |
      Hyperplasia, Focal                   |    3                                                                     |     14  2.2|
      Inflammation, Subacute               |                                                                          |      4  1.0|
      Mixed Cell Focus                     |                                                                          |      6     |
      Bile Duct, Hyperplasia               | 1     1        2                                                         |     16  1.3|
      Centrilobular, Atrophy               |          2     2                                                         |      7  2.3|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|       2                 3                                                |     12  2.8|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                                                                          |      5  2.4|
      Lobules, Necrosis                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Fat, Necrosis                        |                                                                          |      6  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              | 2     2  1     1  2                                                      |     23  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Acinar Cell, Cytoplasmic Alteration  |                         4                                                |      8  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3|                                            |            |
                                           | 7| 1| 1| 5| 7| 0| 0| 0| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.50%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Hyperplasia, Focal      |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                         3                                                |      8  2.8|
      Erosion                              |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      4  3.0|
      Perforation                          |                         X                                                |      3     |
      Ulcer                                |                         4                                                |      9  3.6|
      Mucosa, Hyperplasia                  |                         3  3                                             |     16  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                         2                                                |      4  1.8|
      Erosion                              |                                                                          |      2  1.5|
      Ulcer                                |                         3                                                |      4  2.3|
      Epithelium, Dilatation               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    1     1     1     2                                                   |     23  1.3|
      Thrombosis                           |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                      X                                                   |      7     |
      Angiectasis                          |             2                                                            |      8  2.1|
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  1.5|
      Hyperplasia, Focal                   | 2  1                 1     2                                             |      8  1.8|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic, Focal     |          2           1  3  3                                             |     15  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3|                                            |            |
                                           | 7| 1| 1| 5| 7| 0| 0| 0| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.50%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hyperplasia                          |          1     3                                                         |      9  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          | 1                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  57        |
      Fibrosis                             |          3                                                               |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      3  2.3|
      Pars Distalis, Angiectasis           |             3  1     2                                                   |     11  2.5|
      Pars Distalis, Cyst                  | X     X        X                                                         |     23     |
      Pars Distalis, Hyperplasia           |       1  1     1                                                         |     21  1.7|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |          X                                                               |      2     |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Pars Intermedia, Hypertrophy, Focal  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                   X                                                      |      2     |
      C-Cell, Hyperplasia                  |       1           1     1                                                |     13  1.2|
      Follicle, Cyst                       |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                         2                                                |      1  2.0|
      Hyperplasia                          |       1                 2  1                                             |      4  1.3|
      Inflammation, Chronic                |                            1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |          X     X  X  X     X                                             |     17     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                                                                          |      2  2.0|
      Hyperplasia, Cystic                  |                            2                                             |      5  1.2|
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3|                                            |            |
                                           | 7| 1| 1| 5| 7| 0| 0| 0| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.50%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Prolapse                             |                                                                          |      1     |
      Endometrium, Fibrosis                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       M                 M                                                |   6        |
      Exudate                              |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Hypercellularity                     |                                                                          |      3  3.0|
      Myelofibrosis                        |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |  12        |
      Mediastinal, Hemorrhage              |                                                                          |      5  2.0|
      Mediastinal, Pigmentation            |                                                                          |      3  2.3|
      Pancreatic, Hemorrhage               |                                                                          |      3  1.3|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |          2     2     2                                                   |      8  2.0|
      Hemorrhage                           |                                                                          |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                      2     2                                             |     10  2.1|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                      1                                                   |      8  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Developmental Malformation           |                            X                                             |      1     |
      Fibrosis                             |                            1                                             |      3  1.7|
      Hematopoietic Cell Proliferation     |    1           2     2                                                   |     17  1.9|
      Pigmentation                         | 2  2  2     2     2     3  2                                             |     42  2.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3|                                            |            |
                                           | 7| 1| 1| 5| 7| 0| 0| 0| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.50%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  | 1  1  1  1  1     2  2  1  3                                             |     45  1.7|
      Hyperplasia, Lobular                 |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      4  1.5|
      Calvarium, Osteopetrosis             |    2                                                                     |     11  2.1|
      Femur, Osteopetrosis                 |                                                                          |      4  2.3|
      Sternum, Osteopetrosis               |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                      X  X  X                                             |     12     |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      4  2.5|
      Hemorrhage                           |          1                                                               |      2  1.0|
      Infiltration Cellular, Histiocyte    |          1  1     1        1                                             |     22  1.3|
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Leukocytosis                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                         1                                                |      4  1.5|
      Bronchiole, Epithelium, Hyperplasia  | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |          X  X        X                                                   |     15     |
      Foreign Body                         |                                                                          |      5  2.2|
      Fungus                               |             X                                                            |      5     |
      Mucosa, Hyperplasia                  |             3                                                            |      8  2.6|
      Mucosa, Metaplasia, Squamous         |             2                                                            |      4  1.5|
      Mucosa, Necrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3|                                            |            |
                                           | 7| 1| 1| 5| 7| 0| 0| 0| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.50%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Cataract                             |                                                                          |      5  3.2|
      Retina, Atrophy                      |                                                                          |      5  3.6|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                            +                                             |   1        |
      Ectopic Harderian                    |                            X                                             |      1     |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Suppurative            |    1     1           1                                                   |     13  1.0|
      Mineralization                       | 2  3  3  3  3  3  3  2  2  2                                             |     60  2.8|
      Nephropathy                          | 2  3  3  3  2  2  2  2  3  3                                             |     58  2.3|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      3  1.3|
      Renal Tubule, Pigmentation           |                                                                          |      6  2.5|
      Transitional Epithelium, Hyperplasia |          1                                                               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|             
                                           | 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                          X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X        X                                                      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                     4               |             
      Basophilic Focus                     | X  X  X  X     X     X  X     X     X  X     X     X     X  X  X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |    1  1  1  1  1                             3     1        1  3         |             
      Hematopoietic Cell Proliferation     |       2        1                                                         |             
      Hepatodiaphragmatic Nodule           | X              X                       X     X  X  X        X            |             
      Hyperplasia, Focal                   |    2  3                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               | 1                          1                 2                           |             
      Mixed Cell Focus                     |                                                                   X      |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1                 2        1     1  1  1              2     1           1|             
      Centrilobular, Atrophy               |                   3              2                    2                  |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                       2        3     2   |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                  2                    2                  |             
      Lobules, Necrosis                    |                   1                       2                       1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1           1  1  2  2           3     1  2        2     1     1  2  2  1|             
      Cyst                                 |             X                                                            |             
      Ectopic Liver                        |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                      3        2                          3     3     3   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|             
                                           | 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |       3                                                     3            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                3         |             
      Fibrosis                             |       4                                                                  |             
      Ulcer                                |       4                                                           3      |             
      Mucosa, Hyperplasia                  |       4                       2        1                       3  2  2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                1         |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                         3                                            2   |             
      Epithelium, Dilatation               |                         2           2        2                           |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1                          1                          1           1|             
      Thrombosis                           |                                                                          |             
      Myocardium, Inflammation, Chronic    |          1           1                                                   |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X                 X           X  X              X              X  X  X|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                       2                  |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |    2                                1     2  2     2        1            |             
      Hypertrophy, Focal                   |          1        2              3                                       |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |    1                             3                 2     2     1  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1           1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                2                                               2         |             
      Pars Distalis, Angiectasis           |                2                                               1  2      |             
      Pars Distalis, Cyst                  |                            X  X        X     X              X  X  X      |             
      Pars Distalis, Hyperplasia           |    3                                   2           2        2  3  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|             
                                           | 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Histiocyte                      |                                                             2            |             
      Pars Intermedia, Angiectasis         |                                              2                           |             
      Pars Intermedia, Cyst                |                               X                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                       1                  |             
      Ultimobranchial Cyst                 |          X                                                               |             
      C-Cell, Hyperplasia                  |    1  1  1                                                  2  2        1|             
      Follicle, Cyst                       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                      1                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X  X                 X        X                 X  X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |             2  2                             2                           |             
      Hyperplasia, Cystic                  |                                                          2               |             
      Pigmentation                         |                         2                                                |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +  +                                               M   |             
      Cyst                                 |                      X                                                   |             
      Exudate                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hypercellularity                     |                                                                          |             
      Myelofibrosis                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                   +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |             1                                                            |             
      Hyperplasia, Lymphoid                |                                                    2           3         |             
      Hyperplasia, Plasma Cell             |    2           2        2           2                          4  2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2                                                                  |             
      Hemorrhage                           |       1                                                                  |             
      Hyperplasia, Plasma Cell             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|             
                                           | 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Mast Cell     |                               3                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       3                  |             
      Hematopoietic Cell Proliferation     |    1  2  2     1                       1           1        2           2|             
      Pigmentation                         | 2  2  2     2  2     4  3  2  2  2  2  2     2  2  2     2     3  2  3  2|             
      Lymphoid Follicle, Atrophy           |                      3                                                   |             
      Red Pulp, Atrophy                    |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hemorrhage                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1  1  2  1     2  2  1  1  2     2     3           1  2  1  1  2  2  3   |             
      Hyperplasia, Lobular                 |                                                       2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3                    2                                       |             
      Exudate                              |             X                                                            |             
      Ulcer                                |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2                                               1   |             
      Calvarium, Osteopetrosis             |                   3           2                    3                    3|             
      Femur, Osteopetrosis                 |       3           3                                2                    4|             
      Sternum, Osteopetrosis               |       3           3                                2                    4|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X                                                         |             
      Developmental Malformation           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1  1                                                  1           3|             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       1                                                     1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|             
                                           | 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Exudate                              |                   X                             X                 X  X   |             
      Foreign Body                         |                   3                                                  2   |             
      Fungus                               |                   X                             X                    X   |             
      Mucosa, Hyperplasia                  |                   2              1              2                        |             
      Mucosa, Metaplasia, Squamous         |                                                 3                    2   |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Cataract                             | 3                                                                        |             
      Hemorrhage                           |                                                                          |             
      Retina, Atrophy                      | 4                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                    1                          1     1  1        1   |             
      Mineralization                       | 3  3  3  3  3  3  3  3  3  2  3  3  2  3  3  3  3  3  3  3  3  3  3  3  3|             
      Nephropathy                          | 2  3  3  3  2  3  2  4  4  2  4  2  2  3  2  2  1  3  2  4  3  2  3  4  3|             
      Interstitial Tissue, Pigmentation    |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                  2                    2                  |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                                  2                    2                  |             
      Transitional Epithelium, Hyperplasia |                      1  1     2        1                 2  1           1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|             
                                           | 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                              X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X           X                       X                                 |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2           2                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X        X  X        X  X  X     X  X  X  X  X  X|             
      Clear Cell Focus                     |                                                                         X|             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            | 2  3              1              1  1     1  1                           |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Hepatodiaphragmatic Nodule           |       X                                   X  X                           |             
      Hyperplasia, Focal                   |                   2     3              2                                 |             
      Hyperplasia, Lymphoid                |                                           1                              |             
      Inflammation, Subacute               |          1                          1                 1                  |             
      Mixed Cell Focus                     | X                                                                        |             
      Thrombosis                           |                   X                                                      |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |       1           1  1     3              1                 1            |             
      Centrilobular, Atrophy               |                      2     3           1                                 |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                                                         |             
      Kupffer Cell, Hyperplasia            |                               3                                          |             
      Kupffer Cell, Pigmentation           |                               2                                          |             
      Lobules, Necrosis                    |          1                 1           1                          2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                            +  +        +   |             
      Accessory Spleen                     |                                                                      X   |             
      Fat, Necrosis                        |             3                                            3  3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                       1     1        1           1     4  2     2      |             
      Cyst                                 |                                                                          |             
      Ectopic Liver                        |                                  X                                       |             
      Acinar Cell, Cytoplasmic Alteration  | 2              3                                   3                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|             
                                           | 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                3                          2                              |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                 2                        |             
      Fibrosis                             |                                                                          |             
      Ulcer                                |             2  2              3                 2                        |             
      Mucosa, Hyperplasia                  |             3  4  1                                3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            4  1                 2  1              2      |             
      Inflammation, Chronic                |             2                                                            |             
      Mineralization                       |             1                                                            |             
      Ulcer                                |                   3                                                      |             
      Epithelium, Dilatation               |                                                    1  2                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +                                                                 +   |             
      Hyperplasia                          |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                                1                 1                 1   |             
      Thrombosis                           |                                                                   X      |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Mineralization           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | X     X           X                             X                    X   |             
      Angiectasis                          | 2                                                     2                  |             
      Basophilic Focus                     |                                              X                           |             
      Congestion                           |                                                                   3      |             
      Hyperplasia, Diffuse                 |                               3                                          |             
      Hyperplasia, Focal                   |                               1                          1               |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                               1     1           1                       2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         | 2                             1                          2               |             
      Pars Distalis, Angiectasis           |                                           3                       3  3   |             
      Pars Distalis, Cyst                  | X     X                       X           X        X              X     X|             
      Pars Distalis, Hyperplasia           | 3     3              2           2        1           2  1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|             
                                           | 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Histiocyte                      |                                                                          |             
      Pars Intermedia, Angiectasis         | 2                                      3                                 |             
      Pars Intermedia, Cyst                |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                   1                                                      |             
      Ultimobranchial Cyst                 |                                           X  X                           |             
      C-Cell, Hyperplasia                  |                2     2           1        1  1           1               |             
      Follicle, Cyst                       |       X                                         X                       X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2     2                       3                           |             
      Inflammation, Chronic                | 2  2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X        X              X  X     X     X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                       1                  |             
      Hyperplasia, Cystic                  |                                                                          |             
      Pigmentation                         |                               1           2                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +              +           M                             +            |             
      Cyst                                 |                                                                          |             
      Exudate                              |    X                                                                     |             
      Hyperplasia                          |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hypercellularity                     |                                                                2         |             
      Myelofibrosis                        |                                     2                                1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                 +                 +        +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    2                     |             
      Hemorrhage                           |                                     2                                    |             
      Hyperplasia, Lymphoid                |                   2                                2                     |             
      Hyperplasia, Plasma Cell             | 2           2                    2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|             
                                           | 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                        3        1                 2      |             
      Hematopoietic Cell Proliferation     |                      2  2     1           2                    3        1|             
      Pigmentation                         | 2  3  2  2     2  3     3        2        2  2  3  2  2     2        3  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  1  1  2  2  1  2     2  2  1     2  2  1  2  1  2  2  1  1  1  1  3|             
      Hyperplasia, Lobular                 |             3                                1     2        2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          2                          3                                    |             
      Exudate                              |                                                                          |             
      Ulcer                                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   1                             1                       1|             
      Calvarium, Osteopetrosis             |    2           3              3                    3                    2|             
      Femur, Osteopetrosis                 |          3     3                                                        3|             
      Sternum, Osteopetrosis               |          3     3                                                        3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X        X     X                    X                    X  X         |             
      Developmental Malformation           |                                                                          |             
      Hemorrhage                           |             3                 2                                          |             
      Hydrocephalus                        |    2        2                                               2            |             
      Necrosis                             |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Infiltration Cellular, Histiocyte    | 2        1  2        2     2                 1     1        1           1|             
      Inflammation, Subacute               |             1                                                            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|             
                             DAY ON TEST   | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|             
                                           | 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.00%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Exudate                              |             X           X     X  X              X  X           X  X      |             
      Foreign Body                         |    2                                               3              2      |             
      Fungus                               |    X        X                    X                                       |             
      Mucosa, Hyperplasia                  |    3        2                                      3              2      |             
      Mucosa, Metaplasia, Squamous         |             2                    1                                       |             
      Mucosa, Necrosis                     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +        +                                                  +     +      |             
      Cataract                             | 1        3                                                        3      |             
      Hemorrhage                           |                                                                   3      |             
      Retina, Atrophy                      |          4                                                  3     3      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1              1  2     1                    1  1                       1|             
      Mineralization                       | 2  3  3  3  3  3  3  1  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  2|             
      Nephropathy                          | 3  2  2  3  3  4  4  1  3  2  3  3  2  3  2  3  4  3  1  2  3  2  1  2  3|             
      Interstitial Tissue, Pigmentation    |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                             3            |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                      2                 2                       2         |             
      Transitional Epithelium, Hyperplasia |                   2           1              1  1  2                    1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 6| 6| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0|                                            |            |
                                           | 5| 7| 7| 0| 3| 5| 7| 0| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.00%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |             X                                                            |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    | X                                                                        |      6     |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      4  2.5|
      Basophilic Focus                     | X        X  X  X  X  X  X  X                                             |     46     |
      Clear Cell Focus                     |          X                                                               |      2     |
      Eosinophilic Focus                   | X                                                                        |      1     |
      Granuloma                            |                   3                                                      |     17  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Hepatodiaphragmatic Nodule           |    X  X  X  X        X                                                   |     15     |
      Hyperplasia, Focal                   |                                                                          |      5  2.4|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      6  1.2|
      Mixed Cell Focus                     |                                                                          |      2     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Cyst                      |                         X                                                |      1     |
      Bile Duct, Hyperplasia               |       3           1                                                      |     17  1.4|
      Centrilobular, Atrophy               |       3                                                                  |      7  2.3|
      Centrilobular, Necrosis              |             1                                                            |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|       3  2  2                                                            |      7  2.3|
      Kupffer Cell, Hyperplasia            |          3                                                               |      2  3.0|
      Kupffer Cell, Pigmentation           |       3                 2                                                |      5  2.2|
      Lobules, Necrosis                    |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   6        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                            3                                             |      5  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    3                                                                     |     23  1.7|
      Cyst                                 | X           X                                                            |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 6| 6| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0|                                            |            |
                                           | 5| 7| 7| 0| 3| 5| 7| 0| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.00%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ectopic Liver                        |                                                                          |      1     |
      Acinar Cell, Cytoplasmic Alteration  |                         2                                                |      9  2.7|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                         2                                                |      3  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                            3                                             |      5  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      2  2.5|
      Fibrosis                             |                2                                                         |      2  3.0|
      Ulcer                                |          4     1           3                                             |      9  2.7|
      Mucosa, Hyperplasia                  |          3                 3                                             |     12  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |          3              2                                                |      8  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      3  2.7|
      Epithelium, Dilatation               |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1        1     1        1                                                |     12  1.0|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Inflammation, Chronic    |                                                                          |      2  1.0|
      Myocardium, Mineralization           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |    X                    X                                                |     15     |
      Angiectasis                          |             3                                                            |      4  2.3|
      Basophilic Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      2  2.5|
      Hyperplasia, Diffuse                 |             3                                                            |      2  3.0|
      Hyperplasia, Focal                   |    1                                                                     |      9  1.4|
      Hypertrophy, Focal                   |                                                                          |      3  2.0|
      Vacuolization Cytoplasmic, Diffuse   |             4                                                            |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |                      1     1                                             |     13  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  I  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 6| 6| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0|                                            |            |
                                           | 5| 7| 7| 0| 3| 5| 7| 0| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.00%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |          1                                                               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                         1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pigmentation                         |       2                                                                  |      6  1.8|
      Pars Distalis, Angiectasis           |                                                                          |      6  2.3|
      Pars Distalis, Cyst                  | X  X  X           X     X                                                |     19     |
      Pars Distalis, Hyperplasia           | 1  2              2     1  1                                             |     18  1.9|
      Pars Distalis, Infiltration Cellular,|                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      3  2.3|
      Pars Intermedia, Cyst                |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Ultimobranchial Cyst                 |                                                                          |      3     |
      C-Cell, Hyperplasia                  |                   1                                                      |     13  1.3|
      Follicle, Cyst                       |          X  X                                                            |      6     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      4  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | X           X     X  X  X                                                |     17     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                   2                                                      |      5  1.8|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   6        |
      Cyst                                 |                                                                          |      1     |
      Exudate                              |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 6| 6| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0|                                            |            |
                                           | 5| 7| 7| 0| 3| 5| 7| 0| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.00%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                         3                                                |      1  3.0|
      Hypercellularity                     |                                                                          |      1  2.0|
      Myelofibrosis                        |       4                 2                                                |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |    2                                                                     |      2  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
      Hyperplasia, Plasma Cell             |             2  2  2                                                      |     12  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |             1              1                                             |      3  1.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |       3                                                                  |      5  2.4|
      Hematopoietic Cell Proliferation     | 1           1                                                            |     16  1.6|
      Pigmentation                         | 2  3     3  2  3  2  3  3                                                |     44  2.3|
      Lymphoid Follicle, Atrophy           |                         3                                                |      2  3.0|
      Red Pulp, Atrophy                    |                         3                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
      Ectopic Parathyroid Gland            |                X                                                         |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  | 2  2  2  3  3  2  2  3  1  2                                             |     51  1.7|
      Hyperplasia, Lobular                 |             3                                                            |      6  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      4  2.5|
      Exudate                              |                                                                          |      1     |
      Ulcer                                |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 6| 6| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0|                                            |            |
                                           | 5| 7| 7| 0| 3| 5| 7| 0| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.00%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Calvarium, Osteopetrosis             |                3                                                         |     10  2.7|
      Femur, Osteopetrosis                 |                4                                                         |      8  3.1|
      Sternum, Osteopetrosis               |                4                                                         |      8  3.1|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |             X  X     X                                                   |     10     |
      Developmental Malformation           |          X                                                               |      1     |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hydrocephalus                        |             2                                                            |      4  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1                    1  1  1                                             |     17  1.4|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              | X              X        X                                                |     15     |
      Foreign Body                         |                2        2                                                |      7  2.3|
      Fungus                               | X              X        X                                                |      9     |
      Mucosa, Hyperplasia                  | 2                                                                        |      8  2.1|
      Mucosa, Metaplasia, Squamous         | 2              1        1                                                |      7  1.7|
      Mucosa, Necrosis                     |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Cataract                             |                                                                          |      4  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                1     1  1  1                                             |     17  1.1|
      Mineralization                       | 2  3  3  2  3  3  3  3  3  3                                             |     60  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 6| 7| 6| 6| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0|                                            |            |
                                           | 5| 7| 7| 0| 3| 5| 7| 0| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.00%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 2  1  3  4  3  4  2  4  4  4                                             |     60  2.7|
      Interstitial Tissue, Pigmentation    |       3                                                                  |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration |       3                                                                  |      4  2.5|
      Renal Tubule, Hyperplasia            |          1                                                               |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      5  2.0|
      Transitional Epithelium, Hyperplasia |          2     2     1  1                                                |     17  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|             
                                           | 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                   X                 X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X              X                 X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                                             |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Mucosa, Hyperplasia, Diffuse         |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                                             |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                               |             
      Basophilic Focus                     |          X  X        X              X     X           X     X            |             
      Clear Cell Focus                     |          X        X  X                                                   |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                1                       1     1           1               |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                           X           X                  |             
      Hyperplasia, Focal                   |    2  2                                            4                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                1                                                         |             
      Mixed Cell Focus                     |                   X        X        X     X                              |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 3  1     1     2  2  1     1  2     1  1  1  2  1  4  1  1     1  3  1  3|             
      Centrilobular, Atrophy               | 2                             2  3                 2              3      |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                 2           2              2  2        3|             
      Kupffer Cell, Pigmentation           |                                  2                                       |             
      Lobules, Necrosis                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +           +        +        +|             
      Fat, Hemorrhage                      |                                                       4                  |             
      Fat, Necrosis                        |                                           2           2        2        3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|             
                                           | 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              | 3  3              1  3  2     3           3  2  1  2  1  1     1  3     1|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                      3                                                   |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |             3     3                                         3            |             
      Acinar Cell, Hyperplasia, Focal      |          2  2  2                                         2  1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Acinar Cell, Cytoplasmic Alteration  |                3                                         4               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             1                                               3            |             
      Erosion                              |                            1                                             |             
      Hyperplasia                          |                                                             1            |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |             3                                               3            |             
      Mucosa, Hyperplasia                  |             3        2     1                 2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Edema                                |             2                                2              2            |             
      Erosion                              |       2     2           1        3           3                    2     3|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                      3                                2                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                             +  +         |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Chronic Active         |                                                             1  1         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     1        3  3     1        2  2  2  2        3  3     1  2      |             
      Thrombosis                           |                                                                         X|             
      Myocardium, Mineralization           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         X  X  X           X              X     X         |             
      Atrophy                              |    3                                                                     |             
      Congestion                           |                                                       4                  |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Diffuse                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|             
                                           | 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |          1        3                             1        1        1      |             
      Hypertrophy, Focal                   |                               2  2                                       |             
      Pigmentation                         |                                  3                                       |             
      Vacuolization Cytoplasmic, Diffuse   |                                              3        4        2         |             
      Vacuolization Cytoplasmic, Focal     |          1     1  3                                         2            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2           2        3  1  2     1        1  2     1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1     2              1                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                3                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                        X     X                           |             
      Pars Distalis, Hyperplasia           |                            1                             3               |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                     2                                    |             
      C-Cell, Hyperplasia                  |    2     1                                2              1               |             
      Follicle, Cyst                       |                   X                                      X               |             
      Follicular Cell, Hyperplasia         |                   1                    1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                X                    X     X        X     X               |             
      Hypospermia                          | X  X     X     X     X     X  X  X  X     X           X  X        X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1                 2  1     1     2  2        2        2  2     2         |             
      Inflammation, Suppurative            |                                                 2                    1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |          2  3                       2                          3         |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                     2                                    |             
      Hyperplasia, Lymphoid                |          2  2                                   2                    2   |             
      Inflammation, Suppurative            | 1  3  2  3  2  1  2  2  3  2     2  2  2  3  2  3  3     3  4  2  1  2  2|             
      Epithelium, Hyperplasia              |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|             
                                           | 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Spermatocele                         |                                                             X            |             
      Interstitial Cell, Hyperplasia       |                            2                       1                 2   |             
      Seminiferous Tubule, Atrophy         |    3     4                 3     1  4     3                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Myelofibrosis                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +                 +  +  +              +  +           +     +|             
      Mediastinal, Hemorrhage              |                                     3                 2                  |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Pigmentation            |                                     3                                    |             
      Pancreatic, Ectasia                  | 2                                                                        |             
      Renal, Hemorrhage                    |             2                                                            |             
      Renal, Pigmentation                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 3              2         |             
      Hemorrhage                           |                            1  3                       2                  |             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Hyperplasia, Plasma Cell             | 2                                   2           2           2  3         |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                      3                                                   |             
      Hyperplasia, Lymphoid                |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                  X                                       |             
      Fibrosis                             |          2                 2  3                                          |             
      Hematopoietic Cell Proliferation     |                      2     2  3                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             | 4                                                                 3      |             
      Pigmentation                         | 2  2        3     2              2                          3  2         |             
      Lymphoid Follicle, Atrophy           |                   2                                                      |             
      Red Pulp, Atrophy                    |             3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    1     1  3     4              2  2           1           2  4        1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|             
                                           | 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lobular                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1              2                           |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Exudate                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2        2     2  2                                3                  |             
      Femur, Osteopetrosis                 |                                  2                                       |             
      Sternum, Osteopetrosis               |                                  1                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X     X        X     X        X  X     X                 X  X         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                             2            |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    |          2        1              2     2  2                    1         |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          3                          3  2  2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X  X        X  X     X                 X        X     X     X  X  X     X|             
      Foreign Body                         |                2                                      2     2  3        2|             
      Fungus                               | X  X           X                                            X  X  X     X|             
      Mucosa, Hyperplasia                  |    2           2                                2     2     2  3  2      |             
      Mucosa, Metaplasia, Squamous         |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                         +                    +         |             
      Cataract                             | 3                                         3                    3         |             
      Retina, Atrophy                      | 4                                         4                    4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  2           1                          1              2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|             
                                           | 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       | 1  1           1           1     1  1              1  2        1  1     1|             
      Nephropathy                          | 2  4  2  3  4  3  4  4  3  3  3  2  3  2  3  2  2  3  4  3  4  3  3  2  2|             
      Renal Tubule, Hyperplasia            |                                                             1            |             
      Renal Tubule, Pigmentation           | 4                             3                    3                    2|             
      Transitional Epithelium, Hyperplasia |    2     1  2     2  1        1           2        1  2  2  2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       3                                                                  |             
      Hemorrhage                           |       2                                                                  |             
      Inflammation, Suppurative            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|             
                             DAY ON TEST   | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|             
                                           | 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X  X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Edema                                | 2                                                                        |             
      Erosion                              | 2                                                                        |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Basophilic Focus                     |    X                                            X  X                 X   |             
      Clear Cell Focus                     |                            X                                            X|             
      Congestion                           |       4                                                                  |             
      Degeneration, Cystic                 |                         1  2                 3     2     2  2            |             
      Eosinophilic Focus                   |                            X  X                                          |             
      Granuloma                            |    1                                      1                              |             
      Hematopoietic Cell Proliferation     |       2                                      2           2               |             
      Hepatodiaphragmatic Nodule           |    X  X           X              X        X     X                       X|             
      Hyperplasia, Focal                   |                                                          3  2     1  2  3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |                         X                                                |             
      Bile Duct, Cyst                      |                X                                                         |             
      Bile Duct, Hyperplasia               | 2  1  2     1  3     1  3  2  1  2  1  2  2     1  1  1  3  3     3  3  2|             
      Centrilobular, Atrophy               | 3                 3                                                  2   |             
      Hepatocyte, Vacuolization Cytoplasmic| 3     2  2        3  1                 3           1     2               |             
      Kupffer Cell, Pigmentation           |                3  2                                                      |             
      Lobules, Necrosis                    | 3                       1                                               3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|             
                             DAY ON TEST   | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|             
                                           | 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    3  3     2     2  2  2     1        2     3  1  1  1              1  1|             
      Cyst                                 |                                        X                                 |             
      Fibrosis                             |                                                                          |             
      Focal Cellular Change                |                                                             X            |             
      Hyperplasia, Lymphoid                |                                                 1                        |             
      Acinar Cell, Cytoplasmic Alteration  |          3                                            2  2               |             
      Acinar Cell, Hyperplasia, Focal      |       2                          3                    3                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1                                                   |             
      Acinar Cell, Cytoplasmic Alteration  |                               4                    3  3                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       4                  |             
      Erosion                              |                         2                                                |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |    2                                                                     |             
      Ulcer                                | 4                 2              3                    2                  |             
      Mucosa, Hyperplasia                  | 3  2              3              2                    1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Edema                                |    2              2                                   2                  |             
      Erosion                              | 3                 3                    3                                 |             
      Inflammation, Chronic                |    2                                                                     |             
      Mineralization                       |    2                                                                 3   |             
      Ulcer                                |                                                                         4|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                       +                                            +|             
      Hypertrophy                          |                                                                         3|             
      Inflammation, Chronic Active         |    1                       1                                            3|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2  2  2           2     3           1                          2|             
      Thrombosis                           |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X  X  X                          X        X        X         |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                  X                                       |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse                 |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|             
                             DAY ON TEST   | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|             
                                           | 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                         2|             
      Hypertrophy, Focal                   |                                           2                       1      |             
      Pigmentation                         |                                                             3            |             
      Vacuolization Cytoplasmic, Diffuse   |                   3              2                                       |             
      Vacuolization Cytoplasmic, Focal     |       2     2  3           2              3  2  2  1  1  1               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  3           3           2  2           1     1  1  2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                             3                       2           3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2                                                                        |             
      Pars Distalis, Cyst                  | X                 X                                                      |             
      Pars Distalis, Hyperplasia           | 3                 3        1                                            1|             
      Pars Intermedia, Angiectasis         |                2                                                         |             
      Pars Intermedia, Cyst                | X                                                           X            |             
      Pars Nervosa, Hyperplasia            |                            1                                            1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                               1  1                 1        1            |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      C-Cell, Hyperplasia                  | 1  1        1     1              1           1                           |             
      Follicle, Cyst                       |                               X              X  X  X                     |             
      Follicular Cell, Hyperplasia         |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | X  X  X                 X     X                       X           X      |             
      Hypospermia                          |    X  X           X           X  X     X     X        X  X  X        X   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   3                                                  3   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    2  2        2           2  1           2  2  1                 2  3   |             
      Inflammation, Suppurative            |                   2     2           1     2                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                                              2              3            |             
      Ectasia                              |    3                          3  2                       2               |             
      Fibrosis                             |                                  2                       2               |             
      Hyperplasia, Lymphoid                |    1                 2           1        1           1     1            |             
      Inflammation, Suppurative            | 2  2  3  3  3  3     3  3  2  2  2     2  3  2     3  2  3  3  2  3  2  3|             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|             
                             DAY ON TEST   | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|             
                                           | 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  2                                       |             
      Spermatocele                         |                                                                          |             
      Interstitial Cell, Hyperplasia       |    1                 1  1  1        2              2                    1|             
      Seminiferous Tubule, Atrophy         | 2  1              4              4        3        1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Myelofibrosis                        | 3                                      2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +  +     +              +     +           +               |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        2           2     2               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |    2  2                       3  2                 2        3            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                   2      |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                           X                              |             
      Fibrosis                             |                3                             3           2  2        3   |             
      Hematopoietic Cell Proliferation     |    2  2                                                  2        2  2   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                                              4                           |             
      Pigmentation                         | 2        2  2  2           2           2  2        2                    3|             
      Lymphoid Follicle, Atrophy           |                                                                         2|             
      Red Pulp, Atrophy                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  I  +  +|             
      Hyperplasia, Cystic                  |       2  3  2  3  1        2     4           2     3     2     1        3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|             
                             DAY ON TEST   | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|             
                                           | 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             1                                                            |             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3                             2                    2                  |             
      Femur, Osteopetrosis                 |                                                                          |             
      Sternum, Osteopetrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X  X                    X        X        X     X  X  X         |             
      Hemorrhage                           |                                                    2                     |             
      Hydrocephalus                        |          2  2                    2        1        2                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                         2                     |             
      Infiltration Cellular, Histiocyte    |                   1  1                    1                       1     1|             
      Inflammation, Subacute               |                                                                1         |             
      Metaplasia, Osseous                  |                                           1                          1   |             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       X  X  X  X     X  X           X  X     X           X  X           X|             
      Foreign Body                         |       2        2        1           2  3        2        2        2      |             
      Fungus                               |       X  X  X                          X                    X           X|             
      Mucosa, Hyperplasia                  |    2     2  2  2        2  2        2  3  2  2        2  2  2           2|             
      Mucosa, Metaplasia, Squamous         |       1                                                     2           2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                               3                                          |             
      Retina, Atrophy                      |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                       1              1        1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|             
                             DAY ON TEST   | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|             
                                           | 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       | 1        1  1           1  1  1  1  1     1  1     1  1           1  1   |             
      Nephropathy                          | 2  4  3  3  3  2  3  2  2  3  2  4  2  3  3  3  3  3  4  3  2  2  2  4  2|             
      Renal Tubule, Hyperplasia            |                                  2                    2                  |             
      Renal Tubule, Pigmentation           |                                        3                    3            |             
      Transitional Epithelium, Hyperplasia |    3              1        3  1  1           2     1  2  2           2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        3                                 |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 7| 6| 7| 4| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2|                                            |            |
                                           | 0| 6| 9| 2| 0| 6| 7| 4| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |    X                                                                     |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Parasite Metazoan                    |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +                                             |  58        |
      Erosion                              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Diffuse         |             2     2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  3.0|
      Fibrosis                             |                            3                                             |      1  3.0|
      Inflammation, Chronic                |                            3                                             |      1  3.0|
      Metaplasia, Osseous                  |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                            2                                             |      3  1.3|
      Basophilic Focus                     |       X                    X                                             |     13     |
      Clear Cell Focus                     |                            X                                             |      6     |
      Congestion                           |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                         2                                                |     11  1.6|
      Eosinophilic Focus                   |                                                                          |      2     |
      Granuloma                            |                1                                                         |      3  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |     10     |
      Hyperplasia, Focal                   |                         3                                                |      9  2.4|
      Hyperplasia, Lymphoid                |    1                                                                     |      1  1.0|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                      X                                                   |      6     |
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               |       2  1  1     1  2  3  1                                             |     48  1.8|
      Centrilobular, Atrophy               |                         3                                                |      9  2.6|
      Hepatocyte, Vacuolization Cytoplasmic|                      2  3                                                |     16  2.2|
      Kupffer Cell, Pigmentation           |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 7| 6| 7| 4| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2|                                            |            |
                                           | 0| 6| 9| 2| 0| 6| 7| 4| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lobules, Necrosis                    |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Hemorrhage                      |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    1     2     1        1  2                                             |     34  1.8|
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Focal Cellular Change                |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Acinar Cell, Cytoplasmic Alteration  |             3     3                                                      |      8  2.8|
      Acinar Cell, Hyperplasia, Focal      |       2                    1                                             |     10  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.5|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |             3                                                            |      4  2.8|
      Erosion                              |                                                                          |      2  1.5|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Subacute               |                   2                                                      |      2  2.0|
      Ulcer                                |             4                                                            |      7  3.0|
      Mucosa, Hyperplasia                  |             3     2     3                                                |     12  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Edema                                |                                                                          |      6  2.0|
      Erosion                              | 3                                                                        |     11  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      4  2.5|
      Ulcer                                |             3                                                            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +                                                      |   6        |
      Hypertrophy                          |                   3                                                      |      2  3.0|
      Inflammation, Chronic Active         |                   3                                                      |      6  1.7|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |       1     2  1        2  1                                             |     26  1.9|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Mineralization           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 7| 6| 7| 4| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2|                                            |            |
                                           | 0| 6| 9| 2| 0| 6| 7| 4| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |          X        X                                                      |     14     |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      6  1.5|
      Hypertrophy, Focal                   |                                                                          |      4  1.8|
      Pigmentation                         |                         3                                                |      3  3.0|
      Vacuolization Cytoplasmic, Diffuse   |             2                                                            |      6  2.7|
      Vacuolization Cytoplasmic, Focal     |                   2  1                                                   |     16  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                   1     3  2                                             |     22  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                2                                                         |      5  1.6|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |             3     2                                                      |      8  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |                   1                                                      |      2  1.5|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |             2     1        1                                             |      9  1.8|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      2     |
      Pars Nervosa, Hyperplasia            |             1                                                            |      4  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |                                                                          |      4  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                            1                                             |     11  1.2|
      Follicle, Cyst                       |                            X                                             |      7     |
      Follicular Cell, Hyperplasia         |                            1                                             |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 7| 6| 7| 4| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2|                                            |            |
                                           | 0| 6| 9| 2| 0| 6| 7| 4| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      |       X     X           X                                                |     15     |
      Hypospermia                          |       X                    X                                             |     26     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  3.0|
      Hyperplasia                          |                         2                                                |      1  2.0|
      Inflammation, Chronic                |    2     2              2                                                |     23  1.8|
      Inflammation, Suppurative            |                   2                                                      |      7  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Corpora Amylacea                     |                            2                                             |      7  2.4|
      Ectasia                              |                                                                          |      4  2.5|
      Fibrosis                             |                                                                          |      3  2.0|
      Hyperplasia, Lymphoid                |                         2                                                |     11  1.5|
      Inflammation, Suppurative            |    1     3  2     3  1  3  2                                             |     52  2.4|
      Epithelium, Hyperplasia              |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |             1                                                            |      2  1.5|
      Spermatocele                         |                                                                          |      1     |
      Interstitial Cell, Hyperplasia       |                      1                                                   |     11  1.4|
      Seminiferous Tubule, Atrophy         |             3           3                                                |     14  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           | 4                                                                        |      1  4.0|
      Myelofibrosis                        |                1                                                         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +           +                                                |  19        |
      Mediastinal, Hemorrhage              |             3                                                            |      3  2.7|
      Mediastinal, Hyperplasia, Plasma Cell|             2                                                            |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      5  2.2|
      Hemorrhage                           |    1                                                                     |      4  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |       2        2  2  2                                                   |     15  2.2|
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 7| 6| 7| 4| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2|                                            |            |
                                           | 0| 6| 9| 2| 0| 6| 7| 4| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                            4                                             |      1  4.0|
      Hemorrhage                           |                   1                                                      |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Developmental Malformation           |                                                                          |      2     |
      Fibrosis                             |       3  2              4                                                |     11  2.6|
      Hematopoietic Cell Proliferation     |                   2                                                      |      9  2.1|
      Infiltration Cellular, Histiocyte    |                            1                                             |      1  1.0|
      Necrosis                             |                                                                          |      3  3.7|
      Pigmentation                         |          3  3     2  3  2                                                |     21  2.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.0|
      Red Pulp, Atrophy                    |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |  54        |
      Congestion                           | 3                                                                        |      1  3.0|
      Hemorrhage                           | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  +                                             |  54        |
      Hyperplasia, Cystic                  |             1     3     3  4                                             |     26  2.3|
      Hyperplasia, Lobular                 |       4                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |             1                                                            |      4  1.3|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Exudate                              |             X                                                            |      2     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |             3     1                                                      |     10  2.2|
      Femur, Osteopetrosis                 |                                                                          |      1  2.0|
      Sternum, Osteopetrosis               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |          X              X                                                |     19     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      6  1.8|
      Vacuolization Cytoplasmic            |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 7| 6| 7| 4| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2|                                            |            |
                                           | 0| 6| 9| 2| 0| 6| 7| 4| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           | 2                                                                        |      4  2.3|
      Infiltration Cellular, Histiocyte    |       1  1     1  1                                                      |     15  1.3|
      Inflammation, Subacute               |       1                                                                  |      2  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                   3                                                      |      6  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |       X  X        X  X  X  X                                             |     30     |
      Foreign Body                         |                   2  2     3                                             |     16  2.1|
      Fungus                               |          X        X  X     X                                             |     17     |
      Mucosa, Hyperplasia                  |       2           2  2     3                                             |     25  2.1|
      Mucosa, Metaplasia, Squamous         |          3           2                                                   |      6  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      4  3.0|
      Retina, Atrophy                      |                                                                          |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |             1                                                            |     10  1.2|
      Mineralization                       |       1                    1                                             |     27  1.0|
      Nephropathy                          |    3  4  3  4  3  4  2  3  2                                             |     59  2.9|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.7|
      Renal Tubule, Pigmentation           |                         3                                                |      7  3.0|
      Transitional Epithelium, Hyperplasia |       2     2     2     1                                                |     25  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|             
                             DAY ON TEST   | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|             
                                           | 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.125%                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                          X                                      X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                               X  X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   1      |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia, Diffuse         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                      4   |             
      Mucosa, Hyperplasia, Diffuse         |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                      2   |             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     2                                                            |             
      Basophilic Focus                     |       X        X           X                       X  X  X  X  X  X      |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                2        3                             1  1               |             
      Eosinophilic Focus                   |                                                                X  X      |             
      Granuloma                            |                                                             1        2   |             
      Hematopoietic Cell Proliferation     |    1                                                                     |             
      Hepatodiaphragmatic Nodule           |             X                             X                              |             
      Hyperplasia, Focal                   | 3  2  3              1                             1                     |             
      Inflammation, Subacute               |                         1                                                |             
      Mixed Cell Focus                     |                                  X                 X        X            |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  3  2  2  3  3  1  2  2        4     1  3  1  1  1  2     1  1  2  1|             
      Centrilobular, Atrophy               |                   3        2        2        2                           |             
      Centrilobular, Necrosis              |                            1                                             |             
      Hepatocyte, Vacuolization Cytoplasmic|                      2  2                 3     2  2                    1|             
      Kupffer Cell, Pigmentation           |    3                                                                     |             
      Lobules, Necrosis                    | 3                 1                       1        1           1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                    +                                       |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |    3        3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1        2  2        1  3  4  1     1           2  1  2  1     4  3  2   |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Acinar Cell, Cytoplasmic Alteration  |                         3                             3           2     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|             
                             DAY ON TEST   | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|             
                                           | 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.125%                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Hyperplasia, Focal      |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Acinar Cell, Cytoplasmic Alteration  |                                                             3            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    3                                                              2      |             
      Erosion                              |                                                                          |             
      Fibrosis                             |                                                          3               |             
      Inflammation, Subacute               |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |    3                                                              2     4|             
      Mucosa, Hyperplasia                  |    3                                                     3        2     4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                               X                                          |             
      Edema                                | 2                                                                        |             
      Erosion                              |                                        3  2                              |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                      3   |             
      Epithelium, Dilatation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     3                 1  2     1           1     2  1  1     1  1  1   |             
      Thrombosis                           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X     X        X        X              X                          X|             
      Basophilic Focus                     |                                                             X  X         |             
      Congestion                           |                            3                                             |             
      Hematopoietic Cell Proliferation     | 1                          2                                             |             
      Hyperplasia, Focal                   | 1                          2                          2                  |             
      Hypertrophy, Focal                   |                                  2                                       |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |    3                                      3           2                  |             
      Vacuolization Cytoplasmic, Focal     | 2              2                    1              2     3               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     3     2              3                 3     2  1        1  3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|             
                             DAY ON TEST   | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|             
                                           | 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.125%                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                2                                         3        2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      4   |             
      Pars Distalis, Angiectasis           |                                                    2                     |             
      Pars Distalis, Cyst                  |                            X                 X                           |             
      Pars Distalis, Hyperplasia           |             3                                2           3               |             
      Pars Distalis, Necrosis              |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                    3                     |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Hyperplasia            | 1                                            1     1           2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                              1                           |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 2     2     1                                         1        1         |             
      Follicle, Cyst                       |                            X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |             X     X              X  X                                    |             
      Hypospermia                          | X  X  X                    X              X  X     X     X  X  X         |             
                                            __________________________________________________________________________|             
   Penis                                   | +                                                                        |             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            | 4                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                | 2                 2     2     2  2  2        2  2     2  2        2     2|             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     | 2           3              2                                             |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                       3        2  3      |             
      Hyperplasia, Lymphoid                |                1                                      2           3      |             
      Inflammation, Suppurative            | 1  4  3  2  3  2  2  2  3        2  1     3           4     2  4  4  3  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   2      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          1              2  2  1     1                             1      |             
      Seminiferous Tubule, Atrophy         |    4  4                                   3           2  4     1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|             
                             DAY ON TEST   | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|             
                                           | 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.125%                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                        2                                 |             
      Myelofibrosis                        |    4              2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +     +  +     +                              |             
      Lumbar, Hyperplasia, Plasma Cell     |                                           3                              |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Pancreatic, Pigmentation             |                            4                                             |             
      Renal, Hemorrhage                    |                                           2                              |             
      Renal, Hyperplasia, Plasma Cell      |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                       3     2        2           2      |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           | 2                          1              1                              |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia, Plasma Cell             | 2     2        3           2                 3     2  3           3     2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                   3      |             
      Hemorrhage                           | 2                    3                                   2               |             
      Hyperplasia, Lymphoid                |                                                 2                    3   |             
      Pigmentation                         |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |    3  2     3  1  2        3              2        3        1            |             
      Hematopoietic Cell Proliferation     | 2  2        2     2        3                 2           2     1         |             
      Necrosis                             |    2                                                                     |             
      Pigmentation                         |       3        2  2  3  2  2  2           2  2     2  2  2  2  2     2  2|             
      Lymphoid Follicle, Atrophy           |                                           3                              |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Ectopic Thyroid                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  2              1           2              1  2  3     1  4  2     2|             
      Hyperplasia, Lobular                 |                                                          2  2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   1                                      1               |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Exudate                              |                                                                          |             
      Hyperplasia, Basal Cell              |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|             
                             DAY ON TEST   | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|             
                                           | 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.125%                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                1                                      1  3        2      |             
      Hyperostosis                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X              X                          X     X        X        X|             
      Hemorrhage                           |                      4                                                   |             
      Hydrocephalus                        |       2              2                                2                  |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Edema                                |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Infiltration Cellular, Histiocyte    |                            1              1        1              1      |             
      Inflammation, Subacute               |          1                             2                             2   |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |             X  X                             X     X  X  X     X        X|             
      Foreign Body                         |                                              2     2           3        3|             
      Fungus                               |             X  X                                   X     X     X        X|             
      Mucosa, Hyperplasia                  |             2  3                             2     2  2        3        2|             
      Mucosa, Metaplasia, Squamous         |                                                                1         |             
      Mucosa, Necrosis                     |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|             
                             DAY ON TEST   | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|             
                                           | 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.125%                                 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            | 1           1     1                                1  1     1            |             
      Mineralization                       |       1              1     2     1  1  3  1  1     1        1  1  1  1   |             
      Nephropathy                          | 2  2  3  2  3  4  3  2  3  2  3  2  3     2  3  3  3  4  4  3  4  4  2  4|             
      Renal Tubule, Hyperplasia            | 2                 1                                   1  2               |             
      Renal Tubule, Pigmentation           | 2                 3        2        2        2                           |             
      Transitional Epithelium, Hyperplasia | 2  1  2     1  2  2              2  1        1     2  1  2  1  2  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Inflammation, Suppurative            |                                        3                             1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|             
                                           | 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.125%                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X        X                                                  X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Erosion                              |             1                 1                                          |             
      Ulcer                                |                                           2                              |             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia, Diffuse         |                                                       3     2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia, Diffuse         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |             X     X  X           X  X  X                       X         |             
      Clear Cell Focus                     |                   X           X                    X                     |             
      Congestion                           |          3                                                               |             
      Degeneration, Cystic                 |                   1                       2                             2|             
      Eosinophilic Focus                   |                                     X                                    |             
      Granuloma                            |                      1                                                   |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hepatodiaphragmatic Nodule           |          X           X                       X              X     X     X|             
      Hyperplasia, Focal                   |             1  2                                                         |             
      Inflammation, Subacute               |                                                                   1      |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                                                          X               |             
      Bile Duct, Hyperplasia               | 3  2  1  1  1  4  1  1  2  3  1     1  1     1  4  1     3  1     1      |             
      Centrilobular, Atrophy               | 2              2           2                    2        3               |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|          3  1                             4           2     4        3   |             
      Kupffer Cell, Pigmentation           |                               1                 3        2              1|             
      Lobules, Necrosis                    |                            2                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +              +                     |             
      Hemorrhage                           |                                     3                                    |             
      Fat, Necrosis                        |                                     2              3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2  2  1     3     1  2  3        1        1     3  1        1  3     1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |          2  3                 4           4           3     2        4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|             
                                           | 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.125%                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Hyperplasia, Focal      |                   2           3                 2           3            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Acinar Cell, Cytoplasmic Alteration  |             4     3  4              3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3  2                 3              3           3            |             
      Erosion                              |                                                                          |             
      Fibrosis                             |                                           3                              |             
      Inflammation, Subacute               |                   2                                                      |             
      Perforation                          |                                  X                                       |             
      Ulcer                                |             3  2              3  4        4     3     4     4     3  4   |             
      Mucosa, Hyperplasia                  |             3     4           4  3        3     2     3     3     2  4  3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Edema                                |                   2                                                      |             
      Erosion                              | 1                                         2           3                  |             
      Inflammation, Chronic                |                                                             2        2   |             
      Mineralization                       |                               1     1                                    |             
      Ulcer                                |                               2                 2                        |             
      Epithelium, Dilatation               |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +  +                                    |             
      Inflammation, Chronic Active         |                                  2  2                                    |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1  2     1     2  1           2  1     2  1        2  2  1      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X           X              X  X     X     X  X              X|             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Pigmentation                         | 3                          2                                             |             
      Vacuolization Cytoplasmic, Diffuse   |                                                 2     2                  |             
      Vacuolization Cytoplasmic, Focal     |             2  1                                                  1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  1        2  1              3     1           1     1  1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|             
                                           | 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.125%                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                1  3           2  2  3                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                            X        X                                    |             
      Pars Distalis, Hyperplasia           |                               3                 1        2               |             
      Pars Distalis, Necrosis              |                            4                                             |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                | X                                               X                        |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Ultimobranchial Cyst                 |          X     X                                                         |             
      C-Cell, Hyperplasia                  |                1           1  1              1                           |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                       X  X               |             
      Hypospermia                          |          X           X        X  X  X     X                 X     X      |             
                                            __________________________________________________________________________|             
   Penis                                   |                            +                                             |             
      Edema                                |                            3                                             |             
      Inflammation, Suppurative            |                            3                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  3                                       |             
      Inflammation, Chronic                | 2     2  2  2              2     2  2        1     2     2     2         |             
      Inflammation, Suppurative            |                               2        2                                 |             
      Necrosis                             |                         2                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                                  2              2                       2|             
      Ectasia                              |                                           2                              |             
      Fibrosis                             |                                                             2            |             
      Hyperplasia, Lymphoid                | 1              2                                   1  2                  |             
      Inflammation, Suppurative            |    3  3  3  3  2  2        2  2     3  2  3  3  2  2  3  2  3  3  2  3  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                             3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    1  1  1     1                 2     1  2     1  1  3     1  2     2  1|             
      Seminiferous Tubule, Atrophy         |          3  4        4        4  4  4     2                 3     4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|             
                                           | 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.125%                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
      Myelofibrosis                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +           +     +                       +               |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hemorrhage              |                                  3                                       |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                3        2                                                |             
      Fibrosis                             |                                                 3                        |             
      Hemorrhage                           |                                        2     1                           |             
      Hyperplasia, Lymphoid                |                                     2                                   3|             
      Hyperplasia, Plasma Cell             |                   3              2  2        2     2        3     2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                           1                              |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
      Pigmentation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                X         |             
      Fibrosis                             | 3              2  3                 4           3                       2|             
      Hematopoietic Cell Proliferation     |          2           2                                                  2|             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2        2  2     3           2  2  2     3  3  2     3           3  3  2|             
      Lymphoid Follicle, Atrophy           |                                                 4                        |             
      Red Pulp, Atrophy                    |                                                 4                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thyroid                      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       3  1  3  1  3           2     2     1  3        3     2     2  2  2|             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Exudate                              |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|             
                                           | 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.125%                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             1     2           3  2  2     1                 1            |             
      Hyperostosis                         |                3                          3                              |             
      Necrosis                             |                3                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X     X        X                       X  X        X     X     X  X   |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |          2                                2  2              2            |             
      Mineralization                       |                                           3                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +                                                                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Foreign Body                         |                                                                         3|             
      Hemorrhage                           |                1                                                         |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Infiltration Cellular, Histiocyte    |    1     1     1  1  2        3                                          |             
      Inflammation, Subacute               |                                                             1            |             
      Inflammation, Suppurative            |                                     2                                   4|             
      Alveolar Epithelium, Hyperplasia     | 3                             2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X           X  X  X  X  X     X  X  X           X  X     X     X        X|             
      Foreign Body                         | 2           1  2                 2              2  2     2     3        4|             
      Fungus                               |             X  X        X           X              X     X              X|             
      Mucosa, Hyperplasia                  | 1              2        2     2  3  2           2        3  1  2        3|             
      Mucosa, Metaplasia, Squamous         |             1           1           2              2     2               |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +  +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                    +                                 |             
      Cataract                             |                   3                    3                                 |             
      Inflammation, Chronic                |                   2                                                      |             
      Retina, Atrophy                      |                   4                    4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|             
                             DAY ON TEST   | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|             
                                           | 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.125%                                 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                  2                                       |             
      Inflammation, Suppurative            |    1           1  1           1  1  2                             1  1   |             
      Mineralization                       |    1              1        1  1     1  1                 1  1     1  1  1|             
      Nephropathy                          | 2  2  3  2  4  4  4  2  3  3  4  4  4  3  4  2  3  3  4  3  4  2  3  4  3|             
      Renal Tubule, Hyperplasia            |                1  2                                               3      |             
      Renal Tubule, Pigmentation           | 3                          3                    2                        |             
      Transitional Epithelium, Hyperplasia |             2  2  3           2  1  2     1     1     2  1  2        2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 6| 5| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3|                                            |            |
                                           | 6| 4| 2| 9| 6| 4| 4| 6| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.125%                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                         X                                                |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  I  +  +  +  +  +  +  +                                             |  58        |
      Parasite Metazoan                    |                X                                                         |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  A  +  +  +     +                                             |  53        |
      Erosion                              |                                                                          |      3  1.0|
      Ulcer                                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  57        |
      Inflammation, Subacute               |                                                                          |      1  4.0|
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +                                             |  58        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     | X     X     X                                                            |     19     |
      Clear Cell Focus                     |                            X                                             |      4     |
      Congestion                           |                3                                                         |      2  3.0|
      Degeneration, Cystic                 |    1                                                                     |      8  1.6|
      Eosinophilic Focus                   |                                                                          |      3     |
      Granuloma                            |                                                                          |      3  1.3|
      Hematopoietic Cell Proliferation     |                3                                                         |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Hyperplasia, Focal                   |                                                                          |      7  1.9|
      Inflammation, Subacute               |       2                                                                  |      3  1.3|
      Mixed Cell Focus                     |                                                                          |      3     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 1  3  1  1  3     3  2  1  3                                             |     49  1.9|
      Centrilobular, Atrophy               |                2  2        2                                             |     12  2.2|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|             2  2                                                         |     14  2.4|
      Kupffer Cell, Pigmentation           |          1  2     2                                                      |      8  1.9|
      Lobules, Necrosis                    |          2                                                               |      7  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +     +                                                |   7        |
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 6| 5| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3|                                            |            |
                                           | 6| 4| 2| 9| 6| 4| 4| 6| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.125%                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Necrosis                        |                   2                                                      |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              | 1  1  2  1        3  2     1                                             |     37  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |     11  2.9|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      7  2.7|
      Erosion                              |                2                                                         |      1  2.0|
      Fibrosis                             |                         4                                                |      3  3.3|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Perforation                          |                                                                          |      1     |
      Ulcer                                |                         3                                                |     14  3.3|
      Mucosa, Hyperplasia                  |                         3                                                |     16  3.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Edema                                |                                                                          |      2  2.0|
      Erosion                              |                                                                          |      5  2.2|
      Inflammation, Chronic                |       2                                                                  |      3  2.0|
      Mineralization                       |             2                                                            |      3  1.3|
      Ulcer                                |                                                                          |      3  2.3|
      Epithelium, Dilatation               |       1                                                                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1  2     1  2           1  1                                             |     30  1.4|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | X     X  X                                                               |     17     |
      Basophilic Focus                     |                                                                          |      2     |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 6| 5| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3|                                            |            |
                                           | 6| 4| 2| 9| 6| 4| 4| 6| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.125%                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |             1        1                                                   |      5  1.4|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Pigmentation                         |                            3                                             |      3  2.7|
      Vacuolization Cytoplasmic, Diffuse   |                            3                                             |      6  2.5|
      Vacuolization Cytoplasmic, Focal     |                         3                                                |      9  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          2     1  2                                                      |     21  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  56        |
      Hyperplasia                          |             2                                                            |      9  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |                   2                                                      |      7  2.3|
      Pars Distalis, Necrosis              |                                                                          |      1  4.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                                          |      2     |
      Pars Nervosa, Hyperplasia            |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |                                                                          |      9  1.2|
      Follicle, Cyst                       |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      | X              X     X                                                   |      9     |
      Hypospermia                          |             X     X     X  X                                             |     22     |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |             3  3                                                         |      3  3.0|
      Inflammation, Chronic                |                      1  2  2                                             |     26  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 6| 5| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3|                                            |            |
                                           | 6| 4| 2| 9| 6| 4| 4| 6| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.125%                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            | 2  2           2                                                         |      5  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Corpora Amylacea                     |                            2                                             |      7  2.1|
      Ectasia                              |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      4  2.5|
      Hyperplasia, Lymphoid                |          1                                                               |      8  1.6|
      Inflammation, Suppurative            |    2  2  3  3  2  1  1  3  2                                             |     48  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Interstitial Cell, Hyperplasia       |                                                                          |     20  1.4|
      Seminiferous Tubule, Atrophy         |    3              3        4                                             |     18  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     |                                                                          |      1  2.0|
      Myelofibrosis                        |             2                                                            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  11        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +                                             |  58        |
      Ectasia                              |    2           3                                                         |      9  2.3|
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           | 2                                                                        |      6  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |    3              2     2                                                |     19  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      4  2.0|
      Hyperplasia, Lymphoid                |       2                                                                  |      4  2.5|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 6| 5| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3|                                            |            |
                                           | 6| 4| 2| 9| 6| 4| 4| 6| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.125%                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |             2  4                                                         |     17  2.5|
      Hematopoietic Cell Proliferation     |                            2                                             |     12  2.0|
      Necrosis                             |                3                                                         |      2  2.5|
      Pigmentation                         |    2  2  2  2           2                                                |     35  2.2|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  3.5|
      Red Pulp, Atrophy                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectopic Thyroid                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Hyperplasia, Cystic                  |    1  1  3              3  2                                             |     30  2.1|
      Hyperplasia, Lobular                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                2                                                         |      3  1.3|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Exudate                              |                X                                                         |      1     |
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |    1        2  1                                                         |     14  1.6|
      Hyperostosis                         |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |       X  X              X                                                |     18     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrocephalus                        |       2  2              2                                                |     10  2.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 6| 5| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3|                                            |            |
                                           | 6| 4| 2| 9| 6| 4| 4| 6| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.125%                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |                                                                          |      1  3.0|
      Hemorrhage                           | 1                                                                        |      2  1.0|
      Hyperplasia, Lymphoid                |             2                                                            |      3  2.3|
      Infiltration Cellular, Histiocyte    |       1     3                                                            |     12  1.4|
      Inflammation, Subacute               |       1                                                                  |      5  1.4|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |    X        X  X  X                                                      |     26     |
      Foreign Body                         |    3        2     2  2                                                   |     17  2.3|
      Fungus                               |    X        X  X  X                                                      |     17     |
      Mucosa, Hyperplasia                  |    3        3  2  2  2     1                                             |     24  2.2|
      Mucosa, Metaplasia, Squamous         |    2           2  1                                                      |      9  1.6|
      Mucosa, Necrosis                     |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   3        |
      Cataract                             |    4                                                                     |      3  3.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Retina, Atrophy                      |    4                                                                     |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Suppurative            |    1     1        1        1                                             |     18  1.1|
      Mineralization                       | 1  1  1  1  1           1                                                |     30  1.1|
      Nephropathy                          | 2  4  2  3  4  4  3  3  3  3                                             |     59  3.1|
      Renal Tubule, Hyperplasia            |                                                                          |      7  1.7|
      Renal Tubule, Pigmentation           |                            3                                             |      9  2.4|
      Transitional Epithelium, Hyperplasia |    2        2  1  2     2                                                |     32  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|             
                             DAY ON TEST   | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|             
                                           | 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X        X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                    X                     |             
      Erosion                              |                                        1     2                           |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |                                        2                 2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2     1                                                      |             
      Basophilic Focus                     | X  X     X  X     X  X        X  X     X                 X               |             
      Clear Cell Focus                     | X                                                                        |             
      Congestion                           |                                     2                                    |             
      Degeneration, Cystic                 |    2                                            2              1         |             
      Granuloma                            | 2     1              1              1                                    |             
      Hemorrhage                           |    2                                                                     |             
      Hepatodiaphragmatic Nodule           |                X                    X                                    |             
      Hyperplasia, Focal                   |                                                                2         |             
      Hyperplasia, Lymphoid                |                         1                                                |             
      Inflammation, Subacute               |                   1  1                    1                 2            |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Cyst                      |                                                                   X      |             
      Bile Duct, Hyperplasia               | 1  3  1  4  1           1  1     1     1  1  1  1  1  2  1  1  2  3  1   |             
      Centrilobular, Atrophy               |    3                                2                             2      |             
      Centrilobular, Necrosis              |                                                       3                 3|             
      Hepatocyte, Vacuolization Cytoplasmic|       1                             3        3        3           2      |             
      Kupffer Cell, Pigmentation           |          3     1                          1                       2      |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                          +                 +|             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |          3                 2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  1  2     2     2  1        2        4     2  2           2        2|             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                            3           3     3           3        3      |             
      Acinar Cell, Hyperplasia, Focal      |                   3        2                 2     2           3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|             
                             DAY ON TEST   | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|             
                                           | 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                1         |             
      Acinar Cell, Cytoplasmic Alteration  |          3                                               3               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Ulcer                                |                                     4        3        4  4               |             
      Mucosa, Hyperplasia                  |                                     3        4                 1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                        2              3        3        2|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                         2                    3        3  1        2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1           1  1     2  1        2  1  1  1           1  3         |             
      Thrombosis                           |                                                                          |             
      Myocardium, Mineralization           |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X     X     X                 X        X     X     X  X  X            |             
      Hyperplasia, Focal                   | 1     2        2           2                                             |             
      Hypertrophy, Focal                   |             1                                                     2      |             
      Pigmentation                         |                                                                   3      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          2     2                                2        1     3  2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2        1  1        2        1                 3     3  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                        2                       2         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                      2        1                    1                     |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|             
                             DAY ON TEST   | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|             
                                           | 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                               1                                          |             
      Follicle, Cyst                       |             X                    X                             X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                   X                    X                          X  X   |             
      Hypospermia                          |          X     X              X                 X        X     X         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
      Inflammation, Suppurative            |                                                                   1      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |    2  2  2     2                    2     1                              |             
      Inflammation, Suppurative            |                      2           1  3        2                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                   2                                      2               |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1     1               |             
      Inflammation, Suppurative            | 2     3  3  3  1     2  3  3  3     2        3  2     2  2     2  2  3   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia       |                      1                                1        1  2      |             
      Seminiferous Tubule, Atrophy         |                3                                         3     3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                         3|             
      Myelofibrosis                        |                                                 3                 3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                            +           +      |             
      Mediastinal, Hemorrhage              |                                                       3                  |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Necrosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |          2                    2                                          |             
      Hemorrhage                           |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|             
                             DAY ON TEST   | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|             
                                           | 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                    2        3                     |             
      Hyperplasia, Plasma Cell             | 2              2  4           2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                     3                                    |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Lymphoid                |       2                                   2        3        3            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                  X                                       |             
      Fibrosis                             |          4                                2                    3  2      |             
      Hematopoietic Cell Proliferation     |    2                                                  3                 3|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    2  2        2  2  2  2           2  2  2  2           2  3  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       3  2  3  3  2     3  2        2        3           2  3  2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 2                        |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Exudate                              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                        3                 1     2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X  X  X  X        X           X        X              X        X   |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |       2     2  2        2           3        2                           |             
      Vacuolization Cytoplasmic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                1                                   1     2               |             
      Inflammation, Subacute               |                                                                          |             
      Leukocytosis                         |                                                                         2|             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|             
                             DAY ON TEST   | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|             
                                           | 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X  X     X  X  X           X  X           X  X     X  X  X     X         |             
      Foreign Body                         | 2              2           3  2                          3     2         |             
      Fungus                               |    X     X  X  X           X  X           X  X     X     X               |             
      Mucosa, Hyperplasia                  |    2     3     2           4  2              3     4     3     3         |             
      Mucosa, Metaplasia, Squamous         | 2                          4              3  2     2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2        1  1                 1                        |             
      Mineralization                       |       1  2     1        1  2  1  2  1        1  2     1  1  1  1  1     2|             
      Nephropathy                          | 3  2  3  3  2  3  3  2  2  3  3  3  3  4  3  4  4  3  2  4  2  4  3  2  1|             
      Renal Tubule, Cytoplasmic Alteration |    3                                                                     |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                1                                                         |             
      Renal Tubule, Pigmentation           |    3     3                                                        3      |             
      Transitional Epithelium, Hyperplasia |          2        3        1           3     1  2        3     2  2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Dilatation                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia                  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|             
                             DAY ON TEST   | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|             
                                           | 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                       X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                 X              X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Erosion                              |       2                          2        2  2                       2   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3        2                                       |             
      Basophilic Focus                     | X  X  X        X        X  X  X        X                 X           X  X|             
      Clear Cell Focus                     |          X                                                               |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                         2  2     3                 2                     |             
      Granuloma                            | 1                                                     1                  |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           | X  X                 X                                                   |             
      Hyperplasia, Focal                   |                2                                            1            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |                         X     X                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  1  2  1  1     1  1  1  1  1  1           3  3  2  3  2  1     1  2|             
      Centrilobular, Atrophy               |                                                 3                        |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|          4           2  2        2  2        2        3                  |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |          2                                            1           4      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                          +                 +  +           +            |             
      Accessory Spleen                     |                                                             X            |             
      Fat, Necrosis                        | 3                                            3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     1              3  1  2  3              2  2  1  1  4     3  1  2   |             
      Focal Cellular Change                |                                                    X                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |    2     3                 2     3        4                          2   |             
      Acinar Cell, Hyperplasia, Focal      | 1                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|             
                             DAY ON TEST   | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|             
                                           | 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              | 1                                                                        |             
      Acinar Cell, Cytoplasmic Alteration  |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    3                                                                 3   |             
      Erosion                              |                                                                          |             
      Fibrosis                             |                                  2                                       |             
      Ulcer                                |          3                                                           4   |             
      Mucosa, Hyperplasia                  |          2                                         1                 2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2                                2  2   |             
      Erosion                              |                               1              2                           |             
      Mineralization                       |    3                                                                     |             
      Ulcer                                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2     1  1  1     3  2     1  2  3           2  2     2  2        1|             
      Thrombosis                           |                                              X                           |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X                                         X     X            |             
      Hyperplasia, Focal                   |       2           1                                                      |             
      Hypertrophy, Focal                   |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |    2     2                 2                                             |             
      Vacuolization Cytoplasmic, Focal     |                1     1        1     1              1     3           1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3           1        3  3  1  2                 3     3           1  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2              2  3  2           3              2           2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2                    1        1                 3                 1   |             
      Pars Intermedia, Cyst                |    X                                                                     |             
      Pars Nervosa, Hyperplasia            |                1                                1  1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|             
                             DAY ON TEST   | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|             
                                           | 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ultimobranchial Cyst                 |                                  X                                       |             
      C-Cell, Hyperplasia                  |             1                                                            |             
      Follicle, Cyst                       |                   X           X  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                X           X  X           X  X  X  X                     |             
      Hypospermia                          |    X  X  X        X  X  X        X     X                 X        X  X   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              3                           |             
      Inflammation, Chronic                | 2     2     2  2  2     2  2  2     2     2           2           2     2|             
      Inflammation, Suppurative            |                                                          2               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |          2              2  2  2                                          |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                          4               |             
      Hyperplasia, Lymphoid                |                1     1     2                             3              1|             
      Inflammation, Suppurative            | 2  3  1     1  3     2  3  2     2  2     2  3     2  3  4  2  2     2  2|             
      Epithelium, Hyperplasia              |    3                                                     3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                          4               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           2                              |             
      Interstitial Cell, Hyperplasia       |             3              2        1        1        1                  |             
      Seminiferous Tubule, Atrophy         |    3     3           2  1        4        1              4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                   2                                               2  2   |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                          +  +  +     +        +      |             
      Mediastinal, Hemorrhage              |                   3                                                      |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Necrosis                |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Ectasia                              |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|             
                             DAY ON TEST   | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|             
                                           | 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            2  2                       2           3      |             
      Hyperplasia, Plasma Cell             |          2              2              2              2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                   2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               2     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |    2                    2     3  3              2  3     2               |             
      Hematopoietic Cell Proliferation     |       2  2        2                    2                          2  2  2|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    3  2                       2        2           2  3  2  2           3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3        3     1                                1     2  4  3           3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             1                                                            |             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3  1  2              3  2  2  2        2        1                 2   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X        X           X                                X  X  X           X|             
      Granuloma                            |          2                                                               |             
      Hemorrhage                           |                                                             2            |             
      Hydrocephalus                        | 2        2                                            2                 2|             
      Vacuolization Cytoplasmic            |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2  3     2            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           1              3               |             
      Infiltration Cellular, Histiocyte    |                                  1        1        1                     |             
      Inflammation, Subacute               |       3     1     1        2        1  1                                 |             
      Leukocytosis                         |                                                                          |             
      Metaplasia, Osseous                  |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|             
                             DAY ON TEST   | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|             
                                           | 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       2              2     2                       3     3               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       X     X     X     X  X     X  X  X  X        X  X     X  X  X      |             
      Foreign Body                         |             2     2        2              2           1     2     2      |             
      Fungus                               |                   X     X  X     X  X  X  X           X           X      |             
      Mucosa, Hyperplasia                  |       2     2     2     3  3     2  2  3  3        2  2           2      |             
      Mucosa, Metaplasia, Squamous         |                                  2     2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Cataract                             |                                                             3            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1           1  1  1        2     1|             
      Mineralization                       |    1  1  1        1  1           1  2     1  2     3  1     1  1  2      |             
      Nephropathy                          | 3  4  4  4  3  4  2  3  4  4  4  4  3  3  4  2  2  3  3  4  3  2  2  4  3|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Hyperplasia            |    2                       2              2                          2   |             
      Renal Tubule, Hyperplasia, Oncocytic |                      2                                                   |             
      Renal Tubule, Pigmentation           |                                              3  2                        |             
      Transitional Epithelium, Hyperplasia | 1  2  2  1     2     1  2  3  3  2     3  2  3  3  2  2  2        1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |                3                                                         |             
      Inflammation, Subacute               |                                                          2               |             
      Mucosa, Hyperplasia                  |                                                          3              1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 6| 6| 6| 4| 4| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7|                                            |            |
                                           | 0| 0| 6| 1| 3| 8| 6| 9| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.25%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |       X                                                                  |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +                                             |  55        |
      Ectopic Tissue                       |                                                                          |      1     |
      Erosion                              |                         2                                                |      8  1.9|
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Hyperplasia, Diffuse         |                            2                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |             1              2                                             |      6  1.8|
      Basophilic Focus                     | X           X           X                                                |     24     |
      Clear Cell Focus                     |                         X                                                |      3     |
      Congestion                           |                3                                                         |      2  2.5|
      Degeneration, Cystic                 |    1                                                                     |      8  1.9|
      Granuloma                            |                                                                          |      6  1.2|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      6     |
      Hyperplasia, Focal                   |                   2                                                      |      4  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      4  1.3|
      Mixed Cell Focus                     |                            X                                             |      3     |
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    3  1     2  2  2  2  4  1                                             |     47  1.6|
      Centrilobular, Atrophy               |                3     2  2                                                |      7  2.4|
      Centrilobular, Necrosis              |                                                                          |      2  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                      2                                                   |     13  2.4|
      Kupffer Cell, Pigmentation           |                                                                          |      4  1.8|
      Lobules, Necrosis                    |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    1     1     1     1  2  1                                             |     33  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 112                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 6| 6| 6| 4| 4| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7|                                            |            |
                                           | 0| 0| 6| 1| 3| 8| 6| 9| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.25%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Focal Cellular Change                |                                                                          |      1     |
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
      Acinar Cell, Cytoplasmic Alteration  |             3              3                                             |     13  2.8|
      Acinar Cell, Hyperplasia, Focal      |                            1                                             |      7  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.0|
      Acinar Cell, Cytoplasmic Alteration  | 3                                                                        |      4  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                      3  3                                                |      4  3.0|
      Erosion                              |                1                                                         |      1  1.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Ulcer                                |                      4  3  4                                             |      9  3.7|
      Mucosa, Hyperplasia                  |                1     2  3  3                                             |     10  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                         3  3                                             |      5  2.4|
      Erosion                              |                                                                          |      6  2.2|
      Mineralization                       |          3                                                               |      2  3.0|
      Ulcer                                |                            2                                             |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2        1  3                                                            |     29  1.7|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Mineralization           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | X     X           X                                                      |     15     |
      Hyperplasia, Focal                   |                         3                                                |      7  1.9|
      Hypertrophy, Focal                   |                                                                          |      2  1.5|
      Pigmentation                         |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                      3                                                   |      4  2.3|
      Vacuolization Cytoplasmic, Focal     |          3     1        3  1                                             |     17  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 1        2     2        1  2                                             |     23  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                1                                                         |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 113                                                               
NTP Experiment-Test: 05142-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TERT-BUTYL ALCOHOL                                    Date: 04/23/97  
Route: DOSED WATER                                                                                                Time: 14:52:32  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 6| 6| 6| 4| 4| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7|                                            |            |
                                           | 0| 0| 6| 1| 3| 8| 6| 9| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.25%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |          3  2              3                                             |     13  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |             3  3  2                                                      |      3  2.7|
      Pars Distalis, Cyst                  |                            X                                             |      2     |
      Pars Distalis, Hyperplasia           |             2                                                            |      9  1.6|
      Pars Intermedia, Cyst                |