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TDMS Study 05143-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        CORN OIL / CORN OIL


NTP Experiment-Test: 05143-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 18:44:16




       Facility:  TSI Mason Research

       Chemical CAS #:  8001-30-7

       Lock Date:  11/08/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           14            9            6            4                        
    Natural Death                                      8            4            8            6            6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           32           33           38           40                        
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (48)         (50)         (50)         (50)                      
      Hyperkeratosis                                                             1 (2%)                                             
   Intestine Large, Colon                             (49)         (49)         (46)         (49)         (48)                      
      Cyst                                                                                                 1 (2%)                   
   Intestine Large, Cecum                             (46)         (49)         (45)         (48)         (46)                      
      Erosion                                          3 (7%)       1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Ileum                             (46)         (49)         (45)         (48)         (47)                      
      Erosion                                                       1 (2%)                                                          
      Fibrosis                                                                                1 (2%)                                
      Pigmentation                                                  1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                                   2 (4%)       1 (2%)                                             
      Basophilic Focus                                33 (66%)     33 (66%)     38 (76%)     37 (74%)     46 (92%)                  
      Clear Cell Focus                                11 (22%)     16 (32%)     27 (54%)     24 (48%)     21 (42%)                  
      Congestion                                       1 (2%)                                                                       
      Degeneration, Cystic                                                       2 (4%)                                             
      Eosinophilic Focus                               9 (18%)      3 (6%)       4 (8%)       4 (8%)       6 (12%)                  
      Fatty Change, Diffuse                            3 (6%)       2 (4%)      19 (38%)     27 (54%)     33 (66%)                  
      Fatty Change, Focal                              3 (6%)       4 (8%)                                 3 (6%)                   
      Hematocyst                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       4 (8%)       6 (12%)      4 (8%)       8 (16%)      5 (10%)                  
      Infarct                                          1 (2%)                                                                       
      Mixed Cell Focus                                 5 (10%)      5 (10%)      1 (2%)       8 (16%)      8 (16%)                  
      Necrosis                                         1 (2%)                                 1 (2%)                                
   Mesentery                                          (6)          (7)          (8)          (4)          (8)                       
      Fat, Hemorrhage                                                            1 (13%)                                            
      Fat, Inflammation, Chronic Active                1 (17%)      1 (14%)                                                         
      Fat, Mineralization                                                                                  2 (25%)                  
      Fat, Necrosis                                    2 (33%)      3 (43%)      5 (63%)      2 (50%)      7 (88%)                  
   Pancreas                                           (50)         (50)         (47)         (50)         (50)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Metaplasia                                                                                           1 (2%)                   
      Thrombosis                                                                 1 (2%)                                             
      Acinus, Atrophy                                 38 (76%)     40 (80%)     25 (53%)     32 (64%)     24 (48%)                  
      Acinus, Hyperplasia                              8 (16%)      5 (10%)     28 (60%)     28 (56%)     35 (70%)                  
      Acinus, Hypertrophy, Focal                                                                           1 (2%)                   
      Artery, Hyperplasia                                                        1 (2%)                                             
      Artery, Inflammation, Chronic Active             2 (4%)       2 (4%)       5 (11%)      1 (2%)       1 (2%)                   
   Pharynx                                            (1)                       (1)                                                 
      Hyperkeratosis                                   1 (100%)                                                                     
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Salivary Glands                                    (50)         (50)         (50)         (50)         (49)                      
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Duct, Metaplasia, Squamous                       6 (12%)      6 (12%)     11 (22%)      8 (16%)      8 (16%)                  
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
      Fibrosis                                                                   1 (2%)                                             
      Hyperkeratosis                                   3 (6%)       1 (2%)       1 (2%)       2 (4%)       5 (10%)                  
      Hyperplasia, Basal Cell                          4 (8%)       4 (8%)       2 (4%)       1 (2%)       8 (16%)                  
      Ulcer                                            2 (4%)                    3 (6%)       1 (2%)       3 (6%)                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (48)                      
      Erosion                                         10 (20%)      4 (8%)       2 (4%)       2 (4%)       2 (4%)                   
      Hyperplasia                                                   3 (6%)                                                          
      Mineralization                                                             1 (2%)                    1 (2%)                   
   Tongue                                                          (3)          (2)                       (3)                       
      Hemorrhage                                                                 2 (100%)                                           
      Hyperplasia, Squamous                                                                                1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Cardiomyopathy                                  47 (94%)     42 (84%)     46 (92%)     47 (94%)     45 (90%)                  
      Pigmentation                                                               1 (2%)                                             
      Thrombosis                                       3 (6%)       1 (2%)       1 (2%)                    1 (2%)                   
      Artery, Inflammation, Chronic Active                          1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Hypertrophy                                      2 (4%)       3 (6%)       4 (8%)                                             
   Adrenal Medulla                                    (49)         (49)         (50)         (50)         (50)                      
      Cyst                                                                                                 1 (2%)                   
      Hyperplasia                                      8 (16%)      7 (14%)     12 (24%)     11 (22%)      9 (18%)                  
   Islets, Pancreatic                                 (50)         (49)         (47)         (50)         (50)                      
      Hyperplasia                                      1 (2%)       2 (4%)       4 (9%)       2 (4%)       3 (6%)                   
   Parathyroid Gland                                  (44)         (47)         (49)         (40)         (45)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (3%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (49)         (50)                      
      Pars Distalis, Angiectasis                       5 (10%)      6 (12%)      5 (10%)      4 (8%)       6 (12%)                  
      Pars Distalis, Cyst                                           1 (2%)       3 (6%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)      9 (18%)     13 (26%)      9 (18%)      9 (18%)                  
      Pars Intermedia, Hyperplasia                                                                         1 (2%)                   
      Rathke's Cleft, Cyst                                          1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (49)         (49)         (49)                      
      Bilateral, C-Cell, Hyperplasia                                             1 (2%)       1 (2%)                                
      C-Cell, Hyperplasia                              3 (6%)       9 (18%)      8 (16%)      7 (14%)     11 (22%)                  
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                               3 (6%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)         (48)                      
      Spermatocele                                                  1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)         (48)                      
      Abscess                                          3 (6%)       4 (8%)       4 (8%)       5 (10%)      7 (15%)                  
      Hyperplasia, Squamous                                                      1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
   Prostate                                           (50)         (49)         (50)         (50)         (48)                      
      Hyperplasia                                      2 (4%)       4 (8%)       6 (12%)      7 (14%)      4 (8%)                   
      Inflammation, Acute                                                                                  1 (2%)                   
      Inflammation, Chronic Active                     2 (4%)       2 (4%)       3 (6%)                                             
   Testes                                             (50)         (50)         (50)         (50)         (49)                      
      Interstitial Cell, Hyperplasia                                4 (8%)       3 (6%)       4 (8%)       4 (8%)                   
      Seminiferous Tubule, Atrophy                     7 (14%)      4 (8%)       2 (4%)       4 (8%)       6 (12%)                  
      Seminiferous Tubule, Mineralization                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Depletion Cellular                               1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
   Lymph Node                                         (28)         (22)         (15)         (13)         (8)                       
      Lumbar, Pigmentation                                          1 (5%)                                                          
      Mediastinal, Angiectasis                         4 (14%)      1 (5%)       3 (20%)      5 (38%)      1 (13%)                  
      Mediastinal, Ectasia                             1 (4%)                                                                       
      Mediastinal, Infiltration Cellular, Mast Cell    1 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Pigmentation                                                  4 (27%)      1 (8%)       2 (25%)                  
      Pancreatic, Angiectasis                          1 (4%)                                 1 (8%)                                
      Pancreatic, Ectasia                              3 (11%)                   2 (13%)                                            
      Pancreatic, Infiltration Cellular, Histiocyte    2 (7%)                                              2 (25%)                  
      Pancreatic, Pigmentation                                                   1 (7%)                    1 (13%)                  
      Renal, Pigmentation                                           1 (5%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (49)         (50)         (48)                      
      Angiectasis                                                                                          1 (2%)                   
      Necrosis                                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)         (49)                      
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Ectasia                                          2 (4%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (49)         (50)         (49)         (50)         (49)                      
      Angiectasis                                      2 (4%)                                              1 (2%)                   
      Fibrosis                                        12 (24%)      8 (16%)      9 (18%)      3 (6%)       4 (8%)                   
      Hematopoietic Cell Proliferation                 8 (16%)      6 (12%)      3 (6%)       5 (10%)      5 (10%)                  
      Infarct                                          2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Lipocyte                                                                      1 (2%)                   
      Metaplasia                                                                                           1 (2%)                   
      Pigmentation                                                               2 (4%)       1 (2%)       1 (2%)                   
      Capsule, Fibrosis                                                          1 (2%)                                             
      Capsule, Hemorrhage                                                                     1 (2%)                                
   Thymus                                             (48)         (48)         (45)         (45)         (46)                      
      Cyst                                                          1 (2%)                                                          
      Epithelial Cell, Hyperplasia                    10 (21%)      7 (15%)      5 (11%)      5 (11%)      9 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (42)         (39)         (39)         (40)                      
      Galactocele                                                                                          2 (5%)                   
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Cyst Epithelial Inclusion                                                  4 (8%)       2 (4%)       2 (4%)                   
      Developmental Malformation                                                 1 (2%)                                             
      Erosion                                                       1 (2%)       1 (2%)                                             
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                                                                           1 (2%)                   
      Hyperkeratosis                                                                                       2 (4%)                   
      Inflammation, Acute                                                                                  1 (2%)                   
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Hyperostosis                                                               2 (4%)                                             
   Skeletal Muscle                                    (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                          5 (10%)      3 (6%)       8 (16%)      5 (10%)      2 (4%)                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)         (50)                      
      Compression                                      1 (2%)                    1 (2%)                                             
   Spinal Cord                                                                  (1)          (1)          (1)                       
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (49)         (49)                      
      Edema                                            1 (2%)                    1 (2%)       2 (4%)       1 (2%)                   
      Foreign Body                                                               1 (2%)                                             
      Fungus                                           1 (2%)                                                                       
      Hemorrhage                                                                 2 (4%)                    1 (2%)                   
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                2 (4%)       5 (10%)                   1 (2%)       2 (4%)                   
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)                                             
      Metaplasia, Osseous                                           1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)       1 (2%)       1 (2%)       2 (4%)                   
   Nose                                               (50)         (50)         (50)         (49)         (49)                      
      Fungus                                          13 (26%)     12 (24%)     12 (24%)     18 (37%)     15 (31%)                  
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                             16 (32%)     14 (28%)     17 (34%)     21 (43%)     21 (43%)                  
      Metaplasia, Cartilagenous                                                               1 (2%)                                
      Respiratory Epithelium, Hyperkeratosis                                     3 (6%)       1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     7 (14%)      8 (16%)      2 (4%)       7 (14%)      8 (16%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (2)          (3)          (2)                       
      Synechia                                                      1 (33%)                   1 (33%)      2 (100%)                 
      Lens, Cataract                                                2 (67%)                   2 (67%)                               
      Retina, Atrophy                                  1 (100%)     1 (33%)                   1 (33%)      2 (100%)                 
      Sclera, Mineralization                                                     1 (50%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (48)         (50)         (49)                      
      Degeneration                                     1 (2%)                                                                       
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Nephropathy                                     47 (94%)     45 (92%)     43 (90%)     45 (90%)     40 (82%)                  
      Cortex, Mineralization                                        1 (2%)                                 2 (4%)                   
      Cortex, Necrosis                                              1 (2%)                                                          
      Papilla, Mineralization                                                                              2 (4%)                   
      Renal Tubule, Pigmentation                                                                           1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
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