National Toxicology Program

National Toxicology Program
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TDMS Study 05143-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        CORN OIL / CORN OIL


NTP Experiment-Test: 05143-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 18:44:17




       Facility:  TSI Mason Research

       Chemical CAS #:  8001-30-7

       Lock Date:  11/08/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05143-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           14            9            6            4                        
    Natural Death                                      8            4            8            6            6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           32           33           38           40                        
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (49)         (46)         (49)         (48)                      
   Intestine Large, Cecum                             (46)         (49)         (45)         (48)         (46)                      
   Intestine Small, Duodenum                          (48)         (49)         (47)         (50)         (48)                      
   Intestine Small, Jejunum                           (44)         (49)         (45)         (48)         (47)                      
      Muscularis, Leiomyosarcoma                                                                           1 (2%)                   
   Intestine Small, Ileum                             (46)         (49)         (45)         (48)         (47)                      
      Adenocarcinoma                                                             1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Hepatocellular Adenoma                           4 (8%)                    2 (4%)                                             
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Mesentery                                          (6)          (7)          (8)          (4)          (8)                       
   Pancreas                                           (50)         (50)         (47)         (50)         (50)                      
      Mixed Tumor Benign                                            1 (2%)                                                          
      Acinus, Adenoma                                  1 (2%)       1 (2%)       6 (13%)      3 (6%)      11 (22%)                  
      Acinus, Adenoma, Multiple                                                  2 (4%)       7 (14%)     12 (24%)                  
      Acinus, Carcinoma                                                                       1 (2%)                                
   Pharynx                                            (1)                       (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (50)         (50)         (50)         (50)         (49)                      
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (48)                      
      Leiomyosarcoma                                                                          1 (2%)                                
   Tongue                                                          (3)          (2)                       (3)                       
      Squamous Cell Papilloma                                                                              1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05143-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
   Adrenal Medulla                                    (49)         (49)         (50)         (50)         (50)                      
      Ganglioneuroma                                                             1 (2%)                                             
      Pheochromocytoma Malignant                       2 (4%)       1 (2%)       1 (2%)       1 (2%)       2 (4%)                   
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                         18 (37%)     13 (27%)     15 (30%)      3 (6%)       7 (14%)                  
      Bilateral, Pheochromocytoma Malignant            1 (2%)                                                                       
      Bilateral, Pheochromocytoma Benign               2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (47)         (50)         (50)                      
      Adenoma                                          9 (18%)      5 (10%)      3 (6%)       4 (8%)       7 (14%)                  
   Parathyroid Gland                                  (44)         (47)         (49)         (40)         (45)                      
   Pituitary Gland                                    (50)         (49)         (50)         (49)         (50)                      
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (2%)                   
      Pars Distalis, Adenoma                           5 (10%)      6 (12%)     10 (20%)      6 (12%)      7 (14%)                  
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (49)         (49)         (49)                      
      Bilateral, C-Cell, Adenoma                                                              1 (2%)       2 (4%)                   
      C-Cell, Adenoma                                  4 (8%)       3 (6%)       5 (10%)      3 (6%)       8 (16%)                  
      C-Cell, Carcinoma                                1 (2%)                    1 (2%)                    1 (2%)                   
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                                                                           1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                                              (1)                                                 
   Epididymis                                         (50)         (50)         (50)         (50)         (48)                      
   Preputial Gland                                    (50)         (50)         (50)         (50)         (48)                      
      Adenoma                                          6 (12%)      8 (16%)      2 (4%)       3 (6%)       3 (6%)                   
      Bilateral, Adenoma                                                         1 (2%)       1 (2%)                                
   Prostate                                           (50)         (49)         (50)         (50)         (48)                      
      Adenoma                                                                                              2 (4%)                   
   Seminal Vesicle                                    (50)         (49)         (49)         (50)         (48)                      
   Testes                                             (50)         (50)         (50)         (50)         (49)                      
      Bilateral, Interstitial Cell, Adenoma           40 (80%)     39 (78%)     43 (86%)     41 (82%)     39 (80%)                  
                                                             Page   3                                                               
NTP Experiment-Test: 05143-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Interstitial Cell, Adenoma                       8 (16%)      8 (16%)      3 (6%)       6 (12%)      9 (18%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (8)          (9)          (4)          (3)                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
   Lymph Node                                         (28)         (22)         (15)         (13)         (8)                       
   Lymph Node, Mandibular                             (50)         (50)         (49)         (50)         (48)                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)         (49)                      
   Spleen                                             (49)         (50)         (49)         (50)         (49)                      
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Thymus                                             (48)         (48)         (45)         (45)         (46)                      
      Epithelial Cell, Thymoma Benign                  1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (42)         (39)         (39)         (40)                      
      Fibroadenoma                                     4 (13%)      2 (5%)       1 (3%)       1 (3%)       3 (8%)                   
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Adenoma                                                                                   1 (2%)                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  1 (2%)                    1 (2%)                    1 (2%)                   
      Squamous Cell Carcinoma                          2 (4%)       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)       5 (10%)      1 (2%)                   
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (6%)       1 (2%)       1 (2%)       5 (10%)                  
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (50)         (50)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)         (50)                      
   Spinal Cord                                                                  (1)          (1)          (1)                       
      Astrocytoma Malignant                                                                                1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05143-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (49)         (49)                      
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                    1 (2%)       3 (6%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (2%)                   
      Fibrosarcoma, Metastatic, Ear                                 1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Mediastinum, Carcinoma, Metastatic, Zymbal's                                                                                  
          Gland                                                                                            1 (2%)                   
   Nose                                               (50)         (50)         (50)         (49)         (49)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (2)          (1)          (2)                                    
      Fibrosarcoma                                                  1 (50%)                                                         
      Fibrous Histiocytoma                                          1 (50%)                                                         
   Harderian Gland                                                                           (1)                                    
      Carcinoma                                                                               1 (100%)                              
   Zymbal's Gland                                                  (2)                                    (1)                       
      Adenoma                                                       1 (50%)                                                         
      Carcinoma                                                     1 (50%)                                1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (48)         (50)         (49)                      
   Urinary Bladder                                    (49)         (49)         (47)         (50)         (48)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Leukemia Granulocytic                                                                                1 (2%)                   
      Leukemia Mononuclear                            27 (54%)     30 (60%)     16 (32%)     11 (22%)      7 (14%)                  
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                           2 (4%)       1 (2%)       1 (2%)       1 (2%)       3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05143-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          48          49          48          50                           
     Total Primary Neoplasms                          144         133         128         106         141                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          48          49          48          50                           
     Total Benign Neoplasms                           107          96         105          89         122                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          31          21          16          16                           
     Total Malignant Neoplasms                         37          37          23          17          19                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           3           1           3                           
     Total Metastatic Neoplasm                          8           4           7          13          12                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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