National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2178

TDMS Study 05144-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           SAFFLOWER OIL


NTP Experiment-Test: 05144-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 19:47:02




       Facility:  TSI Mason Research

       Chemical CAS #:  8001-23-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Natural Death                                      8            8            3           10                                     
    Moribund Sacrifice                                12            9            7            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           33           40           36                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (56)         (59)         (58)         (58)                                   
      Ulcer                                            1 (2%)                                                                       
   Intestine Large, Rectum                            (57)         (57)         (57)         (56)                                   
      Submucosa, Edema                                                                        1 (2%)                                
   Intestine Small, Duodenum                          (58)         (60)         (58)         (58)                                   
      Mucosa, Hyperplasia, Diffuse                     1 (2%)                                                                       
   Intestine Small, Jejunum                           (55)         (58)         (57)         (55)                                   
      Mucosa, Hyperplasia, Diffuse                     1 (2%)                                                                       
   Intestine Small, Ileum                             (55)         (59)         (58)         (56)                                   
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                36 (60%)     34 (57%)     41 (68%)     42 (70%)                               
      Clear Cell Focus                                23 (38%)     22 (37%)     25 (42%)     35 (58%)                               
      Cyst                                             2 (3%)                                                                       
      Eosinophilic Focus                               5 (8%)       2 (3%)       4 (7%)       2 (3%)                                
      Fatty Change, Diffuse                                                      1 (2%)       6 (10%)                               
      Fatty Change, Focal                              7 (12%)      4 (7%)       7 (12%)     10 (17%)                               
      Hepatodiaphragmatic Nodule                       4 (7%)       3 (5%)       2 (3%)       2 (3%)                                
      Hepatodiaphragmatic Nodule, Multiple                          1 (2%)                                                          
      Hyperplasia                                      4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)       2 (3%)       2 (3%)       6 (10%)                               
      Necrosis                                         4 (7%)       4 (7%)       4 (7%)       4 (7%)                                
      Pigmentation                                                  1 (2%)                                                          
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Thrombosis                                       3 (5%)                                                                       
      Centrilobular, Degeneration                                   1 (2%)                                                          
   Mesentery                                          (10)         (8)          (11)         (7)                                    
      Abscess                                                                    1 (9%)                                             
      Inflammation, Chronic Active                                  1 (13%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic Active                                       1 (9%)                                             
      Fat, Hemorrhage                                               1 (13%)                                                         
      Fat, Inflammation, Chronic Active                2 (20%)                                1 (14%)                               
      Fat, Mineralization                              1 (10%)      1 (13%)                                                         
      Fat, Necrosis                                    8 (80%)      5 (63%)      9 (82%)      6 (86%)                               
   Pancreas                                           (60)         (60)         (59)         (59)                                   
      Acinus, Atrophy                                 48 (80%)     45 (75%)     41 (69%)     43 (73%)                               
      Acinus, Fibrosis                                 1 (2%)                                                                       
      Acinus, Hyperplasia                             10 (17%)     15 (25%)     33 (56%)     37 (63%)                               
      Artery, Inflammation, Chronic Active             1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
      Vein, Angiectasis                                1 (2%)                                                                       
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
      Hyperplasia                                                   2 (3%)                                                          
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Duct, Metaplasia                                 1 (2%)                                                                       
      Duct, Metaplasia, Squamous                      14 (23%)     11 (19%)     10 (17%)     13 (22%)                               
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Hyperkeratosis                                  11 (18%)     17 (28%)     20 (33%)     24 (40%)                               
      Hyperplasia, Basal Cell                         21 (35%)     17 (28%)     26 (43%)     29 (48%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                            3 (5%)       2 (3%)       2 (3%)       4 (7%)                                
   Stomach, Glandular                                 (59)         (60)         (59)         (59)                                   
      Erosion                                          8 (14%)      6 (10%)      1 (2%)       2 (3%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Mucosa, Hyperplasia, Diffuse                                  1 (2%)                                                          
   Tongue                                             (1)                                    (1)                                    
      Hyperkeratosis                                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  56 (93%)     56 (93%)     49 (82%)     51 (85%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                       2 (3%)       3 (5%)                    1 (2%)                                
      Atrium, Dilatation                                            1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (58)                                   
      Hyperplasia                                      1 (2%)       1 (2%)       4 (7%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
   Adrenal Medulla                                    (59)         (58)         (59)         (58)                                   
      Hyperplasia                                     23 (39%)     24 (41%)     16 (27%)     19 (33%)                               
   Islets, Pancreatic                                 (59)         (60)         (59)         (58)                                   
      Hyperplasia                                      5 (8%)       4 (7%)       4 (7%)       5 (9%)                                
   Parathyroid Gland                                  (55)         (50)         (50)         (51)                                   
      Hyperplasia                                      2 (4%)                                 1 (2%)                                
   Pituitary Gland                                    (60)         (58)         (59)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Pars Distalis, Angiectasis                       4 (7%)       6 (10%)      3 (5%)       5 (8%)                                
      Pars Distalis, Cyst                              2 (3%)       8 (14%)      1 (2%)       2 (3%)                                
      Pars Distalis, Hyperplasia                       9 (15%)     16 (28%)     11 (19%)     10 (17%)                               
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Nervosa, Cyst                               1 (2%)                                                                       
   Thyroid Gland                                      (58)         (59)         (58)         (58)                                   
      C-Cell, Hyperplasia                             10 (17%)      6 (10%)      9 (16%)     19 (33%)                               
      Follicle, Cyst                                   1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (1)                                                 
      Abdominal, Ectopic Tissue                                     1 (100%)                                                        
      Oral, Hyperplasia, Squamous                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (60)         (60)         (59)         (58)                                   
      Abscess                                          5 (8%)       6 (10%)      4 (7%)       5 (9%)                                
      Cyst                                             3 (5%)       2 (3%)       1 (2%)       1 (2%)                                
      Dilatation                                       8 (13%)                   2 (3%)                                             
      Dilatation, Multiple                             1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
   Prostate                                           (59)         (59)         (58)         (58)                                   
      Hyperplasia                                      1 (2%)       5 (8%)       2 (3%)       3 (5%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Metaplasia, Squamous                             2 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Interstitium, Edema                              1 (2%)                                                                       
   Seminal Vesicle                                    (60)         (59)         (60)         (59)                                   
      Depletion Cellular                              18 (30%)                                                                      
   Testes                                             (60)         (60)         (59)         (60)                                   
      Interstitial Cell, Hyperplasia                   8 (13%)     11 (18%)      6 (10%)     11 (18%)                               
      Seminiferous Tubule, Atrophy                     3 (5%)       3 (5%)       1 (2%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (25)         (19)         (18)         (8)                                    
      Inguinal, Infiltration Cellular, Plasma Cell                               1 (6%)                                             
      Mediastinal, Angiectasis                         2 (8%)       1 (5%)       3 (17%)      3 (38%)                               
      Mediastinal, Ectasia                                          1 (5%)                                                          
      Mediastinal, Hematopoietic Cell Proliferation    1 (4%)                                                                       
      Mediastinal, Hemorrhage                          1 (4%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         1 (6%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                   1 (6%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Polymorphonuclear                                                      1 (6%)                                             
      Mediastinal, Inflammation, Acute                              1 (5%)                                                          
      Mediastinal, Pigmentation                        2 (8%)       5 (26%)                                                         
      Mediastinal, Lymphatic, Ectasia                  1 (4%)                                                                       
      Pancreatic, Angiectasis                                       1 (5%)                    1 (13%)                               
      Pancreatic, Hyperplasia, Lymphoid                3 (12%)      1 (5%)       3 (17%)                                            
      Pancreatic, Infiltration Cellular, Histiocyte    1 (4%)       1 (5%)                                                          
      Pancreatic, Pigmentation                         1 (4%)                                                                       
      Renal, Angiectasis                               1 (4%)                                                                       
      Renal, Infiltration Cellular, Histiocyte         1 (4%)                                                                       
   Lymph Node, Mandibular                             (60)         (56)         (57)         (59)                                   
      Angiectasis                                                   4 (7%)                                                          
      Congestion                                                                              1 (2%)                                
      Ectasia                                                       2 (4%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
      Infiltration Cellular, Plasma Cell               3 (5%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Pigmentation                                                  2 (4%)                                                          
      Lymphatic, Ectasia                                            1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (60)         (59)         (58)                                   
      Angiectasis                                      1 (2%)       3 (5%)       2 (3%)                                             
      Congestion                                                                              1 (2%)                                
      Ectasia                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Spleen                                             (60)         (60)         (58)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Angiectasis                                                   1 (2%)                                                          
      Atrophy                                          1 (2%)                                                                       
      Depletion Lymphoid                               2 (3%)                    1 (2%)       1 (2%)                                
      Developmental Malformation                                                              1 (2%)                                
      Fibrosis                                        14 (23%)      4 (7%)                                                          
      Hematocyst                                                                              1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       8 (13%)      6 (10%)      6 (10%)                               
      Infarct                                          3 (5%)                    3 (5%)                                             
      Pigmentation                                     1 (2%)      13 (22%)                   2 (3%)                                
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Lymphoid Follicle, Atrophy                                                              1 (2%)                                
   Thymus                                             (50)         (51)         (51)         (52)                                   
      Depletion Lymphoid                               1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Epithelial Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (52)         (53)         (51)                                   
      Galactocele                                                   2 (4%)                    1 (2%)                                
   Skin                                               (58)         (59)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        2 (3%)       2 (3%)                                                          
      Erosion                                                                    1 (2%)                                             
      Hyperkeratosis                                   1 (2%)                                 1 (2%)                                
      Hyperplasia, Basal Cell                          1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Foot, Acanthosis                                                                        1 (2%)                                
      Foot, Inflammation, Chronic Active                                                      1 (2%)                                
      Subcutaneous Tissue, Granuloma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (50)         (50)         (51)                                   
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Inflammation, Acute                                                                     1 (2%)                                
      Abdominal, Fibrosis                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                 1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Congestion                                       2 (3%)       2 (3%)       2 (3%)       2 (3%)                                
      Edema                                                         1 (2%)                    1 (2%)                                
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Hemorrhage                                       2 (3%)       1 (2%)       2 (3%)                                             
      Hemorrhage, Focal                                             1 (2%)                                                          
      Infiltration Cellular, Histiocyte                4 (7%)      11 (18%)      5 (8%)                                             
      Inflammation, Acute                              1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (7%)       2 (3%)       3 (5%)       3 (5%)                                
      Alveolus, Foreign Body                                        1 (2%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       1 (2%)                                                          
      Alveolus, Inflammation, Acute                    1 (2%)                                                                       
      Alveolus, Pigmentation, Focal                    1 (2%)                                                                       
      Bronchiole, Metaplasia, Squamous                                           1 (2%)                                             
      Interstitium, Inflammation, Chronic Active                    1 (2%)                                                          
      Mediastinum, Abscess                                                                    1 (2%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Foreign Body                                     7 (12%)     50 (83%)     48 (80%)     51 (85%)                               
      Fungus                                          24 (40%)     46 (77%)     41 (68%)     41 (68%)                               
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Acute                             26 (43%)     59 (98%)     60 (100%)    59 (98%)                               
      Metaplasia, Squamous                             1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Respiratory Epithelium, Hyperplasia             13 (22%)     48 (80%)     56 (93%)     53 (88%)                               
      Respiratory Epithelium, Metaplasia, Squamous    16 (27%)     39 (65%)     34 (57%)     29 (48%)                               
      Vein, Thrombosis                                 1 (2%)                                                                       
   Trachea                                            (59)         (60)         (60)         (59)                                   
      Lumen, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (1)          (1)                                    
      Inflammation, Chronic Active                                               1 (100%)     1 (100%)                              
   Eye                                                (2)                                    (2)                                    
      Inflammation, Chronic Active                                                            1 (50%)                               
      Cornea, Necrosis                                 1 (50%)                                                                      
      Lens, Cataract                                   1 (50%)                                1 (50%)                               
      Retina, Atrophy                                                                         1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05144-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (58)                                   
      Cyst                                             2 (3%)                    3 (5%)                                             
      Degeneration, Hyaline                                         1 (2%)                                                          
      Glomerulosclerosis                               1 (2%)                                                                       
      Nephropathy                                     59 (98%)     56 (93%)     50 (83%)     55 (95%)                               
      Pigmentation                                     5 (8%)                                                                       
      Renal Tubule, Degeneration                       1 (2%)                                                                       
   Urinary Bladder                                    (58)         (59)         (59)         (57)                                   
      Calculus Gross Observation                                    4 (7%)       3 (5%)       3 (5%)                                
      Calculus Micro Observation Only                               4 (7%)       2 (3%)       3 (5%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.