National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2182

TDMS Study 05144-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           SAFFLOWER OIL


NTP Experiment-Test: 05144-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 19:47:02




       Facility:  TSI Mason Research

       Chemical CAS #:  8001-23-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05144-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Natural Death                                      8            8            3           10                                     
    Moribund Sacrifice                                12            9            7            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           33           40           36                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (58)         (58)         (58)                                   
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Intestine Large, Colon                             (56)         (59)         (58)         (58)                                   
      Sarcoma                                                                    1 (2%)                                             
   Intestine Large, Rectum                            (57)         (57)         (57)         (56)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Intestine Large, Cecum                             (55)         (58)         (57)         (57)                                   
   Intestine Small, Duodenum                          (58)         (60)         (58)         (58)                                   
   Intestine Small, Jejunum                           (55)         (58)         (57)         (55)                                   
   Intestine Small, Ileum                             (55)         (59)         (58)         (56)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                    1 (2%)                                             
      Hepatocellular Adenoma                           2 (3%)       2 (3%)       1 (2%)                                             
   Mesentery                                          (10)         (8)          (11)         (7)                                    
   Pancreas                                           (60)         (60)         (59)         (59)                                   
      Acinus, Adenoma                                  1 (2%)       5 (8%)       9 (15%)     10 (17%)                               
      Acinus, Adenoma, Multiple                                     2 (3%)       6 (10%)     19 (32%)                               
      Acinus, Carcinoma                                                                       1 (2%)                                
      Acinus, Carcinoma, Multiple                                                             1 (2%)                                
      Acinus, Mixed Tumor Benign                                                 1 (2%)                                             
   Pharynx                                                         (1)                                                              
      Palate, Squamous Cell Carcinoma                               1 (100%)                                                        
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)                    2 (3%)       1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (59)         (59)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05144-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Carcinoma                                                                               1 (2%)                                
   Tongue                                             (1)                                    (1)                                    
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Tooth                                              (1)                                                                           
      Odontoma                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (58)                                   
      Adenoma                                                                                 2 (3%)                                
   Adrenal Medulla                                    (59)         (58)         (59)         (58)                                   
      Ganglioneuroma                                                             1 (2%)                                             
      Pheochromocytoma Malignant                       2 (3%)                                 1 (2%)                                
      Pheochromocytoma Benign                         14 (24%)     10 (17%)      8 (14%)      7 (12%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)       2 (3%)       3 (5%)       1 (2%)                                
   Islets, Pancreatic                                 (59)         (60)         (59)         (58)                                   
      Adenoma                                          6 (10%)      2 (3%)       5 (8%)       3 (5%)                                
      Adenoma, Multiple                                1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (60)         (58)         (59)         (59)                                   
      Pars Distalis, Adenoma                           8 (13%)     10 (17%)      4 (7%)       8 (14%)                               
   Thyroid Gland                                      (58)         (59)         (58)         (58)                                   
      C-Cell, Adenoma                                  5 (9%)       4 (7%)       8 (14%)      4 (7%)                                
      Follicular Cell, Adenoma                         2 (3%)       2 (3%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (60)                                   
   Preputial Gland                                    (60)         (60)         (59)         (58)                                   
      Adenoma                                          8 (13%)      6 (10%)      4 (7%)       2 (3%)                                
      Bilateral, Adenoma                                            1 (2%)                    1 (2%)                                
   Prostate                                           (59)         (59)         (58)         (58)                                   
   Seminal Vesicle                                    (60)         (59)         (60)         (59)                                   
   Testes                                             (60)         (60)         (59)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           50 (83%)     46 (77%)     50 (85%)     47 (78%)                               
      Interstitial Cell, Adenoma                       7 (12%)      9 (15%)      6 (10%)      8 (13%)                               
                                                             Page   3                                                               
NTP Experiment-Test: 05144-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (15)         (11)         (7)          (2)                                    
   Bone Marrow                                        (59)         (59)         (60)         (59)                                   
   Lymph Node                                         (25)         (19)         (18)         (8)                                    
   Lymph Node, Mandibular                             (60)         (56)         (57)         (59)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (60)         (59)         (58)                                   
   Spleen                                             (60)         (60)         (58)         (60)                                   
   Thymus                                             (50)         (51)         (51)         (52)                                   
      Schwannoma Malignant, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Thymoma Benign                                   1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (52)         (53)         (51)                                   
      Fibroadenoma                                     6 (12%)      2 (4%)       1 (2%)       2 (4%)                                
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (58)         (59)         (60)         (60)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Keratoacanthoma                                               1 (2%)       3 (5%)       1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)       1 (2%)       1 (2%)                                
      Squamous Cell Papilloma                          2 (3%)       2 (3%)       4 (7%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (5%)       2 (3%)       2 (3%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             2 (3%)                    1 (2%)                                
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (50)         (50)         (50)         (51)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Rhabdomyosarcoma                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05144-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                         1 (2%)                                                          
      Glioma Malignant                                                           1 (2%)                                             
      Oligodendroglioma Malignant                                                1 (2%)                                             
   Spinal Cord                                        (1)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                 1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Heart                                                 1 (2%)                                
      Mediastinum, Schwannoma Malignant                             1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Nasopharyngeal Duct, Squamous Cell Carcinoma     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                           (1)                                    
      Carcinoma                                                                               1 (100%)                              
   Zymbal's Gland                                                  (2)                                                              
      Carcinoma                                                     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (58)                                   
      Sarcoma                                          1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (58)         (59)         (59)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            35 (58%)     19 (32%)     18 (30%)      7 (12%)                               
      Mesothelioma Malignant                                        2 (3%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05144-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SAFFLOWER OIL                                       Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 19:47:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          58          58          59                                       
     Total Primary Neoplasms                          163         144         142         139                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 58          57          56          58                                       
     Total Benign Neoplasms                           123         112         118         123                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          29          23          15                                       
     Total Malignant Neoplasms                         40          32          24          16                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4                       6                                       
     Total Metastatic Neoplasm                          2           7                       7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.