National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2190

TDMS Study 05145-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            TRICAPRYLIN


NTP Experiment-Test: 05145-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 20:47:57




       Facility:  TSI Mason Research

       Chemical CAS #:  538-23-8

       Lock Date:  12/26/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            7                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           13           15           17                                     
    Natural Death                                      4            7            4           13                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                                           1                                                  
    Terminal Sacrifice                                29           30           30           22                                     
    Natural Death                                      2                                      1                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)         (56)         (58)         (51)                                   
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Duodenum                          (59)         (56)         (58)         (49)                                   
      Hyperplasia, Adenomatous                         1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Ileum                             (56)         (56)         (58)         (49)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (58)                                   
      Basophilic Focus                                35 (58%)     39 (65%)     34 (57%)     31 (53%)                               
      Clear Cell Focus                                10 (17%)     20 (33%)     22 (37%)     13 (22%)                               
      Congestion                                                    1 (2%)       2 (3%)                                             
      Cyst                                                                                    1 (2%)                                
      Cyst Multilocular                                                          1 (2%)                                             
      Eosinophilic Focus                               7 (12%)      4 (7%)       6 (10%)      3 (5%)                                
      Fatty Change, Diffuse                            1 (2%)                    2 (3%)                                             
      Fatty Change, Focal                              4 (7%)       2 (3%)                    3 (5%)                                
      Fibrosis                                                                   1 (2%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (5%)       5 (8%)       7 (12%)      6 (10%)                               
      Hyperplasia                                      1 (2%)       5 (8%)       2 (3%)                                             
      Hypertrophy                                                                             1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Mixed Cell Focus                                 7 (12%)      7 (12%)      7 (12%)      4 (7%)                                
      Necrosis                                         3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
      Necrosis, Focal                                               1 (2%)                                                          
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Centrilobular, Degeneration                                   1 (2%)                                                          
   Mesentery                                          (9)          (14)         (4)          (6)                                    
      Thrombosis                                                    1 (7%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic Active                          1 (7%)                                                          
      Fat, Hemorrhage                                               1 (7%)                                                          
      Fat, Inflammation, Chronic Active                1 (11%)                                1 (17%)                               
      Fat, Mineralization                              1 (11%)      2 (14%)                                                         
      Fat, Necrosis                                    3 (33%)      8 (57%)      1 (25%)      4 (67%)                               
   Pancreas                                           (59)         (59)         (59)         (57)                                   
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                                              1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Thrombosis                                                                 2 (3%)                                             
      Acinus, Atrophy                                 37 (63%)     41 (69%)     38 (64%)     29 (51%)                               
      Acinus, Basophilic Focus                         1 (2%)                    1 (2%)                                             
      Acinus, Hyperplasia                             11 (19%)     11 (19%)     24 (41%)     35 (61%)                               
      Artery, Hyperplasia                              2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Artery, Inflammation, Chronic Active             2 (3%)       4 (7%)       4 (7%)       2 (4%)                                
      Artery, Mineralization                                                                  1 (2%)                                
   Pharynx                                            (1)          (1)                                                              
      Thrombosis                                       1 (100%)                                                                     
   Salivary Glands                                    (60)         (59)         (58)         (58)                                   
      Cyst                                                                                    1 (2%)                                
      Duct, Metaplasia, Squamous                      10 (17%)     14 (24%)      4 (7%)       8 (14%)                               
   Stomach, Forestomach                               (60)         (60)         (59)         (59)                                   
      Erosion                                                                    1 (2%)                                             
      Hyperkeratosis                                   1 (2%)                    1 (2%)       5 (8%)                                
      Hyperplasia, Basal Cell                          2 (3%)       5 (8%)      10 (17%)     20 (34%)                               
      Hyperplasia, Basal Cell, Diffuse                              1 (2%)                    1 (2%)                                
      Hyperplasia, Basal Cell, Focal                   2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
      Hyperplasia, Diffuse, Squamous                                                          1 (2%)                                
      Inflammation, Acute                                                                     3 (5%)                                
      Mineralization, Focal                                                                   1 (2%)                                
      Ulcer                                            4 (7%)       1 (2%)                    2 (3%)                                
   Stomach, Glandular                                 (60)         (58)         (59)         (57)                                   
      Erosion                                          6 (10%)      3 (5%)       7 (12%)      5 (9%)                                
      Hyperplasia, Lymphoid                                                      5 (8%)                                             
      Inflammation, Chronic Active                     2 (3%)       1 (2%)                                                          
      Mineralization                                   1 (2%)                    6 (10%)      2 (4%)                                
   Tongue                                             (2)                       (1)                                                 
      Hemorrhage, Focal                                                          1 (100%)                                           
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (59)         (58)                                   
      Cardiomyopathy                                  53 (88%)     53 (88%)     54 (92%)     49 (84%)                               
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Thrombosis                                       5 (8%)       7 (12%)      4 (7%)       2 (3%)                                
      Atrium, Dilatation                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (59)         (58)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hypertrophy                                                                1 (2%)       1 (2%)                                
      Hypoplasia                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse                                                      1 (2%)                                
   Adrenal Medulla                                    (60)         (59)         (59)         (58)                                   
      Hyperplasia                                     22 (37%)     20 (34%)     22 (37%)     18 (31%)                               
   Islets, Pancreatic                                 (59)         (58)         (59)         (56)                                   
      Hyperplasia                                      7 (12%)      5 (9%)       3 (5%)       1 (2%)                                
   Parathyroid Gland                                  (50)         (56)         (57)         (53)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (60)         (57)         (59)         (58)                                   
      Pars Distalis, Angiectasis                       3 (5%)       1 (2%)       3 (5%)       2 (3%)                                
      Pars Distalis, Congestion                                     1 (2%)                                                          
      Pars Distalis, Cyst                              2 (3%)       2 (4%)       2 (3%)       4 (7%)                                
      Pars Distalis, Hyperplasia                      11 (18%)     11 (19%)     10 (17%)      6 (10%)                               
      Pars Distalis, Vacuolization Cytoplasmic                                   1 (2%)                                             
      Pars Intermedia, Cyst                                         1 (2%)       1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (57)         (56)         (59)         (54)                                   
      Fibrosis                                                      1 (2%)                                                          
      C-Cell, Hyperplasia                              7 (12%)      6 (11%)      9 (15%)      3 (6%)                                
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (59)         (58)         (60)         (58)                                   
      Abscess                                          3 (5%)       4 (7%)       6 (10%)      3 (5%)                                
      Cyst                                                                                    1 (2%)                                
      Dilatation                                                    2 (3%)       1 (2%)       2 (3%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                     2 (3%)                    1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Prostate                                           (59)         (59)         (59)         (59)                                   
      Hyperplasia                                      3 (5%)       9 (15%)      6 (10%)      7 (12%)                               
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
   Seminal Vesicle                                    (59)         (60)         (60)         (59)                                   
      Concretion                                                    1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
   Testes                                             (59)         (60)         (60)         (59)                                   
      Interstitial Cell, Hyperplasia                   6 (10%)      8 (13%)      7 (12%)     10 (17%)                               
      Seminiferous Tubule, Atrophy                     6 (10%)      6 (10%)      1 (2%)       3 (5%)                                
      Seminiferous Tubule, Giant Cell                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (25)         (25)         (25)         (16)                                   
      Lymphatic, Ectasia                                            1 (4%)                                                          
      Mediastinal, Angiectasis                         3 (12%)      2 (8%)       3 (12%)      9 (56%)                               
      Mediastinal, Congestion                                       1 (4%)                                                          
      Mediastinal, Ectasia                                                       5 (20%)                                            
      Mediastinal, Hyperplasia                                      1 (4%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (4%)                                                          
      Mediastinal, Infiltration Cellular, Mast Cell    1 (4%)                    2 (8%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                2 (8%)                                                          
      Mediastinal, Pigmentation                        3 (12%)      2 (8%)       3 (12%)      1 (6%)                                
      Mediastinal, Lymphatic, Ectasia                               1 (4%)                                                          
      Pancreatic, Angiectasis                                                    1 (4%)       1 (6%)                                
      Pancreatic, Ectasia                                           1 (4%)       1 (4%)       1 (6%)                                
      Pancreatic, Hyperplasia, Lymphoid                2 (8%)       2 (8%)                    1 (6%)                                
      Pancreatic, Infiltration Cellular, Histiocyte    1 (4%)                                                                       
      Pancreatic, Pigmentation                                                   1 (4%)                                             
      Pancreatic, Lymphatic, Ectasia                   1 (4%)       2 (8%)                                                          
      Renal, Pigmentation                                                        1 (4%)                                             
   Lymph Node, Mandibular                             (59)         (56)         (59)         (57)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Ectasia                                          1 (2%)                    2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                                      2 (3%)                                             
      Infiltration Cellular, Plasma Cell                            2 (4%)                                                          
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (58)         (59)         (60)         (55)                                   
      Angiectasis                                      2 (3%)                    1 (2%)       2 (4%)                                
      Ectasia                                          4 (7%)       2 (3%)       2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      2 (3%)                                             
      Infiltration Cellular, Histiocyte                             3 (5%)                                                          
      Lymphatic, Ectasia                                            1 (2%)                    1 (2%)                                
   Spleen                                             (59)         (60)         (59)         (58)                                   
      Angiectasis                                                   1 (2%)                                                          
      Depletion Lymphoid                                            1 (2%)       1 (2%)       3 (5%)                                
      Developmental Malformation                       1 (2%)       1 (2%)                    1 (2%)                                
      Fibrosis                                         8 (14%)     13 (22%)     16 (27%)      9 (16%)                               
      Hematopoietic Cell Proliferation                11 (19%)      9 (15%)     11 (19%)      7 (12%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          2 (3%)                    1 (2%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Pigmentation                                                                            3 (5%)                                
      Capsule, Fibrosis                                                                       1 (2%)                                
      Lymphoid Follicle, Atrophy                       2 (3%)                                                                       
   Thymus                                             (56)         (55)         (56)         (53)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (48)         (47)         (47)                                   
      Galactocele                                                                             2 (4%)                                
      Hemorrhage, Focal                                1 (2%)                                                                       
   Skin                                               (59)         (59)         (58)         (59)                                   
      Cyst                                                                                    1 (2%)                                
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)       1 (2%)                                             
      Developmental Malformation                                    1 (2%)                                                          
      Hyperkeratosis                                   2 (3%)                                 2 (3%)                                
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                     1 (2%)                    1 (2%)                                             
   Skeletal Muscle                                    (50)         (50)         (47)         (53)                                   
      Atrophy                                          3 (6%)       1 (2%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (59)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (58)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Edema                                                                      2 (3%)       2 (3%)                                
      Fungus                                           1 (2%)                                                                       
      Hemorrhage                                       2 (3%)       2 (3%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)       6 (10%)      4 (7%)       4 (7%)                                
      Inflammation, Acute                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           3 (5%)       1 (2%)                                
      Mediastinum, Inflammation                                     1 (2%)                                                          
      Pleura, Inflammation, Chronic Active                          1 (2%)                                                          
   Nose                                               (60)         (59)         (60)         (59)                                   
      Fungus                                          21 (35%)      7 (12%)     12 (20%)      5 (8%)                                
      Hyperkeratosis                                                             1 (2%)       2 (3%)                                
      Inflammation, Acute                             24 (40%)     11 (19%)     15 (25%)      5 (8%)                                
      Respiratory Epithelium, Hyperplasia                           1 (2%)       3 (5%)                                             
      Respiratory Epithelium, Metaplasia, Squamous     9 (15%)                   3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)          (3)                                    
      Hemorrhage                                                                              1 (33%)                               
      Necrosis                                                                                2 (67%)                               
      Lens, Cataract                                                             1 (100%)     1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (56)                                   
      Cyst                                             2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Nephropathy                                     56 (93%)     51 (85%)     50 (83%)     31 (55%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05145-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:47:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Mineralization                           2 (3%)                                                                       
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Transitional Epithelium, Hyperplasia             2 (3%)                                                                       
   Urinary Bladder                                    (58)         (57)         (58)         (55)                                   
      Calculus Gross Observation                                    3 (5%)                                                          
      Calculus Micro Observation Only                               3 (5%)                    1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
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