National Toxicology Program

National Toxicology Program
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TDMS Study 05145-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            TRICAPRYLIN


NTP Experiment-Test: 05145-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 20:48:00




       Facility:  TSI Mason Research

       Chemical CAS #:  538-23-8

       Lock Date:  12/26/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05145-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:48:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            7                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           13           15           17                                     
    Natural Death                                      4            7            4           13                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                                           1                                                  
    Terminal Sacrifice                                29           30           30           22                                     
    Natural Death                                      2                                      1                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (58)         (58)         (60)         (59)                                   
   Intestine Large, Colon                             (57)         (56)         (58)         (51)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Rectum                            (58)         (56)         (58)         (51)                                   
      Circumanal Gland, Adenoma                        1 (2%)                                                                       
   Intestine Large, Cecum                             (57)         (55)         (58)         (49)                                   
   Intestine Small, Duodenum                          (59)         (56)         (58)         (49)                                   
   Intestine Small, Jejunum                           (56)         (56)         (57)         (47)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (56)         (56)         (58)         (49)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (58)                                   
      Hepatocellular Adenoma                           1 (2%)                    3 (5%)       4 (7%)                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Mesentery                                          (9)          (14)         (4)          (6)                                    
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Ileum                                                                 1 (25%)                                            
   Pancreas                                           (59)         (59)         (59)         (57)                                   
      Acinus, Adenoma                                  2 (3%)       5 (8%)      11 (19%)      8 (14%)                               
      Acinus, Adenoma, Multiple                                     1 (2%)       2 (3%)      11 (19%)                               
   Pharynx                                            (1)          (1)                                                              
      Palate, Squamous Cell Carcinoma                               1 (100%)                                                        
   Salivary Glands                                    (60)         (59)         (58)         (58)                                   
   Stomach, Forestomach                               (60)         (60)         (59)         (59)                                   
      Squamous Cell Papilloma                                                    3 (5%)       8 (14%)                               
      Squamous Cell Papilloma, Multiple                                                       2 (3%)                                
   Stomach, Glandular                                 (60)         (58)         (59)         (57)                                   
   Tongue                                             (2)                       (1)                                                 
                                                             Page   2                                                               
NTP Experiment-Test: 05145-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:48:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                          2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (1)                                                 
      Leiomyoma                                                                  1 (100%)                                           
      Vena Cava, Chemodectoma Benign                   1 (100%)                                                                     
   Heart                                              (60)         (60)         (59)         (58)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (59)         (58)                                   
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (60)         (59)         (59)         (58)                                   
      Pheochromocytoma Malignant                       2 (3%)                    1 (2%)                                             
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                         10 (17%)      9 (15%)     13 (22%)      7 (12%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)       2 (3%)       3 (5%)       7 (12%)                               
   Islets, Pancreatic                                 (59)         (58)         (59)         (56)                                   
      Adenoma                                          3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
      Carcinoma                                        2 (3%)                                                                       
   Pituitary Gland                                    (60)         (57)         (59)         (58)                                   
      Pars Distalis, Adenoma                           8 (13%)      8 (14%)      5 (8%)       4 (7%)                                
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (57)         (56)         (59)         (54)                                   
      C-Cell, Adenoma                                  6 (11%)      7 (13%)      9 (15%)      2 (4%)                                
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (60)         (60)         (59)                                   
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Ileum                                                                 1 (2%)                                             
   Preputial Gland                                    (59)         (58)         (60)         (58)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05145-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:48:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Adenoma                                          6 (10%)      4 (7%)       6 (10%)      2 (3%)                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Bilateral, Adenoma                               1 (2%)       1 (2%)                                                          
   Prostate                                           (59)         (59)         (59)         (59)                                   
   Seminal Vesicle                                    (59)         (60)         (60)         (59)                                   
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Ileum                                                                 1 (2%)                                             
   Testes                                             (59)         (60)         (60)         (59)                                   
      Bilateral, Interstitial Cell, Adenoma           47 (80%)     44 (73%)     49 (82%)     37 (63%)                               
      Interstitial Cell, Adenoma                      10 (17%)      9 (15%)     10 (17%)     12 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (11)         (11)         (7)          (2)                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
   Lymph Node                                         (25)         (25)         (25)         (16)                                   
      Lumbar, Leiomyosarcoma, Metastatic,                                                                                           
          Intestine Small, Ileum                                                 1 (4%)                                             
      Mediastinal, Osteosarcoma, Metastatic, Bone                   1 (4%)                                                          
   Lymph Node, Mandibular                             (59)         (56)         (59)         (57)                                   
      Fibrosarcoma, Metastatic, Ear                                 1 (2%)                                                          
   Lymph Node, Mesenteric                             (58)         (59)         (60)         (55)                                   
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Ileum                                                                 1 (2%)                                             
   Spleen                                             (59)         (60)         (59)         (58)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Thymus                                             (56)         (55)         (56)         (53)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (48)         (47)         (47)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                     5 (10%)      2 (4%)       3 (6%)       2 (4%)                                
   Skin                                               (59)         (59)         (58)         (59)                                   
      Basal Cell Adenoma                               1 (2%)                                                                       
      Keratoacanthoma                                  2 (3%)       1 (2%)       3 (5%)                                             
      Schwannoma Malignant                             1 (2%)                                                                       
      Squamous Cell Papilloma                          4 (7%)       2 (3%)       2 (3%)       1 (2%)                                
      Trichoepithelioma                                             1 (2%)                                                          
      Pinna, Schwannoma Malignant                                   1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05145-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:48:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Neurofibroma                                          1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma                                                  1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                  2 (3%)                    1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                  1 (2%)                    1 (2%)                                
      Vertebra, Chordoma                               1 (2%)                                                                       
   Skeletal Muscle                                    (50)         (50)         (47)         (53)                                   
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Ileum                                                                 1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (58)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (3%)       2 (3%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Carcinosarcoma                                                                          1 (2%)                                
      Fibrosarcoma, Metastatic, Ear                    1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Mediastinum, Leiomyosarcoma, Metastatic,                                                                                      
           Intestine Small, Ileum                                                1 (2%)                                             
   Nose                                               (60)         (59)         (60)         (59)                                   
      Chondroma                                                                  1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Fibrosarcoma                                                               1 (100%)                                           
   Eye                                                (1)                       (1)          (3)                                    
   Harderian Gland                                    (1)                                                                           
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05145-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:48:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (56)                                   
      Carcinoma                                                                               1 (2%)                                
   Urinary Bladder                                    (58)         (57)         (58)         (55)                                   
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            23 (38%)     29 (48%)     23 (38%)      9 (15%)                               
      Lymphoma Malignant Histiocytic                                             1 (2%)       1 (2%)                                
      Mesothelioma Malignant                           5 (8%)       2 (3%)       2 (3%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05145-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            TRICAPRYLIN                                        Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 20:48:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ML/KG      2.5 MLKG     5.0 MLKG     10.0                                      
                                                                                          ML/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58          57          59          49                                       
     Total Primary Neoplasms                          151         146         172         131                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 57          54          59          49                                       
     Total Benign Neoplasms                           115         104         138         111                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          37          30          18                                       
     Total Malignant Neoplasms                         36          42          34          20                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           5           4           3                                       
     Total Metastatic Neoplasm                         29          12          25          15                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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