TDMS Study 05145-01 Pathology Tables
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
Facility: TSI Mason Research
Chemical CAS #: 538-23-8
Lock Date: 12/26/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 4| 4| 7| 4| 6| 7| 7| 6| 6| 4| 5| 7| 7| 4| 5| 4| 7|
DAY ON TEST | 8| 3| 7| 3| 3| 9| 0| 3| 6| 6| 3| 6| 8| 3| 3| 2| 8| 6| 4| 3| 0| 6| 9| 6| 3|
| 7| 7| 8| 7| 7| 1| 4| 7| 3| 4| 7| 4| 7| 7| 7| 5| 2| 3| 1| 7| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Adenomatous | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Acute | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X 1 X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 2 2 2|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Mixed Cell Focus | X X X |
Necrosis | 2 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinus, Atrophy | 1 3 2 1 1 2 3 2 1 3 2 2 1 2 1 2 2 1 2 2 |
Acinus, Basophilic Focus | |
Acinus, Hyperplasia | 1 1 2 2 1 |
Artery, Hyperplasia | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | |
Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 2 1 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell, Focal | 2 1 |
Hyperplasia, Basal Cell | 1 |
Ulcer | 1 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 3 2 2 1|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 4| 4| 7| 4| 6| 7| 7| 6| 6| 4| 5| 7| 7| 4| 5| 4| 7|
DAY ON TEST | 8| 3| 7| 3| 3| 9| 0| 3| 6| 6| 3| 6| 8| 3| 3| 2| 8| 6| 4| 3| 0| 6| 9| 6| 3|
| 7| 7| 8| 7| 7| 1| 4| 7| 3| 4| 7| 4| 7| 7| 7| 5| 2| 3| 1| 7| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 3 2 2 3 3 3 2 2 2 2 2 2 2 1 3|
Thrombosis | 3 4 3 3 |
Atrium, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hypoplasia | 4|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 2 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + M M + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + A|
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 1 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 4| 4| 7| 4| 6| 7| 7| 6| 6| 4| 5| 7| 7| 4| 5| 4| 7|
DAY ON TEST | 8| 3| 7| 3| 3| 9| 0| 3| 6| 6| 3| 6| 8| 3| 3| 2| 8| 6| 4| 3| 0| 6| 9| 6| 3|
| 7| 7| 8| 7| 7| 1| 4| 7| 3| 4| 7| 4| 7| 7| 7| 5| 2| 3| 1| 7| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Angiectasis | 2 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | |
Mediastinal, Pigmentation | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Lymphatic, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 1 |
Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 2 3|
Hematopoietic Cell Proliferation | 2 2 2 3 3 1 |
Infarct | |
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + M + + + +|
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 1 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2|
Infiltration Cellular, Histiocyte | 3 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 4| 4| 7| 4| 6| 7| 7| 6| 6| 4| 5| 7| 7| 4| 5| 4| 7|
DAY ON TEST | 8| 3| 7| 3| 3| 9| 0| 3| 6| 6| 3| 6| 8| 3| 3| 2| 8| 6| 4| 3| 0| 6| 9| 6| 3|
| 7| 7| 8| 7| 7| 1| 4| 7| 3| 4| 7| 4| 7| 7| 7| 5| 2| 3| 1| 7| 4| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | |
Hemorrhage | 2|
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 3 3 2 3 3 2 2 |
Inflammation, Acute | 1 3 3 3 4 2 3 2 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 2 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Nephropathy | 2 2 1 1 2 3 2 3 1 2 2 1 1 2 3 2 2 2 3 3 2 2 2 3|
Cortex, Mineralization | |
Transitional Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 3| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 0| 3| 7| 2| 3| 3|
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 3| 0| 7| 7| 3| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Adenomatous | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X|
Eosinophilic Focus | X X X X|
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Mixed Cell Focus | X X X |
Necrosis | 3 |
Thrombosis | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic Active | 2 |
Fat, Mineralization | 1 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinus, Atrophy | 2 2 1 1 1 2 1 1 2 1 2 2|
Acinus, Basophilic Focus | X |
Acinus, Hyperplasia | 2 2 2 2 1 |
Artery, Hyperplasia | 3 3 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pharynx | |
Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell, Focal | |
Hyperplasia, Basal Cell | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 3| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 0| 3| 7| 2| 3| 3|
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 3| 0| 7| 7| 3| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 2 3 3 3 2 3 3 2 2 3 3 2 2 2 2 2 1 2 3 3 3|
Thrombosis | 3|
Atrium, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hypoplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 2 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M + + + + + + M M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 1 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Inflammation, Chronic Active | 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + M + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 3| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 0| 3| 7| 2| 3| 3|
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 3| 0| 7| 7| 3| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Angiectasis | 2 3 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | |
Mediastinal, Pigmentation | 2 2 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis | 1 |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis | 2 |
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 3 2 3 |
Hematopoietic Cell Proliferation | 3 2 1 3 |
Infarct | 4 3 |
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + M + +|
Congestion | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + + + + + + M + + + M + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Histiocyte | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 3| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 0| 3| 7| 2| 3| 3|
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 3| 0| 7| 7| 3| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fungus | 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 3 3 2 2 2 2 2 3 |
Inflammation, Acute | 3 3 3 2 2 2 2 3 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 3 2 3 1 2 2 2 2 2 3 2 2 3 2 1 3 2 1 2 2 2 3 2|
Cortex, Mineralization | 3 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 3| 7| 6| 7| 7| | |
DAY ON TEST | 0| 3| 6| 6| 3| 0| 3| 9| 3| 3| | |
| 5| 7| 4| 3| 7| 6| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Hyperplasia, Adenomatous | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + A + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + A + + | 56 |
Inflammation, Acute | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X X | 35 1.0|
Clear Cell Focus | X X | 10 |
Eosinophilic Focus | | 7 |
Fatty Change, Diffuse | | 1 1.0|
Fatty Change, Focal | | 4 2.0|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia | 3 | 1 3.0|
Mixed Cell Focus | X | 7 |
Necrosis | 2 | 3 2.3|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Acinus, Atrophy | 1 1 2 3 1 | 37 1.7|
Acinus, Basophilic Focus | | 1 |
Acinus, Hyperplasia | 2 | 11 1.6|
Artery, Hyperplasia | | 2 3.0|
Artery, Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | | 10 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 3| 7| 6| 7| 7| | |
DAY ON TEST | 0| 3| 6| 6| 3| 0| 3| 9| 3| 3| | |
| 5| 7| 4| 3| 7| 6| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Basal Cell, Focal | | 2 1.5|
Hyperplasia, Basal Cell | | 2 1.0|
Ulcer | | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | 2 | 6 2.2|
Inflammation, Chronic Active | 2 | 2 2.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 3 1 2 3 2 3 3 4 3 | 53 2.4|
Thrombosis | | 5 3.2|
Atrium, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Hypoplasia | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 1 | 22 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 2 | 7 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 3 2.7|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 2 | 11 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 57 |
C-Cell, Hyperplasia | | 7 1.4|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 3| 7| 6| 7| 7| | |
DAY ON TEST | 0| 3| 6| 6| 3| 0| 3| 9| 3| 3| | |
| 5| 7| 4| 3| 7| 6| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Abscess | | 3 1.3|
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | | 3 1.3|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | 3 1 | 6 1.5|
Seminiferous Tubule, Atrophy | 1 | 6 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 11 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 25 |
Mediastinal, Angiectasis | | 3 2.3|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | 2 | 1 2.0|
Mediastinal, Pigmentation | | 3 2.3|
Pancreatic, Hyperplasia, Lymphoid | | 2 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Pancreatic, Lymphatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Angiectasis | | 1 1.0|
Ectasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Angiectasis | | 2 1.5|
Ectasia | 3 1 | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Developmental Malformation | X | 1 |
Fibrosis | 2 | 8 2.4|
Hematopoietic Cell Proliferation | 1 | 11 2.1|
Infarct | | 2 3.5|
Lymphoid Follicle, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Congestion | | 1 3.0|
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 3| 7| 6| 7| 7| | |
DAY ON TEST | 0| 3| 6| 6| 3| 0| 3| 9| 3| 3| | |
| 5| 7| 4| 3| 7| 6| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + | 51 |
Hemorrhage, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + | 50 |
Atrophy | | 3 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Fungus | | 1 1.0|
Hemorrhage | | 2 1.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 2 3 | 21 2.5|
Inflammation, Acute | 2 1 2 2 | 24 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 9 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 3| 7| 6| 7| 7| | |
DAY ON TEST | 0| 3| 6| 6| 3| 0| 3| 9| 3| 3| | |
| 5| 7| 4| 3| 7| 6| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 2 |
Nephropathy | 2 1 1 1 2 2 2 2 2 | 56 2.0|
Cortex, Mineralization | 1 | 2 2.0|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 8| 6| 3| 3| 3| 5| 3| 3| 2| 3| 6| 3| 3| 3| 2| 6| 3| 3| 7| 3| 3| 3| 9| 6| 9|
| 7| 3| 7| 7| 7| 9| 7| 7| 3| 7| 3| 7| 2| 7| 6| 3| 6| 7| 9| 7| 7| 7| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + A + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Congestion | |
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 2 2 2 |
Mixed Cell Focus | 2 X X X |
Necrosis, Focal | 2 |
Necrosis | 2 |
Centrilobular, Degeneration | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Thrombosis | |
Artery, Inflammation, Chronic Active | |
Fat, Hemorrhage | 2 |
Fat, Mineralization | |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 2 1 1 3 1 2 2 2 2 2 2 2 1 1 1 1|
Acinus, Hyperplasia | 1 2 2 2 2 |
Artery, Hyperplasia | |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell, Diffuse | |
Hyperplasia, Basal Cell, Focal | |
Hyperplasia, Basal Cell | 1 1 1|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 8| 6| 3| 3| 3| 5| 3| 3| 2| 3| 6| 3| 3| 3| 2| 6| 3| 3| 7| 3| 3| 3| 9| 6| 9|
| 7| 3| 7| 7| 7| 9| 7| 7| 3| 7| 3| 7| 2| 7| 6| 3| 6| 7| 9| 7| 7| 7| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 3 2 2 2 2 3 2 3 3 2 2 2 2 2 2 2 3 2 1|
Inflammation, Chronic Active | |
Thrombosis | 2 3 1 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + A + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | |
Pars Distalis, Congestion | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 2 2 1 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + A + + + + + + + + + +|
Fibrosis | |
C-Cell, Hyperplasia | 2 1 2 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Abscess | 2 |
Dilatation | |
Hyperplasia | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 8| 6| 3| 3| 3| 5| 3| 3| 2| 3| 6| 3| 3| 3| 2| 6| 3| 3| 7| 3| 3| 3| 9| 6| 9|
| 7| 3| 7| 7| 7| 9| 7| 7| 3| 7| 3| 7| 2| 7| 6| 3| 6| 7| 9| 7| 7| 7| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 1|
Seminiferous Tubule, Atrophy | 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Lymphatic, Ectasia | |
Mediastinal, Angiectasis | |
Mediastinal, Congestion | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation | |
Mediastinal, Lymphatic, Ectasia | |
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | 1 |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Infiltration Cellular, Histiocyte | 2 |
Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Developmental Malformation | |
Fibrosis | 3 1 2 3 3 2 |
Hematopoietic Cell Proliferation | 3 2 3 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + M M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M M + + + + + M + + + M + + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Developmental Malformation | |
Inflammation, Chronic Active | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 8| 6| 3| 3| 3| 5| 3| 3| 2| 3| 6| 3| 3| 3| 2| 6| 3| 3| 7| 3| 3| 3| 9| 6| 9|
| 7| 3| 7| 7| 7| 9| 7| 7| 3| 7| 3| 7| 2| 7| 6| 3| 6| 7| 9| 7| 7| 7| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 3 1 |
Inflammation, Acute | 3 |
Mediastinum, Inflammation | 3 |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 3 3 |
Inflammation, Acute | 2 2 2 3 2 1 |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 2 2 2 2 1 2 2 2 2 1 2 1 2 2 2 2 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 5| 4| 6| 7| 7| 7| 7| 4| 7| 6| 3| 4| 7| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 2| 6| 9| 2| 3| 3| 3| 6| 3| 6| 9| 6| 3| 7| 3| 3| 3| 1| 9| 3|
| 7| 6| 6| 7| 7| 4| 3| 1| 1| 7| 7| 7| 4| 7| 3| 1| 4| 6| 9| 6| 6| 6| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + A + +|
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X 2 |
Congestion | 2 |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 2 3 |
Mixed Cell Focus | X X |
Necrosis, Focal | |
Necrosis | 3 |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Thrombosis | 3 |
Artery, Inflammation, Chronic Active | 2 |
Fat, Hemorrhage | |
Fat, Mineralization | 2 |
Fat, Necrosis | 3 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 1 2 2 1 3 2 1 2 3 2 2 1 1 3 2 1|
Acinus, Hyperplasia | 2 1 2 2 |
Artery, Hyperplasia | 2 |
Artery, Inflammation, Chronic Active | 2 2 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell, Diffuse | 1 |
Hyperplasia, Basal Cell, Focal | 1|
Hyperplasia, Basal Cell | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Erosion | 2 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 5| 4| 6| 7| 7| 7| 7| 4| 7| 6| 3| 4| 7| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 2| 6| 9| 2| 3| 3| 3| 6| 3| 6| 9| 6| 3| 7| 3| 3| 3| 1| 9| 3|
| 7| 6| 6| 7| 7| 4| 3| 1| 1| 7| 7| 7| 4| 7| 3| 1| 4| 6| 9| 6| 6| 6| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 3 2 2 2 2 1 2 2 2 2 2 3 2 2|
Inflammation, Chronic Active | 3 |
Thrombosis | 3 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 3 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Congestion | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M A + +|
Fibrosis | 2 |
C-Cell, Hyperplasia | 3 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Abscess | 1 |
Dilatation | 3 |
Hyperplasia | 3 |
Inflammation, Acute | |
Necrosis | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | 2 2 1|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 5| 4| 6| 7| 7| 7| 7| 4| 7| 6| 3| 4| 7| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 2| 6| 9| 2| 3| 3| 3| 6| 3| 6| 9| 6| 3| 7| 3| 3| 3| 1| 9| 3|
| 7| 6| 6| 7| 7| 4| 3| 1| 1| 7| 7| 7| 4| 7| 3| 1| 4| 6| 9| 6| 6| 6| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 2 |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Lymphatic, Ectasia | 2 |
Mediastinal, Angiectasis | 3 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation | 2 |
Mediastinal, Lymphatic, Ectasia | 2 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Lymphatic, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + M + M + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Lymphatic, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Depletion Lymphoid | 1 |
Developmental Malformation | X |
Fibrosis | 2 2 2 3 2|
Hematopoietic Cell Proliferation | 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Developmental Malformation | X |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 5| 4| 6| 7| 7| 7| 7| 4| 7| 6| 3| 4| 7| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 2| 6| 9| 2| 3| 3| 3| 6| 3| 6| 9| 6| 3| 7| 3| 3| 3| 1| 9| 3|
| 7| 6| 6| 7| 7| 4| 3| 1| 1| 7| 7| 7| 4| 7| 3| 1| 4| 6| 9| 6| 6| 6| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 |
Inflammation, Acute | |
Mediastinum, Inflammation | |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + M + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Acute | 2 2 1 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 2 1 2 3 2 2 3 2 2 1 1 2 1 2 1 1 1 3 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + A + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 4| 6| 1| 7| 7| 7| 7| 4| 4| 7| | |
DAY ON TEST | 6| 7| 2| 3| 3| 3| 3| 6| 6| 3| | |
| 3| 8| 7| 7| 7| 7| 7| 4| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X | 39 |
Clear Cell Focus | X X X X | 20 2.0|
Congestion | | 1 2.0|
Eosinophilic Focus | X | 4 |
Fatty Change, Focal | | 2 1.0|
Hepatodiaphragmatic Nodule | X | 5 |
Hyperplasia | | 5 2.2|
Mixed Cell Focus | X | 7 2.0|
Necrosis, Focal | | 1 2.0|
Necrosis | | 2 2.5|
Centrilobular, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 14 |
Thrombosis | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Fat, Hemorrhage | | 1 2.0|
Fat, Mineralization | 2 | 2 2.0|
Fat, Necrosis | 3 | 8 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | 2 | 1 2.0|
Acinus, Atrophy | 2 3 2 1 2 2 1 | 41 1.8|
Acinus, Hyperplasia | 2 2 | 11 1.8|
Artery, Hyperplasia | | 1 2.0|
Artery, Inflammation, Chronic Active | | 4 2.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Metaplasia, Squamous | 1 | 14 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Basal Cell, Diffuse | | 1 1.0|
Hyperplasia, Basal Cell, Focal | | 1 1.0|
Hyperplasia, Basal Cell | 1 | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 4| 6| 1| 7| 7| 7| 7| 4| 4| 7| | |
DAY ON TEST | 6| 7| 2| 3| 3| 3| 3| 6| 6| 3| | |
| 3| 8| 7| 7| 7| 7| 7| 4| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Erosion | | 3 2.3|
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 3 1 2 3 3 2 2 2 2 | 53 2.2|
Inflammation, Chronic Active | | 1 3.0|
Thrombosis | | 7 2.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 1 1 | 20 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 56 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Congestion | | 1 3.0|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hyperplasia | 2 2 3 | 11 1.8|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 56 |
Fibrosis | | 1 2.0|
C-Cell, Hyperplasia | | 6 2.0|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Abscess | 2 1 | 4 1.5|
Dilatation | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 4| 6| 1| 7| 7| 7| 7| 4| 4| 7| | |
DAY ON TEST | 6| 7| 2| 3| 3| 3| 3| 6| 6| 3| | |
| 3| 8| 7| 7| 7| 7| 7| 4| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation, Acute | 1 | 1 1.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | 2 2 2 | 9 1.6|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Concretion | | 1 3.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 2 2 | 8 1.9|
Seminiferous Tubule, Atrophy | 3 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 11 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + | 25 |
Lymphatic, Ectasia | | 1 2.0|
Mediastinal, Angiectasis | 1 | 2 2.0|
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Mediastinal, Pigmentation | 3 | 2 2.5|
Mediastinal, Lymphatic, Ectasia | | 1 2.0|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 2.5|
Pancreatic, Lymphatic, Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Angiectasis | | 1 1.0|
Infiltration Cellular, Plasma Cell | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Ectasia | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | | 3 2.0|
Lymphatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 4| 6| 1| 7| 7| 7| 7| 4| 4| 7| | |
DAY ON TEST | 6| 7| 2| 3| 3| 3| 3| 6| 6| 3| | |
| 3| 8| 7| 7| 7| 7| 7| 4| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 1 3.0|
Depletion Lymphoid | | 1 1.0|
Developmental Malformation | | 1 |
Fibrosis | 2 3 | 13 2.3|
Hematopoietic Cell Proliferation | 1 1 1 | 9 1.7|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + M M | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + M | 59 |
Cyst Epithelial Inclusion | | 1 |
Developmental Malformation | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + | 50 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 | 6 1.8|
Inflammation, Acute | | 1 3.0|
Mediastinum, Inflammation | | 1 3.0|
Pleura, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | 3 | 7 2.4|
Inflammation, Acute | 3 2 | 11 2.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 4| 6| 1| 7| 7| 7| 7| 4| 4| 7| | |
DAY ON TEST | 6| 7| 2| 3| 3| 3| 3| 6| 6| 3| | |
| 3| 8| 7| 7| 7| 7| 7| 4| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Nephropathy | 2 3 3 1 2 2 1 1 1 | 51 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Calculus Gross Observation | X | 3 |
Calculus Micro Observation Only | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 8| 3| 6| 3| 3| 8| 6| 3| 3| 3| 6| 3| 2| 2| 3| 5| 9| 3| 3| 3| 3| 3| 0| 3|
| 3| 6| 6| 3| 5| 5| 7| 3| 5| 5| 4| 3| 4| 9| 1| 4| 7| 7| 4| 4| 5| 5| 5| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + M + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X|
Congestion | 2 |
Cyst Multilocular | |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | 1 1 |
Fibrosis | 3 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | |
Mixed Cell Focus | X |
Necrosis | 1 2 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Acinus, Atrophy | 1 2 2 2 2 2 1 2 2 1 2 2 1 2|
Acinus, Basophilic Focus | |
Acinus, Hyperplasia | 3 1 3 2 2 2 2 1 2 2 1 2|
Artery, Hyperplasia | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + M + + + + M + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
Erosion | |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell, Focal | 2 |
Hyperplasia, Basal Cell | 1 2 1 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 |
Hyperplasia, Lymphoid | 2 2 1|
Mineralization | 1 |
__________________________________________________________________________|
Tongue | + |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 8| 3| 6| 3| 3| 8| 6| 3| 3| 3| 6| 3| 2| 2| 3| 5| 9| 3| 3| 3| 3| 3| 0| 3|
| 3| 6| 6| 3| 5| 5| 7| 3| 5| 5| 4| 3| 4| 9| 1| 4| 7| 7| 4| 4| 5| 5| 5| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 3 2 3 2 3 3 3 3 3 2 3 3 3 2 2 3 3|
Infiltration Cellular, Histiocyte | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 2 1 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic | |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 2 2 2 |
Dilatation | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 8| 3| 6| 3| 3| 8| 6| 3| 3| 3| 6| 3| 2| 2| 3| 5| 9| 3| 3| 3| 3| 3| 0| 3|
| 3| 6| 6| 3| 5| 5| 7| 3| 5| 5| 4| 3| 4| 9| 1| 4| 7| 7| 4| 4| 5| 5| 5| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Angiectasis | 3 |
Mediastinal, Ectasia | 2 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | |
Mediastinal, Pigmentation | |
Pancreatic, Angiectasis | 3 |
Pancreatic, Ectasia | |
Pancreatic, Pigmentation | |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Ectasia | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 3 3 3 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Infarct | 3 |
Mineralization | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 8| 3| 6| 3| 3| 8| 6| 3| 3| 3| 6| 3| 2| 2| 3| 5| 9| 3| 3| 3| 3| 3| 0| 3|
| 3| 6| 6| 3| 5| 5| 7| 3| 5| 5| 4| 3| 4| 9| 1| 4| 7| 7| 4| 4| 5| 5| 5| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 1 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 2 2 2 3 3 |
Hyperkeratosis | 3 |
Inflammation, Acute | 2 2 1 2 2 2 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Infarct | 2 |
Nephropathy | 1 2 1 2 2 2 2 2 1 1 2 2 2 2 1 1 2 2 2 2 2 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 5| 4| 7| 4| 4| 7| 0| 4| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 4|
DAY ON TEST | 3| 6| 2| 3| 3| 8| 8| 6| 3| 6| 6| 3| 8| 6| 7| 1| 3| 3| 3| 3| 3| 0| 2| 3| 6|
| 6| 4| 8| 6| 6| 8| 7| 3| 4| 4| 4| 5| 3| 4| 8| 8| 5| 5| 5| 5| 4| 8| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Congestion | 2 |
Cyst Multilocular | X |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | |
Fibrosis | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 3 |
Mixed Cell Focus | X X X |
Necrosis | 2 |
Thrombosis | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
Thrombosis | 2 |
Acinus, Atrophy | 2 2 2 2 1 1 2 1 2 1 1 2 2 2 1 1 1|
Acinus, Basophilic Focus | 2 |
Acinus, Hyperplasia | 2 1 2 1 2 2 |
Artery, Hyperplasia | 2 |
Artery, Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperkeratosis | |
Hyperplasia, Basal Cell, Focal | 2 |
Hyperplasia, Basal Cell | 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 |
Hyperplasia, Lymphoid | 1 2 |
Mineralization | 1 2 2 |
__________________________________________________________________________|
Tongue | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 5| 4| 7| 4| 4| 7| 0| 4| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 4|
DAY ON TEST | 3| 6| 2| 3| 3| 8| 8| 6| 3| 6| 6| 3| 8| 6| 7| 1| 3| 3| 3| 3| 3| 0| 2| 3| 6|
| 6| 4| 8| 6| 6| 8| 7| 3| 4| 4| 4| 5| 3| 4| 8| 8| 5| 5| 5| 5| 4| 8| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 2 2 3 2 2 2 2 2 2 2 3 3 2 3 3 2|
Infiltration Cellular, Histiocyte | |
Thrombosis | X 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic | 2 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Dilatation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 2|
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 5| 4| 7| 4| 4| 7| 0| 4| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 4|
DAY ON TEST | 3| 6| 2| 3| 3| 8| 8| 6| 3| 6| 6| 3| 8| 6| 7| 1| 3| 3| 3| 3| 3| 0| 2| 3| 6|
| 6| 4| 8| 6| 6| 8| 7| 3| 4| 4| 4| 5| 3| 4| 8| 8| 5| 5| 5| 5| 4| 8| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Angiectasis | 3 |
Mediastinal, Ectasia | 3 2 2 2 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | 2 3 |
Mediastinal, Pigmentation | 2 2 2 |
Pancreatic, Angiectasis | |
Pancreatic, Ectasia | 2 |
Pancreatic, Pigmentation | 2 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ectasia | 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | 3 3 3 3 3 3 2 2 3 2 |
Hematopoietic Cell Proliferation | 1 3 1 1 2 2 3 3 3 1|
Hemorrhage | |
Infarct | |
Mineralization | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M + + M + + + + M + M + + + + M + M|
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + M + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 5| 4| 7| 4| 4| 7| 0| 4| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 4|
DAY ON TEST | 3| 6| 2| 3| 3| 8| 8| 6| 3| 6| 6| 3| 8| 6| 7| 1| 3| 3| 3| 3| 3| 0| 2| 3| 6|
| 6| 4| 8| 6| 6| 8| 7| 3| 4| 4| 4| 5| 3| 4| 8| 8| 5| 5| 5| 5| 4| 8| 3| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 3 2 2 2 3|
Hyperkeratosis | |
Inflammation, Acute | 3 1 1 3 2 2 2|
Respiratory Epithelium, Hyperplasia | 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 2 |
Infarct | |
Nephropathy | 2 1 3 2 2 1 1 3 1 2 2 2 2 1 3 2 2 1 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 6| 4| 7| 7| | |
DAY ON TEST | 7| 3| 8| 9| 3| 3| 8| 5| 3| 3| | |
| 0| 6| 7| 8| 6| 5| 7| 4| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 58 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + | 58 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X | 34 |
Clear Cell Focus | X X X X X | 22 |
Congestion | | 2 2.0|
Cyst Multilocular | | 1 |
Eosinophilic Focus | X | 6 |
Fatty Change, Diffuse | | 2 1.0|
Fibrosis | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 7 |
Hyperplasia | 2 | 2 2.5|
Mixed Cell Focus | X X X | 7 |
Necrosis | | 3 1.7|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Thrombosis | 2 | 2 2.0|
Acinus, Atrophy | 2 2 2 2 2 2 2 | 38 1.7|
Acinus, Basophilic Focus | | 1 2.0|
Acinus, Hyperplasia | 2 2 3 2 2 1 | 24 1.9|
Artery, Hyperplasia | | 1 2.0|
Artery, Inflammation, Chronic Active | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
Duct, Metaplasia, Squamous | 1 | 4 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Erosion | | 1 1.0|
Hyperkeratosis | | 1 2.0|
Hyperplasia, Basal Cell, Focal | | 2 2.0|
Hyperplasia, Basal Cell | | 10 1.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 6| 4| 7| 7| | |
DAY ON TEST | 7| 3| 8| 9| 3| 3| 8| 5| 3| 3| | |
| 0| 6| 7| 8| 6| 5| 7| 4| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 2 | 7 2.0|
Hyperplasia, Lymphoid | | 5 1.6|
Mineralization | 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + M + + + + | 59 |
Cardiomyopathy | 2 3 2 2 2 2 3 2 | 54 2.4|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Thrombosis | 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 2 2 2 1 2 2 2 | 22 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | | 3 2.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 3 2 | 10 2.0|
Pars Distalis, Vacuolization | | |
Cytoplasmic | | 1 2.0|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 1 1 2 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 6| 4| 7| 7| | |
DAY ON TEST | 7| 3| 8| 9| 3| 3| 8| 5| 3| 3| | |
| 0| 6| 7| 8| 6| 5| 7| 4| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Abscess | 2 | 6 2.3|
Dilatation | | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 6 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 7 1.9|
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 25 |
Mediastinal, Angiectasis | 2 | 3 2.7|
Mediastinal, Ectasia | | 5 2.2|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 2 2.5|
Mediastinal, Pigmentation | | 3 2.0|
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Pigmentation | | 1 2.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Ectasia | | 2 1.5|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Ectasia | | 2 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | 2 | 16 2.6|
Hematopoietic Cell Proliferation | | 11 1.9|
Hemorrhage | 2 | 1 2.0|
Infarct | | 1 3.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 6| 4| 7| 7| | |
DAY ON TEST | 7| 3| 8| 9| 3| 3| 8| 5| 3| 3| | |
| 0| 6| 7| 8| 6| 5| 7| 4| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M M M + | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + M + + + | 47 |
Atrophy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Edema | 2 | 2 1.5|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 4 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 12 2.5|
Hyperkeratosis | | 1 3.0|
Inflammation, Acute | 3 | 15 2.0|
Respiratory Epithelium, Hyperplasia | | 3 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 7| 6| 4| 7| 7| | |
DAY ON TEST | 7| 3| 8| 9| 3| 3| 8| 5| 3| 3| | |
| 0| 6| 7| 8| 6| 5| 7| 4| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 2 |
Hydronephrosis | | 1 2.0|
Infarct | | 1 2.0|
Nephropathy | 1 1 1 2 2 2 2 2 3 | 50 1.8|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 5| 2| 4| 4| 4| 4| 4| 7| 4| 2| 7| 7| 7| 7| 7| 3| 3| 7| 4| 3| 2| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 6| 6| 1| 4| 6| 2| 6| 9| 1| 3| 3| 3| 3| 2| 2| 2| 6| 2| 8| 2| 3| 4| 3|
| 9| 3| 3| 4| 5| 6| 4| 9| 4| 2| 5| 3| 3| 3| 4| 4| 4| 6| 4| 4| 8| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + A + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + A + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + A A + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + A + + + A + + + + + + + + + M + + + A +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + A A + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + A + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X|
Cyst | |
Eosinophilic Focus | X X |
Fatty Change, Focal | 2 1 |
Fibrosis | |
Hepatodiaphragmatic Nodule | X |
Hypertrophy | 2 |
Infarct | |
Mixed Cell Focus | X |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + + + M +|
Congestion | |
Acinus, Atrophy | 1 3 1 2 1 2 2 2 1 1 2|
Acinus, Hyperplasia | 2 2 2 2 2 2 3 2 3 3 1 2 2 4 2|
Artery, Hyperplasia | 2 |
Artery, Inflammation, Chronic Active | |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Duct, Metaplasia, Squamous | 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 |
Hyperplasia, Basal Cell, Diffuse | 1 |
Hyperplasia, Basal Cell, Focal | |
Hyperplasia, Basal Cell | 2 1 2 2 2 1 1 2 1 2|
Hyperplasia, Diffuse, Squamous | 1 |
Inflammation, Acute | 1 1 |
Mineralization, Focal | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 5| 2| 4| 4| 4| 4| 4| 7| 4| 2| 7| 7| 7| 7| 7| 3| 3| 7| 4| 3| 2| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 6| 6| 1| 4| 6| 2| 6| 9| 1| 3| 3| 3| 3| 2| 2| 2| 6| 2| 8| 2| 3| 4| 3|
| 9| 3| 3| 4| 5| 6| 4| 9| 4| 2| 5| 3| 3| 3| 4| 4| 4| 6| 4| 4| 8| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 1 2 2 3 2 2 3 2 2 3 3 2 2 2 3 2 2 3|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
Vacuolization Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 3 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + A + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Abscess | |
Cyst | X |
Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + M + + + + +|
Interstitial Cell, Hyperplasia | 2 1 1 2 2 |
Seminiferous Tubule, Atrophy | 2 |
Seminiferous Tubule, Giant Cell | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 5| 2| 4| 4| 4| 4| 4| 7| 4| 2| 7| 7| 7| 7| 7| 3| 3| 7| 4| 3| 2| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 6| 6| 1| 4| 6| 2| 6| 9| 1| 3| 3| 3| 3| 2| 2| 2| 6| 2| 8| 2| 3| 4| 3|
| 9| 3| 3| 4| 5| 6| 4| 9| 4| 2| 5| 3| 3| 3| 4| 4| 4| 6| 4| 4| 8| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Angiectasis | 3 2 2 2 |
Mediastinal, Pigmentation | |
Pancreatic, Angiectasis | |
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + M + + M + +|
Angiectasis | |
Ectasia | |
Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Developmental Malformation | |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 3 |
Infarct | |
Pigmentation | 3 3 3 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | M + + + + + + + + A + + + + + + + M + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + M + M M + + + + + M + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + A + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 5| 2| 4| 4| 4| 4| 4| 7| 4| 2| 7| 7| 7| 7| 7| 3| 3| 7| 4| 3| 2| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 6| 6| 1| 4| 6| 2| 6| 9| 1| 3| 3| 3| 3| 2| 2| 2| 6| 2| 8| 2| 3| 4| 3|
| 9| 3| 3| 4| 5| 6| 4| 9| 4| 2| 5| 3| 3| 3| 4| 4| 4| 6| 4| 4| 8| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
Fungus | 1 3 |
Hyperkeratosis | 2 |
Inflammation, Acute | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 3 |
Necrosis | 3 4 |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 2 1 1 2 1 2 2 1 1 1 1 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 3| 4| 3| 3| 3| 7| 3| 7| 7| 7| 6| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 4| 8| 3| 2| 2| 2| 2| 2| 3| 5| 3| 3| 3| 7| 6| 8| 3| 6| 3| 8| 2| 0|
| 3| 3| 3| 7| 3| 3| 2| 6| 2| 2| 8| 4| 6| 4| 4| 4| 4| 3| 5| 3| 3| 4| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + A + + + + + + + M|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + A + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Cyst | X |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X X |
Hypertrophy | |
Infarct | 4 |
Mixed Cell Focus | X X X |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Acinus, Atrophy | 1 2 2 3 1 2 2 1 2 1 1 2 1 2|
Acinus, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 1 2 2 1 |
Artery, Hyperplasia | 3 |
Artery, Inflammation, Chronic Active | 2 |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X |
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 |
Hyperplasia, Basal Cell, Diffuse | |
Hyperplasia, Basal Cell, Focal | 2 1 |
Hyperplasia, Basal Cell | 1 2 1 1 2 1|
Hyperplasia, Diffuse, Squamous | |
Inflammation, Acute | |
Mineralization, Focal | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 3|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 3| 4| 3| 3| 3| 7| 3| 7| 7| 7| 6| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 4| 8| 3| 2| 2| 2| 2| 2| 3| 5| 3| 3| 3| 7| 6| 8| 3| 6| 3| 8| 2| 0|
| 3| 3| 3| 7| 3| 3| 2| 6| 2| 2| 8| 4| 6| 4| 4| 4| 4| 3| 5| 3| 3| 4| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 3 2 2 1 2 3 2 3 2 3 2 2 3 3 2 3 3|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hypertrophy | 2|
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 1 1 2 3 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + M + + + + + M + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Abscess | 2 1|
Cyst | |
Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 1 2 |
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Giant Cell | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 3| 4| 3| 3| 3| 7| 3| 7| 7| 7| 6| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 4| 8| 3| 2| 2| 2| 2| 2| 3| 5| 3| 3| 3| 7| 6| 8| 3| 6| 3| 8| 2| 0|
| 3| 3| 3| 7| 3| 3| 2| 6| 2| 2| 8| 4| 6| 4| 4| 4| 4| 3| 5| 3| 3| 4| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Angiectasis | 2 1 1 2 |
Mediastinal, Pigmentation | |
Pancreatic, Angiectasis | 2 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Ectasia | 2 |
Lymphatic, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 1 |
Developmental Malformation | X |
Fibrosis | 2 3 1 2 2 |
Hematopoietic Cell Proliferation | 2 1 |
Infarct | 3 |
Pigmentation | |
Capsule, Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M M + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 3| 4| 3| 3| 3| 7| 3| 7| 7| 7| 6| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 4| 8| 3| 2| 2| 2| 2| 2| 3| 5| 3| 3| 3| 7| 6| 8| 3| 6| 3| 8| 2| 0|
| 3| 3| 3| 7| 3| 3| 2| 6| 2| 2| 8| 4| 6| 4| 4| 4| 4| 3| 5| 3| 3| 4| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Hyperkeratosis | |
Inflammation, Acute | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Necrosis | |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cyst | X |
Nephropathy | 3 2 1 2 1 1 2 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + A + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 7| 2| 2| 7| 4| | |
DAY ON TEST | 3| 9| 3| 2| 2| 3| 8| 9| 3| 8| | |
| 3| 0| 3| 3| 8| 3| 2| 2| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A A + A | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A A + A | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A A + A | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A A + A | 49 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A A + A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A A + A | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + A + + | 58 |
Basophilic Focus | X X X X X X X | 31 |
Clear Cell Focus | X X X | 13 |
Cyst | | 1 |
Eosinophilic Focus | | 3 |
Fatty Change, Focal | 2 | 3 1.7|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Hypertrophy | | 1 2.0|
Infarct | | 1 4.0|
Mixed Cell Focus | | 4 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + | 57 |
Congestion | | 1 2.0|
Acinus, Atrophy | 1 1 1 2 | 29 1.6|
Acinus, Hyperplasia | 2 2 1 2 2 | 35 2.1|
Artery, Hyperplasia | 2 | 3 2.3|
Artery, Inflammation, Chronic Active | 2 | 2 2.0|
Artery, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + | 58 |
Cyst | | 1 |
Duct, Metaplasia, Squamous | 1 | 8 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + | 59 |
Hyperkeratosis | 1 | 5 1.4|
Hyperplasia, Basal Cell, Diffuse | | 1 1.0|
Hyperplasia, Basal Cell, Focal | | 2 1.5|
Hyperplasia, Basal Cell | 1 2 1 1 | 20 1.5|
Hyperplasia, Diffuse, Squamous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 7| 2| 2| 7| 4| | |
DAY ON TEST | 3| 9| 3| 2| 2| 3| 8| 9| 3| 8| | |
| 3| 0| 3| 3| 8| 3| 2| 2| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 1 | 3 1.0|
Mineralization, Focal | 1 | 1 1.0|
Ulcer | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + A | 57 |
Erosion | 2 1 | 5 2.0|
Mineralization | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + M + + | 58 |
Cardiomyopathy | 2 2 2 2 2 3 | 49 2.3|
Thrombosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + A + + | 58 |
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + A + + | 58 |
Hyperplasia | 2 1 2 1 | 18 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A A + + | 56 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M | 53 |
Cyst | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 3 | 2 2.5|
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hyperplasia | 2 2 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A M + A | 54 |
C-Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Abscess | 3 | 3 2.0|
Cyst | | 1 |
Dilatation | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 7| 2| 2| 7| 4| | |
DAY ON TEST | 3| 9| 3| 2| 2| 3| 8| 9| 3| 8| | |
| 3| 0| 3| 3| 8| 3| 2| 2| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | | 10 1.6|
Seminiferous Tubule, Atrophy | 3 | 3 2.0|
Seminiferous Tubule, Giant Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + | 16 |
Mediastinal, Angiectasis | 3 | 9 2.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A M + + | 55 |
Angiectasis | | 2 2.5|
Ectasia | | 1 2.0|
Lymphatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + | 58 |
Depletion Lymphoid | | 3 1.7|
Developmental Malformation | | 1 |
Fibrosis | 2 2 | 9 2.0|
Hematopoietic Cell Proliferation | | 7 2.1|
Infarct | | 1 3.0|
Pigmentation | | 3 3.0|
Capsule, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + A M + M | 53 |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M + + M + + | 47 |
Galactocele | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + M + + | 59 |
Cyst | | 1 |
Hyperkeratosis | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05145-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRICAPRYLIN Date: 04/25/97
Route: GAVAGE Time: 08:07:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 7| 2| 2| 7| 4| | |
DAY ON TEST | 3| 9| 3| 2| 2| 3| 8| 9| 3| 8| | |
| 3| 0| 3| 3| 8| 3| 2| 2| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 53 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + M + + | 58 |
Edema | 1 | 2 1.5|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 4 1.5|
Inflammation, Acute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | 2 | 5 2.0|
Hyperkeratosis | 2 | 2 2.0|
Inflammation, Acute | 2 | 5 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + M + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Hemorrhage | | 1 3.0|
Necrosis | | 2 3.5|
Lens, Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + A + A | 56 |
Cyst | | 1 |
Nephropathy | 2 1 1 2 2 | 31 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A A + + | 55 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
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---------- END OF REPORT ----------
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