TDMS Study 05145-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/17/94
EXP: 05145 TRICAPRYLIN TIME: 20:57:59
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 62215
CONT: N01-ES-55123 CAS: 538-23-8
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/17/94
EXP: 05145 TRICAPRYLIN TIME: 20:57:59
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 62215
CONT: N01-ES-55123 CAS: 538-23-8
PATHOLOGIST: K. MURTHY S. EUSTIS
TRICAPRYLIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 ML/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 306 390 541 576 593 604 623 625 663 673 |
| 678 682 687 687 691 699 704 705 707 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5 MLKG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 127 379 386 391 524 579 592 593 632 659 |
| 663 666 678 687 690 691 718 721 723 726 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 463 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0 MLKG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 83 454 457 518 587 587 597 601 608 623 |
| 628 670 678 686 687 687 688 698 721 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
==================================================================================
TRICAPRYLIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10.0 ML/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 30 CENSORED DEATHS 7 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 233 282 288 292 292 322 322 322 324 324 |
| 324 328 328 356 415 426 446 447 483 483 |
| 485 485 569 590 608 623 645 674 715 726 |
| CENSORED DEATHS |
| 463 463 463 464 464 464 464 |
| |
==================================================================================
TRICAPRYLIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 ML/KG | 100.0 100.0 100.0 98.3 96.7 96.7 94.7 88.6 82.6 62.4 |
| | |
| | |
|2.5 MLKG | 100.0 98.3 98.3 98.3 93.3 93.3 91.3 85.2 79.1 60.9 |
| | |
| | |
|5.0 MLKG | 98.3 98.3 98.3 98.3 98.3 95.0 93.0 84.9 78.8 62.7 |
| | |
| | |
|10.0 | 100.0 100.0 98.3 76.7 75.0 62.0 62.0 58.0 52.0 46.0 |
|ML/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0 |
| ML/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.4% 60.9% 62.7% 46.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.286 P=0.944 P=1.000 P=0.014 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 622.8 591.3 592.5 438.6 |
|NATURAL DEATHS (C) | (25.0) (35.1) (33.4) (26.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 651.1 638.8 641.5 552.8 |
|(STANDARD ERROR) | (14.7) (17.4) (16.7) (22.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRICAPRYLIN
KAPLAN-MEIER SURVIVAL CURVES
0 ML/KG = 1
2.5 MLKG = 2
5.0 MLKG = 3
10.0 ML/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 3 2 4 1
| 3 2 4 4 1 21 3
96 + 44 21 33 3 1
| 2 2 1 1
| 4 4 3 2 13 1
| 2 1 1
P 88 + 3 31 1
E | 44 2 112
R | 33 12 1
C | 3 3 1 1
E 80 + 33 22
N | 4 4 3 211
T | 4 44 3211
| 4 4 33
S 72 + 33
U | 4 4 11
R | 211 2
V | 44 33
I 64 + 3 22
V | 4 4 1 3 1
A | 4 4 2 2
L | 4 4
56 + 4 4
| 4 4
| 4 4
| 4 4
48 + 44
| 4 4
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.