TDMS Study 05150-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
METHYLPHENIDATE HYDROCHLORIDE
NTP Experiment-Test: 05150-02 Report: PEIRPT03
Study Type: CHRONIC Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
Facility: TSI Mason Research
Chemical CAS #: 298-59-9
Lock Date: 02/19/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 69 69 70 70
Scheduled Sacrifice 20 19 20 20
Early Deaths
Natural Death 5 7 6
Accidently Killed 1
Moribund Sacrifice 6 7 7 6
Survivors
Terminal Sacrifice 36 34 37 44
Natural Death 1 1
Missing 1
Animals Examined Microscopically 69 68 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (64) (56) (63) (68)
Dilatation 1 (2%) 1 (1%)
Intestine Large, Cecum (67) (63) (65) (70)
Edema 1 (2%)
Hyperplasia, Lymphoid 30 (45%) 18 (29%) 18 (28%) 17 (24%)
Intestine Small, Jejunum (65) (63) (65) (70)
Hyperplasia, Lymphoid 1 (2%) 1 (1%)
Liver (69) (67) (69) (70)
Angiectasis 1 (1%) 1 (1%) 1 (1%)
Autolysis 1 (1%)
Basophilic Focus 2 (3%) 4 (6%) 3 (4%) 1 (1%)
Clear Cell Focus 2 (3%) 2 (3%)
Congestion 1 (1%)
Eosinophilic Focus 3 (4%) 3 (4%) 10 (14%) 27 (39%)
Fatty Change 1 (1%) 1 (1%) 8 (12%) 5 (7%)
Fatty Change, Focal 2 (3%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%) 2 (3%)
Hemorrhage 1 (1%)
Hyperplasia, Lymphoid 2 (3%) 1 (1%)
Necrosis, Focal 7 (10%) 4 (6%) 7 (10%) 13 (19%)
Mesentery (6) (1) (2)
Fat, Necrosis 5 (83%) 2 (100%)
Pancreas (68) (67) (69) (70)
Inflammation, Chronic, Focal 2 (3%) 2 (3%) 1 (1%) 1 (1%)
Acinus, Atrophy 1 (1%) 1 (1%) 2 (3%)
Duct, Ectasia 2 (3%) 1 (1%) 2 (3%)
Salivary Glands (69) (67) (70) (69)
Inflammation, Chronic, Focal 6 (9%) 7 (10%) 7 (10%) 9 (13%)
Stomach, Forestomach (67) (68) (69) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Abscess 1 (1%)
Diverticulum 1 (1%) 1 (1%)
Ulcer 1 (1%) 1 (1%)
Stomach, Glandular (68) (65) (68) (70)
Edema 1 (2%)
Erosion 2 (3%)
Inflammation, Chronic 1 (2%) 1 (1%)
Inflammation, Chronic, Focal 1 (1%)
Inflammation, Subacute 1 (1%)
Muscularis, Hypertrophy 1 (1%) 1 (1%)
Tongue (3) (1)
Angiectasis 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (68) (68) (69) (70)
Artery, Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (69) (67) (68) (70)
Congestion 1 (1%)
Cytoplasmic Alteration, Focal 2 (3%)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%)
Hyperplasia, Focal 1 (1%) 1 (1%)
Hypertrophy 1 (1%) 2 (3%)
Capsule, Hyperplasia 1 (1%)
Adrenal Medulla (67) (64) (66) (68)
Hyperplasia, Focal 1 (1%) 1 (2%)
Islets, Pancreatic (68) (67) (69) (70)
Hyperplasia 7 (10%) 9 (13%) 10 (14%) 11 (16%)
Hypoplasia 1 (1%)
Pituitary Gland (67) (66) (68) (67)
Pars Distalis, Angiectasis 1 (1%) 1 (2%) 1 (1%)
Pars Distalis, Hyperplasia, Focal 14 (21%) 10 (15%) 13 (19%) 11 (16%)
Thyroid Gland (69) (66) (68) (69)
Inflammation, Acute, Focal 1 (1%)
Inflammation, Chronic 1 (2%)
Follicle, Cyst 2 (3%) 1 (1%)
Follicular Cell, Hyperplasia, Focal 4 (6%) 11 (17%) 8 (12%) 5 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (41) (44) (46)
Abscess 1 (2%)
Angiectasis 1 (2%)
Cyst 1 (2%)
Dilatation 2 (5%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Ovary (65) (67) (69) (67)
Abscess 1 (1%)
Angiectasis 1 (1%)
Cyst 7 (11%) 13 (19%) 13 (19%) 9 (13%)
Mineralization, Focal 1 (1%) 1 (1%)
Thrombosis 1 (1%)
Uterus (69) (68) (69) (70)
Angiectasis 1 (1%) 3 (4%) 2 (3%) 2 (3%)
Fibrosis, Focal 1 (1%)
Hydrometra 6 (9%) 8 (12%) 6 (9%) 14 (20%)
Inflammation, Suppurative 1 (1%) 2 (3%)
Thrombosis 1 (1%)
Endometrium, Hyperplasia, Cystic 63 (91%) 62 (91%) 58 (84%) 61 (87%)
Endometrium, Metaplasia, Squamous 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (69) (68) (67) (70)
Angiectasis 1 (1%)
Hyperplasia, Neutrophil 2 (3%) 6 (9%) 5 (7%) 2 (3%)
Myelofibrosis 25 (36%) 21 (31%) 22 (33%) 21 (30%)
Lymph Node (7) (7) (8) (5)
Lumbar, Hematopoietic Cell Proliferation 1 (14%)
Lumbar, Lymphatic, Angiectasis 1 (13%)
Mediastinal, Hyperplasia, Lymphoid 1 (14%)
Mediastinal, Infiltration Cellular, Mixed
Cell 1 (13%)
Pancreatic, Hyperplasia, Lymphoid 1 (14%) 2 (25%)
Renal, Hematopoietic Cell Proliferation 1 (14%)
Lymph Node, Mandibular (67) (61) (68) (68)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (1%)
Necrosis 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymphatic, Angiectasis 1 (1%)
Lymph Node, Mesenteric (65) (66) (67) (67)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Lymphatic, Angiectasis 1 (2%) 3 (4%) 1 (1%)
Spleen (68) (67) (68) (70)
Congestion 1 (1%) 1 (1%) 2 (3%)
Depletion Lymphoid 1 (1%) 3 (4%) 3 (4%) 1 (1%)
Hematopoietic Cell Proliferation 8 (12%) 10 (15%) 13 (19%) 9 (13%)
Hyperplasia, Lymphoid 2 (3%) 1 (1%) 4 (6%) 2 (3%)
Necrosis, Focal 1 (1%) 1 (1%)
Thymus (65) (66) (67) (69)
Angiectasis 1 (1%)
Depletion Lymphoid 1 (2%) 2 (3%) 2 (3%)
Hyperplasia, Lymphoid 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (60) (63) (64)
Lactation 1 (2%) 2 (3%) 3 (5%) 2 (3%)
Skin (69) (68) (70) (70)
Inflammation, Chronic 1 (1%)
Ulcer 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (69) (68) (70) (70)
Hyperostosis 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (69) (68) (70) (70)
Compression 1 (1%) 1 (1%)
Hemorrhage, Focal 1 (1%)
Mineralization 42 (61%) 38 (56%) 36 (51%) 38 (54%)
Mineralization, Focal 2 (3%) 1 (1%) 1 (1%)
Artery, Inflammation, Chronic 1 (1%)
Spinal Cord (1)
Artery, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (68) (68) (69) (70)
Congestion 1 (1%) 1 (1%)
Hemorrhage, Focal 2 (3%) 2 (3%) 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
Thrombosis 1 (1%)
Alveolar Epithelium, Hyperplasia 4 (6%)
Peribronchial, Inflammation, Chronic 3 (4%) 1 (1%) 5 (7%)
Nose (69) (68) (70) (70)
Degeneration, Hyaline 8 (12%) 4 (6%) 7 (10%) 8 (11%)
Inflammation, Chronic 54 (78%) 49 (72%) 51 (73%) 56 (80%)
Inflammation, Chronic, Focal 10 (14%) 8 (12%) 10 (14%) 10 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (1) (4) (5)
Hyperplasia 1 (50%) 1 (25%) 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (69) (67) (70) (70)
Congestion 1 (1%) 1 (1%)
Fatty Change 2 (3%)
Glomerulosclerosis 2 (3%) 2 (3%) 1 (1%)
Hemorrhage, Focal 1 (1%)
Hyperplasia, Lymphoid 1 (1%) 1 (1%) 1 (1%)
Infarct 2 (3%) 2 (3%) 3 (4%)
Inflammation, Chronic, Focal 1 (1%)
Mineralization 1 (1%) 1 (1%)
Nephropathy 1 (1%) 1 (1%)
Renal Tubule, Degeneration, Granular 1 (1%) 2 (3%)
Renal Tubule, Necrosis 2 (3%)
Renal Tubule, Regeneration 7 (10%) 3 (4%) 3 (4%) 3 (4%)
Urinary Bladder (63) (59) (64) (70)
Inflammation, Chronic, Focal 8 (13%) 7 (12%) 9 (14%) 9 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund Sacrifice 2 2 4 4
Natural Death 3 3 2 5
Survivors
Terminal Sacrifice 45 45 43 41
Moribund Sacrifice 1
Animals Examined Microscopically 70 70 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (64) (67) (64) (62)
Ulcer 1 (2%)
Intestine Large, Cecum (68) (69) (68) (67)
Hyperplasia, Lymphoid 33 (49%) 18 (26%) 23 (34%) 24 (36%)
Intestine Small, Jejunum (68) (68) (67) (66)
Hyperplasia, Lymphoid 3 (4%) 1 (1%) 2 (3%) 1 (2%)
Inflammation, Acute 1 (1%) 1 (2%)
Ulcer 1 (1%)
Intestine Small, Ileum (66) (68) (67) (65)
Hyperplasia, Lymphoid 1 (2%)
Liver (70) (70) (70) (70)
Angiectasis 4 (6%) 2 (3%) 1 (1%)
Basophilic Focus 1 (1%) 2 (3%) 5 (7%) 1 (1%)
Clear Cell Focus 5 (7%) 3 (4%) 3 (4%) 6 (9%)
Eosinophilic Focus 6 (9%) 9 (13%) 9 (13%) 14 (20%)
Fatty Change 12 (17%) 13 (19%) 13 (19%) 24 (34%)
Fatty Change, Focal 2 (3%) 2 (3%)
Inflammation, Chronic, Focal 1 (1%) 1 (1%) 1 (1%)
Necrosis, Focal 3 (4%) 1 (1%) 4 (6%) 6 (9%)
Thrombosis 1 (1%) 1 (1%) 1 (1%)
Artery, Inflammation, Acute 1 (1%)
Mesentery (2) (3) (1) (2)
Cyst 1 (100%)
Hemorrhage, Focal 1 (50%)
Mineralization 1 (50%)
Fat, Necrosis 1 (50%) 2 (67%) 1 (50%)
Pancreas (70) (69) (69) (70)
Hyperplasia, Focal 2 (3%)
Inflammation, Chronic, Focal 1 (1%)
Salivary Glands (70) (70) (70) (70)
Inflammation, Chronic, Focal 2 (3%) 7 (10%) 4 (6%) 8 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (69) (70) (70) (70)
Foreign Body 1 (1%)
Hyperkeratosis, Focal 1 (1%)
Ulcer 2 (3%)
Stomach, Glandular (68) (69) (70) (67)
Erosion 1 (1%) 2 (3%) 2 (3%)
Hyperplasia 1 (1%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic 2 (3%) 1 (1%) 1 (1%) 3 (4%)
Mucosa, Hyperplasia, Focal 1 (1%)
Perivascular, Inflammation, Chronic 1 (1%)
Tongue (3) (1) (2)
Hemorrhage, Focal 1 (33%) 1 (50%)
Hyperkeratosis, Focal 1 (100%)
Pigmentation, Focal 1 (33%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (70) (70) (70)
Inflammation, Chronic, Focal 1 (1%)
Mineralization 1 (1%)
Ventricle, Hypertrophy 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (69) (69) (70) (70)
Atrophy 2 (3%)
Fibrosis 1 (1%)
Hyperplasia, Focal 14 (20%) 18 (26%) 15 (21%) 13 (19%)
Capsule, Hyperplasia 1 (1%) 1 (1%) 1 (1%)
Capsule, Hyperplasia, Focal 1 (1%)
Adrenal Medulla (68) (67) (69) (66)
Hyperplasia 1 (1%)
Hyperplasia, Focal 2 (3%)
Islets, Pancreatic (70) (68) (69) (70)
Atrophy 1 (1%)
Hyperplasia 24 (34%) 27 (40%) 22 (32%) 20 (29%)
Pituitary Gland (68) (68) (64) (64)
Pars Distalis, Cyst 1 (1%)
Thyroid Gland (70) (69) (69) (70)
Follicle, Cyst 1 (1%)
Follicular Cell, Hyperplasia 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (70) (70) (70)
Atrophy 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%)
Spermatocele 1 (1%) 1 (1%)
Preputial Gland (54) (53) (55) (54)
Abscess 1 (2%) 1 (2%)
Atrophy 1 (2%)
Cyst 36 (67%) 42 (79%) 42 (76%) 35 (65%)
Depletion Cellular 1 (2%)
Dilatation 28 (52%) 25 (47%) 25 (45%) 28 (52%)
Hemorrhage, Focal 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Acute 6 (11%) 8 (15%) 7 (13%) 4 (7%)
Inflammation, Chronic 9 (17%) 8 (15%) 9 (16%) 6 (11%)
Prostate (69) (69) (67) (65)
Atrophy 2 (3%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (1%) 2 (3%) 2 (3%)
Inflammation, Chronic, Focal 2 (3%)
Seminal Vesicle (70) (69) (70) (70)
Depletion Cellular 4 (6%) 2 (3%) 3 (4%) 2 (3%)
Dilatation 5 (7%) 5 (7%) 7 (10%) 3 (4%)
Fibrosis 1 (1%)
Testes (70) (70) (70) (70)
Hypospermia 1 (1%) 1 (1%) 1 (1%) 2 (3%)
Interstitial Cell, Hyperplasia 1 (1%)
Seminiferous Tubule, Atrophy 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70) (70) (69)
Hyperplasia, Neutrophil 2 (3%) 1 (1%) 3 (4%)
Myelofibrosis 1 (1%) 1 (1%) 1 (1%)
Lymph Node (3) (5) (1) (2)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (20%)
Pancreatic, Hyperplasia 2 (67%)
Renal, Lymphatic, Angiectasis 1 (50%)
Lymph Node, Mandibular (66) (65) (67) (66)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (68) (65) (65) (65)
Congestion 2 (3%) 3 (5%) 3 (5%) 2 (3%)
Fibrosis 1 (2%)
Hyperplasia 1 (1%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Thrombosis 1 (1%)
Spleen (69) (69) (69) (70)
Congestion 1 (1%) 1 (1%) 1 (1%)
Cyst 1 (1%)
Depletion Lymphoid 5 (7%) 3 (4%) 4 (6%) 1 (1%)
Fibrosis, Focal 2 (3%)
Hematopoietic Cell Proliferation 6 (9%) 7 (10%) 9 (13%) 8 (11%)
Hyperplasia, Lymphoid 1 (1%) 1 (1%)
Infiltration Cellular, Plasma Cell 1 (1%)
Thymus (58) (60) (58) (56)
Cyst 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (70) (70) (69) (70)
Inflammation, Chronic 1 (1%)
Ulcer 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70) (70) (70)
Hyperostosis 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70) (70) (70)
Compression 1 (1%)
Hemorrhage, Focal 1 (1%)
Mineralization 36 (51%) 42 (60%) 34 (49%) 34 (49%)
Mineralization, Focal 5 (7%) 3 (4%) 4 (6%) 5 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (69) (70) (70)
Angiectasis 1 (1%)
Congestion 1 (1%) 1 (1%)
Hemorrhage, Focal 5 (7%) 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (4%) 1 (1%) 4 (6%) 3 (4%)
Peribronchial, Inflammation, Chronic 4 (6%) 4 (6%) 7 (10%) 3 (4%)
Nose (70) (70) (70) (70)
Degeneration, Hyaline 3 (4%) 2 (3%)
Inflammation, Chronic 55 (79%) 53 (76%) 52 (74%) 52 (74%)
Inflammation, Chronic, Focal 11 (16%) 8 (11%) 10 (14%) 10 (14%)
Metaplasia, Squamous 1 (1%) 1 (1%) 1 (1%)
Olfactory Epithelium, Hyperplasia 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (5) (2) (2)
Hyperplasia 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (70)
Casts 1 (1%)
Cyst 1 (1%) 1 (1%) 1 (1%) 3 (4%)
Glomerulosclerosis 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Hemorrhage 1 (1%)
Hyperplasia, Lymphoid 2 (3%) 1 (1%)
Infarct 1 (1%) 2 (3%) 1 (1%) 1 (1%)
Inflammation, Chronic, Focal 2 (3%) 1 (1%)
Metaplasia, Osseous 1 (1%)
Mineralization 16 (23%) 14 (20%) 13 (19%) 18 (26%)
Nephropathy 1 (1%) 2 (3%) 1 (1%)
Renal Tubule, Degeneration, Granular 1 (1%) 2 (3%)
Renal Tubule, Regeneration 38 (54%) 37 (53%) 40 (57%) 36 (51%)
Urinary Bladder (68) (68) (68) (67)
Calculus Micro Observation Only 1 (1%) 1 (1%)
Concretion 1 (1%) 1 (1%)
Ectasia 1 (1%)
Inflammation, Chronic, Focal 1 (1%) 6 (9%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05150-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 05/20/95
Route: DOSED FEED Time: 09:59:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 50 PPM 250 PPM 500 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Perivascular, Inflammation, Chronic 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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