TDMS Study 05150-02 Pathology Tables
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
Facility: TSI Mason Research
Chemical CAS #: 298-59-9
Lock Date: 02/19/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 4 2 3 3 2 2 2 4|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | 3 |
Basophilic Focus | X X |
Congestion | 2 |
Eosinophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Necrosis, Focal | 2 1 1 |
__________________________________________________________________________|
Mesentery | +|
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Diverticulum | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hypertrophy | |
__________________________________________________________________________|
Tongue | + |
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
Capsule, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | M + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + M M + + M + + M M M M + + M + + M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 2 4 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + M +|
Cyst | |
Dilatation | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + M + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | 4 2 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 4 3 1 4 1 2 4 2 3 4 3 4 2 1 3 3 4 4 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | 2 3 1 2 1 1 4 2 |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Depletion Lymphoid | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 2 |
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + M M + + + + + + + + + +|
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + + + + + M + + + + + + + + +|
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization, Focal | 1 |
Mineralization | 2 1 2 2 1 1 2 1 2 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + M + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
Inflammation, Chronic | 3 |
Peribronchial, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 1 2 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 2 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | 3 |
Hemorrhage, Focal | 3 |
Hyperplasia, Lymphoid | |
Infarct | |
Mineralization | 4 |
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + M + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 4 4 3 2 3 3 3 3 4 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Autolysis | |
Basophilic Focus | |
Congestion | |
Eosinophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
Necrosis, Focal | 2 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Diverticulum | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hypertrophy | 3 |
__________________________________________________________________________|
Tongue | + + |
Angiectasis | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 1 |
Capsule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M + M M I + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia, Focal | 4 1 2 2 2 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + M M + + + + + +|
Cyst | |
Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + M M + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 4 4 |
Inflammation, Suppurative | 4 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 4 1 1 2 3 4 1 3 3 4 3 3 4 1 3 3 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
Myelofibrosis | 2 2 1 1 1 1 3 1 2 4 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hematopoietic Cell | |
Proliferation | 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Renal, Hematopoietic Cell | |
Proliferation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + I + + + + +|
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + M + + + + M + + +|
Congestion | |
Depletion Lymphoid | |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 1 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + M + + + +|
Lactation | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Mineralization, Focal | |
Mineralization | 2 2 3 1 2 2 2 1 2 1 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 4 |
Inflammation, Chronic | |
Peribronchial, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 |
Inflammation, Chronic, Focal | 1 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | 3 |
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | |
Infarct | |
Mineralization | |
Renal Tubule, Degeneration, Granular | 3 |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + M A + + +|
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 67 |
Hyperplasia, Lymphoid | 2 2 2 2 3 3 2 4 | 30 2.8|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | | 1 1.0|
Autolysis | | 1 3.0|
Basophilic Focus | | 2 |
Congestion | | 1 2.0|
Eosinophilic Focus | X X X | 3 |
Fatty Change | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Necrosis, Focal | 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 3 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Chronic, Focal | | 2 1.5|
Duct, Ectasia | | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic, Focal | 2 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + | 67 |
Abscess | 3 | 1 3.0|
Diverticulum | 3 | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 68 |
Muscularis, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 3 |
Angiectasis | | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Focal | | 1 1.0|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 67 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia | 2 4 | 7 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M M M + + M M + + + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + | 67 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 3 4 | 14 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 69 |
Follicular Cell, Hyperplasia, Focal | 2 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + | 43 |
Cyst | X | 1 |
Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + | 65 |
Cyst | X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | | 1 3.0|
Hydrometra | 2 4 | 6 3.3|
Inflammation, Suppurative | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 2 1 1 1 3 1 3 1 2 3 3 3 2 2 4 | 63 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Neutrophil | 2 | 2 3.0|
Myelofibrosis | 1 2 2 2 | 25 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 67 |
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 65 |
Congestion | | 1 4.0|
Depletion Lymphoid | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 68 |
Congestion | | 1 2.0|
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 | 8 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + | 65 |
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + M + M + + + + M + M + + + | 59 |
Lactation | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 69 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 69 |
Compression | | 1 4.0|
Mineralization, Focal | 2 | 2 1.5|
Mineralization | 2 2 3 2 1 2 3 3 2 2 3 1 | 42 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 68 |
Congestion | | 1 2.0|
Hemorrhage, Focal | 2 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Peribronchial, Inflammation, Chronic | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 69 |
Degeneration, Hyaline | 2 2 2 | 8 1.9|
Inflammation, Chronic, Focal | 2 2 2 2 | 10 1.9|
Inflammation, Chronic | 2 2 2 2 2 2 3 2 2 1 2 2 2 | 54 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 69 |
Fatty Change | | 2 2.0|
Glomerulosclerosis | | 2 3.0|
Hemorrhage, Focal | | 1 3.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Infarct | 2 3 | 2 2.5|
Mineralization | | 1 4.0|
Renal Tubule, Degeneration, Granular | | 1 3.0|
Renal Tubule, Regeneration | 1 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + | 63 |
Inflammation, Chronic, Focal | 2 | 8 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4|
DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5|
| 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + M + + M + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 3 2 3 3 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X |
Clear Cell Focus | |
Eosinophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2|
Acinus, Atrophy | 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 3 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + I + + + + + + + + + + + + I + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4|
DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5|
| 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M M M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 4 4 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Hyperplasia, Focal | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + M + + + + + + + |
Dilatation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Mineralization, Focal | |
Thrombosis | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 3 1 3 4 1 3 3 1 1 3 3 3 2 3 2 3 1 2 1 4 2 2|
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 2 |
Myelofibrosis | 2 2 3 2 2 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + + M + + + + + + +|
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 2 |
Hyperplasia, Lymphoid | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + M + + + + + + + + + + +|
Lactation | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4|
DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5|
| 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Mineralization | 2 2 3 2 1 2 3 2 3 2 2 1 1 2 1 1|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Spinal Cord | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 2 |
Thrombosis | |
Peribronchial, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 2 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7|
DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4|
| 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + A + + + + + + A + + A + + + + + A +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + A + + + + + A +|
Hyperplasia, Lymphoid | 4 4 4 2 3 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + A + + + + + + A + + A + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Edema | 2 |
Erosion | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 3 4 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7|
DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4|
| 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + + + + + M + M + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | 4 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | 4 |
Follicular Cell, Hyperplasia, Focal | 2 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + M + + +|
Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Mineralization, Focal | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Hydrometra | 4 4 3 4 |
Endometrium, Hyperplasia, Cystic | 2 3 2 1 4 1 2 1 2 3 4 3 3 1 3 3 2 3 2 2 2 3|
Endometrium, Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 2 3 |
Myelofibrosis | 1 2 4 2 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + M + + +|
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 |
Hematopoietic Cell Proliferation | 3 4 3 4 4 |
Hyperplasia, Lymphoid | 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + M + + + M + + + + + + +|
Lactation | X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7|
DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4|
| 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Mineralization | 2 2 2 3 2 1 2 3 3 2 2 3|
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spinal Cord | + |
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 4 |
Thrombosis | 1 |
Peribronchial, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | |
Renal Tubule, Necrosis | 4 3 |
Renal Tubule, Regeneration | 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + A + A + + + + + + A + + A + + + + + A +|
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Gallbladder | + M M + A + + + + + + + + + + + + A + | 56 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + | 63 |
Hyperplasia, Lymphoid | 3 4 2 2 | 18 2.9|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + A + | 62 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + A + | 63 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A + | 61 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + | 67 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | | 4 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | | 3 |
Fatty Change | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Necrosis, Focal | | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + | 67 |
Inflammation, Chronic, Focal | | 2 2.0|
Acinus, Atrophy | | 1 4.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + | 67 |
Inflammation, Chronic, Focal | 2 | 7 1.9|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + A + | 65 |
Edema | | 1 2.0|
Erosion | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 68 |
Artery, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + A + + + + + + + + + + + + + + | 67 |
Cytoplasmic Alteration, Focal | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + A + + + + + + + + + + + + + + | 64 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + | 67 |
Hyperplasia | 4 2 | 9 2.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M M + + M M M M + + + + M M + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + M + + + + + + + + + + | 66 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 4 3 | 10 3.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + | 66 |
Inflammation, Chronic | | 1 4.0|
Follicular Cell, Hyperplasia, Focal | 2 2 1 1 | 11 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 41 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + A + + + + + + + + + + + + + + | 67 |
Cyst | X X X X X X | 13 |
Mineralization, Focal | 3 | 1 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 68 |
Angiectasis | 2 | 3 2.7|
Hydrometra | 2 4 4 | 8 3.5|
Endometrium, Hyperplasia, Cystic | 3 2 2 3 3 2 4 3 4 3 4 3 2 2 3 4 1 3 | 62 2.5|
Endometrium, Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia, Neutrophil | 3 4 | 6 3.0|
Myelofibrosis | 2 1 2 3 1 1 | 21 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + A + + + + + + + + + M + + + + | 61 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + | 66 |
Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | 4 | 3 3.0|
Hematopoietic Cell Proliferation | 3 1 4 | 10 3.2|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + A + + + + + + + + + + + + + M | 66 |
Depletion Lymphoid | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + M + + + M | 60 |
Lactation | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 68 |
Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 68 |
Hemorrhage, Focal | | 1 3.0|
Mineralization | 2 2 3 1 3 3 3 2 1 2 | 38 2.1|
Artery, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Artery, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 68 |
Congestion | 3 | 1 3.0|
Hemorrhage, Focal | | 2 3.0|
Thrombosis | | 1 1.0|
Peribronchial, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 68 |
Degeneration, Hyaline | | 4 2.0|
Inflammation, Chronic, Focal | 2 2 2 | 8 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 1 2 | 49 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + | 67 |
Congestion | | 1 3.0|
Glomerulosclerosis | 4 3 | 2 3.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal Tubule, Necrosis | | 2 3.5|
Renal Tubule, Regeneration | 2 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + M + + + + + + + + A + | 59 |
Inflammation, Chronic, Focal | 1 | 7 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + A + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | 3 3 3 2 3 2 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X |
Fatty Change, Focal | 1 1 |
Fatty Change | 2 1 1 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 1 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | |
Muscularis, Hypertrophy | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
Hypoplasia | 2|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 3 3 3 4 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + |
Abscess | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Angiectasis | |
Cyst | X X X X |
Mineralization, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 4 4 |
Endometrium, Hyperplasia, Cystic | 4 4 3 2 1 2 3 3 4 2 3 3 2 3 3 4 3 3 3 2 3 2 2|
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
Myelofibrosis | 1 2 1 3 2 3 1 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Lymphatic, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Mixed Cell | |
Pancreatic, Hyperplasia, Lymphoid | 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Depletion Lymphoid | 2 4 |
Hematopoietic Cell Proliferation | 4 2 |
Hyperplasia, Lymphoid | 2 1 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + M M|
Lactation | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Mineralization, Focal | 1|
Mineralization | 2 2 2 1 2 2 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Chronic | |
Peribronchial, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2|
Inflammation, Chronic, Focal | 2 2|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
Infarct | |
Inflammation, Chronic, Focal | |
Nephropathy | 2 |
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Regeneration | 1 1|
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + M + A + + + + + + + + +|
Inflammation, Chronic, Focal | 1 1 2|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + M + + + A + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + A + + + + + + A + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 3 2 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + A + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + A + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + A + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X|
Fatty Change, Focal | |
Fatty Change | 1 2 |
Hematopoietic Cell Proliferation | 3 2 |
Necrosis, Focal | 4 3 1 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic | |
Muscularis, Hypertrophy | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + A + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Hypoplasia | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M M M M M + + M + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 4 4 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + A + + + + + + + + +|
Abscess | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | |
Cyst | X X X X X |
Mineralization, Focal | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + A + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 4 |
Endometrium, Hyperplasia, Cystic | 3 3 2 4 1 3 2 2 4 2 4 3 2 2 2 1 2 3 4 3|
Endometrium, Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + A + + M + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
Myelofibrosis | 1 1 1 3 2 3 1|
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Lymphatic, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Mixed Cell | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + A + + + + + + + + + M + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M A + + + + + + + + + + + + + + + +|
Lymphatic, Angiectasis | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 3 3 2 3 3 |
Hyperplasia, Lymphoid | 3 |
Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +|
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization, Focal | |
Mineralization | 3 2 1 2 3 2 1 2 1 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Inflammation, Chronic | |
Peribronchial, Inflammation, Chronic | 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 2 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 |
Inflammation, Chronic | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Infarct | 3 |
Inflammation, Chronic, Focal | |
Nephropathy | |
Renal Tubule, Degeneration, Granular | 4 4 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + A + + + + + + A + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 65 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 2 1 4 3 2 3 4 | 18 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 65 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 3 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X | 10 |
Fatty Change, Focal | | 2 1.0|
Fatty Change | 1 1 1 | 8 1.3|
Hematopoietic Cell Proliferation | | 2 2.5|
Necrosis, Focal | 2 | 7 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic, Focal | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 1 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 |
Diverticulum | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Muscularis, Hypertrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + M + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | 1 1 2 2 2 4 | 10 2.0|
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + + + M + + M + + M | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + | 68 |
Pars Distalis, Hyperplasia, Focal | 3 | 13 3.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + | 68 |
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia, Focal | 1 1 3 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + M + + + + + + | 44 |
Abscess | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 69 |
Abscess | | 1 4.0|
Angiectasis | 3 | 1 3.0|
Cyst | X X X X | 13 |
Mineralization, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | 1 3 | 2 2.0|
Hydrometra | 4 4 4 | 6 4.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 2 3 1 3 2 3 3 4 3 3 | 58 2.6|
Endometrium, Metaplasia, Squamous | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 67 |
Hyperplasia, Neutrophil | 2 3 3 | 5 3.2|
Myelofibrosis | 1 1 1 1 2 | 22 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + | 8 |
Lumbar, Lymphatic, Angiectasis | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Mixed Cell | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 67 |
Lymphatic, Angiectasis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 68 |
Congestion | | 1 3.0|
Depletion Lymphoid | 1 | 3 2.3|
Hematopoietic Cell Proliferation | 3 4 2 3 4 | 13 3.1|
Hyperplasia, Lymphoid | 2 | 4 2.0|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + | 67 |
Depletion Lymphoid | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + M + + | 63 |
Lactation | X X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | | 1 3.0|
Mineralization, Focal | | 1 1.0|
Mineralization | 2 2 3 2 2 1 2 2 2 2 1 | 36 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + M + + + + + + + + + + | 69 |
Hemorrhage, Focal | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Peribronchial, Inflammation, Chronic | 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Hyaline | 2 | 7 2.0|
Inflammation, Chronic, Focal | 2 2 2 | 10 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 51 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + M + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | 2 | 2 2.5|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Nephropathy | | 1 2.0|
Renal Tubule, Degeneration, Granular | | 2 4.0|
Renal Tubule, Regeneration | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 64 |
Inflammation, Chronic, Focal | 2 | 9 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2 2 2 3 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X X |
Fatty Change | 1 1 |
Necrosis, Focal | 1 1 1 2 1 1 2 4 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Tongue | |
Angiectasis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + M + + M M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | 1 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis, Focal | 2 |
Hydrometra | 4 4 2 4 3 2 |
Inflammation, Suppurative | 4 4 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 1 2 1 3 2 2 3 1 1 3 4 1 3 1 2 1 2 2 3 2 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia, Neutrophil | 4 |
Myelofibrosis | 1 1 3 1 2 2 |
__________________________________________________________________________|
Lymph Node | + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 4 4 3 4 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + M + + + + + + + + + +|
Lactation | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Mineralization | 2 2 1 2 2 2 1 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 2 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Infarct | 4 2 |
Mineralization | 1 |
Nephropathy | |
Renal Tubule, Regeneration | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X X X X X X X X X X |
Fatty Change | 1 2 1 |
Necrosis, Focal | 3 1 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 1 2 2 1 2 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Tongue | + |
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M M + M M M + M + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Angiectasis | 2|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + +|
Angiectasis | |
__________________________________________________________________________|
Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis, Focal | |
Hydrometra | 4 3 2 |
Inflammation, Suppurative | |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 1 2 1 2 1 2 2 4 2 2 3 2 3 1 4 2 2 3 1 4 1 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Neutrophil | |
Myelofibrosis | 1 2 1 1 1 1 2|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphatic, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 1 |
Hematopoietic Cell Proliferation | 4 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lactation | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 |
Mineralization | 1 2 1 3 1 2 1 2 1 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Infarct | 2 |
Mineralization | |
Nephropathy | |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + | 68 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Lymphoid | 3 2 2 4 1 2 3 | 17 2.4|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | | 1 |
Eosinophilic Focus | X X X X X X X X X | 27 |
Fatty Change | | 5 1.2|
Necrosis, Focal | 2 | 13 1.8|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 1 2.0|
Acinus, Atrophy | 3 | 2 3.5|
Duct, Ectasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + | 69 |
Inflammation, Chronic, Focal | | 9 1.8|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Angiectasis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 2 2 4 3 1 | 11 1.9|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + M + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 3 2 | 11 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Acute, Focal | | 1 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | 3 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M M + + + + + + + + + | 46 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + + + + + + + + + + + | 67 |
Cyst | X X | 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 2 | 2 2.5|
Fibrosis, Focal | | 1 2.0|
Hydrometra | 3 2 4 4 4 | 14 3.2|
Inflammation, Suppurative | | 2 4.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 3 4 1 2 1 3 4 3 3 2 2 | 61 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 4.0|
Hyperplasia, Neutrophil | 3 | 2 3.5|
Myelofibrosis | 2 2 1 3 3 2 1 4 | 21 1.8|
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + | 68 |
Lymphatic, Angiectasis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + M + + + + + + + | 67 |
Lymphatic, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 1 1.0|
Hematopoietic Cell Proliferation | 4 4 | 9 3.7|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + M M + + + + + + + + + + + | 64 |
Lactation | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization, Focal | | 1 1.0|
Mineralization | 2 1 2 1 2 2 2 1 1 2 2 1 | 38 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar Epithelium, Hyperplasia | | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Hyaline | 2 2 | 8 2.0|
Inflammation, Chronic, Focal | 2 2 | 10 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 56 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Glomerulosclerosis | 1 | 1 1.0|
Infarct | | 3 2.7|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 2 | 1 2.0|
Renal Tubule, Regeneration | | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 2 | 9 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + M + + + + + M + + + + M + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 3 2 2 3 3 2 2 2 3|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | |
Clear Cell Focus | X|
Eosinophilic Focus | X X X|
Fatty Change, Focal | |
Fatty Change | 1 2 1 2 |
Necrosis, Focal | 1 1 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage, Focal | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | + |
Hemorrhage, Focal | |
Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ventricle, Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 2 2 3 1 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + + M + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | 2|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X X X X X X X X X X X X X X|
Dilatation | 3 3 2 3 4 3 4 |
Hemorrhage, Focal | |
Inflammation, Acute | 3 3 |
Inflammation, Chronic | 3 3 4 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 1 |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + I + + + + + + + M + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 3 2 2 1 2 1 2 2 2 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage, Focal | 2 2 2 |
Alveolar Epithelium, Hyperplasia | |
Peribronchial, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | 4 |
Hyperplasia, Lymphoid | |
Infarct | |
Mineralization | 1 1 1 1 1 3 |
Nephropathy | |
Renal Tubule, Degeneration, Granular | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 2 1 1 2 2 1 1 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic, Focal | |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 3 3 2 2 2 2 3 4 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 |
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Fatty Change, Focal | 1 |
Fatty Change | 2 2 2 3 |
Necrosis, Focal | 3 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage, Focal | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | |
Hemorrhage, Focal | |
Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ventricle, Hypertrophy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 2 2 1 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 4 2 2 2 1 2 4 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + I M M + M + + + + + + + + + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X X X X X X X X X |
Dilatation | 3 3 3 3 3 3 4 4 3 4 4 3|
Hemorrhage, Focal | 2 |
Inflammation, Acute | 4 4 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Dilatation | 2 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | 2 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 1 1 1 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 4 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + M + + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 |
Mineralization | 3 3 2 2 2 3 3 1 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage, Focal | |
Alveolar Epithelium, Hyperplasia | 1 |
Peribronchial, Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 1 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 3 2 |
Infarct | 2 |
Mineralization | 1 1 1 1 2 1 1 |
Nephropathy | |
Renal Tubule, Degeneration, Granular | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 2 1 1 1 2 2 1 2 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Perivascular, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + | 64 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + | 68 |
Hyperplasia, Lymphoid | 3 3 3 2 2 2 1 2 3 | 33 2.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + | 67 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + | 68 |
Hyperplasia, Lymphoid | 4 4 | 3 4.0|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + A + + + | 66 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 4 1.5|
Basophilic Focus | X | 1 |
Clear Cell Focus | X X | 5 |
Eosinophilic Focus | | 6 |
Fatty Change, Focal | 1 | 2 1.0|
Fatty Change | 1 2 1 2 | 12 1.8|
Necrosis, Focal | | 3 1.7|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Hemorrhage, Focal | | 1 2.0|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 |
Foreign Body | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + | 68 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Hemorrhage, Focal | 4 | 1 4.0|
Pigmentation, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Ventricle, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + | 69 |
Atrophy | 2 2 | 2 2.0|
Hyperplasia, Focal | 3 2 2 2 2 | 14 1.9|
Capsule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M + + + + + + M + + + | 68 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 3 1 3 1 1 1 2 | 25 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + M + M + + + + + M M + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Spermatocele | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + | 54 |
Abscess | 4 | 1 4.0|
Cyst | X X X X X X X X X | 36 |
Dilatation | 4 3 4 4 4 3 3 3 2 | 28 3.3|
Hemorrhage, Focal | | 1 2.0|
Inflammation, Acute | 4 | 6 3.7|
Inflammation, Chronic | 4 3 4 | 9 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | 1 2 2 | 4 1.8|
Dilatation | 3 | 5 3.2|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypospermia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 17 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Pancreatic, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + M | 66 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + | 68 |
Congestion | | 2 2.0|
Hyperplasia | | 1 2.0|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | 2 | 1 2.0|
Depletion Lymphoid | 3 | 5 1.4|
Fibrosis, Focal | | 2 2.5|
Hematopoietic Cell Proliferation | 4 4 | 6 3.5|
__________________________________________________________________________|____________|
Thymus | M + + + M + + M + + + M + + + M M + + + | 58 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization, Focal | 2 | 5 1.8|
Mineralization | 3 2 2 2 2 2 2 3 2 | 36 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 2.0|
Hemorrhage, Focal | 2 2 | 5 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 3 1.3|
Peribronchial, Inflammation, Chronic | | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 2 2 2 2 | 11 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 55 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X | 1 |
Glomerulosclerosis | | 1 4.0|
Hyperplasia, Lymphoid | | 2 2.5|
Infarct | | 1 2.0|
Mineralization | 1 2 2 | 16 1.3|
Nephropathy | 2 | 1 2.0|
Renal Tubule, Degeneration, Granular | 4 | 1 4.0|
Renal Tubule, Regeneration | 3 2 1 1 2 1 2 1 1 1 1 2 1 | 38 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + | 68 |
Inflammation, Chronic, Focal | | 1 1.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4|
| 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 3 2 3 3 4 2 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Fatty Change | 3 2 2 |
Inflammation, Chronic, Focal | |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Mucosa, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 2 2 2 2 |
Capsule, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + A + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 3 3 2 2 3 2 4|
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + + + M M + M + + + + + + + I + + + M|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4|
| 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X X X|
Dilatation | 3 2 3 3 2 4 3 |
Inflammation, Acute | 3 4 4 4 |
Inflammation, Chronic | 4 1 3 1 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 2 |
Dilatation | 3 4|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + I + + + M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + A + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + A + + + + M + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4|
| 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 2 3 3 2 2 2 2 3 2 3 3 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | |
Peribronchial, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | 2 |
Hemorrhage | |
Infarct | |
Inflammation, Chronic, Focal | 1 |
Mineralization | 2 3 2 1 1 1 1 1|
Renal Tubule, Regeneration | 2 2 3 2 1 2 1 2 1 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + A + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7|
| 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 4 2 3 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Fatty Change | 2 2 2 2 1 2 2 |
Inflammation, Chronic, Focal | |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 |
Capsule, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 3 3 1 2 3 2 3 3 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + M + + + + + + + + + + + M + + M M|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7|
| 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + |
Cyst | X X X X X X X X X X X X X X |
Dilatation | 4 4 2 3 4 3 4 3 2 |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 2 |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + M + + +|
Congestion | 4 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 2 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7|
| 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 |
Mineralization | 2 3 2 2 2 2 2 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Hemorrhage, Focal | |
Infiltration Cellular, Histiocyte | 4 |
Inflammation, Chronic | 3 |
Alveolar Epithelium, Hyperplasia | |
Peribronchial, Inflammation, Chronic | 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 1 2 2 2|
Inflammation, Chronic | 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Hemorrhage | |
Infarct | |
Inflammation, Chronic, Focal | 2 |
Mineralization | 1 1 |
Renal Tubule, Regeneration | 1 1 1 2 3 2 2 2 2 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Chronic, Focal | 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Lymphoid | 2 2 2 2 | 18 2.8|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 2 | 2 1.5|
Basophilic Focus | | 2 |
Clear Cell Focus | X X | 3 |
Eosinophilic Focus | X X X X | 9 |
Fatty Change | 2 1 2 | 13 1.9|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 2 3 | 7 1.9|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 69 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Focal | 2 2 2 3 2 2 2 2 | 18 2.1|
Capsule, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 67 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + | 68 |
Hyperplasia | 3 3 2 3 2 3 2 | 27 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + M M M + M + + + + + + + M M | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 53 |
Cyst | X X X X X X X X X X X X X | 42 |
Dilatation | 2 4 4 2 4 4 4 4 4 | 25 3.2|
Inflammation, Acute | 3 3 | 8 3.6|
Inflammation, Chronic | 3 | 8 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 |
Depletion Cellular | | 2 2.5|
Dilatation | 4 4 | 5 3.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypospermia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Neutrophil | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + | 65 |
Congestion | | 3 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 3.0|
Cyst | | 1 |
Depletion Lymphoid | 1 1 1 | 3 1.0|
Hematopoietic Cell Proliferation | 2 | 7 2.9|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + M + + + M + + M + | 60 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization, Focal | | 3 2.0|
Mineralization | 2 3 1 1 3 2 2 1 2 3 2 2 3 3 | 42 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Peribronchial, Inflammation, Chronic | | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 2 | 8 1.9|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2 | 53 2.0|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X | 1 |
Glomerulosclerosis | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Infarct | 4 3 | 2 3.5|
Inflammation, Chronic, Focal | | 2 1.5|
Mineralization | 1 1 2 1 | 14 1.4|
Renal Tubule, Regeneration | 2 2 3 2 1 2 2 2 3 1 2 | 37 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 68 |
Calculus Micro Observation Only | | 1 |
Inflammation, Chronic, Focal | 1 | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7|
DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3|
| 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M M + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 3 2 3 3|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Fatty Change | 1 1 2 2 1 1 2 |
Inflammation, Chronic, Focal | 2 |
Necrosis, Focal | 1 1 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | |
Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7|
DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3|
| 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + + M + + + M + M + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + M + + + M + + M + + + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + +|
Abscess | |
Atrophy | 2 |
Cyst | X X X X X X X X X X X X X|
Dilatation | 3 3 4 4 3 4 3 4|
Inflammation, Acute | |
Inflammation, Chronic | 2 3 4 |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 2 3 |
Dilatation | 4 3 |
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 4 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Congestion | 4 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | 2 1 2 |
Hematopoietic Cell Proliferation | 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7|
DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3|
| 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + I + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 1 1 |
Mineralization | 2 3 1 2 2 2 2 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
Alveolar Epithelium, Hyperplasia | 2 |
Peribronchial, Inflammation, Chronic | 1 2 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | |
Olfactory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | |
Infarct | |
Metaplasia, Osseous | 3|
Mineralization | 1 1 1 1 1|
Nephropathy | 2 |
Renal Tubule, Regeneration | 1 2 1 1 1 3 1 1 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Ectasia | |
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4|
DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5|
| 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 3 3 2 3 3 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Fatty Change | 2 3 |
Inflammation, Chronic, Focal | |
Necrosis, Focal | 3 |
Thrombosis | X |
__________________________________________________________________________|
Mesentery | + |
Cyst | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 2 2 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 1 2 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4|
DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5|
| 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M M M + + M + M + + + + + + M I M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Abscess | 3 |
Atrophy | |
Cyst | X X X X X X X X X X X X X X X X X X |
Dilatation | 3 1 3 4 2 2 2 2 2 |
Inflammation, Acute | 4 4 4 2 4 4 |
Inflammation, Chronic | 4 2 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | 4 4 |
Fibrosis | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Congestion | 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 4 3 |
__________________________________________________________________________|
Thymus | + M M + + + + M + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4|
DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5|
| 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Mineralization | 3 2 2 3 1 2 2 3 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Alveolar Epithelium, Hyperplasia | 1 |
Peribronchial, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | |
Olfactory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Glomerulosclerosis | |
Hyperplasia, Lymphoid | 3 |
Infarct | 2 |
Metaplasia, Osseous | |
Mineralization | 2 1 1 1 1 1 |
Nephropathy | |
Renal Tubule, Regeneration | 2 1 1 1 1 1 1 2 1 1 2 1 3 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Ectasia | |
Inflammation, Chronic, Focal | 1|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + + M + + + + M + | 64 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + | 68 |
Hyperplasia, Lymphoid | 3 3 3 3 4 2 2 3 | 23 2.8|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + M | 67 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + | 67 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 2.0|
Basophilic Focus | X | 5 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | X X X X | 9 |
Fatty Change | 2 3 2 2 | 13 1.8|
Inflammation, Chronic, Focal | | 1 2.0|
Necrosis, Focal | 1 | 4 1.5|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 4 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperkeratosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | 2 | 2 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Perivascular, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperkeratosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Focal | 2 2 1 1 2 2 | 15 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | 1 2 2 1 3 1 4 2 2 | 22 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + M + M + + + M + M M | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 55 |
Abscess | | 1 3.0|
Atrophy | | 1 2.0|
Cyst | X X X X X X X X X X X | 42 |
Dilatation | 3 4 2 4 4 4 4 3 | 25 3.1|
Inflammation, Acute | 4 | 7 3.7|
Inflammation, Chronic | 4 | 9 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + A + + + + M + + + + | 67 |
Atrophy | | 2 2.5|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | | 3 2.7|
Dilatation | 4 4 3 | 7 3.7|
Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypospermia | | 1 4.0|
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Neutrophil | 2 | 1 2.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + | 67 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + M + M + | 65 |
Congestion | | 3 3.0|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | | 1 2.0|
Depletion Lymphoid | 3 | 4 2.0|
Hematopoietic Cell Proliferation | 3 4 4 3 | 9 3.4|
__________________________________________________________________________|____________|
Thymus | + M + + M + + + M + + + + + + + + M M + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 69 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization, Focal | | 4 1.3|
Mineralization | 2 2 2 2 2 2 2 2 3 1 2 2 | 34 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 2.0|
Hemorrhage, Focal | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 4 1.8|
Peribronchial, Inflammation, Chronic | 2 1 | 7 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Hyaline | 1 | 3 1.7|
Inflammation, Chronic, Focal | 2 2 2 | 10 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 52 2.0|
Metaplasia, Squamous | 2 | 1 2.0|
Olfactory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 1 |
Glomerulosclerosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infarct | | 1 2.0|
Metaplasia, Osseous | | 1 3.0|
Mineralization | 1 1 | 13 1.1|
Nephropathy | 4 | 2 3.0|
Renal Tubule, Regeneration | 1 1 2 1 2 1 2 1 1 2 2 1 1 | 40 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + A + + + | 68 |
Concretion | | 1 2.0|
Ectasia | 4 | 1 4.0|
Inflammation, Chronic, Focal | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + A + + A M + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 2 2 3 2 3 2 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X |
Fatty Change, Focal | 2 |
Fatty Change | 1 2 2 3 3 3 2 1 1 2 |
Inflammation, Chronic, Focal | |
Necrosis, Focal | 3 |
Thrombosis | X |
Artery, Inflammation, Acute | 4 |
__________________________________________________________________________|
Mesentery | |
Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + A + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | + |
Hemorrhage, Focal | |
Pigmentation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Fibrosis | 2 |
Hyperplasia, Focal | 2 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 1 3 4 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M + M + + + + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + M + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X X|
Depletion Cellular | |
Dilatation | 4 4 4 3 4 4 3 4 4|
Infiltration Cellular, Plasma Cell | |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | 2 4 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 3 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Thymus | + I + + + + M + + + + M + M I + M + M + M M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Focal | |
Mineralization, Focal | 2 |
Mineralization | 2 2 1 1 1 2 1 2 3 1 2 1 2 1 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Peribronchial, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | |
Cyst | X |
Glomerulosclerosis | 2 |
Infarct | |
Inflammation, Chronic, Focal | |
Mineralization | 1 1 1 1 1 |
Nephropathy | |
Renal Tubule, Degeneration, Granular | 3 |
Renal Tubule, Regeneration | 2 2 1 1 1 1 3 2 1 1 2 1 2|
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Concretion | |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 2 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X|
Fatty Change, Focal | 2 |
Fatty Change | 1 2 2 2 1 |
Inflammation, Chronic, Focal | |
Necrosis, Focal | |
Thrombosis | |
Artery, Inflammation, Acute | |
__________________________________________________________________________|
Mesentery | + |
Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 2 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Inflammation, Chronic | 2 2 1 |
__________________________________________________________________________|
Tongue | + |
Hemorrhage, Focal | 3 |
Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Fibrosis | |
Hyperplasia, Focal | 2 2 2 2 1 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | I + + + + + + + + + + + + + + + + + + + + I + + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 4 3 1 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + M + M + + + M + M M M M + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + M + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
Depletion Cellular | 2|
Dilatation | 4 4 2 4 3 4 3 4 3 3 2 4 |
Infiltration Cellular, Plasma Cell | |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M M + + M + + + + +|
Atrophy | |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | |
Renal, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + M + + +|
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + M + + + + + + + +|
Congestion | |
Fibrosis | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Focal | |
Mineralization, Focal | 1 1 1 1 |
Mineralization | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Peribronchial, Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | |
Cyst | |
Glomerulosclerosis | |
Infarct | |
Inflammation, Chronic, Focal | |
Mineralization | 1 1 1 1 1 1 |
Nephropathy | 2|
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Regeneration | 1 2 1 1 2 2 1 1 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Concretion | |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + | 62 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + A + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 67 |
Hyperplasia, Lymphoid | 2 2 3 3 3 3 3 3 3 3 | 24 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 66 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 65 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 6 |
Eosinophilic Focus | X X X X X X | 14 |
Fatty Change, Focal | | 2 2.0|
Fatty Change | 1 2 2 2 1 2 2 2 2 | 24 1.8|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Necrosis, Focal | 1 2 1 1 4 | 6 2.0|
Thrombosis | | 1 |
Artery, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Mineralization | 4 | 1 4.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 8 1.6|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Ulcer | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 67 |
Erosion | 2 2 | 2 2.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | | 3 1.7|
__________________________________________________________________________|____________|
Tongue | | 2 |
Hemorrhage, Focal | | 1 3.0|
Pigmentation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis | | 1 2.0|
Hyperplasia, Focal | 2 2 2 2 2 1 | 13 1.8|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + | 66 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 3 | 1 3.0|
Hyperplasia | 3 1 2 2 4 2 2 | 20 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + M M + + + M + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + | 54 |
Cyst | X X X X X X X X X X X X X X | 35 |
Depletion Cellular | | 1 2.0|
Dilatation | 4 3 4 4 4 3 4 | 28 3.6|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Inflammation, Acute | | 4 4.0|
Inflammation, Chronic | 3 4 4 | 6 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + M + + + + + + + + + + + + + | 65 |
Atrophy | 3 | 1 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | 2 4 | 2 3.0|
Dilatation | 3 | 3 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypospermia | 2 2 | 2 2.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Neutrophil | 4 3 | 3 3.3|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Renal, Lymphatic, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + A + | 66 |
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + A + | 65 |
Congestion | 2 | 2 2.0|
Fibrosis | | 1 2.0|
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 4 | 8 3.1|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + M + M + + + M + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M + M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | 4 | 1 4.0|
Hemorrhage, Focal | 3 | 1 3.0|
Mineralization, Focal | | 5 1.2|
Mineralization | 1 3 2 2 2 3 2 1 2 1 2 3 | 34 1.8|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05150-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:53:50
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| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | T (*) |
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| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
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RESPIRATORY SYSTEM - cont | | |
| | |
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Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
Peribronchial, Inflammation, Chronic | | 3 1.3|
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Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Hyaline | | 2 2.0|
Inflammation, Chronic, Focal | 2 | 10 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 52 2.1|
Metaplasia, Squamous | | 1 2.0|
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Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
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SPECIAL SENSES SYSTEM | | |
| | |
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Harderian Gland | + | 2 |
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URINARY SYSTEM | | |
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Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Casts | X | 1 |
Cyst | X X | 3 |
Glomerulosclerosis | | 1 2.0|
Infarct | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Mineralization | 2 2 1 2 2 1 2 | 18 1.3|
Nephropathy | | 1 2.0|
Renal Tubule, Degeneration, Granular | 4 | 2 3.5|
Renal Tubule, Regeneration | 1 1 1 2 2 1 1 2 2 2 1 2 | 36 1.5|
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Urinary Bladder | + + + + + + + + + + + + + + + + + + A + | 67 |
Calculus Micro Observation Only | | 1 |
Concretion | 3 | 1 3.0|
Perivascular, Inflammation, Chronic | 2 | 1 2.0|
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* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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