National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2342

TDMS Study 05155-04 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        P-NITROBENZOIC ACID


NTP Experiment-Test: 05155-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: DOSED FEED                                                                                                 Time: 19:10:43




       Facility:  Southern Research Institute

       Chemical CAS #:  62-23-7

       Lock Date:  02/19/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            8           12           10                                     
    Natural Death                                      3            5            4            8                                     
    Accidently Killed                                                            1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           36           33           30                                     
  Missing                                                           1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (58)         (57)         (58)                                   
      Dilatation                                                                              1 (2%)                                
      Inflammation, Subacute                                        1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (56)         (57)         (56)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
      Peyer's Patch, Necrosis                                                                 1 (2%)                                
   Liver                                              (60)         (59)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       1 (2%)                    1 (2%)                                
      Basophilic Focus                                 1 (2%)       5 (8%)       1 (2%)       2 (3%)                                
      Clear Cell Focus                                                                        1 (2%)                                
      Developmental Malformation                                    1 (2%)                                                          
      Eosinophilic Focus                               4 (7%)       6 (10%)      6 (10%)      2 (3%)                                
      Fatty Change, Focal                                           1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       3 (5%)       1 (2%)       2 (3%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Subacute                           3 (5%)                                 4 (7%)                                
      Karyomegaly                                                                1 (2%)                                             
      Mineralization                                                1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 3 (5%)       3 (5%)       1 (2%)                                             
      Necrosis                                         2 (3%)       3 (5%)       2 (3%)       2 (3%)                                
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic                        3 (5%)       2 (3%)       1 (2%)       1 (2%)                                
      Bile Duct, Cyst                                                            1 (2%)                                             
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Hepatocyte, Hypertrophy, Diffuse                                           1 (2%)                                             
   Mesentery                                          (5)          (8)          (6)          (7)                                    
      Cyst                                             1 (20%)                                                                      
      Inflammation, Subacute                                        2 (25%)      1 (17%)      1 (14%)                               
      Pigmentation, Hemosiderin                        1 (20%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Polyarteritis                                                 1 (13%)                                                         
      Fat, Hemorrhage                                  1 (20%)                                1 (14%)                               
      Fat, Inflammation, Granulomatous                 1 (20%)                                                                      
      Fat, Inflammation, Subacute                                                             1 (14%)                               
      Fat, Inflammation, Suppurative                                             1 (17%)                                            
      Fat, Necrosis                                    3 (60%)      4 (50%)      4 (67%)      2 (29%)                               
   Pancreas                                           (60)         (57)         (59)         (59)                                   
      Basophilic Focus                                                                        1 (2%)                                
      Congestion                                                    1 (2%)                                                          
      Edema                                            1 (2%)                    1 (2%)       2 (3%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Acinus, Atrophy                                  1 (2%)                    1 (2%)       3 (5%)                                
      Acinus, Depletion Secretory                      1 (2%)       2 (4%)       3 (5%)       3 (5%)                                
      Duct, Cyst                                       2 (3%)       1 (2%)       2 (3%)       3 (5%)                                
      Duct, Degeneration                                            1 (2%)                                                          
      Duct, Inflammation, Chronic                                   1 (2%)                                                          
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
      Cytoplasmic Alteration                                                                  1 (2%)                                
   Stomach, Forestomach                               (60)         (59)         (59)         (59)                                   
      Diverticulum                                     1 (2%)                                                                       
      Hyperplasia                                      7 (12%)      5 (8%)       4 (7%)       1 (2%)                                
      Inflammation, Subacute                           2 (3%)                    3 (5%)       1 (2%)                                
      Polyarteritis                                                 1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (59)         (58)         (59)         (59)                                   
      Cyst                                             1 (2%)       3 (5%)       4 (7%)       1 (2%)                                
      Erosion                                                       2 (3%)       1 (2%)       1 (2%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Polyarteritis                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                 1 (2%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Coronary Artery, Amyloid Deposition                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (58)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy                                      3 (5%)       2 (3%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
      Spindle Cell, Hyperplasia                                     1 (2%)                                                          
      X-Zone, Vacuolization Cytoplasmic                2 (3%)       5 (9%)       1 (2%)       2 (3%)                                
   Adrenal Medulla                                    (59)         (58)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)                                 1 (2%)                                
   Islets, Pancreatic                                 (60)         (59)         (59)         (60)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (58)         (58)         (58)         (58)                                   
      Pars Distalis, Angiectasis                                    1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                                           1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                      11 (19%)     10 (17%)     14 (24%)     11 (19%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      C-Cell, Hyperplasia                                                        1 (2%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)       3 (5%)       2 (3%)                                
      Follicle, Degeneration                                                                  1 (2%)                                
      Follicular Cell, Hyperplasia                    17 (28%)     14 (24%)     24 (40%)      8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (59)         (60)         (59)                                   
      Inflammation, Subacute                                                                  1 (2%)                                
      Duct, Cyst                                       3 (5%)       9 (15%)     11 (18%)     11 (19%)                               
   Ovary                                              (60)         (58)         (59)         (58)                                   
      Abscess                                          2 (3%)       2 (3%)                    6 (10%)                               
      Angiectasis                                      2 (3%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Cyst                                            17 (28%)     13 (22%)     18 (31%)     15 (26%)                               
      Hemorrhage                                                                              5 (9%)                                
      Inflammation, Subacute                                                                  1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Follicle, Hemorrhage                                                       1 (2%)                                             
   Oviduct                                                                      (1)                                                 
      Cyst                                                                       1 (100%)                                           
   Uterus                                             (60)         (59)         (60)         (60)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Atrophy                                                                    1 (2%)       2 (3%)                                
      Cyst                                                          1 (2%)       2 (3%)                                             
      Dilatation                                       7 (12%)     11 (19%)      8 (13%)      6 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                       3 (5%)       1 (2%)                                                          
      Hyperplasia, Cystic                             51 (85%)     55 (93%)     57 (95%)     46 (77%)                               
      Inflammation, Subacute                                                                  1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
   Vagina                                             (1)                       (1)                                                 
      Inflammation, Granulomatous                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (58)         (60)                                   
      Atrophy                                                                    1 (2%)                                             
      Hypercellularity                                 5 (8%)       1 (2%)       1 (2%)       4 (7%)                                
      Myeloid Cell, Depletion Cellular                                                        1 (2%)                                
   Lymph Node                                         (8)          (10)         (15)         (15)                                   
      Axillary, Hyperplasia, Lymphoid                               1 (10%)                                                         
      Iliac, Hyperplasia, Lymphoid                     2 (25%)                   3 (20%)      3 (20%)                               
      Inguinal, Hyperplasia, Lymphoid                  1 (13%)                                3 (20%)                               
      Mediastinal, Edema                                                                      1 (7%)                                
      Mediastinal, Hyperplasia, Lymphoid               3 (38%)      2 (20%)      1 (7%)       1 (7%)                                
      Mediastinal, Inflammation, Subacute                                                     2 (13%)                               
      Pancreatic, Hyperplasia, Lymphoid                                          1 (7%)                                             
      Renal, Hyperplasia                               1 (13%)                                                                      
      Renal, Hyperplasia, Lymphoid                     4 (50%)      2 (20%)                   3 (20%)                               
      Renal, Inflammation, Subacute                                                           1 (7%)                                
   Lymph Node, Mandibular                             (60)         (59)         (60)         (59)                                   
      Angiectasis                                                   2 (3%)                                                          
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    2 (3%)                                
      Infiltration Cellular, Mast Cell                 1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (59)         (59)         (58)         (58)                                   
      Angiectasis                                      3 (5%)       4 (7%)       5 (9%)       5 (9%)                                
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (60)         (59)         (59)         (60)                                   
      Atrophy                                                                                 2 (3%)                                
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                12 (20%)     18 (31%)     15 (25%)     16 (27%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                           13 (22%)     12 (20%)      9 (15%)     13 (22%)                               
      Necrosis                                                      1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)       1 (2%)                                
   Thymus                                             (60)         (58)         (58)         (56)                                   
      Atrophy                                          1 (2%)                    1 (2%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (59)                                   
      Hyperplasia, Lobular                             1 (2%)                                                                       
      Duct, Cyst                                                                 1 (2%)       2 (3%)                                
   Skin                                               (60)         (59)         (60)         (60)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Parakeratosis                                                 1 (2%)                                                          
      Dermis, Inflammation, Subacute                   2 (3%)       3 (5%)       2 (3%)       3 (5%)                                
      Dermis, Subcutaneous Tissue, Inflammation,                                                                                    
           Subacute                                                 1 (2%)                                                          
      Epidermis, Necrosis                                           1 (2%)                                                          
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                                            1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Subacute                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (59)         (59)         (60)                                   
      Osteopetrosis                                                              1 (2%)                                             
      Cranium, Fibrous Osteodystrophy                               3 (5%)                    1 (2%)                                
      Femur, Fibrous Osteodystrophy                    2 (3%)       2 (3%)       3 (5%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (59)         (60)         (60)                                   
      Compression                                      1 (2%)                    4 (7%)                                             
      Cyst                                             1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Meninges, Infiltration Cellular                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Congestion                                                                 1 (2%)                                             
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Infiltration Cellular, Histiocyte                2 (3%)       2 (3%)                                                          
      Inflammation, Subacute                                                                  1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 3 (5%)       3 (5%)                    1 (2%)                                
      Mediastinum, Inflammation, Subacute                           1 (2%)                                                          
   Nose                                               (60)         (59)         (58)         (60)                                   
      Glands, Cyst                                     1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Lumen, Fungus                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                                                              
      Atrophy                                                       1 (100%)                                                        
      Cataract                                         1 (50%)                                                                      
      Inflammation, Subacute                           1 (50%)                                                                      
      Cornea, Inflammation, Subacute                   1 (50%)                                                                      
   Harderian Gland                                    (3)          (2)                                                              
      Inflammation, Chronic                                         1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Fibrosis                                                      1 (2%)                                                          
      Glomerulosclerosis                               4 (7%)       3 (5%)                    1 (2%)                                
      Infarct                                          2 (3%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                3 (5%)       1 (2%)       4 (7%)       2 (3%)                                
      Inflammation, Subacute                           1 (2%)                                 1 (2%)                                
      Metaplasia, Osseous                                                        2 (3%)       2 (3%)                                
      Mineralization                                  17 (28%)      8 (14%)      8 (13%)      5 (8%)                                
      Polyarteritis                                                 1 (2%)                                                          
      Capsule, Fibrosis                                                                       1 (2%)                                
      Glomerulus, Amyloid Deposition                                                          2 (3%)                                
      Renal Tubule, Casts                              4 (7%)       3 (5%)       2 (3%)       4 (7%)                                
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Dilatation                         1 (2%)                    1 (2%)       4 (7%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Pigmentation                                                              1 (2%)                                
      Renal Tubule, Regeneration                      22 (37%)     14 (24%)     15 (25%)     10 (17%)                               
   Urinary Bladder                                    (60)         (59)         (59)         (60)                                   
      Dilatation                                                    1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            4           10            2                                     
    Natural Death                                      2            9            1            2                                     
    Accidently Killed                                               1                         2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           36           39           44                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (55)         (60)         (58)                                   
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (60)         (53)         (59)         (56)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (58)                                   
      Basophilic Focus                                 1 (2%)       4 (7%)                    5 (9%)                                
      Clear Cell Focus                                 4 (7%)       6 (10%)      5 (8%)       2 (3%)                                
      Cytologic Alterations                                                      1 (2%)                                             
      Eosinophilic Focus                               4 (7%)      17 (28%)      5 (8%)       4 (7%)                                
      Hematopoietic Cell Proliferation                 2 (3%)                                                                       
      Inflammation, Subacute                           1 (2%)                    2 (3%)                                             
      Karyomegaly                                                                             1 (2%)                                
      Mixed Cell Focus                                 7 (12%)      5 (8%)       5 (8%)       3 (5%)                                
      Necrosis                                         4 (7%)       1 (2%)       1 (2%)                                             
      Regeneration                                     1 (2%)                                                                       
      Vacuolization Cytoplasmic                        4 (7%)       3 (5%)       6 (10%)      4 (7%)                                
      Hepatocyte, Hypertrophy, Focal                                                          1 (2%)                                
   Mesentery                                          (3)          (1)          (2)          (4)                                    
      Fat, Inflammation, Granulomatous                                           1 (50%)                                            
      Fat, Necrosis                                    2 (67%)      1 (100%)     1 (50%)      4 (100%)                              
   Pancreas                                           (60)         (58)         (60)         (57)                                   
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Acinus, Atrophy                                  1 (2%)       1 (2%)       2 (3%)                                             
      Acinus, Depletion Secretory                                   1 (2%)       1 (2%)                                             
      Duct, Cyst                                       1 (2%)       1 (2%)       1 (2%)                                             
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
      Acinus, Atrophy                                               1 (2%)                                                          
      Duct, Cyst                                                    1 (2%)                                                          
   Stomach, Forestomach                               (60)         (57)         (60)         (57)                                   
      Cyst                                                                                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                      6 (10%)      4 (7%)                                                          
      Inflammation, Subacute                           1 (2%)       3 (5%)                                                          
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (57)         (60)         (57)                                   
      Cyst                                                          1 (2%)       2 (3%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            2 (3%)                                                                       
   Tooth                                              (2)                       (2)          (2)                                    
      Dysplasia                                                                  1 (50%)      1 (50%)                               
      Inflammation, Chronic                                                      1 (50%)      1 (50%)                               
      Inflammation, Subacute                           2 (100%)                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Cardiomyopathy                                                1 (2%)                                                          
      Fibrosis                                                                   1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Artery, Inflammation, Subacute                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (59)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       2 (3%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
      Hypertrophy                                     15 (25%)     18 (31%)     17 (28%)     17 (29%)                               
      Spindle Cell, Hyperplasia                                                  1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (59)         (60)         (58)                                   
      Hyperplasia                                      1 (2%)       3 (5%)                                                          
   Pituitary Gland                                    (56)         (55)         (60)         (56)                                   
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (60)         (59)                                   
      Follicle, Cyst                                   2 (3%)       1 (2%)                    3 (5%)                                
      Follicle, Degeneration                                                                  1 (2%)                                
      Follicular Cell, Hyperplasia                    15 (25%)     12 (20%)      8 (13%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (2)                                                              
      Dilatation                                       1 (100%)     1 (50%)                                                         
   Epididymis                                         (60)         (59)         (60)         (60)                                   
      Cyst, Multiple                                                             1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)                                
   Preputial Gland                                    (60)         (59)         (60)         (60)                                   
      Abscess                                                       2 (3%)       1 (2%)       2 (3%)                                
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Cyst                                                                       1 (2%)       1 (2%)                                
      Infiltration Cellular, Subacute                                                         1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Subacute                          11 (18%)      2 (3%)      10 (17%)      5 (8%)                                
      Duct, Cyst                                      33 (55%)     37 (63%)     39 (65%)     30 (50%)                               
   Prostate                                           (60)         (59)         (60)         (60)                                   
      Atrophy                                          1 (2%)                                                                       
      Inflammation, Subacute                                                     1 (2%)                                             
      Polyarteritis                                                                           1 (2%)                                
   Seminal Vesicle                                    (60)         (59)         (60)         (60)                                   
      Atrophy                                          1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Dilatation                                       1 (2%)       6 (10%)      1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Hypercellularity                                 2 (3%)       1 (2%)       2 (3%)       3 (5%)                                
   Lymph Node                                         (4)          (1)          (4)          (4)                                    
      Axillary, Hyperplasia, Lymphoid                                            1 (25%)      1 (25%)                               
      Bronchial, Hyperplasia, Lymphoid                                                        2 (50%)                               
      Inguinal, Angiectasis                            1 (25%)                                                                      
      Inguinal, Hyperplasia, Lymphoid                  1 (25%)                   1 (25%)      1 (25%)                               
      Mediastinal, Hyperplasia, Lymphoid                                         1 (25%)                                            
      Pancreatic, Mineralization                       1 (25%)                                                                      
      Renal, Hyperplasia, Lymphoid                                  1 (100%)                                                        
   Lymph Node, Mandibular                             (59)         (57)         (60)         (60)                                   
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)       3 (5%)                                
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (57)                                   
      Angiectasis                                     18 (30%)     21 (36%)     20 (33%)     17 (30%)                               
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)       2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (3%)       2 (3%)       2 (3%)                                             
   Spleen                                             (60)         (59)         (60)         (59)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                          1 (2%)       2 (3%)       3 (5%)       5 (8%)                                
      Hematopoietic Cell Proliferation                12 (20%)      9 (15%)     11 (18%)      6 (10%)                               
      Hyperplasia, Lymphoid                            1 (2%)       3 (5%)                    2 (3%)                                
      Necrosis                                                                   1 (2%)                                             
   Thymus                                             (55)         (56)         (57)         (57)                                   
      Atrophy                                          4 (7%)       1 (2%)       2 (4%)       1 (2%)                                
      Cyst                                             1 (2%)       4 (7%)       1 (2%)       1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (60)         (60)                                   
      Ulcer                                                         1 (2%)                    1 (2%)                                
      Dermis, Inflammation, Chronic                                 1 (2%)                                                          
      Dermis, Inflammation, Subacute                                1 (2%)       1 (2%)       1 (2%)                                
      Pinna, Inflammation, Subacute                                              1 (2%)                                             
      Subcutaneous Tissue, Abscess                     1 (2%)                                                                       
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Cranium, Hyperostosis                                         1 (2%)                                                          
      Femur, Fibrous Osteodystrophy                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Infiltration Cellular, Histiocyte                             1 (2%)       1 (2%)       3 (5%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Inflammation, Subacute                                                                  3 (5%)                                
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (3%)       8 (13%)      8 (13%)      8 (13%)                               
      Bronchiole, Hyperplasia                                                    1 (2%)                                             
   Nose                                               (60)         (59)         (59)         (60)                                   
      Congestion                                                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05155-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Glands, Inflammation, Subacute                                                          1 (2%)                                
      Lumen, Hemorrhage                                                                       1 (2%)                                
      Nasolacrimal Duct, Ectasia                                                 1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Subacute                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)                       (2)          (1)                                    
      Cataract                                         1 (33%)                                                                      
      Retrobulbar, Hemorrhage                          1 (33%)                   2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (58)                                   
      Fibrosis                                         4 (7%)       2 (3%)       3 (5%)       2 (3%)                                
      Glomerulosclerosis                               2 (3%)       5 (8%)       6 (10%)      2 (3%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                          7 (12%)      4 (7%)       5 (8%)       3 (5%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Subacute                                                     2 (3%)                                             
      Metaplasia, Osseous                              1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                  50 (83%)     37 (63%)     28 (47%)     35 (60%)                               
      Cortex, Cyst                                    11 (18%)      6 (10%)      5 (8%)       3 (5%)                                
      Renal Tubule, Casts                              7 (12%)      8 (14%)      7 (12%)      3 (5%)                                
      Renal Tubule, Pigmentation                                    1 (2%)                                                          
      Renal Tubule, Regeneration                      50 (83%)     43 (73%)     42 (70%)     35 (60%)                               
   Urethra                                                         (1)                                                              
      Bulbourethral Gland, Hemorrhage                               1 (100%)                                                        
   Urinary Bladder                                    (60)         (60)         (60)         (58)                                   
      Dilatation                                                                 1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.