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TDMS Study 05155-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        P-NITROBENZOIC ACID


NTP Experiment-Test: 05155-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: DOSED FEED                                                                                                 Time: 19:10:43




       Facility:  Southern Research Institute

       Chemical CAS #:  62-23-7

       Lock Date:  02/19/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            8           12           10                                     
    Natural Death                                      3            5            4            8                                     
    Accidently Killed                                                            1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           36           33           30                                     
  Missing                                                           1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (58)         (57)         (58)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Small, Duodenum                          (59)         (56)         (57)         (56)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Intestine Small, Jejunum                           (59)         (56)         (57)         (56)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (59)         (56)         (57)         (55)                                   
   Liver                                              (60)         (59)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                         5 (8%)       5 (8%)       4 (7%)       6 (10%)                               
      Hepatocellular Carcinoma, Multiple                                         1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           8 (13%)     11 (19%)     15 (25%)      5 (8%)                                
      Hepatocellular Adenoma, Multiple                 3 (5%)       4 (7%)       2 (3%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (3%)       3 (5%)                                             
   Mesentery                                          (5)          (8)          (6)          (7)                                    
      Histiocytic Sarcoma                                           1 (13%)                                                         
      Osteosarcoma, Metastatic, Bone                                                          1 (14%)                               
      Sarcoma                                                                                 1 (14%)                               
   Pancreas                                           (60)         (57)         (59)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (59)         (59)         (59)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
   Stomach, Glandular                                 (59)         (58)         (59)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Tooth                                                                        (1)                                                 
                                                             Page   2                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Histiocytic Sarcoma                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (58)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Adrenal Medulla                                    (59)         (58)         (60)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (59)         (59)         (60)                                   
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (58)         (58)         (58)         (58)                                   
      Pars Distalis, Adenoma                           7 (12%)      6 (10%)      9 (16%)      5 (9%)                                
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      Follicular Cell, Adenoma                                      1 (2%)       2 (3%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (60)         (58)         (59)         (58)                                   
      Cystadenoma                                      1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                           2 (3%)       1 (2%)                                             
      Luteoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Uterus                                             (60)         (59)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (3%)       1 (2%)                                             
      Leiomyoma                                                                               1 (2%)                                
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                                 1 (2%)       2 (3%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Sarcoma Stromal                                  1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Vagina                                             (1)                       (1)                                                 
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (58)         (60)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (3%)                                             
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node                                         (8)          (10)         (15)         (15)                                   
      Axillary, Fibrosarcoma, Metastatic, Skin                                   1 (7%)                                             
      Iliac, Histiocytic Sarcoma                                    1 (10%)      1 (7%)                                             
      Inguinal, Histiocytic Sarcoma                                 1 (10%)      1 (7%)                                             
      Mediastinal, Histiocytic Sarcoma                              1 (10%)                                                         
      Pancreatic, Histiocytic Sarcoma                                            1 (7%)                                             
      Pancreatic, Sarcoma, Metastatic, Mesentery                                              1 (7%)                                
      Renal, Hemangiosarcoma                                                     1 (7%)                                             
      Renal, Histiocytic Sarcoma                                    1 (10%)      1 (7%)                                             
   Lymph Node, Mandibular                             (60)         (59)         (60)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (59)         (59)         (58)         (58)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (59)         (59)         (60)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Thymus                                             (60)         (58)         (58)         (56)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (59)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Skin                                               (60)         (59)         (60)         (60)                                   
      Schwannoma NOS                                                             1 (2%)                                             
      Subcutaneous Tissue, Basal Cell Carcinoma                     1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
      Subcutaneous Tissue, Thymoma Malignant,                                                                                       
          Metastatic, Thymus                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (59)         (59)         (60)                                   
      Femur, Osteosarcoma                                                                     1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (2)          (2)                                    
      Fibrosarcoma                                                               2 (100%)                                           
      Hemangiosarcoma                                  1 (100%)                                                                     
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (100%)                                                        
      Sarcoma, Metastatic, Mesentery                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (59)         (60)         (60)                                   
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Glioma NOS                                                    1 (2%)                                                          
      Meninges, Histiocytic Sarcoma                                 1 (2%)       1 (2%)                                             
      Olfactory Lobe, Histiocytic Sarcoma                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     3 (5%)       5 (8%)       3 (5%)       8 (13%)                               
      Alveolar/Bronchiolar Carcinoma                                4 (7%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                    1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       4 (7%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Mediastinum, Hemangiosarcoma, Metastatic,                                                                                     
           Spleen                                      1 (2%)                                                                       
   Nose                                               (60)         (59)         (58)         (60)                                   
      Glands, Histiocytic Sarcoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (2)                                                              
      Adenoma                                          3 (100%)     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                           2 (3%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Urinary Bladder                                    (60)         (59)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(59)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (3%)       3 (5%)                                             
      Lymphoma Malignant Lymphocytic                   6 (10%)      8 (14%)      7 (12%)      5 (8%)                                
      Lymphoma Malignant Mixed                         3 (5%)       3 (5%)       2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          40          39          33                                       
     Total Primary Neoplasms                           54          63          67          43                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 22          24          27          21                                       
     Total Benign Neoplasms                            29          35          36          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          23          24          17                                       
     Total Malignant Neoplasms                         25          27          30          19                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           2           2                                       
     Total Metastatic Neoplasm                          3           9           4          12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            4           10            2                                     
    Natural Death                                      2            9            1            2                                     
    Accidently Killed                                               1                         2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           36           39           44                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (55)         (60)         (58)                                   
   Intestine Small, Jejunum                           (60)         (53)         (59)         (56)                                   
      Adenocarcinoma                                   3 (5%)       1 (2%)                                                          
   Intestine Small, Ileum                             (60)         (52)         (59)         (56)                                   
   Liver                                              (60)         (60)         (60)         (58)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         6 (10%)     11 (18%)     12 (20%)      4 (7%)                                
      Hepatocellular Carcinoma, Multiple               2 (3%)       4 (7%)       4 (7%)       4 (7%)                                
      Hepatocellular Adenoma                          15 (25%)     11 (18%)      6 (10%)     11 (19%)                               
      Hepatocellular Adenoma, Multiple                 4 (7%)       8 (13%)      8 (13%)      3 (5%)                                
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
   Mesentery                                          (3)          (1)          (2)          (4)                                    
      Sarcoma                                          1 (33%)                                                                      
   Pancreas                                           (60)         (58)         (60)         (57)                                   
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (57)         (60)         (57)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (60)         (57)         (60)         (57)                                   
      Carcinoid Tumor NOS                                           1 (2%)                                                          
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (59)                                   
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (59)         (60)         (59)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (59)         (60)         (58)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (56)         (55)         (60)         (56)                                   
      Pars Distalis, Adenoma                                                                  1 (2%)                                
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (60)         (59)                                   
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (59)         (60)         (60)                                   
   Prostate                                           (60)         (59)         (60)         (60)                                   
   Seminal Vesicle                                    (60)         (59)         (60)         (60)                                   
   Testes                                             (60)         (59)         (60)         (60)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
   Lymph Node                                         (4)          (1)          (4)          (4)                                    
   Lymph Node, Mandibular                             (59)         (57)         (60)         (60)                                   
      Mast Cell Tumor NOS                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (57)                                   
   Spleen                                             (60)         (59)         (60)         (59)                                   
      Hemangiosarcoma                                  4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (60)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Mast Cell Tumor NOS                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (1)                                                 
      Hemangiosarcoma                                  1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     3 (5%)      11 (18%)      8 (13%)      7 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           3 (5%)       2 (3%)       2 (3%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       3 (5%)       2 (3%)       5 (8%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       2 (3%)       6 (10%)      4 (7%)                                
   Nose                                               (60)         (59)         (59)         (60)                                   
      Nasolacrimal Duct, Mast Cell Tumor NOS                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Schwannoma Benign                                                          1 (100%)                                           
   Harderian Gland                                    (1)          (3)          (3)          (1)                                    
      Adenoma                                          1 (100%)     3 (100%)     2 (67%)      1 (100%)                              
      Adenoma, Multiple                                                          1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (58)                                   
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant Lymphocytic                   2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
      Lymphoma Malignant Mixed                                                   1 (2%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05155-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 19:10:43  
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         B6C3F1 MICE MALE                          0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          41          41          31                                       
     Total Primary Neoplasms                           51          64          58          42                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 22          32          26          23                                       
     Total Benign Neoplasms                            29          40          31          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          21          21          14                                       
     Total Malignant Neoplasms                         22          23          24          16                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           2           6           4                                       
     Total Metastatic Neoplasm                          7           2           6           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           3                                                   
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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