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TDMS Study 05155-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                P-NITROBENZOIC ACID                                 DATE: 05/08/95       
EXPERIMENT: 05155 TEST: 04                                                                                     TIME: 19:27:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85217          ROUTE: DOSED FEED                                                                  NTP C#: 61778B       
PATHOLOGIST: DR R. THOMPSON                  HAILEY, JAMESR.                                                   CAS: 62-23-7         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                P-NITROBENZOIC ACID                                 DATE: 05/08/95       
EXPERIMENT: 05155 TEST: 04                                                                                     TIME: 19:27:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85217          ROUTE: DOSED FEED                                                                  NTP C#: 61778B       
PATHOLOGIST: DR R. THOMPSON                  HAILEY, JAMESR.                                                   CAS: 62-23-7         


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                P-NITROBENZOIC ACID                                 DATE: 05/08/95       
EXPERIMENT: 05155 TEST: 04                                                                                     TIME: 19:27:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85217          ROUTE: DOSED FEED                                                                  NTP C#: 61778B       
PATHOLOGIST: DR R. THOMPSON                  HAILEY, JAMESR.                                                   CAS: 62-23-7         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF P-NITROBENZOIC ACID
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Intestine Small: Jejunum      Carcinoma
              Intestine Small: Site Unspecified
                                            Carcinoma
              Lung                          Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              All Organs                    Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Benign Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Harderian Gland               Adenoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              ====================================================================================================
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)  |  1/60 (2%)    1/59 (2%)    2/58 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.6%         2.5%         4.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  1/38 (3%)    0/36 (0%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      685          457 (I)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.416N     P=0.746      P=0.467      P=0.547N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.382N     P=0.730N     P=0.467      P=0.547N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.368N     P=0.756      P=0.492      P=0.547N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.367N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.748      P=0.487      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    3/60 (5%)    1/60 (2%)  |  3/60 (5%)    1/59 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.3%         7.6%         6.6%         2.3%      |   7.2%         2.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    1/36 (3%)    0/39 (0%)    1/44 (2%)  |  0/38 (0%)    1/36 (3%)    0/33 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   720          681          638          729 (T)   |   639          730 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.473N     P=0.284      P=0.303      P=0.744N   |  P=0.061N     P=0.334N     P=0.149N     P=0.171N   |
|INCIDENTAL TUMOR       |  P=0.349      P=0.362      P=0.313      P=0.602    |  P=0.024N*    P=0.227N     P=0.041N*    P=0.045N*  |
|LOGISTIC REGRESSION    |  P=0.538      P=0.294      P=0.394      P=0.762N   |  P=0.050N*    P=0.315N     P=0.125N     P=0.138N   |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.044N*                                         |
|FISHER EXACT           |               P=0.309      P=0.309      P=0.752N   |               P=0.316N     P=0.122N     P=0.122N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/59 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   7.4%         2.8%         0.0%         0.0%      |   0.0%         0.0%         3.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/36 (3%)    0/39 (0%)    0/44 (0%)  |  0/38 (0%)    0/36 (0%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   728          729 (T)      ---          ---       |   ---          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039N*    P=0.338N     P=0.126N     P=0.105N   |  P=0.666        (e)        P=0.472        (e)      |
|INCIDENTAL TUMOR       |  P=0.050N*    P=0.305N     P=0.132N     P=0.188N   |  P=0.666        (e)        P=0.472        (e)      |
|LOGISTIC REGRESSION    |  P=0.042N*    P=0.336N     P=0.131N     P=0.113N   |  P=0.666        (e)        P=0.472        (e)      |
|COCHRAN-ARMITAGE       |  P=0.044N*                                         |  P=0.695                                           |
|FISHER EXACT           |               P=0.309N     P=0.122N     P=0.122N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/59 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   7.4%         2.8%         0.0%         0.0%      |   0.0%         0.0%         3.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/36 (3%)    0/39 (0%)    0/44 (0%)  |  0/38 (0%)    0/36 (0%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   728          729 (T)      ---          ---       |   ---          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039N*    P=0.338N     P=0.126N     P=0.105N   |  P=0.666        (e)        P=0.472        (e)      |
|INCIDENTAL TUMOR       |  P=0.050N*    P=0.305N     P=0.132N     P=0.188N   |  P=0.666        (e)        P=0.472        (e)      |
|LOGISTIC REGRESSION    |  P=0.042N*    P=0.336N     P=0.131N     P=0.113N   |  P=0.666        (e)        P=0.472        (e)      |
|COCHRAN-ARMITAGE       |  P=0.044N*                                         |  P=0.695                                           |
|FISHER EXACT           |               P=0.309N     P=0.122N     P=0.122N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/60 (32%)  19/60 (32%)  14/60 (23%)  14/58 (24%) | 11/60 (18%)  15/59 (25%)  17/60 (28%)   6/60 (10%) |
|ADJUSTED (b)           |  38.6%        43.2%        31.5%        31.1%      |  27.2%        34.3%        38.4%        17.1%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   2/10 (20%)   2/10 (20%)   0/10 (0%)  |  0/10 (0%)    2/10 (20%)   4/10 (40%)   1/10 (10%) |
|TERMINAL (d)           | 10/39 (26%)  13/36 (36%)  10/39 (26%)  13/44 (30%) |  9/38 (24%)   9/36 (25%)   9/33 (27%)   4/30 (13%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      442          456 (I)      667       |   589          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.078N     P=0.496      P=0.230N     P=0.150N   |  P=0.236N     P=0.219      P=0.089      P=0.282N   |
|INCIDENTAL TUMOR       |  P=0.202N     P=0.546      P=0.217N     P=0.446N   |  P=0.121N     P=0.286      P=0.137      P=0.179N   |
|LOGISTIC REGRESSION    |  P=0.208N     P=0.561N     P=0.181N     P=0.389N   |  P=0.123N     P=0.231      P=0.133      P=0.202N   |
|COCHRAN-ARMITAGE       |  P=0.156N                                          |  P=0.099N                                          |
|FISHER EXACT           |               P=0.578N     P=0.207N     P=0.240N   |               P=0.238      P=0.140      P=0.148N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)  15/60 (25%)  16/60 (27%)   8/58 (14%) |  5/60 (8%)    5/59 (8%)    5/60 (8%)    7/60 (12%) |
|ADJUSTED (b)           |  19.1%        32.0%        35.7%        17.4%      |  11.4%        13.0%        15.2%        21.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    2/10 (20%)   0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  6/39 (15%)   6/36 (17%)  11/39 (28%)   6/44 (14%) |  3/38 (8%)    3/36 (8%)    5/33 (15%)   5/30 (17%) |
|FIRST INCIDENCE (DAYS) |   597          456 (I)      496          582       |   457 (I)      685          730 (T)      616       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.313N     P=0.074      P=0.060      P=0.531N   |  P=0.179      P=0.596      P=0.556      P=0.262    |
|INCIDENTAL TUMOR       |  P=0.476      P=0.119      P=0.063      P=0.527    |  P=0.248      P=0.625      P=0.531      P=0.354    |
|LOGISTIC REGRESSION    |  P=0.466      P=0.085      P=0.057      P=0.421    |  P=0.239      P=0.619      P=0.620      P=0.339    |
|COCHRAN-ARMITAGE       |  P=0.440N                                          |  P=0.302                                           |
|FISHER EXACT           |               P=0.082      P=0.054      P=0.577    |               P=0.618      P=0.628N     P=0.381    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/60 (40%)  30/60 (50%)  25/60 (42%)  19/58 (33%) | 16/60 (27%)  18/59 (31%)  19/60 (32%)  12/60 (20%) |
|ADJUSTED (b)           |  49.2%        58.9%        52.3%        41.3%      |  37.2%        40.8%        43.6%        33.5%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   4/10 (40%)   2/10 (20%)   0/10 (0%)  |  1/10 (10%)   2/10 (20%)   4/10 (40%)   1/10 (10%) |
|TERMINAL (d)           | 15/39 (38%)  16/36 (44%)  17/39 (44%)  17/44 (39%) | 12/38 (32%)  11/36 (31%)  11/33 (33%)   8/30 (27%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      442          456 (I)      582       |   457 (I)      457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055N     P=0.150      P=0.492      P=0.144N   |  P=0.424N     P=0.364      P=0.230      P=0.483N   |
|INCIDENTAL TUMOR       |  P=0.230N     P=0.181      P=0.510      P=0.404N   |  P=0.236N     P=0.443      P=0.297      P=0.305N   |
|LOGISTIC REGRESSION    |  P=0.232N     P=0.189      P=0.553      P=0.445N   |  P=0.243N     P=0.393      P=0.332      P=0.339N   |
|COCHRAN-ARMITAGE       |  P=0.129N                                          |  P=0.190N                                          |
|FISHER EXACT           |               P=0.179      P=0.500      P=0.266N   |               P=0.397      P=0.344      P=0.259N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/60 (40%)  30/60 (50%)  25/60 (42%)  19/58 (33%) | 16/60 (27%)  18/59 (31%)  19/60 (32%)  12/60 (20%) |
|ADJUSTED (b)           |  49.2%        58.9%        52.3%        41.3%      |  37.2%        40.8%        43.6%        33.5%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   4/10 (40%)   2/10 (20%)   0/10 (0%)  |  1/10 (10%)   2/10 (20%)   4/10 (40%)   1/10 (10%) |
|TERMINAL (d)           | 15/39 (38%)  16/36 (44%)  17/39 (44%)  17/44 (39%) | 12/38 (32%)  11/36 (31%)  11/33 (33%)   8/30 (27%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      442          456 (I)      582       |   457 (I)      457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055N     P=0.150      P=0.492      P=0.144N   |  P=0.424N     P=0.364      P=0.230      P=0.483N   |
|INCIDENTAL TUMOR       |  P=0.230N     P=0.181      P=0.510      P=0.404N   |  P=0.236N     P=0.443      P=0.297      P=0.305N   |
|LOGISTIC REGRESSION    |  P=0.232N     P=0.189      P=0.553      P=0.445N   |  P=0.243N     P=0.393      P=0.332      P=0.339N   |
|COCHRAN-ARMITAGE       |  P=0.129N                                          |  P=0.190N                                          |
|FISHER EXACT           |               P=0.179      P=0.500      P=0.266N   |               P=0.397      P=0.344      P=0.259N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)  13/60 (22%)  10/60 (17%)  10/60 (17%) |  3/60 (5%)    5/59 (8%)    3/60 (5%)    8/60 (13%) |
|ADJUSTED (b)           |  15.4%        30.4%        23.2%        21.9%      |   7.5%        12.9%         8.7%        24.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   2/10 (20%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  6/39 (15%)   8/36 (22%)   8/39 (21%)   9/44 (20%) |  2/38 (5%)    3/36 (8%)    2/33 (6%)    6/30 (20%) |
|FIRST INCIDENCE (DAYS) |   729 (T)      456 (I)      456 (I)      456 (I)   |   689          685          715          570       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.451      P=0.052      P=0.207      P=0.283    |  P=0.035 *    P=0.324      P=0.599      P=0.050 *  |
|INCIDENTAL TUMOR       |  P=0.364      P=0.062      P=0.207      P=0.283    |  P=0.060      P=0.406      P=0.619N     P=0.088    |
|LOGISTIC REGRESSION    |  P=0.306      P=0.059      P=0.204      P=0.194    |  P=0.046 *    P=0.336      P=0.637      P=0.064    |
|COCHRAN-ARMITAGE       |  P=0.329                                           |  P=0.080                                           |
|FISHER EXACT           |               P=0.066      P=0.211      P=0.211    |               P=0.349      P=0.660N     P=0.102    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    2/60 (3%)    5/60 (8%)  |  0/60 (0%)    5/59 (8%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   2.6%         8.0%         5.1%        11.4%      |   0.0%        13.9%         2.9%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    2/36 (6%)    2/39 (5%)    5/44 (11%) |  0/38 (0%)    5/36 (14%)   0/33 (0%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      725          729 (T)      729 (T)   |   ---          730 (T)      720          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.116      P=0.279      P=0.500      P=0.133    |  P=0.572N     P=0.029 *    P=0.468      P=0.453    |
|INCIDENTAL TUMOR       |  P=0.084      P=0.307      P=0.500      P=0.133    |  P=0.541N     P=0.029 *    P=0.617      P=0.453    |
|LOGISTIC REGRESSION    |  P=0.095      P=0.279      P=0.500      P=0.133    |  P=0.568N     P=0.029 *    P=0.489      P=0.453    |
|COCHRAN-ARMITAGE       |  P=0.079                                           |  P=0.472N                                          |
|FISHER EXACT           |               P=0.309      P=0.500      P=0.103    |               P=0.027 *    P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)  15/60 (25%)  12/60 (20%)  14/60 (23%) |  3/60 (5%)   10/59 (17%)   4/60 (7%)    9/60 (15%) |
|ADJUSTED (b)           |  17.9%        35.4%        28.2%        30.8%      |   7.5%        26.1%        11.3%        27.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   2/10 (20%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  7/39 (18%)  10/36 (28%)  10/39 (26%)  13/44 (30%) |  2/38 (5%)    8/36 (22%)   2/33 (6%)    7/30 (23%) |
|FIRST INCIDENCE (DAYS) |   729 (T)      456 (I)      456 (I)      456 (I)   |   689          685          715          570       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.240      P=0.035 *    P=0.154      P=0.118    |  P=0.063      P=0.031 *    P=0.428      P=0.027 *  |
|INCIDENTAL TUMOR       |  P=0.177      P=0.043 *    P=0.154      P=0.118    |  P=0.102      P=0.042 *    P=0.592      P=0.050 *  |
|LOGISTIC REGRESSION    |  P=0.120      P=0.042 *    P=0.150      P=0.064    |  P=0.081      P=0.030 *    P=0.468      P=0.035 *  |
|COCHRAN-ARMITAGE       |  P=0.138                                           |  P=0.149                                           |
|FISHER EXACT           |               P=0.049 *    P=0.159      P=0.074    |               P=0.035 *    P=0.500      P=0.063    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/60 (2%)    2/58 (3%)    1/59 (2%)    1/58 (2%)  |
|ADJUSTED (b)           |                                                    |   2.6%         5.7%         3.0%         2.9%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/38 (3%)    2/35 (6%)    1/33 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   730 (T)      730 (T)      730 (T)      678       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.623      P=0.471      P=0.730      P=0.703    |
|INCIDENTAL TUMOR       |                                                    |  P=0.594N     P=0.471      P=0.730      P=0.760N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.601N     P=0.471      P=0.730      P=0.726    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.539N                                          |
|FISHER EXACT           |                                                    |               P=0.487      P=0.748      P=0.744    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/55 (0%)    0/60 (0%)    1/56 (2%)  |  7/58 (12%)   6/58 (10%)   9/58 (16%)   5/58 (9%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.3%      |  18.3%        16.7%        24.1%        17.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/36 (0%)    0/35 (0%)    0/39 (0%)    1/43 (2%)  |  6/37 (16%)   6/36 (17%)   6/33 (18%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          729 (T)   |   728          730 (T)      589          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.225        (e)          (e)        P=0.535    |  P=0.517      P=0.526N     P=0.309      P=0.583N   |
|INCIDENTAL TUMOR       |  P=0.225        (e)          (e)        P=0.535    |  P=0.516N     P=0.509N     P=0.437      P=0.545N   |
|LOGISTIC REGRESSION    |  P=0.225        (e)          (e)        P=0.535    |  P=0.543N     P=0.564N     P=0.371      P=0.615N   |
|COCHRAN-ARMITAGE       |  P=0.198                                           |  P=0.378N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |               P=0.500N     P=0.394      P=0.381N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/55 (0%)    0/60 (0%)    1/56 (2%)  |  8/58 (14%)   6/58 (10%)   9/58 (16%)   5/58 (9%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.3%      |  20.2%        16.7%        24.1%        17.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/9 (0%)     0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/36 (0%)    0/35 (0%)    0/39 (0%)    1/43 (2%)  |  6/37 (16%)   6/36 (17%)   6/33 (18%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          729 (T)   |   689          730 (T)      589          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.225        (e)          (e)        P=0.535    |  P=0.504N     P=0.418N     P=0.406      P=0.474N   |
|INCIDENTAL TUMOR       |  P=0.225        (e)          (e)        P=0.535    |  P=0.407N     P=0.384N     P=0.575      P=0.403N   |
|LOGISTIC REGRESSION    |  P=0.225        (e)          (e)        P=0.535    |  P=0.441N     P=0.429N     P=0.481      P=0.453N   |
|COCHRAN-ARMITAGE       |  P=0.198                                           |  P=0.293N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |               P=0.388N     P=0.500      P=0.279N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skeletal Muscle                                                                                                                  |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/59 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         5.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  0/38 (0%)    0/36 (0%)    0/33 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          707          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.547        (e)        P=0.214        (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.657        (e)        P=0.371        (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.568        (e)        P=0.228        (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.596                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)        P=0.248        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  1/60 (2%)    1/59 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.6%         2.8%         4.6%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  1/38 (3%)    1/36 (3%)    0/33 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      730 (T)      629          665       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.531      P=0.750      P=0.481      P=0.714    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.594N     P=0.750      P=0.609      P=0.752N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.572      P=0.750      P=0.497      P=0.741    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.592                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.748      P=0.500      P=0.752N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  1/60 (2%)    1/59 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.6%         2.8%         4.6%         2.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  1/38 (3%)    1/36 (3%)    0/33 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      730 (T)      629          665       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.531      P=0.750      P=0.481      P=0.714    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.594N     P=0.750      P=0.609      P=0.752N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.572      P=0.750      P=0.497      P=0.741    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.592                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.748      P=0.500      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    1/59 (2%)    1/60 (2%)    1/59 (2%)  |  1/60 (2%)    1/59 (2%)    1/59 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  10.3%         2.8%         2.4%         2.3%      |   2.4%         2.5%         2.6%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/39 (10%)   1/36 (3%)    0/39 (0%)    1/44 (2%)  |  0/38 (0%)    0/36 (0%)    0/33 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      695          729 (T)   |   693          685          707          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.113N     P=0.204N     P=0.185N     P=0.145N   |  P=0.357N     P=0.741      P=0.741      P=0.542N   |
|INCIDENTAL TUMOR       |  P=0.139N     P=0.204N     P=0.191N     P=0.145N   |  P=0.236N     P=0.692N     P=0.629N     P=0.433N   |
|LOGISTIC REGRESSION    |  P=0.132N     P=0.204N     P=0.187N     P=0.145N   |  P=0.330N     P=0.758      P=0.756      P=0.518N   |
|COCHRAN-ARMITAGE       |  P=0.137N                                          |  P=0.311N                                          |
|FISHER EXACT           |               P=0.187N     P=0.182N     P=0.187N   |               P=0.748      P=0.748      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  1/60 (2%)    2/59 (3%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.6%         0.0%      |   2.6%         5.2%         6.1%         3.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/36 (0%)    1/39 (3%)    0/44 (0%)  |  1/38 (3%)    1/36 (3%)    2/33 (6%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      ---       |   730 (T)      685          730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.709        (e)        P=0.500        (e)      |  P=0.582      P=0.479      P=0.451      P=0.708    |
|INCIDENTAL TUMOR       |  P=0.709        (e)        P=0.500        (e)      |  P=0.612      P=0.526      P=0.451      P=0.708    |
|LOGISTIC REGRESSION    |  P=0.709        (e)        P=0.500        (e)      |  P=0.605      P=0.487      P=0.451      P=0.708    |
|COCHRAN-ARMITAGE       |  P=0.694                                           |  P=0.553N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.494      P=0.500      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/59 (2%)    0/60 (0%)    0/59 (0%)  |  0/60 (0%)    1/59 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.2%         2.5%         0.0%         0.0%      |   0.0%         2.8%         5.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  0/38 (0%)    1/36 (3%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      701          ---          ---       |   ---          730 (T)      689          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.098N     P=0.518N     P=0.240N     P=0.227N   |  P=0.637      P=0.489      P=0.214        (e)      |
|INCIDENTAL TUMOR       |  P=0.126N     P=0.480N     P=0.240N     P=0.227N   |  P=0.637N     P=0.489      P=0.285        (e)      |
|LOGISTIC REGRESSION    |  P=0.098N     P=0.496N     P=0.235N     P=0.216N   |  P=0.654N     P=0.489      P=0.229        (e)      |
|COCHRAN-ARMITAGE       |  P=0.102N                                          |  P=0.614N                                          |
|FISHER EXACT           |               P=0.506N     P=0.248N     P=0.252N   |               P=0.496      P=0.248        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/59 (2%)    0/60 (0%)    0/59 (0%)  |  1/60 (2%)    1/59 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.2%         2.5%         0.0%         0.0%      |   2.6%         2.8%         5.5%         2.7%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  1/38 (3%)    1/36 (3%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      701          ---          ---       |   730 (T)      730 (T)      689          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.098N     P=0.518N     P=0.240N     P=0.227N   |  P=0.520      P=0.750      P=0.456      P=0.717    |
|INCIDENTAL TUMOR       |  P=0.126N     P=0.480N     P=0.240N     P=0.227N   |  P=0.581      P=0.750      P=0.534      P=0.752N   |
|LOGISTIC REGRESSION    |  P=0.098N     P=0.496N     P=0.235N     P=0.216N   |  P=0.555      P=0.750      P=0.483      P=0.745    |
|COCHRAN-ARMITAGE       |  P=0.102N                                          |  P=0.592                                           |
|FISHER EXACT           |               P=0.506N     P=0.248N     P=0.252N   |               P=0.748      P=0.500      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/60 (0%)    1/59 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         2.8%         6.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/38 (0%)    1/36 (3%)    2/33 (6%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.635      P=0.489      P=0.208        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.635      P=0.489      P=0.208        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.635      P=0.489      P=0.208        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.614N                                          |
|FISHER EXACT           |                                                    |               P=0.496      P=0.248        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/60 (2%)    1/59 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   2.6%         2.8%         6.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/38 (3%)    1/36 (3%)    2/33 (6%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   730 (T)      730 (T)      730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.433N     P=0.750      P=0.451      P=0.547N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.433N     P=0.750      P=0.451      P=0.547N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.433N     P=0.750      P=0.451      P=0.547N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.365N                                          |
|FISHER EXACT           |                                                    |               P=0.748      P=0.500      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   2/60 (3%)    2/60 (3%)    1/60 (2%)  |  4/60 (7%)    1/59 (2%)    3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |  14.9%         5.6%         4.9%         2.3%      |  10.1%         2.5%         7.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  5/39 (13%)   2/36 (6%)    1/39 (3%)    1/44 (2%)  |  3/38 (8%)    0/36 (0%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   728          729 (T)      695          729 (T)   |   693          685          457 (I)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.032N*    P=0.164N     P=0.142N     P=0.044N*  |  P=0.104N     P=0.204N     P=0.556N     P=0.098N   |
|INCIDENTAL TUMOR       |  P=0.048N*    P=0.148N     P=0.148N     P=0.071N   |  P=0.069N     P=0.149N     P=0.455N     P=0.076N   |
|LOGISTIC REGRESSION    |  P=0.040N*    P=0.162N     P=0.144N     P=0.049N*  |  P=0.080N     P=0.190N     P=0.509N     P=0.085N   |
|COCHRAN-ARMITAGE       |  P=0.043N*                                         |  P=0.072N                                          |
|FISHER EXACT           |               P=0.136N     P=0.136N     P=0.057N   |               P=0.187N     P=0.500N     P=0.059N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   3/60 (5%)    2/60 (3%)    1/60 (2%)  |  4/60 (7%)    1/59 (2%)    3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |  14.9%         7.8%         4.9%         2.3%      |  10.1%         2.5%         7.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  5/39 (13%)   2/36 (6%)    1/39 (3%)    1/44 (2%)  |  3/38 (8%)    0/36 (0%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   728          695          695          729 (T)   |   693          685          457 (I)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.028N*    P=0.284N     P=0.142N     P=0.044N*  |  P=0.104N     P=0.204N     P=0.556N     P=0.098N   |
|INCIDENTAL TUMOR       |  P=0.050N*    P=0.247N     P=0.148N     P=0.071N   |  P=0.069N     P=0.149N     P=0.455N     P=0.076N   |
|LOGISTIC REGRESSION    |  P=0.034N*    P=0.263N     P=0.144N     P=0.049N*  |  P=0.080N     P=0.190N     P=0.509N     P=0.085N   |
|COCHRAN-ARMITAGE       |  P=0.036N*                                         |  P=0.072N                                          |
|FISHER EXACT           |               P=0.245N     P=0.136N     P=0.057N   |               P=0.187N     P=0.500N     P=0.059N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  1/60 (2%)    2/59 (3%)    3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.6%         4.2%         7.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/36 (0%)    0/39 (0%)    0/44 (0%)  |  1/38 (3%)    0/36 (0%)    1/33 (3%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   730 (T)      526          624          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.388N     P=0.496      P=0.281      P=0.547N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.241N     P=0.480      P=0.378      P=0.547N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.225N     P=0.564      P=0.298      P=0.547N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.336N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.494      P=0.309      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    3/60 (5%)    2/60 (3%)  | 10/60 (17%)  13/59 (22%)  11/60 (18%)   7/60 (12%) |
|ADJUSTED (b)           |   5.1%         2.8%         6.7%         4.5%      |  23.7%        33.4%        27.5%        20.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/36 (3%)    2/39 (5%)    2/44 (5%)  |  7/38 (18%)  11/36 (31%)   6/33 (18%)   3/30 (10%) |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      451          729 (T)   |   423          526          569          700       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.554      P=0.528N     P=0.502      P=0.651N   |  P=0.367N     P=0.274      P=0.390      P=0.495N   |
|INCIDENTAL TUMOR       |  P=0.518      P=0.528N     P=0.500      P=0.651N   |  P=0.178N     P=0.285      P=0.576      P=0.291N   |
|LOGISTIC REGRESSION    |  P=0.491      P=0.528N     P=0.499      P=0.651N   |  P=0.254N     P=0.296      P=0.477      P=0.395N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.181N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.691N   |               P=0.306      P=0.500      P=0.301N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    3/60 (5%)    2/60 (3%)  |  9/60 (15%)  11/59 (19%)   9/60 (15%)   7/60 (12%) |
|ADJUSTED (b)           |   5.1%         2.8%         6.7%         4.5%      |  21.3%        30.6%        24.0%        20.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    1/36 (3%)    2/39 (5%)    2/44 (5%)  |  6/38 (16%)  11/36 (31%)   6/33 (18%)   3/30 (10%) |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      451          729 (T)   |   423          730 (T)      569          700       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.554      P=0.528N     P=0.502      P=0.651N   |  P=0.472N     P=0.347      P=0.487      P=0.586N   |
|INCIDENTAL TUMOR       |  P=0.518      P=0.528N     P=0.500      P=0.651N   |  P=0.315N     P=0.370      P=0.571N     P=0.377N   |
|LOGISTIC REGRESSION    |  P=0.491      P=0.528N     P=0.499      P=0.651N   |  P=0.375N     P=0.288      P=0.580      P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.266N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.691N   |               P=0.387      P=0.601N     P=0.395N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/60 (37%)  32/60 (53%)  26/60 (43%)  23/60 (38%) | 22/60 (37%)  24/59 (41%)  27/60 (45%)  21/60 (35%) |
|ADJUSTED (b)           |  44.9%        64.6%        51.7%        49.8%      |  49.8%        54.9%        59.5%        57.3%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   3/10 (30%)   6/10 (60%)   1/10 (10%) |  0/10 (0%)    2/10 (20%)   4/10 (40%)   1/10 (10%) |
|TERMINAL (d)           | 13/39 (33%)  19/36 (53%)  16/39 (41%)  21/44 (48%) | 16/38 (42%)  17/36 (47%)  16/33 (48%)  15/30 (50%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      442          456 (I)      456 (I)   |   589          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.229N     P=0.046 *    P=0.298      P=0.499N   |  P=0.273      P=0.348      P=0.126      P=0.309    |
|INCIDENTAL TUMOR       |  P=0.474      P=0.044 *    P=0.298      P=0.298    |  P=0.532N     P=0.488      P=0.271      P=0.553N   |
|LOGISTIC REGRESSION    |  P=0.517      P=0.047 *    P=0.288      P=0.302    |  P=0.483      P=0.382      P=0.201      P=0.465    |
|COCHRAN-ARMITAGE       |  P=0.387N                                          |  P=0.436N                                          |
|FISHER EXACT           |               P=0.049 *    P=0.288      P=0.500    |               P=0.397      P=0.229      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/60 (30%)  21/60 (35%)  21/60 (35%)  14/60 (23%) | 24/60 (40%)  23/59 (39%)  24/60 (40%)  17/60 (28%) |
|ADJUSTED (b)           |  40.4%        44.9%        45.8%        30.4%      |  52.6%        54.3%        52.7%        43.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    2/10 (20%)   0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 13/39 (33%)  11/36 (31%)  15/39 (38%)  12/44 (27%) | 17/38 (45%)  17/36 (47%)  12/33 (36%)   8/30 (27%) |
|FIRST INCIDENCE (DAYS) |   419          456 (I)      451          582       |   423          526          457 (I)      471       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.111N     P=0.280      P=0.351      P=0.181N   |  P=0.365N     P=0.552      P=0.390      P=0.378N   |
|INCIDENTAL TUMOR       |  P=0.348N     P=0.415      P=0.363      P=0.410N   |  P=0.077N     P=0.505N     P=0.444N     P=0.102N   |
|LOGISTIC REGRESSION    |  P=0.293N     P=0.321      P=0.336      P=0.291N   |  P=0.100N     P=0.538N     P=0.542      P=0.195N   |
|COCHRAN-ARMITAGE       |  P=0.185N                                          |  P=0.098N                                          |
|FISHER EXACT           |               P=0.348      P=0.348      P=0.268N   |               P=0.530N     P=0.574N     P=0.124N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 04                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 35/60 (58%)  41/60 (68%)  41/60 (68%)  31/60 (52%) | 37/60 (62%)  40/59 (68%)  39/60 (65%)  33/60 (55%) |
|ADJUSTED (b)           |  69.5%        75.7%        75.4%        65.8%      |  75.3%        83.1%        74.6%        76.5%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   5/10 (50%)   6/10 (60%)   1/10 (10%) |  1/10 (10%)   2/10 (20%)   4/10 (40%)   1/10 (10%) |
|TERMINAL (d)           | 24/39 (62%)  23/36 (64%)  26/39 (67%)  28/44 (64%) | 26/38 (68%)  28/36 (78%)  20/33 (61%)  20/30 (67%) |
|FIRST INCIDENCE (DAYS) |   419          442          451          456 (I)   |   423          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.069N     P=0.137      P=0.212      P=0.145N   |  P=0.367      P=0.261      P=0.227      P=0.357    |
|INCIDENTAL TUMOR       |  P=0.380N     P=0.149      P=0.180      P=0.489N   |  P=0.154N     P=0.380      P=0.557      P=0.268N   |
|LOGISTIC REGRESSION    |  P=0.349N     P=0.159      P=0.168      P=0.356N   |  P=0.185N     P=0.370      P=0.532      P=0.485N   |
|COCHRAN-ARMITAGE       |  P=0.162N                                          |  P=0.179N                                          |
|FISHER EXACT           |               P=0.172      P=0.172      P=0.291N   |               P=0.306      P=0.425      P=0.289N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.