Share This:
https://ntp.niehs.nih.gov/go/2352

TDMS Study 05155-04 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 05/08/95   
EXP: 05155                   P-NITROBENZOIC ACID               TIME: 19:27:50   
TEST: 04              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 61778B   
CONT: N01-ES-85217                                             CAS: 62-23-7     
PATHOLOGIST: DR R. THOMPSON                  HAILEY, JAMESR.                    
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 05/08/95  
EXP: 05155                   P-NITROBENZOIC ACID               TIME: 19:27:50  
TEST: 04              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 61778B  
CONT: N01-ES-85217                                             CAS: 62-23-7    
PATHOLOGIST: DR R. THOMPSON                  HAILEY, JAMESR.                   

                                P-NITROBENZOIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      419   532   537   597   660   666   675   720   720   728                 |
 |      728                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.125%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 11   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      442   537   575   601   665   675   681   695   700   701                 |
 |      720   725   728                                                           |
 |  CENSORED DEATHS                                                               |
 |      7     456   456   456   456   456   456   456   456   456                 |
 |      456                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.25%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      451   496   522   588   638   675   681   681   693   695                 |
 |      703                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                                P-NITROBENZOIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.5%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 4      CENSORED DEATHS 12   TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      188   378   582   667                                                     |
 |  CENSORED DEATHS                                                               |
 |      7     7     456   456   456   456   456   456   456   456                 |
 |      456   456                                                                 |
 |                                                                                |
 ==================================================================================

                                P-NITROBENZOIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0%       |   100.0 100.0 100.0 100.0  98.3  98.3  94.3  92.3  90.3  78.3      |
 |           |                                                                    |
 |           |                                                                    |
 |0.125%     |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  92.2  90.1  73.7      |
 |           |                                                                    |
 |           |                                                                    |
 |0.25%      |   100.0 100.0 100.0 100.0 100.0  98.3  94.3  92.3  90.3  78.3      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5%       |   100.0 100.0  98.3  98.3  96.6  96.6  96.6  94.5  94.5  92.4      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0.0%         0.125%       0.25%        0.5%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.3%        73.7%        78.3%        92.4%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.077N     P=0.764      P=1.000      P=0.125N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       634.7        649.6        620.3        453.8    |
 |NATURAL DEATHS (C)      |       (30.6)       (24.0)       (27.5)       ( 107)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       666.2        654.3        663.6        641.1    |
 |(STANDARD ERROR)        |       (14.2)       (17.7)       (14.1)       (22.3)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                P-NITROBENZOIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 12     CENSORED DEATHS 10   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      364   423   533   533   589   616   639   689   693   723                 |
 |      728   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.125%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 11   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      400   526   550   594   598   620   657   678   681   685                 |
 |      685   701   701                                                           |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |      526                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.25%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 11   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      480   490   569   589   624   629   638   651   678   680                 |
 |      689   707   707   715   720   720                                         |
 |  CENSORED DEATHS                                                               |
 |      7     457   457   457   457   457   457   457   457   457                 |
 |      457                                                                       |
 |                                                                                |
 ==================================================================================

                                P-NITROBENZOIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.5%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 12   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      457   471   490   519   565   570   584   616   630   636                 |
 |      637   646   665   678   700   709   712   715                             |
 |  CENSORED DEATHS                                                               |
 |      7     7     457   457   457   457   457   457   457   457                 |
 |      457   457                                                                 |
 |                                                                                |
 ==================================================================================

                                P-NITROBENZOIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0.0%       |   100.0 100.0 100.0  98.3  96.7  96.7  92.6  90.6  86.6  76.5      |
 |           |                                                                    |
 |           |                                                                    |
 |0.125%     |   100.0 100.0 100.0 100.0  98.3  98.3  96.3  90.2  86.1  73.8      |
 |           |                                                                    |
 |           |                                                                    |
 |0.25%      |   100.0 100.0 100.0 100.0 100.0  98.0  95.9  91.8  83.7  67.3      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5%       |   100.0 100.0 100.0 100.0 100.0  96.2  92.0  85.7  73.2  62.7      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0.0%         0.125%       0.25%        0.5%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       76.5%        73.8%        67.3%        62.7%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.118      P=0.925      P=0.465      P=0.194  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       604.8        621.2        642.9        611.1    |
 |NATURAL DEATHS (C)      |       (35.0)       (24.5)       (19.3)       (19.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       659.5        657.5        649.2        624.7    |
 |(STANDARD ERROR)        |       (15.0)       (14.3)       (17.5)       (20.6)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                        P-NITROBENZOIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0%             = 1
                                                        0.125%           = 2
                                                        0.25%            = 3
                                                        0.5%             = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                             4                                   1   2 3
      |                               4                            4      1   2 3     3     12
      |
      |                                                            4                  3    311     24
P  95 +                                                                                             4             4
E     |                                                                                    3 1     23  1
R     |                                                                                             3  1     3   14         4
C     |
E  90 +                                                                                                      3   112
N     |                                                                                                           113
T     |                                                                                                            22
      |                                                                                                            12 2  1
S  85 +
U     |                                                                                                             33
R     |                                                                                                              322 11
V     |
I  80 +                                                                                                               32 2
V     |                                                                                                                3  1 1
A     |                                                                                                                  22
L     |
   75 +
      |                                                                                                                   2 2
      |
      |
   70 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.

                                                        P-NITROBENZOIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0.0%             = 1
                                                        0.125%           = 2
                                                        0.25%            = 3
                                                        0.5%             = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                        1      2        4  3
      |                                                          1      2  1     4 4        2
      |                                                                             33
      |                                                                    1       4 3      21 2  3
   95 +
      |                                                                              4     4   2  3   2
      |                                                                                    4 1   4    12
      |                                                                                               1  1 3
P  90 +                                                                                          44    2  2
E     |                                                                                                  12  1 2
R     |                                                                                           4 4      3 3
C     |                                                                                             4    4   132   2 1
E  85 +
N     |                                                                                                  4 4  3    22
T     |                                                                                                              1    1
      |                                                                                                    44      33
S  80 +                                                                                                             33
U     |
R     |                                                                                                     4 4     23 2
V     |                                                                                                                   1 1
I  75 +                                                                                                       4  4
V     |                                                                                                          4 4   2 3  2
A     |
L     |                                                                                                            4  4
   70 +
      |                                                                                                               4 4
      |                                                                                                                  3  3
      |
   65 +                                                                                                                 44
      |
      |                                                                                                                  4  4
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.