National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2354

TDMS Study 05155-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        P-NITROBENZOIC ACID


NTP Experiment-Test: 05155-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: DOSED FEED                                                                                                 Time: 16:48:31




       Facility:  Southern Research Institute

       Chemical CAS #:  62-23-7

       Lock Date:  02/15/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           23           27           26                                     
    Natural Death                                      2            4            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           23           21           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (58)         (60)         (60)                                   
      Parasite Metazoan                                1 (2%)                    1 (2%)                                             
   Intestine Large, Rectum                            (60)         (58)         (60)         (58)                                   
      Parasite Metazoan                                             7 (12%)      2 (3%)       4 (7%)                                
   Intestine Large, Cecum                             (60)         (57)         (60)         (59)                                   
      Parasite Metazoan                                             1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       2 (3%)                    2 (3%)                                
      Basophilic Focus                                40 (67%)     43 (72%)     50 (83%)     55 (92%)                               
      Clear Cell Focus                                 4 (7%)       7 (12%)      7 (12%)     12 (20%)                               
      Eosinophilic Focus                               4 (7%)       4 (7%)                    1 (2%)                                
      Fatty Change                                    14 (23%)     14 (23%)      7 (12%)      7 (12%)                               
      Fibrosis, Focal                                  1 (2%)                    2 (3%)                                             
      Focal Cellular Change                            1 (2%)       1 (2%)       2 (3%)                                             
      Hematopoietic Cell Proliferation                              2 (3%)       2 (3%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                       8 (13%)      6 (10%)     12 (20%)     16 (27%)                               
      Hepatodiaphragmatic Nodule, Multiple                          2 (3%)       2 (3%)       3 (5%)                                
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Hyperplasia, Multifocal                          9 (15%)     10 (17%)      3 (5%)       2 (3%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       4 (7%)       3 (5%)       1 (2%)                                
      Inflammation, Focal                             33 (55%)     33 (55%)     41 (68%)     45 (75%)                               
      Mixed Cell Focus                                 5 (8%)       8 (13%)      4 (7%)       7 (12%)                               
      Necrosis, Focal                                  2 (3%)       1 (2%)                    1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Dilatation                                         1 (2%)                                                          
      Bile Duct, Hyperplasia                          27 (45%)     25 (42%)     24 (40%)     33 (55%)                               
      Centrilobular, Atrophy                          14 (23%)     11 (18%)      4 (7%)       2 (3%)                                
      Centrilobular, Congestion                                                  1 (2%)                                             
      Centrilobular, Hemorrhage                        1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (11)         (9)          (10)         (6)                                    
      Accessory Spleen                                              1 (11%)                   1 (17%)                               
      Cyst                                                                       1 (10%)                                            
      Inflammation, Chronic                                         1 (11%)      1 (10%)      1 (17%)                               
      Fat, Necrosis                                    7 (64%)      4 (44%)      7 (70%)      4 (67%)                               
   Pancreas                                           (60)         (60)         (59)         (59)                                   
      Accessory Spleen                                 1 (2%)       1 (2%)                                                          
      Atrophy, Diffuse                                 2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Atrophy, Focal                                  21 (35%)     18 (30%)     21 (36%)     13 (22%)                               
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Acinar Cell, Depletion Secretory                                           1 (2%)                                             
      Duct, Dilatation                                              1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (59)         (59)                                   
      Edema                                                         1 (2%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Ulcer                                            1 (2%)                    2 (3%)                                             
      Mucosa, Hyperplasia                              2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (59)                                   
      Bacterium                                        1 (2%)                                                                       
      Erosion                                          2 (3%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Tongue                                                                       (1)          (1)                                    
      Hypertrophy, Squamous                                                                   1 (100%)                              
   Tooth                                              (1)                                                                           
      Gingiva, Hyperplasia                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)                                   
      Mesenteric Artery, Inflammation, Chronic         1 (2%)                                 2 (3%)                                
      Mesenteric Artery, Thrombosis                    1 (2%)                                                                       
   Heart                                              (60)         (60)         (60)         (60)                                   
      Bacterium                                        1 (2%)                                                                       
      Embolus                                          1 (2%)                                                                       
      Inflammation, Chronic, Focal                     2 (3%)                                 1 (2%)                                
      Artery, Inflammation, Chronic                                              2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                2 (3%)                    1 (2%)       3 (5%)                                
      Angiectasis                                      1 (2%)       2 (3%)                                                          
      Congestion                                       4 (7%)       1 (2%)                    2 (3%)                                
      Degeneration, Cystic                                                       2 (3%)                                             
      Depletion Cellular                               1 (2%)                                                                       
      Focal Cellular Change                           13 (22%)      9 (15%)     10 (17%)     13 (22%)                               
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Capsule, Extra Adrenal Tissue, Fibrosis                                                 1 (2%)                                
   Adrenal Medulla                                    (59)         (60)         (60)         (60)                                   
      Hyperplasia                                      2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
   Pituitary Gland                                    (60)         (60)         (59)         (59)                                   
      Angiectasis                                     19 (32%)     13 (22%)     12 (20%)     11 (19%)                               
      Cyst                                             4 (7%)       6 (10%)      2 (3%)       4 (7%)                                
      Granuloma                                        1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Cyst                                           1 (2%)                    1 (2%)                                
      Pars Distalis, Focal Cellular Change             6 (10%)      4 (7%)       2 (3%)       3 (5%)                                
      Pars Distalis, Hyperplasia, Focal               16 (27%)     11 (18%)     14 (24%)      9 (15%)                               
      Rathke's Cleft, Hyperplasia, Cystic                           1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      Degeneration, Cystic                             1 (2%)                                                                       
      Inflammation, Focal                                           1 (2%)                                                          
      Ultimobranchial Cyst                                          2 (3%)       3 (5%)                                             
      C-Cell, Hyperplasia                             10 (17%)      8 (14%)     11 (18%)     14 (23%)                               
      Follicle, Dilatation                                          1 (2%)                                                          
      Follicular Cell, Hyperplasia                                  2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (59)         (59)         (60)                                   
      Atrophy                                                       1 (2%)                                                          
      Cyst                                             1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Degeneration, Cystic                            42 (70%)     43 (73%)     47 (80%)     39 (65%)                               
      Hyperplasia                                     10 (17%)      6 (10%)      6 (10%)      7 (12%)                               
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Duct, Hyperplasia, Squamous                                   1 (2%)                                                          
   Ovary                                              (60)         (60)         (60)         (59)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Atrophy                                                                    1 (2%)                                             
      Cyst                                             5 (8%)      10 (17%)     10 (17%)      9 (15%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Bilateral, Cyst                                                            1 (2%)                                             
      Corpus Luteum, Hyperplasia, Lymphoid             2 (3%)       1 (2%)                                                          
      Corpus Luteum, Thecal Cell, Hyperplasia          2 (3%)       1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (59)                                   
      Hydrometra                                       1 (2%)       6 (10%)      5 (8%)       3 (5%)                                
      Endometrium, Cyst                                             1 (2%)       1 (2%)       1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 3 (5%)      10 (17%)      4 (7%)       6 (10%)                               
      Endometrium, Infarct                             2 (3%)                                                                       
   Vagina                                             (3)          (2)          (3)                                                 
      Cyst                                             2 (67%)      2 (100%)     1 (33%)                                            
      Cyst, Multiple                                                             1 (33%)                                            
      Inflammation, Chronic                                                      1 (33%)                                            
      Mucosa, Hyperplasia                              1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hypercellularity                                 2 (3%)       4 (7%)       2 (3%)       3 (5%)                                
      Hyperplasia, Focal, Histiocytic                  3 (5%)       4 (7%)       4 (7%)       4 (7%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (14)         (14)         (11)         (10)                                   
      Deep Cervical, Angiectasis                                                 1 (9%)                                             
      Inguinal, Depletion Lymphoid                                  1 (7%)                                                          
      Inguinal, Hyperplasia                                                                   2 (20%)                               
      Mediastinal, Angiectasis                                                   1 (9%)                                             
      Mediastinal, Congestion                          1 (7%)       3 (21%)      7 (64%)      1 (10%)                               
      Mediastinal, Depletion Lymphoid                               1 (7%)                                                          
      Mediastinal, Hyperplasia                                                                3 (30%)                               
      Mediastinal, Hyperplasia, Lymphoid                            1 (7%)                                                          
      Mediastinal, Hyperplasia, Macrophage                                       1 (9%)                                             
      Mediastinal, Pigmentation                                                  2 (18%)      2 (20%)                               
      Pancreatic, Congestion                                        2 (14%)                                                         
      Pancreatic, Depletion Lymphoid                                1 (7%)                                                          
      Pancreatic, Edema                                                                       1 (10%)                               
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (10%)                               
      Pancreatic, Inflammation, Chronic                                                       1 (10%)                               
      Pancreatic, Pigmentation                                                                1 (10%)                               
      Renal, Hyperplasia, Macrophage                                                          1 (10%)                               
      Renal, Pigmentation                                                                     1 (10%)                               
   Lymph Node, Mandibular                             (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       1 (2%)       2 (3%)       4 (7%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Lymphoid                                            1 (2%)                                                          
      Hyperplasia                                                   2 (3%)       2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         2 (3%)                                                          
      Pigmentation                                                                            2 (3%)                                
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (59)                                   
      Congestion                                                    1 (2%)                                                          
      Depletion Lymphoid                                            1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Cyst                                                                                    1 (2%)                                
      Fibrosis                                         1 (2%)       6 (10%)                   1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)      14 (23%)      9 (15%)      8 (14%)                               
      Necrosis, Focal                                  2 (3%)                    1 (2%)                                             
      Pigmentation                                    60 (100%)    60 (100%)    60 (100%)    59 (100%)                              
   Thymus                                             (59)         (58)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Dilatation                                      44 (73%)     40 (67%)     42 (70%)     37 (62%)                               
      Hyperplasia                                      9 (15%)     15 (25%)     13 (22%)     16 (27%)                               
   Skin                                               (60)         (60)         (60)         (60)                                   
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Hemorrhage, Focal                                                          1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fracture Healed                                                            1 (2%)                                             
      Hyperostosis                                    18 (30%)     11 (18%)      9 (15%)      9 (15%)                               
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      8 (13%)     16 (27%)     11 (18%)     14 (23%)                               
      Demyelination, Focal                                                       1 (2%)                                             
      Hemorrhage                                       4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
   Spinal Cord                                        (1)          (2)          (2)                                                 
      Hemorrhage, Focal                                                          1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Bacterium                                        1 (2%)                                                                       
      Congestion                                                    1 (2%)       2 (3%)                                             
      Fibrosis, Focal                                  1 (2%)                                 1 (2%)                                
      Hemorrhage, Focal                                                          2 (3%)                                             
      Hyperplasia, Focal, Macrophage                                             1 (2%)       2 (3%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       1 (2%)       1 (2%)                                             
      Metaplasia, Focal, Osseous                       1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (5%)       3 (5%)       4 (7%)       4 (7%)                                
      Mediastinum, Infiltration Cellular,                                                                                           
          Lymphocyte                                                1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (59)                                   
      Fungus                                                                                  1 (2%)                                
      Inflammation, Suppurative                        2 (3%)       4 (7%)       5 (8%)       2 (3%)                                
      Nasolacrimal Duct, Cyst                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (2)          (2)          (1)                                    
      Atrophy                                                                    1 (50%)                                            
      Cataract                                         3 (75%)      1 (50%)      2 (100%)     1 (100%)                              
      Fibrosis                                         1 (25%)                                                                      
      Hemorrhage                                       1 (25%)      1 (50%)      1 (50%)                                            
      Inflammation, Chronic                            1 (25%)      1 (50%)      1 (50%)                                            
      Necrosis, Focal                                               1 (50%)                                                         
      Retina, Degeneration                             3 (75%)      1 (50%)      2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Atrophy, Focal                                                             1 (2%)                                             
      Bacterium                                        1 (2%)                                                                       
      Congestion                                                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cyst                                                                       1 (2%)       1 (2%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Nephropathy                                     60 (100%)    59 (98%)     58 (97%)     58 (97%)                               
      Cortex, Renal Tubule, Autolysis                  1 (2%)                                                                       
      Glomerulus, Autolysis                            1 (2%)                                                                       
      Interstitium, Infarct                                                                   1 (2%)                                
      Papilla, Epithelium, Hyperplasia, Focal                                                 1 (2%)                                
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Hyperplasia, Oncocytic                          1 (2%)                    5 (8%)                                
      Renal Tubule, Pigmentation                      60 (100%)    60 (100%)    60 (100%)    60 (100%)                              
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                32           34           34           25                                     
    Natural Death                                      6            3            3            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           13           13           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (60)         (59)         (59)                                   
      Parasite Metazoan                                2 (3%)                    1 (2%)       2 (3%)                                
   Intestine Large, Rectum                            (59)         (60)         (59)         (60)                                   
      Parasite Metazoan                                3 (5%)       4 (7%)       5 (8%)       1 (2%)                                
   Intestine Large, Cecum                             (59)         (60)         (59)         (60)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Duodenum                          (58)         (58)         (59)         (60)                                   
      Mucosa, Hyperplasia                              1 (2%)                                                                       
   Intestine Small, Jejunum                           (59)         (59)         (59)         (60)                                   
      Necrosis                                                      1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (58)         (59)         (59)         (60)                                   
      Diverticulum                                                  1 (2%)                                                          
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (59)         (60)         (60)         (60)                                   
      Angiectasis                                      4 (7%)       6 (10%)      6 (10%)      1 (2%)                                
      Atrophy, Focal                                   1 (2%)                                                                       
      Autolysis                                                                  1 (2%)                                             
      Basophilic Focus                                18 (31%)     19 (32%)     30 (50%)     35 (58%)                               
      Clear Cell Focus                                 8 (14%)      8 (13%)      9 (15%)     12 (20%)                               
      Congestion, Focal                                3 (5%)       1 (2%)                                                          
      Degeneration, Cystic                             7 (12%)     11 (18%)     11 (18%)     12 (20%)                               
      Developmental Malformation                                                              1 (2%)                                
      Eosinophilic Focus                               5 (8%)       5 (8%)       7 (12%)      5 (8%)                                
      Fatty Change                                    25 (42%)     21 (35%)     21 (35%)     16 (27%)                               
      Fibrosis, Focal                                                            1 (2%)                                             
      Focal Cellular Change                                         1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)       2 (3%)                                
      Hemorrhage, Focal                                                                       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatodiaphragmatic Nodule                       7 (12%)      2 (3%)      12 (20%)      9 (15%)                               
      Hepatodiaphragmatic Nodule, Multiple             2 (3%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Multifocal                         13 (22%)     12 (20%)     13 (22%)      4 (7%)                                
      Infiltration Cellular, Mixed Cell                7 (12%)      5 (8%)       4 (7%)       3 (5%)                                
      Inflammation, Focal                             18 (31%)     16 (27%)     22 (37%)     32 (53%)                               
      Mixed Cell Focus                                 2 (3%)       3 (5%)       1 (2%)       2 (3%)                                
      Necrosis, Focal                                               6 (10%)      3 (5%)       1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                                                 2 (3%)                                             
      Bile Duct, Hyperplasia                          58 (98%)     58 (97%)     59 (98%)     58 (97%)                               
      Centrilobular, Atrophy                          22 (37%)     27 (45%)     23 (38%)      5 (8%)                                
      Centrilobular, Congestion                        1 (2%)                                                                       
      Centrilobular, Necrosis                          2 (3%)                    1 (2%)       1 (2%)                                
   Mesentery                                          (18)         (14)         (15)         (20)                                   
      Accessory Spleen                                 1 (6%)       2 (14%)      1 (7%)       1 (5%)                                
      Angiectasis                                                   1 (7%)                                                          
      Fibrosis                                         1 (6%)                    1 (7%)       1 (5%)                                
      Hemorrhage                                       1 (6%)                                                                       
      Inflammation, Chronic                                                      1 (7%)       1 (5%)                                
      Fat, Necrosis                                   12 (67%)      5 (36%)      4 (27%)     16 (80%)                               
   Pancreas                                           (59)         (60)         (59)         (60)                                   
      Accessory Spleen                                 1 (2%)                                 1 (2%)                                
      Atrophy, Diffuse                                              1 (2%)                                                          
      Atrophy, Focal                                  30 (51%)     32 (53%)     29 (49%)     27 (45%)                               
      Edema                                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Acinar Cell, Focal Cellular Change                            1 (2%)                                                          
      Acinar Cell, Hyperplasia                                      1 (2%)       2 (3%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)       1 (2%)                                
      Duct, Dilatation                                                           2 (3%)                                             
   Salivary Glands                                    (59)         (59)         (60)         (60)                                   
      Atrophy, Focal                                                                          1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            1 (2%)       1 (2%)       1 (2%)                                             
      Erosion                                          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            2 (3%)       2 (3%)       3 (5%)                                             
      Mineralization, Focal                            1 (2%)                                                                       
      Ulcer                                            1 (2%)       2 (3%)       4 (7%)                                             
      Mucosa, Hyperplasia                              4 (7%)       3 (5%)       5 (8%)                                             
   Stomach, Glandular                                 (60)         (59)         (59)         (60)                                   
      Erosion                                          4 (7%)       2 (3%)       1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                                               1 (2%)                                             
      Pigmentation, Focal                              2 (3%)       1 (2%)       1 (2%)                                             
      Mucosa, Hyperplasia                                           1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tongue                                                                                    (2)                                    
      Hyperplasia, Squamous                                                                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (59)         (60)         (60)         (60)                                   
      Mesenteric Artery, Inflammation, Chronic         1 (2%)       1 (2%)                    2 (3%)                                
   Heart                                              (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)                    1 (2%)                                
      Thrombosis                                                                 2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                2 (3%)       1 (2%)       2 (3%)       3 (5%)                                
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Atrophy                                                                    1 (2%)                                             
      Congestion                                       2 (3%)                                                                       
      Focal Cellular Change                            4 (7%)       7 (12%)     11 (18%)      9 (15%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hyperplasia, Focal                                                                      1 (2%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                     11 (18%)      8 (13%)     15 (25%)      9 (15%)                               
   Pituitary Gland                                    (59)         (60)         (59)         (59)                                   
      Angiectasis                                      1 (2%)       3 (5%)       3 (5%)       4 (7%)                                
      Cyst                                             3 (5%)       4 (7%)       3 (5%)       4 (7%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Pars Distalis, Focal Cellular Change            11 (19%)      6 (10%)      6 (10%)     12 (20%)                               
      Pars Distalis, Hyperplasia, Focal                3 (5%)       7 (12%)      4 (7%)       1 (2%)                                
      Pars Nervosa, Focal Cellular Change                                        1 (2%)                                             
   Thyroid Gland                                      (59)         (59)         (59)         (60)                                   
      Degeneration, Cystic                             1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Ultimobranchial Cyst                                                       2 (3%)       2 (3%)                                
      C-Cell, Hyperplasia                              6 (10%)     13 (22%)      5 (8%)       9 (15%)                               
      Follicle, Dilatation                             1 (2%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia                     2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)                       (2)                                    
      Anterior, Fibrosis                               1 (50%)                                                                      
      Anterior, Inflammation, Chronic                  1 (50%)                                                                      
      Oral, Inflammation, Chronic                                                             1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (60)                                   
      Inflammation, Chronic                                         1 (2%)                    2 (3%)                                
      Epithelium, Degeneration                                      1 (2%)                                                          
   Preputial Gland                                    (60)         (60)         (59)         (60)                                   
      Degeneration, Cystic                            57 (95%)     57 (95%)     58 (98%)     58 (97%)                               
      Hyperplasia                                      4 (7%)                    1 (2%)       3 (5%)                                
      Inflammation, Chronic                            2 (3%)                    3 (5%)                                             
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Suppurative                       45 (75%)     37 (62%)     43 (72%)     44 (73%)                               
      Epithelium, Hyperplasia, Focal                   1 (2%)       7 (12%)      2 (3%)                                             
   Seminal Vesicle                                    (60)         (60)         (59)         (60)                                   
      Dilatation                                       2 (3%)       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
   Testes                                             (60)         (60)         (59)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Mineralization, Focal                                                                   1 (2%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Bilateral, Interstitial Cell, Hyperplasia        2 (3%)                    3 (5%)      10 (17%)                               
      Germinal Epithelium, Degeneration                7 (12%)     12 (20%)     13 (22%)     14 (23%)                               
      Interstitial Cell, Hyperplasia                  15 (25%)     15 (25%)      9 (15%)     17 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                              2 (3%)                                
      Hypercellularity                                 5 (8%)       3 (5%)       6 (10%)      5 (8%)                                
      Hyperplasia, Focal, Histiocytic                  1 (2%)       1 (2%)                    3 (5%)                                
      Metaplasia, Osseous                                           1 (2%)                                                          
      Myelofibrosis                                                 2 (3%)       1 (2%)       1 (2%)                                
   Lymph Node                                         (26)         (26)         (32)         (15)                                   
      Inguinal, Hyperplasia                                                      1 (3%)       4 (27%)                               
      Lumbar, Hyperplasia                                                                     1 (7%)                                
      Mediastinal, Angiectasis                                      3 (12%)                   1 (7%)                                
      Mediastinal, Congestion                          3 (12%)      2 (8%)       6 (19%)      5 (33%)                               
      Mediastinal, Hyperplasia                         1 (4%)       1 (4%)       1 (3%)       4 (27%)                               
      Mediastinal, Pigmentation                                                  3 (9%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Angiectasis                          1 (4%)                    1 (3%)       1 (7%)                                
      Pancreatic, Edema                                2 (8%)                    1 (3%)       1 (7%)                                
      Pancreatic, Hyperplasia                          2 (8%)                                 1 (7%)                                
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (7%)                                
      Pancreatic, Hyperplasia, Macrophage                                                     1 (7%)                                
   Lymph Node, Mandibular                             (59)         (59)         (59)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Congestion                                       1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Ectasia                                                       1 (2%)                                                          
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      7 (12%)      8 (14%)      7 (12%)     16 (27%)                               
   Lymph Node, Mesenteric                             (59)         (60)         (59)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Edema                                            1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Hyperplasia                                      5 (8%)       3 (5%)       1 (2%)       7 (12%)                               
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    3 (5%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Degeneration, Fatty                                                        1 (2%)                                             
      Fibrosis                                        12 (20%)     14 (23%)     12 (20%)      7 (12%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)       7 (12%)      9 (15%)                               
      Necrosis, Focal                                  1 (2%)       4 (7%)       1 (2%)                                             
      Pigmentation                                    60 (100%)    60 (100%)    60 (100%)    60 (100%)                              
      Red Pulp, Hyperplasia, Focal, Histiocytic                     1 (2%)                                                          
   Thymus                                             (57)         (59)         (58)         (56)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    2 (4%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (57)         (58)         (54)                                   
      Dilatation                                      19 (32%)     11 (19%)     18 (31%)      9 (17%)                               
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia                                      6 (10%)      3 (5%)       2 (3%)       2 (4%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
   Skin                                               (60)         (60)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Exudate                                                                                 1 (2%)                                
      Hemorrhage, Focal                                1 (2%)       2 (3%)       1 (2%)                                             
      Hyperkeratosis, Focal                                         2 (3%)       4 (7%)       2 (3%)                                
      Hyperplasia, Focal                                                         1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic, Focal                     1 (2%)                    3 (5%)       2 (3%)                                
      Ulcer                                            1 (2%)                    1 (2%)       1 (2%)                                
      Epidermis, Hyperplasia, Focal                                 2 (3%)       4 (7%)       2 (3%)                                
      Subcutaneous Tissue, Angiectasis                 1 (2%)                                                                       
      Subcutaneous Tissue, Congestion                                                         1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fracture                                         1 (2%)                                 2 (3%)                                
      Hyperostosis                                                               1 (2%)       1 (2%)                                
      Trabecula, Proliferation                                                   1 (2%)                                             
   Skeletal Muscle                                    (1)                       (1)          (1)                                    
      Inflammation, Chronic                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      8 (13%)      5 (8%)       5 (8%)       2 (3%)                                
      Hemorrhage                                       2 (3%)       4 (7%)                                                          
      Meninges, Fibrosis, Focal                                     1 (2%)                                                          
   Spinal Cord                                        (2)          (4)          (2)                                                 
      Demyelination                                                 1 (25%)                                                         
      Hemorrhage, Focal                                1 (50%)      1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       2 (3%)                    2 (3%)       2 (3%)                                
      Edema                                            1 (2%)                                                                       
      Fibrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Hemorrhage, Focal                                1 (2%)       3 (5%)       3 (5%)                                             
      Hyperplasia, Diffuse, Macrophage                              1 (2%)                                                          
      Hyperplasia, Focal, Macrophage                   2 (3%)       2 (3%)       2 (3%)                                             
      Infiltration Cellular, Mixed Cell                                          1 (2%)       2 (3%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 6 (10%)      6 (10%)      7 (12%)      4 (7%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Fungus                                           6 (10%)      9 (15%)      8 (13%)      8 (13%)                               
      Inflammation, Suppurative                        8 (13%)     11 (18%)     12 (20%)      9 (15%)                               
      Respiratory Epithelium, Hyperplasia, Focal                                              1 (2%)                                
      Respiratory Epithelium, Ulcer                                 1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05155-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 16:48:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (2)          (1)                                    
      Atrophy                                                                    1 (50%)      1 (100%)                              
      Cataract                                                      1 (100%)     2 (100%)     1 (100%)                              
      Retina, Degeneration                                          1 (100%)     2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Autolysis                                                                  1 (2%)                                             
      Congestion                                                    1 (2%)                                                          
      Cyst                                                          1 (2%)                    1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Nephropathy                                     60 (100%)    60 (100%)    60 (100%)    60 (100%)                              
      Thrombosis                                                                 1 (2%)                                             
      Pelvis, Dilatation                               1 (2%)       1 (2%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)       2 (3%)                                                          
      Renal Tubule, Hyperplasia                                     3 (5%)       2 (3%)       1 (2%)                                
      Renal Tubule, Hyperplasia, Oncocytic             1 (2%)                    1 (2%)       5 (8%)                                
      Renal Tubule, Pigmentation                      60 (100%)    60 (100%)    60 (100%)    60 (100%)                              
      Renal Tubule, Vacuolization Cytoplasmic                                                 1 (2%)                                
   Urinary Bladder                                    (60)         (60)         (59)         (60)                                   
      Dilatation                                       1 (2%)                                                                       
      Hemorrhage                                       2 (3%)       1 (2%)                                                          
      Inflammation, Chronic                                                                   1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.