Share This:
https://ntp.niehs.nih.gov/go/2358

TDMS Study 05155-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        P-NITROBENZOIC ACID


NTP Experiment-Test: 05155-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: DOSED FEED                                                                                                 Time: 17:03:39




       Facility:  Southern Research Institute

       Chemical CAS #:  62-23-7

       Lock Date:  02/15/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           23           27           26                                     
    Natural Death                                      2            4            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           23           21           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Intestine Large, Colon                             (60)         (58)         (60)         (60)                                   
      Leiomyosarcoma, Metastatic, Uterus                            1 (2%)                                                          
   Intestine Large, Cecum                             (60)         (57)         (60)         (59)                                   
   Intestine Small, Duodenum                          (60)         (60)         (60)         (59)                                   
   Intestine Small, Ileum                             (60)         (57)         (60)         (58)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Adenoma                           2 (3%)                                                                       
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Mesentery                                          (11)         (9)          (10)         (6)                                    
      Sarcoma                                                                    1 (10%)                                            
      Schwannoma Malignant, Metastatic, Uterus                                   1 (10%)                                            
   Pancreas                                           (60)         (60)         (59)         (59)                                   
      Acinar Cell, Adenoma                                                       1 (2%)                                             
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (59)         (59)                                   
   Stomach, Glandular                                 (60)         (60)         (59)         (59)                                   
   Tongue                                                                       (1)          (1)                                    
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Adrenal Medulla                                    (59)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Benign                          2 (3%)       1 (2%)       3 (5%)                                             
   Islets, Pancreatic                                 (60)         (60)         (59)         (59)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (60)         (60)         (59)         (59)                                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pars Distalis, Adenoma                          20 (33%)     29 (48%)     26 (44%)     26 (44%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Nervosa, Ganglioneuroma                                                            1 (2%)                                
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      C-Cell, Adenoma                                  9 (15%)      4 (7%)       5 (8%)       2 (3%)                                
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      C-Cell, Carcinoma                                1 (2%)                    2 (3%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (59)         (59)         (60)                                   
      Adenoma                                          4 (7%)      12 (20%)      9 (15%)     11 (18%)                               
      Carcinoma                                        1 (2%)       2 (3%)       4 (7%)       3 (5%)                                
      Bilateral, Adenoma                                                         1 (2%)       1 (2%)                                
      Bilateral, Carcinoma                                                       1 (2%)       1 (2%)                                
   Ovary                                              (60)         (60)         (60)         (59)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Neoplasm NOS                                                  1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyosarcoma                                                1 (2%)                                                          
      Endometrium, Polyp Stromal                       5 (8%)      13 (22%)     14 (23%)      6 (10%)                               
      Endometrium, Polyp Stromal, Multiple                          1 (2%)       1 (2%)                                             
      Endometrium, Sarcoma Stromal                                  1 (2%)       2 (3%)                                             
      Endometrium, Schwannoma Malignant                1 (2%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (14)         (14)         (11)         (10)                                   
      Renal, Sarcoma, Metastatic, Mesentery                                      1 (9%)                                             
   Lymph Node, Mandibular                             (60)         (60)         (60)         (60)                                   
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (59)                                   
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Thymus                                             (59)         (58)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (3%)       2 (3%)       3 (5%)       2 (3%)                                
      Fibroadenoma                                    17 (28%)     16 (27%)     19 (32%)     19 (32%)                               
      Fibroadenoma, Multiple                           5 (8%)       7 (12%)      7 (12%)      5 (8%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Basosquamous Tumor Malignant                     1 (2%)                                                                       
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     2 (3%)       1 (2%)                    3 (5%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)       1 (2%)                                             
   Skeletal Muscle                                                              (1)          (1)                                    
      Rhabdomyosarcoma                                                           1 (100%)                                           
      Sarcoma                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma NOS                                               1 (2%)                                                          
      Glioma Malignant                                 1 (2%)                                                                       
   Peripheral Nerve                                   (2)          (4)          (2)                                                 
      Schwannoma Malignant                                          1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Osteosarcoma, Multiple, Metastatic, Bone                      1 (2%)                                                          
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Nose                                               (60)         (60)         (60)         (59)                                   
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Pelvis, Transitional Epithelium, Mesenchymal                                                                                  
          Nos                                                                    1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            17 (28%)     12 (20%)      3 (5%)                                             
      Mesothelioma Malignant                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          53          55          49                                       
     Total Primary Neoplasms                           97         109         113          87                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          46          48          45                                       
     Total Benign Neoplasms                            70          85          89          76                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          20          22          10                                       
     Total Malignant Neoplasms                         27          22          23          11                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           2           1                                       
     Total Metastatic Neoplasm                                      5           4           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              2           1                                                   
     Total Uncertain Neoplasms                                      2           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                32           34           34           25                                     
    Natural Death                                      6            3            3            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           13           13           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (60)         (59)         (59)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Rectum                            (59)         (60)         (59)         (60)                                   
   Intestine Large, Cecum                             (59)         (60)         (59)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Intestine Small, Duodenum                          (58)         (58)         (59)         (60)                                   
   Intestine Small, Jejunum                           (59)         (59)         (59)         (60)                                   
      Carcinoma                                        2 (3%)                                                                       
   Intestine Small, Ileum                             (58)         (59)         (59)         (60)                                   
   Liver                                              (59)         (60)         (60)         (60)                                   
      Hepatocellular Carcinoma                         3 (5%)                                 2 (3%)                                
      Hepatocellular Adenoma                           2 (3%)       2 (3%)       1 (2%)       2 (3%)                                
      Hepatocellular Adenoma, Multiple                              2 (3%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Mesentery                                          (18)         (14)         (15)         (20)                                   
      Carcinoma, Metastatic, Kidney                                              1 (7%)                                             
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (7%)                                                          
   Pancreas                                           (59)         (60)         (59)         (60)                                   
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (2%)                                                          
      Acinar Cell, Adenoma                             2 (3%)       3 (5%)                                                          
   Pharynx                                            (1)                       (3)                                                 
      Palate, Squamous Cell Papilloma                  1 (100%)                  2 (67%)                                            
   Salivary Glands                                    (59)         (59)         (60)         (60)                                   
      Schwannoma Malignant                             1 (2%)                                 1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
   Stomach, Glandular                                 (60)         (59)         (59)         (60)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Tongue                                                                                    (2)                                    
      Squamous Cell Papilloma                                                                 1 (50%)                               
                                                             Page   7                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant                       2 (3%)                    1 (2%)       2 (3%)                                
      Pheochromocytoma Benign                          8 (13%)      7 (12%)      6 (10%)     11 (18%)                               
      Bilateral, Pheochromocytoma Benign               2 (3%)       4 (7%)       2 (3%)       1 (2%)                                
   Islets, Pancreatic                                 (59)         (60)         (59)         (60)                                   
      Adenoma                                          2 (3%)       1 (2%)       2 (3%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (57)         (59)         (57)         (59)                                   
   Pituitary Gland                                    (59)         (60)         (59)         (59)                                   
      Pars Distalis, Adenoma                          20 (34%)     14 (23%)     20 (34%)     13 (22%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (59)         (59)         (59)         (60)                                   
      C-Cell, Adenoma                                  4 (7%)       2 (3%)       2 (3%)       3 (5%)                                
      C-Cell, Carcinoma                                             1 (2%)       3 (5%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)                       (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (60)                                   
   Preputial Gland                                    (60)         (60)         (59)         (60)                                   
      Adenoma                                          4 (7%)       2 (3%)       5 (8%)       4 (7%)                                
      Carcinoma                                        1 (2%)       1 (2%)       3 (5%)       5 (8%)                                
      Bilateral, Adenoma                                            1 (2%)                                                          
      Bilateral, Carcinoma                                                       1 (2%)       1 (2%)                                
      Duct, Squamous Cell Papilloma                                              1 (2%)                                             
   Prostate                                           (60)         (60)         (60)         (60)                                   
   Seminal Vesicle                                    (60)         (60)         (59)         (60)                                   
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (2%)                                                          
   Testes                                             (60)         (60)         (59)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           38 (63%)     43 (72%)     42 (71%)     21 (35%)                               
                                                             Page   8                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Interstitial Cell, Adenoma                      15 (25%)     10 (17%)     11 (19%)     16 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (26)         (26)         (32)         (15)                                   
      Mediastinal, Carcinoma, Metastatic, Kidney                                 1 (3%)                                             
      Pancreatic, Carcinoma, Metastatic, Kidney                                  1 (3%)                                             
      Renal, Carcinoma, Metastatic, Kidney                                       1 (3%)                                             
   Lymph Node, Mandibular                             (59)         (59)         (59)         (60)                                   
   Lymph Node, Mesenteric                             (59)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Histiocytic Sarcoma                                                                     2 (3%)                                
   Thymus                                             (57)         (59)         (58)         (56)                                   
      Epithelial Cell, Thymoma Benign                  1 (2%)       1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (57)         (58)         (54)                                   
      Fibroadenoma                                     3 (5%)       1 (2%)       4 (7%)       2 (4%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                                                         1 (2%)       1 (2%)                                
      Keratoacanthoma                                  3 (5%)       3 (5%)       3 (5%)       2 (3%)                                
      Squamous Cell Papilloma                                                    2 (3%)                                             
      Trichoepithelioma                                                                       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     4 (7%)       6 (10%)      4 (7%)       7 (12%)                               
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 4 (7%)                                
      Subcutaneous Tissue, Lipoma                                   1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                  2 (3%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (1)                       (1)          (1)                                    
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Glioma Malignant                                 1 (2%)                                                                       
   Peripheral Nerve                                   (2)          (5)          (1)                                                 
      Schwannoma Malignant                             1 (50%)      1 (20%)                                                         
   Spinal Cord                                        (2)          (4)          (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Multiple, Metastatic, Kidney                                    1 (2%)                                             
      Osteosarcoma, Multiple, Metastatic, Bone                      1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Nasolacrimal Duct, Squamous Cell Carcinoma       1 (2%)                                                                       
   Trachea                                            (59)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (2)                                                 
      Pinna, Fibrosarcoma                                           1 (100%)                                                        
   Zymbal's Gland                                     (2)                                                                           
      Adenoma                                          1 (50%)                                                                      
      Carcinoma                                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Pelvis, Transitional Epithelium, Papilloma       1 (2%)                                                                       
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (59)         (60)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                                     2 (3%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            29 (48%)     36 (60%)     26 (43%)      2 (3%)                                
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                                        2 (3%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page  11                                                               
NTP Experiment-Test: 05155-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        P-NITROBENZOIC ACID                                    Date: 05/08/95  
Route: DOSED FEED                                                                                                 Time: 17:03:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.125%       0.25%        0.5%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            57          59          59          50                                       
     Total Primary Neoplasms                          158         149         155         113                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 56          57          58          45                                       
     Total Benign Neoplasms                           111         104         117          89                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          39          34          20                                       
     Total Malignant Neoplasms                         47          45          38          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           2                                                   
     Total Metastatic Neoplasm                          1           5           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------