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TDMS Study 05155-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                P-NITROBENZOIC ACID                                 DATE: 05/08/95       
EXPERIMENT: 05155 TEST: 03                                                                                     TIME: 17:13:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85217          ROUTE: DOSED FEED                                                                  NTP C#: 61778B       
PATHOLOGIST: DR D. FARNELL                   HAILEY, JAMES R.                                                  CAS: 62-23-7         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                P-NITROBENZOIC ACID                                 DATE: 05/08/95       
EXPERIMENT: 05155 TEST: 03                                                                                     TIME: 17:13:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85217          ROUTE: DOSED FEED                                                                  NTP C#: 61778B       
PATHOLOGIST: DR D. FARNELL                   HAILEY, JAMES R.                                                  CAS: 62-23-7         


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                P-NITROBENZOIC ACID                                 DATE: 05/08/95       
EXPERIMENT: 05155 TEST: 03                                                                                     TIME: 17:13:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85217          ROUTE: DOSED FEED                                                                  NTP C#: 61778B       
PATHOLOGIST: DR D. FARNELL                   HAILEY, JAMES R.                                                  CAS: 62-23-7         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF P-NITROBENZOIC ACID
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Clitoral/Preputial Gland      Carcinoma
                                            Carcinoma or Adenoma
              Islets, Pancreatic            Carcinoma or Adenoma
              Lung                          Alveolar/Bronchiolar Adenoma
              Pancreas                      Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Skin                          Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma
                                            Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,
                                             malignant or NOS), or Trichoepithelioma
                                            Fibrosarcoma
              Testes                        Adenoma
              All Organs                    Histiocytic Sarcoma
                                            Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Malignant Lymphoma And Histiocytic Sarcoma
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Clitoral/Preputial Gland      Adenoma
                                            Carcinoma or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              Uterus                        Polyp Stromal
                                            Sarcoma Stromal or Polyp Stromal
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   1
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)  11/60 (18%)   8/60 (13%)  12/60 (20%) |  2/59 (3%)    1/60 (2%)    3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |  44.4%        57.2%        34.5%        42.6%      |   5.4%         4.3%        11.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/12 (25%)   6/13 (46%)   3/13 (23%)   6/21 (29%) |  0/26 (0%)    1/23 (4%)    2/21 (10%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   631          591          456 (I)      608       |   647          730 (T)      518          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.264N     P=0.580N     P=0.316N     P=0.339N   |  P=0.298N     P=0.557N     P=0.402      P=0.289N   |
|INCIDENTAL TUMOR       |  P=0.538N     P=0.580      P=0.315N     P=0.508    |  P=0.236N     P=0.528N     P=0.578      P=0.278N   |
|LOGISTIC REGRESSION    |  P=0.486N     P=0.583N     P=0.298N     P=0.500    |  P=0.259N     P=0.523N     P=0.467      P=0.248N   |
|COCHRAN-ARMITAGE       |  P=0.397                                           |  P=0.238N                                          |
|FISHER EXACT           |               P=0.500      P=0.399N     P=0.407    |               P=0.494N     P=0.508      P=0.244N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |  0/59 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  16.7%         0.0%         3.6%         7.7%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/26 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          672          703       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.603N     P=0.217N     P=0.463N     P=0.499N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.521      P=0.217N     P=0.460N     P=0.622N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.572      P=0.217N     P=0.448N     P=0.555N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.470                                           |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.500N     P=0.691N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   2
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/60 (18%)  11/60 (18%)   9/60 (15%)  13/60 (22%) |  2/59 (3%)    1/60 (2%)    3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |  50.6%        57.2%        36.8%        44.8%      |   5.4%         4.3%        11.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/12 (33%)   6/13 (46%)   3/13 (23%)   6/21 (29%) |  0/26 (0%)    1/23 (4%)    2/21 (10%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   631          591          456 (I)      608       |   647          730 (T)      518          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.271N     P=0.483N     P=0.313N     P=0.303N   |  P=0.298N     P=0.557N     P=0.402      P=0.289N   |
|INCIDENTAL TUMOR       |  P=0.531      P=0.518N     P=0.309N     P=0.529    |  P=0.236N     P=0.528N     P=0.578      P=0.278N   |
|LOGISTIC REGRESSION    |  P=0.503N     P=0.472N     P=0.291N     P=0.531    |  P=0.259N     P=0.523N     P=0.467      P=0.248N   |
|COCHRAN-ARMITAGE       |  P=0.368                                           |  P=0.238N                                          |
|FISHER EXACT           |               P=0.593N     P=0.404N     P=0.410    |               P=0.494N     P=0.508      P=0.244N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |  1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         6.3%         2.5%         2.9%      |   2.0%         1.7%         4.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          591          570          618       |   556          441          709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.553      P=0.266      P=0.538      P=0.545    |  P=0.339N     P=0.744      P=0.701      P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.371      P=0.231      P=0.500      P=0.379    |  P=0.204N     P=0.605N     P=0.740      P=0.388N   |
|LOGISTIC REGRESSION    |  P=0.502      P=0.246      P=0.483      P=0.506    |  P=0.291N     P=0.683N     P=0.763N     P=0.467N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.312N                                          |
|FISHER EXACT           |               P=0.248      P=0.500      P=0.500    |               P=0.752N     P=0.752N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   3
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    3/60 (5%)    5/59 (8%)    4/60 (7%)  |  4/60 (7%)   12/59 (20%)  10/59 (17%)  12/60 (20%) |
|ADJUSTED (b)           |  22.5%        13.6%        17.9%        12.0%      |  11.9%        42.5%        33.7%        42.1%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    1/13 (8%)    1/21 (5%)  |  2/27 (7%)    7/22 (32%)   4/20 (20%)   7/21 (33%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      588          456 (I)      456 (I)   |   653          665          496          483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.441N     P=0.444N     P=0.549      P=0.443N   |  P=0.034 *    P=0.013 *    P=0.030 *    P=0.013 *  |
|INCIDENTAL TUMOR       |  P=0.515      P=0.474N     P=0.539      P=0.590N   |  P=0.038 *    P=0.013 *    P=0.049 *    P=0.022 *  |
|LOGISTIC REGRESSION    |  P=0.537      P=0.457N     P=0.525      P=0.604N   |  P=0.039 *    P=0.012 *    P=0.038 *    P=0.017 *  |
|COCHRAN-ARMITAGE       |  P=0.499                                           |  P=0.069                                           |
|FISHER EXACT           |               P=0.500N     P=0.489      P=0.641N   |               P=0.026 *    P=0.072      P=0.029 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    4/59 (7%)    6/60 (10%) |  1/60 (2%)    2/59 (3%)    5/59 (8%)    4/60 (7%)  |
|ADJUSTED (b)           |   2.7%         2.9%        15.9%        15.0%      |   3.7%         6.0%        19.3%        11.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  1/27 (4%)    0/22 (0%)    3/20 (15%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   548          602          651          518       |   730 (T)      694          499          528       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.031 *    P=0.744N     P=0.234      P=0.094    |  P=0.085      P=0.460      P=0.056      P=0.139    |
|INCIDENTAL TUMOR       |  P=0.004 **   P=0.720      P=0.216      P=0.026 *  |  P=0.131      P=0.463      P=0.099      P=0.267    |
|LOGISTIC REGRESSION    |  P=0.002 **   P=0.756      P=0.204      P=0.009 ** |  P=0.104      P=0.453      P=0.071      P=0.173    |
|COCHRAN-ARMITAGE       |  P=0.014 *                                         |  P=0.117                                           |
|FISHER EXACT           |               P=0.752N     P=0.177      P=0.057    |               P=0.494      P=0.100      P=0.182    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   4
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    4/60 (7%)    9/59 (15%)  10/60 (17%) |  4/60 (7%)   14/59 (24%)  15/59 (25%)  15/60 (25%) |
|ADJUSTED (b)           |  24.6%        16.1%        30.9%        25.1%      |  11.9%        45.9%        48.9%        47.7%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    1/10 (10%)   1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    1/13 (8%)    1/21 (5%)  |  2/27 (7%)    7/22 (32%)   7/20 (35%)   7/21 (33%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      588          456 (I)      456 (I)   |   653          665          496          483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.164      P=0.441N     P=0.270      P=0.292    |  P=0.008 **   P=0.005 **   P=0.001 **   P=0.002 ** |
|INCIDENTAL TUMOR       |  P=0.031 *    P=0.504N     P=0.246      P=0.106    |  P=0.009 **   P=0.004 **   P=0.003 **   P=0.005 ** |
|LOGISTIC REGRESSION    |  P=0.029 *    P=0.465N     P=0.227      P=0.075    |  P=0.009 **   P=0.003 **   P=0.002 **   P=0.003 ** |
|COCHRAN-ARMITAGE       |  P=0.051                                           |  P=0.020 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.188      P=0.135    |               P=0.009 **   P=0.005 **   P=0.005 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  13.2%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   689          ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.079N     P=0.215N     P=0.220N     P=0.134N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.094N     P=0.218N     P=0.211N     P=0.193N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.089N     P=0.206N     P=0.204N     P=0.169N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.115N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   5
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  13.2%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   689          ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.079N     P=0.215N     P=0.220N     P=0.134N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.094N     P=0.218N     P=0.211N     P=0.193N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.089N     P=0.206N     P=0.204N     P=0.169N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.115N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    1/60 (2%)    2/59 (3%)    0/60 (0%)  |  1/60 (2%)    0/60 (0%)    0/59 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |  14.4%         3.0%        13.1%         0.0%      |   3.7%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    0/13 (0%)    1/13 (8%)    0/21 (0%)  |  1/27 (4%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          624          709          ---       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.122N     P=0.458N     P=0.668N     P=0.140N   |  P=0.338N     P=0.532N     P=0.550N     P=0.550N   |
|INCIDENTAL TUMOR       |  P=0.179N     P=0.499N     P=0.647N     P=0.193N   |  P=0.338N     P=0.532N     P=0.550N     P=0.550N   |
|LOGISTIC REGRESSION    |  P=0.144N     P=0.459N     P=0.647N     P=0.148N   |  P=0.338N     P=0.532N     P=0.550N     P=0.550N   |
|COCHRAN-ARMITAGE       |  P=0.198N                                          |  P=0.308N                                          |
|FISHER EXACT           |               P=0.494N     P=0.691N     P=0.244N   |               P=0.500N     P=0.504N     P=0.504N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   6
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/59 (5%)    1/60 (2%)    2/59 (3%)    0/60 (0%)  |  1/60 (2%)    0/60 (0%)    0/59 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |  22.2%         3.0%        13.1%         0.0%      |   3.7%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    1/13 (8%)    0/21 (0%)  |  1/27 (4%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          624          709          ---       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.052N     P=0.268N     P=0.467N     P=0.048N*  |  P=0.338N     P=0.532N     P=0.550N     P=0.550N   |
|INCIDENTAL TUMOR       |  P=0.078N     P=0.299N     P=0.444N     P=0.069N   |  P=0.338N     P=0.532N     P=0.550N     P=0.550N   |
|LOGISTIC REGRESSION    |  P=0.064N     P=0.259N     P=0.434N     P=0.052N   |  P=0.338N     P=0.532N     P=0.550N     P=0.550N   |
|COCHRAN-ARMITAGE       |  P=0.103N                                          |  P=0.308N                                          |
|FISHER EXACT           |               P=0.303N     P=0.500N     P=0.119N   |               P=0.500N     P=0.504N     P=0.504N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         9.8%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    1/13 (8%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          541          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.657        (e)        P=0.259        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.638        (e)        P=0.224        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.607        (e)        P=0.251        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.595                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   7
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    4/60 (7%)    1/60 (2%)    2/60 (3%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.7%        23.0%         7.7%         7.9%      |   7.4%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    2/13 (15%)   1/13 (8%)    1/21 (5%)  |  2/27 (7%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   645          538          729 (T)      694       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.242N     P=0.386      P=0.465N     P=0.513N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|INCIDENTAL TUMOR       |  P=0.312N     P=0.384      P=0.460N     P=0.622N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|LOGISTIC REGRESSION    |  P=0.328N     P=0.388      P=0.448N     P=0.598N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|COCHRAN-ARMITAGE       |  P=0.426N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.348      P=0.494N     P=0.684N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/59 (5%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.8%         0.0%         0.0%         9.5%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    2/21 (10%) |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   617          ---          ---          729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.396N     P=0.104N     P=0.104N     P=0.324N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.501N     P=0.118N     P=0.101N     P=0.480N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.466N     P=0.107N     P=0.103N     P=0.408N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.526N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.119N     P=0.119N     P=0.492N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   8
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/59 (7%)    4/60 (7%)    1/60 (2%)    4/60 (7%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  19.2%        23.0%         7.7%        17.1%      |   7.4%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    2/13 (15%)   1/13 (8%)    3/21 (14%) |  2/27 (7%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   617          538          729 (T)      694       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.277N     P=0.581N     P=0.154N     P=0.381N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|INCIDENTAL TUMOR       |  P=0.388N     P=0.606N     P=0.152N     P=0.563N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|LOGISTIC REGRESSION    |  P=0.391N     P=0.587N     P=0.139N     P=0.504N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|COCHRAN-ARMITAGE       |  P=0.512N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.632N     P=0.177N     P=0.632N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/59 (7%)    4/60 (7%)    1/60 (2%)    4/60 (7%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  19.2%        23.0%         7.7%        17.1%      |   7.4%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    2/13 (15%)   1/13 (8%)    3/21 (14%) |  2/27 (7%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   617          538          729 (T)      694       |   730 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.277N     P=0.581N     P=0.154N     P=0.381N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|INCIDENTAL TUMOR       |  P=0.388N     P=0.606N     P=0.152N     P=0.563N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|LOGISTIC REGRESSION    |  P=0.391N     P=0.587N     P=0.139N     P=0.504N   |  P=0.141N     P=0.274N     P=0.294N     P=0.294N   |
|COCHRAN-ARMITAGE       |  P=0.512N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.632N     P=0.177N     P=0.632N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE   9
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         7.7%         9.2%      |   0.0%         0.0%         4.8%         4.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    1/13 (8%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      456 (I)   |   ---          ---          730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.045 *      (e)        P=0.516      P=0.181    |  P=0.199        (e)        P=0.450      P=0.450    |
|INCIDENTAL TUMOR       |  P=0.022 *      (e)        P=0.516      P=0.105    |  P=0.199        (e)        P=0.450      P=0.450    |
|LOGISTIC REGRESSION    |  P=0.024 *      (e)        P=0.516      P=0.126    |  P=0.199        (e)        P=0.450      P=0.450    |
|COCHRAN-ARMITAGE       |  P=0.020 *                                         |  P=0.236                                           |
|FISHER EXACT           |                 (e)        P=0.500      P=0.122    |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    1/60 (2%)    3/60 (5%)  |  1/60 (2%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         7.7%         7.7%         9.2%      |   3.6%         0.0%         4.8%         4.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    1/13 (8%)    1/13 (8%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      729 (T)      456 (I)   |   724          ---          730 (T)      730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.115      P=0.516      P=0.516      P=0.181    |  P=0.474      P=0.531N     P=0.699      P=0.699    |
|INCIDENTAL TUMOR       |  P=0.074      P=0.516      P=0.516      P=0.105    |  P=0.482      P=0.511N     P=0.712      P=0.712    |
|LOGISTIC REGRESSION    |  P=0.067      P=0.516      P=0.516      P=0.126    |  P=0.483      P=0.529N     P=0.701      P=0.716    |
|COCHRAN-ARMITAGE       |  P=0.054                                           |  P=0.539                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.122    |               P=0.500N     P=0.752N     P=0.752N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  10
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  2/60 (3%)    2/60 (3%)    3/60 (5%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   7.0%         6.6%        11.0%         7.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  1/27 (4%)    1/23 (4%)    2/21 (10%)   1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   722          570          241          556       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.481      P=0.636      P=0.404      P=0.605    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.543      P=0.659      P=0.608      P=0.683    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.567      P=0.668      P=0.510      P=0.665    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.568                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.691N     P=0.500      P=0.691N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  3/60 (5%)    2/60 (3%)    3/60 (5%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   9.3%         6.6%        11.0%         7.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  1/27 (4%)    1/23 (4%)    2/21 (10%)   1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   667          570          241          556       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.546N     P=0.562N     P=0.554      P=0.596N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.491N     P=0.539N     P=0.601N     P=0.529N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.460N     P=0.531N     P=0.611N     P=0.534N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.457N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.660N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  11
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    4/60 (7%)    2/60 (3%)  | 22/60 (37%)  23/60 (38%)  26/60 (43%)  24/60 (40%) |
|ADJUSTED (b)           |  18.2%         5.6%        24.0%         8.6%      |  59.6%        57.8%        70.2%        61.4%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    1/13 (8%)    1/21 (5%)  | 13/27 (48%)   8/23 (35%)  11/21 (52%)   7/21 (33%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      710          709          710       |   566          457 (I)      379          483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.332N     P=0.282N     P=0.550      P=0.313N   |  P=0.177      P=0.304      P=0.073      P=0.198    |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.282N     P=0.561      P=0.364N   |  P=0.271      P=0.429      P=0.186      P=0.289    |
|LOGISTIC REGRESSION    |  P=0.430N     P=0.279N     P=0.574      P=0.427N   |  P=0.239      P=0.367      P=0.107      P=0.258    |
|COCHRAN-ARMITAGE       |  P=0.543N                                          |  P=0.369                                           |
|FISHER EXACT           |               P=0.309N     P=0.500      P=0.500N   |               P=0.500      P=0.288      P=0.426    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    4/60 (7%)    2/60 (3%)  | 23/60 (38%)  23/60 (38%)  26/60 (43%)  24/60 (40%) |
|ADJUSTED (b)           |  18.2%         5.6%        24.0%         8.6%      |  60.6%        57.8%        70.2%        61.4%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    1/13 (8%)    1/21 (5%)  | 13/27 (48%)   8/23 (35%)  11/21 (52%)   7/21 (33%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      710          709          710       |   566          457 (I)      379          483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.332N     P=0.282N     P=0.550      P=0.313N   |  P=0.213      P=0.364      P=0.099      P=0.247    |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.282N     P=0.561      P=0.364N   |  P=0.327      P=0.507      P=0.239      P=0.358    |
|LOGISTIC REGRESSION    |  P=0.430N     P=0.279N     P=0.574      P=0.427N   |  P=0.291      P=0.447      P=0.147      P=0.328    |
|COCHRAN-ARMITAGE       |  P=0.543N                                          |  P=0.429                                           |
|FISHER EXACT           |               P=0.309N     P=0.500      P=0.500N   |               P=0.574N     P=0.355      P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  12
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    1/60 (2%)    4/60 (7%)    2/60 (3%)  | 25/60 (42%)  25/60 (42%)  28/60 (47%)  26/60 (43%) |
|ADJUSTED (b)           |  18.2%         5.6%        24.0%         8.6%      |  64.7%        61.6%        73.6%        65.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   0/13 (0%)    1/13 (8%)    1/21 (5%)  | 14/27 (52%)   9/23 (39%)  12/21 (57%)   8/21 (38%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      710          709          710       |   566          457 (I)      241          483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.332N     P=0.282N     P=0.550      P=0.313N   |  P=0.202      P=0.349      P=0.093      P=0.229    |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.282N     P=0.561      P=0.364N   |  P=0.323      P=0.492      P=0.283      P=0.354    |
|LOGISTIC REGRESSION    |  P=0.430N     P=0.279N     P=0.574      P=0.427N   |  P=0.299      P=0.437      P=0.166      P=0.322    |
|COCHRAN-ARMITAGE       |  P=0.543N                                          |  P=0.430                                           |
|FISHER EXACT           |               P=0.309N     P=0.500      P=0.500N   |               P=0.573N     P=0.357      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.7%         0.0%        10.5%         4.8%      |   0.0%         0.0%         8.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    1/21 (5%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          ---          702          729 (T)   |   ---          ---          708          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.625N     P=0.475N     P=0.533      P=0.647N   |  P=0.558        (e)        P=0.186        (e)      |
|INCIDENTAL TUMOR       |  P=0.512      P=0.475N     P=0.565      P=0.718N   |  P=0.551        (e)        P=0.194        (e)      |
|LOGISTIC REGRESSION    |  P=0.596      P=0.471N     P=0.552      P=0.670N   |  P=0.560        (e)        P=0.183        (e)      |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.595                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.752N   |                 (e)        P=0.248        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  13
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.7%         0.0%        10.5%         4.8%      |   0.0%         0.0%         8.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    1/21 (5%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          ---          702          729 (T)   |   ---          ---          708          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.625N     P=0.475N     P=0.533      P=0.647N   |  P=0.558        (e)        P=0.186        (e)      |
|INCIDENTAL TUMOR       |  P=0.512      P=0.475N     P=0.565      P=0.718N   |  P=0.551        (e)        P=0.194        (e)      |
|LOGISTIC REGRESSION    |  P=0.596      P=0.471N     P=0.552      P=0.670N   |  P=0.560        (e)        P=0.183        (e)      |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.595                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.752N   |                 (e)        P=0.248        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    3/60 (5%)    0/59 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    1/59 (2%)    0/59 (0%)  |
|ADJUSTED (b)           |  16.7%        18.9%         0.0%         0.0%      |   0.0%         0.0%         4.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/12 (17%)   2/13 (15%)   0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      674          ---          ---       |   ---          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.032N*    P=0.538      P=0.217N     P=0.124N   |  P=0.662        (e)        P=0.450        (e)      |
|INCIDENTAL TUMOR       |  P=0.037N*    P=0.542      P=0.217N     P=0.124N   |  P=0.662        (e)        P=0.450        (e)      |
|LOGISTIC REGRESSION    |  P=0.040N*    P=0.571      P=0.217N     P=0.124N   |  P=0.662        (e)        P=0.450        (e)      |
|COCHRAN-ARMITAGE       |  P=0.072N                                          |  P=0.692                                           |
|FISHER EXACT           |               P=0.508      P=0.248N     P=0.244N   |                 (e)        P=0.496        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  14
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pharynx                                                                                                                          |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.7%         0.0%        10.5%         0.0%      |   0.0%         0.0%         4.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          ---          702          ---       |   ---          ---          708          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.362N     P=0.475N     P=0.533      P=0.415N   |  P=0.676        (e)        P=0.449        (e)      |
|INCIDENTAL TUMOR       |  P=0.500N     P=0.475N     P=0.565      P=0.529N   |  P=0.670        (e)        P=0.464        (e)      |
|LOGISTIC REGRESSION    |  P=0.388N     P=0.471N     P=0.552      P=0.430N   |  P=0.675        (e)        P=0.457        (e)      |
|COCHRAN-ARMITAGE       |  P=0.461N                                          |  P=0.694                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/59 (34%)  14/60 (23%)  20/59 (34%)  13/59 (22%) | 20/60 (33%)  29/60 (48%)  26/59 (44%)  26/59 (44%) |
|ADJUSTED (b)           |  80.0%        47.4%        59.9%        49.0%      |  48.4%        75.7%        76.9%        61.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   4/10 (40%)   1/10 (10%) |  2/10 (20%)   2/10 (20%)   1/9 (11%)    3/10 (30%) |
|TERMINAL (d)           |  8/12 (67%)   4/13 (31%)   4/13 (31%)   9/21 (43%) |  8/27 (30%)  15/23 (65%)  14/21 (67%)   7/20 (35%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      456 (I)      456 (I)   |   457 (I)      457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.019N*    P=0.112N     P=0.424N     P=0.005N** |  P=0.094      P=0.036 *    P=0.039 *    P=0.081    |
|INCIDENTAL TUMOR       |  P=0.096N     P=0.133N     P=0.457N     P=0.037N*  |  P=0.160      P=0.045 *    P=0.040 *    P=0.155    |
|LOGISTIC REGRESSION    |  P=0.098N     P=0.096N     P=0.441N     P=0.029N*  |  P=0.181      P=0.039 *    P=0.049 *    P=0.148    |
|COCHRAN-ARMITAGE       |  P=0.163N                                          |  P=0.230                                           |
|FISHER EXACT           |               P=0.142N     P=0.577N     P=0.109N   |               P=0.068      P=0.155      P=0.155    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  15
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/59 (34%)  14/60 (23%)  20/59 (34%)  13/59 (22%) | 21/60 (35%)  29/60 (48%)  26/59 (44%)  26/59 (44%) |
|ADJUSTED (b)           |  80.0%        47.4%        59.9%        49.0%      |  50.2%        75.7%        76.9%        61.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   4/10 (40%)   1/10 (10%) |  2/10 (20%)   2/10 (20%)   1/9 (11%)    3/10 (30%) |
|TERMINAL (d)           |  8/12 (67%)   4/13 (31%)   4/13 (31%)   9/21 (43%) |  8/27 (30%)  15/23 (65%)  14/21 (67%)   7/20 (35%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      456 (I)      456 (I)   |   457 (I)      457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.019N*    P=0.112N     P=0.424N     P=0.005N** |  P=0.117      P=0.052      P=0.054      P=0.106    |
|INCIDENTAL TUMOR       |  P=0.096N     P=0.133N     P=0.457N     P=0.037N*  |  P=0.199      P=0.065      P=0.058      P=0.201    |
|LOGISTIC REGRESSION    |  P=0.098N     P=0.096N     P=0.441N     P=0.029N*  |  P=0.223      P=0.057      P=0.070      P=0.165    |
|COCHRAN-ARMITAGE       |  P=0.163N                                          |  P=0.280                                           |
|FISHER EXACT           |               P=0.142N     P=0.577N     P=0.109N   |               P=0.097      P=0.205      P=0.205    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         6.7%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          687          694       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.136        (e)        P=0.529      P=0.367    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.046 *      (e)        P=0.536      P=0.205    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.093        (e)        P=0.527      P=0.290    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.070                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.500      P=0.248    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  16
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         6.7%      |   3.7%         0.0%         0.0%         1.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  1/27 (4%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          687          694       |   730 (T)      ---          ---          441       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.136        (e)        P=0.529      P=0.367    |  P=0.570      P=0.532N     P=0.550N     P=0.733    |
|INCIDENTAL TUMOR       |  P=0.046 *      (e)        P=0.536      P=0.205    |  P=0.685      P=0.532N     P=0.550N     P=0.623N   |
|LOGISTIC REGRESSION    |  P=0.093        (e)        P=0.527      P=0.290    |  P=0.608      P=0.532N     P=0.550N     P=0.738N   |
|COCHRAN-ARMITAGE       |  P=0.070                                           |  P=0.595                                           |
|FISHER EXACT           |                 (e)        P=0.500      P=0.248    |               P=0.500N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    5/60 (8%)    3/60 (5%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |  10.5%        10.5%        30.1%        10.1%      |   3.7%         0.0%         0.0%         6.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    3/13 (23%)   0/21 (0%)  |  1/27 (4%)    0/23 (0%)    0/21 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   505          631          687          694       |   730 (T)      ---          ---          441       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.386N     P=0.600N     P=0.433      P=0.482N   |  P=0.216      P=0.532N     P=0.550N     P=0.442    |
|INCIDENTAL TUMOR       |  P=0.518      P=0.661      P=0.408      P=0.602    |  P=0.277      P=0.532N     P=0.550N     P=0.627    |
|LOGISTIC REGRESSION    |  P=0.514N     P=0.640N     P=0.426      P=0.608N   |  P=0.246      P=0.532N     P=0.550N     P=0.509    |
|COCHRAN-ARMITAGE       |  P=0.537                                           |  P=0.246                                           |
|FISHER EXACT           |               P=0.660N     P=0.359      P=0.660N   |               P=0.500N     P=0.500N     P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  17
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    6/60 (10%)   4/60 (7%)    7/60 (12%) |  2/60 (3%)    1/60 (2%)    0/60 (0%)    3/60 (5%)  |
|ADJUSTED (b)           |  21.7%        28.3%        20.6%        21.2%      |   6.6%         3.1%         0.0%         9.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    2/13 (15%)   2/13 (15%)   1/21 (5%)  |  1/27 (4%)    0/23 (0%)    0/21 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   602          392          609          483       |   702          696          ---          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.509      P=0.441      P=0.583N     P=0.496    |  P=0.294      P=0.552N     P=0.295N     P=0.427    |
|INCIDENTAL TUMOR       |  P=0.261      P=0.412      P=0.588N     P=0.205    |  P=0.318      P=0.532N     P=0.288N     P=0.471    |
|LOGISTIC REGRESSION    |  P=0.330      P=0.423      P=0.570N     P=0.335    |  P=0.304      P=0.539N     P=0.291N     P=0.453    |
|COCHRAN-ARMITAGE       |  P=0.256                                           |  P=0.337                                           |
|FISHER EXACT           |               P=0.372      P=0.641N     P=0.264    |               P=0.500N     P=0.248N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   6/60 (10%)   4/60 (7%)   11/60 (18%) |  2/60 (3%)    1/60 (2%)    0/60 (0%)    3/60 (5%)  |
|ADJUSTED (b)           |  26.0%        28.3%        20.6%        32.5%      |   6.6%         3.1%         0.0%         9.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    2/13 (15%)   2/13 (15%)   2/21 (10%) |  1/27 (4%)    0/23 (0%)    0/21 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   451          392          609          483       |   702          696          ---          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.293      P=0.545N     P=0.312N     P=0.399    |  P=0.294      P=0.552N     P=0.295N     P=0.427    |
|INCIDENTAL TUMOR       |  P=0.081      P=0.574N     P=0.326N     P=0.093    |  P=0.318      P=0.532N     P=0.288N     P=0.471    |
|LOGISTIC REGRESSION    |  P=0.129      P=0.577N     P=0.307N     P=0.127    |  P=0.304      P=0.539N     P=0.291N     P=0.453    |
|COCHRAN-ARMITAGE       |  P=0.089                                           |  P=0.337                                           |
|FISHER EXACT           |               P=0.619N     P=0.372N     P=0.148    |               P=0.500N     P=0.248N     P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  18
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    0/60 (0%)    4/60 (7%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   3.7%         0.0%         0.0%        14.1%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    1/21 (5%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   645          ---          ---          615       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.065      P=0.479N     P=0.472N     P=0.319    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.020 *    P=0.475N     P=0.464N     P=0.149    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.039 *    P=0.488N     P=0.484N     P=0.236    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.028 *                                         |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.182    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    4/60 (7%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.5%         0.0%         0.0%        14.1%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    1/21 (5%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   451          ---          ---          615       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.181      P=0.222N     P=0.215N     P=0.500    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.086      P=0.226N     P=0.243N     P=0.293    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.116      P=0.253N     P=0.267N     P=0.374    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.104                                           |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.340    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  19
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    3/60 (5%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  10.5%        10.5%        19.4%         6.9%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    2/13 (15%)   0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   505          631          696          694       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.242N     P=0.600N     P=0.595N     P=0.350N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.430N     P=0.661      P=0.625N     P=0.563N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.326N     P=0.640N     P=0.610N     P=0.454N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.397N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.660N     P=0.660N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%        15.4%         0.0%      |   0.0%         0.0%         0.0%         4.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    2/13 (15%)   0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      ---       |   ---          ---          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.647N       (e)        P=0.253        (e)      |  P=0.176        (e)          (e)        P=0.450    |
|INCIDENTAL TUMOR       |  P=0.647N       (e)        P=0.253        (e)      |  P=0.176        (e)          (e)        P=0.450    |
|LOGISTIC REGRESSION    |  P=0.647N       (e)        P=0.253        (e)      |  P=0.176        (e)          (e)        P=0.450    |
|COCHRAN-ARMITAGE       |  P=0.595                                           |  P=0.199                                           |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  20
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    4/60 (7%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  10.5%        10.5%        26.7%         6.9%      |   0.0%         0.0%         0.0%         4.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    3/13 (23%)   0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   505          631          696          694       |   ---          ---          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.246N     P=0.600N     P=0.570      P=0.350N   |  P=0.176        (e)          (e)        P=0.450    |
|INCIDENTAL TUMOR       |  P=0.426N     P=0.661      P=0.544      P=0.563N   |  P=0.176        (e)          (e)        P=0.450    |
|LOGISTIC REGRESSION    |  P=0.338N     P=0.640N     P=0.568      P=0.454N   |  P=0.176        (e)          (e)        P=0.450    |
|COCHRAN-ARMITAGE       |  P=0.421N                                          |  P=0.199                                           |
|FISHER EXACT           |               P=0.660N     P=0.500      P=0.500N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    4/60 (7%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  10.5%        10.5%        26.7%         6.9%      |   0.0%         0.0%         0.0%         4.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    3/13 (23%)   0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   505          631          696          694       |   ---          ---          ---          730 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.246N     P=0.600N     P=0.570      P=0.350N   |  P=0.176        (e)          (e)        P=0.450    |
|INCIDENTAL TUMOR       |  P=0.426N     P=0.661      P=0.544      P=0.563N   |  P=0.176        (e)          (e)        P=0.450    |
|LOGISTIC REGRESSION    |  P=0.338N     P=0.640N     P=0.568      P=0.454N   |  P=0.176        (e)          (e)        P=0.450    |
|COCHRAN-ARMITAGE       |  P=0.421N                                          |  P=0.199                                           |
|FISHER EXACT           |               P=0.660N     P=0.500      P=0.500N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  21
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 53/60 (88%)  53/60 (88%)  53/59 (90%)  37/60 (62%) |                                                    |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%        92.0%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  9/10 (90%)   8/10 (80%)   9/10 (90%)   1/10 (10%) |                                                    |
|TERMINAL (d)           | 12/12 (100%) 13/13 (100%) 13/13 (100%) 18/21 (86%) |                                                    |
|FIRST INCIDENCE (DAYS) |   381          392          456 (I)      456 (I)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001N**   P=0.331N     P=0.297N     P<0.001N** |                                                    |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.478N     P=0.474N     P<0.001N** |                                                    |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.477N     P=0.542N     P<0.001N** |                                                    |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |                                                    |
|FISHER EXACT           |               P=0.611N     P=0.513      P<0.001N** |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Thymoma Benign                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/57 (2%)    1/59 (2%)    2/58 (3%)    0/56 (0%)  |  0/59 (0%)    0/58 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   8.3%         7.7%         3.7%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/9 (0%)     0/9 (0%)     1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    1/13 (8%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      456 (I)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.279N     P=0.747N     P=0.539      P=0.388N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.306N     P=0.747N     P=0.496      P=0.388N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.377N     P=0.747N     P=0.475      P=0.388N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.373N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.743N     P=0.507      P=0.504N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  22
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/59 (7%)    2/59 (3%)    2/59 (3%)    3/60 (5%)  |  9/60 (15%)   5/59 (8%)    5/60 (8%)    2/60 (3%)  |
|ADJUSTED (b)           |  19.0%         9.9%        15.4%        11.0%      |  29.3%        17.4%        15.1%         6.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    1/13 (8%)    2/13 (15%)   1/21 (5%)  |  7/27 (26%)   3/23 (13%)   1/21 (5%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   547          538          729 (T)      608       |   556          632          457 (I)      483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.290N     P=0.303N     P=0.297N     P=0.308N   |  P=0.053N     P=0.284N     P=0.347N     P=0.059N   |
|INCIDENTAL TUMOR       |  P=0.408N     P=0.324N     P=0.299N     P=0.541N   |  P=0.027N*    P=0.272N     P=0.311N     P=0.024N*  |
|LOGISTIC REGRESSION    |  P=0.396N     P=0.305N     P=0.277N     P=0.410N   |  P=0.032N*    P=0.263N     P=0.267N     P=0.039N*  |
|COCHRAN-ARMITAGE       |  P=0.471N                                          |  P=0.024N*                                         |
|FISHER EXACT           |               P=0.340N     P=0.340N     P=0.491N   |               P=0.207N     P=0.197N     P=0.027N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    1/59 (2%)    3/59 (5%)    1/60 (2%)  |  1/60 (2%)    0/59 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         7.7%        11.2%         2.9%      |   3.0%         0.0%         9.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    1/13 (8%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    2/21 (10%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      604          618       |   702          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.478      P=0.516      P=0.159      P=0.545    |  P=0.507N     P=0.540N     P=0.414      P=0.519N   |
|INCIDENTAL TUMOR       |  P=0.301      P=0.516      P=0.137      P=0.379    |  P=0.516N     P=0.523N     P=0.421      P=0.536N   |
|LOGISTIC REGRESSION    |  P=0.397      P=0.516      P=0.138      P=0.509    |  P=0.504N     P=0.523N     P=0.410      P=0.525N   |
|COCHRAN-ARMITAGE       |  P=0.357                                           |  P=0.459N                                          |
|FISHER EXACT           |               P=0.500      P=0.122      P=0.504    |               P=0.504N     P=0.500      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  23
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/59 (7%)    3/59 (5%)    5/59 (8%)    4/60 (7%)  | 10/60 (17%)   5/59 (8%)    7/60 (12%)   2/60 (3%)  |
|ADJUSTED (b)           |  19.0%        17.4%        24.9%        13.5%      |  31.4%        17.4%        23.6%         6.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  1/12 (8%)    2/13 (15%)   2/13 (15%)   1/21 (5%)  |  7/27 (26%)   3/23 (13%)   3/21 (14%)   1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   547          538          604          608       |   556          632          457 (I)      483       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.396N     P=0.456N     P=0.575      P=0.442N   |  P=0.048N*    P=0.213N     P=0.497N     P=0.038N*  |
|INCIDENTAL TUMOR       |  P=0.534      P=0.478N     P=0.554      P=0.568    |  P=0.026N*    P=0.197N     P=0.459N     P=0.015N*  |
|LOGISTIC REGRESSION    |  P=0.543N     P=0.454N     P=0.576      P=0.562N   |  P=0.029N*    P=0.189N     P=0.418N     P=0.023N*  |
|COCHRAN-ARMITAGE       |  P=0.511                                           |  P=0.020N*                                         |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.632N   |               P=0.142N     P=0.301N     P=0.015N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  5/60 (8%)   14/60 (23%)  15/60 (25%)   6/60 (10%) |
|ADJUSTED (b)           |                                                    |  15.9%        42.0%        41.0%        14.6%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    3/10 (30%)   3/10 (30%)   1/10 (10%) |
|TERMINAL (d)           |                                                    |  3/27 (11%)   7/23 (30%)   4/21 (19%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   490          457 (I)      434          457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.488      P=0.012 *    P=0.005 **   P=0.392    |
|INCIDENTAL TUMOR       |                                                    |  P=0.399N     P=0.028 *    P=0.021 *    P=0.619    |
|LOGISTIC REGRESSION    |                                                    |  P=0.448N     P=0.021 *    P=0.014 *    P=0.508    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.453N                                          |
|FISHER EXACT           |                                                    |               P=0.022 *    P=0.013 *    P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  24
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/60 (0%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         2.9%         4.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          694          457 (I)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.634N     P=0.489      P=0.219        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.575N     P=0.489      P=0.240        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.603N     P=0.483      P=0.322        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.616N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.248        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  5/60 (8%)   15/60 (25%)  17/60 (28%)   6/60 (10%) |
|ADJUSTED (b)           |                                                    |  15.9%        43.7%        43.6%        14.6%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    3/10 (30%)   4/10 (40%)   1/10 (10%) |
|TERMINAL (d)           |                                                    |  3/27 (11%)   7/23 (30%)   4/21 (19%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   490          457 (I)      434          457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.494      P=0.008 **   P=0.002 **   P=0.392    |
|INCIDENTAL TUMOR       |                                                    |  P=0.380N     P=0.017 *    P=0.007 **   P=0.619    |
|LOGISTIC REGRESSION    |                                                    |  P=0.433N     P=0.012 *    P=0.006 **   P=0.508    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.443N                                          |
|FISHER EXACT           |                                                    |               P=0.013 *    P=0.004 **   P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  25
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/60 (2%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   2.4%         0.0%         4.9%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   667          ---          538          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.494N     P=0.515N     P=0.426      P=0.526N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.335N     P=0.511N     P=0.678      P=0.536N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.448N     P=0.508N     P=0.545      P=0.509N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.461N                                          |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.500      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.5%         0.0%         0.0%         0.0%      |   0.0%         0.0%         2.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   381          ---          ---          ---       |   ---          ---          647          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.110N     P=0.229N     P=0.219N     P=0.229N   |  P=0.665        (e)        P=0.455        (e)      |
|INCIDENTAL TUMOR       |  P=0.141N     P=0.262N     P=0.264N     P=0.318N   |  P=0.670        (e)        P=0.464        (e)      |
|LOGISTIC REGRESSION    |  P=0.138N     P=0.289N     P=0.342N     P=0.272N   |  P=0.692        (e)        P=0.494        (e)      |
|COCHRAN-ARMITAGE       |  P=0.115N                                          |  P=0.694                                           |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.248N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  26
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         4.3%      |   0.0%         0.0%         4.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          456 (I)   |   ---          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.054        (e)          (e)        P=0.266    |  P=0.662        (e)        P=0.450        (e)      |
|INCIDENTAL TUMOR       |  P=0.030 *      (e)          (e)        P=0.175    |  P=0.662        (e)        P=0.450        (e)      |
|LOGISTIC REGRESSION    |  P=0.042 *      (e)          (e)        P=0.213    |  P=0.662        (e)        P=0.450        (e)      |
|COCHRAN-ARMITAGE       |  P=0.046 *                                         |  P=0.694                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/60 (48%)  36/60 (60%)  26/60 (43%)   2/60 (3%)  | 17/60 (28%)  12/60 (20%)   3/60 (5%)    0/60 (0%)  |
|ADJUSTED (b)           |  76.2%        80.1%        76.3%         4.5%      |  38.6%        33.7%         8.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/12 (33%)   5/13 (38%)   7/13 (54%)   0/21 (0%)  |  3/27 (11%)   4/23 (17%)   0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   503          415          506          445       |   490          457 (I)      492          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001N**   P=0.375      P=0.215N     P<0.001N** |  P<0.001N**   P=0.343N     P=0.008N**   P<0.001N** |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.117      P=0.219N     P<0.001N** |  P<0.001N**   P=0.200N     P<0.001N**   P<0.001N** |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.154      P=0.125N     P<0.001N** |  P<0.001N**   P=0.214N     P<0.001N**   P<0.001N** |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.136      P=0.357N     P<0.001N** |               P=0.197N     P<0.001N**   P<0.001N** |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  27
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         4.3%      |   0.0%         0.0%         4.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    1/21 (5%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          456 (I)   |   ---          ---          730 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.054        (e)          (e)        P=0.266    |  P=0.662        (e)        P=0.450        (e)      |
|INCIDENTAL TUMOR       |  P=0.030 *      (e)          (e)        P=0.175    |  P=0.662        (e)        P=0.450        (e)      |
|LOGISTIC REGRESSION    |  P=0.042 *      (e)          (e)        P=0.213    |  P=0.662        (e)        P=0.450        (e)      |
|COCHRAN-ARMITAGE       |  P=0.046 *                                         |  P=0.694                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%        13.1%        11.2%         3.1%      |   0.0%         0.0%         0.0%         4.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    1/13 (8%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          722          702          681       |   ---          ---          ---          714       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.613N     P=0.270      P=0.267      P=0.604    |  P=0.177        (e)          (e)        P=0.447    |
|INCIDENTAL TUMOR       |  P=0.468      P=0.263      P=0.278      P=0.471    |  P=0.179        (e)          (e)        P=0.464    |
|LOGISTIC REGRESSION    |  P=0.577      P=0.272      P=0.269      P=0.539    |  P=0.186        (e)          (e)        P=0.469    |
|COCHRAN-ARMITAGE       |  P=0.470                                           |  P=0.199                                           |
|FISHER EXACT           |               P=0.248      P=0.248      P=0.500    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  28
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |  1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         6.3%         2.5%         2.9%      |   2.0%         1.7%         4.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          591          570          618       |   556          441          709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.553      P=0.266      P=0.538      P=0.545    |  P=0.339N     P=0.744      P=0.701      P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.371      P=0.231      P=0.500      P=0.379    |  P=0.204N     P=0.605N     P=0.740      P=0.388N   |
|LOGISTIC REGRESSION    |  P=0.502      P=0.246      P=0.483      P=0.506    |  P=0.291N     P=0.683N     P=0.763N     P=0.467N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.312N                                          |
|FISHER EXACT           |               P=0.248      P=0.500      P=0.500    |               P=0.752N     P=0.752N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |  1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         6.3%         2.5%         2.9%      |   2.0%         1.7%         4.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/12 (0%)    0/13 (0%)    0/13 (0%)    0/21 (0%)  |  0/27 (0%)    0/23 (0%)    0/21 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          591          570          618       |   556          441          709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.553      P=0.266      P=0.538      P=0.545    |  P=0.339N     P=0.744      P=0.701      P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.371      P=0.231      P=0.500      P=0.379    |  P=0.204N     P=0.605N     P=0.740      P=0.388N   |
|LOGISTIC REGRESSION    |  P=0.502      P=0.246      P=0.483      P=0.506    |  P=0.291N     P=0.683N     P=0.763N     P=0.467N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.312N                                          |
|FISHER EXACT           |               P=0.248      P=0.500      P=0.500    |               P=0.752N     P=0.752N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  29
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 56/60 (93%)  57/60 (95%)  58/60 (97%)  45/60 (75%) | 42/60 (70%)  46/60 (77%)  48/60 (80%)  45/60 (75%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%        97.8%      |  85.4%        93.6%        95.9%        89.6%      |
|INTERIM SACRIFICE 1 (c)|  9/10 (90%)   9/10 (90%)  10/10 (100%)  4/10 (40%) |  2/10 (20%)   5/10 (50%)   4/10 (40%)   4/10 (40%) |
|TERMINAL (d)           | 12/12 (100%) 13/13 (100%) 13/13 (100%) 20/21 (95%) | 20/27 (74%)  20/23 (87%)  19/21 (90%)  16/21 (76%) |
|FIRST INCIDENCE (DAYS) |   381          392          456 (I)      456 (I)   |   457 (I)      457 (I)      379          457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001N**   P=0.369N     P=0.371N     P<0.001N** |  P=0.104      P=0.116      P=0.022 *    P=0.104    |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.696      P=0.671N     P<0.001N** |  P=0.228      P=0.152      P=0.033 *    P=0.269    |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.592N     P=0.687N     P<0.001N** |  P=0.237      P=0.116      P=0.016 *    P=0.256    |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.333                                           |
|FISHER EXACT           |               P=0.500      P=0.340      P=0.005N** |               P=0.268      P=0.146      P=0.342    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 39/60 (65%)  39/60 (65%)  34/60 (57%)  20/60 (33%) | 21/60 (35%)  20/60 (33%)  22/60 (37%)  10/60 (17%) |
|ADJUSTED (b)           |  84.3%        83.4%        83.2%        51.0%      |  46.6%        48.8%        59.4%        28.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    1/10 (10%) |  0/10 (0%)    1/10 (10%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  5/12 (42%)   6/13 (46%)   7/13 (54%)   5/21 (24%) |  5/27 (19%)   6/23 (26%)   9/21 (43%)   2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   381          310          506          445       |   490          150          241          441       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001N**   P=0.362N     P=0.144N     P<0.001N** |  P=0.090N     P=0.465      P=0.222      P=0.092N   |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.584N     P=0.072N     P<0.001N** |  P=0.005N**   P=0.420N     P=0.458N     P=0.003N** |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.464N     P=0.045N*    P<0.001N** |  P=0.016N*    P=0.518N     P=0.452      P=0.010N** |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.015N*                                         |
|FISHER EXACT           |               P=0.576N     P=0.227N     P<0.001N** |               P=0.500N     P=0.500      P=0.018N*  |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 05155 TEST: 03                                                 PAGE  30
                           STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.125%       0.25%        0.5%      |   0.0%         0.125%       0.25%        0.5%      |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 57/60 (95%)  59/60 (98%)  59/60 (98%)  50/60 (83%) | 46/60 (77%)  53/60 (88%)  55/60 (92%)  49/60 (82%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  88.4%        98.1%       100.0%        92.4%      |
|INTERIM SACRIFICE 1 (c)|  9/10 (90%)   9/10 (90%)  10/10 (100%)  4/10 (40%) |  2/10 (20%)   5/10 (50%)   5/10 (50%)   4/10 (40%) |
|TERMINAL (d)           | 12/12 (100%) 13/13 (100%) 13/13 (100%) 21/21 (100%)| 21/27 (78%)  22/23 (96%)  21/21 (100%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) |   381          310          456 (I)      445       |   457 (I)      150          241          441       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001N**   P=0.414N     P=0.365N     P=0.002N** |  P=0.114      P=0.054      P=0.008 **   P=0.096    |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.421      P=0.736N     P=0.004N** |  P=0.359      P=0.036 *    P=0.011 *    P=0.338    |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.535      P=0.601N     P<0.001N** |  P=0.250      P=0.019 *    P=0.002 **   P=0.288    |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.370                                           |
|FISHER EXACT           |               P=0.309      P=0.309      P=0.037N*  |               P=0.074      P=0.022 *    P=0.327    |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).