TDMS Study 05155-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROBENZOIC ACID DATE: 05/08/95
EXPERIMENT: 05155 TEST: 03 TIME: 17:13:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85217 ROUTE: DOSED FEED NTP C#: 61778B
PATHOLOGIST: DR D. FARNELL HAILEY, JAMES R. CAS: 62-23-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROBENZOIC ACID DATE: 05/08/95
EXPERIMENT: 05155 TEST: 03 TIME: 17:13:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85217 ROUTE: DOSED FEED NTP C#: 61778B
PATHOLOGIST: DR D. FARNELL HAILEY, JAMES R. CAS: 62-23-7
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROBENZOIC ACID DATE: 05/08/95
EXPERIMENT: 05155 TEST: 03 TIME: 17:13:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85217 ROUTE: DOSED FEED NTP C#: 61778B
PATHOLOGIST: DR D. FARNELL HAILEY, JAMES R. CAS: 62-23-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF P-NITROBENZOIC ACID
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Islets, Pancreatic Carcinoma or Adenoma
Lung Alveolar/Bronchiolar Adenoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma
Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,
malignant or NOS), or Trichoepithelioma
Fibrosarcoma
Testes Adenoma
All Organs Histiocytic Sarcoma
Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Malignant Lymphoma And Histiocytic Sarcoma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 11/60 (18%) 8/60 (13%) 12/60 (20%) | 2/59 (3%) 1/60 (2%) 3/60 (5%) 0/60 (0%) |
|ADJUSTED (b) | 44.4% 57.2% 34.5% 42.6% | 5.4% 4.3% 11.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/12 (25%) 6/13 (46%) 3/13 (23%) 6/21 (29%) | 0/26 (0%) 1/23 (4%) 2/21 (10%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 631 591 456 (I) 608 | 647 730 (T) 518 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264N P=0.580N P=0.316N P=0.339N | P=0.298N P=0.557N P=0.402 P=0.289N |
|INCIDENTAL TUMOR | P=0.538N P=0.580 P=0.315N P=0.508 | P=0.236N P=0.528N P=0.578 P=0.278N |
|LOGISTIC REGRESSION | P=0.486N P=0.583N P=0.298N P=0.500 | P=0.259N P=0.523N P=0.467 P=0.248N |
|COCHRAN-ARMITAGE | P=0.397 | P=0.238N |
|FISHER EXACT | P=0.500 P=0.399N P=0.407 | P=0.494N P=0.508 P=0.244N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 2/60 (3%) | 0/59 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 16.7% 0.0% 3.6% 7.7% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/26 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 672 703 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.603N P=0.217N P=0.463N P=0.499N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.521 P=0.217N P=0.460N P=0.622N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.572 P=0.217N P=0.448N P=0.555N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.470 | (e) |
|FISHER EXACT | P=0.248N P=0.500N P=0.691N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 11/60 (18%) 9/60 (15%) 13/60 (22%) | 2/59 (3%) 1/60 (2%) 3/60 (5%) 0/60 (0%) |
|ADJUSTED (b) | 50.6% 57.2% 36.8% 44.8% | 5.4% 4.3% 11.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 6/13 (46%) 3/13 (23%) 6/21 (29%) | 0/26 (0%) 1/23 (4%) 2/21 (10%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 631 591 456 (I) 608 | 647 730 (T) 518 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271N P=0.483N P=0.313N P=0.303N | P=0.298N P=0.557N P=0.402 P=0.289N |
|INCIDENTAL TUMOR | P=0.531 P=0.518N P=0.309N P=0.529 | P=0.236N P=0.528N P=0.578 P=0.278N |
|LOGISTIC REGRESSION | P=0.503N P=0.472N P=0.291N P=0.531 | P=0.259N P=0.523N P=0.467 P=0.248N |
|COCHRAN-ARMITAGE | P=0.368 | P=0.238N |
|FISHER EXACT | P=0.593N P=0.404N P=0.410 | P=0.494N P=0.508 P=0.244N |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 6.3% 2.5% 2.9% | 2.0% 1.7% 4.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 591 570 618 | 556 441 709 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.266 P=0.538 P=0.545 | P=0.339N P=0.744 P=0.701 P=0.526N |
|INCIDENTAL TUMOR | P=0.371 P=0.231 P=0.500 P=0.379 | P=0.204N P=0.605N P=0.740 P=0.388N |
|LOGISTIC REGRESSION | P=0.502 P=0.246 P=0.483 P=0.506 | P=0.291N P=0.683N P=0.763N P=0.467N |
|COCHRAN-ARMITAGE | P=0.500 | P=0.312N |
|FISHER EXACT | P=0.248 P=0.500 P=0.500 | P=0.752N P=0.752N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/60 (5%) 5/59 (8%) 4/60 (7%) | 4/60 (7%) 12/59 (20%) 10/59 (17%) 12/60 (20%) |
|ADJUSTED (b) | 22.5% 13.6% 17.9% 12.0% | 11.9% 42.5% 33.7% 42.1% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 1/13 (8%) 1/21 (5%) | 2/27 (7%) 7/22 (32%) 4/20 (20%) 7/21 (33%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 588 456 (I) 456 (I) | 653 665 496 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.441N P=0.444N P=0.549 P=0.443N | P=0.034 * P=0.013 * P=0.030 * P=0.013 * |
|INCIDENTAL TUMOR | P=0.515 P=0.474N P=0.539 P=0.590N | P=0.038 * P=0.013 * P=0.049 * P=0.022 * |
|LOGISTIC REGRESSION | P=0.537 P=0.457N P=0.525 P=0.604N | P=0.039 * P=0.012 * P=0.038 * P=0.017 * |
|COCHRAN-ARMITAGE | P=0.499 | P=0.069 |
|FISHER EXACT | P=0.500N P=0.489 P=0.641N | P=0.026 * P=0.072 P=0.029 * |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 4/59 (7%) 6/60 (10%) | 1/60 (2%) 2/59 (3%) 5/59 (8%) 4/60 (7%) |
|ADJUSTED (b) | 2.7% 2.9% 15.9% 15.0% | 3.7% 6.0% 19.3% 11.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 1/27 (4%) 0/22 (0%) 3/20 (15%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 548 602 651 518 | 730 (T) 694 499 528 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031 * P=0.744N P=0.234 P=0.094 | P=0.085 P=0.460 P=0.056 P=0.139 |
|INCIDENTAL TUMOR | P=0.004 ** P=0.720 P=0.216 P=0.026 * | P=0.131 P=0.463 P=0.099 P=0.267 |
|LOGISTIC REGRESSION | P=0.002 ** P=0.756 P=0.204 P=0.009 ** | P=0.104 P=0.453 P=0.071 P=0.173 |
|COCHRAN-ARMITAGE | P=0.014 * | P=0.117 |
|FISHER EXACT | P=0.752N P=0.177 P=0.057 | P=0.494 P=0.100 P=0.182 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 4/60 (7%) 9/59 (15%) 10/60 (17%) | 4/60 (7%) 14/59 (24%) 15/59 (25%) 15/60 (25%) |
|ADJUSTED (b) | 24.6% 16.1% 30.9% 25.1% | 11.9% 45.9% 48.9% 47.7% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 1/13 (8%) 1/21 (5%) | 2/27 (7%) 7/22 (32%) 7/20 (35%) 7/21 (33%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 588 456 (I) 456 (I) | 653 665 496 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164 P=0.441N P=0.270 P=0.292 | P=0.008 ** P=0.005 ** P=0.001 ** P=0.002 ** |
|INCIDENTAL TUMOR | P=0.031 * P=0.504N P=0.246 P=0.106 | P=0.009 ** P=0.004 ** P=0.003 ** P=0.005 ** |
|LOGISTIC REGRESSION | P=0.029 * P=0.465N P=0.227 P=0.075 | P=0.009 ** P=0.003 ** P=0.002 ** P=0.003 ** |
|COCHRAN-ARMITAGE | P=0.051 | P=0.020 * |
|FISHER EXACT | P=0.500N P=0.188 P=0.135 | P=0.009 ** P=0.005 ** P=0.005 ** |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 13.2% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 689 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.079N P=0.215N P=0.220N P=0.134N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.094N P=0.218N P=0.211N P=0.193N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.089N P=0.206N P=0.204N P=0.169N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.115N | (e) |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 13.2% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 689 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.079N P=0.215N P=0.220N P=0.134N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.094N P=0.218N P=0.211N P=0.193N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.089N P=0.206N P=0.204N P=0.169N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.115N | (e) |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 1/60 (2%) 2/59 (3%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) 0/59 (0%) 0/59 (0%) |
|ADJUSTED (b) | 14.4% 3.0% 13.1% 0.0% | 3.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/13 (0%) 1/13 (8%) 0/21 (0%) | 1/27 (4%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 714 624 709 --- | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.122N P=0.458N P=0.668N P=0.140N | P=0.338N P=0.532N P=0.550N P=0.550N |
|INCIDENTAL TUMOR | P=0.179N P=0.499N P=0.647N P=0.193N | P=0.338N P=0.532N P=0.550N P=0.550N |
|LOGISTIC REGRESSION | P=0.144N P=0.459N P=0.647N P=0.148N | P=0.338N P=0.532N P=0.550N P=0.550N |
|COCHRAN-ARMITAGE | P=0.198N | P=0.308N |
|FISHER EXACT | P=0.494N P=0.691N P=0.244N | P=0.500N P=0.504N P=0.504N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/59 (5%) 1/60 (2%) 2/59 (3%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) 0/59 (0%) 0/59 (0%) |
|ADJUSTED (b) | 22.2% 3.0% 13.1% 0.0% | 3.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 1/13 (8%) 0/21 (0%) | 1/27 (4%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 714 624 709 --- | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.052N P=0.268N P=0.467N P=0.048N* | P=0.338N P=0.532N P=0.550N P=0.550N |
|INCIDENTAL TUMOR | P=0.078N P=0.299N P=0.444N P=0.069N | P=0.338N P=0.532N P=0.550N P=0.550N |
|LOGISTIC REGRESSION | P=0.064N P=0.259N P=0.434N P=0.052N | P=0.338N P=0.532N P=0.550N P=0.550N |
|COCHRAN-ARMITAGE | P=0.103N | P=0.308N |
|FISHER EXACT | P=0.303N P=0.500N P=0.119N | P=0.500N P=0.504N P=0.504N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 9.8% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 1/13 (8%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 541 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.657 (e) P=0.259 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.638 (e) P=0.224 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.607 (e) P=0.251 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.595 | (e) |
|FISHER EXACT | (e) P=0.248 (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 4/60 (7%) 1/60 (2%) 2/60 (3%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 11.7% 23.0% 7.7% 7.9% | 7.4% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/13 (15%) 1/13 (8%) 1/21 (5%) | 2/27 (7%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 645 538 729 (T) 694 | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.242N P=0.386 P=0.465N P=0.513N | P=0.141N P=0.274N P=0.294N P=0.294N |
|INCIDENTAL TUMOR | P=0.312N P=0.384 P=0.460N P=0.622N | P=0.141N P=0.274N P=0.294N P=0.294N |
|LOGISTIC REGRESSION | P=0.328N P=0.388 P=0.448N P=0.598N | P=0.141N P=0.274N P=0.294N P=0.294N |
|COCHRAN-ARMITAGE | P=0.426N | P=0.115N |
|FISHER EXACT | P=0.348 P=0.494N P=0.684N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/59 (5%) 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 11.8% 0.0% 0.0% 9.5% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 2/21 (10%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 617 --- --- 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396N P=0.104N P=0.104N P=0.324N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.501N P=0.118N P=0.101N P=0.480N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.466N P=0.107N P=0.103N P=0.408N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.526N | (e) |
|FISHER EXACT | P=0.119N P=0.119N P=0.492N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/59 (7%) 4/60 (7%) 1/60 (2%) 4/60 (7%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 19.2% 23.0% 7.7% 17.1% | 7.4% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/13 (15%) 1/13 (8%) 3/21 (14%) | 2/27 (7%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 617 538 729 (T) 694 | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.581N P=0.154N P=0.381N | P=0.141N P=0.274N P=0.294N P=0.294N |
|INCIDENTAL TUMOR | P=0.388N P=0.606N P=0.152N P=0.563N | P=0.141N P=0.274N P=0.294N P=0.294N |
|LOGISTIC REGRESSION | P=0.391N P=0.587N P=0.139N P=0.504N | P=0.141N P=0.274N P=0.294N P=0.294N |
|COCHRAN-ARMITAGE | P=0.512N | P=0.115N |
|FISHER EXACT | P=0.632N P=0.177N P=0.632N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/59 (7%) 4/60 (7%) 1/60 (2%) 4/60 (7%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 19.2% 23.0% 7.7% 17.1% | 7.4% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/13 (15%) 1/13 (8%) 3/21 (14%) | 2/27 (7%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 617 538 729 (T) 694 | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.581N P=0.154N P=0.381N | P=0.141N P=0.274N P=0.294N P=0.294N |
|INCIDENTAL TUMOR | P=0.388N P=0.606N P=0.152N P=0.563N | P=0.141N P=0.274N P=0.294N P=0.294N |
|LOGISTIC REGRESSION | P=0.391N P=0.587N P=0.139N P=0.504N | P=0.141N P=0.274N P=0.294N P=0.294N |
|COCHRAN-ARMITAGE | P=0.512N | P=0.115N |
|FISHER EXACT | P=0.632N P=0.177N P=0.632N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 7.7% 9.2% | 0.0% 0.0% 4.8% 4.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 1/13 (8%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) 456 (I) | --- --- 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045 * (e) P=0.516 P=0.181 | P=0.199 (e) P=0.450 P=0.450 |
|INCIDENTAL TUMOR | P=0.022 * (e) P=0.516 P=0.105 | P=0.199 (e) P=0.450 P=0.450 |
|LOGISTIC REGRESSION | P=0.024 * (e) P=0.516 P=0.126 | P=0.199 (e) P=0.450 P=0.450 |
|COCHRAN-ARMITAGE | P=0.020 * | P=0.236 |
|FISHER EXACT | (e) P=0.500 P=0.122 | (e) P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 3/60 (5%) | 1/60 (2%) 0/60 (0%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 7.7% 7.7% 9.2% | 3.6% 0.0% 4.8% 4.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/13 (8%) 1/13 (8%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) 456 (I) | 724 --- 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115 P=0.516 P=0.516 P=0.181 | P=0.474 P=0.531N P=0.699 P=0.699 |
|INCIDENTAL TUMOR | P=0.074 P=0.516 P=0.516 P=0.105 | P=0.482 P=0.511N P=0.712 P=0.712 |
|LOGISTIC REGRESSION | P=0.067 P=0.516 P=0.516 P=0.126 | P=0.483 P=0.529N P=0.701 P=0.716 |
|COCHRAN-ARMITAGE | P=0.054 | P=0.539 |
|FISHER EXACT | P=0.500 P=0.500 P=0.122 | P=0.500N P=0.752N P=0.752N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 2/60 (3%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.0% 6.6% 11.0% 7.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 1/27 (4%) 1/23 (4%) 2/21 (10%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 722 570 241 556 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.481 P=0.636 P=0.404 P=0.605 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.543 P=0.659 P=0.608 P=0.683 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.567 P=0.668 P=0.510 P=0.665 |
|COCHRAN-ARMITAGE | (e) | P=0.568 |
|FISHER EXACT | (e) (e) (e) | P=0.691N P=0.500 P=0.691N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 3/60 (5%) 2/60 (3%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 9.3% 6.6% 11.0% 7.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 1/27 (4%) 1/23 (4%) 2/21 (10%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 667 570 241 556 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.546N P=0.562N P=0.554 P=0.596N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.491N P=0.539N P=0.601N P=0.529N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.460N P=0.531N P=0.611N P=0.534N |
|COCHRAN-ARMITAGE | (e) | P=0.457N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.660N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 4/60 (7%) 2/60 (3%) | 22/60 (37%) 23/60 (38%) 26/60 (43%) 24/60 (40%) |
|ADJUSTED (b) | 18.2% 5.6% 24.0% 8.6% | 59.6% 57.8% 70.2% 61.4% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 1/13 (8%) 1/21 (5%) | 13/27 (48%) 8/23 (35%) 11/21 (52%) 7/21 (33%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 710 709 710 | 566 457 (I) 379 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.282N P=0.550 P=0.313N | P=0.177 P=0.304 P=0.073 P=0.198 |
|INCIDENTAL TUMOR | P=0.463N P=0.282N P=0.561 P=0.364N | P=0.271 P=0.429 P=0.186 P=0.289 |
|LOGISTIC REGRESSION | P=0.430N P=0.279N P=0.574 P=0.427N | P=0.239 P=0.367 P=0.107 P=0.258 |
|COCHRAN-ARMITAGE | P=0.543N | P=0.369 |
|FISHER EXACT | P=0.309N P=0.500 P=0.500N | P=0.500 P=0.288 P=0.426 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 4/60 (7%) 2/60 (3%) | 23/60 (38%) 23/60 (38%) 26/60 (43%) 24/60 (40%) |
|ADJUSTED (b) | 18.2% 5.6% 24.0% 8.6% | 60.6% 57.8% 70.2% 61.4% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 1/13 (8%) 1/21 (5%) | 13/27 (48%) 8/23 (35%) 11/21 (52%) 7/21 (33%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 710 709 710 | 566 457 (I) 379 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.282N P=0.550 P=0.313N | P=0.213 P=0.364 P=0.099 P=0.247 |
|INCIDENTAL TUMOR | P=0.463N P=0.282N P=0.561 P=0.364N | P=0.327 P=0.507 P=0.239 P=0.358 |
|LOGISTIC REGRESSION | P=0.430N P=0.279N P=0.574 P=0.427N | P=0.291 P=0.447 P=0.147 P=0.328 |
|COCHRAN-ARMITAGE | P=0.543N | P=0.429 |
|FISHER EXACT | P=0.309N P=0.500 P=0.500N | P=0.574N P=0.355 P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 4/60 (7%) 2/60 (3%) | 25/60 (42%) 25/60 (42%) 28/60 (47%) 26/60 (43%) |
|ADJUSTED (b) | 18.2% 5.6% 24.0% 8.6% | 64.7% 61.6% 73.6% 65.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/13 (0%) 1/13 (8%) 1/21 (5%) | 14/27 (52%) 9/23 (39%) 12/21 (57%) 8/21 (38%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 710 709 710 | 566 457 (I) 241 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.282N P=0.550 P=0.313N | P=0.202 P=0.349 P=0.093 P=0.229 |
|INCIDENTAL TUMOR | P=0.463N P=0.282N P=0.561 P=0.364N | P=0.323 P=0.492 P=0.283 P=0.354 |
|LOGISTIC REGRESSION | P=0.430N P=0.279N P=0.574 P=0.427N | P=0.299 P=0.437 P=0.166 P=0.322 |
|COCHRAN-ARMITAGE | P=0.543N | P=0.430 |
|FISHER EXACT | P=0.309N P=0.500 P=0.500N | P=0.573N P=0.357 P=0.500 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 6.7% 0.0% 10.5% 4.8% | 0.0% 0.0% 8.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 1/21 (5%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 714 --- 702 729 (T) | --- --- 708 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.625N P=0.475N P=0.533 P=0.647N | P=0.558 (e) P=0.186 (e) |
|INCIDENTAL TUMOR | P=0.512 P=0.475N P=0.565 P=0.718N | P=0.551 (e) P=0.194 (e) |
|LOGISTIC REGRESSION | P=0.596 P=0.471N P=0.552 P=0.670N | P=0.560 (e) P=0.183 (e) |
|COCHRAN-ARMITAGE | P=0.500 | P=0.595 |
|FISHER EXACT | P=0.500N P=0.500 P=0.752N | (e) P=0.248 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 6.7% 0.0% 10.5% 4.8% | 0.0% 0.0% 8.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 1/21 (5%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 714 --- 702 729 (T) | --- --- 708 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.625N P=0.475N P=0.533 P=0.647N | P=0.558 (e) P=0.186 (e) |
|INCIDENTAL TUMOR | P=0.512 P=0.475N P=0.565 P=0.718N | P=0.551 (e) P=0.194 (e) |
|LOGISTIC REGRESSION | P=0.596 P=0.471N P=0.552 P=0.670N | P=0.560 (e) P=0.183 (e) |
|COCHRAN-ARMITAGE | P=0.500 | P=0.595 |
|FISHER EXACT | P=0.500N P=0.500 P=0.752N | (e) P=0.248 (e) |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 3/60 (5%) 0/59 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 0/59 (0%) |
|ADJUSTED (b) | 16.7% 18.9% 0.0% 0.0% | 0.0% 0.0% 4.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 2/13 (15%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 674 --- --- | --- --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.032N* P=0.538 P=0.217N P=0.124N | P=0.662 (e) P=0.450 (e) |
|INCIDENTAL TUMOR | P=0.037N* P=0.542 P=0.217N P=0.124N | P=0.662 (e) P=0.450 (e) |
|LOGISTIC REGRESSION | P=0.040N* P=0.571 P=0.217N P=0.124N | P=0.662 (e) P=0.450 (e) |
|COCHRAN-ARMITAGE | P=0.072N | P=0.692 |
|FISHER EXACT | P=0.508 P=0.248N P=0.244N | (e) P=0.496 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Pharynx |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 6.7% 0.0% 10.5% 0.0% | 0.0% 0.0% 4.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 714 --- 702 --- | --- --- 708 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.362N P=0.475N P=0.533 P=0.415N | P=0.676 (e) P=0.449 (e) |
|INCIDENTAL TUMOR | P=0.500N P=0.475N P=0.565 P=0.529N | P=0.670 (e) P=0.464 (e) |
|LOGISTIC REGRESSION | P=0.388N P=0.471N P=0.552 P=0.430N | P=0.675 (e) P=0.457 (e) |
|COCHRAN-ARMITAGE | P=0.461N | P=0.694 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/59 (34%) 14/60 (23%) 20/59 (34%) 13/59 (22%) | 20/60 (33%) 29/60 (48%) 26/59 (44%) 26/59 (44%) |
|ADJUSTED (b) | 80.0% 47.4% 59.9% 49.0% | 48.4% 75.7% 76.9% 61.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/10 (20%) 4/10 (40%) 1/10 (10%) | 2/10 (20%) 2/10 (20%) 1/9 (11%) 3/10 (30%) |
|TERMINAL (d) | 8/12 (67%) 4/13 (31%) 4/13 (31%) 9/21 (43%) | 8/27 (30%) 15/23 (65%) 14/21 (67%) 7/20 (35%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019N* P=0.112N P=0.424N P=0.005N** | P=0.094 P=0.036 * P=0.039 * P=0.081 |
|INCIDENTAL TUMOR | P=0.096N P=0.133N P=0.457N P=0.037N* | P=0.160 P=0.045 * P=0.040 * P=0.155 |
|LOGISTIC REGRESSION | P=0.098N P=0.096N P=0.441N P=0.029N* | P=0.181 P=0.039 * P=0.049 * P=0.148 |
|COCHRAN-ARMITAGE | P=0.163N | P=0.230 |
|FISHER EXACT | P=0.142N P=0.577N P=0.109N | P=0.068 P=0.155 P=0.155 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/59 (34%) 14/60 (23%) 20/59 (34%) 13/59 (22%) | 21/60 (35%) 29/60 (48%) 26/59 (44%) 26/59 (44%) |
|ADJUSTED (b) | 80.0% 47.4% 59.9% 49.0% | 50.2% 75.7% 76.9% 61.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/10 (20%) 4/10 (40%) 1/10 (10%) | 2/10 (20%) 2/10 (20%) 1/9 (11%) 3/10 (30%) |
|TERMINAL (d) | 8/12 (67%) 4/13 (31%) 4/13 (31%) 9/21 (43%) | 8/27 (30%) 15/23 (65%) 14/21 (67%) 7/20 (35%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019N* P=0.112N P=0.424N P=0.005N** | P=0.117 P=0.052 P=0.054 P=0.106 |
|INCIDENTAL TUMOR | P=0.096N P=0.133N P=0.457N P=0.037N* | P=0.199 P=0.065 P=0.058 P=0.201 |
|LOGISTIC REGRESSION | P=0.098N P=0.096N P=0.441N P=0.029N* | P=0.223 P=0.057 P=0.070 P=0.165 |
|COCHRAN-ARMITAGE | P=0.163N | P=0.280 |
|FISHER EXACT | P=0.142N P=0.577N P=0.109N | P=0.097 P=0.205 P=0.205 |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 6.7% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 687 694 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.136 (e) P=0.529 P=0.367 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.046 * (e) P=0.536 P=0.205 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.093 (e) P=0.527 P=0.290 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.070 | (e) |
|FISHER EXACT | (e) P=0.500 P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 2/60 (3%) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 6.7% | 3.7% 0.0% 0.0% 1.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 1/27 (4%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 687 694 | 730 (T) --- --- 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.136 (e) P=0.529 P=0.367 | P=0.570 P=0.532N P=0.550N P=0.733 |
|INCIDENTAL TUMOR | P=0.046 * (e) P=0.536 P=0.205 | P=0.685 P=0.532N P=0.550N P=0.623N |
|LOGISTIC REGRESSION | P=0.093 (e) P=0.527 P=0.290 | P=0.608 P=0.532N P=0.550N P=0.738N |
|COCHRAN-ARMITAGE | P=0.070 | P=0.595 |
|FISHER EXACT | (e) P=0.500 P=0.248 | P=0.500N P=0.500N P=0.752N |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 5/60 (8%) 3/60 (5%) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 10.5% 10.5% 30.1% 10.1% | 3.7% 0.0% 0.0% 6.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 3/13 (23%) 0/21 (0%) | 1/27 (4%) 0/23 (0%) 0/21 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 505 631 687 694 | 730 (T) --- --- 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.386N P=0.600N P=0.433 P=0.482N | P=0.216 P=0.532N P=0.550N P=0.442 |
|INCIDENTAL TUMOR | P=0.518 P=0.661 P=0.408 P=0.602 | P=0.277 P=0.532N P=0.550N P=0.627 |
|LOGISTIC REGRESSION | P=0.514N P=0.640N P=0.426 P=0.608N | P=0.246 P=0.532N P=0.550N P=0.509 |
|COCHRAN-ARMITAGE | P=0.537 | P=0.246 |
|FISHER EXACT | P=0.660N P=0.359 P=0.660N | P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 6/60 (10%) 4/60 (7%) 7/60 (12%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 3/60 (5%) |
|ADJUSTED (b) | 21.7% 28.3% 20.6% 21.2% | 6.6% 3.1% 0.0% 9.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/13 (15%) 2/13 (15%) 1/21 (5%) | 1/27 (4%) 0/23 (0%) 0/21 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 602 392 609 483 | 702 696 --- 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.509 P=0.441 P=0.583N P=0.496 | P=0.294 P=0.552N P=0.295N P=0.427 |
|INCIDENTAL TUMOR | P=0.261 P=0.412 P=0.588N P=0.205 | P=0.318 P=0.532N P=0.288N P=0.471 |
|LOGISTIC REGRESSION | P=0.330 P=0.423 P=0.570N P=0.335 | P=0.304 P=0.539N P=0.291N P=0.453 |
|COCHRAN-ARMITAGE | P=0.256 | P=0.337 |
|FISHER EXACT | P=0.372 P=0.641N P=0.264 | P=0.500N P=0.248N P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 6/60 (10%) 4/60 (7%) 11/60 (18%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 3/60 (5%) |
|ADJUSTED (b) | 26.0% 28.3% 20.6% 32.5% | 6.6% 3.1% 0.0% 9.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/13 (15%) 2/13 (15%) 2/21 (10%) | 1/27 (4%) 0/23 (0%) 0/21 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 451 392 609 483 | 702 696 --- 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293 P=0.545N P=0.312N P=0.399 | P=0.294 P=0.552N P=0.295N P=0.427 |
|INCIDENTAL TUMOR | P=0.081 P=0.574N P=0.326N P=0.093 | P=0.318 P=0.532N P=0.288N P=0.471 |
|LOGISTIC REGRESSION | P=0.129 P=0.577N P=0.307N P=0.127 | P=0.304 P=0.539N P=0.291N P=0.453 |
|COCHRAN-ARMITAGE | P=0.089 | P=0.337 |
|FISHER EXACT | P=0.619N P=0.372N P=0.148 | P=0.500N P=0.248N P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 4/60 (7%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.7% 0.0% 0.0% 14.1% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 1/21 (5%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 645 --- --- 615 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065 P=0.479N P=0.472N P=0.319 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.020 * P=0.475N P=0.464N P=0.149 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.039 * P=0.488N P=0.484N P=0.236 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.028 * | (e) |
|FISHER EXACT | P=0.500N P=0.500N P=0.182 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 4/60 (7%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.5% 0.0% 0.0% 14.1% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 1/21 (5%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 451 --- --- 615 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181 P=0.222N P=0.215N P=0.500 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.086 P=0.226N P=0.243N P=0.293 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.116 P=0.253N P=0.267N P=0.374 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.104 | (e) |
|FISHER EXACT | P=0.248N P=0.248N P=0.340 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 3/60 (5%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 10.5% 10.5% 19.4% 6.9% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 2/13 (15%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 505 631 696 694 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.242N P=0.600N P=0.595N P=0.350N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.430N P=0.661 P=0.625N P=0.563N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.326N P=0.640N P=0.610N P=0.454N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.397N | (e) |
|FISHER EXACT | P=0.660N P=0.660N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 15.4% 0.0% | 0.0% 0.0% 0.0% 4.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 2/13 (15%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- | --- --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.647N (e) P=0.253 (e) | P=0.176 (e) (e) P=0.450 |
|INCIDENTAL TUMOR | P=0.647N (e) P=0.253 (e) | P=0.176 (e) (e) P=0.450 |
|LOGISTIC REGRESSION | P=0.647N (e) P=0.253 (e) | P=0.176 (e) (e) P=0.450 |
|COCHRAN-ARMITAGE | P=0.595 | P=0.199 |
|FISHER EXACT | (e) P=0.248 (e) | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 4/60 (7%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 10.5% 10.5% 26.7% 6.9% | 0.0% 0.0% 0.0% 4.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 3/13 (23%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 505 631 696 694 | --- --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246N P=0.600N P=0.570 P=0.350N | P=0.176 (e) (e) P=0.450 |
|INCIDENTAL TUMOR | P=0.426N P=0.661 P=0.544 P=0.563N | P=0.176 (e) (e) P=0.450 |
|LOGISTIC REGRESSION | P=0.338N P=0.640N P=0.568 P=0.454N | P=0.176 (e) (e) P=0.450 |
|COCHRAN-ARMITAGE | P=0.421N | P=0.199 |
|FISHER EXACT | P=0.660N P=0.500 P=0.500N | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 4/60 (7%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 10.5% 10.5% 26.7% 6.9% | 0.0% 0.0% 0.0% 4.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 3/13 (23%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 505 631 696 694 | --- --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246N P=0.600N P=0.570 P=0.350N | P=0.176 (e) (e) P=0.450 |
|INCIDENTAL TUMOR | P=0.426N P=0.661 P=0.544 P=0.563N | P=0.176 (e) (e) P=0.450 |
|LOGISTIC REGRESSION | P=0.338N P=0.640N P=0.568 P=0.454N | P=0.176 (e) (e) P=0.450 |
|COCHRAN-ARMITAGE | P=0.421N | P=0.199 |
|FISHER EXACT | P=0.660N P=0.500 P=0.500N | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 53/60 (88%) 53/60 (88%) 53/59 (90%) 37/60 (62%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 92.0% | |
|INTERIM SACRIFICE 1 (c)| 9/10 (90%) 8/10 (80%) 9/10 (90%) 1/10 (10%) | |
|TERMINAL (d) | 12/12 (100%) 13/13 (100%) 13/13 (100%) 18/21 (86%) | |
|FIRST INCIDENCE (DAYS) | 381 392 456 (I) 456 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.331N P=0.297N P<0.001N** | |
|INCIDENTAL TUMOR | P<0.001N** P=0.478N P=0.474N P<0.001N** | |
|LOGISTIC REGRESSION | P<0.001N** P=0.477N P=0.542N P<0.001N** | |
|COCHRAN-ARMITAGE | P<0.001N** | |
|FISHER EXACT | P=0.611N P=0.513 P<0.001N** | |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/57 (2%) 1/59 (2%) 2/58 (3%) 0/56 (0%) | 0/59 (0%) 0/58 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 8.3% 7.7% 3.7% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/9 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 1/13 (8%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 456 (I) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.279N P=0.747N P=0.539 P=0.388N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.306N P=0.747N P=0.496 P=0.388N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.377N P=0.747N P=0.475 P=0.388N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.373N | (e) |
|FISHER EXACT | P=0.743N P=0.507 P=0.504N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/59 (7%) 2/59 (3%) 2/59 (3%) 3/60 (5%) | 9/60 (15%) 5/59 (8%) 5/60 (8%) 2/60 (3%) |
|ADJUSTED (b) | 19.0% 9.9% 15.4% 11.0% | 29.3% 17.4% 15.1% 6.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 1/13 (8%) 2/13 (15%) 1/21 (5%) | 7/27 (26%) 3/23 (13%) 1/21 (5%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 547 538 729 (T) 608 | 556 632 457 (I) 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.290N P=0.303N P=0.297N P=0.308N | P=0.053N P=0.284N P=0.347N P=0.059N |
|INCIDENTAL TUMOR | P=0.408N P=0.324N P=0.299N P=0.541N | P=0.027N* P=0.272N P=0.311N P=0.024N* |
|LOGISTIC REGRESSION | P=0.396N P=0.305N P=0.277N P=0.410N | P=0.032N* P=0.263N P=0.267N P=0.039N* |
|COCHRAN-ARMITAGE | P=0.471N | P=0.024N* |
|FISHER EXACT | P=0.340N P=0.340N P=0.491N | P=0.207N P=0.197N P=0.027N* |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 1/59 (2%) 3/59 (5%) 1/60 (2%) | 1/60 (2%) 0/59 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 7.7% 11.2% 2.9% | 3.0% 0.0% 9.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/13 (8%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 2/21 (10%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 604 618 | 702 --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478 P=0.516 P=0.159 P=0.545 | P=0.507N P=0.540N P=0.414 P=0.519N |
|INCIDENTAL TUMOR | P=0.301 P=0.516 P=0.137 P=0.379 | P=0.516N P=0.523N P=0.421 P=0.536N |
|LOGISTIC REGRESSION | P=0.397 P=0.516 P=0.138 P=0.509 | P=0.504N P=0.523N P=0.410 P=0.525N |
|COCHRAN-ARMITAGE | P=0.357 | P=0.459N |
|FISHER EXACT | P=0.500 P=0.122 P=0.504 | P=0.504N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/59 (7%) 3/59 (5%) 5/59 (8%) 4/60 (7%) | 10/60 (17%) 5/59 (8%) 7/60 (12%) 2/60 (3%) |
|ADJUSTED (b) | 19.0% 17.4% 24.9% 13.5% | 31.4% 17.4% 23.6% 6.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/13 (15%) 2/13 (15%) 1/21 (5%) | 7/27 (26%) 3/23 (13%) 3/21 (14%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 547 538 604 608 | 556 632 457 (I) 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396N P=0.456N P=0.575 P=0.442N | P=0.048N* P=0.213N P=0.497N P=0.038N* |
|INCIDENTAL TUMOR | P=0.534 P=0.478N P=0.554 P=0.568 | P=0.026N* P=0.197N P=0.459N P=0.015N* |
|LOGISTIC REGRESSION | P=0.543N P=0.454N P=0.576 P=0.562N | P=0.029N* P=0.189N P=0.418N P=0.023N* |
|COCHRAN-ARMITAGE | P=0.511 | P=0.020N* |
|FISHER EXACT | P=0.500N P=0.500 P=0.632N | P=0.142N P=0.301N P=0.015N* |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/60 (8%) 14/60 (23%) 15/60 (25%) 6/60 (10%) |
|ADJUSTED (b) | | 15.9% 42.0% 41.0% 14.6% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 3/10 (30%) 3/10 (30%) 1/10 (10%) |
|TERMINAL (d) | | 3/27 (11%) 7/23 (30%) 4/21 (19%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | | 490 457 (I) 434 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.488 P=0.012 * P=0.005 ** P=0.392 |
|INCIDENTAL TUMOR | | P=0.399N P=0.028 * P=0.021 * P=0.619 |
|LOGISTIC REGRESSION | | P=0.448N P=0.021 * P=0.014 * P=0.508 |
|COCHRAN-ARMITAGE | | P=0.453N |
|FISHER EXACT | | P=0.022 * P=0.013 * P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 1/60 (2%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 2.9% 4.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 694 457 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.634N P=0.489 P=0.219 (e) |
|INCIDENTAL TUMOR | | P=0.575N P=0.489 P=0.240 (e) |
|LOGISTIC REGRESSION | | P=0.603N P=0.483 P=0.322 (e) |
|COCHRAN-ARMITAGE | | P=0.616N |
|FISHER EXACT | | P=0.500 P=0.248 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/60 (8%) 15/60 (25%) 17/60 (28%) 6/60 (10%) |
|ADJUSTED (b) | | 15.9% 43.7% 43.6% 14.6% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 3/10 (30%) 4/10 (40%) 1/10 (10%) |
|TERMINAL (d) | | 3/27 (11%) 7/23 (30%) 4/21 (19%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | | 490 457 (I) 434 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.494 P=0.008 ** P=0.002 ** P=0.392 |
|INCIDENTAL TUMOR | | P=0.380N P=0.017 * P=0.007 ** P=0.619 |
|LOGISTIC REGRESSION | | P=0.433N P=0.012 * P=0.006 ** P=0.508 |
|COCHRAN-ARMITAGE | | P=0.443N |
|FISHER EXACT | | P=0.013 * P=0.004 ** P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 2.4% 0.0% 4.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | | 667 --- 538 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.494N P=0.515N P=0.426 P=0.526N |
|INCIDENTAL TUMOR | | P=0.335N P=0.511N P=0.678 P=0.536N |
|LOGISTIC REGRESSION | | P=0.448N P=0.508N P=0.545 P=0.509N |
|COCHRAN-ARMITAGE | | P=0.461N |
|FISHER EXACT | | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 4.5% 0.0% 0.0% 0.0% | 0.0% 0.0% 2.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 381 --- --- --- | --- --- 647 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.110N P=0.229N P=0.219N P=0.229N | P=0.665 (e) P=0.455 (e) |
|INCIDENTAL TUMOR | P=0.141N P=0.262N P=0.264N P=0.318N | P=0.670 (e) P=0.464 (e) |
|LOGISTIC REGRESSION | P=0.138N P=0.289N P=0.342N P=0.272N | P=0.692 (e) P=0.494 (e) |
|COCHRAN-ARMITAGE | P=0.115N | P=0.694 |
|FISHER EXACT | P=0.248N P=0.248N P=0.248N | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 4.3% | 0.0% 0.0% 4.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 456 (I) | --- --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 (e) (e) P=0.266 | P=0.662 (e) P=0.450 (e) |
|INCIDENTAL TUMOR | P=0.030 * (e) (e) P=0.175 | P=0.662 (e) P=0.450 (e) |
|LOGISTIC REGRESSION | P=0.042 * (e) (e) P=0.213 | P=0.662 (e) P=0.450 (e) |
|COCHRAN-ARMITAGE | P=0.046 * | P=0.694 |
|FISHER EXACT | (e) (e) P=0.248 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 29/60 (48%) 36/60 (60%) 26/60 (43%) 2/60 (3%) | 17/60 (28%) 12/60 (20%) 3/60 (5%) 0/60 (0%) |
|ADJUSTED (b) | 76.2% 80.1% 76.3% 4.5% | 38.6% 33.7% 8.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 5/13 (38%) 7/13 (54%) 0/21 (0%) | 3/27 (11%) 4/23 (17%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 503 415 506 445 | 490 457 (I) 492 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.375 P=0.215N P<0.001N** | P<0.001N** P=0.343N P=0.008N** P<0.001N** |
|INCIDENTAL TUMOR | P<0.001N** P=0.117 P=0.219N P<0.001N** | P<0.001N** P=0.200N P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION | P<0.001N** P=0.154 P=0.125N P<0.001N** | P<0.001N** P=0.214N P<0.001N** P<0.001N** |
|COCHRAN-ARMITAGE | P<0.001N** | P<0.001N** |
|FISHER EXACT | P=0.136 P=0.357N P<0.001N** | P=0.197N P<0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 4.3% | 0.0% 0.0% 4.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 1/21 (5%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 456 (I) | --- --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 (e) (e) P=0.266 | P=0.662 (e) P=0.450 (e) |
|INCIDENTAL TUMOR | P=0.030 * (e) (e) P=0.175 | P=0.662 (e) P=0.450 (e) |
|LOGISTIC REGRESSION | P=0.042 * (e) (e) P=0.213 | P=0.662 (e) P=0.450 (e) |
|COCHRAN-ARMITAGE | P=0.046 * | P=0.694 |
|FISHER EXACT | (e) (e) P=0.248 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 13.1% 11.2% 3.1% | 0.0% 0.0% 0.0% 4.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/13 (8%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 722 702 681 | --- --- --- 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613N P=0.270 P=0.267 P=0.604 | P=0.177 (e) (e) P=0.447 |
|INCIDENTAL TUMOR | P=0.468 P=0.263 P=0.278 P=0.471 | P=0.179 (e) (e) P=0.464 |
|LOGISTIC REGRESSION | P=0.577 P=0.272 P=0.269 P=0.539 | P=0.186 (e) (e) P=0.469 |
|COCHRAN-ARMITAGE | P=0.470 | P=0.199 |
|FISHER EXACT | P=0.248 P=0.248 P=0.500 | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 6.3% 2.5% 2.9% | 2.0% 1.7% 4.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 591 570 618 | 556 441 709 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.266 P=0.538 P=0.545 | P=0.339N P=0.744 P=0.701 P=0.526N |
|INCIDENTAL TUMOR | P=0.371 P=0.231 P=0.500 P=0.379 | P=0.204N P=0.605N P=0.740 P=0.388N |
|LOGISTIC REGRESSION | P=0.502 P=0.246 P=0.483 P=0.506 | P=0.291N P=0.683N P=0.763N P=0.467N |
|COCHRAN-ARMITAGE | P=0.500 | P=0.312N |
|FISHER EXACT | P=0.248 P=0.500 P=0.500 | P=0.752N P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 6.3% 2.5% 2.9% | 2.0% 1.7% 4.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/13 (0%) 0/21 (0%) | 0/27 (0%) 0/23 (0%) 0/21 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 591 570 618 | 556 441 709 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.266 P=0.538 P=0.545 | P=0.339N P=0.744 P=0.701 P=0.526N |
|INCIDENTAL TUMOR | P=0.371 P=0.231 P=0.500 P=0.379 | P=0.204N P=0.605N P=0.740 P=0.388N |
|LOGISTIC REGRESSION | P=0.502 P=0.246 P=0.483 P=0.506 | P=0.291N P=0.683N P=0.763N P=0.467N |
|COCHRAN-ARMITAGE | P=0.500 | P=0.312N |
|FISHER EXACT | P=0.248 P=0.500 P=0.500 | P=0.752N P=0.752N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 56/60 (93%) 57/60 (95%) 58/60 (97%) 45/60 (75%) | 42/60 (70%) 46/60 (77%) 48/60 (80%) 45/60 (75%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 97.8% | 85.4% 93.6% 95.9% 89.6% |
|INTERIM SACRIFICE 1 (c)| 9/10 (90%) 9/10 (90%) 10/10 (100%) 4/10 (40%) | 2/10 (20%) 5/10 (50%) 4/10 (40%) 4/10 (40%) |
|TERMINAL (d) | 12/12 (100%) 13/13 (100%) 13/13 (100%) 20/21 (95%) | 20/27 (74%) 20/23 (87%) 19/21 (90%) 16/21 (76%) |
|FIRST INCIDENCE (DAYS) | 381 392 456 (I) 456 (I) | 457 (I) 457 (I) 379 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.369N P=0.371N P<0.001N** | P=0.104 P=0.116 P=0.022 * P=0.104 |
|INCIDENTAL TUMOR | P<0.001N** P=0.696 P=0.671N P<0.001N** | P=0.228 P=0.152 P=0.033 * P=0.269 |
|LOGISTIC REGRESSION | P<0.001N** P=0.592N P=0.687N P<0.001N** | P=0.237 P=0.116 P=0.016 * P=0.256 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.333 |
|FISHER EXACT | P=0.500 P=0.340 P=0.005N** | P=0.268 P=0.146 P=0.342 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 39/60 (65%) 39/60 (65%) 34/60 (57%) 20/60 (33%) | 21/60 (35%) 20/60 (33%) 22/60 (37%) 10/60 (17%) |
|ADJUSTED (b) | 84.3% 83.4% 83.2% 51.0% | 46.6% 48.8% 59.4% 28.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 6/13 (46%) 7/13 (54%) 5/21 (24%) | 5/27 (19%) 6/23 (26%) 9/21 (43%) 2/21 (10%) |
|FIRST INCIDENCE (DAYS) | 381 310 506 445 | 490 150 241 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.362N P=0.144N P<0.001N** | P=0.090N P=0.465 P=0.222 P=0.092N |
|INCIDENTAL TUMOR | P<0.001N** P=0.584N P=0.072N P<0.001N** | P=0.005N** P=0.420N P=0.458N P=0.003N** |
|LOGISTIC REGRESSION | P<0.001N** P=0.464N P=0.045N* P<0.001N** | P=0.016N* P=0.518N P=0.452 P=0.010N** |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.015N* |
|FISHER EXACT | P=0.576N P=0.227N P<0.001N** | P=0.500N P=0.500 P=0.018N* |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 05155 TEST: 03 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- P-NITROBENZOIC ACID
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.125% 0.25% 0.5% | 0.0% 0.125% 0.25% 0.5% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 57/60 (95%) 59/60 (98%) 59/60 (98%) 50/60 (83%) | 46/60 (77%) 53/60 (88%) 55/60 (92%) 49/60 (82%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 88.4% 98.1% 100.0% 92.4% |
|INTERIM SACRIFICE 1 (c)| 9/10 (90%) 9/10 (90%) 10/10 (100%) 4/10 (40%) | 2/10 (20%) 5/10 (50%) 5/10 (50%) 4/10 (40%) |
|TERMINAL (d) | 12/12 (100%) 13/13 (100%) 13/13 (100%) 21/21 (100%)| 21/27 (78%) 22/23 (96%) 21/21 (100%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 381 310 456 (I) 445 | 457 (I) 150 241 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001N** P=0.414N P=0.365N P=0.002N** | P=0.114 P=0.054 P=0.008 ** P=0.096 |
|INCIDENTAL TUMOR | P<0.001N** P=0.421 P=0.736N P=0.004N** | P=0.359 P=0.036 * P=0.011 * P=0.338 |
|LOGISTIC REGRESSION | P<0.001N** P=0.535 P=0.601N P<0.001N** | P=0.250 P=0.019 * P=0.002 ** P=0.288 |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.370 |
|FISHER EXACT | P=0.309 P=0.309 P=0.037N* | P=0.074 P=0.022 * P=0.327 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 457
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).