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TDMS Study 05156-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/03/96       
EXPERIMENT: 05156 TEST: 06                                                                                     TIME: 11:13:03       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: MELLICK, P.                                                                                       CAS: 10026-24-1      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/03/96       
EXPERIMENT: 05156 TEST: 06                                                                                     TIME: 11:13:03       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: MELLICK, P.                                                                                       CAS: 10026-24-1      


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/03/96       
EXPERIMENT: 05156 TEST: 06                                                                                     TIME: 11:13:03       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: MELLICK, P.                                                                                       CAS: 10026-24-1      


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                 IN THE ANALYSIS OF THE STUDY OF 1  COBALT SULFATE HEPTAHYDRATE
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Liver                         Hemangiosarcoma
                                            Hepatoblastoma
                                            Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              All Organs                    Hemangiosarcoma
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Liver                         Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Skin                          Sarcoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
              All Organs                    Histiocytic Sarcoma
              ====================================================================================================
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   1
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         5.9%         0.0%         5.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    1/31 (3%)    0/24 (0%)    1/20 (5%)  |  0/34 (0%)    0/37 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          687          ---          733 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.553      P=0.320        (e)        P=0.481    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.541      P=0.267        (e)        P=0.481    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.560      P=0.275        (e)        P=0.481    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.625                                           |    (e)                                             |
|FISHER EXACT           |               P=0.253        (e)        P=0.505    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    2/50 (4%)    1/50 (2%)  |  2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  13.2%         6.5%         8.3%         4.5%      |   5.9%         5.4%         0.0%         3.6%      |
|TERMINAL (d)           |  1/22 (5%)    2/31 (6%)    2/24 (8%)    0/20 (0%)  |  2/34 (6%)    2/37 (5%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   600          733 (T)      733 (T)      686       |   734 (T)      734 (T)      ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.270N     P=0.221N     P=0.306N     P=0.239N   |  P=0.459N     P=0.665N     P=0.252N     P=0.568N   |
|INCIDENTAL TUMOR       |  P=0.235N     P=0.308N     P=0.317N     P=0.242N   |  P=0.459N     P=0.665N     P=0.252N     P=0.568N   |
|LOGISTIC REGRESSION    |  P=0.229N     P=0.307N     P=0.324N     P=0.192N   |  P=0.459N     P=0.665N     P=0.252N     P=0.568N   |
|COCHRAN-ARMITAGE       |  P=0.185N                                          |  P=0.382N                                          |
|FISHER EXACT           |               P=0.339N     P=0.339N     P=0.181N   |               P=0.691N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   2
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/50 (8%)    8/50 (16%)   7/50 (14%) |  1/50 (2%)    0/50 (0%)    3/50 (6%)    0/49 (0%)  |
|ADJUSTED (b)           |   9.1%        11.5%        23.5%        25.0%      |   2.9%         0.0%         7.3%         0.0%      |
|TERMINAL (d)           |  2/22 (9%)    2/31 (6%)    2/24 (8%)    3/20 (15%) |  1/34 (3%)    0/37 (0%)    1/32 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      685          523          502       |   734 (T)      ---          524          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.036 *    P=0.500      P=0.071      P=0.064    |  P=0.499N     P=0.483N     P=0.298      P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.088      P=0.431      P=0.051      P=0.087    |  P=0.364N     P=0.483N     P=0.319      P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.078      P=0.441      P=0.050 *    P=0.069    |  P=0.431N     P=0.483N     P=0.318      P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.096                                           |  P=0.455N                                          |
|FISHER EXACT           |               P=0.339      P=0.046 *    P=0.080    |               P=0.500N     P=0.309      P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    0/50 (0%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  11.8%         0.0%         7.6%        10.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/22 (5%)    0/31 (0%)    1/24 (4%)    2/20 (10%) |  0/34 (0%)    0/37 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   533          ---          705          733 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.596      P=0.043N*    P=0.313N     P=0.390N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.582N     P=0.103N     P=0.346N     P=0.353N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.567N     P=0.095N     P=0.342N     P=0.345N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.549N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.059N     P=0.339N     P=0.339N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   3
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/50 (44%)  21/50 (42%)  25/50 (50%)  13/50 (26%) |  8/50 (16%)  10/50 (20%)  13/50 (26%)  12/49 (24%) |
|ADJUSTED (b)           |  71.4%        57.5%        74.0%        42.3%      |  22.9%        25.0%        34.0%        35.3%      |
|TERMINAL (d)           | 14/22 (64%)  16/31 (52%)  16/24 (67%)   5/20 (25%) |  7/34 (21%)   8/37 (22%)   8/32 (25%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |   470          614          440          533       |   713          593          622          539       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.192N     P=0.102N     P=0.473      P=0.123N   |  P=0.103      P=0.480      P=0.150      P=0.128    |
|INCIDENTAL TUMOR       |  P=0.044N*    P=0.265N     P=0.380      P=0.065N   |  P=0.147      P=0.451      P=0.189      P=0.159    |
|LOGISTIC REGRESSION    |  P=0.061N     P=0.290N     P=0.389      P=0.067N   |  P=0.174      P=0.466      P=0.152      P=0.180    |
|COCHRAN-ARMITAGE       |  P=0.026N*                                         |  P=0.221                                           |
|FISHER EXACT           |               P=0.500N     P=0.344      P=0.046N*  |               P=0.398      P=0.163      P=0.212    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/50 (46%)  33/50 (66%)  30/50 (60%)  30/50 (60%) | 12/50 (24%)   9/50 (18%)  16/50 (32%)   4/49 (8%)  |
|ADJUSTED (b)           |  60.8%        69.5%        66.5%        71.2%      |  31.7%        22.7%        40.5%        11.8%      |
|TERMINAL (d)           |  9/22 (41%)  17/31 (55%)  10/24 (42%)   9/20 (45%) |  9/34 (26%)   7/37 (19%)   9/32 (28%)   1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   482          460          440          502       |   609          666          640          667       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.074      P=0.398      P=0.262      P=0.094    |  P=0.094N     P=0.240N     P=0.235      P=0.063N   |
|INCIDENTAL TUMOR       |  P=0.520      P=0.014 *    P=0.090      P=0.173    |  P=0.049N*    P=0.290N     P=0.263      P=0.039N*  |
|LOGISTIC REGRESSION    |  P=0.471      P=0.017 *    P=0.097      P=0.143    |  P=0.051N     P=0.258N     P=0.238      P=0.037N*  |
|COCHRAN-ARMITAGE       |  P=0.303                                           |  P=0.036N*                                         |
|FISHER EXACT           |               P=0.035 *    P=0.115      P=0.115    |               P=0.312N     P=0.252      P=0.030N*  |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   4
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/50 (54%)  33/50 (66%)  31/50 (62%)  31/50 (62%) | 12/50 (24%)   9/50 (18%)  16/50 (32%)   4/49 (8%)  |
|ADJUSTED (b)           |  66.6%        69.5%        67.7%        73.8%      |  31.7%        22.7%        40.5%        11.8%      |
|TERMINAL (d)           | 10/22 (45%)  17/31 (55%)  10/24 (42%)  10/20 (50%) |  9/34 (26%)   7/37 (19%)   9/32 (28%)   1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   482          460          440          502       |   609          666          640          667       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.106      P=0.458N     P=0.436      P=0.190    |  P=0.094N     P=0.240N     P=0.235      P=0.063N   |
|INCIDENTAL TUMOR       |  P=0.458N     P=0.064      P=0.223      P=0.365    |  P=0.049N*    P=0.290N     P=0.263      P=0.039N*  |
|LOGISTIC REGRESSION    |  P=0.500N     P=0.062      P=0.221      P=0.328    |  P=0.051N     P=0.258N     P=0.238      P=0.037N*  |
|COCHRAN-ARMITAGE       |  P=0.414                                           |  P=0.036N*                                         |
|FISHER EXACT           |               P=0.154      P=0.272      P=0.272    |               P=0.312N     P=0.252      P=0.030N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 38/50 (76%)  41/50 (82%)  43/50 (86%)  38/50 (76%) | 18/50 (36%)  18/50 (36%)  24/50 (48%)  16/49 (33%) |
|ADJUSTED (b)           |  89.8%        85.2%        93.2%        83.9%      |  48.1%        43.3%        56.7%        43.8%      |
|TERMINAL (d)           | 18/22 (82%)  24/31 (77%)  21/24 (88%)  13/20 (65%) | 15/34 (44%)  14/37 (38%)  14/32 (44%)   9/28 (32%) |
|FIRST INCIDENCE (DAYS) |   470          460          440          502       |   609          593          622          539       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.134      P=0.161N     P=0.425      P=0.338    |  P=0.444      P=0.451N     P=0.145      P=0.530    |
|INCIDENTAL TUMOR       |  P=0.255N     P=0.273      P=0.145      P=0.482N   |  P=0.523N     P=0.549N     P=0.150      P=0.560N   |
|LOGISTIC REGRESSION    |  P=0.375N     P=0.284      P=0.155      P=0.591    |  P=0.474N     P=0.488N     P=0.137      P=0.506N   |
|COCHRAN-ARMITAGE       |  P=0.399N                                          |  P=0.374N                                          |
|FISHER EXACT           |               P=0.312      P=0.154      P=0.592N   |               P=0.582N     P=0.156      P=0.445N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   5
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/50 (80%)  41/50 (82%)  44/50 (88%)  39/50 (78%) | 18/50 (36%)  18/50 (36%)  24/50 (48%)  16/49 (33%) |
|ADJUSTED (b)           |  90.3%        85.2%        93.5%        86.2%      |  48.1%        43.3%        56.7%        43.8%      |
|TERMINAL (d)           | 18/22 (82%)  24/31 (77%)  21/24 (88%)  14/20 (70%) | 15/34 (44%)  14/37 (38%)  14/32 (44%)   9/28 (32%) |
|FIRST INCIDENCE (DAYS) |   470          460          440          502       |   609          593          622          539       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.134      P=0.100N     P=0.488      P=0.383    |  P=0.444      P=0.451N     P=0.145      P=0.530    |
|INCIDENTAL TUMOR       |  P=0.250N     P=0.406      P=0.193      P=0.414N   |  P=0.523N     P=0.549N     P=0.150      P=0.560N   |
|LOGISTIC REGRESSION    |  P=0.340N     P=0.423      P=0.204      P=0.494N   |  P=0.474N     P=0.488N     P=0.137      P=0.506N   |
|COCHRAN-ARMITAGE       |  P=0.376N                                          |  P=0.374N                                          |
|FISHER EXACT           |               P=0.500      P=0.207      P=0.500N   |               P=0.582N     P=0.156      P=0.445N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%         0.0%         0.0%      |   5.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  0/34 (0%)    0/37 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   541          ---          ---          ---       |   620          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.484N     P=0.483N     P=0.500N     P=0.505N   |  P=0.259N     P=0.222N     P=0.240N     P=0.257N   |
|INCIDENTAL TUMOR       |  P=0.426N     P=0.695N     P=0.557N     P=0.500N   |  P=0.251N     P=0.302N     P=0.249N     P=0.249N   |
|LOGISTIC REGRESSION    |  P=0.388N     P=0.645N     P=0.524N     P=0.446N   |  P=0.234N     P=0.269N     P=0.229N     P=0.233N   |
|COCHRAN-ARMITAGE       |  P=0.474N                                          |  P=0.245N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.247N     P=0.247N     P=0.253N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   6
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)  12/50 (24%)  13/50 (26%)  18/50 (36%) |  3/50 (6%)    6/50 (12%)   9/50 (18%)  10/50 (20%) |
|ADJUSTED (b)           |  30.4%        30.9%        41.1%        54.6%      |   8.8%        15.0%        25.2%        32.8%      |
|TERMINAL (d)           |  4/22 (18%)   6/31 (19%)   7/24 (29%)   7/20 (35%) |  3/34 (9%)    4/37 (11%)   6/32 (19%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |   600          460          548          524       |   734 (T)      664          649          706       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005 **   P=0.589      P=0.308      P=0.024 *  |  P=0.014 *    P=0.297      P=0.056      P=0.016 *  |
|INCIDENTAL TUMOR       |  P=0.018 *    P=0.332      P=0.271      P=0.026 *  |  P=0.026 *    P=0.336      P=0.080      P=0.025 *  |
|LOGISTIC REGRESSION    |  P=0.018 *    P=0.353      P=0.256      P=0.027 *  |  P=0.024 *    P=0.287      P=0.057      P=0.024 *  |
|COCHRAN-ARMITAGE       |  P=0.029 *                                         |  P=0.045 *                                         |
|FISHER EXACT           |               P=0.312      P=0.235      P=0.035 *  |               P=0.243      P=0.061      P=0.036 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    5/50 (10%)   7/50 (14%)  11/50 (22%) |  1/50 (2%)    1/50 (2%)    4/50 (8%)    9/50 (18%) |
|ADJUSTED (b)           |  13.2%        16.1%        25.3%        43.7%      |   2.9%         2.7%         9.2%        25.3%      |
|TERMINAL (d)           |  2/22 (9%)    5/31 (16%)   4/24 (17%)   7/20 (35%) |  1/34 (3%)    1/37 (3%)    1/32 (3%)    4/28 (14%) |
|FIRST INCIDENCE (DAYS) |   449          733 (T)      687          552       |   734 (T)      734 (T)      495          536       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.004 **   P=0.603N     P=0.313      P=0.031 *  |  P<0.001 **   P=0.743N     P=0.173      P=0.007 ** |
|INCIDENTAL TUMOR       |  P=0.008 **   P=0.572      P=0.282      P=0.043 *  |  P=0.001 **   P=0.743N     P=0.142      P=0.016 *  |
|LOGISTIC REGRESSION    |  P=0.006 **   P=0.528      P=0.273      P=0.033 *  |  P<0.001 **   P=0.743N     P=0.201      P=0.009 ** |
|COCHRAN-ARMITAGE       |  P=0.021 *                                         |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.500      P=0.262      P=0.045 *  |               P=0.753N     P=0.181      P=0.008 ** |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   7
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/50 (22%)  14/50 (28%)  19/50 (38%)  28/50 (56%) |  4/50 (8%)    7/50 (14%)  13/50 (26%)  18/50 (36%) |
|ADJUSTED (b)           |  35.5%        36.5%        56.5%        78.8%      |  11.8%        17.5%        32.6%        50.2%      |
|TERMINAL (d)           |  5/22 (23%)   8/31 (26%)  10/24 (42%)  13/20 (65%) |  4/34 (12%)   5/37 (14%)   7/32 (22%)  11/28 (39%) |
|FIRST INCIDENCE (DAYS) |   449          460          548          524       |   734 (T)      664          495          536       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.544N     P=0.122      P<0.001 ** |  P<0.001 **   P=0.322      P=0.016 *    P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.347      P=0.081      P<0.001 ** |  P<0.001 **   P=0.360      P=0.020 *    P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.345      P=0.071      P<0.001 ** |  P<0.001 **   P=0.318      P=0.016 *    P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.322      P=0.063      P<0.001 ** |               P=0.262      P=0.016 *    P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         2.7%         3.1%         6.3%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  0/34 (0%)    1/37 (3%)    1/32 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   643          734 (T)      734 (T)      692       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.298      P=0.736N     P=0.756      P=0.466    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.316      P=0.635      P=0.678      P=0.468    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.343      P=0.753      P=0.763N     P=0.498    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.360                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.753N     P=0.753N     P=0.500    |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   8
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         2.7%         3.1%         6.3%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  0/34 (0%)    1/37 (3%)    1/32 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   643          734 (T)      734 (T)      692       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.298      P=0.736N     P=0.756      P=0.466    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.316      P=0.635      P=0.678      P=0.468    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.343      P=0.753      P=0.763N     P=0.498    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.360                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.753N     P=0.753N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/48 (4%)    3/49 (6%)    3/49 (6%)    3/48 (6%)  |
|ADJUSTED (b)           |                                                    |   6.3%         8.3%         9.4%        10.7%      |
|TERMINAL (d)           |                                                    |  2/32 (6%)    3/36 (8%)    3/32 (9%)    3/28 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   734 (T)      734 (T)      734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.390      P=0.554      P=0.500      P=0.439    |
|INCIDENTAL TUMOR       |                                                    |  P=0.390      P=0.554      P=0.500      P=0.439    |
|LOGISTIC REGRESSION    |                                                    |  P=0.390      P=0.554      P=0.500      P=0.439    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.487                                           |
|FISHER EXACT           |                                                    |               P=0.510      P=0.510      P=0.500    |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE   9
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/48 (0%)    0/50 (0%)    0/48 (0%)    0/47 (0%)  | 11/48 (23%)   8/47 (17%)   7/47 (15%)   8/48 (17%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  30.0%        22.2%        20.7%        24.7%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/23 (0%)    0/20 (0%)  |  8/33 (24%)   8/36 (22%)   5/30 (17%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   596          734 (T)      659          675       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.538N     P=0.236N     P=0.271N     P=0.426N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.440N     P=0.265N     P=0.222N     P=0.309N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.430N     P=0.255N     P=0.248N     P=0.343N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.355N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.323N     P=0.231N     P=0.305N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.0%         3.2%         0.0%         7.3%      |   0.0%         0.0%         3.1%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    1/31 (3%)    0/24 (0%)    1/20 (5%)  |  0/34 (0%)    0/37 (0%)    1/32 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          733 (T)      ---          555       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.262      P=0.697N     P=0.488N     P=0.459    |  P=0.807        (e)        P=0.488        (e)      |
|INCIDENTAL TUMOR       |  P=0.333      P=0.733N     P=0.484N     P=0.498    |  P=0.807        (e)        P=0.488        (e)      |
|LOGISTIC REGRESSION    |  P=0.330      P=0.750N     P=0.503N     P=0.505    |  P=0.807        (e)        P=0.488        (e)      |
|COCHRAN-ARMITAGE       |  P=0.333                                           |  P=0.786N                                          |
|FISHER EXACT           |               P=0.753N     P=0.500N     P=0.500    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  10
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  6/50 (12%)   2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.4%         0.0%         0.0%         0.0%      |  16.0%         4.3%         0.0%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  4/34 (12%)   0/37 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   575          ---          ---          ---       |   225          593          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.513N     P=0.473N     P=0.505N     P=0.537N   |  P=0.022N*    P=0.116N     P=0.022N*    P=0.029N*  |
|INCIDENTAL TUMOR       |  P=0.344N     P=0.594N     P=0.527N     P=0.375N   |  P=0.015N*    P=0.203N     P=0.016N*    P=0.020N*  |
|LOGISTIC REGRESSION    |  P=0.412N     P=0.611N     P=0.518N     P=0.464N   |  P=0.012N*    P=0.210N     P=0.014N*    P=0.014N*  |
|COCHRAN-ARMITAGE       |  P=0.474N                                          |  P=0.015N*                                         |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.134N     P=0.013N*    P=0.013N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/47 (2%)    3/50 (6%)    1/49 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   3.0%         8.5%         3.1%        10.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    1/31 (3%)    0/24 (0%)    2/20 (10%) |  0/34 (0%)    0/37 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          685          681          733 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.454      P=0.419      P=0.739N     P=0.450    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.431      P=0.333      P=0.746N     P=0.426    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.524      P=0.337      P=0.754N     P=0.465    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.596                                           |    (e)                                             |
|FISHER EXACT           |               P=0.332      P=0.742N     P=0.523    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  11
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         5.7%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    1/31 (3%)    0/24 (0%)    0/20 (0%)  |  0/34 (0%)    0/37 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          666          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.426N     P=0.308        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.439N     P=0.267        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.399N     P=0.260        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.369N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.247        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         5.7%         4.2%         0.0%      |   2.9%         2.7%         0.0%         3.6%      |
|TERMINAL (d)           |  0/22 (0%)    1/31 (3%)    1/24 (4%)    0/20 (0%)  |  1/34 (3%)    1/37 (3%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          666          733 (T)      ---       |   734 (T)      734 (T)      ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.447N     P=0.308      P=0.517        (e)      |  P=0.625      P=0.743N     P=0.512N     P=0.718    |
|INCIDENTAL TUMOR       |  P=0.459N     P=0.267      P=0.517        (e)      |  P=0.625      P=0.743N     P=0.512N     P=0.718    |
|LOGISTIC REGRESSION    |  P=0.431N     P=0.260      P=0.517        (e)      |  P=0.625      P=0.743N     P=0.512N     P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.378N                                          |  P=0.677                                           |
|FISHER EXACT           |               P=0.247      P=0.500        (e)      |               P=0.753N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  12
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  3/50 (6%)    0/49 (0%)    0/49 (0%)    5/49 (10%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         5.0%      |   8.0%         0.0%         0.0%        16.7%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    1/20 (5%)  |  2/34 (6%)    0/36 (0%)    0/32 (0%)    4/28 (14%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          733 (T)   |   619          ---          ---          686       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.172        (e)          (e)        P=0.481    |  P=0.026 *    P=0.113N     P=0.130N     P=0.274    |
|INCIDENTAL TUMOR       |  P=0.172        (e)          (e)        P=0.481    |  P=0.026 *    P=0.184N     P=0.171N     P=0.258    |
|LOGISTIC REGRESSION    |  P=0.172        (e)          (e)        P=0.481    |  P=0.038 *    P=0.126N     P=0.125N     P=0.323    |
|COCHRAN-ARMITAGE       |  P=0.215                                           |  P=0.046 *                                         |
|FISHER EXACT           |                 (e)          (e)        P=0.505    |               P=0.125N     P=0.125N     P=0.346    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  1/50 (2%)    0/49 (0%)    2/49 (4%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.2%         0.0%      |   2.9%         0.0%         6.3%         0.0%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    1/24 (4%)    0/20 (0%)  |  0/34 (0%)    0/36 (0%)    2/32 (6%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      ---       |   713          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.809        (e)        P=0.517        (e)      |  P=0.509N     P=0.473N     P=0.483      P=0.518N   |
|INCIDENTAL TUMOR       |  P=0.809        (e)        P=0.517        (e)      |  P=0.460N     P=0.398N     P=0.532      P=0.379N   |
|LOGISTIC REGRESSION    |  P=0.809        (e)        P=0.517        (e)      |  P=0.483N     P=0.496N     P=0.490      P=0.512N   |
|COCHRAN-ARMITAGE       |  P=0.785N                                          |  P=0.459N                                          |
|FISHER EXACT           |                 (e)        P=0.505        (e)      |               P=0.505N     P=0.492      P=0.505N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  13
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  4/50 (8%)    0/49 (0%)    2/49 (4%)    5/49 (10%) |
|ADJUSTED (b)           |   0.0%         0.0%         4.2%         5.0%      |  10.6%         0.0%         6.3%        16.7%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    1/24 (4%)    1/20 (5%)  |  2/34 (6%)    0/36 (0%)    2/32 (6%)    4/28 (14%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      733 (T)   |   619          ---          734 (T)      686       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.243        (e)        P=0.517      P=0.481    |  P=0.081      P=0.056N     P=0.360N     P=0.407    |
|INCIDENTAL TUMOR       |  P=0.243        (e)        P=0.517      P=0.481    |  P=0.092      P=0.075N     P=0.377N     P=0.437    |
|LOGISTIC REGRESSION    |  P=0.243        (e)        P=0.517      P=0.481    |  P=0.108      P=0.065N     P=0.351N     P=0.462    |
|COCHRAN-ARMITAGE       |  P=0.305                                           |  P=0.130                                           |
|FISHER EXACT           |                 (e)        P=0.505      P=0.505    |               P=0.061N     P=0.349N     P=0.487    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         2.7%         5.9%         0.0%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    1/37 (3%)    1/32 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          734 (T)      709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.569N     P=0.517      P=0.233        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.523N     P=0.517      P=0.287        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.545N     P=0.517      P=0.235        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.515N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.247        (e)      |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  14
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         5.3%         0.0%         0.0%      |
|TERMINAL (d)           |                                                    |  0/34 (0%)    1/37 (3%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          727          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.412N     P=0.262        (e)          (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.354N     P=0.305        (e)          (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.393N     P=0.262        (e)          (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.369N                                          |
|FISHER EXACT           |                                                    |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   9.1%         0.0%         0.0%         0.0%      |   0.0%         2.7%         5.9%         3.6%      |
|TERMINAL (d)           |  2/22 (9%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  0/34 (0%)    1/37 (3%)    1/32 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          ---       |   ---          734 (T)      709          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.275N     P=0.166N     P=0.218N     P=0.258N   |  P=0.435      P=0.517      P=0.233      P=0.461    |
|INCIDENTAL TUMOR       |  P=0.275N     P=0.166N     P=0.218N     P=0.258N   |  P=0.474      P=0.517      P=0.287      P=0.461    |
|LOGISTIC REGRESSION    |  P=0.275N     P=0.166N     P=0.218N     P=0.258N   |  P=0.464      P=0.517      P=0.235      P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.242N                                          |  P=0.500                                           |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |               P=0.500      P=0.247      P=0.500    |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  15
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   8/50 (16%)   9/50 (18%) |  1/50 (2%)    2/50 (4%)    4/50 (8%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.8%        17.6%        23.5%        31.1%      |   2.9%         4.8%        10.3%         0.0%      |
|TERMINAL (d)           |  2/22 (9%)    4/31 (13%)   2/24 (8%)    4/20 (20%) |  1/34 (3%)    1/37 (3%)    2/32 (6%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          685          523          502       |   734 (T)      652          524          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.025 *    P=0.423      P=0.139      P=0.047 *  |  P=0.321N     P=0.536      P=0.173      P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.070      P=0.347      P=0.107      P=0.065    |  P=0.215N     P=0.578      P=0.183      P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.061      P=0.344      P=0.103      P=0.054    |  P=0.250N     P=0.505      P=0.184      P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.079                                           |  P=0.263N                                          |
|FISHER EXACT           |               P=0.243      P=0.100      P=0.061    |               P=0.500      P=0.181      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   6/50 (12%)   8/50 (16%)   9/50 (18%) |  1/50 (2%)    3/50 (6%)    6/50 (12%)   1/50 (2%)  |
|ADJUSTED (b)           |  20.7%        17.6%        23.5%        31.1%      |   2.9%         7.5%        15.8%         3.6%      |
|TERMINAL (d)           |  4/22 (18%)   4/31 (13%)   2/24 (8%)    4/20 (20%) |  1/34 (3%)    2/37 (5%)    3/32 (9%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   651          685          523          502       |   734 (T)      652          524          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.060      P=0.528N     P=0.338      P=0.149    |  P=0.499N     P=0.342      P=0.057      P=0.718    |
|INCIDENTAL TUMOR       |  P=0.137      P=0.599N     P=0.293      P=0.192    |  P=0.370N     P=0.375      P=0.071      P=0.718    |
|LOGISTIC REGRESSION    |  P=0.120      P=0.605N     P=0.289      P=0.162    |  P=0.406N     P=0.319      P=0.059      P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.160                                           |  P=0.403N                                          |
|FISHER EXACT           |               P=0.500      P=0.277      P=0.194    |               P=0.309      P=0.056      P=0.753N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  16
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  3/50 (6%)    2/50 (4%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   4.2%         0.0%         0.0%         4.5%      |   7.7%         4.8%         0.0%         7.9%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  0/34 (0%)    1/37 (3%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   711          ---          ---          686       |   656          649          ---          639       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.469      P=0.436N     P=0.500N     P=0.722    |  P=0.456      P=0.452N     P=0.126N     P=0.644    |
|INCIDENTAL TUMOR       |  P=0.426      P=0.517N     P=0.484N     P=0.640    |  P=0.594      P=0.301N     P=0.039N*    P=0.474N   |
|LOGISTIC REGRESSION    |  P=0.502      P=0.463N     P=0.489N     P=0.738    |  P=0.496      P=0.396N     P=0.118N     P=0.644N   |
|COCHRAN-ARMITAGE       |  P=0.536                                           |  P=0.500                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.753N   |               P=0.500N     P=0.121N     P=0.661N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |  4/50 (8%)    7/50 (14%)   7/50 (14%)   5/50 (10%) |
|ADJUSTED (b)           |   3.3%         3.1%         2.9%         0.0%      |  10.8%        16.8%        19.8%        13.4%      |
|TERMINAL (d)           |  0/22 (0%)    0/31 (0%)    0/24 (0%)    0/20 (0%)  |  3/34 (9%)    3/37 (8%)    5/32 (16%)   1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   676          726          652          ---       |   583          666          649          356       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.393N     P=0.694N     P=0.743N     P=0.553N   |  P=0.492      P=0.327      P=0.240      P=0.429    |
|INCIDENTAL TUMOR       |  P=0.430N     P=0.746      P=0.747N     P=0.607N   |  P=0.526N     P=0.329      P=0.253      P=0.435    |
|LOGISTIC REGRESSION    |  P=0.339N     P=0.738N     P=0.762      P=0.512N   |  P=0.524N     P=0.267      P=0.255      P=0.527    |
|COCHRAN-ARMITAGE       |  P=0.323N                                          |  P=0.528N                                          |
|FISHER EXACT           |               P=0.753N     P=0.753N     P=0.500N   |               P=0.262      P=0.262      P=0.500    |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  17
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/50 (60%)  30/50 (60%)  30/50 (60%)  27/50 (54%) | 25/50 (50%)  32/50 (64%)  27/50 (54%)  27/50 (54%) |
|ADJUSTED (b)           |  84.8%        74.3%        77.7%        73.0%      |  65.5%        76.0%        68.9%        72.1%      |
|TERMINAL (d)           | 17/22 (77%)  21/31 (68%)  16/24 (67%)  11/20 (55%) | 21/34 (62%)  27/37 (73%)  20/32 (63%)  18/28 (64%) |
|FIRST INCIDENCE (DAYS) |   470          460          440          524       |   596          593          622          539       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.276      P=0.086N     P=0.430N     P=0.538    |  P=0.185      P=0.242      P=0.336      P=0.163    |
|INCIDENTAL TUMOR       |  P=0.359N     P=0.338N     P=0.530N     P=0.430N   |  P=0.332      P=0.176      P=0.395      P=0.257    |
|LOGISTIC REGRESSION    |  P=0.437N     P=0.353N     P=0.542N     P=0.444N   |  P=0.408      P=0.220      P=0.390      P=0.305    |
|COCHRAN-ARMITAGE       |  P=0.279N                                          |  P=0.465N                                          |
|FISHER EXACT           |               P=0.581N     P=0.581N     P=0.343N   |               P=0.113      P=0.421      P=0.421    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/50 (66%)  39/50 (78%)  41/50 (82%)  38/50 (76%) | 27/50 (54%)  22/50 (44%)  31/50 (62%)  21/50 (42%) |
|ADJUSTED (b)           |  73.8%        79.4%        85.1%        87.8%      |  58.5%        47.6%        68.3%        49.5%      |
|TERMINAL (d)           | 11/22 (50%)  21/31 (68%)  17/24 (71%)  15/20 (75%) | 15/34 (44%)  13/37 (35%)  18/32 (56%)   7/28 (25%) |
|FIRST INCIDENCE (DAYS) |   449          460          440          502       |   225          593          495          356       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.053      P=0.374N     P=0.270      P=0.141    |  P=0.530N     P=0.154N     P=0.268      P=0.368N   |
|INCIDENTAL TUMOR       |  P=0.431      P=0.045 *    P=0.040 *    P=0.224    |  P=0.161N     P=0.241N     P=0.245      P=0.111N   |
|LOGISTIC REGRESSION    |  P=0.412      P=0.042 *    P=0.037 *    P=0.205    |  P=0.187N     P=0.266N     P=0.276      P=0.147N   |
|COCHRAN-ARMITAGE       |  P=0.318                                           |  P=0.199N                                          |
|FISHER EXACT           |               P=0.133      P=0.055      P=0.189    |               P=0.212N     P=0.272      P=0.158N   |
|=================================================================================================================================|
         DATE: 07/03/96                     EXPERIMENT: 05156 TEST: 06                                                 PAGE  18
                       STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 49/50 (98%)  48/50 (96%)  47/50 (94%)  46/50 (92%) | 42/50 (84%)  41/50 (82%)  43/50 (86%)  39/50 (78%) |
|ADJUSTED (b)           | 100.0%        96.0%        95.9%        95.8%      |  89.3%        87.2%        91.4%        84.8%      |
|TERMINAL (d)           | 22/22 (100%) 29/31 (94%)  22/24 (92%)  18/20 (90%) | 29/34 (85%)  31/37 (84%)  28/32 (88%)  21/28 (75%) |
|FIRST INCIDENCE (DAYS) |   449          460          440          502       |   225          593          495          356       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.114      P=0.028N*    P=0.283N     P=0.435    |  P=0.213      P=0.255N     P=0.387      P=0.395    |
|INCIDENTAL TUMOR       |  P=0.160N     P=0.526N     P=0.286N     P=0.205N   |  P=0.507N     P=0.473N     P=0.400      P=0.542N   |
|LOGISTIC REGRESSION    |  P=0.238N     P=0.527N     P=0.297N     P=0.279N   |  P=0.366N     P=0.422N     P=0.459      P=0.353N   |
|COCHRAN-ARMITAGE       |  P=0.143N                                          |  P=0.258N                                          |
|FISHER EXACT           |               P=0.500N     P=0.309N     P=0.181N   |               P=0.500N     P=0.500      P=0.306N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.