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TDMS Study 05156-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/03/96       
EXPERIMENT: 05156 TEST: 06                                                                                     TIME: 11:52:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: MELLICK, P.                                                                                       CAS: 10026-24-1      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/03/96      
EXPERIMENT: 05156 TEST: 06                                                                                     TIME: 11:52:30      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B      
PATHOLOGIST: MELLICK, P.                                                                                       CAS: 10026-24-1     
                            COBALT SULFATE HEPTAHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 1    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      449   470   482   486   516   533   541   541   555   575                 |
 |      579   600   600   611   640   643   649   651   652   652                 |
 |      676   685   686   686   708   711   725                                   |
 |  CENSORED DEATHS                                                               |
 |      680                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.3     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      460   501   541   583   599   611   614   617   649   652                 |
 |      653   666   666   685   687   690   709   720   726                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      440   483   505   510   523   534   548   555   560   561                 |
 |      597   610   639   645   645   652   653   670   681   681                 |
 |      687   699   705   706   708   709                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                            COBALT SULFATE HEPTAHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 3.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 29     CENSORED DEATHS 1    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   414   502   524   527   533   536   541   552   555                 |
 |      555   555   560   561   561   566   608   611   613   618                 |
 |      618   622   639   649   652   653   673   686   713                       |
 |  CENSORED DEATHS                                                               |
 |      678                                                                       |
 |                                                                                |
 ==================================================================================
                            COBALT SULFATE HEPTAHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  94.0  84.0  74.0  60.0  45.6      |
 |           |                                                                    |
 |           |                                                                    |
 |0.3        |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  90.0  78.0  62.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |1.0        |   100.0 100.0 100.0 100.0 100.0  96.0  88.0  78.0  66.0  48.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |3.0        |   100.0 100.0 100.0 100.0  96.0  96.0  84.0  68.0  48.0  41.8      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      0.3          1.0          3.0      |
 |                                             MG/M3        MG/M3        MG/M3    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       45.6%        62.0%        48.0%        41.8%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.104      P=0.088N     P=0.861N     P=0.577  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       603.8        633.1        611.8        579.2    |
 |NATURAL DEATHS (C)      |       (15.5)       (16.6)       (15.9)       (13.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       662.2        695.0        670.0        642.7    |
 |(STANDARD ERROR)        |       (12.3)       ( 9.3)       (11.9)       (13.2)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                            COBALT SULFATE HEPTAHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      225   531   559   583   596   609   619   620   639   643                 |
 |      652   656   677   699   699   713                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0.3     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      481   593   596   649   652   664   666   666   666   693                 |
 |      720   726   727                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      9     495   505   524   548   569   622   640   649   659                 |
 |      666   666   667   674   703   709   720   733                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                            COBALT SULFATE HEPTAHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 3.0     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      356   429   443   462   484   536   539   606   609   611                 |
 |      639   667   675   680   686   692   706   712   717   719                 |
 |      726   732                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                            COBALT SULFATE HEPTAHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  98.0  98.0  96.0  90.0  76.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.3        |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  94.0  88.0  74.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |1.0        |    98.0  98.0  98.0  98.0  98.0  98.0  92.0  88.0  80.0  64.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 |3.0        |   100.0 100.0 100.0  98.0  98.0  90.0  86.0  86.0  78.0  56.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      0.3          1.0          3.0      |
 |                                             MG/M3        MG/M3        MG/M3    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%        74.0%        64.0%        56.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.102      P=0.529N     P=0.855      P=0.327  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       607.5        653.8        597.7        610.3    |
 |NATURAL DEATHS (C)      |       (28.5)       (18.6)       (38.8)       (24.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       693.5        713.1        684.9        679.6    |
 |(STANDARD ERROR)        |       (12.3)       ( 6.9)       (16.6)       (13.7)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                    COBALT SULFATE HEPTAHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.3     MG/M3    = 2
                                                        1.0     MG/M3    = 3
                                                        3.0     MG/M3    = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                              4     3  12
      |                                                                4  4  3  12 13  2
      |                                                                   4        111 23  4  2     2
      |                                                                              1  31 34       2  2
P  90 +                                                                                  1 341         2 2
E     |                                                                                      113
R     |                                                                                      4131        22   2
C     |                                                                                        413 1          22
E  80 +                                                                                          3     3
N     |                                                                                            1   1 3     2  2
T     |                                                                                         44     1 1   33   2 2
      |                                                                                                  1   1      22
S  70 +                                                                                                       33
U     |                                                                                          4      4    11      2  2
R     |                                                                                                 44    11  3 3   222
V     |                                                                                                  44               2 2
I  60 +                                                                                                        1   133
V     |                                                                                                            1133
A     |                                                                                                   4  44       33
L     |                                                                                                       44    1  31
   50 +
      |                                                                                                        4   4    1 1 3
      |                                                                                                            44   4 1 1
      |                                                                                                                 4   4
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 29 obs hidden.
                                                    COBALT SULFATE HEPTAHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.3     MG/M3    = 2
                                                        1.0     MG/M3    = 3
                                                        3.0     MG/M3    = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 3                                 1                   4                   2
      |
      |   3                                 1                   4           4       2 3     1         2
      |                                                                     4 4       3 3   1   1     22
   95 +
      |                                                                       4  4      3  3    1   1  2      2
      |                                                                          4   4     3   3    1  1      22
      |
   90 +                                                                              4       4 3  3    11      2 2
      |
P     |                                                                                           3     1 1      22
E     |                                                                                      4          4 3  3
R  85 +
C     |                                                                                                   1  13
E     |                                                                                                 44    3  32  2
N     |
T  80 +                                                                                                  4   1 1 33  2   2
      |
S     |                                                                                                      4    4      22
U     |                                                                                                        1  41
R  75 +
V     |                                                                                                           314 1   2 2
I     |                                                                                                            3   3
V     |
A  70 +                                                                                                             44131
L     |
      |                                                                                                              4 413  1
      |                                                                                                                443  3
   65 +
      |                                                                                                                 44  3
      |
      |
   60 +                                                                                                                  44
      |
      |                                                                                                                   4 4
      |                                                                                                                     4
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.