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TDMS Study 05156-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/25/96       
EXPERIMENT: 05156 TEST: 05                                                                                     TIME: 10:48:06       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 10026-24-1      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/25/96       
EXPERIMENT: 05156 TEST: 05                                                                                     TIME: 10:48:06       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 10026-24-1      


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                COBALT SULFATE HEPTAHYDRATE                             DATE: 07/25/96       
EXPERIMENT: 05156 TEST: 05                                                                                     TIME: 10:48:06       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05287                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61530B       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 10026-24-1      


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                 IN THE ANALYSIS OF THE STUDY OF 1  COBALT SULFATE HEPTAHYDRATE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
                                            Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Islets, Pancreatic            Adenoma
                                            Carcinoma or Adenoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              ====================================================================================================
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   1
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/50 (28%)  19/50 (38%)  23/49 (47%)  20/50 (40%) |  2/48 (4%)    1/49 (2%)    3/50 (6%)    8/48 (17%) |
|ADJUSTED (b)           |  51.0%        70.0%        71.9%        71.4%      |   5.1%         3.1%         9.3%        26.4%      |
|TERMINAL (d)           |  6/17 (35%)   8/15 (53%)  13/21 (62%)   8/15 (53%) |  0/27 (0%)    0/25 (0%)    1/26 (4%)    7/29 (24%) |
|FIRST INCIDENCE (DAYS) |   534          541          526          526       |   666          702          694          709       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.166      P=0.220      P=0.214      P=0.134    |  P=0.006 **   P=0.546N     P=0.483      P=0.054    |
|INCIDENTAL TUMOR       |  P=0.190      P=0.199      P=0.040 *    P=0.141    |  P=0.005 **   P=0.471N     P=0.554      P=0.056    |
|LOGISTIC REGRESSION    |  P=0.172      P=0.226      P=0.069      P=0.126    |  P=0.004 **   P=0.498N     P=0.512      P=0.043 *  |
|COCHRAN-ARMITAGE       |  P=0.229                                           |  P=0.003 **                                        |
|FISHER EXACT           |               P=0.198      P=0.041 *    P=0.146    |               P=0.492N     P=0.520      P=0.045 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    2/49 (4%)    2/50 (4%)  |  0/48 (0%)    0/49 (0%)    1/50 (2%)    1/48 (2%)  |
|ADJUSTED (b)           |   0.0%        12.5%         7.9%         9.6%      |   0.0%         0.0%         2.6%         2.5%      |
|TERMINAL (d)           |  0/17 (0%)    1/15 (7%)    1/21 (5%)    0/15 (0%)  |  0/27 (0%)    0/25 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          722          673          663       |   ---          ---          685          663       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.310      P=0.213      P=0.293      P=0.238    |  P=0.303        (e)        P=0.495      P=0.495    |
|INCIDENTAL TUMOR       |  P=0.301      P=0.286      P=0.313      P=0.280    |  P=0.289        (e)        P=0.531      P=0.500    |
|LOGISTIC REGRESSION    |  P=0.315      P=0.225      P=0.271      P=0.232    |  P=0.302        (e)        P=0.511      P=0.510    |
|COCHRAN-ARMITAGE       |  P=0.342                                           |  P=0.299                                           |
|FISHER EXACT           |               P=0.247      P=0.242      P=0.247    |                 (e)        P=0.510      P=0.500    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   2
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/50 (30%)  19/50 (38%)  25/49 (51%)  20/50 (40%) |  2/48 (4%)    1/49 (2%)    4/50 (8%)   10/48 (21%) |
|ADJUSTED (b)           |  52.1%        70.0%        74.1%        71.4%      |   5.1%         3.1%        11.7%        31.5%      |
|TERMINAL (d)           |  6/17 (35%)   8/15 (53%)  13/21 (62%)   8/15 (53%) |  0/27 (0%)    0/25 (0%)    1/26 (4%)    8/29 (28%) |
|FIRST INCIDENCE (DAYS) |   534          541          526          526       |   666          702          685          663       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.206      P=0.285      P=0.188      P=0.182    |  P=0.001 **   P=0.546N     P=0.325      P=0.019 *  |
|INCIDENTAL TUMOR       |  P=0.236      P=0.257      P=0.027 *    P=0.194    |  P<0.001 **   P=0.471N     P=0.390      P=0.019 *  |
|LOGISTIC REGRESSION    |  P=0.218      P=0.295      P=0.045 *    P=0.180    |  P<0.001 **   P=0.498N     P=0.323      P=0.014 *  |
|COCHRAN-ARMITAGE       |  P=0.279                                           |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.263      P=0.027 *    P=0.201    |               P=0.492N     P=0.359      P=0.014 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        11.4%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          631          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.258N     P=0.146        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.261N     P=0.173        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.257N     P=0.123        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.255N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.121        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   3
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)  |  5/50 (10%)   7/48 (15%)   5/48 (10%)   3/49 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.8%         3.4%      |  16.0%        23.4%        17.8%         8.8%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  2/28 (7%)    4/24 (17%)   3/26 (12%)   1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          654          638       |   727          652          727          680       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.337        (e)        P=0.318      P=0.514    |  P=0.160N     P=0.289      P=0.567      P=0.360N   |
|INCIDENTAL TUMOR       |  P=0.341        (e)        P=0.338      P=0.489    |  P=0.189N     P=0.323      P=0.608      P=0.398N   |
|LOGISTIC REGRESSION    |  P=0.347        (e)        P=0.242      P=0.501    |  P=0.182N     P=0.286      P=0.581      P=0.384N   |
|COCHRAN-ARMITAGE       |  P=0.350                                           |  P=0.189N                                          |
|FISHER EXACT           |                 (e)        P=0.242      P=0.500    |               P=0.351      P=0.603      P=0.369N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    0/49 (0%)    3/50 (6%)  |  2/50 (4%)    3/48 (6%)    4/48 (8%)    3/49 (6%)  |
|ADJUSTED (b)           |  14.7%        11.1%         0.0%        12.8%      |   7.1%         9.3%        13.4%        10.0%      |
|TERMINAL (d)           |  1/17 (6%)    0/15 (0%)    0/21 (0%)    1/15 (7%)  |  2/28 (7%)    1/24 (4%)    2/26 (8%)    3/30 (10%) |
|FIRST INCIDENCE (DAYS) |   679          701          ---          511       |   735 (T)      610          694          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.472      P=0.512N     P=0.087N     P=0.632    |  P=0.548      P=0.439      P=0.305      P=0.532    |
|INCIDENTAL TUMOR       |  P=0.481      P=0.303N     P=0.065N     P=0.624N   |  P=0.518      P=0.398      P=0.315      P=0.532    |
|LOGISTIC REGRESSION    |  P=0.486      P=0.229N     P=0.093N     P=0.657    |  P=0.504      P=0.459      P=0.301      P=0.532    |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.499                                           |
|FISHER EXACT           |               P=0.500N     P=0.125N     P=0.661N   |               P=0.480      P=0.319      P=0.490    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   4
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/49 (4%)    4/50 (8%)  |  7/50 (14%)  10/48 (21%)   8/48 (17%)   6/49 (12%) |
|ADJUSTED (b)           |  14.7%        11.1%         6.8%        15.8%      |  22.5%        31.1%        27.0%        18.2%      |
|TERMINAL (d)           |  1/17 (6%)    0/15 (0%)    0/21 (0%)    1/15 (7%)  |  4/28 (14%)   5/24 (21%)   5/26 (19%)   4/30 (13%) |
|FIRST INCIDENCE (DAYS) |   679          701          654          511       |   727          610          694          680       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.292      P=0.512N     P=0.380N     P=0.478    |  P=0.234N     P=0.207      P=0.429      P=0.480N   |
|INCIDENTAL TUMOR       |  P=0.293      P=0.303N     P=0.319N     P=0.535    |  P=0.279N     P=0.207      P=0.462      P=0.517N   |
|LOGISTIC REGRESSION    |  P=0.305      P=0.229N     P=0.329N     P=0.494    |  P=0.280N     P=0.205      P=0.432      P=0.545N   |
|COCHRAN-ARMITAGE       |  P=0.320                                           |  P=0.291N                                          |
|FISHER EXACT           |               P=0.500N     P=0.510N     P=0.500    |               P=0.266      P=0.465      P=0.516N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Schwannoma Benign                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/49 (4%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   3.1%         6.1%         7.7%         3.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    1/25 (4%)    2/26 (8%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   727          517          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.489N     P=0.458      P=0.471      P=0.760N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.519N     P=0.662      P=0.491      P=0.759    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.519N     P=0.527      P=0.478      P=0.752    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.518N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.492      P=0.500      P=0.753N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   5
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   5/48 (10%)   5/50 (10%) |  4/49 (8%)    1/49 (2%)    0/50 (0%)    0/48 (0%)  |
|ADJUSTED (b)           |  10.2%        21.3%        18.3%        20.5%      |  14.3%         4.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    2/15 (13%)   3/21 (14%)   1/15 (7%)  |  4/28 (14%)   1/25 (4%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   679          471          509          611       |   735 (T)      735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.278      P=0.217      P=0.301      P=0.222    |  P=0.049N*    P=0.212N     P=0.071N     P=0.053N   |
|INCIDENTAL TUMOR       |  P=0.306      P=0.284      P=0.227      P=0.231    |  P=0.049N*    P=0.212N     P=0.071N     P=0.053N   |
|LOGISTIC REGRESSION    |  P=0.304      P=0.224      P=0.226      P=0.208    |  P=0.049N*    P=0.212N     P=0.071N     P=0.053N   |
|COCHRAN-ARMITAGE       |  P=0.316                                           |  P=0.058N                                          |
|FISHER EXACT           |               P=0.218      P=0.201      P=0.218    |               P=0.181N     P=0.056N     P=0.061N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    4/48 (8%)    7/50 (14%) |  2/49 (4%)    0/49 (0%)    1/50 (2%)    0/48 (0%)  |
|ADJUSTED (b)           |  11.4%        19.8%        14.3%        33.2%      |   5.6%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    1/21 (5%)    2/15 (13%) |  1/28 (4%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   526          680          657          638       |   572          ---          727          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.089      P=0.501      P=0.611      P=0.149    |  P=0.264N     P=0.267N     P=0.527N     P=0.234N   |
|INCIDENTAL TUMOR       |  P=0.077      P=0.642      P=0.654      P=0.185    |  P=0.296N     P=0.328N     P=0.524N     P=0.305N   |
|LOGISTIC REGRESSION    |  P=0.091      P=0.515      P=0.489      P=0.149    |  P=0.279N     P=0.209N     P=0.484N     P=0.242N   |
|COCHRAN-ARMITAGE       |  P=0.110                                           |  P=0.275N                                          |
|FISHER EXACT           |               P=0.500      P=0.477      P=0.159    |               P=0.247N     P=0.492N     P=0.253N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   6
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   9/50 (18%)   9/48 (19%)  11/50 (22%) |  6/49 (12%)   1/49 (2%)    1/50 (2%)    0/48 (0%)  |
|ADJUSTED (b)           |  20.7%        37.6%        30.6%        44.7%      |  19.6%         4.0%         3.4%         0.0%      |
|TERMINAL (d)           |  2/17 (12%)   3/15 (20%)   4/21 (19%)   3/15 (20%) |  5/28 (18%)   1/25 (4%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   526          471          509          611       |   572          735 (T)      727          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.101      P=0.202      P=0.328      P=0.088    |  P=0.023N*    P=0.078N     P=0.073N     P=0.015N*  |
|INCIDENTAL TUMOR       |  P=0.100      P=0.322      P=0.288      P=0.099    |  P=0.025N*    P=0.092N     P=0.072N     P=0.020N*  |
|LOGISTIC REGRESSION    |  P=0.107      P=0.205      P=0.192      P=0.077    |  P=0.025N*    P=0.069N     P=0.059N     P=0.019N*  |
|COCHRAN-ARMITAGE       |  P=0.127                                           |  P=0.027N*                                         |
|FISHER EXACT           |               P=0.194      P=0.172      P=0.086    |               P=0.056N     P=0.053N     P=0.014N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    1/48 (2%)    6/50 (12%) |  0/50 (0%)    1/49 (2%)   10/50 (20%)   9/50 (18%) |
|ADJUSTED (b)           |   2.3%        17.7%         2.4%        28.4%      |   0.0%         3.4%        36.4%        30.0%      |
|TERMINAL (d)           |  0/17 (0%)    2/15 (13%)   0/21 (0%)    2/15 (13%) |  0/28 (0%)    0/25 (0%)    9/26 (35%)   9/30 (30%) |
|FIRST INCIDENCE (DAYS) |   568          589          611          638       |   ---          714          692          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.042 *    P=0.187      P=0.726N     P=0.056    |  P=0.003 **   P=0.468      P<0.001 **   P=0.003 ** |
|INCIDENTAL TUMOR       |  P=0.054      P=0.124      P=0.538      P=0.064    |  P=0.003 **   P=0.500      P<0.001 **   P=0.003 ** |
|LOGISTIC REGRESSION    |  P=0.051      P=0.179      P=0.753      P=0.055    |  P=0.001 **   P=0.480      P<0.001 **   P=0.003 ** |
|COCHRAN-ARMITAGE       |  P=0.055                                           |  P=0.002 **                                        |
|FISHER EXACT           |               P=0.181      P=0.742      P=0.056    |               P=0.495      P<0.001 **   P=0.001 ** |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   7
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    3/48 (6%)    1/50 (2%)  |  0/50 (0%)    2/49 (4%)    6/50 (12%)   6/50 (12%) |
|ADJUSTED (b)           |   0.0%         0.0%        11.3%         6.7%      |   0.0%         8.0%        20.2%        17.5%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    1/21 (5%)    1/15 (7%)  |  0/28 (0%)    2/25 (8%)    4/26 (15%)   4/30 (13%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          652          734 (T)   |   ---          735 (T)      694          610       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.355        (e)        P=0.181      P=0.475    |  P=0.033 *    P=0.213      P=0.015 *    P=0.022 *  |
|INCIDENTAL TUMOR       |  P=0.349        (e)        P=0.192      P=0.475    |  P=0.028 *    P=0.213      P=0.017 *    P=0.016 *  |
|LOGISTIC REGRESSION    |  P=0.360        (e)        P=0.136      P=0.475    |  P=0.023 *    P=0.213      P=0.015 *    P=0.017 *  |
|COCHRAN-ARMITAGE       |  P=0.382                                           |  P=0.022 *                                         |
|FISHER EXACT           |                 (e)        P=0.114      P=0.500    |               P=0.242      P=0.013 *    P=0.013 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    4/48 (8%)    7/50 (14%) |  0/50 (0%)    3/49 (6%)   15/50 (30%)  15/50 (30%) |
|ADJUSTED (b)           |   2.3%        17.7%        13.4%        33.9%      |   0.0%        11.2%        50.6%        46.1%      |
|TERMINAL (d)           |  0/17 (0%)    2/15 (13%)   1/21 (5%)    3/15 (20%) |  0/28 (0%)    2/25 (8%)   12/26 (46%)  13/30 (43%) |
|FIRST INCIDENCE (DAYS) |   568          589          611          638       |   ---          714          692          610       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.027 *    P=0.187      P=0.263      P=0.030 *  |  P<0.001 **   P=0.101      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.033 *    P=0.124      P=0.131      P=0.034 *  |  P<0.001 **   P=0.109      P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.032 *    P=0.179      P=0.163      P=0.029 *  |  P<0.001 **   P=0.096      P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.038 *                                         |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.181      P=0.168      P=0.030 *  |               P=0.117      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   8
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.1%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   572          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.242N     P=0.274N     P=0.258N     P=0.249N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.267N     P=0.314N     P=0.262N     P=0.301N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.227N     P=0.209N     P=0.219N     P=0.214N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.241N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.253N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    2/49 (4%)    5/50 (10%)   5/50 (10%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.5%         5.4%        15.9%        15.9%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  1/28 (4%)    0/25 (0%)    2/26 (8%)    4/30 (13%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   638          526          695          693       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.247      P=0.555N     P=0.333      P=0.370    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.205      P=0.438N     P=0.342      P=0.339    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.216      P=0.471N     P=0.341      P=0.342    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.217                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.510N     P=0.357      P=0.357    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE   9
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  5/50 (10%)   2/49 (4%)    5/50 (10%)   5/50 (10%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  13.2%         5.4%        15.9%        15.9%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  1/28 (4%)    0/25 (0%)    2/26 (8%)    4/30 (13%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   572          526          695          693       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.423      P=0.280N     P=0.589      P=0.621N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.365      P=0.205N     P=0.604      P=0.578    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.390      P=0.182N     P=0.626      P=0.622    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.393                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.226N     P=0.630N     P=0.630N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    1/50 (2%)    2/50 (4%)    4/50 (8%)  | 22/50 (44%)  22/49 (45%)  20/50 (40%)  27/50 (54%) |
|ADJUSTED (b)           |  17.6%         6.7%         7.6%        21.2%      |  54.6%        67.3%        56.5%        70.5%      |
|TERMINAL (d)           |  3/17 (18%)   1/15 (7%)    1/21 (5%)    2/15 (13%) | 11/28 (39%)  15/25 (60%)  12/26 (46%)  19/30 (63%) |
|FIRST INCIDENCE (DAYS) |   734 (T)      734 (T)      652          611       |   569          610          510          386       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.199      P=0.346N     P=0.391N     P=0.449    |  P=0.291      P=0.386      P=0.524N     P=0.280    |
|INCIDENTAL TUMOR       |  P=0.203      P=0.346N     P=0.383N     P=0.462    |  P=0.170      P=0.303      P=0.481N     P=0.205    |
|LOGISTIC REGRESSION    |  P=0.203      P=0.346N     P=0.398N     P=0.475    |  P=0.147      P=0.439      P=0.435N     P=0.182    |
|COCHRAN-ARMITAGE       |  P=0.240                                           |  P=0.153                                           |
|FISHER EXACT           |               P=0.309N     P=0.500N     P=0.500    |               P=0.545      P=0.420N     P=0.212    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  10
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    1/50 (2%)    2/50 (4%)    4/50 (8%)  | 23/50 (46%)  22/49 (45%)  20/50 (40%)  27/50 (54%) |
|ADJUSTED (b)           |  17.6%         6.7%         7.6%        21.2%      |  55.6%        67.3%        56.5%        70.5%      |
|TERMINAL (d)           |  3/17 (18%)   1/15 (7%)    1/21 (5%)    2/15 (13%) | 11/28 (39%)  15/25 (60%)  12/26 (46%)  19/30 (63%) |
|FIRST INCIDENCE (DAYS) |   734 (T)      734 (T)      652          611       |   569          610          510          386       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.199      P=0.346N     P=0.391N     P=0.449    |  P=0.334      P=0.452      P=0.457N     P=0.343    |
|INCIDENTAL TUMOR       |  P=0.203      P=0.346N     P=0.383N     P=0.462    |  P=0.202      P=0.353      P=0.413N     P=0.252    |
|LOGISTIC REGRESSION    |  P=0.203      P=0.346N     P=0.398N     P=0.475    |  P=0.179      P=0.535      P=0.349N     P=0.244    |
|COCHRAN-ARMITAGE       |  P=0.240                                           |  P=0.186                                           |
|FISHER EXACT           |               P=0.309N     P=0.500N     P=0.500    |               P=0.537N     P=0.343N     P=0.274    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    1/50 (2%)    2/50 (4%)    4/50 (8%)  | 25/50 (50%)  23/49 (47%)  24/50 (48%)  29/50 (58%) |
|ADJUSTED (b)           |  17.6%         6.7%         7.6%        21.2%      |  59.2%        68.1%        65.0%        74.0%      |
|TERMINAL (d)           |  3/17 (18%)   1/15 (7%)    1/21 (5%)    2/15 (13%) | 12/28 (43%)  15/25 (60%)  14/26 (54%)  20/30 (67%) |
|FIRST INCIDENCE (DAYS) |   734 (T)      734 (T)      652          611       |   569          526          510          386       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.199      P=0.346N     P=0.391N     P=0.449    |  P=0.324      P=0.511      P=0.528      P=0.348    |
|INCIDENTAL TUMOR       |  P=0.203      P=0.346N     P=0.383N     P=0.462    |  P=0.176      P=0.460      P=0.572      P=0.239    |
|LOGISTIC REGRESSION    |  P=0.203      P=0.346N     P=0.398N     P=0.475    |  P=0.160      P=0.527N     P=0.513N     P=0.242    |
|COCHRAN-ARMITAGE       |  P=0.240                                           |  P=0.168                                           |
|FISHER EXACT           |               P=0.309N     P=0.500N     P=0.500    |               P=0.459N     P=0.500N     P=0.274    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  11
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/49 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   3.6%         8.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  1/28 (4%)    2/25 (8%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   735 (T)      735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.208N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.492      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/49 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   3.6%         8.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  1/28 (4%)    2/25 (8%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   735 (T)      735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.208N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.492      P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  12
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/49 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   3.6%         8.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  1/28 (4%)    2/25 (8%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   735 (T)      735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.192N     P=0.460      P=0.515N     P=0.486N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.208N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.492      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/48 (4%)    1/50 (2%)  |  0/49 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         8.2%         5.3%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    1/21 (5%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          678          693       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.330        (e)        P=0.291      P=0.511    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.320        (e)        P=0.313      P=0.540    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.332        (e)        P=0.271      P=0.495    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.351                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.237      P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  13
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 43/49 (88%)  40/49 (82%)  42/50 (84%)  41/49 (84%) | 40/50 (80%)  39/49 (80%)  38/50 (76%)  40/49 (82%) |
|ADJUSTED (b)           |  97.4%       100.0%        89.3%        95.1%      |  86.8%        95.0%        90.3%        90.8%      |
|TERMINAL (d)           | 15/16 (94%)  15/15 (100%) 16/21 (76%)  13/15 (87%) | 22/28 (79%)  23/25 (92%)  22/26 (85%)  26/30 (87%) |
|FIRST INCIDENCE (DAYS) |   435          471          467          401       |   569          420          510          386       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.455      P=0.340N     P=0.121N     P=0.509N   |  P=0.350N     P=0.336      P=0.530      P=0.491N   |
|INCIDENTAL TUMOR       |  P=0.484N     P=0.294N     P=0.511N     P=0.392N   |  P=0.483      P=0.319      P=0.524N     P=0.348    |
|LOGISTIC REGRESSION    |  P=0.485N     P=0.269N     P=0.376N     P=0.386N   |  P=0.450      P=0.451      P=0.474N     P=0.449    |
|COCHRAN-ARMITAGE       |  P=0.474N                                          |  P=0.450                                           |
|FISHER EXACT           |               P=0.288N     P=0.403N     P=0.387N   |               P=0.579N     P=0.405N     P=0.520    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    4/49 (8%)    1/50 (2%)  |                                                    |
|ADJUSTED (b)           |   5.9%        10.7%        17.1%         6.7%      |                                                    |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    3/21 (14%)   1/15 (7%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   734 (T)      680          673          734 (T)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.537N     P=0.481      P=0.250      P=0.736    |                                                    |
|INCIDENTAL TUMOR       |  P=0.540N     P=0.537      P=0.262      P=0.736    |                                                    |
|LOGISTIC REGRESSION    |  P=0.533N     P=0.508      P=0.251      P=0.736    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |                                                    |
|FISHER EXACT           |               P=0.500      P=0.175      P=0.753N   |                                                    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  14
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.8%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         3.2%      |
|TERMINAL (d)           |  2/17 (12%)   0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      ---          ---          ---       |   ---          ---          ---          722       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.246N     P=0.264N     P=0.191N     P=0.264N   |  P=0.216        (e)          (e)        P=0.494    |
|INCIDENTAL TUMOR       |  P=0.246N     P=0.264N     P=0.191N     P=0.264N   |  P=0.199        (e)          (e)        P=0.484    |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.264N     P=0.191N     P=0.264N   |  P=0.217        (e)          (e)        P=0.493    |
|COCHRAN-ARMITAGE       |  P=0.242N                                          |  P=0.215                                           |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.8%         0.0%         0.0%         6.7%      |   0.0%         0.0%         0.0%         3.2%      |
|TERMINAL (d)           |  2/17 (12%)   0/15 (0%)    0/21 (0%)    1/15 (7%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      ---          ---          734 (T)   |   ---          ---          ---          722       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.680N     P=0.264N     P=0.191N     P=0.545N   |  P=0.216        (e)          (e)        P=0.494    |
|INCIDENTAL TUMOR       |  P=0.680N     P=0.264N     P=0.191N     P=0.545N   |  P=0.199        (e)          (e)        P=0.484    |
|LOGISTIC REGRESSION    |  P=0.680N     P=0.264N     P=0.191N     P=0.545N   |  P=0.217        (e)          (e)        P=0.493    |
|COCHRAN-ARMITAGE       |  P=0.650N                                          |  P=0.215                                           |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.500N   |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  15
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    5/50 (10%)   0/50 (0%)    5/50 (10%) |  1/50 (2%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  22.2%        17.8%         0.0%        33.3%      |   3.6%         0.0%         0.0%         3.2%      |
|TERMINAL (d)           |  3/17 (18%)   1/15 (7%)    0/21 (0%)    5/15 (33%) |  1/28 (4%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   727          589          ---          734 (T)   |   735 (T)      ---          ---          722       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.406      P=0.493      P=0.040N*    P=0.413    |  P=0.551      P=0.523N     P=0.515N     P=0.756N   |
|INCIDENTAL TUMOR       |  P=0.426      P=0.491      P=0.034N*    P=0.441    |  P=0.541      P=0.523N     P=0.515N     P=0.759    |
|LOGISTIC REGRESSION    |  P=0.420      P=0.526      P=0.033N*    P=0.414    |  P=0.538      P=0.523N     P=0.515N     P=0.753    |
|COCHRAN-ARMITAGE       |  P=0.458                                           |  P=0.538                                           |
|FISHER EXACT           |               P=0.500      P=0.059N     P=0.500    |               P=0.505N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         6.3%         7.9%        10.4%      |   0.0%         0.0%         0.0%         3.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    1/21 (5%)    1/15 (7%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          722          673          663       |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.198      P=0.477      P=0.293      P=0.230    |  P=0.236        (e)          (e)        P=0.514    |
|INCIDENTAL TUMOR       |  P=0.192      P=0.615      P=0.313      P=0.247    |  P=0.236        (e)          (e)        P=0.514    |
|LOGISTIC REGRESSION    |  P=0.204      P=0.500      P=0.272      P=0.230    |  P=0.236        (e)          (e)        P=0.514    |
|COCHRAN-ARMITAGE       |  P=0.228                                           |  P=0.215                                           |
|FISHER EXACT           |               P=0.500      P=0.247      P=0.247    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  16
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    2/50 (4%)    5/50 (10%) |  0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%        15.4%         7.9%        25.9%      |   0.0%         0.0%         2.2%         5.5%      |
|TERMINAL (d)           |  0/17 (0%)    1/15 (7%)    1/21 (5%)    2/15 (13%) |  0/28 (0%)    0/25 (0%)    0/26 (0%)    1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          646          673          663       |   ---          ---          568          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.033 *    P=0.120      P=0.293      P=0.031 *  |  P=0.098        (e)        P=0.487      P=0.250    |
|INCIDENTAL TUMOR       |  P=0.026 *    P=0.183      P=0.313      P=0.037 *  |  P=0.069        (e)        P=0.443      P=0.196    |
|LOGISTIC REGRESSION    |  P=0.031 *    P=0.126      P=0.272      P=0.028 *  |  P=0.094        (e)        P=0.543      P=0.239    |
|COCHRAN-ARMITAGE       |  P=0.044 *                                         |  P=0.085                                           |
|FISHER EXACT           |               P=0.121      P=0.247      P=0.028 *  |                 (e)        P=0.500      P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         9.8%         3.3%        12.5%      |   0.0%         0.0%         2.2%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    1/15 (7%)    0/21 (0%)    1/15 (7%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          646          673          720       |   ---          ---          568          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.287      P=0.245      P=0.553      P=0.213    |  P=0.781N       (e)        P=0.487        (e)      |
|INCIDENTAL TUMOR       |  P=0.280      P=0.286      P=0.588      P=0.247    |  P=0.801        (e)        P=0.443        (e)      |
|LOGISTIC REGRESSION    |  P=0.294      P=0.246      P=0.509      P=0.217    |  P=0.742N       (e)        P=0.543        (e)      |
|COCHRAN-ARMITAGE       |  P=0.318                                           |  P=0.785N                                          |
|FISHER EXACT           |               P=0.247      P=0.500      P=0.247    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  17
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/50 (2%)    3/50 (6%)  |  0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         9.8%         3.3%        16.9%      |   0.0%         0.0%         2.2%         2.3%      |
|TERMINAL (d)           |  0/17 (0%)    1/15 (7%)    0/21 (0%)    1/15 (7%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          646          673          692       |   ---          ---          568          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.113      P=0.245      P=0.553      P=0.113    |  P=0.316        (e)        P=0.487      P=0.505    |
|INCIDENTAL TUMOR       |  P=0.101      P=0.286      P=0.588      P=0.136    |  P=0.249        (e)        P=0.443      P=0.406    |
|LOGISTIC REGRESSION    |  P=0.113      P=0.246      P=0.509      P=0.109    |  P=0.354        (e)        P=0.543      P=0.527    |
|COCHRAN-ARMITAGE       |  P=0.132                                           |  P=0.305                                           |
|FISHER EXACT           |               P=0.247      P=0.500      P=0.121    |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   0/50 (0%)    3/50 (6%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.1%        17.8%         0.0%        20.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    0/21 (0%)    3/15 (20%) |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   727          589          ---          734 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.602      P=0.231      P=0.196N     P=0.437    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.601N     P=0.223      P=0.171N     P=0.472    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.608N     P=0.227      P=0.183N     P=0.445    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.582N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.218      P=0.247N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  18
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Lipoma                                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |  2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         6.7%         3.2%         6.7%      |   6.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    1/15 (7%)    0/21 (0%)    1/15 (7%)  |  1/28 (4%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          734 (T)      671          734 (T)   |   709          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.460      P=0.475      P=0.560      P=0.475    |  P=0.238N     P=0.269N     P=0.254N     P=0.242N   |
|INCIDENTAL TUMOR       |  P=0.460      P=0.475      P=0.588      P=0.475    |  P=0.240N     P=0.252N     P=0.240N     P=0.241N   |
|LOGISTIC REGRESSION    |  P=0.467      P=0.475      P=0.508      P=0.475    |  P=0.241N     P=0.264N     P=0.247N     P=0.245N   |
|COCHRAN-ARMITAGE       |  P=0.485                                           |  P=0.241N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500    |               P=0.253N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   0/50 (0%)    4/50 (8%)  |  1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.1%        17.8%         0.0%        26.7%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    0/21 (0%)    4/15 (27%) |  1/28 (4%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   727          589          ---          734 (T)   |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.385      P=0.231      P=0.196N     P=0.272    |  P=0.456N     P=0.523N     P=0.515N     P=0.486N   |
|INCIDENTAL TUMOR       |  P=0.407      P=0.223      P=0.171N     P=0.300    |  P=0.456N     P=0.523N     P=0.515N     P=0.486N   |
|LOGISTIC REGRESSION    |  P=0.400      P=0.227      P=0.183N     P=0.271    |  P=0.456N     P=0.523N     P=0.515N     P=0.486N   |
|COCHRAN-ARMITAGE       |  P=0.429                                           |  P=0.473N                                          |
|FISHER EXACT           |               P=0.218      P=0.247N     P=0.339    |               P=0.505N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  19
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   0/50 (0%)    4/50 (8%)  |  1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.1%        17.8%         0.0%        26.7%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    0/21 (0%)    4/15 (27%) |  1/28 (4%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   727          589          ---          734 (T)   |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.385      P=0.231      P=0.196N     P=0.272    |  P=0.456N     P=0.523N     P=0.515N     P=0.486N   |
|INCIDENTAL TUMOR       |  P=0.407      P=0.223      P=0.171N     P=0.300    |  P=0.456N     P=0.523N     P=0.515N     P=0.486N   |
|LOGISTIC REGRESSION    |  P=0.400      P=0.227      P=0.183N     P=0.271    |  P=0.456N     P=0.523N     P=0.515N     P=0.486N   |
|COCHRAN-ARMITAGE       |  P=0.429                                           |  P=0.473N                                          |
|FISHER EXACT           |               P=0.218      P=0.247N     P=0.339    |               P=0.505N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 35/50 (70%)  31/50 (62%)  33/50 (66%)  29/50 (58%) |                                                    |
|ADJUSTED (b)           |  94.3%        90.5%        88.7%        92.7%      |                                                    |
|TERMINAL (d)           | 15/17 (88%)  12/15 (80%)  17/21 (81%)  13/15 (87%) |                                                    |
|FIRST INCIDENCE (DAYS) |   568          475          534          526       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.369N     P=0.321N     P=0.093N     P=0.319N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.237N     P=0.160N     P=0.272N     P=0.153N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.236N     P=0.142N     P=0.185N     P=0.145N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.179N                                          |                                                    |
|FISHER EXACT           |               P=0.263N     P=0.415N     P=0.149N   |                                                    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  20
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/49 (8%)    2/50 (4%)    3/48 (6%)    4/50 (8%)  |  6/49 (12%)   6/49 (12%)   7/50 (14%)   3/48 (6%)  |
|ADJUSTED (b)           |  18.8%        13.3%        12.1%        20.3%      |  21.4%        19.1%        24.5%         8.3%      |
|TERMINAL (d)           |  2/17 (12%)   2/15 (13%)   2/21 (10%)   2/15 (13%) |  6/28 (21%)   3/25 (12%)   5/26 (19%)   1/30 (3%)  |
|FIRST INCIDENCE (DAYS) |   645          734 (T)      649          586       |   735 (T)      517          722          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.391      P=0.358N     P=0.368N     P=0.602    |  P=0.139N     P=0.540      P=0.449      P=0.220N   |
|INCIDENTAL TUMOR       |  P=0.393      P=0.286N     P=0.334N     P=0.642N   |  P=0.167N     P=0.505N     P=0.469      P=0.264N   |
|LOGISTIC REGRESSION    |  P=0.406      P=0.316N     P=0.426N     P=0.634    |  P=0.177N     P=0.597      P=0.469      P=0.254N   |
|COCHRAN-ARMITAGE       |  P=0.447                                           |  P=0.184N                                          |
|FISHER EXACT           |               P=0.329N     P=0.512N     P=0.631N   |               P=0.620N     P=0.516      P=0.254N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/49 (6%)    3/50 (6%)    4/48 (8%)    3/50 (6%)  |  3/49 (6%)    0/49 (0%)    2/50 (4%)    3/48 (6%)  |
|ADJUSTED (b)           |  12.4%        13.6%        13.6%        15.3%      |  10.0%         0.0%         6.5%         9.3%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    1/21 (5%)    2/15 (13%) |  2/28 (7%)    0/25 (0%)    0/26 (0%)    2/30 (7%)  |
|FIRST INCIDENCE (DAYS) |   435          576          582          562       |   721          ---          709          686       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.569      P=0.647      P=0.597      P=0.631    |  P=0.365      P=0.147N     P=0.528N     P=0.651N   |
|INCIDENTAL TUMOR       |  P=0.596N     P=0.614N     P=0.567      P=0.654N   |  P=0.351      P=0.131N     P=0.471N     P=0.641N   |
|LOGISTIC REGRESSION    |  P=0.587N     P=0.656N     P=0.479      P=0.655N   |  P=0.340      P=0.140N     P=0.511N     P=0.653    |
|COCHRAN-ARMITAGE       |  P=0.582N                                          |  P=0.323                                           |
|FISHER EXACT           |               P=0.651N     P=0.488      P=0.651N   |               P=0.121N     P=0.490N     P=0.651    |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  21
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/49 (14%)   5/50 (10%)   6/48 (13%)   7/50 (14%) |  9/49 (18%)   6/49 (12%)   9/50 (18%)   6/48 (13%) |
|ADJUSTED (b)           |  29.5%        25.9%        22.3%        34.1%      |  30.7%        19.1%        29.4%        17.0%      |
|TERMINAL (d)           |  3/17 (18%)   3/15 (20%)   3/21 (14%)   4/15 (27%) |  8/28 (29%)   3/25 (12%)   5/26 (19%)   3/30 (10%) |
|FIRST INCIDENCE (DAYS) |   435          576          582          562       |   721          517          709          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.394      P=0.408N     P=0.349N     P=0.558    |  P=0.277N     P=0.376N     P=0.543      P=0.263N   |
|INCIDENTAL TUMOR       |  P=0.420      P=0.306N     P=0.349N     P=0.606N   |  P=0.320N     P=0.198N     P=0.595      P=0.294N   |
|LOGISTIC REGRESSION    |  P=0.430      P=0.353N     P=0.479N     P=0.609    |  P=0.339N     P=0.326N     P=0.578      P=0.303N   |
|COCHRAN-ARMITAGE       |  P=0.466                                           |  P=0.357N                                          |
|FISHER EXACT           |               P=0.365N     P=0.516N     P=0.597N   |               P=0.288N     P=0.584N     P=0.303N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    2/50 (4%)    0/48 (0%)    0/50 (0%)  |  0/49 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)  |
|ADJUSTED (b)           |   5.9%        12.2%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      719          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.217N     P=0.464      P=0.458N     P=0.525N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.215N     P=0.537      P=0.458N     P=0.525N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.211N     P=0.484      P=0.458N     P=0.525N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.208N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.508      P=0.505N     P=0.495N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  22
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    3/50 (6%)    0/48 (0%)    1/50 (2%)  |  0/49 (0%)    1/49 (2%)    0/50 (0%)    1/48 (2%)  |
|ADJUSTED (b)           |   5.9%        16.0%         0.0%         6.7%      |   0.0%         2.3%         0.0%         2.4%      |
|TERMINAL (d)           |  1/17 (6%)    1/15 (7%)    0/21 (0%)    1/15 (7%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      680          ---          734 (T)   |   ---          526          ---          652       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453N     P=0.288      P=0.458N     P=0.736    |  P=0.468      P=0.479        (e)        P=0.500    |
|INCIDENTAL TUMOR       |  P=0.454N     P=0.384      P=0.458N     P=0.736    |  P=0.410      P=0.846        (e)        P=0.500    |
|LOGISTIC REGRESSION    |  P=0.448N     P=0.309      P=0.458N     P=0.736    |  P=0.525      P=0.610        (e)        P=0.511    |
|COCHRAN-ARMITAGE       |  P=0.423N                                          |  P=0.458                                           |
|FISHER EXACT           |               P=0.316      P=0.505N     P=0.747N   |               P=0.500        (e)        P=0.495    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  8/50 (16%)   7/49 (14%)  11/50 (22%)   4/50 (8%)  |
|ADJUSTED (b)           |                                                    |  23.9%        20.0%        35.6%        13.3%      |
|TERMINAL (d)           |                                                    |  5/28 (18%)   3/25 (12%)   8/26 (31%)   4/30 (13%) |
|FIRST INCIDENCE (DAYS) |                                                    |   569          483          600          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.113N     P=0.585N     P=0.254      P=0.159N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.143N     P=0.503N     P=0.221      P=0.193N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.146N     P=0.467N     P=0.294      P=0.189N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.144N                                          |
|FISHER EXACT           |                                                    |               P=0.517N     P=0.306      P=0.178N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  23
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/50 (2%)    2/49 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   3.1%         4.4%         0.0%         0.0%      |
|TERMINAL (d)           |                                                    |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   727          362          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.209N     P=0.470      P=0.520N     P=0.513N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.177N     P=0.686      P=0.485N     P=0.516N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.130N     P=0.646      P=0.510N     P=0.509N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.208N                                          |
|FISHER EXACT           |                                                    |               P=0.492      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  9/50 (18%)   9/49 (18%)  11/50 (22%)   4/50 (8%)  |
|ADJUSTED (b)           |                                                    |  26.3%        23.6%        35.6%        13.3%      |
|TERMINAL (d)           |                                                    |  5/28 (18%)   3/25 (12%)   8/26 (31%)   4/30 (13%) |
|FIRST INCIDENCE (DAYS) |                                                    |   569          362          600          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.059N     P=0.507      P=0.341      P=0.108N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.069N     P=0.539N     P=0.313      P=0.132N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.071N     P=0.513N     P=0.387      P=0.126N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.074N                                          |
|FISHER EXACT           |                                                    |               P=0.584      P=0.402      P=0.117N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  24
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    1/49 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.2%         0.0%         0.0%         4.4%      |   0.0%         2.4%         3.4%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   527          ---          ---          401       |   ---          610          727          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.185      P=0.500N     P=0.509N     P=0.492    |  P=0.526N     P=0.486      P=0.480        (e)      |
|INCIDENTAL TUMOR       |  P=0.236      P=0.536N     P=0.500N     P=0.530    |  P=0.573N     P=0.362      P=0.515        (e)      |
|LOGISTIC REGRESSION    |  P=0.201      P=0.497N     P=0.458N     P=0.592    |  P=0.528N     P=0.550      P=0.490        (e)      |
|COCHRAN-ARMITAGE       |  P=0.189                                           |  P=0.534N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500    |               P=0.495      P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/50 (60%)  32/50 (64%)  29/50 (58%)  28/50 (56%) | 15/50 (30%)  16/49 (33%)  19/50 (38%)  10/50 (20%) |
|ADJUSTED (b)           |  77.3%        80.6%        74.9%        75.6%      |  37.4%        41.1%        47.7%        25.6%      |
|TERMINAL (d)           |  9/17 (53%)   8/15 (53%)  12/21 (57%)   8/15 (53%) |  5/28 (18%)   5/25 (20%)   7/26 (27%)   3/30 (10%) |
|FIRST INCIDENCE (DAYS) |   453          475          435          463       |   385          483          526          470       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.468N     P=0.501      P=0.199N     P=0.507N   |  P=0.107N     P=0.367      P=0.242      P=0.217N   |
|INCIDENTAL TUMOR       |  P=0.306N     P=0.509      P=0.571N     P=0.425N   |  P=0.130N     P=0.523      P=0.295      P=0.162N   |
|LOGISTIC REGRESSION    |  P=0.313N     P=0.433      P=0.467N     P=0.420N   |  P=0.091N     P=0.529      P=0.273      P=0.166N   |
|COCHRAN-ARMITAGE       |  P=0.297N                                          |  P=0.095N                                          |
|FISHER EXACT           |               P=0.418      P=0.500N     P=0.420N   |               P=0.473      P=0.263      P=0.178N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  25
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.2%        11.1%         6.5%         9.3%      |   0.0%         2.4%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    1/15 (7%)    0/21 (0%)    1/15 (7%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   589          681          649          603       |   ---          610          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.523N     P=0.477N     P=0.397N     P=0.517N   |  P=0.563N     P=0.486        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.507N     P=0.454N     P=0.523N     P=0.509N   |  P=0.615N     P=0.362        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.498N     P=0.494N     P=0.507N     P=0.501N   |  P=0.541N     P=0.550        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.491N                                          |  P=0.575N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.495        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        11.4%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          631          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.258N     P=0.146        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.261N     P=0.173        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.257N     P=0.123        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.255N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.121        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  26
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        11.4%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/15 (0%)    0/21 (0%)    0/15 (0%)  |  0/28 (0%)    0/25 (0%)    0/26 (0%)    0/30 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          631          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.258N     P=0.146        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.261N     P=0.173        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.257N     P=0.123        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.255N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.121        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/50 (96%)  46/50 (92%)  47/50 (94%)  48/50 (96%) | 45/50 (90%)  44/49 (90%)  47/50 (94%)  44/50 (88%) |
|ADJUSTED (b)           |  97.9%       100.0%        97.9%       100.0%      |  93.7%        95.6%       100.0%        97.8%      |
|TERMINAL (d)           | 16/17 (94%)  15/15 (100%) 20/21 (95%)  15/15 (100%)| 25/28 (89%)  23/25 (92%)  26/26 (100%) 29/30 (97%) |
|FIRST INCIDENCE (DAYS) |   435          471          467          401       |   569          420          510          386       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.317      P=0.419N     P=0.125N     P=0.437    |  P=0.259N     P=0.318      P=0.275      P=0.420N   |
|INCIDENTAL TUMOR       |  P=0.410      P=0.361N     P=0.665N     P=0.685N   |  P=0.440N     P=0.439      P=0.125      P=0.601    |
|LOGISTIC REGRESSION    |  P=0.385      P=0.319N     P=0.517N     P=0.687    |  P=0.483N     P=0.566      P=0.248      P=0.636N   |
|COCHRAN-ARMITAGE       |  P=0.434                                           |  P=0.418N                                          |
|FISHER EXACT           |               P=0.339N     P=0.500N     P=0.691N   |               P=0.617N     P=0.357      P=0.500N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  27
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.3          1.0          3.0       |   CONTROL      0.3          1.0          3.0       |
|                       |                MG/M3        MG/M3        MG/M3     |                MG/M3        MG/M3        MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 38/50 (76%)  42/50 (84%)  35/50 (70%)  38/50 (76%) | 25/50 (50%)  23/49 (47%)  32/50 (64%)  27/50 (54%) |
|ADJUSTED (b)           |  89.9%        93.1%        78.9%        87.5%      |  58.3%        54.9%        72.0%        65.0%      |
|TERMINAL (d)           | 13/17 (76%)  12/15 (80%)  12/21 (57%)  10/15 (67%) | 11/28 (39%)   8/25 (32%)  14/26 (54%)  16/30 (53%) |
|FIRST INCIDENCE (DAYS) |   435          408          272          401       |   385          362          355          470       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.490      P=0.386      P=0.115N     P=0.469    |  P=0.472      P=0.513      P=0.129      P=0.464    |
|INCIDENTAL TUMOR       |  P=0.413N     P=0.317      P=0.249N     P=0.565N   |  P=0.296      P=0.380N     P=0.141      P=0.370    |
|LOGISTIC REGRESSION    |  P=0.396N     P=0.241      P=0.329N     P=0.592N   |  P=0.341      P=0.376N     P=0.119      P=0.402    |
|COCHRAN-ARMITAGE       |  P=0.395N                                          |  P=0.337                                           |
|FISHER EXACT           |               P=0.227      P=0.326N     P=0.592N   |               P=0.459N     P=0.113      P=0.421    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)| 48/50 (96%)  47/49 (96%)  50/50 (100%) 46/50 (92%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  96.0%        95.9%       100.0%        97.9%      |
|TERMINAL (d)           | 17/17 (100%) 15/15 (100%) 21/21 (100%) 15/15 (100%)| 26/28 (93%)  23/25 (92%)  26/26 (100%) 29/30 (97%) |
|FIRST INCIDENCE (DAYS) |   435          408          272          401       |   385          362          355          386       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.361      P=0.510N     P=0.146N     P=0.438    |  P=0.216N     P=0.310      P=0.280      P=0.365N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.224N     P=0.655N     P=0.254      P=0.470N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.228N     P=0.655N     P=0.254      P=0.450N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.180N                                          |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=1.000N   |               P=0.684N     P=0.247      P=0.339N   |
|=================================================================================================================================|
         DATE: 07/25/96                     EXPERIMENT: 05156 TEST: 05                                                 PAGE  28
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1  COBALT SULFATE HEPTAHYDRATE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).