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TDMS Study 05158-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 04                                                                                     TIME: 02:49:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: R. MILLER                                                                                         CAS: 1313-27-5       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 04                                                                                     TIME: 02:49:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: R. MILLER                                                                                         CAS: 1313-27-5       




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 04                                                                                     TIME: 02:49:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: R. MILLER                                                                                         CAS: 1313-27-5       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF MOLYBDENUM TRIOXIDE

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              All Organs                    Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hemangiosarcoma
                                            Hepatocellular Carcinoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Pituitary Gland: Pars Intermedia
                                            Adenoma
              Skin                          Sarcoma
              Uterus                        Polyp Stromal
              All Organs                    Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/49 (2%)    2/48 (4%)    0/50 (0%)  |  1/50 (2%)    1/50 (2%)    1/49 (2%)    0/49 (0%)  |
|ADJUSTED (b)           |   2.8%         2.4%         8.0%         0.0%      |   3.4%         3.2%         2.5%         0.0%      |
|TERMINAL (d)           |  1/36 (3%)    0/33 (0%)    2/25 (8%)    0/37 (0%)  |  0/25 (0%)    1/31 (3%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      692          733 (T)      ---       |   720          733 (T)      705          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.313N     P=0.759      P=0.373      P=0.495N   |  P=0.294N     P=0.722N     P=0.710N     P=0.462N   |
|INCIDENTAL TUMOR       |  P=0.326N     P=0.680N     P=0.373      P=0.495N   |  P=0.354N     P=0.751      P=0.746N     P=0.590N   |
|LOGISTIC REGRESSION    |  P=0.314N     P=0.758N     P=0.373      P=0.495N   |  P=0.315N     P=0.738N     P=0.746N     P=0.480N   |
|COCHRAN-ARMITAGE       |  P=0.323N                                          |  P=0.332N                                          |
|FISHER EXACT           |               P=0.747      P=0.485      P=0.500N   |               P=0.753N     P=0.747      P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    4/50 (8%)    2/50 (4%)  |  2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.8%         9.8%        15.1%         5.4%      |   6.8%         6.5%         0.0%         0.0%      |
|TERMINAL (d)           |  1/36 (3%)    1/33 (3%)    3/25 (12%)   2/37 (5%)  |  1/25 (4%)    2/31 (6%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      580          715          733 (T)   |   692          733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.488N     P=0.184      P=0.094      P=0.510    |  P=0.109N     P=0.627N     P=0.190N     P=0.192N   |
|INCIDENTAL TUMOR       |  P=0.525N     P=0.263      P=0.135      P=0.510    |  P=0.118N     P=0.665N     P=0.201N     P=0.248N   |
|LOGISTIC REGRESSION    |  P=0.517N     P=0.168      P=0.121      P=0.510    |  P=0.123N     P=0.660N     P=0.212N     P=0.223N   |
|COCHRAN-ARMITAGE       |  P=0.532N                                          |  P=0.136N                                          |
|FISHER EXACT           |               P=0.181      P=0.181      P=0.500    |               P=0.691N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.6%         0.0%         0.0%         2.4%      |   2.9%         0.0%         2.4%         2.7%      |
|TERMINAL (d)           |  2/36 (6%)    0/33 (0%)    0/25 (0%)    0/37 (0%)  |  0/25 (0%)    0/31 (0%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          677       |   692          ---          689          699       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.643N     P=0.258N     P=0.322N     P=0.482N   |  P=0.581      P=0.483N     P=0.715N     P=0.728N   |
|INCIDENTAL TUMOR       |  P=0.682N     P=0.258N     P=0.322N     P=0.473N   |  P=0.467      P=0.564N     P=0.746N     P=0.661    |
|LOGISTIC REGRESSION    |  P=0.662N     P=0.258N     P=0.322N     P=0.488N   |  P=0.559      P=0.499N     P=0.762      P=0.761N   |
|COCHRAN-ARMITAGE       |  P=0.673N                                          |  P=0.559                                           |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.500N   |               P=0.500N     P=0.753N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    4/50 (8%)    3/50 (6%)  |  3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   8.3%         9.8%        15.1%         7.7%      |   9.6%         6.5%         2.4%         2.7%      |
|TERMINAL (d)           |  3/36 (8%)    1/33 (3%)    3/25 (12%)   2/37 (5%)  |  1/25 (4%)    2/31 (6%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      580          715          677       |   692          733 (T)      689          699       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.465N     P=0.486      P=0.315      P=0.644N   |  P=0.232N     P=0.427N     P=0.235N     P=0.245N   |
|INCIDENTAL TUMOR       |  P=0.514N     P=0.590      P=0.388      P=0.637N   |  P=0.298N     P=0.499N     P=0.255N     P=0.394N   |
|LOGISTIC REGRESSION    |  P=0.497N     P=0.506      P=0.380      P=0.640N   |  P=0.271N     P=0.466N     P=0.289N     P=0.503N   |
|COCHRAN-ARMITAGE       |  P=0.514N                                          |  P=0.277N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.661N   |               P=0.500N     P=0.309N     P=0.309N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/48 (4%)    0/48 (0%)    1/50 (2%)  |  1/50 (2%)    0/49 (0%)    0/48 (0%)    1/46 (2%)  |
|ADJUSTED (b)           |   0.0%         6.1%         0.0%         2.7%      |   4.0%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/36 (0%)    2/33 (6%)    0/25 (0%)    1/37 (3%)  |  1/25 (4%)    0/31 (0%)    0/33 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      ---          733 (T)   |   733 (T)      ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.635      P=0.219        (e)        P=0.505    |  P=0.588      P=0.457N     P=0.445N     P=0.685N   |
|INCIDENTAL TUMOR       |  P=0.635      P=0.219        (e)        P=0.505    |  P=0.588      P=0.457N     P=0.445N     P=0.685N   |
|LOGISTIC REGRESSION    |  P=0.635      P=0.219        (e)        P=0.505    |  P=0.588      P=0.457N     P=0.445N     P=0.685N   |
|COCHRAN-ARMITAGE       |  P=0.621                                           |  P=0.520                                           |
|FISHER EXACT           |               P=0.237        (e)        P=0.500    |               P=0.505N     P=0.510N     P=0.731    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/48 (6%)    0/48 (0%)    1/50 (2%)  |  1/50 (2%)    0/49 (0%)    1/48 (2%)    2/46 (4%)  |
|ADJUSTED (b)           |   0.0%         9.1%         0.0%         2.7%      |   4.0%         0.0%         3.0%         5.0%      |
|TERMINAL (d)           |  0/36 (0%)    3/33 (9%)    0/25 (0%)    1/37 (3%)  |  1/25 (4%)    0/31 (0%)    1/33 (3%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      ---          733 (T)   |   733 (T)      ---          733 (T)      534       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.593N     P=0.106        (e)        P=0.505    |  P=0.284      P=0.457N     P=0.699N     P=0.570    |
|INCIDENTAL TUMOR       |  P=0.593N     P=0.106        (e)        P=0.505    |  P=0.242      P=0.457N     P=0.699N     P=0.500    |
|LOGISTIC REGRESSION    |  P=0.593N     P=0.106        (e)        P=0.505    |  P=0.214      P=0.457N     P=0.699N     P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.620N                                          |  P=0.217                                           |
|FISHER EXACT           |               P=0.114        (e)        P=0.500    |               P=0.505N     P=0.742      P=0.468    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.6%         0.0%      |   0.0%         0.0%         0.0%         5.2%      |
|TERMINAL (d)           |  0/36 (0%)    0/33 (0%)    0/25 (0%)    0/37 (0%)  |  0/25 (0%)    0/31 (0%)    0/33 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          715          ---       |   ---          ---          ---          664       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.754N       (e)        P=0.450        (e)      |  P=0.053        (e)          (e)        P=0.292    |
|INCIDENTAL TUMOR       |  P=0.851N       (e)        P=0.657        (e)      |  P=0.035 *      (e)          (e)        P=0.223    |
|LOGISTIC REGRESSION    |  P=0.772N       (e)        P=0.475        (e)      |  P=0.040 *      (e)          (e)        P=0.237    |
|COCHRAN-ARMITAGE       |  P=0.779N                                          |  P=0.040 *                                         |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |                 (e)          (e)        P=0.242    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/50 (40%)  15/50 (30%)  19/50 (38%)  19/50 (38%) |  9/50 (18%)  11/50 (22%)  13/50 (26%)  16/49 (33%) |
|ADJUSTED (b)           |  50.5%        37.9%        64.1%        48.4%      |  32.2%        31.5%        35.2%        45.7%      |
|TERMINAL (d)           | 17/36 (47%)   9/33 (27%)  15/25 (60%)  17/37 (46%) |  7/25 (28%)   8/31 (26%)  10/33 (30%)  16/35 (46%) |
|FIRST INCIDENCE (DAYS) |   433          689          513          580       |   562          629          638          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.510N     P=0.273N     P=0.201      P=0.458N   |  P=0.213      P=0.586      P=0.482      P=0.304    |
|INCIDENTAL TUMOR       |  P=0.479      P=0.206N     P=0.371      P=0.574    |  P=0.107      P=0.473      P=0.352      P=0.215    |
|LOGISTIC REGRESSION    |  P=0.497      P=0.183N     P=0.557      P=0.469N   |  P=0.093      P=0.471      P=0.352      P=0.151    |
|COCHRAN-ARMITAGE       |  P=0.455                                           |  P=0.061                                           |
|FISHER EXACT           |               P=0.201N     P=0.500N     P=0.500N   |               P=0.402      P=0.235      P=0.074    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/50 (24%)  18/50 (36%)  21/50 (42%)  13/50 (26%) | 19/50 (38%)  12/50 (24%)  16/50 (32%)  11/49 (22%) |
|ADJUSTED (b)           |  27.0%        42.0%        46.6%        28.3%      |  49.9%        31.9%        38.3%        26.3%      |
|TERMINAL (d)           |  5/36 (14%)  10/33 (30%)   5/25 (20%)   5/37 (14%) |  8/25 (32%)   7/31 (23%)   9/33 (27%)   6/35 (17%) |
|FIRST INCIDENCE (DAYS) |   350          448          365          408       |   469          600          562          350       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.310N     P=0.162      P=0.028 *    P=0.541    |  P=0.065N     P=0.053N     P=0.147N     P=0.028N*  |
|INCIDENTAL TUMOR       |  P=0.442N     P=0.100      P=0.153      P=0.515    |  P=0.207N     P=0.145N     P=0.476N     P=0.086N   |
|LOGISTIC REGRESSION    |  P=0.492N     P=0.072      P=0.133      P=0.372    |  P=0.138N     P=0.099N     P=0.395N     P=0.080N   |
|COCHRAN-ARMITAGE       |  P=0.356N                                          |  P=0.134N                                          |
|FISHER EXACT           |               P=0.138      P=0.044 *    P=0.500    |               P=0.097N     P=0.338N     P=0.071N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/50 (60%)  27/50 (54%)  34/50 (68%)  28/50 (56%) | 23/50 (46%)  22/50 (44%)  25/50 (50%)  27/49 (55%) |
|ADJUSTED (b)           |  66.1%        60.4%        79.3%        60.6%      |  61.7%        57.1%        59.7%        67.0%      |
|TERMINAL (d)           | 21/36 (58%)  16/33 (48%)  17/25 (68%)  19/37 (51%) | 12/25 (48%)  15/31 (48%)  17/33 (52%)  22/35 (63%) |
|FIRST INCIDENCE (DAYS) |   350          448          365          408       |   469          600          562          350       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.314N     P=0.435N     P=0.044 *    P=0.375N   |  P=0.535      P=0.251N     P=0.333N     P=0.415N   |
|INCIDENTAL TUMOR       |  P=0.474N     P=0.441N     P=0.256      P=0.462N   |  P=0.192      P=0.510N     P=0.374      P=0.427    |
|LOGISTIC REGRESSION    |  P=0.479N     P=0.410N     P=0.361      P=0.451N   |  P=0.168      P=0.477N     P=0.426      P=0.248    |
|COCHRAN-ARMITAGE       |  P=0.441N                                          |  P=0.161                                           |
|FISHER EXACT           |               P=0.343N     P=0.266      P=0.420N   |               P=0.500N     P=0.421      P=0.241    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/50 (60%)  27/50 (54%)  34/50 (68%)  28/50 (56%) | 23/50 (46%)  22/50 (44%)  25/50 (50%)  27/49 (55%) |
|ADJUSTED (b)           |  66.1%        60.4%        79.3%        60.6%      |  61.7%        57.1%        59.7%        67.0%      |
|TERMINAL (d)           | 21/36 (58%)  16/33 (48%)  17/25 (68%)  19/37 (51%) | 12/25 (48%)  15/31 (48%)  17/33 (52%)  22/35 (63%) |
|FIRST INCIDENCE (DAYS) |   350          448          365          408       |   469          600          562          350       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.314N     P=0.435N     P=0.044 *    P=0.375N   |  P=0.535      P=0.251N     P=0.333N     P=0.415N   |
|INCIDENTAL TUMOR       |  P=0.474N     P=0.441N     P=0.256      P=0.462N   |  P=0.192      P=0.510N     P=0.374      P=0.427    |
|LOGISTIC REGRESSION    |  P=0.479N     P=0.410N     P=0.361      P=0.451N   |  P=0.168      P=0.477N     P=0.426      P=0.248    |
|COCHRAN-ARMITAGE       |  P=0.441N                                          |  P=0.161                                           |
|FISHER EXACT           |               P=0.343N     P=0.266      P=0.420N   |               P=0.500N     P=0.421      P=0.241    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)  14/50 (28%)  10/49 (20%)   9/50 (18%) |  1/50 (2%)    4/50 (8%)    8/49 (16%)   9/49 (18%) |
|ADJUSTED (b)           |  23.5%        37.8%        29.8%        22.5%      |   3.7%        11.0%        23.5%        24.8%      |
|TERMINAL (d)           |  7/36 (19%)  11/33 (33%)   5/25 (20%)   7/37 (19%) |  0/25 (0%)    2/31 (6%)    7/33 (21%)   8/35 (23%) |
|FIRST INCIDENCE (DAYS) |   651          653          440          576       |   729          610          720          667       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272N     P=0.146      P=0.270      P=0.570N   |  P=0.042 *    P=0.236      P=0.045 *    P=0.032 *  |
|INCIDENTAL TUMOR       |  P=0.338N     P=0.265      P=0.511      P=0.544N   |  P=0.019 *    P=0.145      P=0.041 *    P=0.019 *  |
|LOGISTIC REGRESSION    |  P=0.322N     P=0.205      P=0.464      P=0.571N   |  P=0.018 *    P=0.184      P=0.036 *    P=0.016 *  |
|COCHRAN-ARMITAGE       |  P=0.335N                                          |  P=0.013 *                                         |
|FISHER EXACT           |               P=0.171      P=0.480      P=0.602N   |               P=0.181      P=0.014 *    P=0.007 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)   16/50 (32%)  14/49 (29%)  10/50 (20%) |  2/50 (4%)    2/50 (4%)    0/49 (0%)    6/49 (12%) |
|ADJUSTED (b)           |   4.9%        40.7%        43.3%        25.3%      |   5.8%         5.2%         0.0%        16.3%      |
|TERMINAL (d)           |  1/36 (3%)   11/33 (33%)   8/25 (32%)   8/37 (22%) |  0/25 (0%)    0/31 (0%)    0/33 (0%)    5/35 (14%) |
|FIRST INCIDENCE (DAYS) |   544          580          513          629       |   642          629          ---          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.462      P<0.001 **   P<0.001 **   P=0.020 *  |  P=0.044 *    P=0.655N     P=0.192N     P=0.235    |
|INCIDENTAL TUMOR       |  P=0.382      P<0.001 **   P=0.002 **   P=0.013 *  |  P=0.005 **   P=0.559      P=0.364N     P=0.065    |
|LOGISTIC REGRESSION    |  P=0.385      P<0.001 **   P<0.001 **   P=0.017 *  |  P=0.024 *    P=0.694      P=0.256N     P=0.140    |
|COCHRAN-ARMITAGE       |  P=0.371                                           |  P=0.024 *                                         |
|FISHER EXACT           |               P<0.001 **   P<0.001 **   P=0.014 *  |               P=0.691N     P=0.253N     P=0.128    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/50 (22%)  27/50 (54%)  21/49 (43%)  18/50 (36%) |  3/50 (6%)    6/50 (12%)   8/49 (16%)  15/49 (31%) |
|ADJUSTED (b)           |  27.7%        64.8%        56.1%        43.4%      |   9.3%        15.6%        23.5%        40.1%      |
|TERMINAL (d)           |  8/36 (22%)  19/33 (58%)  10/25 (40%)  14/37 (38%) |  0/25 (0%)    2/31 (6%)    7/33 (21%)  13/35 (37%) |
|FIRST INCIDENCE (DAYS) |   544          580          440          576       |   642          610          720          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.432N     P=0.001 **   P=0.005 **   P=0.123    |  P=0.004 **   P=0.320      P=0.205      P=0.015 *  |
|INCIDENTAL TUMOR       |  P=0.538      P=0.002 **   P=0.044 *    P=0.105    |  P<0.001 **   P=0.139      P=0.128      P=0.001 ** |
|LOGISTIC REGRESSION    |  P=0.541N     P=0.001 **   P=0.020 *    P=0.106    |  P<0.001 **   P=0.223      P=0.152      P=0.003 ** |
|COCHRAN-ARMITAGE       |  P=0.547                                           |  P<0.001 **                                        |
|FISHER EXACT           |               P<0.001 **   P=0.022 *    P=0.093    |               P=0.243      P=0.094      P=0.001 ** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         6.5%         2.0%         0.0%      |
|TERMINAL (d)           |  0/36 (0%)    0/33 (0%)    0/25 (0%)    0/37 (0%)  |  0/25 (0%)    2/31 (6%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          733 (T)      288          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.345N     P=0.286      P=0.500        (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.190N     P=0.286        (e)          (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.312N     P=0.286        (e)          (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.383N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.247      P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/50 (2%)    2/49 (4%)    3/48 (6%)    0/46 (0%)  |
|ADJUSTED (b)           |                                                    |   3.4%         6.5%         8.4%         0.0%      |
|TERMINAL (d)           |                                                    |  0/25 (0%)    2/31 (6%)    2/33 (6%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   720          733 (T)      692          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.195N     P=0.565      P=0.393      P=0.462N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.234N     P=0.498      P=0.356      P=0.621N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.225N     P=0.543      P=0.349      P=0.486N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.266N                                          |
|FISHER EXACT           |                                                    |               P=0.492      P=0.293      P=0.521N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/47 (0%)    0/47 (0%)    0/46 (0%)    0/47 (0%)  |  9/49 (18%)   8/48 (17%)   9/48 (19%)   9/49 (18%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  28.1%        25.4%        22.4%        24.9%      |
|TERMINAL (d)           |  0/34 (0%)    0/31 (0%)    0/24 (0%)    0/36 (0%)  |  5/25 (20%)   6/29 (21%)   3/32 (9%)    8/35 (23%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   511          709          670          698       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.410N     P=0.384N     P=0.414N     P=0.361N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.543N     P=0.482N     P=0.598N     P=0.487N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.564N     P=0.491N     P=0.596      P=0.563N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.529                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.519N     P=0.584      P=0.603N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/47 (0%)    0/47 (0%)    0/46 (0%)    0/47 (0%)  |  9/49 (18%)   8/48 (17%)  10/48 (21%)   9/49 (18%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  28.1%        25.4%        25.1%        24.9%      |
|TERMINAL (d)           |  0/34 (0%)    0/31 (0%)    0/24 (0%)    0/36 (0%)  |  5/25 (20%)   6/29 (21%)   4/32 (13%)   8/35 (23%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   511          709          670          698       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.395N     P=0.384N     P=0.499N     P=0.361N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.524N     P=0.482N     P=0.525      P=0.487N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.551N     P=0.491N     P=0.500      P=0.563N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.539                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.519N     P=0.480      P=0.603N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/47 (0%)    1/47 (2%)    0/46 (0%)    2/47 (4%)  |  0/49 (0%)    0/48 (0%)    0/48 (0%)    2/49 (4%)  |
|ADJUSTED (b)           |   0.0%         2.4%         0.0%         5.1%      |   0.0%         0.0%         0.0%         5.7%      |
|TERMINAL (d)           |  0/34 (0%)    0/31 (0%)    0/24 (0%)    1/36 (3%)  |  0/25 (0%)    0/29 (0%)    0/32 (0%)    2/35 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          689          ---          686       |   ---          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.170      P=0.520        (e)        P=0.254    |  P=0.063        (e)          (e)        P=0.315    |
|INCIDENTAL TUMOR       |  P=0.112      P=0.674        (e)        P=0.266    |  P=0.063        (e)          (e)        P=0.315    |
|LOGISTIC REGRESSION    |  P=0.154      P=0.495        (e)        P=0.244    |  P=0.063        (e)          (e)        P=0.315    |
|COCHRAN-ARMITAGE       |  P=0.149                                           |  P=0.043 *                                         |
|FISHER EXACT           |               P=0.500        (e)        P=0.247    |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    3/50 (6%)    4/50 (8%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.0%         0.0%      |   0.0%         3.2%         7.5%        10.2%      |
|TERMINAL (d)           |  0/36 (0%)    0/33 (0%)    1/25 (4%)    0/37 (0%)  |  0/25 (0%)    1/31 (3%)    0/33 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      ---       |   ---          733 (T)      653          664       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.756N       (e)        P=0.427        (e)      |  P=0.065      P=0.543      P=0.165      P=0.095    |
|INCIDENTAL TUMOR       |  P=0.756N       (e)        P=0.427        (e)      |  P=0.017 *    P=0.543      P=0.129      P=0.030 *  |
|LOGISTIC REGRESSION    |  P=0.756N       (e)        P=0.427        (e)      |  P=0.027 *    P=0.543      P=0.118      P=0.064    |
|COCHRAN-ARMITAGE       |  P=0.779N                                          |  P=0.044 *                                         |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.500      P=0.121      P=0.059    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.7%      |   0.0%         0.0%         5.9%         0.0%      |
|TERMINAL (d)           |  0/36 (0%)    0/33 (0%)    0/25 (0%)    1/37 (3%)  |  0/25 (0%)    0/31 (0%)    1/33 (3%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          733 (T)   |   ---          ---          723          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.244        (e)          (e)        P=0.505    |  P=0.630N       (e)        P=0.297        (e)      |
|INCIDENTAL TUMOR       |  P=0.244        (e)          (e)        P=0.505    |  P=0.689N       (e)        P=0.280        (e)      |
|LOGISTIC REGRESSION    |  P=0.244        (e)          (e)        P=0.505    |  P=0.654N       (e)        P=0.284        (e)      |
|COCHRAN-ARMITAGE       |  P=0.221                                           |  P=0.675N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)    2/49 (4%)    1/50 (2%)  |  2/50 (4%)    2/50 (4%)    1/49 (2%)    2/49 (4%)  |
|ADJUSTED (b)           |   2.8%         8.2%         8.0%         2.7%      |   8.0%         5.8%         3.0%         5.7%      |
|TERMINAL (d)           |  1/36 (3%)    2/33 (6%)    2/25 (8%)    1/37 (3%)  |  2/25 (8%)    1/31 (3%)    1/33 (3%)    2/35 (6%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      664          733 (T)      733 (T)   |   733 (T)      681          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.388N     P=0.294      P=0.373      P=0.756N   |  P=0.565N     P=0.624N     P=0.403N     P=0.569N   |
|INCIDENTAL TUMOR       |  P=0.408N     P=0.361      P=0.373      P=0.756N   |  P=0.588N     P=0.665N     P=0.403N     P=0.569N   |
|LOGISTIC REGRESSION    |  P=0.403N     P=0.321      P=0.373      P=0.756N   |  P=0.620N     P=0.664N     P=0.403N     P=0.569N   |
|COCHRAN-ARMITAGE       |  P=0.421N                                          |  P=0.608                                           |
|FISHER EXACT           |               P=0.309      P=0.492      P=0.753N   |               P=0.691N     P=0.508N     P=0.684    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    2/49 (4%)    1/50 (2%)  |  2/50 (4%)    2/50 (4%)    1/49 (2%)    2/49 (4%)  |
|ADJUSTED (b)           |   5.6%         8.2%         8.0%         2.7%      |   8.0%         5.8%         3.0%         5.7%      |
|TERMINAL (d)           |  2/36 (6%)    2/33 (6%)    2/25 (8%)    1/37 (3%)  |  2/25 (8%)    1/31 (3%)    1/33 (3%)    2/35 (6%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      664          733 (T)      733 (T)   |   733 (T)      681          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.278N     P=0.480      P=0.558      P=0.490N   |  P=0.565N     P=0.624N     P=0.403N     P=0.569N   |
|INCIDENTAL TUMOR       |  P=0.293N     P=0.550      P=0.558      P=0.490N   |  P=0.588N     P=0.665N     P=0.403N     P=0.569N   |
|LOGISTIC REGRESSION    |  P=0.289N     P=0.522      P=0.558      P=0.490N   |  P=0.620N     P=0.664N     P=0.403N     P=0.569N   |
|COCHRAN-ARMITAGE       |  P=0.305N                                          |  P=0.608                                           |
|FISHER EXACT           |               P=0.500      P=0.684      P=0.500N   |               P=0.691N     P=0.508N     P=0.684    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/50 (8%)    3/50 (6%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |                                                    |  16.0%         9.1%         0.0%         8.6%      |
|TERMINAL (d)           |                                                    |  4/25 (16%)   2/31 (6%)    0/33 (0%)    3/35 (9%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   733 (T)      709          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.435N     P=0.388N     P=0.033N*    P=0.319N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.456N     P=0.424N     P=0.033N*    P=0.319N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.481N     P=0.427N     P=0.033N*    P=0.319N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.550N                                          |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.059N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   2.8%         0.0%         7.4%         0.0%      |   0.0%         2.2%         0.0%         8.0%      |
|TERMINAL (d)           |  1/36 (3%)    0/33 (0%)    1/25 (4%)    0/37 (0%)  |  0/25 (0%)    0/31 (0%)    0/33 (0%)    2/35 (6%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          715          ---       |   ---          594          ---          664       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.417N     P=0.517N     P=0.388      P=0.495N   |  P=0.054      P=0.523        (e)        P=0.174    |
|INCIDENTAL TUMOR       |  P=0.451N     P=0.517N     P=0.503      P=0.495N   |  P=0.017 *    P=0.419        (e)        P=0.132    |
|LOGISTIC REGRESSION    |  P=0.427N     P=0.517N     P=0.436      P=0.495N   |  P=0.041 *    P=0.530        (e)        P=0.127    |
|COCHRAN-ARMITAGE       |  P=0.441N                                          |  P=0.040 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |               P=0.500        (e)        P=0.121    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)  |
|ADJUSTED (b)           |   2.8%         0.0%        11.3%         2.7%      |   0.0%         2.2%         3.0%         8.0%      |
|TERMINAL (d)           |  1/36 (3%)    0/33 (0%)    2/25 (8%)    1/37 (3%)  |  0/25 (0%)    0/31 (0%)    1/33 (3%)    2/35 (6%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          715          733 (T)   |   ---          594          733 (T)      664       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.620      P=0.517N     P=0.196      P=0.756N   |  P=0.091      P=0.523      P=0.555      P=0.174    |
|INCIDENTAL TUMOR       |  P=0.596      P=0.517N     P=0.271      P=0.756N   |  P=0.039 *    P=0.419      P=0.555      P=0.132    |
|LOGISTIC REGRESSION    |  P=0.612      P=0.517N     P=0.236      P=0.756N   |  P=0.066      P=0.530      P=0.555      P=0.127    |
|COCHRAN-ARMITAGE       |  P=0.592                                           |  P=0.066                                           |
|FISHER EXACT           |               P=0.500N     P=0.309      P=0.753N   |               P=0.500      P=0.500      P=0.121    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/50 (8%)    0/50 (0%)    1/50 (2%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.6%        12.1%         0.0%         2.7%      |   3.3%         2.9%         0.0%         2.4%      |
|TERMINAL (d)           |  2/36 (6%)    4/33 (12%)   0/25 (0%)    1/37 (3%)  |  0/25 (0%)    0/31 (0%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      ---          733 (T)   |   709          709          ---          650       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.224N     P=0.296      P=0.322N     P=0.490N   |  P=0.698      P=0.727N     P=0.453N     P=0.723N   |
|INCIDENTAL TUMOR       |  P=0.225N     P=0.296      P=0.322N     P=0.490N   |  P=0.600      P=0.693      P=0.483N     P=0.661    |
|LOGISTIC REGRESSION    |  P=0.225N     P=0.296      P=0.322N     P=0.490N   |  P=0.673      P=0.753N     P=0.484N     P=0.762N   |
|COCHRAN-ARMITAGE       |  P=0.245N                                          |  P=0.673                                           |
|FISHER EXACT           |               P=0.339      P=0.247N     P=0.500N   |               P=0.753N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)  |  3/50 (6%)    5/50 (10%)   8/50 (16%)   6/50 (12%) |
|ADJUSTED (b)           |   5.6%         5.3%         5.1%         4.6%      |  10.4%        12.9%        19.9%        16.3%      |
|TERMINAL (d)           |  2/36 (6%)    1/33 (3%)    0/25 (0%)    1/37 (3%)  |  2/25 (8%)    2/31 (6%)    3/33 (9%)    5/35 (14%) |
|FIRST INCIDENCE (DAYS) |   733 (T)      664          442          328       |   636          592          603          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.594N     P=0.681      P=0.615      P=0.686N   |  P=0.436      P=0.444      P=0.203      P=0.398    |
|INCIDENTAL TUMOR       |  P=0.613      P=0.639N     P=0.624N     P=0.686N   |  P=0.131      P=0.302      P=0.089      P=0.197    |
|LOGISTIC REGRESSION    |  P=0.617      P=0.679N     P=0.673N     P=0.668    |  P=0.309      P=0.354      P=0.108      P=0.264    |
|COCHRAN-ARMITAGE       |  P=0.627                                           |  P=0.311                                           |
|FISHER EXACT           |               P=0.691N     P=0.691N     P=0.691N   |               P=0.357      P=0.100      P=0.243    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.8%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/36 (0%)    0/33 (0%)    0/25 (0%)    0/37 (0%)  |  0/25 (0%)    0/31 (0%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   581          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.260N     P=0.227N     P=0.215N     P=0.232N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.546N     P=0.328N     P=0.500N     P=0.674N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.228N     P=0.209N     P=0.241N     P=0.197N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.262N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.247N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.8%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/36 (0%)    0/33 (0%)    0/25 (0%)    0/37 (0%)  |  0/25 (0%)    0/31 (0%)    0/33 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   581          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.260N     P=0.227N     P=0.215N     P=0.232N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.546N     P=0.328N     P=0.500N     P=0.674N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.228N     P=0.209N     P=0.241N     P=0.197N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.262N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.247N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 28/50 (56%)  26/50 (52%)  28/50 (56%)  28/50 (56%) | 25/50 (50%)  24/50 (48%)  30/50 (60%)  26/50 (52%) |
|ADJUSTED (b)           |  67.8%        58.8%        83.9%        66.3%      |  72.2%        62.7%        69.6%        70.2%      |
|TERMINAL (d)           | 23/36 (64%)  15/33 (45%)  20/25 (80%)  23/37 (62%) | 16/25 (64%)  17/31 (55%)  20/33 (61%)  24/35 (69%) |
|FIRST INCIDENCE (DAYS) |   433          580          440          576       |   511          610          638          667       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.432N     P=0.516N     P=0.075      P=0.513N   |  P=0.230N     P=0.212N     P=0.453N     P=0.145N   |
|INCIDENTAL TUMOR       |  P=0.471      P=0.282N     P=0.311      P=0.542    |  P=0.541N     P=0.421N     P=0.380      P=0.396N   |
|LOGISTIC REGRESSION    |  P=0.522      P=0.371N     P=0.452      P=0.532N   |  P=0.532      P=0.409N     P=0.382      P=0.542N   |
|COCHRAN-ARMITAGE       |  P=0.478                                           |  P=0.457                                           |
|FISHER EXACT           |               P=0.421N     P=0.580N     P=0.580N   |               P=0.500N     P=0.211      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/50 (40%)  36/50 (72%)  35/50 (70%)  24/50 (48%) | 28/50 (56%)  25/50 (50%)  29/50 (58%)  25/50 (50%) |
|ADJUSTED (b)           |  44.7%        77.6%        73.3%        49.7%      |  62.8%        55.6%        59.1%        54.0%      |
|TERMINAL (d)           | 12/36 (33%)  23/33 (70%)  13/25 (52%)  13/37 (35%) |  9/25 (36%)  12/31 (39%)  13/33 (39%)  14/35 (40%) |
|FIRST INCIDENCE (DAYS) |   350          448          365          328       |   469          220          288          350       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.209N     P=0.006 **   P=0.001 **   P=0.356    |  P=0.194N     P=0.196N     P=0.281N     P=0.140N   |
|INCIDENTAL TUMOR       |  P=0.302N     P<0.001 **   P=0.010 *    P=0.259    |  P=0.411      P=0.500N     P=0.314      P=0.423    |
|LOGISTIC REGRESSION    |  P=0.337N     P<0.001 **   P=0.006 **   P=0.209    |  P=0.549N     P=0.408N     P=0.319      P=0.513    |
|COCHRAN-ARMITAGE       |  P=0.255N                                          |  P=0.372N                                          |
|FISHER EXACT           |               P=0.001 **   P=0.002 **   P=0.273    |               P=0.344N     P=0.500      P=0.344N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 04                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/50 (80%)  44/50 (88%)  45/50 (90%)  42/50 (84%) | 40/50 (80%)  39/50 (78%)  43/50 (86%)  40/50 (80%) |
|ADJUSTED (b)           |  84.9%        89.7%        93.5%        84.0%      |  84.8%        84.5%        86.0%        85.1%      |
|TERMINAL (d)           | 29/36 (81%)  28/33 (85%)  22/25 (88%)  29/37 (78%) | 18/25 (72%)  24/31 (77%)  26/33 (79%)  28/35 (80%) |
|FIRST INCIDENCE (DAYS) |   350          448          365          328       |   469          220          288          350       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.331N     P=0.223      P=0.012 *    P=0.522    |  P=0.159N     P=0.186N     P=0.225N     P=0.113N   |
|INCIDENTAL TUMOR       |  P=0.528      P=0.156      P=0.143      P=0.349    |  P=0.385      P=0.541N     P=0.205      P=0.393    |
|LOGISTIC REGRESSION    |  P=0.516      P=0.178      P=0.189      P=0.357    |  P=0.542      P=0.520N     P=0.212      P=0.586    |
|COCHRAN-ARMITAGE       |  P=0.561                                           |  P=0.546                                           |
|FISHER EXACT           |               P=0.207      P=0.131      P=0.398    |               P=0.500N     P=0.298      P=0.598N   |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).