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TDMS Study 05158-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 03                                                                                     TIME: 02:09:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0001313-27-5    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 03                                                                                     TIME: 02:09:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0001313-27-5    




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 03                                                                                     TIME: 02:09:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0001313-27-5    




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                     IN THE ANALYSIS OF THE STUDY OF 7-5MOLYBDENUM TRIOXIDE

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Skin                          Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
                                            Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
              Spleen                        Fibroma
              All Organs                    Benign Tumors

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Clitoral/Preputial Gland      Carcinoma or Adenoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   1
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |  1/49 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         9.7%         0.0%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    1/16 (6%)    0/17 (0%)  |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          665          ---       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.611N       (e)        P=0.237        (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.586N       (e)        P=0.251        (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.629N       (e)        P=0.239        (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.675N                                          |  P=0.497N                                          |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |               P=0.500N     P=0.495N     P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/50 (30%)  11/50 (22%)  17/50 (34%)  17/50 (34%) |  5/49 (10%)   0/49 (0%)    4/50 (8%)    6/50 (12%) |
|ADJUSTED (b)           |  60.4%        66.3%        58.1%        56.7%      |  14.3%         0.0%        10.7%        20.7%      |
|TERMINAL (d)           |  8/17 (47%)   5/10 (50%)   6/16 (38%)   6/17 (35%) |  2/28 (7%)    0/24 (0%)    0/24 (0%)    3/23 (13%) |
|FIRST INCIDENCE (DAYS) |   559          622          525          598       |   680          ---          583          555       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.532N     P=0.473      P=0.398      P=0.539    |  P=0.093      P=0.055N     P=0.563N     P=0.363    |
|INCIDENTAL TUMOR       |  P=0.542      P=0.433N     P=0.437      P=0.553N   |  P=0.165      P=0.048N*    P=0.427N     P=0.512    |
|LOGISTIC REGRESSION    |  P=0.476      P=0.503N     P=0.430      P=0.566    |  P=0.142      P=0.035N*    P=0.371N     P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.232                                           |  P=0.143                                           |
|FISHER EXACT           |               P=0.247N     P=0.415      P=0.415    |               P=0.028N*    P=0.487N     P=0.514    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   2
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |  0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.9%         5.6%         2.6%         9.4%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    0/10 (0%)    0/16 (0%)    1/17 (6%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   629          684          594          692       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.616      P=0.613N     P=0.487N     P=0.656N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.553      P=0.525N     P=0.507N     P=0.693N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.566      P=0.556N     P=0.500N     P=0.660N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.521                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.691N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/50 (30%)  13/50 (26%)  18/50 (36%)  18/50 (36%) |  6/49 (12%)   0/49 (0%)    4/50 (8%)    6/50 (12%) |
|ADJUSTED (b)           |  60.4%        70.6%        59.2%        60.6%      |  17.6%         0.0%        10.7%        20.7%      |
|TERMINAL (d)           |  8/17 (47%)   5/10 (50%)   6/16 (38%)   7/17 (41%) |  3/28 (11%)   0/24 (0%)    0/24 (0%)    3/23 (13%) |
|FIRST INCIDENCE (DAYS) |   559          622          525          598       |   680          ---          583          555       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.524N     P=0.288      P=0.331      P=0.461    |  P=0.143      P=0.032N*    P=0.444N     P=0.472    |
|INCIDENTAL TUMOR       |  P=0.546      P=0.583      P=0.353      P=0.537    |  P=0.235      P=0.028N*    P=0.313N     P=0.624    |
|LOGISTIC REGRESSION    |  P=0.474      P=0.476      P=0.345      P=0.487    |  P=0.207      P=0.020N*    P=0.268N     P=0.598    |
|COCHRAN-ARMITAGE       |  P=0.225                                           |  P=0.212                                           |
|FISHER EXACT           |               P=0.412N     P=0.335      P=0.335    |               P=0.013N*    P=0.357N     P=0.606N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   3
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    3/50 (6%)    3/50 (6%)  |  2/44 (5%)    6/48 (13%)   5/47 (11%)   1/47 (2%)  |
|ADJUSTED (b)           |  11.8%        23.8%        18.8%        13.7%      |   6.9%        21.2%        17.6%         2.9%      |
|TERMINAL (d)           |  2/17 (12%)   2/10 (20%)   3/16 (19%)   1/17 (6%)  |  1/26 (4%)    4/23 (17%)   3/23 (13%)   0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      660          735 (T)      696       |   716          573          653          637       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.593N     P=0.290      P=0.471      P=0.520    |  P=0.217N     P=0.109      P=0.176      P=0.575N   |
|INCIDENTAL TUMOR       |  P=0.556N     P=0.323      P=0.471      P=0.607    |  P=0.133N     P=0.204      P=0.216      P=0.397N   |
|LOGISTIC REGRESSION    |  P=0.574N     P=0.353      P=0.471      P=0.562    |  P=0.156N     P=0.152      P=0.215      P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.500                                           |  P=0.141N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500    |               P=0.164      P=0.245      P=0.475N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    1/50 (2%)    1/50 (2%)  |  1/44 (2%)    1/48 (2%)    5/47 (11%)   2/47 (4%)  |
|ADJUSTED (b)           |  12.2%        21.3%         6.3%         5.9%      |   3.8%         3.7%        19.3%         9.5%      |
|TERMINAL (d)           |  1/17 (6%)    1/10 (10%)   1/16 (6%)    1/17 (6%)  |  1/26 (4%)    0/23 (0%)    3/23 (13%)   2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   553          622          735 (T)      735 (T)   |   735 (T)      721          721          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.164N     P=0.498      P=0.318N     P=0.287N   |  P=0.388      P=0.735      P=0.083      P=0.425    |
|INCIDENTAL TUMOR       |  P=0.183N     P=0.629      P=0.303N     P=0.300N   |  P=0.376      P=0.747      P=0.097      P=0.425    |
|LOGISTIC REGRESSION    |  P=0.167N     P=0.598      P=0.302N     P=0.288N   |  P=0.367      P=0.738      P=0.077      P=0.425    |
|COCHRAN-ARMITAGE       |  P=0.216N                                          |  P=0.479                                           |
|FISHER EXACT           |               P=0.661N     P=0.309N     P=0.309N   |               P=0.731N     P=0.117      P=0.525    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   4
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   6/50 (12%)   4/50 (8%)    4/50 (8%)  |  3/44 (7%)    7/48 (15%)  10/47 (21%)   3/47 (6%)  |
|ADJUSTED (b)           |  23.1%        41.7%        25.0%        19.1%      |  10.6%        24.1%        35.0%        12.2%      |
|TERMINAL (d)           |  3/17 (18%)   3/10 (30%)   4/16 (25%)   2/17 (12%) |  2/26 (8%)    4/23 (17%)   6/23 (26%)   2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   553          622          735 (T)      696       |   716          573          653          637       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.245N     P=0.241      P=0.530N     P=0.469N   |  P=0.405N     P=0.126      P=0.025 *    P=0.559    |
|INCIDENTAL TUMOR       |  P=0.240N     P=0.349      P=0.519N     P=0.416N   |  P=0.307N     P=0.223      P=0.033 *    P=0.652N   |
|LOGISTIC REGRESSION    |  P=0.227N     P=0.352      P=0.496N     P=0.428N   |  P=0.343N     P=0.172      P=0.027 *    P=0.606    |
|COCHRAN-ARMITAGE       |  P=0.379N                                          |  P=0.265N                                          |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.500N   |               P=0.196      P=0.046 *    P=0.629N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   1/49 (2%)    4/49 (8%)  |  1/49 (2%)    0/49 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.2%        32.4%         6.3%        13.4%      |   3.0%         0.0%         4.2%         4.3%      |
|TERMINAL (d)           |  1/17 (6%)    2/10 (20%)   1/16 (6%)    1/17 (6%)  |  0/28 (0%)    0/24 (0%)    1/24 (4%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   581          581          735 (T)      567       |   716          ---          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.450N     P=0.124      P=0.308N     P=0.569    |  P=0.519      P=0.533N     P=0.725      P=0.711    |
|INCIDENTAL TUMOR       |  P=0.576      P=0.200      P=0.330N     P=0.462    |  P=0.510      P=0.531N     P=0.751      P=0.700    |
|LOGISTIC REGRESSION    |  P=0.572N     P=0.202      P=0.309N     P=0.489    |  P=0.509      P=0.516N     P=0.738      P=0.712    |
|COCHRAN-ARMITAGE       |  P=0.587                                           |  P=0.564                                           |
|FISHER EXACT           |               P=0.243      P=0.316N     P=0.489    |               P=0.500N     P=0.747N     P=0.747N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   5
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    2/49 (4%)    4/49 (8%)  |  0/49 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   4.2%        20.0%        12.5%        20.0%      |   0.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  0/17 (0%)    2/10 (20%)   2/16 (13%)   2/17 (12%) |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   678          735 (T)      735 (T)      715       |   ---          ---          ---          652       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.202      P=0.346      P=0.476      P=0.207    |  P=0.188        (e)          (e)        P=0.446    |
|INCIDENTAL TUMOR       |  P=0.239      P=0.397      P=0.505      P=0.297    |  P=0.171        (e)          (e)        P=0.433    |
|LOGISTIC REGRESSION    |  P=0.214      P=0.395      P=0.497      P=0.219    |  P=0.226        (e)          (e)        P=0.506    |
|COCHRAN-ARMITAGE       |  P=0.123                                           |  P=0.223                                           |
|FISHER EXACT           |               P=0.500      P=0.492      P=0.175    |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    7/50 (14%)   3/49 (6%)    8/49 (16%) |  1/49 (2%)    0/49 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |  14.9%        40.8%        18.8%        31.3%      |   3.0%         0.0%         4.2%         7.3%      |
|TERMINAL (d)           |  1/17 (6%)    3/10 (30%)   3/16 (19%)   3/17 (18%) |  0/28 (0%)    0/24 (0%)    1/24 (4%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   581          581          735 (T)      567       |   716          ---          735 (T)      652       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.346      P=0.119      P=0.517N     P=0.244    |  P=0.197      P=0.533N     P=0.725      P=0.419    |
|INCIDENTAL TUMOR       |  P=0.242      P=0.205      P=0.517N     P=0.228    |  P=0.181      P=0.531N     P=0.751      P=0.399    |
|LOGISTIC REGRESSION    |  P=0.267      P=0.201      P=0.503N     P=0.192    |  P=0.212      P=0.516N     P=0.738      P=0.481    |
|COCHRAN-ARMITAGE       |  P=0.174                                           |  P=0.244                                           |
|FISHER EXACT           |               P=0.262      P=0.511N     P=0.168    |               P=0.500N     P=0.747N     P=0.508    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   6
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.6%         5.3%        11.8%        11.8%      |   0.0%         0.0%         0.0%         4.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    1/16 (6%)    2/17 (12%) |  0/28 (0%)    0/24 (0%)    0/24 (0%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   729          675          729          735 (T)   |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.480      P=0.678      P=0.480      P=0.500    |  P=0.202        (e)          (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.546      P=0.727N     P=0.532      P=0.568    |  P=0.202        (e)          (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.500      P=0.712      P=0.489      P=0.519    |  P=0.202        (e)          (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.395                                           |  P=0.222                                           |
|FISHER EXACT           |               P=0.753N     P=0.500      P=0.500    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    1/49 (2%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.6%         5.3%        11.8%        11.8%      |   0.0%         4.2%         3.6%         4.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    1/16 (6%)    2/17 (12%) |  0/28 (0%)    1/24 (4%)    0/24 (0%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   729          675          729          735 (T)   |   ---          735 (T)      721          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.480      P=0.678      P=0.480      P=0.500    |  P=0.461      P=0.469      P=0.486      P=0.461    |
|INCIDENTAL TUMOR       |  P=0.546      P=0.727N     P=0.532      P=0.568    |  P=0.449      P=0.469      P=0.514      P=0.461    |
|LOGISTIC REGRESSION    |  P=0.500      P=0.712      P=0.489      P=0.519    |  P=0.448      P=0.469      P=0.481      P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.395                                           |  P=0.502                                           |
|FISHER EXACT           |               P=0.753N     P=0.500      P=0.500    |               P=0.495      P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   7
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.8%        10.0%         6.3%        11.8%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/17 (12%)   1/10 (10%)   1/16 (6%)    2/17 (12%) |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      735 (T)      735 (T)      735 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.596      P=0.686N     P=0.522N     P=0.700    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.596      P=0.686N     P=0.522N     P=0.700    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.596      P=0.686N     P=0.522N     P=0.700    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.521                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.691N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    1/50 (2%)    3/50 (6%)  |  1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.8%        13.8%         6.3%        14.0%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/17 (12%)   1/10 (10%)   1/16 (6%)    2/17 (12%) |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      634          735 (T)      621       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.475      P=0.527      P=0.522N     P=0.518    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.374      P=0.561      P=0.522N     P=0.449    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.481      P=0.598      P=0.522N     P=0.562    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.373                                           |  P=0.499N                                          |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.500    |               P=0.505N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   8
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    1/50 (2%)    3/50 (6%)  |  1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.8%        13.8%         6.3%        14.0%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/17 (12%)   1/10 (10%)   1/16 (6%)    2/17 (12%) |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      634          735 (T)      621       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.475      P=0.527      P=0.522N     P=0.518    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.374      P=0.561      P=0.522N     P=0.449    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.481      P=0.598      P=0.522N     P=0.562    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.373                                           |  P=0.499N                                          |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.500    |               P=0.505N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        14.8%      |   0.0%         4.2%         0.0%         7.1%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    1/17 (6%)  |  0/28 (0%)    1/24 (4%)    0/24 (0%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          717       |   ---          735 (T)      ---          636       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.017 *      (e)          (e)        P=0.133    |  P=0.124      P=0.469        (e)        P=0.197    |
|INCIDENTAL TUMOR       |  P=0.027 *      (e)          (e)        P=0.197    |  P=0.192      P=0.469        (e)        P=0.354    |
|LOGISTIC REGRESSION    |  P=0.017 *      (e)          (e)        P=0.140    |  P=0.135      P=0.469        (e)        P=0.234    |
|COCHRAN-ARMITAGE       |  P=0.009 **                                        |  P=0.149                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.121    |               P=0.500        (e)        P=0.247    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE   9
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    4/50 (8%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         5.3%         4.3%        17.4%      |   0.0%         8.3%         0.0%         7.1%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    1/17 (6%)  |  0/28 (0%)    2/24 (8%)    0/24 (0%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          675          677          665       |   ---          735 (T)      ---          636       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.048 *    P=0.453      P=0.492      P=0.080    |  P=0.241      P=0.204        (e)        P=0.197    |
|INCIDENTAL TUMOR       |  P=0.071      P=0.533      P=0.533      P=0.130    |  P=0.317      P=0.204        (e)        P=0.354    |
|LOGISTIC REGRESSION    |  P=0.034 *    P=0.473      P=0.502      P=0.078    |  P=0.250      P=0.204        (e)        P=0.234    |
|COCHRAN-ARMITAGE       |  P=0.019 *                                         |  P=0.280                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.059    |               P=0.247        (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    3/50 (6%)    3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%        10.6%        12.5%         2.9%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    2/24 (8%)    3/24 (13%)   0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          618          735 (T)      636       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.595N     P=0.101      P=0.094      P=0.459    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.472N     P=0.164      P=0.094      P=0.788    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.571N     P=0.118      P=0.094      P=0.496    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.539N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.121      P=0.121      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  10
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.1%         8.3%         6.6%        11.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    2/24 (8%)    1/24 (4%)    2/23 (9%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   464          735 (T)      615          636       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.233      P=0.469      P=0.476      P=0.260    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.336      P=0.431      P=0.566      P=0.381    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.277      P=0.484      P=0.482      P=0.301    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.274                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500      P=0.500      P=0.309    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    5/50 (10%)   5/50 (10%)   3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.1%        18.8%        18.8%        11.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    4/24 (17%)   4/24 (17%)   2/23 (9%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   464          618          615          636       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.499      P=0.083      P=0.082      P=0.260    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.565N     P=0.108      P=0.108      P=0.381    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.555      P=0.102      P=0.104      P=0.301    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.570                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.102      P=0.102      P=0.309    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  11
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  | 22/50 (44%)  32/50 (64%)  28/50 (56%)  18/50 (36%) |
|ADJUSTED (b)           |   0.0%         0.0%        10.0%         2.4%      |  61.8%        83.5%        76.4%        63.6%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  | 15/28 (54%)  18/24 (75%)  16/24 (67%)  13/23 (57%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          706          598       |   534          485          464          618       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.452        (e)        P=0.234      P=0.536    |  P=0.165N     P=0.014 *    P=0.073      P=0.580    |
|INCIDENTAL TUMOR       |  P=0.441        (e)        P=0.273      P=0.388    |  P=0.069N     P=0.012 *    P=0.127      P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.411        (e)        P=0.237      P=0.506    |  P=0.062N     P=0.023 *    P=0.126      P=0.529N   |
|COCHRAN-ARMITAGE       |  P=0.383                                           |  P=0.034N*                                         |
|FISHER EXACT           |                 (e)        P=0.247      P=0.500    |               P=0.035 *    P=0.159      P=0.270N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  | 22/50 (44%)  33/50 (66%)  29/50 (58%)  19/50 (38%) |
|ADJUSTED (b)           |   0.0%         0.0%        10.0%         2.4%      |  61.8%        84.0%        79.4%        64.7%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  | 15/28 (54%)  18/24 (75%)  17/24 (71%)  13/23 (57%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          706          598       |   534          485          464          618       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.452        (e)        P=0.234      P=0.536    |  P=0.205N     P=0.010 **   P=0.049 *    P=0.492    |
|INCIDENTAL TUMOR       |  P=0.441        (e)        P=0.273      P=0.388    |  P=0.076N     P=0.010 *    P=0.086      P=0.532N   |
|LOGISTIC REGRESSION    |  P=0.411        (e)        P=0.237      P=0.506    |  P=0.077N     P=0.015 *    P=0.086      P=0.580    |
|COCHRAN-ARMITAGE       |  P=0.383                                           |  P=0.044N*                                         |
|FISHER EXACT           |                 (e)        P=0.247      P=0.500    |               P=0.022 *    P=0.115      P=0.342N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  12
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  | 23/50 (46%)  33/50 (66%)  30/50 (60%)  20/50 (40%) |
|ADJUSTED (b)           |   0.0%         0.0%        10.0%         2.4%      |  62.6%        84.0%        79.9%        68.2%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  | 15/28 (54%)  18/24 (75%)  17/24 (71%)  14/23 (61%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          706          598       |   464          485          464          618       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.452        (e)        P=0.234      P=0.536    |  P=0.235N     P=0.016 *    P=0.054      P=0.486    |
|INCIDENTAL TUMOR       |  P=0.441        (e)        P=0.273      P=0.388    |  P=0.084N     P=0.016 *    P=0.098      P=0.540N   |
|LOGISTIC REGRESSION    |  P=0.411        (e)        P=0.237      P=0.506    |  P=0.084N     P=0.029 *    P=0.099      P=0.533N   |
|COCHRAN-ARMITAGE       |  P=0.383                                           |  P=0.053N                                          |
|FISHER EXACT           |                 (e)        P=0.247      P=0.500    |               P=0.035 *    P=0.115      P=0.343N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.9%         0.0%         2.6%         4.5%      |   7.1%         0.0%         3.7%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  2/28 (7%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      ---          594          715       |   735 (T)      ---          729          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.617      P=0.606N     P=0.758N     P=0.750N   |  P=0.307N     P=0.272N     P=0.544N     P=0.282N   |
|INCIDENTAL TUMOR       |  P=0.581      P=0.606N     P=0.754      P=0.696N   |  P=0.313N     P=0.272N     P=0.528N     P=0.282N   |
|LOGISTIC REGRESSION    |  P=0.593      P=0.606N     P=0.762N     P=0.737N   |  P=0.311N     P=0.272N     P=0.548N     P=0.282N   |
|COCHRAN-ARMITAGE       |  P=0.559                                           |  P=0.276N                                          |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.753N   |               P=0.247N     P=0.500N     P=0.247N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  13
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |  0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.9%        10.0%        12.5%         4.8%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/10 (10%)   2/16 (13%)   0/17 (0%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      735 (T)      735 (T)      717       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.561N     P=0.640      P=0.478      P=0.749N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.539N     P=0.640      P=0.478      P=0.696N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.553N     P=0.640      P=0.478      P=0.738N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.636N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.753N     P=0.500      P=0.753N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 37/49 (76%)  39/50 (78%)  40/50 (80%)  36/48 (75%) | 43/49 (88%)  39/50 (78%)  40/50 (80%)  38/50 (76%) |
|ADJUSTED (b)           |  89.6%       100.0%        97.4%        97.0%      |  97.7%        86.1%        88.6%        84.2%      |
|TERMINAL (d)           | 13/17 (76%)  10/10 (100%) 15/16 (94%)  16/17 (94%) | 27/28 (96%)  18/24 (75%)  19/24 (79%)  16/23 (70%) |
|FIRST INCIDENCE (DAYS) |   425          274          454          497       |   534          485          464          527       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.071N     P=0.054      P=0.373      P=0.331N   |  P=0.397      P=0.467      P=0.414      P=0.390    |
|INCIDENTAL TUMOR       |  P=0.329N     P=0.409      P=0.286      P=0.575    |  P=0.167N     P=0.067N     P=0.253N     P=0.119N   |
|LOGISTIC REGRESSION    |  P=0.319N     P=0.366      P=0.381      P=0.505N   |  P=0.203N     P=0.143N     P=0.246N     P=0.032N*  |
|COCHRAN-ARMITAGE       |  P=0.462N                                          |  P=0.177N                                          |
|FISHER EXACT           |               P=0.478      P=0.384      P=0.570N   |               P=0.154N     P=0.220N     P=0.104N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  14
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        18.2%         0.0%         0.0%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    1/10 (10%)   0/16 (0%)    0/17 (0%)  |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          730          ---          ---       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.354N     P=0.142        (e)          (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.321N     P=0.198        (e)          (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.349N     P=0.145        (e)          (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.392N                                          |  P=0.500N                                          |
|FISHER EXACT           |               P=0.247        (e)          (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        18.2%         2.6%         0.0%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    1/10 (10%)   0/16 (0%)    0/17 (0%)  |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          730          585          ---       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.334N     P=0.142      P=0.516        (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.362N     P=0.198      P=0.500        (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.350N     P=0.145      P=0.508        (e)      |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.383N                                          |  P=0.500N                                          |
|FISHER EXACT           |               P=0.247      P=0.500        (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  15
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    6/50 (12%)   2/50 (4%)    5/50 (10%) |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.9%        35.5%         8.0%        22.7%      |   7.1%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/10 (10%)   0/16 (0%)    3/17 (18%) |  2/28 (7%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   629          553          585          618       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.480      P=0.060      P=0.682N     P=0.256    |  P=0.284N     P=0.272N     P=0.272N     P=0.282N   |
|INCIDENTAL TUMOR       |  P=0.436      P=0.127      P=0.684N     P=0.185    |  P=0.284N     P=0.272N     P=0.272N     P=0.282N   |
|LOGISTIC REGRESSION    |  P=0.437      P=0.081      P=0.693N     P=0.255    |  P=0.284N     P=0.272N     P=0.272N     P=0.282N   |
|COCHRAN-ARMITAGE       |  P=0.340                                           |  P=0.262N                                          |
|FISHER EXACT           |               P=0.134      P=0.691N     P=0.218    |               P=0.247N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    3/50 (6%)    4/50 (8%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.2%        14.7%        15.5%        20.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    2/16 (13%)   2/17 (12%) |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   665          629          653          696       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.561      P=0.511      P=0.648      P=0.540    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.564N     P=0.591N     P=0.623N     P=0.589N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.538      P=0.664N     P=0.661N     P=0.576    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.413                                           |    (e)                                             |
|FISHER EXACT           |               P=0.661N     P=0.661N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  16
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    3/50 (6%)    6/50 (12%) |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.2%        14.7%        15.5%        23.7%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    2/16 (13%)   2/17 (12%) |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   665          629          653          406       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.253      P=0.511      P=0.648      P=0.287    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.239      P=0.591N     P=0.623N     P=0.322    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.175      P=0.664N     P=0.661N     P=0.252    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.136                                           |    (e)                                             |
|FISHER EXACT           |               P=0.661N     P=0.661N     P=0.243    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.0%         0.0%         4.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          629          ---          406       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.185      P=0.457        (e)        P=0.253    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.035 *    P=0.527        (e)        P=0.094    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.162      P=0.501        (e)        P=0.276    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.149                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500        (e)        P=0.247    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  17
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.9%        21.1%         5.6%        11.8%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    0/10 (0%)    0/16 (0%)    2/17 (12%) |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      553          727          735 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.504N     P=0.108      P=0.754      P=0.500    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.456N     P=0.184      P=0.749N     P=0.500    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.497N     P=0.133      P=0.759      P=0.500    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.591N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.181      P=0.753N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.2%         0.0%         0.0%         6.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   629          ---          ---          618       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.262      P=0.543N     P=0.482N     P=0.572    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.141      P=0.473N     P=0.500N     P=0.438    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.188      P=0.499N     P=0.500N     P=0.499    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.186                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  18
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous Tumor                                                           |
|     (malignant or NOS), or Carcinoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.2%        18.2%         0.0%         6.1%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    1/10 (10%)   0/16 (0%)    0/17 (0%)  |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   629          730          ---          618       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.550      P=0.366      P=0.482N     P=0.572    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.474      P=0.475      P=0.500N     P=0.438    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.499      P=0.424      P=0.500N     P=0.499    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.454                                           |  P=0.500N                                          |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.500    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   1/50 (2%)    5/50 (10%) |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.9%        29.0%         5.6%        22.7%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/10 (10%)   0/16 (0%)    3/17 (18%) |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   629          553          727          618       |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.377      P=0.117      P=0.496N     P=0.256    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.347      P=0.200      P=0.488N     P=0.185    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.348      P=0.155      P=0.496N     P=0.255    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.254                                           |  P=0.500N                                          |
|FISHER EXACT           |               P=0.218      P=0.500N     P=0.218    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  19
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    5/50 (10%)   1/50 (2%)    3/50 (6%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.9%        29.0%         5.6%        17.6%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    1/10 (10%)   0/16 (0%)    3/17 (18%) |  1/28 (4%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      553          727          735 (T)   |   735 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.610      P=0.048 *    P=0.754      P=0.300    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.569N     P=0.086      P=0.749N     P=0.300    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.591N     P=0.063      P=0.759      P=0.300    |  P=0.521N     P=0.531N     P=0.531N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.517                                           |  P=0.500N                                          |
|FISHER EXACT           |               P=0.102      P=0.753N     P=0.309    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |  0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         6.8%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          679       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.078        (e)          (e)        P=0.292    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.098        (e)          (e)        P=0.376    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.051        (e)          (e)        P=0.247    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.042 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.247    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  20
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 39/50 (78%)  32/50 (64%)  36/50 (72%)  38/50 (76%) |                                                    |
|ADJUSTED (b)           |  97.3%        96.5%        97.1%       100.0%      |                                                    |
|TERMINAL (d)           | 16/17 (94%)   9/10 (90%)  15/16 (94%)  17/17 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   413          469          525          567       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.178N     P=0.325      P=0.404N     P=0.296N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.564      P=0.224N     P=0.307N     P=0.389N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.462N     P=0.191N     P=0.273N     P=0.336N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.358                                           |                                                    |
|FISHER EXACT           |               P=0.093N     P=0.322N     P=0.500N   |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   8/50 (16%)   3/50 (6%)  |  3/49 (6%)    8/49 (16%)   6/50 (12%)   3/50 (6%)  |
|ADJUSTED (b)           |  11.5%        33.4%        26.8%        13.3%      |   9.6%        31.3%        22.4%         9.4%      |
|TERMINAL (d)           |  1/17 (6%)    2/10 (20%)   2/16 (13%)   1/17 (6%)  |  1/28 (4%)    7/24 (29%)   4/24 (17%)   1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   586          629          454          602       |   716          674          706          555       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.263N     P=0.188      P=0.121      P=0.613N   |  P=0.361N     P=0.059      P=0.183      P=0.571    |
|INCIDENTAL TUMOR       |  P=0.422N     P=0.300      P=0.099      P=0.581    |  P=0.339N     P=0.059      P=0.216      P=0.658    |
|LOGISTIC REGRESSION    |  P=0.367N     P=0.275      P=0.101      P=0.651N   |  P=0.339N     P=0.056      P=0.179      P=0.663N   |
|COCHRAN-ARMITAGE       |  P=0.402N                                          |  P=0.252N                                          |
|FISHER EXACT           |               P=0.357      P=0.100      P=0.661N   |               P=0.100      P=0.254      P=0.651N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  21
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    0/50 (0%)    1/50 (2%)    3/50 (6%)  |  3/49 (6%)    1/49 (2%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |  22.2%         0.0%         4.5%        15.2%      |  10.7%         4.2%         4.2%         8.7%      |
|TERMINAL (d)           |  3/17 (18%)   0/10 (0%)    0/16 (0%)    2/17 (12%) |  3/28 (11%)   1/24 (4%)    1/24 (4%)    2/23 (9%)  |
|FIRST INCIDENCE (DAYS) |   729          ---          693          693       |   735 (T)      735 (T)      735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.546      P=0.146N     P=0.196N     P=0.487N   |  P=0.602      P=0.360N     P=0.360N     P=0.591N   |
|INCIDENTAL TUMOR       |  P=0.596      P=0.111N     P=0.169N     P=0.408N   |  P=0.602      P=0.360N     P=0.360N     P=0.591N   |
|LOGISTIC REGRESSION    |  P=0.566      P=0.122N     P=0.178N     P=0.439N   |  P=0.602      P=0.360N     P=0.360N     P=0.591N   |
|COCHRAN-ARMITAGE       |  P=0.445                                           |  P=0.608N                                          |
|FISHER EXACT           |               P=0.059N     P=0.181N     P=0.500N   |               P=0.309N     P=0.301N     P=0.490N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)   5/50 (10%)   9/50 (18%)   6/50 (12%) |  6/49 (12%)   9/49 (18%)   7/50 (14%)   5/50 (10%) |
|ADJUSTED (b)           |  32.1%        33.4%        30.1%        27.0%      |  19.7%        35.4%        26.3%        17.7%      |
|TERMINAL (d)           |  4/17 (24%)   2/10 (20%)   2/16 (13%)   3/17 (18%) |  4/28 (14%)   8/24 (33%)   5/24 (21%)   3/23 (13%) |
|FIRST INCIDENCE (DAYS) |   586          629          454          602       |   716          674          706          555       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.332N     P=0.569      P=0.401      P=0.455N   |  P=0.395N     P=0.180      P=0.389      P=0.617    |
|INCIDENTAL TUMOR       |  P=0.449N     P=0.513N     P=0.395      P=0.494N   |  P=0.376N     P=0.182      P=0.434      P=0.573N   |
|LOGISTIC REGRESSION    |  P=0.415N     P=0.533N     P=0.395      P=0.412N   |  P=0.399N     P=0.171      P=0.392      P=0.576N   |
|COCHRAN-ARMITAGE       |  P=0.521N                                          |  P=0.266N                                          |
|FISHER EXACT           |               P=0.380N     P=0.393      P=0.500N   |               P=0.288      P=0.516      P=0.486N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  22
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)  |  0/49 (0%)    1/49 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%        12.5%        10.2%      |   0.0%         4.2%         0.0%         4.3%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    2/16 (13%)   1/17 (6%)  |  0/28 (0%)    1/24 (4%)    0/24 (0%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          735 (T)      715       |   ---          735 (T)      ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.184        (e)        P=0.223      P=0.250    |  P=0.433      P=0.469        (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.205        (e)        P=0.223      P=0.304    |  P=0.433      P=0.469        (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.191        (e)        P=0.223      P=0.263    |  P=0.433      P=0.469        (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.136                                           |  P=0.468                                           |
|FISHER EXACT           |                 (e)        P=0.247      P=0.247    |               P=0.500        (e)        P=0.505    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)  |  1/49 (2%)    2/49 (4%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.9%         5.3%        12.5%        15.8%      |   3.6%         8.0%         0.0%         4.3%      |
|TERMINAL (d)           |  1/17 (6%)    0/10 (0%)    2/16 (13%)   2/17 (12%) |  1/28 (4%)    1/24 (4%)    0/24 (0%)    1/23 (4%)  |
|FIRST INCIDENCE (DAYS) |   735 (T)      675          735 (T)      715       |   735 (T)      727          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.265      P=0.674      P=0.478      P=0.313    |  P=0.621N     P=0.443      P=0.531N     P=0.718    |
|INCIDENTAL TUMOR       |  P=0.296      P=0.724      P=0.478      P=0.357    |  P=0.632N     P=0.446      P=0.531N     P=0.718    |
|LOGISTIC REGRESSION    |  P=0.280      P=0.709      P=0.478      P=0.334    |  P=0.634N     P=0.439      P=0.531N     P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.188                                           |  P=0.571N                                          |
|FISHER EXACT           |               P=0.753N     P=0.500      P=0.309    |               P=0.500      P=0.495N     P=0.747N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  23
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  6/50 (12%)   8/50 (16%)   8/50 (16%)   8/50 (16%) |
|ADJUSTED (b)           |                                                    |  16.9%        27.9%        27.6%        28.1%      |
|TERMINAL (d)           |                                                    |  2/28 (7%)    5/24 (21%)   5/24 (21%)   5/23 (22%) |
|FIRST INCIDENCE (DAYS) |                                                    |   638          663          326          560       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.299      P=0.274      P=0.294      P=0.250    |
|INCIDENTAL TUMOR       |                                                    |  P=0.324      P=0.337      P=0.375      P=0.443    |
|LOGISTIC REGRESSION    |                                                    |  P=0.395      P=0.345      P=0.381      P=0.354    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.430                                           |
|FISHER EXACT           |                                                    |               P=0.387      P=0.387      P=0.387    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%         3.7%         5.6%      |
|TERMINAL (d)           |                                                    |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          729          619       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.070        (e)        P=0.486      P=0.199    |
|INCIDENTAL TUMOR       |                                                    |  P=0.170        (e)        P=0.514      P=0.593    |
|LOGISTIC REGRESSION    |                                                    |  P=0.092        (e)        P=0.474      P=0.227    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.090                                           |
|FISHER EXACT           |                                                    |                 (e)        P=0.500      P=0.247    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  24
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  6/50 (12%)   8/50 (16%)   8/50 (16%)  10/50 (20%) |
|ADJUSTED (b)           |                                                    |  16.9%        27.9%        27.6%        32.1%      |
|TERMINAL (d)           |                                                    |  2/28 (7%)    5/24 (21%)   5/24 (21%)   5/23 (22%) |
|FIRST INCIDENCE (DAYS) |                                                    |   638          663          326          560       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.123      P=0.274      P=0.294      P=0.116    |
|INCIDENTAL TUMOR       |                                                    |  P=0.170      P=0.337      P=0.375      P=0.360    |
|LOGISTIC REGRESSION    |                                                    |  P=0.189      P=0.345      P=0.381      P=0.197    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.208                                           |
|FISHER EXACT           |                                                    |               P=0.387      P=0.387      P=0.207    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.7%         0.0%         6.3%         0.0%      |   2.0%         2.2%         5.6%         0.0%      |
|TERMINAL (d)           |  0/17 (0%)    0/10 (0%)    1/16 (6%)    0/17 (0%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   520          ---          735 (T)      ---       |   433          583          583          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.241N     P=0.274N     P=0.503N     P=0.212N   |  P=0.356N     P=0.756N     P=0.476      P=0.496N   |
|INCIDENTAL TUMOR       |  P=0.278N     P=0.198N     P=0.521N     P=0.261N   |  P=0.228N     P=0.672N     P=0.591      P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.277N     P=0.207N     P=0.500N     P=0.225N   |  P=0.361N     P=0.677      P=0.465      P=0.658N   |
|COCHRAN-ARMITAGE       |  P=0.276N                                          |  P=0.325N                                          |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.247N   |               P=0.753N     P=0.500      P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  25
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 35/50 (70%)  31/50 (62%)  28/50 (56%)  32/50 (64%) | 18/50 (36%)  19/50 (38%)  13/50 (26%)  20/50 (40%) |
|ADJUSTED (b)           |  86.0%        85.5%        77.2%        82.1%      |  45.8%        48.8%        39.5%        50.7%      |
|TERMINAL (d)           | 12/17 (71%)   6/10 (60%)   9/16 (56%)  11/17 (65%) |  7/28 (25%)   6/24 (25%)   6/24 (25%)   6/23 (26%) |
|FIRST INCIDENCE (DAYS) |   413          408          525          334       |   674          525          650          534       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.126N     P=0.289      P=0.198N     P=0.231N   |  P=0.193      P=0.311      P=0.377N     P=0.208    |
|INCIDENTAL TUMOR       |  P=0.479N     P=0.319N     P=0.104N     P=0.358N   |  P=0.311      P=0.530      P=0.190N     P=0.378    |
|LOGISTIC REGRESSION    |  P=0.412N     P=0.303N     P=0.105N     P=0.324N   |  P=0.465      P=0.489N     P=0.237N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.463N                                          |  P=0.359                                           |
|FISHER EXACT           |               P=0.263N     P=0.107N     P=0.335N   |               P=0.500      P=0.194N     P=0.418    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.6%        11.0%         0.0%         3.8%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/17 (6%)    0/10 (0%)    0/16 (0%)    0/17 (0%)  |  0/28 (0%)    0/24 (0%)    0/24 (0%)    0/23 (0%)  |
|FIRST INCIDENCE (DAYS) |   436          469          ---          693       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.137N     P=0.422      P=0.121N     P=0.281N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.243N     P=0.546      P=0.145N     P=0.384N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.161N     P=0.600      P=0.115N     P=0.304N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.166N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.121N     P=0.309N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  26
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 48/50 (96%)  49/50 (98%)  46/50 (92%) | 45/50 (90%)  49/50 (98%)  49/50 (98%)  47/50 (94%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  97.8%       100.0%        98.0%        95.9%      |
|TERMINAL (d)           | 17/17 (100%) 10/10 (100%) 16/16 (100%) 17/17 (100%)| 27/28 (96%)  24/24 (100%) 23/24 (96%)  21/23 (91%) |
|FIRST INCIDENCE (DAYS) |   413          274          454          497       |   534          485          326          527       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039N*    P=0.107      P=0.509N     P=0.172N   |  P=0.159      P=0.076      P=0.092      P=0.076    |
|INCIDENTAL TUMOR       |  P=0.023N*    P=0.280N       (e)        P=0.055N   |  P=0.621      P=0.139      P=0.081      P=0.552    |
|LOGISTIC REGRESSION    |  P=0.066N     P=0.339N       (e)        P=0.055N   |  P=0.603N     P=0.159      P=0.086      P=0.392    |
|COCHRAN-ARMITAGE       |  P=0.047N*                                         |  P=0.582                                           |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.059N   |               P=0.102      P=0.102      P=0.357    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/50 (80%)  38/50 (76%)  34/50 (68%)  40/50 (80%) | 28/50 (56%)  23/50 (46%)  23/50 (46%)  30/50 (60%) |
|ADJUSTED (b)           |  92.4%        94.2%        88.1%        97.3%      |  64.9%        58.9%        62.8%        73.5%      |
|TERMINAL (d)           | 14/17 (82%)   8/10 (80%)  12/16 (75%)  16/17 (94%) | 13/28 (46%)   9/24 (38%)  11/24 (46%)  13/23 (57%) |
|FIRST INCIDENCE (DAYS) |   413          408          213          334       |   433          525          583          534       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.172N     P=0.155      P=0.254N     P=0.360N   |  P=0.082      P=0.484N     P=0.468N     P=0.160    |
|INCIDENTAL TUMOR       |  P=0.487      P=0.516N     P=0.095N     P=0.592    |  P=0.139      P=0.250N     P=0.214N     P=0.341    |
|LOGISTIC REGRESSION    |  P=0.476      P=0.488N     P=0.126N     P=0.591N   |  P=0.158      P=0.216N     P=0.246N     P=0.398    |
|COCHRAN-ARMITAGE       |  P=0.424                                           |  P=0.187                                           |
|FISHER EXACT           |               P=0.405N     P=0.127N     P=0.598N   |               P=0.212N     P=0.212N     P=0.420    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05158 TEST: 03                                                 PAGE  27
                         STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 7-5MOLYBDENUM TRIOXIDE

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      10 MG/M3     30 MG/M3     100       |   CONTROL      10 MG/M3     30 MG/M3     100       |
|                       |                                          MG/M3     |                                          MG/M3     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 50/50 (100%) 50/50 (100%) 49/50 (98%) | 48/50 (96%)  50/50 (100%) 49/50 (98%)  49/50 (98%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      | 100.0%       100.0%        98.0%        98.0%      |
|TERMINAL (d)           | 17/17 (100%) 10/10 (100%) 16/16 (100%) 17/17 (100%)| 28/28 (100%) 24/24 (100%) 23/24 (96%)  22/23 (96%) |
|FIRST INCIDENCE (DAYS) |   413          274          213          334       |   433          485          326          527       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.077N     P=0.071      P=0.540      P=0.295N   |  P=0.160      P=0.133      P=0.188      P=0.098    |
|INCIDENTAL TUMOR       |  P=0.451N       (e)          (e)          (e)      |  P=0.627N     P=0.557      P=0.492      P=0.739N   |
|LOGISTIC REGRESSION    |  P=0.451N       (e)          (e)          (e)      |  P=0.650N     P=0.600      P=0.614      P=0.709    |
|COCHRAN-ARMITAGE       |  P=0.221N                                          |  P=0.627                                           |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=0.500N   |               P=0.247      P=0.500      P=0.500    |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).