TDMS Study 05158-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MOLYBDENUM TRIOXIDE DATE: 04/04/96
EXPERIMENT: 05158 TEST: 03 TIME: 02:10:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95240 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61369C
PATHOLOGIST: GRUMBEIN, S. CAS: 0001313-27-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MOLYBDENUM TRIOXIDE DATE: 04/04/96
EXPERIMENT: 05158 TEST: 03 TIME: 02:10:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95240 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61369C
PATHOLOGIST: GRUMBEIN, S. CAS: 0001313-27-5
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 413 425 436 487 495 520 520 546 549 553 |
| 559 568 581 581 586 606 609 617 626 629 |
| 631 643 653 655 665 674 678 688 693 712 |
| 715 721 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 274 408 436 469 473 485 501 509 520 520 |
| 534 553 553 553 553 569 571 574 581 581 |
| 590 607 610 617 622 629 634 649 653 660 |
| 665 675 684 688 692 693 716 716 727 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 213 454 459 477 503 525 526 553 553 566 |
| 566 585 594 611 623 627 629 630 632 637 |
| 637 653 653 665 665 671 676 677 693 693 |
| 706 721 727 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 15 334 396 406 497 551 567 581 598 602 |
| 618 621 635 645 660 662 662 665 673 674 |
| 679 679 681 692 693 693 696 706 715 717 |
| 721 721 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 96.0 94.0 86.0 70.0 50.0 34.0 |
| | |
| | |
|10 MG/M3 | 100.0 100.0 100.0 98.0 96.0 88.0 78.0 58.0 38.0 20.0 |
| | |
| | |
|30 MG/M3 | 100.0 100.0 98.0 98.0 98.0 92.0 86.0 74.0 50.0 32.0 |
| | |
| | |
|100 | 98.0 98.0 98.0 96.0 92.0 92.0 90.0 80.0 64.0 34.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 MG/M3 30 MG/M3 100 |
| MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 34.0% 20.0% 32.0% 34.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.198N P=0.142 P=1.000 P=0.681N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.9 586.9 603.8 611.7 |
|NATURAL DEATHS (C) | (15.1) (15.4) (17.6) (25.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.2 616.5 645.8 653.6 |
|(STANDARD ERROR) | (13.5) (14.9) (14.8) (18.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 106 433 464 516 534 559 598 638 674 679 |
| 679 680 688 693 706 707 715 716 716 716 |
| 727 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 485 516 525 573 581 583 599 600 608 609 |
| 618 629 637 640 660 663 671 674 681 692 |
| 693 706 721 721 721 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 326 464 531 534 541 541 560 583 583 604 |
| 615 650 653 653 665 686 686 688 692 693 |
| 706 706 721 729 729 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 527 534 538 538 555 560 569 580 580 581 |
| 583 615 618 619 622 636 637 646 652 660 |
| 667 673 688 698 720 721 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 98.0 94.0 90.0 86.0 84.0 56.0 |
| | |
| | |
|10 MG/M3 | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 84.0 68.0 48.0 |
| | |
| | |
|30 MG/M3 | 100.0 100.0 100.0 98.0 98.0 96.0 88.0 80.0 70.0 48.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 78.0 60.0 46.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 MG/M3 30 MG/M3 100 |
| MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 48.0% 48.0% 46.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.328 P=0.426 P=0.459 P=0.253 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 621.5 635.9 625.7 620.1 |
|NATURAL DEATHS (C) | (31.0) (13.1) (19.0) (11.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 685.1 683.5 678.2 673.0 |
|(STANDARD ERROR) | (15.7) ( 9.8) (12.5) (10.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MOLYBDENUM TRIOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 MG/M3 = 2
30 MG/M3 = 3
100 MG/M3 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 2 1
| 4 3 2 4 1 1 3
| 4 442 1 1 332 31
| 4 223113
90 + 2 213 1 4
| 2 2 33 4 4
| 22 13 11 4 4 4
| 3 3
P 80 + 2 2 11 4 4
E | 2 2131 3
R | 113 3 34 4 4
C | 11 33 4 4
E 70 + 2 2 1 1 33
N |
T | 22 1 113 4 4
|
S 60 + 2 2 11
U | 2 2 11 3
R | 222 1 1 3 444
V | 1 1
I 50 + 22 131
V | 22 33 44
A | 2 22 1 144 4
L | 2 2 1 1
40 + 3 311
| 2 2 3 3
| 222 13 1
| 3
30 +
| 2 2
| 22
| 2 2
20 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 38 obs hidden.
MOLYBDENUM TRIOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 MG/M3 = 2
30 MG/M3 = 3
100 MG/M3 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 1 3 2 4
| 1 3 1 3 2 2 44
96 + 1 1 2 23
| 1 1 233 2
| 1 13 4 22
| 1 1 22
P 88 + 3 1 4 2 1
E | 3 443 1 1
R | 22 1 1
C | 3 3
E 80 + 44 232
N | 4 322 3 11
T | 4422 33 11
| 22
S 72 + 2 3 2 1 1
U | 4 4 3 3
R | 22 1 1
V | 4 4 2233
I 64 + 44 22
V | 4 4 22
A | 44 3 3 11
L | 44 2 2 1 1
56 + 4 4 2 2 1
| 44 3 3
| 4 4
| 22
48 + 42 2
| 4 4
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.