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TDMS Study 05158-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 03                                                                                     TIME: 02:10:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0001313-27-5    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96      
EXPERIMENT: 05158 TEST: 03                                                                                     TIME: 02:10:42      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C      
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0001313-27-5   
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      413   425   436   487   495   520   520   546   549   553                 |
 |      559   568   581   581   586   606   609   617   626   629                 |
 |      631   643   653   655   665   674   678   688   693   712                 |
 |      715   721   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 10        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      274   408   436   469   473   485   501   509   520   520                 |
 |      534   553   553   553   553   569   571   574   581   581                 |
 |      590   607   610   617   622   629   634   649   653   660                 |
 |      665   675   684   688   692   693   716   716   727   730                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 30 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      213   454   459   477   503   525   526   553   553   566                 |
 |      566   585   594   611   623   627   629   630   632   637                 |
 |      637   653   653   665   665   671   676   677   693   693                 |
 |      706   721   727   729                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 100     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      15    334   396   406   497   551   567   581   598   602                 |
 |      618   621   635   645   660   662   662   665   673   674                 |
 |      679   679   681   692   693   693   696   706   715   717                 |
 |      721   721   732                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  96.0  94.0  86.0  70.0  50.0  34.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/M3   |   100.0 100.0 100.0  98.0  96.0  88.0  78.0  58.0  38.0  20.0      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/M3   |   100.0 100.0  98.0  98.0  98.0  92.0  86.0  74.0  50.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 |100        |    98.0  98.0  98.0  96.0  92.0  92.0  90.0  80.0  64.0  34.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      10 MG/M3     30 MG/M3     100      |
 |                                                                       MG/M3    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       34.0%        20.0%        32.0%        34.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.198N     P=0.142      P=1.000      P=0.681N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       598.9        586.9        603.8        611.7    |
 |NATURAL DEATHS (C)      |       (15.1)       (15.4)       (17.6)       (25.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       645.2        616.5        645.8        653.6    |
 |(STANDARD ERROR)        |       (13.5)       (14.9)       (14.8)       (18.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      106   433   464   516   534   559   598   638   674   679                 |
 |      679   680   688   693   706   707   715   716   716   716                 |
 |      727   730                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      485   516   525   573   581   583   599   600   608   609                 |
 |      618   629   637   640   660   663   671   674   681   692                 |
 |      693   706   721   721   721   727                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 30 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      326   464   531   534   541   541   560   583   583   604                 |
 |      615   650   653   653   665   686   686   688   692   693                 |
 |      706   706   721   729   729   730                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 100     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      527   534   538   538   555   560   569   580   580   581                 |
 |      583   615   618   619   622   636   637   646   652   660                 |
 |      667   673   688   698   720   721   727                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.0  98.0  98.0  98.0  94.0  90.0  86.0  84.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/M3   |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  84.0  68.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/M3   |   100.0 100.0 100.0  98.0  98.0  96.0  88.0  80.0  70.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0 100.0 100.0 100.0 100.0  92.0  78.0  60.0  46.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      10 MG/M3     30 MG/M3     100      |
 |                                                                       MG/M3    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.0%        48.0%        48.0%        46.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.328      P=0.426      P=0.459      P=0.253  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       621.5        635.9        625.7        620.1    |
 |NATURAL DEATHS (C)      |       (31.0)       (13.1)       (19.0)       (11.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       685.1        683.5        678.2        673.0    |
 |(STANDARD ERROR)        |       (15.7)       ( 9.8)       (12.5)       (10.3)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        MOLYBDENUM TRIOXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        10 MG/M3         = 2
                                                        30 MG/M3         = 3
                                                        100     MG/M3    = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1  4                              3         2                    1
      |    4                              3         2        4           1 1    3
      |                                                      4         442 1 1  332 31
      |                                                                 4         223113
   90 +                                                                            2 213   1   4
      |                                                                              2 2   33  4 4
      |                                                                                22  13 11 4 4   4
      |                                                                                        3 3
P  80 +                                                                                    2 2 11      4  4
E     |                                                                                      2 2131 3
R     |                                                                                           113 3  34 4 4
C     |                                                                                            11    33   4  4
E  70 +                                                                                        2  2 1   1 33
N     |
T     |                                                                                           22    1 113    4 4
      |
S  60 +                                                                                            2  2    11
U     |                                                                                               2 2   11 3
R     |                                                                                                 222  1 1 3 444
V     |                                                                                                        1 1
I  50 +                                                                                                   22     131
V     |                                                                                                    22     33 44
A     |                                                                                                     2 22   1 144 4
L     |                                                                                                        2 2   1  1
   40 +                                                                                                              3 311
      |                                                                                                          2 2   3 3
      |                                                                                                            222   13 1
      |                                                                                                                     3
   30 +
      |                                                                                                              2   2
      |                                                                                                                  22
      |                                                                                                                   2 2
   20 +                                                                                                                     2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 38 obs hidden.
                                                        MOLYBDENUM TRIOXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        10 MG/M3         = 2
                                                        30 MG/M3         = 3
                                                        100     MG/M3    = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                 1                                 3                        2      4
      |                   1                                 3               1     3  2   2  44
   96 +                                                                     1     1      2 23
      |                                                                           1      1 233    2
      |                                                                                  1   13 4 22
      |                                                                                      1  1  22
P  88 +                                                                                       3 1 4 2  1
E     |                                                                                         3 443  1     1
R     |                                                                                                22    1     1
C     |                                                                                             3   3
E  80 +                                                                                            44   232
N     |                                                                                             4    322  3    11
T     |                                                                                                  4422 33    11
      |                                                                                                     22
S  72 +                                                                                                      2 3 2   1 1
U     |                                                                                                   4 4    3  3
R     |                                                                                                          22    1 1
V     |                                                                                                     4 4   2233
I  64 +                                                                                                       44   22
V     |                                                                                                        4 4  22
A     |                                                                                                          44  3 3 11
L     |                                                                                                           44 2 2  1 1
   56 +                                                                                                            4 4 2 2  1
      |                                                                                                              44  3  3
      |                                                                                                               4  4
      |                                                                                                                  22
   48 +                                                                                                                  42 2
      |                                                                                                                   4 4
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.