Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2580

TDMS Study 05160-05 Pathology Tables

NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97
Route: DOSED WATER                                                                                                Time: 08:29:54

                                                         2 YEAR CHRONIC




       Facility:  TSI Mason Research

       Chemical CAS #:  127-00-4

       Lock Date:  05/25/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            7            7            5                                     
    Natural Death                                     13           10           13           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           33           30           31                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (49)         (49)         (48)                                   
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Parasite Metazoan                                3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
   Intestine Large, Rectum                            (49)         (49)         (48)         (49)                                   
      Parasite Metazoan                                6 (12%)      4 (8%)       3 (6%)       7 (14%)                               
   Intestine Large, Cecum                             (47)         (49)         (48)         (48)                                   
      Dilatation                                                    1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                                                       1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (44)         (44)         (43)         (46)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Intestine Small, Ileum                             (42)         (45)         (43)         (45)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       5 (10%)      3 (6%)       7 (14%)                               
      Basophilic Focus                                29 (58%)     33 (66%)     27 (54%)     32 (64%)                               
      Clear Cell Focus                                 3 (6%)       7 (14%)      7 (14%)      2 (4%)                                
      Congestion                                                    2 (4%)                                                          
      Deformity                                        3 (6%)       6 (12%)      3 (6%)                                             
      Eosinophilic Focus                               6 (12%)      3 (6%)       7 (14%)      4 (8%)                                
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                       2 (4%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (4%)       3 (6%)      12 (24%)      4 (8%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                     12 (24%)      5 (10%)      9 (18%)     11 (22%)                               
      Mixed Cell Focus                                 4 (8%)       8 (16%)      5 (10%)      6 (12%)                               
      Necrosis                                         3 (6%)       2 (4%)       5 (10%)      1 (2%)                                
      Pigmentation, Bile                               1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
      Artery, Thrombosis                               1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Kupffer Cell, Pigmentation                                    1 (2%)                                                          
   Mesentery                                          (9)          (11)         (12)         (10)                                   
      Hemorrhage                                       1 (11%)                                                                      
      Fat, Necrosis                                    8 (89%)     10 (91%)     11 (92%)      9 (90%)                               
   Pancreas                                           (47)         (49)         (49)         (48)                                   
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Acinus, Atrophy                                 12 (26%)      4 (8%)       3 (6%)       5 (10%)                               
      Acinus, Hyperplasia                                           1 (2%)       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     5 (10%)      1 (2%)                    3 (6%)                                
      Ulcer                                            2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
      Epithelium, Hyperplasia                          4 (8%)       3 (6%)       3 (6%)       3 (6%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                        12 (24%)      6 (12%)      7 (14%)      7 (14%)                               
      Ulcer                                                                      2 (4%)                                             
   Tooth                                                           (1)                                                              
      Developmental Malformation                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  18 (36%)     21 (42%)     15 (30%)     11 (22%)                               
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Atrium, Inflammation, Chronic Active                          1 (2%)                                                          
      Atrium, Thrombosis                               4 (8%)       2 (4%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Angiectasis                                      7 (14%)      8 (16%)      9 (18%)     10 (20%)                               
      Cytoplasmic Alteration                           5 (10%)      3 (6%)       1 (2%)       4 (8%)                                
      Degeneration, Cystic                                          1 (2%)       1 (2%)                                             
      Hemorrhage                                       2 (4%)       3 (6%)                                                          
      Vacuolization Cytoplasmic                        4 (8%)       5 (10%)      7 (14%)      8 (16%)                               
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      5 (10%)                   1 (2%)       2 (4%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (46)         (49)         (48)         (48)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Metaplasia                                       1 (2%)                                                                       
   Parathyroid Gland                                  (50)         (50)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Necrosis                                                                                1 (2%)                                
      Pars Distalis, Angiectasis                       1 (2%)                    4 (8%)       1 (2%)                                
      Pars Distalis, Cyst                             13 (27%)     11 (22%)     11 (22%)     13 (26%)                               
      Pars Distalis, Hemorrhage                        2 (4%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                       4 (8%)       6 (12%)      6 (12%)                                            
      Pars Distalis, Pigmentation                                                             1 (2%)                                
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      C-Cell, Hyperplasia                             10 (20%)     11 (22%)      6 (12%)      8 (16%)                               
      Follicle, Cyst                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (49)         (49)         (49)                                   
      Atrophy                                                                                 2 (4%)                                
      Cyst                                             4 (8%)       4 (8%)       4 (8%)       6 (12%)                               
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)                                             
      Bilateral, Cyst                                                            1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             6 (12%)      4 (8%)      10 (20%)      8 (16%)                               
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
      Bilateral, Cyst                                  1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                                                          1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Abscess                                                                    1 (2%)                                             
      Cyst                                                          1 (2%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                       4 (8%)                    3 (6%)       4 (8%)                                
      Hyperplasia, Cystic                              1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       3 (6%)                                             
      Bilateral, Hydrometra                                                                   1 (2%)                                
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Vagina                                                          (2)                                                              
      Hemorrhage                                                    1 (50%)                                                         
      Infiltration Cellular, Polymorphonuclear                      1 (50%)                                                         
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Pigmentation                                                  1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (50)         (47)         (49)                                   
      Atrophy                                                                                 2 (4%)                                
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      1 (2%)       3 (6%)                    1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                        3 (6%)                                                                       
   Lymph Node                                         (11)         (9)          (15)         (7)                                    
      Hemorrhage                                       1 (9%)       2 (22%)      1 (7%)                                             
      Hyperplasia, Lymphoid                                                      1 (7%)                                             
      Pigmentation                                                               1 (7%)                                             
      Deep Cervical, Hemorrhage                        1 (9%)                    1 (7%)                                             
      Deep Cervical, Hyperplasia, Plasma Cell                                    1 (7%)                                             
      Deep Cervical, Pigmentation                                                1 (7%)                                             
      Iliac, Amyloid Deposition                                     1 (11%)                                                         
      Iliac, Hemorrhage                                2 (18%)      1 (11%)                                                         
      Iliac, Pigmentation                                           1 (11%)                                                         
      Mediastinal, Hemorrhage                          4 (36%)      2 (22%)      7 (47%)      1 (14%)                               
      Mediastinal, Hyperplasia, Lymphoid                                         1 (7%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (7%)                                             
      Mediastinal, Inflammation, Acute                              1 (11%)                                                         
      Mediastinal, Pigmentation                        2 (18%)                   5 (33%)                                            
      Pancreatic, Hemorrhage                           2 (18%)                   2 (13%)      1 (14%)                               
      Pancreatic, Hyperplasia, Histiocytic             1 (9%)                    1 (7%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                          1 (7%)                                             
      Renal, Hemorrhage                                3 (27%)      2 (22%)      4 (27%)      1 (14%)                               
      Renal, Hyperplasia, Histiocytic                  1 (9%)                                                                       
      Renal, Pigmentation                              1 (9%)       2 (22%)      1 (7%)       1 (14%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Atrophy                                          1 (2%)                                                                       
      Ectasia                                          1 (2%)                    1 (2%)                                             
      Hemorrhage                                       6 (12%)      4 (8%)       4 (8%)       2 (4%)                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Plasma Cell                         1 (2%)                    4 (8%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Pigmentation                                     1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Atrophy                                          2 (4%)                                                                       
      Hemorrhage                                       7 (14%)      3 (6%)       6 (12%)      5 (10%)                               
      Hyperplasia, Histiocytic                                      3 (6%)       4 (8%)       2 (4%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Pigmentation                                                  1 (2%)       1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Accessory Spleen                                                           1 (2%)                                             
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Fibrosis                                         3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 7 (14%)      2 (4%)       3 (6%)       1 (2%)                                
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
      Pigmentation                                     7 (14%)     11 (22%)      8 (16%)     10 (20%)                               
      Capsule, Cyst                                                                           1 (2%)                                
      Capsule, Fibrosis                                                                       2 (4%)                                
   Thymus                                             (48)         (49)         (50)         (50)                                   
      Atrophy                                         16 (33%)     10 (20%)     17 (34%)     14 (28%)                               
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Epithelial Cell, Hyperplasia                     7 (15%)      6 (12%)      9 (18%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Dilatation                                      34 (68%)     33 (66%)     25 (51%)     27 (54%)                               
      Hyperplasia                                     20 (40%)     23 (46%)     14 (29%)     19 (38%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Exudate                                                       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     6 (12%)      7 (14%)      7 (14%)      4 (8%)                                
      Malformation                                                               1 (2%)                                             
      Femur, Callus                                    1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Femur, Hyperostosis                              2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       2 (4%)       2 (4%)       3 (6%)       2 (4%)                                
   Spinal Cord                                        (2)          (1)                                                              
      Hemorrhage                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                                                          
      Hemorrhage                                       1 (2%)                    2 (4%)       2 (4%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)       2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                    3 (6%)       2 (4%)                                
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)                                                          
      Mediastinum, Necrosis                                                                   1 (2%)                                
   Nose                                               (50)         (48)         (49)         (49)                                   
      Foreign Body                                                               1 (2%)                                             
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Olfactory Epithelium, Degeneration, Hyaline      2 (4%)       9 (19%)      4 (8%)       3 (6%)                                
      Olfactory Epithelium, Inflammation, Chronic                                                                                   
          Active                                       2 (4%)       2 (4%)                                                          
      Respiratory Epithelium, Degeneration, Hyaline    6 (12%)      3 (6%)       8 (16%)     12 (24%)                               
      Respiratory Epithelium, Hyperplasia              1 (2%)      10 (21%)      1 (2%)       5 (10%)                               
      Respiratory Epithelium, Inflammation,                                                                                         
          Chronic Active                              13 (26%)      9 (19%)     18 (37%)      6 (12%)                               
      Respiratory Epithelium, Thrombosis                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (2)                                    
      External Ear, Hyperplasia                                                               1 (50%)                               
   Zymbal's Gland                                                  (1)          (1)                                                 
      Hyperplasia                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (46)         (49)         (50)         (50)                                   
      Casts                                                                      1 (2%)                                             
      Cyst                                             1 (2%)                                 2 (4%)                                
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Mineralization                                  24 (52%)     28 (57%)     26 (52%)     30 (60%)                               
      Nephropathy                                     23 (50%)     23 (47%)     15 (30%)     20 (40%)                               
      Pelvis, Mineralization                           1 (2%)                                                                       
      Renal Tubule, Degeneration, Hyaline              1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                       2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (49)                                   
      Dilatation                                                    1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     18           14           19           17                                     
    Moribund Sacrifice                                12           13            7           10                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                19           23           24           23                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (46)         (46)         (48)         (47)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Parasite Metazoan                                1 (2%)       3 (7%)       1 (2%)       2 (4%)                                
   Intestine Large, Rectum                            (45)         (47)         (46)         (47)                                   
      Parasite Metazoan                                3 (7%)       3 (6%)       3 (7%)       2 (4%)                                
   Intestine Large, Cecum                             (45)         (46)         (45)         (44)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (39)         (42)         (41)         (42)                                   
      Fibrosis                                                                                1 (2%)                                
   Intestine Small, Ileum                             (39)         (41)         (41)         (43)                                   
      Parasite Metazoan                                             1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      5 (10%)     11 (22%)      7 (14%)      9 (18%)                               
      Basophilic Focus                                 3 (6%)                                                                       
      Clear Cell Focus                                 7 (14%)      8 (16%)      7 (14%)      3 (6%)                                
      Congestion                                       2 (4%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Deformity                                        1 (2%)       2 (4%)       1 (2%)                                             
      Degeneration, Cystic                            12 (24%)      8 (16%)     12 (24%)     12 (24%)                               
      Eosinophilic Focus                               4 (8%)      10 (20%)     10 (20%)      3 (6%)                                
      Hemorrhage                                                    2 (4%)                                                          
      Hepatodiaphragmatic Nodule                       2 (4%)       3 (6%)       5 (10%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                 6 (12%)      6 (12%)      2 (4%)       5 (10%)                               
      Necrosis                                                                   1 (2%)       2 (4%)                                
      Vacuolization Cytoplasmic                        2 (4%)                    4 (8%)       1 (2%)                                
      Bile Duct, Hyperplasia                           1 (2%)       2 (4%)       3 (6%)                                             
      Centrilobular, Congestion                                     1 (2%)                                                          
      Centrilobular, Degeneration                      1 (2%)                    1 (2%)                                             
      Centrilobular, Vacuolization Cytoplasmic         1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Kupffer Cell, Pigmentation                       1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vein, Dilatation                                              1 (2%)                                                          
   Mesentery                                          (12)         (11)         (10)         (14)                                   
      Accessory Spleen                                                                        1 (7%)                                
      Inflammation, Chronic Active                                  1 (9%)                                                          
      Necrosis                                         1 (8%)                                                                       
      Pigmentation                                     1 (8%)                                                                       
      Fat, Necrosis                                    9 (75%)     10 (91%)      9 (90%)     12 (86%)                               
      Fat, Pigmentation                                                          1 (10%)                                            
   Oral Mucosa                                        (2)                                                                           
      Hyperplasia                                      1 (50%)                                                                      
   Pancreas                                           (48)         (45)         (46)         (48)                                   
      Acinus, Atrophy                                 10 (21%)      9 (20%)     13 (28%)     12 (25%)                               
      Acinus, Hyperplasia                                                        1 (2%)       3 (6%)                                
      Artery, Hyperplasia                              2 (4%)                                                                       
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (48)         (49)                                   
      Diverticulum                                                               1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       2 (4%)                                             
      Ulcer                                           10 (20%)     10 (20%)      8 (17%)     13 (27%)                               
      Epithelium, Hyperplasia                          3 (6%)       4 (8%)       2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (48)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Necrosis                                        17 (34%)     14 (29%)     13 (27%)     17 (34%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (48)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic Active                           1 (2%)                                                          
      Aorta, Mineralization                            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  35 (70%)     41 (82%)     42 (84%)     33 (66%)                               
      Fibrosis                                                                                1 (2%)                                
      Mineralization                                   2 (4%)                                 1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Atrium, Thrombosis                               3 (6%)                    6 (12%)      4 (8%)                                
      Ventricle, Pigmentation                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Cytoplasmic Alteration                                        2 (4%)       2 (4%)                                             
      Degeneration, Cystic                                                       1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                                                  3 (6%)                                             
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                     10 (20%)      8 (16%)      8 (16%)      4 (8%)                                
   Islets, Pancreatic                                 (49)         (45)         (46)         (47)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (48)         (49)         (50)         (47)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)                                             
   Pituitary Gland                                    (48)         (49)         (49)         (50)                                   
      Pars Distalis, Angiectasis                       3 (6%)       1 (2%)       3 (6%)       5 (10%)                               
      Pars Distalis, Cyst                              1 (2%)       3 (6%)       2 (4%)       2 (4%)                                
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                       8 (17%)      5 (10%)      5 (10%)      7 (14%)                               
      Pars Intermedia, Cyst                                         1 (2%)                    1 (2%)                                
      Pars Nervosa, Hemorrhage                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              4 (8%)       6 (12%)      5 (10%)      4 (8%)                                
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)                                    (1)                                    
      Necrosis                                         1 (33%)                                                                      
   Tissue NOS                                         (1)                                                                           
      Abdominal, Hemorrhage                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Penis                                              (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                             3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Fibrosis                                                                                1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     5 (10%)      1 (2%)       3 (6%)       5 (10%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                     4 (8%)       5 (10%)      7 (14%)      5 (10%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Testes                                             (50)         (49)         (50)         (50)                                   
      Atrophy                                          8 (16%)      9 (18%)     12 (24%)      8 (16%)                               
      Artery, Inflammation, Chronic Active                                       2 (4%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                   8 (16%)     11 (22%)     10 (20%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (45)         (47)         (49)                                   
      Atrophy                                          4 (9%)                    1 (2%)       3 (6%)                                
      Fibrosis                                                                   2 (4%)                                             
      Hyperplasia                                      2 (4%)       4 (9%)       2 (4%)       1 (2%)                                
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
   Lymph Node                                         (24)         (23)         (23)         (24)                                   
      Hemorrhage                                       1 (4%)       1 (4%)                    1 (4%)                                
      Iliac, Hemorrhage                                1 (4%)       1 (4%)                                                          
      Iliac, Hyperplasia, Lymphoid                                               1 (4%)                                             
      Iliac, Hyperplasia, Plasma Cell                               1 (4%)                                                          
      Mediastinal, Congestion                                                    1 (4%)                                             
      Mediastinal, Ectasia                                                       1 (4%)                                             
      Mediastinal, Hemorrhage                         11 (46%)     11 (48%)      8 (35%)     11 (46%)                               
      Mediastinal, Hyperplasia, Lymphoid               3 (13%)      2 (9%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell                         1 (4%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (4%)       1 (4%)                                             
      Mediastinal, Pigmentation                        3 (13%)      2 (9%)       1 (4%)                                             
      Pancreatic, Ectasia                                           1 (4%)                                                          
      Pancreatic, Hemorrhage                           1 (4%)       4 (17%)      2 (9%)       5 (21%)                               
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (4%)                                
      Renal, Ectasia                                                3 (13%)                                                         
      Renal, Hemorrhage                                3 (13%)      3 (13%)      1 (4%)       8 (33%)                               
      Renal, Hyperplasia, Lymphoid                                                            1 (4%)                                
      Renal, Hyperplasia, Plasma Cell                  1 (4%)                                                                       
      Renal, Pigmentation                              3 (13%)      4 (17%)      2 (9%)       7 (29%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Ectasia                                          1 (2%)       8 (16%)      2 (4%)       3 (6%)                                
      Hemorrhage                                       3 (6%)       1 (2%)       3 (6%)       2 (4%)                                
      Hyperplasia, Lymphoid                            5 (10%)      2 (4%)       3 (6%)       2 (4%)                                
      Hyperplasia, Plasma Cell                         2 (4%)       4 (8%)       5 (10%)      2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
      Ectasia                                          3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Hemorrhage                                       4 (8%)       4 (8%)       4 (8%)       6 (12%)                               
      Hyperplasia, Lymphoid                            4 (8%)       2 (4%)                    2 (4%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                                                                       
      Atrophy                                                       1 (2%)                                                          
      Congestion                                       3 (6%)                    2 (4%)                                             
      Cyst                                                                                    1 (2%)                                
      Fibrosis                                        10 (20%)     16 (32%)     19 (38%)     14 (28%)                               
      Hematopoietic Cell Proliferation                 3 (6%)       5 (10%)      2 (4%)       2 (4%)                                
      Necrosis                                         3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Pigmentation                                     2 (4%)                    2 (4%)       2 (4%)                                
      Capsule, Fibrosis                                2 (4%)       2 (4%)       2 (4%)                                             
      Capsule, Pigmentation                            1 (2%)                                 1 (2%)                                
   Thymus                                             (49)         (47)         (48)         (47)                                   
      Atrophy                                         30 (61%)     19 (40%)     18 (38%)     27 (57%)                               
      Hemorrhage                                       3 (6%)                    3 (6%)       2 (4%)                                
      Epithelial Cell, Hyperplasia                     5 (10%)      3 (6%)       2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (45)         (48)         (47)                                   
      Dilatation                                       8 (16%)     13 (29%)      9 (19%)      6 (13%)                               
      Hyperplasia                                      1 (2%)       3 (7%)       5 (10%)      6 (13%)                               
      Inflammation, Chronic Active                                                            2 (4%)                                
      Pigmentation                                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                   2 (4%)                                 1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       1 (2%)                                             
      Ulcer                                                                                   2 (4%)                                
      Epidermis, Hyperplasia                                        1 (2%)                                                          
      Hair Follicle, Atrophy                                                                  1 (2%)                                
      Subcutaneous Tissue, Fibrosis                                                           1 (2%)                                
      Subcutaneous Tissue, Foreign Body                                                       1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       4 (8%)                                
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Meninges, Angiectasis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)       1 (2%)       4 (8%)                                
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active                                               3 (6%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (8%)       1 (2%)       6 (12%)      1 (2%)                                
      Alveolus, Metaplasia, Squamous                                             1 (2%)                                             
   Nose                                               (50)         (47)         (49)         (50)                                   
      Foreign Body                                                  2 (4%)                    1 (2%)                                
      Nasopharyngeal Duct, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
      Olfactory Epithelium, Degeneration, Hyaline      1 (2%)                                 2 (4%)                                
      Olfactory Epithelium, Foreign Body               1 (2%)                                 1 (2%)                                
      Olfactory Epithelium, Hyperplasia                1 (2%)                                                                       
      Olfactory Epithelium, Inflammation, Chronic                                                                                   
          Active                                      10 (20%)      2 (4%)       6 (12%)      5 (10%)                               
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
      Respiratory Epithelium, Degeneration, Hyaline                 2 (4%)       1 (2%)                                             
      Respiratory Epithelium, Foreign Body             3 (6%)                                                                       
      Respiratory Epithelium, Hyperplasia             22 (44%)     20 (43%)     16 (33%)     28 (56%)                               
      Respiratory Epithelium, Inflammation                                       1 (2%)                                             
      Respiratory Epithelium, Inflammation, Chronic    1 (2%)                    1 (2%)       1 (2%)                                
      Respiratory Epithelium, Inflammation,                                                                                         
          Chronic Active                              22 (44%)     15 (32%)     22 (45%)     27 (54%)                               
      Respiratory Epithelium, Metaplasia                                                      1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     2 (4%)                                 1 (2%)                                
      Respiratory Epithelium, Thrombosis               4 (8%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (2)                                    
      Atrophy                                                                                 2 (100%)                              
      Hemorrhage                                                    1 (100%)                                                        
      Lens, Cataract                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                                                                 1 (2%)                                
      Cyst                                             3 (6%)                    2 (4%)       3 (6%)                                
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Mineralization                                   2 (4%)                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Nephropathy                                     46 (92%)     46 (94%)     46 (94%)     49 (98%)                               
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)                                             
      Renal Tubule, Pigmentation                       4 (8%)       3 (6%)       4 (8%)       3 (6%)                                
   Urinary Bladder                                    (48)         (50)         (49)         (49)                                   
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------