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TDMS Study 05160-05 Pathology Tables

NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97
Route: DOSED WATER                                                                                                Time: 08:29:54

                                                         2 YEAR CHRONIC




       Facility:  TSI Mason Research

       Chemical CAS #:  127-00-4

       Lock Date:  05/25/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            7            7            5                                     
    Natural Death                                     13           10           13           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           33           30           31                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (49)         (49)         (48)                                   
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Parasite Metazoan                                3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
   Intestine Large, Rectum                            (49)         (49)         (48)         (49)                                   
      Parasite Metazoan                                6 (12%)      4 (8%)       3 (6%)       7 (14%)                               
   Intestine Large, Cecum                             (47)         (49)         (48)         (48)                                   
      Dilatation                                                    1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                                                       1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (44)         (44)         (43)         (46)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Intestine Small, Ileum                             (42)         (45)         (43)         (45)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       5 (10%)      3 (6%)       7 (14%)                               
      Basophilic Focus                                29 (58%)     33 (66%)     27 (54%)     32 (64%)                               
      Clear Cell Focus                                 3 (6%)       7 (14%)      7 (14%)      2 (4%)                                
      Congestion                                                    2 (4%)                                                          
      Deformity                                        3 (6%)       6 (12%)      3 (6%)                                             
      Eosinophilic Focus                               6 (12%)      3 (6%)       7 (14%)      4 (8%)                                
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                       2 (4%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (4%)       3 (6%)      12 (24%)      4 (8%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                     12 (24%)      5 (10%)      9 (18%)     11 (22%)                               
      Mixed Cell Focus                                 4 (8%)       8 (16%)      5 (10%)      6 (12%)                               
      Necrosis                                         3 (6%)       2 (4%)       5 (10%)      1 (2%)                                
      Pigmentation, Bile                               1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
      Artery, Thrombosis                               1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Kupffer Cell, Pigmentation                                    1 (2%)                                                          
   Mesentery                                          (9)          (11)         (12)         (10)                                   
      Hemorrhage                                       1 (11%)                                                                      
      Fat, Necrosis                                    8 (89%)     10 (91%)     11 (92%)      9 (90%)                               
   Pancreas                                           (47)         (49)         (49)         (48)                                   
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Acinus, Atrophy                                 12 (26%)      4 (8%)       3 (6%)       5 (10%)                               
      Acinus, Hyperplasia                                           1 (2%)       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     5 (10%)      1 (2%)                    3 (6%)                                
      Ulcer                                            2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
      Epithelium, Hyperplasia                          4 (8%)       3 (6%)       3 (6%)       3 (6%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                        12 (24%)      6 (12%)      7 (14%)      7 (14%)                               
      Ulcer                                                                      2 (4%)                                             
   Tooth                                                           (1)                                                              
      Developmental Malformation                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  18 (36%)     21 (42%)     15 (30%)     11 (22%)                               
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Atrium, Inflammation, Chronic Active                          1 (2%)                                                          
      Atrium, Thrombosis                               4 (8%)       2 (4%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Angiectasis                                      7 (14%)      8 (16%)      9 (18%)     10 (20%)                               
      Cytoplasmic Alteration                           5 (10%)      3 (6%)       1 (2%)       4 (8%)                                
      Degeneration, Cystic                                          1 (2%)       1 (2%)                                             
      Hemorrhage                                       2 (4%)       3 (6%)                                                          
      Vacuolization Cytoplasmic                        4 (8%)       5 (10%)      7 (14%)      8 (16%)                               
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      5 (10%)                   1 (2%)       2 (4%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (46)         (49)         (48)         (48)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Metaplasia                                       1 (2%)                                                                       
   Parathyroid Gland                                  (50)         (50)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Necrosis                                                                                1 (2%)                                
      Pars Distalis, Angiectasis                       1 (2%)                    4 (8%)       1 (2%)                                
      Pars Distalis, Cyst                             13 (27%)     11 (22%)     11 (22%)     13 (26%)                               
      Pars Distalis, Hemorrhage                        2 (4%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                       4 (8%)       6 (12%)      6 (12%)                                            
      Pars Distalis, Pigmentation                                                             1 (2%)                                
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      C-Cell, Hyperplasia                             10 (20%)     11 (22%)      6 (12%)      8 (16%)                               
      Follicle, Cyst                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (49)         (49)         (49)                                   
      Atrophy                                                                                 2 (4%)                                
      Cyst                                             4 (8%)       4 (8%)       4 (8%)       6 (12%)                               
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)                                             
      Bilateral, Cyst                                                            1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             6 (12%)      4 (8%)      10 (20%)      8 (16%)                               
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
      Bilateral, Cyst                                  1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                                                          1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Abscess                                                                    1 (2%)                                             
      Cyst                                                          1 (2%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                       4 (8%)                    3 (6%)       4 (8%)                                
      Hyperplasia, Cystic                              1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       3 (6%)                                             
      Bilateral, Hydrometra                                                                   1 (2%)                                
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Vagina                                                          (2)                                                              
      Hemorrhage                                                    1 (50%)                                                         
      Infiltration Cellular, Polymorphonuclear                      1 (50%)                                                         
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Pigmentation                                                  1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (50)         (47)         (49)                                   
      Atrophy                                                                                 2 (4%)                                
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      1 (2%)       3 (6%)                    1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                        3 (6%)                                                                       
   Lymph Node                                         (11)         (9)          (15)         (7)                                    
      Hemorrhage                                       1 (9%)       2 (22%)      1 (7%)                                             
      Hyperplasia, Lymphoid                                                      1 (7%)                                             
      Pigmentation                                                               1 (7%)                                             
      Deep Cervical, Hemorrhage                        1 (9%)                    1 (7%)                                             
      Deep Cervical, Hyperplasia, Plasma Cell                                    1 (7%)                                             
      Deep Cervical, Pigmentation                                                1 (7%)                                             
      Iliac, Amyloid Deposition                                     1 (11%)                                                         
      Iliac, Hemorrhage                                2 (18%)      1 (11%)                                                         
      Iliac, Pigmentation                                           1 (11%)                                                         
      Mediastinal, Hemorrhage                          4 (36%)      2 (22%)      7 (47%)      1 (14%)                               
      Mediastinal, Hyperplasia, Lymphoid                                         1 (7%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (7%)                                             
      Mediastinal, Inflammation, Acute                              1 (11%)                                                         
      Mediastinal, Pigmentation                        2 (18%)                   5 (33%)                                            
      Pancreatic, Hemorrhage                           2 (18%)                   2 (13%)      1 (14%)                               
      Pancreatic, Hyperplasia, Histiocytic             1 (9%)                    1 (7%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                          1 (7%)                                             
      Renal, Hemorrhage                                3 (27%)      2 (22%)      4 (27%)      1 (14%)                               
      Renal, Hyperplasia, Histiocytic                  1 (9%)                                                                       
      Renal, Pigmentation                              1 (9%)       2 (22%)      1 (7%)       1 (14%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Atrophy                                          1 (2%)                                                                       
      Ectasia                                          1 (2%)                    1 (2%)                                             
      Hemorrhage                                       6 (12%)      4 (8%)       4 (8%)       2 (4%)                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Plasma Cell                         1 (2%)                    4 (8%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Pigmentation                                     1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Atrophy                                          2 (4%)                                                                       
      Hemorrhage                                       7 (14%)      3 (6%)       6 (12%)      5 (10%)                               
      Hyperplasia, Histiocytic                                      3 (6%)       4 (8%)       2 (4%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Pigmentation                                                  1 (2%)       1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Accessory Spleen                                                           1 (2%)                                             
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Fibrosis                                         3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 7 (14%)      2 (4%)       3 (6%)       1 (2%)                                
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
      Pigmentation                                     7 (14%)     11 (22%)      8 (16%)     10 (20%)                               
      Capsule, Cyst                                                                           1 (2%)                                
      Capsule, Fibrosis                                                                       2 (4%)                                
   Thymus                                             (48)         (49)         (50)         (50)                                   
      Atrophy                                         16 (33%)     10 (20%)     17 (34%)     14 (28%)                               
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Epithelial Cell, Hyperplasia                     7 (15%)      6 (12%)      9 (18%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Dilatation                                      34 (68%)     33 (66%)     25 (51%)     27 (54%)                               
      Hyperplasia                                     20 (40%)     23 (46%)     14 (29%)     19 (38%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Exudate                                                       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     6 (12%)      7 (14%)      7 (14%)      4 (8%)                                
      Malformation                                                               1 (2%)                                             
      Femur, Callus                                    1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Femur, Hyperostosis                              2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       2 (4%)       2 (4%)       3 (6%)       2 (4%)                                
   Spinal Cord                                        (2)          (1)                                                              
      Hemorrhage                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                                                          
      Hemorrhage                                       1 (2%)                    2 (4%)       2 (4%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)       2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                    3 (6%)       2 (4%)                                
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)                                                          
      Mediastinum, Necrosis                                                                   1 (2%)                                
   Nose                                               (50)         (48)         (49)         (49)                                   
      Foreign Body                                                               1 (2%)                                             
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Olfactory Epithelium, Degeneration, Hyaline      2 (4%)       9 (19%)      4 (8%)       3 (6%)                                
      Olfactory Epithelium, Inflammation, Chronic                                                                                   
          Active                                       2 (4%)       2 (4%)                                                          
      Respiratory Epithelium, Degeneration, Hyaline    6 (12%)      3 (6%)       8 (16%)     12 (24%)                               
      Respiratory Epithelium, Hyperplasia              1 (2%)      10 (21%)      1 (2%)       5 (10%)                               
      Respiratory Epithelium, Inflammation,                                                                                         
          Chronic Active                              13 (26%)      9 (19%)     18 (37%)      6 (12%)                               
      Respiratory Epithelium, Thrombosis                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (2)                                    
      External Ear, Hyperplasia                                                               1 (50%)                               
   Zymbal's Gland                                                  (1)          (1)                                                 
      Hyperplasia                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (46)         (49)         (50)         (50)                                   
      Casts                                                                      1 (2%)                                             
      Cyst                                             1 (2%)                                 2 (4%)                                
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Mineralization                                  24 (52%)     28 (57%)     26 (52%)     30 (60%)                               
      Nephropathy                                     23 (50%)     23 (47%)     15 (30%)     20 (40%)                               
      Pelvis, Mineralization                           1 (2%)                                                                       
      Renal Tubule, Degeneration, Hyaline              1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                       2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (49)                                   
      Dilatation                                                    1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     18           14           19           17                                     
    Moribund Sacrifice                                12           13            7           10                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                19           23           24           23                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (46)         (46)         (48)         (47)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Parasite Metazoan                                1 (2%)       3 (7%)       1 (2%)       2 (4%)                                
   Intestine Large, Rectum                            (45)         (47)         (46)         (47)                                   
      Parasite Metazoan                                3 (7%)       3 (6%)       3 (7%)       2 (4%)                                
   Intestine Large, Cecum                             (45)         (46)         (45)         (44)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (39)         (42)         (41)         (42)                                   
      Fibrosis                                                                                1 (2%)                                
   Intestine Small, Ileum                             (39)         (41)         (41)         (43)                                   
      Parasite Metazoan                                             1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      5 (10%)     11 (22%)      7 (14%)      9 (18%)                               
      Basophilic Focus                                 3 (6%)                                                                       
      Clear Cell Focus                                 7 (14%)      8 (16%)      7 (14%)      3 (6%)                                
      Congestion                                       2 (4%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Deformity                                        1 (2%)       2 (4%)       1 (2%)                                             
      Degeneration, Cystic                            12 (24%)      8 (16%)     12 (24%)     12 (24%)                               
      Eosinophilic Focus                               4 (8%)      10 (20%)     10 (20%)      3 (6%)                                
      Hemorrhage                                                    2 (4%)                                                          
      Hepatodiaphragmatic Nodule                       2 (4%)       3 (6%)       5 (10%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                 6 (12%)      6 (12%)      2 (4%)       5 (10%)                               
      Necrosis                                                                   1 (2%)       2 (4%)                                
      Vacuolization Cytoplasmic                        2 (4%)                    4 (8%)       1 (2%)                                
      Bile Duct, Hyperplasia                           1 (2%)       2 (4%)       3 (6%)                                             
      Centrilobular, Congestion                                     1 (2%)                                                          
      Centrilobular, Degeneration                      1 (2%)                    1 (2%)                                             
      Centrilobular, Vacuolization Cytoplasmic         1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Kupffer Cell, Pigmentation                       1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vein, Dilatation                                              1 (2%)                                                          
   Mesentery                                          (12)         (11)         (10)         (14)                                   
      Accessory Spleen                                                                        1 (7%)                                
      Inflammation, Chronic Active                                  1 (9%)                                                          
      Necrosis                                         1 (8%)                                                                       
      Pigmentation                                     1 (8%)                                                                       
      Fat, Necrosis                                    9 (75%)     10 (91%)      9 (90%)     12 (86%)                               
      Fat, Pigmentation                                                          1 (10%)                                            
   Oral Mucosa                                        (2)                                                                           
      Hyperplasia                                      1 (50%)                                                                      
   Pancreas                                           (48)         (45)         (46)         (48)                                   
      Acinus, Atrophy                                 10 (21%)      9 (20%)     13 (28%)     12 (25%)                               
      Acinus, Hyperplasia                                                        1 (2%)       3 (6%)                                
      Artery, Hyperplasia                              2 (4%)                                                                       
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (48)         (49)                                   
      Diverticulum                                                               1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       2 (4%)                                             
      Ulcer                                           10 (20%)     10 (20%)      8 (17%)     13 (27%)                               
      Epithelium, Hyperplasia                          3 (6%)       4 (8%)       2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (48)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Necrosis                                        17 (34%)     14 (29%)     13 (27%)     17 (34%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (48)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic Active                           1 (2%)                                                          
      Aorta, Mineralization                            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  35 (70%)     41 (82%)     42 (84%)     33 (66%)                               
      Fibrosis                                                                                1 (2%)                                
      Mineralization                                   2 (4%)                                 1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Atrium, Thrombosis                               3 (6%)                    6 (12%)      4 (8%)                                
      Ventricle, Pigmentation                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Cytoplasmic Alteration                                        2 (4%)       2 (4%)                                             
      Degeneration, Cystic                                                       1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                                                  3 (6%)                                             
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                     10 (20%)      8 (16%)      8 (16%)      4 (8%)                                
   Islets, Pancreatic                                 (49)         (45)         (46)         (47)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (48)         (49)         (50)         (47)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)                                             
   Pituitary Gland                                    (48)         (49)         (49)         (50)                                   
      Pars Distalis, Angiectasis                       3 (6%)       1 (2%)       3 (6%)       5 (10%)                               
      Pars Distalis, Cyst                              1 (2%)       3 (6%)       2 (4%)       2 (4%)                                
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                       8 (17%)      5 (10%)      5 (10%)      7 (14%)                               
      Pars Intermedia, Cyst                                         1 (2%)                    1 (2%)                                
      Pars Nervosa, Hemorrhage                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              4 (8%)       6 (12%)      5 (10%)      4 (8%)                                
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)                                    (1)                                    
      Necrosis                                         1 (33%)                                                                      
   Tissue NOS                                         (1)                                                                           
      Abdominal, Hemorrhage                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Penis                                              (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                             3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Fibrosis                                                                                1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     5 (10%)      1 (2%)       3 (6%)       5 (10%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                     4 (8%)       5 (10%)      7 (14%)      5 (10%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Testes                                             (50)         (49)         (50)         (50)                                   
      Atrophy                                          8 (16%)      9 (18%)     12 (24%)      8 (16%)                               
      Artery, Inflammation, Chronic Active                                       2 (4%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                   8 (16%)     11 (22%)     10 (20%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (45)         (47)         (49)                                   
      Atrophy                                          4 (9%)                    1 (2%)       3 (6%)                                
      Fibrosis                                                                   2 (4%)                                             
      Hyperplasia                                      2 (4%)       4 (9%)       2 (4%)       1 (2%)                                
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
   Lymph Node                                         (24)         (23)         (23)         (24)                                   
      Hemorrhage                                       1 (4%)       1 (4%)                    1 (4%)                                
      Iliac, Hemorrhage                                1 (4%)       1 (4%)                                                          
      Iliac, Hyperplasia, Lymphoid                                               1 (4%)                                             
      Iliac, Hyperplasia, Plasma Cell                               1 (4%)                                                          
      Mediastinal, Congestion                                                    1 (4%)                                             
      Mediastinal, Ectasia                                                       1 (4%)                                             
      Mediastinal, Hemorrhage                         11 (46%)     11 (48%)      8 (35%)     11 (46%)                               
      Mediastinal, Hyperplasia, Lymphoid               3 (13%)      2 (9%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell                         1 (4%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (4%)       1 (4%)                                             
      Mediastinal, Pigmentation                        3 (13%)      2 (9%)       1 (4%)                                             
      Pancreatic, Ectasia                                           1 (4%)                                                          
      Pancreatic, Hemorrhage                           1 (4%)       4 (17%)      2 (9%)       5 (21%)                               
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (4%)                                
      Renal, Ectasia                                                3 (13%)                                                         
      Renal, Hemorrhage                                3 (13%)      3 (13%)      1 (4%)       8 (33%)                               
      Renal, Hyperplasia, Lymphoid                                                            1 (4%)                                
      Renal, Hyperplasia, Plasma Cell                  1 (4%)                                                                       
      Renal, Pigmentation                              3 (13%)      4 (17%)      2 (9%)       7 (29%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Ectasia                                          1 (2%)       8 (16%)      2 (4%)       3 (6%)                                
      Hemorrhage                                       3 (6%)       1 (2%)       3 (6%)       2 (4%)                                
      Hyperplasia, Lymphoid                            5 (10%)      2 (4%)       3 (6%)       2 (4%)                                
      Hyperplasia, Plasma Cell                         2 (4%)       4 (8%)       5 (10%)      2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
      Ectasia                                          3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Hemorrhage                                       4 (8%)       4 (8%)       4 (8%)       6 (12%)                               
      Hyperplasia, Lymphoid                            4 (8%)       2 (4%)                    2 (4%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                                                                       
      Atrophy                                                       1 (2%)                                                          
      Congestion                                       3 (6%)                    2 (4%)                                             
      Cyst                                                                                    1 (2%)                                
      Fibrosis                                        10 (20%)     16 (32%)     19 (38%)     14 (28%)                               
      Hematopoietic Cell Proliferation                 3 (6%)       5 (10%)      2 (4%)       2 (4%)                                
      Necrosis                                         3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Pigmentation                                     2 (4%)                    2 (4%)       2 (4%)                                
      Capsule, Fibrosis                                2 (4%)       2 (4%)       2 (4%)                                             
      Capsule, Pigmentation                            1 (2%)                                 1 (2%)                                
   Thymus                                             (49)         (47)         (48)         (47)                                   
      Atrophy                                         30 (61%)     19 (40%)     18 (38%)     27 (57%)                               
      Hemorrhage                                       3 (6%)                    3 (6%)       2 (4%)                                
      Epithelial Cell, Hyperplasia                     5 (10%)      3 (6%)       2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (45)         (48)         (47)                                   
      Dilatation                                       8 (16%)     13 (29%)      9 (19%)      6 (13%)                               
      Hyperplasia                                      1 (2%)       3 (7%)       5 (10%)      6 (13%)                               
      Inflammation, Chronic Active                                                            2 (4%)                                
      Pigmentation                                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                   2 (4%)                                 1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       1 (2%)                                             
      Ulcer                                                                                   2 (4%)                                
      Epidermis, Hyperplasia                                        1 (2%)                                                          
      Hair Follicle, Atrophy                                                                  1 (2%)                                
      Subcutaneous Tissue, Fibrosis                                                           1 (2%)                                
      Subcutaneous Tissue, Foreign Body                                                       1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       4 (8%)                                
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Meninges, Angiectasis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)       1 (2%)       4 (8%)                                
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active                                               3 (6%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (8%)       1 (2%)       6 (12%)      1 (2%)                                
      Alveolus, Metaplasia, Squamous                                             1 (2%)                                             
   Nose                                               (50)         (47)         (49)         (50)                                   
      Foreign Body                                                  2 (4%)                    1 (2%)                                
      Nasopharyngeal Duct, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
      Olfactory Epithelium, Degeneration, Hyaline      1 (2%)                                 2 (4%)                                
      Olfactory Epithelium, Foreign Body               1 (2%)                                 1 (2%)                                
      Olfactory Epithelium, Hyperplasia                1 (2%)                                                                       
      Olfactory Epithelium, Inflammation, Chronic                                                                                   
          Active                                      10 (20%)      2 (4%)       6 (12%)      5 (10%)                               
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
      Respiratory Epithelium, Degeneration, Hyaline                 2 (4%)       1 (2%)                                             
      Respiratory Epithelium, Foreign Body             3 (6%)                                                                       
      Respiratory Epithelium, Hyperplasia             22 (44%)     20 (43%)     16 (33%)     28 (56%)                               
      Respiratory Epithelium, Inflammation                                       1 (2%)                                             
      Respiratory Epithelium, Inflammation, Chronic    1 (2%)                    1 (2%)       1 (2%)                                
      Respiratory Epithelium, Inflammation,                                                                                         
          Chronic Active                              22 (44%)     15 (32%)     22 (45%)     27 (54%)                               
      Respiratory Epithelium, Metaplasia                                                      1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     2 (4%)                                 1 (2%)                                
      Respiratory Epithelium, Thrombosis               4 (8%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
NTP Experiment-Test: 05160-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:29:54  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (2)                                    
      Atrophy                                                                                 2 (100%)                              
      Hemorrhage                                                    1 (100%)                                                        
      Lens, Cataract                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                                                                 1 (2%)                                
      Cyst                                             3 (6%)                    2 (4%)       3 (6%)                                
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Mineralization                                   2 (4%)                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Nephropathy                                     46 (92%)     46 (94%)     46 (94%)     49 (98%)                               
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)                                             
      Renal Tubule, Pigmentation                       4 (8%)       3 (6%)       4 (8%)       3 (6%)                                
   Urinary Bladder                                    (48)         (50)         (49)         (49)                                   
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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