Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/2584

TDMS Study 05160-05 Pathology Tables

NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97
Route: DOSED WATER                                                                                                Time: 08:36:37

                                                         2 YEAR CHRONIC




       Facility:  TSI Mason Research

       Chemical CAS #:  127-00-4

       Lock Date:  05/25/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            7            7            5                                     
    Natural Death                                     13           10           13           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           33           30           31                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (49)         (48)         (48)                                   
   Intestine Small, Jejunum                           (44)         (44)         (43)         (46)                                   
   Intestine Small, Ileum                             (42)         (45)         (43)         (45)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                                     1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Mesentery                                          (9)          (11)         (12)         (10)                                   
      Histiocytic Sarcoma                              1 (11%)                                                                      
   Oral Mucosa                                                     (1)          (1)                                                 
      Squamous Cell Carcinoma                                       1 (100%)                                                        
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Pancreas                                           (47)         (49)         (49)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Acinus, Adenoma                                                                         1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (2)          (2)                       (1)                                    
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                    1 (50%)                                                         
      Squamous Cell Papilloma                          2 (100%)     1 (50%)                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Ganglioneuroma                                                                          1 (2%)                                
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)                    1 (2%)                                
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (4%)       4 (8%)       1 (2%)       4 (8%)                                
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (46)         (49)         (48)         (48)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          29 (59%)     30 (60%)     32 (64%)     35 (70%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Distalis, Histiocytic Sarcoma                                         1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      C-Cell, Adenoma                                  2 (4%)       8 (16%)      5 (10%)      3 (6%)                                
      C-Cell, Carcinoma                                                          1 (2%)       2 (4%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Abdominal, Sarcoma                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (49)         (49)         (49)                                   
      Adenoma                                          1 (2%)                    2 (4%)       4 (8%)                                
      Carcinoma                                        2 (4%)       3 (6%)       2 (4%)       3 (6%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Bilateral, Carcinoma                             2 (4%)       1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cystadenoma                                                                1 (2%)                                             
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
      Granulosa-Theca Tumor Malignant                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Polyp Stromal                                    6 (12%)      6 (12%)      6 (12%)      4 (8%)                                
      Bilateral, Polyp Stromal                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (50)         (47)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Lymph Node                                         (11)         (9)          (15)         (7)                                    
      Mediastinal, Histiocytic Sarcoma                                           1 (7%)                                             
      Pancreatic, Histiocytic Sarcoma                                            1 (7%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (48)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Thymoma Benign                                                1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Fibroadenoma                                    21 (42%)     21 (42%)     26 (53%)     14 (28%)                               
      Fibroadenoma, Multiple                           8 (16%)      7 (14%)      5 (10%)      9 (18%)                               
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                    1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Melanoma Malignant                       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Melanoma Malignant, Metastatic, Skin                          1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Pheochromocytoma Complex, Metastatic,                                                                                         
          Adrenal Medulla                              1 (2%)                                                                       
   Nose                                               (50)         (48)         (49)         (49)                                   
      Respiratory Epithelium, Histiocytic Sarcoma                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (46)         (49)         (50)         (50)                                   
      Mesenchymal Tumor Malignant                                                1 (2%)                                             
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Papilloma                                                                               1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            19 (38%)     19 (38%)     18 (36%)     13 (26%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          46          49          48                                       
     Total Primary Neoplasms                          107         111         112         104                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          42          48          42                                       
     Total Benign Neoplasms                            76          81          83          83                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          24          26          18                                       
     Total Malignant Neoplasms                         31          30          29          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           1                                                   
     Total Metastatic Neoplasm                          1           2           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     18           14           19           17                                     
    Moribund Sacrifice                                12           13            7           10                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                19           23           24           23                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Intestine Large, Colon                             (46)         (46)         (48)         (47)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Intestine Large, Cecum                             (45)         (46)         (45)         (44)                                   
   Intestine Small, Duodenum                          (46)         (45)         (46)         (48)                                   
   Intestine Small, Jejunum                           (39)         (42)         (41)         (42)                                   
   Intestine Small, Ileum                             (39)         (41)         (41)         (43)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                                   1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Mesentery                                          (12)         (11)         (10)         (14)                                   
      Lipoma                                                                                  1 (7%)                                
   Oral Mucosa                                        (2)                                                                           
      Squamous Cell Papilloma                          1 (50%)                                                                      
   Pancreas                                           (48)         (45)         (46)         (48)                                   
      Acinus, Adenoma                                  1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Stomach, Forestomach                               (50)         (49)         (48)         (49)                                   
   Stomach, Glandular                                 (50)         (49)         (48)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (48)         (50)         (50)         (50)                                   
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)       2 (4%)                                
      Pheochromocytoma Benign                          7 (14%)     13 (27%)     13 (27%)     11 (22%)                               
      Bilateral, Pheochromocytoma Benign               6 (12%)      1 (2%)       4 (8%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (45)         (46)         (47)                                   
      Adenoma                                          2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (48)         (49)         (49)         (50)                                   
      Pars Distalis, Adenoma                          15 (31%)     20 (41%)     25 (51%)     24 (48%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  5 (10%)      1 (2%)       6 (12%)      3 (6%)                                
      C-Cell, Carcinoma                                             2 (4%)                    1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)                                    (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Carcinoma                                        1 (2%)       4 (8%)       4 (8%)       3 (6%)                                
      Bilateral, Carcinoma                                                       1 (2%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (49)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           36 (72%)     32 (65%)     31 (62%)     34 (68%)                               
      Interstitial Cell, Adenoma                      10 (20%)     11 (22%)      9 (18%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (45)         (47)         (49)                                   
   Lymph Node                                         (24)         (23)         (23)         (24)                                   
      Iliac, Squamous Cell Carcinoma, Metastatic,                                                                                   
           Skin                                                     1 (4%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                

                                                             Page   8                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (49)         (47)         (48)         (47)                                   
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (45)         (48)         (47)                                   
      Fibroadenoma                                     7 (14%)                   5 (10%)      6 (13%)                               
      Fibroadenoma, Multiple                                                     1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)       3 (6%)       3 (6%)       6 (12%)                               
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Multiple                             1 (2%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (6%)       8 (16%)      7 (14%)      6 (12%)                               
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Melanoma Malignant                       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                                            1 (2%)                                
      Vertebra, Osteosarcoma                           1 (2%)                                                                       
   Skeletal Muscle                                    (2)                                    (1)                                    
      Histiocytic Sarcoma                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             2 (4%)       1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
   Nose                                               (50)         (47)         (49)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Respiratory Epithelium, Adenoma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                           (1)                                    
      Histiocytic Sarcoma                                                                     1 (100%)                              
   Zymbal's Gland                                     (1)          (3)          (3)                                                 
      Carcinoma                                        1 (100%)     3 (100%)     3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Renal Tubule, Adenoma                                                      1 (2%)       1 (2%)                                
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (48)         (50)         (49)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Leukemia Mononuclear                            32 (64%)     33 (66%)     30 (60%)     31 (62%)                               
      Mesothelioma Malignant                           3 (6%)                    1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05160-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 08:36:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      325 PPM      650 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50          50          50                                       
     Total Primary Neoplasms                          141         148         156         161                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          48          48          50                                       
     Total Benign Neoplasms                            99         101         112         116                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          38          37          37                                       
     Total Malignant Neoplasms                         42          47          44          45                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4                       1                                       
     Total Metastatic Neoplasm                          3           5                       1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               2           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------