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TDMS Study 05160-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97

EXPERIMENT: 05160 TEST: 05                                                                                     TIME: 09:05:53
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C
PATHOLOGIST: STEDHAM, M.                                                                                       CAS: 127-00-4
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97     
EXPERIMENT: 05160 TEST: 05                                                                                     TIME: 09:05:53     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C     
PATHOLOGIST: STEDHAM, M.                                                                                       CAS: 127-00-4      


SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF          1-CHLORO-2-PROPANOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or UnspeAdenomaSite
                                       Carcinoma or Adenoma
Testes                                 Adenoma
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Clitoral/Preputial Gland               Adenoma
Mammary Gland                          Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Thyroid Gland: C-Cell                  Adenoma
                                       Carcinoma or Adenoma
===============================================================
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)        -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  14/49 (29%)  17/49 (35%)  12/50 (24%) |2/49 (4%)    5/50 (10%)   1/50 (2%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     32.7%        33.5%        41.4%        28.1%       |4.6%         10.8%        2.3%         8.9%         |
|TERMINAL (d)       |     8/20 (40%)   8/23 (35%)   11/24 (46%)  8/23 (35%)  |0/25 (0%)    3/33 (9%)    1/30 (3%)    3/31 (10%)   |
|FIRST INCIDENCE    |     580          609          627          585         |659          627          734 (T)      693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.341N     P=0.494N     P=0.447      P=0.353N    |P=0.477      P=0.308      P=0.463N     P=0.407      |
|POLY 3             |     P=0.375N     P=0.585      P=0.295      P=0.433N    |P=0.451      P=0.256      P=0.524N     P=0.370      |
|POLY 1.5           |     P=0.403N     P=0.537      P=0.268      P=0.458N    |P=0.446      P=0.240      P=0.510N     P=0.358      |
|POLY 6             |     P=0.351N     P=0.611N     P=0.339      P=0.409N    |P=0.462      P=0.284      P=0.544N     P=0.391      |
|LOGISTIC REGRESSION|     P=0.348N     P=0.546N     P=0.330      P=0.375N    |P=0.441      P=0.223      P=0.493N     P=0.352      |
|COCH-ARM / FISHERS |     P=0.452N     P=0.475      P=0.235      P=0.500N    |P=0.441      P=0.226      P=0.492N     P=0.349      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    1/49 (2%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         2.5%         4.8%        |2.3%         2.2%         0.0%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    2/23 (9%)   |0/25 (0%)    1/33 (3%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     693          ---          729 (T)      729 (T)     |701          734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.257      P=0.467N     P=0.736N     P=0.536     |P=0.590N     P=0.714N     P=0.489N     P=0.730N     |
|POLY 3             |     P=0.271      P=0.585N     P=0.807N     P=0.580     |P=0.627N     P=0.773N     P=0.548N     P=0.782N     |
|POLY 1.5           |     P=0.259      P=0.548N     P=0.788N     P=0.545     |P=0.618N     P=0.767N     P=0.525N     P=0.771N     |
|POLY 6             |     P=0.289      P=0.643N     P=0.836N     P=0.629     |P=0.639N     P=0.782N     P=0.584N     P=0.797N     |
|LOGISTIC REGRESSION|     P=0.258      P=0.489N     P=0.746N     P=0.543     |P=0.605N     P=0.747N     P=0.496N     P=0.752N     |
|COCH-ARM / FISHERS |     P=0.243      P=0.505N     P=0.747      P=0.500     |P=0.609N     P=0.747N     P=0.495N     P=0.747N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  14/49 (29%)  18/49 (37%)  13/50 (26%) |4/49 (8%)    5/50 (10%)   1/50 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     35.1%        33.5%        43.8%        30.4%       |9.1%         10.8%        2.3%         11.2%        |
|TERMINAL (d)       |     8/20 (40%)   8/23 (35%)   12/24 (50%)  9/23 (39%)  |0/25 (0%)    3/33 (9%)    1/30 (3%)    4/31 (13%)   |
|FIRST INCIDENCE    |     580          609          627          585         |629          627          734 (T)      693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.370N     P=0.403N     P=0.457      P=0.350N    |P=0.568      P=0.603      P=0.166N     P=0.576      |
|POLY 3             |     P=0.413N     P=0.552N     P=0.295      P=0.432N    |P=0.535      P=0.547      P=0.191N     P=0.528      |
|POLY 1.5           |     P=0.439N     P=0.578N     P=0.269      P=0.457N    |P=0.534      P=0.528      P=0.183N     P=0.519      |
|POLY 6             |     P=0.393N     P=0.519N     P=0.334      P=0.410N    |P=0.538      P=0.576      P=0.203N     P=0.543      |
|LOGISTIC REGRESSION|     P=0.376N     P=0.449N     P=0.337      P=0.367N    |P=0.534      P=0.510      P=0.172N     P=0.514      |
|COCH-ARM / FISHERS |     P=0.485N     P=0.563      P=0.238      P=0.500N    |P=0.534      P=0.513      P=0.175N     P=0.513      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    2/49 (4%)   |1/49 (2%)    0/49 (0%)    2/49 (4%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.4%         4.9%         4.9%        |2.3%         0.0%         4.6%         9.1%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    2/24 (8%)    2/23 (9%)   |1/25 (4%)    0/32 (0%)    1/29 (3%)    3/31 (10%)   |
|FIRST INCIDENCE    |     709          729 (T)      729 (T)      729 (T)     |734 (T)      ---          608          649          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.367      P=0.723N     P=0.560      P=0.546     |P=0.046 *    P=0.451N     P=0.532      P=0.239      |
|POLY 3             |     P=0.369      P=0.798N     P=0.575      P=0.574     |P=0.039 *    P=0.539N     P=0.537      P=0.202      |
|POLY 1.5           |     P=0.352      P=0.781N     P=0.542      P=0.538     |P=0.038 *    P=0.523N     P=0.519      P=0.190      |
|POLY 6             |     P=0.393      P=0.825N     P=0.624      P=0.625     |P=0.041 *    P=0.565N     P=0.567      P=0.223      |
|LOGISTIC REGRESSION|     P=0.357      P=0.731N     P=0.539      P=0.543     |P=0.038 *    (e)          P=0.500      P=0.189      |
|COCH-ARM / FISHERS |     P=0.327      P=0.753N     P=0.500      P=0.492     |P=0.038 *    P=0.500N     P=0.500      P=0.181      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    5/50 (10%)   3/49 (6%)   |4/49 (8%)    4/49 (8%)    2/49 (4%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     2.6%         9.6%         12.0%        7.2%        |9.3%         8.9%         4.6%         6.9%         |
|TERMINAL (d)       |     1/20 (5%)    4/23 (17%)   2/24 (8%)    2/23 (9%)   |4/25 (16%)   2/32 (6%)    2/29 (7%)    2/31 (7%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      592          585         |734 (T)      708          734 (T)      693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.384      P=0.218      P=0.140      P=0.353     |P=0.303N     P=0.516N     P=0.267N     P=0.391N     |
|POLY 3             |     P=0.394      P=0.232      P=0.138      P=0.373     |P=0.371N     P=0.634N     P=0.354N     P=0.510N     |
|POLY 1.5           |     P=0.365      P=0.208      P=0.121      P=0.340     |P=0.369N     P=0.642N     P=0.347N     P=0.507N     |
|POLY 6             |     P=0.432      P=0.271      P=0.168      P=0.424     |P=0.372N     P=0.620N     P=0.363N     P=0.510N     |
|LOGISTIC REGRESSION|     P=0.355      P=0.218      P=0.110      P=0.323     |P=0.341N     P=0.562N     P=0.267N     P=0.447N     |
|COCH-ARM / FISHERS |     P=0.325      P=0.181      P=0.102      P=0.301     |P=0.364N     P=0.643N     P=0.339N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   7/50 (14%)   5/49 (10%)  |5/49 (10%)   4/49 (8%)    4/49 (8%)    7/49 (14%)   |
|POLY-3 ADJUSTED (b)|     5.1%         12.0%        16.8%        12.0%       |11.7%        8.9%         9.2%         15.9%        |
|TERMINAL (d)       |     1/20 (5%)    5/23 (22%)   4/24 (17%)   4/23 (17%)  |5/25 (20%)   2/32 (6%)    3/29 (10%)   5/31 (16%)   |
|FIRST INCIDENCE    |     709          729 (T)      592          585         |734 (T)      708          608          649          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.270      P=0.276      P=0.125      P=0.272     |P=0.326      P=0.361N     P=0.418N     P=0.519      |
|POLY 3             |     P=0.267      P=0.273      P=0.109      P=0.271     |P=0.268      P=0.487N     P=0.507N     P=0.413      |
|POLY 1.5           |     P=0.243      P=0.248      P=0.095      P=0.243     |P=0.265      P=0.497N     P=0.505N     P=0.395      |
|POLY 6             |     P=0.298      P=0.313      P=0.132      P=0.312     |P=0.278      P=0.469N     P=0.508N     P=0.447      |
|LOGISTIC REGRESSION|     P=0.248      P=0.285      P=0.093      P=0.251     |P=0.263      P=0.405N     P=0.481N     P=0.423      |
|COCH-ARM / FISHERS |     P=0.211      P=0.218      P=0.080      P=0.210     |P=0.259      P=0.500N     P=0.500N     P=0.380      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    1/45 (2%)    2/46 (4%)    3/47 (6%)   |1/46 (2%)    1/49 (2%)    1/48 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         2.6%         5.2%         7.7%        |2.5%         2.2%         2.3%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    1/24 (4%)    3/23 (13%)  |0/25 (0%)    1/33 (3%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     637          729 (T)      667          729 (T)     |729          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.351      P=0.461N     P=0.645N     P=0.561     |P=0.279N     P=0.706N     P=0.724N     P=0.460N     |
|POLY 3             |     P=0.333      P=0.557N     P=0.734N     P=0.555     |P=0.314N     P=0.764N     P=0.777N     P=0.531N     |
|POLY 1.5           |     P=0.320      P=0.544N     P=0.709      P=0.523     |P=0.310N     P=0.758N     P=0.765N     P=0.513N     |
|POLY 6             |     P=0.349      P=0.579N     P=0.749N     P=0.599     |P=0.321N     P=0.774N     P=0.792N     P=0.559N     |
|LOGISTIC REGRESSION|     P=0.329      P=0.495N     P=0.696N     P=0.538     |P=0.286N     P=0.724N     P=0.739N     P=0.474N     |
|COCH-ARM / FISHERS |     P=0.301      P=0.532N     P=0.667      P=0.480     |P=0.304N     P=0.737N     P=0.742N     P=0.489N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    1/45 (2%)    2/46 (4%)    4/47 (9%)   |1/46 (2%)    2/49 (4%)    1/48 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         2.6%         5.2%         10.2%       |2.5%         4.5%         2.3%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    1/24 (4%)    4/23 (17%)  |0/25 (0%)    2/33 (6%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     637          729 (T)      667          729 (T)     |729          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.192      P=0.461N     P=0.645N     P=0.402     |P=0.209N     P=0.587      P=0.724N     P=0.460N     |
|POLY 3             |     P=0.176      P=0.557N     P=0.734N     P=0.386     |P=0.239N     P=0.559      P=0.777N     P=0.531N     |
|POLY 1.5           |     P=0.168      P=0.544N     P=0.709      P=0.356     |P=0.237N     P=0.541      P=0.765N     P=0.513N     |
|POLY 6             |     P=0.186      P=0.579N     P=0.749N     P=0.428     |P=0.241N     P=0.587      P=0.792N     P=0.559N     |
|LOGISTIC REGRESSION|     P=0.176      P=0.495N     P=0.696N     P=0.378     |P=0.214N     P=0.564      P=0.739N     P=0.474N     |
|COCH-ARM / FISHERS |     P=0.156      P=0.532N     P=0.667      P=0.319     |P=0.234N     P=0.524      P=0.742N     P=0.489N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/49 (4%)    1/50 (2%)   |0/46 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    2/24 (8%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.259      (e)          P=0.278      P=0.528     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.285      (e)          P=0.305      P=0.611     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.266      (e)          P=0.271      P=0.561     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.312      (e)          P=0.360      P=0.684     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.278      P=0.528     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.242      (e)          P=0.242      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         7.1%         2.5%         4.8%        |0.0%         0.0%         2.3%         2.2%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    1/24 (4%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     729 (T)      630          729 (T)      676         |---          ---          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.583      P=0.356      P=0.722N     P=0.554     |P=0.250      (e)          P=0.536      P=0.543      |
|POLY 3             |     P=0.588      P=0.379      P=0.805N     P=0.583     |P=0.251      (e)          P=0.556      P=0.556      |
|POLY 1.5           |     P=0.566      P=0.345      P=0.785N     P=0.546     |P=0.242      (e)          P=0.530      P=0.530      |
|POLY 6             |     P=0.617      P=0.431      P=0.836N     P=0.635     |P=0.265      (e)          P=0.598      P=0.598      |
|LOGISTIC REGRESSION|     P=0.565      P=0.341      P=0.722N     P=0.540     |(e)          (e)          P=0.536      P=0.543      |
|COCH-ARM / FISHERS |     P=0.536      P=0.309      P=0.753N     P=0.500     |P=0.231      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         7.1%         4.9%         7.1%        |0.0%         0.0%         2.3%         2.2%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    2/24 (8%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     729 (T)      630          729 (T)      569         |---          ---          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.354      P=0.356      P=0.564      P=0.356     |P=0.250      (e)          P=0.536      P=0.543      |
|POLY 3             |     P=0.360      P=0.379      P=0.576      P=0.382     |P=0.251      (e)          P=0.556      P=0.556      |
|POLY 1.5           |     P=0.338      P=0.345      P=0.542      P=0.348     |P=0.242      (e)          P=0.530      P=0.530      |
|POLY 6             |     P=0.390      P=0.431      P=0.627      P=0.434     |P=0.265      (e)          P=0.598      P=0.598      |
|LOGISTIC REGRESSION|     P=0.328      P=0.341      P=0.564      P=0.311     |(e)          (e)          P=0.536      P=0.543      |
|COCH-ARM / FISHERS |     P=0.308      P=0.309      P=0.500      P=0.309     |P=0.231      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         7.1%         4.9%         7.1%        |0.0%         0.0%         2.3%         2.2%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    2/24 (8%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     729 (T)      630          729 (T)      569         |---          ---          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.354      P=0.356      P=0.564      P=0.356     |P=0.250      (e)          P=0.536      P=0.543      |
|POLY 3             |     P=0.360      P=0.379      P=0.576      P=0.382     |P=0.251      (e)          P=0.556      P=0.556      |
|POLY 1.5           |     P=0.338      P=0.345      P=0.542      P=0.348     |P=0.242      (e)          P=0.530      P=0.530      |
|POLY 6             |     P=0.390      P=0.431      P=0.627      P=0.434     |P=0.265      (e)          P=0.598      P=0.598      |
|LOGISTIC REGRESSION|     P=0.328      P=0.341      P=0.564      P=0.311     |(e)          (e)          P=0.536      P=0.543      |
|COCH-ARM / FISHERS |     P=0.308      P=0.309      P=0.500      P=0.309     |P=0.231      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.7%         2.5%         0.0%        |0.0%         0.0%         0.0%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    1/24 (4%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     ---          388          729 (T)      ---         |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426N     P=0.257      P=0.536      (e)         |P=0.208      (e)          (e)          P=0.543      |
|POLY 3             |     P=0.447N     P=0.314      P=0.611      (e)         |P=0.220      (e)          (e)          P=0.556      |
|POLY 1.5           |     P=0.444N     P=0.279      P=0.561      (e)         |P=0.210      (e)          (e)          P=0.530      |
|POLY 6             |     P=0.459N     P=0.371      P=0.685      (e)         |P=0.237      (e)          (e)          P=0.598      |
|LOGISTIC REGRESSION|     P=0.497N     P=0.171      P=0.536      (e)         |(e)          (e)          (e)          P=0.543      |
|COCH-ARM / FISHERS |     P=0.446N     P=0.247      P=0.500      (e)         |P=0.196      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          686          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.255      (e)          P=0.267      P=0.528     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.284      (e)          P=0.310      P=0.611     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.265      (e)          P=0.276      P=0.561     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.312      (e)          P=0.365      P=0.684     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.255      (e)          P=0.253      P=0.528     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.240      (e)          P=0.247      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.7%         7.3%         2.4%        |0.0%         0.0%         0.0%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    2/24 (8%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     ---          388          686          729 (T)     |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.478      P=0.257      P=0.149      P=0.528     |P=0.208      (e)          (e)          P=0.543      |
|POLY 3             |     P=0.509      P=0.314      P=0.161      P=0.611     |P=0.220      (e)          (e)          P=0.556      |
|POLY 1.5           |     P=0.484      P=0.279      P=0.141      P=0.561     |P=0.210      (e)          (e)          P=0.530      |
|POLY 6             |     P=0.541      P=0.371      P=0.196      P=0.684     |P=0.237      (e)          (e)          P=0.598      |
|LOGISTIC REGRESSION|     P=0.441      P=0.171      P=0.135      P=0.528     |(e)          (e)          (e)          P=0.543      |
|COCH-ARM / FISHERS |     P=0.449      P=0.247      P=0.121      P=0.500     |P=0.196      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.3%         4.3%         2.2%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    1/33 (3%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729          627          608          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.230N     P=0.562      P=0.748N     P=0.460N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.251N     P=0.544      P=0.785N     P=0.549N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.522      P=0.774N     P=0.527N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.254N     P=0.579      P=0.800N     P=0.582N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.241N     P=0.498      P=0.759N     P=0.478N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.241N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   0/50 (0%)    6/50 (12%)   6/50 (12%)  |29/50 (58%)  28/50 (56%)  31/50 (62%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     17.7%        0.0%         14.6%        14.2%       |62.1%        59.3%        67.6%        50.6%        |
|TERMINAL (d)       |     5/20 (25%)   0/23 (0%)    5/24 (21%)   3/23 (13%)  |16/25 (64%)  21/33 (64%)  22/30 (73%)  17/31 (55%)  |
|FIRST INCIDENCE    |     585          ---          573          648         |541          627          608          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426      P=0.006N**   P=0.386N     P=0.405N    |P=0.068N     P=0.135N     P=0.438N     P=0.050N     |
|POLY 3             |     P=0.394      P=0.007N**   P=0.496N     P=0.474N    |P=0.175N     P=0.479N     P=0.371      P=0.182N     |
|POLY 1.5           |     P=0.382      P=0.007N**   P=0.496N     P=0.483N    |P=0.158N     P=0.504N     P=0.388      P=0.173N     |
|POLY 6             |     P=0.410      P=0.008N**   P=0.501N     P=0.471N    |P=0.200N     P=0.435N     P=0.362      P=0.192N     |
|LOGISTIC REGRESSION|     P=0.409      P=0.006N**   P=0.448N     P=0.422N    |P=0.131N     P=0.438N     P=0.433      P=0.132N     |
|COCH-ARM / FISHERS |     P=0.366      P=0.006N**   P=0.500N     P=0.500N    |P=0.141N     P=0.500N     P=0.419      P=0.158N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   0/50 (0%)    6/50 (12%)   6/50 (12%)  |29/50 (58%)  28/50 (56%)  31/50 (62%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     17.7%        0.0%         14.6%        14.2%       |62.1%        59.3%        67.6%        50.6%        |
|TERMINAL (d)       |     5/20 (25%)   0/23 (0%)    5/24 (21%)   3/23 (13%)  |16/25 (64%)  21/33 (64%)  22/30 (73%)  17/31 (55%)  |
|FIRST INCIDENCE    |     585          ---          573          648         |541          627          608          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426      P=0.006N**   P=0.386N     P=0.405N    |P=0.068N     P=0.135N     P=0.438N     P=0.050N     |
|POLY 3             |     P=0.394      P=0.007N**   P=0.496N     P=0.474N    |P=0.175N     P=0.479N     P=0.371      P=0.182N     |
|POLY 1.5           |     P=0.382      P=0.007N**   P=0.496N     P=0.483N    |P=0.158N     P=0.504N     P=0.388      P=0.173N     |
|POLY 6             |     P=0.410      P=0.008N**   P=0.501N     P=0.471N    |P=0.200N     P=0.435N     P=0.362      P=0.192N     |
|LOGISTIC REGRESSION|     P=0.409      P=0.006N**   P=0.448N     P=0.422N    |P=0.131N     P=0.438N     P=0.433      P=0.132N     |
|COCH-ARM / FISHERS |     P=0.366      P=0.006N**   P=0.500N     P=0.500N    |P=0.141N     P=0.500N     P=0.419      P=0.158N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   0/50 (0%)    6/50 (12%)   6/50 (12%)  |30/50 (60%)  28/50 (56%)  31/50 (62%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     17.7%        0.0%         14.6%        14.2%       |64.2%        59.3%        67.6%        50.6%        |
|TERMINAL (d)       |     5/20 (25%)   0/23 (0%)    5/24 (21%)   3/23 (13%)  |16/25 (64%)  21/33 (64%)  22/30 (73%)  17/31 (55%)  |
|FIRST INCIDENCE    |     585          ---          573          648         |541          627          608          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426      P=0.006N**   P=0.386N     P=0.405N    |P=0.051N     P=0.101N     P=0.369N     P=0.035N*    |
|POLY 3             |     P=0.394      P=0.007N**   P=0.496N     P=0.474N    |P=0.133N     P=0.395N     P=0.456      P=0.130N     |
|POLY 1.5           |     P=0.382      P=0.007N**   P=0.496N     P=0.483N    |P=0.119N     P=0.421N     P=0.471      P=0.124N     |
|POLY 6             |     P=0.410      P=0.008N**   P=0.501N     P=0.471N    |P=0.153N     P=0.349N     P=0.449      P=0.136N     |
|LOGISTIC REGRESSION|     P=0.409      P=0.006N**   P=0.448N     P=0.422N    |P=0.097N     P=0.353N     P=0.518      P=0.091N     |
|COCH-ARM / FISHERS |     P=0.366      P=0.006N**   P=0.500N     P=0.500N    |P=0.107N     P=0.420N     P=0.500      P=0.115N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         0.0%        |4.6%         2.2%         2.3%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |2/25 (8%)    1/33 (3%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     579          ---          ---          ---         |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.308N     P=0.491N     P=0.500N     P=0.491N    |P=0.368N     P=0.403N     P=0.436N     P=0.425N     |
|POLY 3             |     P=0.371N     P=0.583N     P=0.593N     P=0.582N    |P=0.429N     P=0.512N     P=0.528N     P=0.525N     |
|POLY 1.5           |     P=0.343N     P=0.545N     P=0.550N     P=0.543N    |P=0.422N     P=0.509N     P=0.516N     P=0.514N     |
|POLY 6             |     P=0.417N     P=0.642N     P=0.658N     P=0.644N    |P=0.440N     P=0.517N     P=0.546N     P=0.538N     |
|LOGISTIC REGRESSION|     P=0.354N     P=0.547N     P=0.536N     P=0.588N    |P=0.368N     P=0.403N     P=0.436N     P=0.425N     |
|COCH-ARM / FISHERS |     P=0.311N     P=0.500N     P=0.500N     P=0.500N    |P=0.412N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         0.0%        |4.6%         4.4%         2.3%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |2/25 (8%)    1/33 (3%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     579          ---          ---          ---         |734 (T)      708          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.308N     P=0.491N     P=0.500N     P=0.491N    |P=0.295N     P=0.601N     P=0.436N     P=0.425N     |
|POLY 3             |     P=0.371N     P=0.583N     P=0.593N     P=0.582N    |P=0.347N     P=0.698N     P=0.528N     P=0.525N     |
|POLY 1.5           |     P=0.343N     P=0.545N     P=0.550N     P=0.543N    |P=0.342N     P=0.699N     P=0.516N     P=0.514N     |
|POLY 6             |     P=0.417N     P=0.642N     P=0.658N     P=0.644N    |P=0.353N     P=0.698N     P=0.546N     P=0.538N     |
|LOGISTIC REGRESSION|     P=0.354N     P=0.547N     P=0.536N     P=0.588N    |P=0.312N     P=0.642N     P=0.436N     P=0.425N     |
|COCH-ARM / FISHERS |     P=0.311N     P=0.500N     P=0.500N     P=0.500N    |P=0.334N     P=0.691N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/48 (31%)  20/49 (41%)  25/49 (51%)  24/50 (48%) |29/49 (59%)  30/50 (60%)  32/50 (64%)  35/50 (70%)  |
|POLY-3 ADJUSTED (b)|     37.4%        46.9%        57.2%        53.2%       |62.9%        63.6%        66.5%        73.5%        |
|TERMINAL (d)       |     7/20 (35%)   12/23 (52%)  13/24 (54%)  15/23 (65%) |17/25 (68%)  21/33 (64%)  19/30 (63%)  23/31 (74%)  |
|FIRST INCIDENCE    |     502          502          559          502         |541          676          506          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.116      P=0.378      P=0.127      P=0.144     |P=0.315      P=0.210N     P=0.514N     P=0.507      |
|POLY 3             |     P=0.090      P=0.264      P=0.052      P=0.106     |P=0.132      P=0.565      P=0.444      P=0.185      |
|POLY 1.5           |     P=0.075      P=0.246      P=0.044 *    P=0.089     |P=0.130      P=0.541      P=0.417      P=0.178      |
|POLY 6             |     P=0.110      P=0.292      P=0.070      P=0.128     |P=0.143      P=0.580N     P=0.487      P=0.210      |
|LOGISTIC REGRESSION|     P=0.070      P=0.285      P=0.045 *    P=0.087     |P=0.122      P=0.559N     P=0.387      P=0.180      |
|COCH-ARM / FISHERS |     P=0.057      P=0.221      P=0.038 *    P=0.068     |P=0.127      P=0.548      P=0.387      P=0.180      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/48 (31%)  20/49 (41%)  25/49 (51%)  24/50 (48%) |30/49 (61%)  30/50 (60%)  32/50 (64%)  35/50 (70%)  |
|POLY-3 ADJUSTED (b)|     37.4%        46.9%        57.2%        53.2%       |65.0%        63.6%        66.5%        73.5%        |
|TERMINAL (d)       |     7/20 (35%)   12/23 (52%)  13/24 (54%)  15/23 (65%) |17/25 (68%)  21/33 (64%)  19/30 (63%)  23/31 (74%)  |
|FIRST INCIDENCE    |     502          502          559          502         |541          676          506          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.116      P=0.378      P=0.127      P=0.144     |P=0.368      P=0.164N     P=0.447N     P=0.556N     |
|POLY 3             |     P=0.090      P=0.264      P=0.052      P=0.106     |P=0.173      P=0.537N     P=0.528      P=0.247      |
|POLY 1.5           |     P=0.075      P=0.246      P=0.044 *    P=0.089     |P=0.170      P=0.552N     P=0.501      P=0.239      |
|POLY 6             |     P=0.110      P=0.292      P=0.070      P=0.128     |P=0.184      P=0.498N     P=0.571      P=0.275      |
|LOGISTIC REGRESSION|     P=0.070      P=0.285      P=0.045 *    P=0.087     |P=0.160      P=0.474N     P=0.469      P=0.240      |
|COCH-ARM / FISHERS |     P=0.057      P=0.221      P=0.038 *    P=0.068     |P=0.166      P=0.532N     P=0.469      P=0.240      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   3/50 (6%)    7/50 (14%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.7%         14.1%        7.4%         16.5%       |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   3/23 (13%)   2/24 (8%)    3/23 (13%)  |1/25 (4%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     697          544          720          582         |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.226      P=0.326      P=0.586N     P=0.222     |P=0.293N     P=0.445N     P=0.464N     P=0.457N     |
|POLY 3             |     P=0.216      P=0.314      P=0.683N     P=0.214     |P=0.347N     P=0.538N     P=0.552N     P=0.549N     |
|POLY 1.5           |     P=0.201      P=0.282      P=0.672N     P=0.189     |P=0.330N     P=0.523N     P=0.529N     P=0.527N     |
|POLY 6             |     P=0.236      P=0.363      P=0.701N     P=0.250     |P=0.374N     P=0.563N     P=0.589N     P=0.582N     |
|LOGISTIC REGRESSION|     P=0.208      P=0.276      P=0.614N     P=0.200     |P=0.293N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.180      P=0.243      P=0.661N     P=0.159     |P=0.311N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    8/50 (16%)   7/50 (14%)   6/50 (12%)  |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     7.6%         18.7%        16.7%        14.1%       |2.3%         0.0%         2.2%         4.5%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    4/24 (17%)   3/23 (13%)  |1/25 (4%)    0/33 (0%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     635          555          592          520         |734 (T)      ---          659          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.403      P=0.165      P=0.220      P=0.306     |P=0.256      P=0.445N     P=0.735N     P=0.560      |
|POLY 3             |     P=0.406      P=0.140      P=0.202      P=0.308     |P=0.252      P=0.538N     P=0.786N     P=0.537      |
|POLY 1.5           |     P=0.380      P=0.121      P=0.182      P=0.280     |P=0.248      P=0.523N     P=0.775N     P=0.519      |
|POLY 6             |     P=0.435      P=0.170      P=0.232      P=0.345     |P=0.260      P=0.563N     P=0.801N     P=0.568      |
|LOGISTIC REGRESSION|     P=0.359      P=0.113      P=0.171      P=0.265     |P=0.241      (e)          P=0.762      P=0.528      |
|COCH-ARM / FISHERS |     P=0.339      P=0.100      P=0.159      P=0.243     |P=0.241      P=0.500N     P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    9/50 (18%)   7/50 (14%)   7/50 (14%)  |2/50 (4%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     10.1%        21.0%        16.7%        16.3%       |4.6%         0.0%         4.5%         6.7%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    4/24 (17%)   3/23 (13%)  |2/25 (8%)    0/33 (0%)    0/30 (0%)    2/31 (7%)    |
|FIRST INCIDENCE    |     635          555          592          520         |734 (T)      ---          659          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426      P=0.198      P=0.337      P=0.331     |P=0.253      P=0.179N     P=0.648N     P=0.586      |
|POLY 3             |     P=0.436      P=0.161      P=0.318      P=0.336     |P=0.235      P=0.254N     P=0.710N     P=0.533      |
|POLY 1.5           |     P=0.406      P=0.141      P=0.293      P=0.305     |P=0.232      P=0.248N     P=0.703N     P=0.516      |
|POLY 6             |     P=0.468      P=0.193      P=0.354      P=0.376     |P=0.240      P=0.263N     P=0.719N     P=0.562      |
|LOGISTIC REGRESSION|     P=0.379      P=0.136      P=0.280      P=0.273     |P=0.229      (e)          P=0.694N     P=0.549      |
|COCH-ARM / FISHERS |     P=0.360      P=0.117      P=0.262      P=0.262     |P=0.228      P=0.247N     P=0.691N     P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    3/50 (6%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         9.5%         7.4%         14.2%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    2/24 (8%)    3/23 (13%)  |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     697          636          720          582         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.143      P=0.418      P=0.571      P=0.184     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.138      P=0.410      P=0.567      P=0.182     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.128      P=0.377      P=0.537      P=0.160     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.152      P=0.459      P=0.610      P=0.214     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.132      P=0.386      P=0.548      P=0.164     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.112      P=0.339      P=0.500      P=0.134     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   3/50 (6%)    7/50 (14%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         11.7%        7.4%         16.5%       |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    2/24 (8%)    3/23 (13%)  |1/25 (4%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     697          544          720          582         |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.108      P=0.289      P=0.571      P=0.122     |P=0.293N     P=0.445N     P=0.464N     P=0.457N     |
|POLY 3             |     P=0.101      P=0.282      P=0.567      P=0.114     |P=0.347N     P=0.538N     P=0.552N     P=0.549N     |
|POLY 1.5           |     P=0.093      P=0.252      P=0.537      P=0.098     |P=0.330N     P=0.523N     P=0.529N     P=0.527N     |
|POLY 6             |     P=0.113      P=0.328      P=0.610      P=0.138     |P=0.374N     P=0.563N     P=0.589N     P=0.582N     |
|LOGISTIC REGRESSION|     P=0.095      P=0.231      P=0.548      P=0.104     |P=0.293N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.082      P=0.218      P=0.500      P=0.080     |P=0.311N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    3/50 (6%)    7/50 (14%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         9.5%         7.4%         16.5%       |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    2/24 (8%)    3/23 (13%)  |1/25 (4%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     697          636          720          582         |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.078      P=0.418      P=0.571      P=0.122     |P=0.293N     P=0.445N     P=0.464N     P=0.457N     |
|POLY 3             |     P=0.072      P=0.410      P=0.567      P=0.114     |P=0.347N     P=0.538N     P=0.552N     P=0.549N     |
|POLY 1.5           |     P=0.066      P=0.377      P=0.537      P=0.098     |P=0.330N     P=0.523N     P=0.529N     P=0.527N     |
|POLY 6             |     P=0.080      P=0.459      P=0.610      P=0.138     |P=0.374N     P=0.563N     P=0.589N     P=0.582N     |
|LOGISTIC REGRESSION|     P=0.070      P=0.386      P=0.548      P=0.104     |P=0.293N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.058      P=0.339      P=0.500      P=0.080     |P=0.311N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  43/49 (88%)  40/50 (80%)  46/50 (92%) |                                                    |
|POLY-3 ADJUSTED (b)|     97.2%        91.8%        87.1%        94.2%       |                                                    |
|TERMINAL (d)       |     20/20 (100%) 21/23 (91%)  23/24 (96%)  22/23 (96%) |                                                    |
|FIRST INCIDENCE    |     445          548          457          502         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.305N     P=0.132N     P=0.055N     P=0.260N    |                                                    |
|POLY 3             |     P=0.400N     P=0.221N     P=0.041N*    P=0.411N    |                                                    |
|POLY 1.5           |     P=0.455N     P=0.273N     P=0.046N*    P=0.502N    |                                                    |
|POLY 6             |     P=0.388N     P=0.176N     P=0.058N     P=0.351N    |                                                    |
|LOGISTIC REGRESSION|     P=0.355N     P=0.154N     P=0.019N*    P=0.387N    |                                                    |
|COCH-ARM / FISHERS |     P=0.552      P=0.357N     P=0.074N     P=0.643N    |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    6/50 (12%)   3/50 (6%)   |2/50 (4%)    8/50 (16%)   5/50 (10%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     12.7%        2.4%         14.5%        7.1%        |4.6%         17.3%        11.3%        6.7%         |
|TERMINAL (d)       |     4/20 (20%)   1/23 (4%)    2/24 (8%)    1/23 (4%)   |2/25 (8%)    5/33 (15%)   5/30 (17%)   3/31 (10%)   |
|FIRST INCIDENCE    |     532          729 (T)      592          676         |734 (T)      678          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.447N     P=0.075N     P=0.599      P=0.292N    |P=0.374N     P=0.105      P=0.292      P=0.599      |
|POLY 3             |     P=0.488N     P=0.105N     P=0.567      P=0.351N    |P=0.446N     P=0.058      P=0.235      P=0.532      |
|POLY 1.5           |     P=0.490N     P=0.103N     P=0.537      P=0.351N    |P=0.449N     P=0.051      P=0.226      P=0.516      |
|POLY 6             |     P=0.489N     P=0.110N     P=0.611      P=0.356N    |P=0.435N     P=0.071      P=0.253      P=0.560      |
|LOGISTIC REGRESSION|     P=0.467N     P=0.085N     P=0.531      P=0.317N    |P=0.414N     P=0.068      P=0.292      P=0.599      |
|COCH-ARM / FISHERS |     P=0.497N     P=0.102N     P=0.500      P=0.357N    |P=0.449N     P=0.046 *    P=0.218      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.8%         0.0%         2.4%        |0.0%         0.0%         2.3%         4.5%         |
|TERMINAL (d)       |     0/20 (0%)    2/23 (9%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          648         |---          ---          734 (T)      668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.587      P=0.269      (e)          P=0.539     |P=0.075      (e)          P=0.536      P=0.269      |
|POLY 3             |     P=0.614      P=0.312      (e)          P=0.610     |P=0.075      (e)          P=0.556      P=0.272      |
|POLY 1.5           |     P=0.588      P=0.277      (e)          P=0.561     |P=0.072      (e)          P=0.530      P=0.255      |
|POLY 6             |     P=0.650      P=0.368      (e)          P=0.683     |P=0.080      (e)          P=0.598      P=0.301      |
|LOGISTIC REGRESSION|     P=0.570      P=0.269      (e)          P=0.484     |P=0.068      (e)          P=0.536      P=0.238      |
|COCH-ARM / FISHERS |     P=0.554      P=0.247      (e)          P=0.500     |P=0.068      (e)          P=0.500      P=0.247      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    6/50 (12%)   4/50 (8%)   |2/50 (4%)    8/50 (16%)   6/50 (12%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     12.7%        7.2%         14.5%        9.4%        |4.6%         17.3%        13.6%        11.2%        |
|TERMINAL (d)       |     4/20 (20%)   3/23 (13%)   2/24 (8%)    1/23 (4%)   |2/25 (8%)    5/33 (15%)   6/30 (20%)   4/31 (13%)   |
|FIRST INCIDENCE    |     532          729 (T)      592          648         |734 (T)      678          734 (T)      668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.480N     P=0.282N     P=0.599      P=0.419N    |P=0.453      P=0.105      P=0.194      P=0.299      |
|POLY 3             |     P=0.517N     P=0.358N     P=0.567      P=0.486N    |P=0.396      P=0.058      P=0.146      P=0.240      |
|POLY 1.5           |     P=0.526N     P=0.356N     P=0.537      P=0.490N    |P=0.385      P=0.051      P=0.140      P=0.228      |
|POLY 6             |     P=0.509N     P=0.364N     P=0.611      P=0.486N    |P=0.419      P=0.071      P=0.159      P=0.264      |
|LOGISTIC REGRESSION|     P=0.506N     P=0.300N     P=0.531      P=0.465N    |P=0.399      P=0.068      P=0.194      P=0.244      |
|COCH-ARM / FISHERS |     P=0.541N     P=0.357N     P=0.500      P=0.500N    |P=0.376      P=0.046 *    P=0.134      P=0.218      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.6%         2.2%         0.0%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |2/25 (8%)    1/33 (3%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.329N     P=0.403N     P=0.198N     P=0.425N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.386N     P=0.512N     P=0.266N     P=0.525N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.378N     P=0.509N     P=0.253N     P=0.514N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.399N     P=0.517N     P=0.286N     P=0.538N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.329N     P=0.403N     (e)          P=0.425N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.367N     P=0.500N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |7/50 (14%)   6/50 (12%)   6/50 (12%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|                                                        |15.7%        13.0%        13.3%        9.0%         |
|TERMINAL (d)       |                                                        |2/25 (8%)    4/33 (12%)   4/30 (13%)   3/31 (10%)   |
|FIRST INCIDENCE    |                                                        |635          636          528          731          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.176N     P=0.360N     P=0.428N     P=0.191N     |
|POLY 3             |                                                        |P=0.230N     P=0.484N     P=0.507N     P=0.274N     |
|POLY 1.5           |                                                        |P=0.225N     P=0.496N     P=0.504N     P=0.270N     |
|POLY 6             |                                                        |P=0.236N     P=0.466N     P=0.509N     P=0.278N     |
|LOGISTIC REGRESSION|                                                        |P=0.216N     P=0.498N     P=0.501N     P=0.250N     |
|COCH-ARM / FISHERS |                                                        |P=0.216N     P=0.500N     P=0.500N     P=0.262N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         7.0%         7.2%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     599          388          408          ---         |---          ---          655          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.248N     P=0.343      P=0.351      P=0.485N    |P=0.691      (e)          P=0.514      (e)          |
|POLY 3             |     P=0.264N     P=0.380      P=0.370      P=0.582N    |P=0.718      (e)          P=0.556      (e)          |
|POLY 1.5           |     P=0.265N     P=0.347      P=0.341      P=0.543N    |P=0.705      (e)          P=0.530      (e)          |
|POLY 6             |     P=0.270N     P=0.429      P=0.412      P=0.644N    |P=0.740      (e)          P=0.598      (e)          |
|LOGISTIC REGRESSION|     P=0.369N     P=0.211      P=0.268      P=0.564N    |P=0.687      (e)          P=0.508      (e)          |
|COCH-ARM / FISHERS |     P=0.272N     P=0.309      P=0.309      P=0.500N    |P=0.689      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/50 (64%)  33/50 (66%)  30/50 (60%)  31/50 (62%) |19/50 (38%)  19/50 (38%)  18/50 (36%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     73.7%        71.1%        65.4%        66.4%       |40.6%        40.1%        38.5%        27.8%        |
|TERMINAL (d)       |     15/20 (75%)  15/23 (65%)  12/24 (50%)  12/23 (52%) |7/25 (28%)   11/33 (33%)  9/30 (30%)   4/31 (13%)   |
|FIRST INCIDENCE    |     445          548          533          502         |519          627          528          562          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265N     P=0.357N     P=0.229N     P=0.285N    |P=0.089N     P=0.309N     P=0.378N     P=0.104N     |
|POLY 3             |     P=0.239N     P=0.494N     P=0.265N     P=0.299N    |P=0.099N     P=0.572N     P=0.510N     P=0.141N     |
|POLY 1.5           |     P=0.296N     P=0.572N     P=0.330N     P=0.378N    |P=0.100N     P=0.584      P=0.508N     P=0.144N     |
|POLY 6             |     P=0.190N     P=0.389N     P=0.191N     P=0.222N    |P=0.095N     P=0.544N     P=0.507N     P=0.133N     |
|LOGISTIC REGRESSION|     P=0.316N     P=0.533N     P=0.336N     P=0.368N    |P=0.099N     P=0.578      P=0.503N     P=0.144N     |
|COCH-ARM / FISHERS |     P=0.399N     P=0.500      P=0.418N     P=0.500N    |P=0.099N     P=0.582N     P=0.500N     P=0.142N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.7%         0.0%         2.4%         4.8%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   0/23 (0%)    0/24 (0%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     673          ---          667          683         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.528N     P=0.099N     P=0.265N     P=0.439N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.592N     P=0.136N     P=0.333N     P=0.511N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.580N     P=0.127N     P=0.320N     P=0.504N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.612N     P=0.152N     P=0.357N     P=0.530N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.545N     P=0.099N     P=0.283N     P=0.450N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.568N     P=0.121N     P=0.309N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  48/50 (96%)  48/50 (96%)  50/50 (100%)|43/50 (86%)  42/50 (84%)  48/50 (96%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     99.1%        98.1%        98.6%        100.0%      |89.1%        87.1%        96.6%        88.2%        |
|TERMINAL (d)       |     20/20 (100%) 23/23 (100%) 24/24 (100%) 23/23 (100%)|23/25 (92%)  28/33 (85%)  29/30 (97%)  29/31 (94%)  |
|FIRST INCIDENCE    |     445          388          457          502         |541          627          506          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.387N     P=0.235N     P=0.246N     P=0.348N    |P=0.264N     P=0.069N     P=0.530N     P=0.130N     |
|POLY 3             |     P=0.391      P=0.749N     P=0.903N     P=0.957     |P=0.512      P=0.506N     P=0.131      P=0.584N     |
|POLY 1.5           |     P=0.252      P=0.681N     P=0.781N     P=0.556     |P=0.545      P=0.538N     P=0.104      P=0.549N     |
|POLY 6             |     P=0.782      P=0.973N     P=1.000N     P=1.000     |P=0.462      P=0.429N     P=0.185      P=0.624N     |
|LOGISTIC REGRESSION|     P=0.368      P=0.544N     P=0.573N     P=0.753     |P=0.541      P=0.438N     P=0.074      P=0.511N     |
|COCH-ARM / FISHERS |     P=0.162      P=0.691N     P=0.691N     P=0.247     |P=0.551N     P=0.500N     P=0.080      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     40/50 (80%)  38/50 (76%)  37/50 (74%)  37/50 (74%) |26/50 (52%)  24/50 (48%)  26/50 (52%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|     87.6%        78.8%        78.1%        77.6%       |54.9%        49.6%        53.9%        38.5%        |
|TERMINAL (d)       |     17/20 (85%)  16/23 (70%)  16/24 (67%)  15/23 (65%) |10/25 (40%)  14/33 (42%)  13/30 (43%)  9/31 (29%)   |
|FIRST INCIDENCE    |     445          388          408          502         |519          217          525          562          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.204N     P=0.198N     P=0.175N     P=0.179N    |P=0.066N     P=0.169N     P=0.404N     P=0.052N     |
|POLY 3             |     P=0.175N     P=0.187N     P=0.162N     P=0.147N    |P=0.078N     P=0.378N     P=0.548N     P=0.081N     |
|POLY 1.5           |     P=0.212N     P=0.262N     P=0.215N     P=0.202N    |P=0.076N     P=0.398N     P=0.564N     P=0.081N     |
|POLY 6             |     P=0.152N     P=0.132N     P=0.124N     P=0.111N    |P=0.078N     P=0.350N     P=0.521N     P=0.078N     |
|LOGISTIC REGRESSION|     P=0.240N     P=0.316N     P=0.247N     P=0.197N    |P=0.069N     P=0.447N     P=0.574      P=0.080N     |
|COCH-ARM / FISHERS |     P=0.289N     P=0.405N     P=0.318N     P=0.318N    |P=0.070N     P=0.421N     P=0.579N     P=0.079N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  50/50 (100%) 50/50 (100%) 50/50 (100%)|48/50 (96%)  46/50 (92%)  49/50 (98%)  48/50 (96%)  |
|POLY-3 ADJUSTED (b)|     99.1%        100.0%       100.0%       100.0%      |96.0%        93.3%        98.0%        97.5%        |
|TERMINAL (d)       |     20/20 (100%) 23/23 (100%) 24/24 (100%) 23/23 (100%)|23/25 (92%)  30/33 (91%)  29/30 (97%)  30/31 (97%)  |
|FIRST INCIDENCE    |     445          388          408          502         |519          217          506          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.361N     P=0.325N     P=0.343N     P=0.348N    |P=0.322N     P=0.052N     P=0.305N     P=0.184N     |
|POLY 3             |     P=0.702      P=0.957      P=0.957      P=0.957     |P=0.306      P=0.443N     P=0.500      P=0.560      |
|POLY 1.5           |     P=0.284      P=0.556      P=0.556      P=0.556     |P=0.341      P=0.403N     P=0.500      P=0.611      |
|POLY 6             |     P=1.000      P=1.000      P=1.000      P=1.000     |P=0.284      P=0.478N     P=0.500      P=0.521      |
|LOGISTIC REGRESSION|     P=0.242      P=0.316      P=0.320      P=0.753     |P=0.421      P=0.334N     (e)          P=0.686      |
|COCH-ARM / FISHERS |     P=0.120      P=0.247      P=0.247      P=0.247     |P=0.420      P=0.339N     P=0.500      P=0.691N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).