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TDMS Study 05160-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97

EXPERIMENT: 05160 TEST: 05                                                                                     TIME: 15:09:06
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C
PATHOLOGIST: STEDHAM, M.                                                                                       CAS: 127-00-4
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97     
EXPERIMENT: 05160 TEST: 05                                                                                     TIME: 15:09:06     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C     
PATHOLOGIST: STEDHAM, M.                                                                                       CAS: 127-00-4      


SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF          1-CHLORO-2-PROPANOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Medulla                        Hyperplasia
Liver                                  Basophilic Focus
                                       Clear Cell Focus
Lung                                   Hemorrhage
Lymph Node, Mandibular                 Ectasia
Lymph Node, Mediastinal                Hyperplasia Lymphoid
Lymph Node: Renal                      Hemorrhage
Mammary Gland                          Hyperplasia
                                       Inflammation Chronic
Nose: Olfactory Epithelium             Inflammation Chronic
Nose: Respiratory Epithelium           Foreign Body
                                       Inflammation Chronic
Pancreas: Acinus                       Hyperplasia
Skin                                   Ulcer
Spleen                                 Fibrosis
Thymus                                 Atrophy
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Hyperplasia
Bone Marrow                            Atrophy
Bone Marrow: Myeloid Cell              Hyperplasia
Clitoral Gland                         Atrophy
Heart                                  Cardiomyopathy
Kidney                                 Nephropathy
Liver                                  Angiectasis
                                       Deformity
                                       Hepatodiaphragmatic Nodule
                                       Inflammation Granulomatous
Mammary Gland                          Dilatation
Nose: Olfactory Epithelium             Degeneration Hyaline
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
                                       Inflammation Chronic
Pancreas: Acinus                       Atrophy
Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Hematopoietic Cell Proliferation
Spleen: Capsule                        Fibrosis
Stomach, Forestomach                   Inflammation Chronic
Uterus                                 Hydrometra
===============================================================
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |7/49 (14%)   8/50 (16%)   9/50 (18%)   10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |16.0%        17.5%        20.3%        22.0%        |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |5/25 (20%)   7/33 (21%)   7/30 (23%)   8/31 (26%)   |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |597          728          714          449          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.705      (e)          P=0.536      (e)         |P=0.331      P=0.521N     P=0.526      P=0.438      |
|POLY 3             |     P=0.752      (e)          P=0.607      (e)         |P=0.260      P=0.548      P=0.413      P=0.334      |
|POLY 1.5           |     P=0.725      (e)          P=0.557      (e)         |P=0.259      P=0.529      P=0.410      P=0.324      |
|POLY 6             |     P=0.789      (e)          P=0.681      (e)         |P=0.266      P=0.578      P=0.422      P=0.353      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.536      (e)         |P=0.254      P=0.568      P=0.424      P=0.314      |
|COCH-ARM / FISHERS |     P=0.689      (e)          P=0.495      (e)         |P=0.253      P=0.517      P=0.410      P=0.314      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Cytoplasmic Alteration                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    2/49 (4%)    0/50 (0%)   |5/49 (10%)   3/50 (6%)    1/50 (2%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.8%         4.9%         0.0%        |11.5%        6.6%         2.3%         8.9%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    1/24 (4%)    0/23 (0%)   |3/25 (12%)   3/33 (9%)    1/30 (3%)    3/31 (10%)   |
|FIRST INCIDENCE    |     ---          555          408          ---         |653          734 (T)      734 (T)      562          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.466N     P=0.263      P=0.262      (e)         |P=0.387N     P=0.232N     P=0.076N     P=0.401N     |
|POLY 3             |     P=0.482N     P=0.309      P=0.307      (e)         |P=0.445N     P=0.342N     P=0.106N     P=0.492N     |
|POLY 1.5           |     P=0.482N     P=0.273      P=0.273      (e)         |P=0.440N     P=0.347N     P=0.102N     P=0.491N     |
|POLY 6             |     P=0.489N     P=0.366      P=0.363      (e)         |P=0.451N     P=0.334N     P=0.111N     P=0.490N     |
|LOGISTIC REGRESSION|     P=0.562N     P=0.214      P=0.181      (e)         |P=0.434N     P=0.291N     P=0.093N     P=0.485N     |
|COCH-ARM / FISHERS |     P=0.488N     P=0.242      P=0.242      (e)         |P=0.435N     P=0.346N     P=0.098N     P=0.487N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    0/49 (0%)    1/50 (2%)   |2/49 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.4%         0.0%         2.4%        |4.5%         6.5%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     729 (T)      711          ---          697         |519          677          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.596N     P=0.719N     P=0.464N     P=0.733N    |P=0.068N     P=0.556      P=0.239N     P=0.242N     |
|POLY 3             |     P=0.634N     P=0.800N     P=0.594N     P=0.796N    |P=0.072N     P=0.541      P=0.264N     P=0.261N     |
|POLY 1.5           |     P=0.622N     P=0.784N     P=0.552N     P=0.779N    |P=0.069N     P=0.524      P=0.250N     P=0.249N     |
|POLY 6             |     P=0.655N     P=0.824N     P=0.658N     P=0.825N    |P=0.074N     P=0.570      P=0.285N     P=0.278N     |
|LOGISTIC REGRESSION|     P=0.593N     P=0.731N     (e)          P=0.737N    |P=0.066N     P=0.543      P=0.164N     P=0.143N     |
|COCH-ARM / FISHERS |     P=0.611N     P=0.747      P=0.505N     P=0.753N    |P=0.067N     P=0.510      P=0.242N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    3/49 (6%)    0/50 (0%)   |4/49 (8%)    5/50 (10%)   7/50 (14%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         7.4%         0.0%        |9.2%         10.8%        15.6%        17.8%        |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    2/24 (8%)    0/23 (0%)   |1/25 (4%)    2/33 (6%)    4/30 (13%)   3/31 (10%)   |
|FIRST INCIDENCE    |     ---          ---          603          ---         |646          636          659          693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.555      (e)          P=0.150      (e)         |P=0.163      P=0.617      P=0.338      P=0.269      |
|POLY 3             |     P=0.593      (e)          P=0.159      (e)         |P=0.125      P=0.552      P=0.287      P=0.201      |
|POLY 1.5           |     P=0.567      (e)          P=0.138      (e)         |P=0.125      P=0.531      P=0.280      P=0.193      |
|POLY 6             |     P=0.626      (e)          P=0.194      (e)         |P=0.128      P=0.586      P=0.302      P=0.217      |
|LOGISTIC REGRESSION|     P=0.540      (e)          P=0.124      (e)         |P=0.124      P=0.510      P=0.274      P=0.193      |
|COCH-ARM / FISHERS |     P=0.531      (e)          P=0.117      (e)         |P=0.125      P=0.513      P=0.274      P=0.188      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  8/49 (16%)   8/49 (16%)   4/50 (8%)   |5/49 (10%)   0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     24.9%        18.9%        19.6%        9.5%        |11.4%        0.0%         2.3%         4.5%         |
|TERMINAL (d)       |     4/20 (20%)   4/23 (17%)   6/24 (25%)   2/23 (9%)   |2/25 (8%)    0/33 (0%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     551          544          592          569         |635          ---          734 (T)      731          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.046N*    P=0.297N     P=0.286N     P=0.056N    |P=0.217N     P=0.023N*    P=0.086N     P=0.167N     |
|POLY 3             |     P=0.052N     P=0.365N     P=0.403N     P=0.062N    |P=0.253N     P=0.030N*    P=0.109N     P=0.223N     |
|POLY 1.5           |     P=0.055N     P=0.386N     P=0.406N     P=0.065N    |P=0.245N     P=0.030N*    P=0.104N     P=0.218N     |
|POLY 6             |     P=0.053N     P=0.343N     P=0.405N     P=0.061N    |P=0.265N     P=0.030N*    P=0.116N     P=0.230N     |
|LOGISTIC REGRESSION|     P=0.050N     P=0.370N     P=0.352N     P=0.057N    |P=0.240N     P=0.031N*    P=0.099N     P=0.209N     |
|COCH-ARM / FISHERS |     P=0.062N     P=0.416N     P=0.416N     P=0.074N    |P=0.240N     P=0.027N*    P=0.098N     P=0.210N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Hyperostosis                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |6/50 (12%)   7/50 (14%)   7/50 (14%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.4%         0.0%         2.4%        |13.5%        15.1%        15.5%        8.9%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |2/25 (8%)    4/33 (12%)   3/30 (10%)   2/31 (7%)    |
|FIRST INCIDENCE    |     616          630          ---          520         |635          627          506          698          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.589N     P=0.736N     P=0.489N     P=0.742N    |P=0.236N     P=0.581N     P=0.574      P=0.294N     |
|POLY 3             |     P=0.634N     P=0.796N     P=0.593N     P=0.793N    |P=0.283N     P=0.543      P=0.527      P=0.380N     |
|POLY 1.5           |     P=0.623N     P=0.780N     P=0.550N     P=0.777N    |P=0.281N     P=0.519      P=0.514      P=0.377N     |
|POLY 6             |     P=0.654N     P=0.821N     P=0.658N     P=0.820N    |P=0.282N     P=0.580      P=0.549      P=0.379N     |
|LOGISTIC REGRESSION|     P=0.620      P=0.738      P=0.520N     P=0.664     |P=0.276N     P=0.509      P=0.499      P=0.363N     |
|COCH-ARM / FISHERS |     P=0.612N     P=0.753N     P=0.500N     P=0.753N    |P=0.276N     P=0.500      P=0.500      P=0.370N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/47 (9%)    0/45 (0%)    1/47 (2%)    3/49 (6%)   |0/47 (0%)    0/50 (0%)    0/47 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     10.2%        0.0%         2.6%         7.1%        |0.0%         0.0%         0.0%         4.5%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     502          ---          653          520         |---          ---          ---          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.580N     P=0.058N     P=0.172N     P=0.459N    |P=0.049 *    (e)          (e)          P=0.261      |
|POLY 3             |     P=0.595N     P=0.077N     P=0.204N     P=0.486N    |P=0.051      (e)          (e)          P=0.280      |
|POLY 1.5           |     P=0.590N     P=0.072N     P=0.192N     P=0.479N    |P=0.049 *    (e)          (e)          P=0.264      |
|POLY 6             |     P=0.606N     P=0.086N     P=0.225N     P=0.503N    |P=0.055      (e)          (e)          P=0.307      |
|LOGISTIC REGRESSION|     P=0.450      P=0.092N     P=0.227N     P=0.617     |P=0.037 *    (e)          (e)          P=0.279      |
|COCH-ARM / FISHERS |     P=0.585N     P=0.064N     P=0.181N     P=0.476N    |P=0.047 *    (e)          (e)          P=0.258      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/45 (0%)    2/47 (4%)    0/49 (0%)   |0/47 (0%)    0/50 (0%)    0/47 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.1%         0.0%        |0.0%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          667          ---         |---          ---          ---          691          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.610      (e)          P=0.268      (e)         |P=0.205      (e)          (e)          P=0.527      |
|POLY 3             |     P=0.652      (e)          P=0.304      (e)         |P=0.221      (e)          (e)          P=0.560      |
|POLY 1.5           |     P=0.630      (e)          P=0.273      (e)         |P=0.211      (e)          (e)          P=0.536      |
|POLY 6             |     P=0.680      (e)          P=0.352      (e)         |P=0.236      (e)          (e)          P=0.597      |
|LOGISTIC REGRESSION|     P=0.604      (e)          P=0.245      (e)         |P=0.198      (e)          (e)          P=0.508      |
|COCH-ARM / FISHERS |     P=0.598      (e)          P=0.247      (e)         |P=0.199      (e)          (e)          P=0.510      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/47 (4%)    4/45 (9%)    2/47 (4%)    1/49 (2%)   |1/47 (2%)    3/50 (6%)    0/47 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     5.3%         10.1%        5.1%         2.4%        |2.4%         6.5%         0.0%         2.3%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |0/25 (0%)    2/33 (6%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     585          544          408          648         |719          691          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.234N     P=0.395      P=0.659N     P=0.453N    |P=0.360N     P=0.381      P=0.494N     P=0.726N     |
|POLY 3             |     P=0.234N     P=0.387      P=0.716N     P=0.522N    |P=0.396N     P=0.362      P=0.547N     P=0.775N     |
|POLY 1.5           |     P=0.232N     P=0.356      P=0.704N     P=0.503N    |P=0.393N     P=0.345      P=0.526N     P=0.765N     |
|POLY 6             |     P=0.242N     P=0.431      P=0.738N     P=0.554N    |P=0.398N     P=0.390      P=0.579N     P=0.789N     |
|LOGISTIC REGRESSION|     P=0.301N     P=0.262      P=0.653      P=0.514N    |P=0.381N     P=0.347      P=0.495N     P=0.739N     |
|COCH-ARM / FISHERS |     P=0.235N     P=0.318      P=0.692N     P=0.484N    |P=0.388N     P=0.332      P=0.500N     P=0.742N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow: Myeloid Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    1/45 (2%)    0/47 (0%)    0/49 (0%)   |3/47 (6%)    0/50 (0%)    0/47 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |7.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |2/25 (8%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          388          ---          ---         |727          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.549N     P=0.504      (e)          (e)         |P=0.042N*    P=0.082N     P=0.097N     P=0.090N     |
|POLY 3             |     P=0.581N     P=0.593      (e)          (e)         |P=0.054N     P=0.114N     P=0.131N     P=0.122N     |
|POLY 1.5           |     P=0.562N     P=0.548      (e)          (e)         |P=0.050N     P=0.113N     P=0.126N     P=0.118N     |
|POLY 6             |     P=0.615N     P=0.657      (e)          (e)         |P=0.059N     P=0.117N     P=0.139N     P=0.128N     |
|LOGISTIC REGRESSION|     P=0.872      P=0.350      (e)          (e)         |P=0.044N*    P=0.089N     P=0.103N     P=0.094N     |
|COCH-ARM / FISHERS |     P=0.542N     P=0.489      (e)          (e)         |P=0.050N     P=0.110N     P=0.121N     P=0.113N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone: Femur                                                                                                                      |
|     Hyperostosis                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |1/25 (4%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |629          ---          694          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.187N     P=0.205N     P=0.475N     P=0.216N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.213N     P=0.255N     P=0.529N     P=0.264N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.205N     P=0.248N     P=0.516N     P=0.252N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.226N     P=0.264N     P=0.546N     P=0.281N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.196N     P=0.236N     P=0.499N     P=0.236N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.196N     P=0.247N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    4/50 (8%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.6%         4.8%         2.4%         9.5%        |4.5%         4.4%         6.7%         4.5%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    1/33 (3%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     637          723          533          682         |519          677          663          693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.134      P=0.549      P=0.738N     P=0.229     |P=0.578      P=0.638N     P=0.510      P=0.676N     |
|POLY 3             |     P=0.133      P=0.577      P=0.801N     P=0.232     |P=0.573      P=0.702N     P=0.522      P=0.713N     |
|POLY 1.5           |     P=0.125      P=0.543      P=0.782N     P=0.208     |P=0.569      P=0.701N     P=0.510      P=0.704      |
|POLY 6             |     P=0.146      P=0.626      P=0.830N     P=0.268     |P=0.583      P=0.704N     P=0.544      P=0.722N     |
|LOGISTIC REGRESSION|     P=0.116      P=0.527      P=0.729      P=0.197     |P=0.564      P=0.675N     P=0.525      P=0.671N     |
|COCH-ARM / FISHERS |     P=0.113      P=0.500      P=0.753N     P=0.181     |P=0.566      P=0.691N     P=0.500      P=0.691N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/49 (0%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         0.0%         4.6%         |
|TERMINAL (d)       |                                                        |0/25 (0%)    0/32 (0%)    0/29 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |                                                        |---          ---          ---          693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.048 *    (e)          (e)          P=0.261      |
|POLY 3             |                                                        |P=0.050      (e)          (e)          P=0.272      |
|POLY 1.5           |                                                        |P=0.048 *    (e)          (e)          P=0.255      |
|POLY 6             |                                                        |P=0.054      (e)          (e)          P=0.302      |
|LOGISTIC REGRESSION|                                                        |P=0.046 *    (e)          (e)          P=0.238      |
|COCH-ARM / FISHERS |                                                        |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/49 (8%)    4/49 (8%)    5/49 (10%)   6/49 (12%)   |
|POLY-3 ADJUSTED (b)|                                                        |9.3%         8.9%         11.5%        13.8%        |
|TERMINAL (d)       |                                                        |4/25 (16%)   3/32 (9%)    2/29 (7%)    6/31 (19%)   |
|FIRST INCIDENCE    |                                                        |734 (T)      699          708          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.342      P=0.509N     P=0.582      P=0.510      |
|POLY 3             |                                                        |P=0.275      P=0.635N     P=0.527      P=0.396      |
|POLY 1.5           |                                                        |P=0.272      P=0.642N     P=0.513      P=0.382      |
|POLY 6             |                                                        |P=0.282      P=0.622N     P=0.554      P=0.424      |
|LOGISTIC REGRESSION|                                                        |P=0.295      P=0.557N     P=0.538      P=0.510      |
|COCH-ARM / FISHERS |                                                        |P=0.269      P=0.643N     P=0.500      P=0.370      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/49 (6%)    0/49 (0%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |7.0%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |                                                        |3/25 (12%)   0/32 (0%)    0/29 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      ---          721          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.076N     P=0.080N     P=0.259N     P=0.085N     |
|POLY 3             |                                                        |P=0.101N     P=0.125N     P=0.327N     P=0.132N     |
|POLY 1.5           |                                                        |P=0.095N     P=0.123N     P=0.318N     P=0.126N     |
|POLY 6             |                                                        |P=0.109N     P=0.127N     P=0.339N     P=0.139N     |
|LOGISTIC REGRESSION|                                                        |P=0.081N     (e)          P=0.274N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.092N     P=0.121N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     0/0 (0%)     2/2 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         100.0%      |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          605         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.205      (e)          (e)          (e)         |(e)          (e)            (e)       (e)           |
|POLY 3             |     P=1.000N     (e)          (e)          (e)         |(e)          (e)            (e)       (e)           |
|POLY 1.5           |     P=1.000N     (e)          (e)          (e)         |(e)          (e)            (e)       (e)          | 
|POLY 6             |     P=1.000N     (e)          (e)          (e)         |(e)          (e)            (e)       (e)           |
|LOGISTIC REGRESSION|     P=0.280      (e)          (e)          (e)         |(e)          (e)            (e)       (e)           |
|COCH-ARM /FISHERS |      P=0.187      (e)          (e)          (e)         |(e)          (e)            (e)       (e)           |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     35/50 (70%)  41/50 (82%)  42/50 (84%)  33/50 (66%) |18/50 (36%)  21/50 (42%)  15/50 (30%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     74.3%        85.6%        88.4%        71.1%       |39.4%        44.5%        32.5%        24.4%        |
|TERMINAL (d)       |     12/20 (60%)  18/23 (78%)  21/24 (88%)  17/23 (74%) |10/25 (40%)  12/33 (36%)  6/30 (20%)   8/31 (26%)   |
|FIRST INCIDENCE    |     362          502          533          520         |541          627          528          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.173N     P=0.497      P=0.420      P=0.238N    |P=0.025N*    P=0.494N     P=0.231N     P=0.042N*    |
|POLY 3             |     P=0.274N     P=0.125      P=0.058      P=0.460N    |P=0.035N*    P=0.392      P=0.326N     P=0.095N     |
|POLY 1.5           |     P=0.246N     P=0.119      P=0.062      P=0.434N    |P=0.034N*    P=0.358      P=0.333N     P=0.096N     |
|POLY 6             |     P=0.342N     P=0.138      P=0.060      P=0.517N    |P=0.035N*    P=0.456      P=0.305N     P=0.091N     |
|LOGISTIC REGRESSION|     P=0.194N     P=0.131      P=0.086      P=0.397N    |P=0.032N*    P=0.370      P=0.334N     P=0.084N     |
|COCH-ARM / FISHERS |     P=0.236N     P=0.121      P=0.077      P=0.415N    |P=0.033N*    P=0.341      P=0.335N     P=0.093N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     579          ---          ---          648         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.449N     P=0.224N     P=0.234N     P=0.463N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.507N     P=0.279N     P=0.288N     P=0.533N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.490N     P=0.259N     P=0.264N     P=0.516N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.534N     P=0.314N     P=0.329N     P=0.564N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.529N     P=0.280N     P=0.269N     P=0.592N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.470N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    6/50 (12%)   4/50 (8%)   |4/50 (8%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     7.6%         0.0%         14.5%        9.4%        |9.0%         4.3%         6.7%         6.7%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    3/24 (13%)   1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     658          ---          648          520         |635          627          571          693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.236      P=0.099N     P=0.310      P=0.563     |P=0.485N     P=0.295N     P=0.483N     P=0.437N     |
|POLY 3             |     P=0.223      P=0.136N     P=0.294      P=0.577     |P=0.522N     P=0.332N     P=0.510N     P=0.513N     |
|POLY 1.5           |     P=0.210      P=0.128N     P=0.271      P=0.545     |P=0.514N     P=0.337N     P=0.506N     P=0.509N     |
|POLY 6             |     P=0.238      P=0.153N     P=0.329      P=0.618     |P=0.529N     P=0.323N     P=0.514N     P=0.516N     |
|LOGISTIC REGRESSION|     P=0.207      P=0.110N     P=0.267      P=0.516     |P=0.508N     P=0.330N     P=0.495N     P=0.500N     |
|COCH-ARM / FISHERS |     P=0.193      P=0.121N     P=0.243      P=0.500     |P=0.506N     P=0.339N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/46 (2%)    3/46 (7%)    1/48 (2%)    2/47 (4%)   |3/47 (6%)    2/49 (4%)    2/49 (4%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|     2.8%         7.8%         2.5%         5.1%        |7.2%         4.5%         4.6%         2.3%         |
|TERMINAL (d)       |     1/20 (5%)    1/23 (4%)    0/24 (0%)    2/23 (9%)   |1/25 (4%)    2/33 (6%)    2/30 (7%)    1/31 (3%)    |
|FIRST INCIDENCE    |     729 (T)      555          571          729 (T)     |712          734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.570      P=0.357      P=0.735N     P=0.549     |P=0.194N     P=0.397N     P=0.430N     P=0.246N     |
|POLY 3             |     P=0.599      P=0.381      P=0.791N     P=0.591     |P=0.238N     P=0.487N     P=0.502N     P=0.314N     |
|POLY 1.5           |     P=0.577      P=0.346      P=0.773N     P=0.554     |P=0.235N     P=0.487N     P=0.493N     P=0.308N     |
|POLY 6             |     P=0.628      P=0.433      P=0.820N     P=0.642     |P=0.242N     P=0.486N     P=0.514N     P=0.322N     |
|LOGISTIC REGRESSION|     P=0.556      P=0.318      P=0.762N     P=0.549     |P=0.207N     P=0.428N     P=0.458N     P=0.270N     |
|COCH-ARM / FISHERS |     P=0.547      P=0.308      P=0.742N     P=0.508     |P=0.229N     P=0.480N     P=0.480N     P=0.301N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/45 (7%)    3/47 (6%)    3/46 (7%)    2/47 (4%)   |6/49 (12%)   4/49 (8%)    3/48 (6%)    7/49 (14%)   |
|POLY-3 ADJUSTED (b)|     8.4%         7.5%         8.0%         5.0%        |14.0%        8.9%         7.0%         15.9%        |
|TERMINAL (d)       |     3/20 (15%)   2/23 (9%)    2/24 (8%)    2/23 (9%)   |6/25 (24%)   4/33 (12%)   3/30 (10%)   6/31 (19%)   |
|FIRST INCIDENCE    |     729 (T)      388          686          729 (T)     |734 (T)      734 (T)      734 (T)      722          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.348N     P=0.608N     P=0.586N     P=0.435N    |P=0.457      P=0.204N     P=0.153N     P=0.578N     |
|POLY 3             |     P=0.375N     P=0.648N     P=0.677N     P=0.493N    |P=0.379      P=0.357N     P=0.259N     P=0.535      |
|POLY 1.5           |     P=0.376N     P=0.642N     P=0.665N     P=0.484N    |P=0.375      P=0.367N     P=0.257N     P=0.517      |
|POLY 6             |     P=0.380N     P=0.662N     P=0.697N     P=0.512N    |P=0.387      P=0.340N     P=0.260N     P=0.569      |
|LOGISTIC REGRESSION|     P=0.359N     P=0.642N     P=0.632N     P=0.435N    |P=0.449      P=0.204N     P=0.153N     P=0.611N     |
|COCH-ARM / FISHERS |     P=0.380N     P=0.641N     P=0.651N     P=0.479N    |P=0.370      P=0.370N     P=0.254N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/49 (0%)    2/49 (4%)    3/50 (6%)   |1/46 (2%)    0/49 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     7.7%         0.0%         4.9%         7.2%        |2.5%         0.0%         0.0%         4.5%         |
|TERMINAL (d)       |     2/20 (10%)   0/23 (0%)    1/24 (4%)    3/23 (13%)  |1/25 (4%)    0/33 (0%)    0/30 (0%)    2/31 (7%)    |
|FIRST INCIDENCE    |     703          ---          653          729 (T)     |734 (T)      ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.432      P=0.095N     P=0.435N     P=0.600N    |P=0.264      P=0.445N     P=0.464N     P=0.575      |
|POLY 3             |     P=0.417      P=0.138N     P=0.528N     P=0.669N    |P=0.265      P=0.525N     P=0.536N     P=0.560      |
|POLY 1.5           |     P=0.407      P=0.130N     P=0.518N     P=0.663N    |P=0.261      P=0.510N     P=0.512N     P=0.545      |
|POLY 6             |     P=0.431      P=0.152N     P=0.545N     P=0.685N    |P=0.272      P=0.549N     P=0.571N     P=0.584      |
|LOGISTIC REGRESSION|     P=0.423      P=0.094N     P=0.467N     P=0.607N    |P=0.264      (e)          (e)          P=0.575      |
|COCH-ARM / FISHERS |     P=0.392      P=0.125N     P=0.510N     P=0.661N    |P=0.254      P=0.484N     P=0.479N     P=0.532      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    0/49 (0%)    1/50 (2%)   |24/46 (52%)  28/49 (57%)  26/50 (52%)  30/50 (60%)  |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         2.4%        |55.8%        58.8%        55.7%        65.1%        |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |16/25 (64%)  18/33 (55%)  19/30 (63%)  23/31 (74%)  |
|FIRST INCIDENCE    |     579          ---          ---          648         |519          217          525          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.449N     P=0.224N     P=0.234N     P=0.463N    |P=0.364      P=0.440N     P=0.475N     P=0.481      |
|POLY 3             |     P=0.507N     P=0.282N     P=0.290N     P=0.533N    |P=0.224      P=0.472      P=0.590N     P=0.244      |
|POLY 1.5           |     P=0.489N     P=0.263N     P=0.267N     P=0.516N    |P=0.252      P=0.432      P=0.585N     P=0.260      |
|POLY 6             |     P=0.534N     P=0.314N     P=0.329N     P=0.564N    |P=0.188      P=0.538      P=0.593N     P=0.227      |
|LOGISTIC REGRESSION|     P=0.529N     P=0.286N     P=0.276N     P=0.592N    |P=0.285      P=0.388      P=0.580N     P=0.286      |
|COCH-ARM / FISHERS |     P=0.469N     P=0.253N     P=0.253N     P=0.500N    |P=0.292      P=0.390      P=0.574N     P=0.286      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  46/49 (94%)  46/49 (94%)  49/50 (98%) |23/46 (50%)  23/49 (47%)  15/50 (30%)  20/50 (40%)  |
|POLY-3 ADJUSTED (b)|     95.1%        97.1%        95.8%        98.9%       |53.8%        50.8%        33.6%        43.9%        |
|TERMINAL (d)       |     20/20 (100%) 23/23 (100%) 23/24 (96%)  23/23 (100%)|13/25 (52%)  19/33 (58%)  10/30 (33%)  16/31 (52%)  |
|FIRST INCIDENCE    |     445          502          408          502         |541          682          694          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.455N     P=0.239N     P=0.254N     P=0.408N    |P=0.117N     P=0.207N     P=0.036N*    P=0.141N     |
|POLY 3             |     P=0.213      P=0.528      P=0.655      P=0.284     |P=0.148N     P=0.480N     P=0.043N*    P=0.239N     |
|POLY 1.5           |     P=0.182      P=0.521      P=0.606      P=0.239     |P=0.142N     P=0.484N     P=0.039N*    P=0.232N     |
|POLY 6             |     P=0.251      P=0.554      P=0.706      P=0.345     |P=0.153N     P=0.470N     P=0.048N*    P=0.243N     |
|LOGISTIC REGRESSION|     P=0.226      P=0.662N     P=0.586      P=0.291     |P=0.137N     P=0.369N     P=0.034N*    P=0.207N     |
|COCH-ARM / FISHERS |     P=0.136      P=0.511      P=0.511      P=0.181     |P=0.137N     P=0.463N     P=0.036N*    P=0.218N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/49 (6%)    4/49 (8%)    3/50 (6%)   |2/46 (4%)    2/49 (4%)    4/50 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     10.2%        7.2%         9.7%         7.1%        |4.8%         4.4%         9.0%         2.2%         |
|TERMINAL (d)       |     3/20 (15%)   0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    1/33 (3%)    2/30 (7%)    0/31 (0%)    |
|FIRST INCIDENCE    |     673          630          627          683         |635          678          659          691          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.409N     P=0.422N     P=0.572N     P=0.435N    |P=0.410N     P=0.622N     P=0.377      P=0.479N     |
|POLY 3             |     P=0.450N     P=0.500N     P=0.645N     P=0.494N    |P=0.420N     P=0.681N     P=0.391      P=0.499N     |
|POLY 1.5           |     P=0.453N     P=0.504N     P=0.648N     P=0.494N    |P=0.412N     P=0.679N     P=0.384      P=0.487N     |
|POLY 6             |     P=0.452N     P=0.496N     P=0.640N     P=0.501N    |P=0.429N     P=0.684N     P=0.404      P=0.516N     |
|LOGISTIC REGRESSION|     P=0.454N     P=0.469N     P=0.640N     P=0.445N    |P=0.400N     P=0.668N     P=0.379      P=0.457N     |
|COCH-ARM / FISHERS |     P=0.463N     P=0.511N     P=0.631      P=0.500N    |P=0.401N     P=0.667N     P=0.379      P=0.468N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   11/50 (22%)  7/50 (14%)   9/50 (18%)  |1/50 (2%)    5/50 (10%)   3/50 (6%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     12.8%        25.9%        17.2%        21.4%       |2.3%         10.9%        6.8%         15.6%        |
|TERMINAL (d)       |     4/20 (20%)   8/23 (35%)   6/24 (25%)   6/23 (26%)  |1/25 (4%)    4/33 (12%)   3/30 (10%)   5/31 (16%)   |
|FIRST INCIDENCE    |     693          613          710          682         |734 (T)      678          734 (T)      639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.393      P=0.140      P=0.503      P=0.270     |P=0.057      P=0.174      P=0.371      P=0.058      |
|POLY 3             |     P=0.376      P=0.123      P=0.440      P=0.255     |P=0.044 *    P=0.122      P=0.333      P=0.036 *    |
|POLY 1.5           |     P=0.350      P=0.105      P=0.414      P=0.228     |P=0.042 *    P=0.111      P=0.320      P=0.033 *    |
|POLY 6             |     P=0.406      P=0.155      P=0.479      P=0.293     |P=0.048 *    P=0.142      P=0.357      P=0.042 *    |
|LOGISTIC REGRESSION|     P=0.378      P=0.129      P=0.461      P=0.261     |P=0.043 *    P=0.131      P=0.371      P=0.037 *    |
|COCH-ARM / FISHERS |     P=0.313      P=0.086      P=0.380      P=0.194     |P=0.041 *    P=0.102      P=0.309      P=0.030 *    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |29/50 (58%)  33/50 (66%)  27/50 (54%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|     7.6%         0.0%         0.0%         0.0%        |63.9%        69.9%        59.5%        68.9%        |
|TERMINAL (d)       |     2/20 (10%)   0/23 (0%)    0/24 (0%)    0/23 (0%)   |22/25 (88%)  26/33 (79%)  22/30 (73%)  26/31 (84%)  |
|FIRST INCIDENCE    |     551          ---          ---          ---         |609          484          525          449          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.044N*    P=0.104N     P=0.098N     P=0.103N    |P=0.364N     P=0.297N     P=0.126N     P=0.362N     |
|POLY 3             |     P=0.060N     P=0.137N     P=0.143N     P=0.136N    |P=0.442      P=0.350      P=0.418N     P=0.389      |
|POLY 1.5           |     P=0.054N     P=0.128N     P=0.131N     P=0.127N    |P=0.435      P=0.298      P=0.422N     P=0.364      |
|POLY 6             |     P=0.070N     P=0.153N     P=0.164N     P=0.154N    |P=0.460      P=0.448      P=0.402N     P=0.442      |
|LOGISTIC REGRESSION|     P=0.051N     P=0.118N     P=0.119N     P=0.118N    |P=0.420      P=0.456      P=0.359N     P=0.392      |
|COCH-ARM / FISHERS |     P=0.051N     P=0.121N     P=0.121N     P=0.121N    |P=0.422      P=0.268      P=0.420N     P=0.341      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   8/50 (16%)   7/50 (14%)   3/50 (6%)   |3/50 (6%)    7/50 (14%)   7/50 (14%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     18.0%        19.2%        17.2%        7.2%        |6.8%         15.3%        15.8%        4.5%         |
|TERMINAL (d)       |     7/20 (35%)   8/23 (35%)   7/24 (29%)   3/23 (13%)  |3/25 (12%)   7/33 (21%)   7/30 (23%)   2/31 (7%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.049N*    P=0.619N     P=0.465N     P=0.093N    |P=0.209N     P=0.286      P=0.234      P=0.401N     |
|POLY 3             |     P=0.080N     P=0.587      P=0.609N     P=0.144N    |P=0.286N     P=0.185      P=0.171      P=0.516N     |
|POLY 1.5           |     P=0.088N     P=0.549      P=0.609N     P=0.149N    |P=0.289N     P=0.170      P=0.164      P=0.510N     |
|POLY 6             |     P=0.074N     P=0.640      P=0.613N     P=0.143N    |P=0.277N     P=0.212      P=0.185      P=0.523N     |
|LOGISTIC REGRESSION|     P=0.049N*    P=0.619N     P=0.465N     P=0.093N    |P=0.209N     P=0.286      P=0.234      P=0.401N     |
|COCH-ARM / FISHERS |     P=0.101N     P=0.500      P=0.613N     P=0.159N    |P=0.290N     P=0.159      P=0.159      P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     362          ---          ---          ---         |---          676          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.120N     P=0.237N     P=0.240N     P=0.235N    |P=0.379N     P=0.293      (e)          (e)          |
|POLY 3             |     P=0.142N     P=0.281N     P=0.290N     P=0.280N    |P=0.396N     P=0.275      (e)          (e)          |
|POLY 1.5           |     P=0.131N     P=0.260N     P=0.265N     P=0.259N    |P=0.392N     P=0.257      (e)          (e)          |
|POLY 6             |     P=0.162N     P=0.315N     P=0.330N     P=0.316N    |P=0.399N     P=0.307      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.242N     P=0.316N     P=0.320N     P=0.753N    |P=0.385N     P=0.239      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.120N     P=0.247N     P=0.247N     P=0.247N    |P=0.384N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Deformity                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |3/50 (6%)    6/50 (12%)   3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         4.8%         2.4%         0.0%        |6.8%         13.0%        6.7%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |2/25 (8%)    3/33 (9%)    2/30 (7%)    0/31 (0%)    |
|FIRST INCIDENCE    |     729 (T)      716          667          ---         |722          677          525          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.216N     P=0.560      P=0.729N     P=0.472N    |P=0.040N*    P=0.374      P=0.599N     P=0.090N     |
|POLY 3             |     P=0.245N     P=0.581      P=0.804N     P=0.583N    |P=0.048N*    P=0.282      P=0.672N     P=0.131N     |
|POLY 1.5           |     P=0.242N     P=0.545      P=0.784N     P=0.543N    |P=0.049N*    P=0.261      P=0.668N     P=0.126N     |
|POLY 6             |     P=0.254N     P=0.634      P=0.833N     P=0.646N    |P=0.047N*    P=0.319      P=0.677N     P=0.139N     |
|LOGISTIC REGRESSION|     P=0.222N     P=0.559      P=0.750N     (e)         |P=0.050N     P=0.271      P=0.663      P=0.099N     |
|COCH-ARM / FISHERS |     P=0.241N     P=0.500      P=0.753N     P=0.500N    |P=0.050N     P=0.243      P=0.661N     P=0.121N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  8/50 (16%)   12/50 (24%)  12/50 (24%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     30.3%        19.0%        29.4%        28.1%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     8/20 (40%)   6/23 (26%)   11/24 (46%)  6/23 (26%)  |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     579          643          695          582         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.505      P=0.132N     P=0.409N     P=0.458N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.464      P=0.190N     P=0.587N     P=0.530N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.438      P=0.205N     P=0.586N     P=0.554N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.495      P=0.174N     P=0.595N     P=0.505N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.489      P=0.133N     P=0.486N     P=0.470N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.399      P=0.227N     P=0.592N     P=0.592N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  10/50 (20%)  3/50 (6%)   |6/50 (12%)   3/50 (6%)    7/50 (14%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     10.1%        23.8%        24.6%        7.2%        |13.6%        6.6%         15.8%        8.9%         |
|TERMINAL (d)       |     3/20 (15%)   8/23 (35%)   10/24 (42%)  3/23 (13%)  |4/25 (16%)   3/33 (9%)    6/30 (20%)   3/31 (10%)   |
|FIRST INCIDENCE    |     532          630          729 (T)      729 (T)     |641          734 (T)      697          649          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.181N     P=0.115      P=0.119      P=0.430N    |P=0.369N     P=0.139N     P=0.616N     P=0.268N     |
|POLY 3             |     P=0.225N     P=0.098      P=0.087      P=0.506N    |P=0.454N     P=0.236N     P=0.519      P=0.375N     |
|POLY 1.5           |     P=0.238N     P=0.086      P=0.081      P=0.500N    |P=0.451N     P=0.242N     P=0.509      P=0.374N     |
|POLY 6             |     P=0.215N     P=0.117      P=0.097      P=0.521N    |P=0.455N     P=0.226N     P=0.539      P=0.370N     |
|LOGISTIC REGRESSION|     P=0.204N     P=0.106      P=0.095      P=0.450N    |P=0.431N     P=0.188N     P=0.535      P=0.350N     |
|COCH-ARM / FISHERS |     P=0.266N     P=0.074      P=0.074      P=0.500N    |P=0.447N     P=0.243N     P=0.500      P=0.370N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.7%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          555          ---          ---         |659          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.366N     P=0.263      (e)          (e)         |P=0.121N     P=0.204N     P=0.234N     P=0.231N     |
|POLY 3             |     P=0.395N     P=0.313      (e)          (e)         |P=0.134N     P=0.255N     P=0.267N     P=0.264N     |
|POLY 1.5           |     P=0.388N     P=0.278      (e)          (e)         |P=0.126N     P=0.249N     P=0.254N     P=0.252N     |
|POLY 6             |     P=0.412N     P=0.371      (e)          (e)         |P=0.146N     P=0.265N     P=0.288N     P=0.282N     |
|LOGISTIC REGRESSION|     P=0.403N     P=0.220      (e)          (e)         |P=0.120N     P=0.228N     P=0.231N     P=0.229N     |
|COCH-ARM / FISHERS |     P=0.384N     P=0.247      (e)          (e)         |P=0.120N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    5/50 (10%)   0/50 (0%)   |2/50 (4%)    3/50 (6%)    12/50 (24%)  4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     5.1%         7.2%         11.9%        0.0%        |4.6%         6.6%         26.3%        8.8%         |
|TERMINAL (d)       |     0/20 (0%)    2/23 (9%)    3/24 (13%)   0/23 (0%)   |2/25 (8%)    3/33 (9%)    7/30 (23%)   0/31 (0%)    |
|FIRST INCIDENCE    |     693          721          408          ---         |734 (T)      734 (T)      525          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.195N     P=0.562      P=0.270      P=0.226N    |P=0.251      P=0.627      P=0.012 *    P=0.392      |
|POLY 3             |     P=0.203N     P=0.574      P=0.276      P=0.277N    |P=0.220      P=0.541      P=0.005 **   P=0.375      |
|POLY 1.5           |     P=0.208N     P=0.541      P=0.250      P=0.257N    |P=0.207      P=0.520      P=0.004 **   P=0.356      |
|POLY 6             |     P=0.203N     P=0.620      P=0.314      P=0.314N    |P=0.245      P=0.575      P=0.006 **   P=0.408      |
|LOGISTIC REGRESSION|     P=0.214N     P=0.569      P=0.210      P=0.213N    |P=0.200      P=0.627      P=0.005 **   P=0.338      |
|COCH-ARM / FISHERS |     P=0.220N     P=0.500      P=0.218      P=0.247N    |P=0.200      P=0.500      P=0.004 **   P=0.339      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |12/50 (24%)  5/50 (10%)   9/50 (18%)   11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |27.1%        10.9%        20.2%        24.3%        |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |8/25 (32%)   5/33 (15%)   8/30 (27%)   9/31 (29%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |641          734 (T)      655          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.538      P=0.016N*    P=0.185N     P=0.309N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.430      P=0.046N*    P=0.316N     P=0.488N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.429      P=0.051N     P=0.316N     P=0.495N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.434      P=0.039N*    P=0.312N     P=0.475N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.438      P=0.026N*    P=0.268N     P=0.463N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.424      P=0.054N     P=0.312N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   2/50 (4%)    5/50 (10%)  |4/50 (8%)    8/50 (16%)   5/50 (10%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     15.2%        14.4%        4.9%         11.9%       |8.9%         17.4%        11.3%        13.4%        |
|TERMINAL (d)       |     5/20 (25%)   6/23 (26%)   2/24 (8%)    4/23 (17%)  |1/25 (4%)    7/33 (21%)   5/30 (17%)   5/31 (16%)   |
|FIRST INCIDENCE    |     551          729 (T)      729 (T)      676         |597          677          734 (T)      708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.276N     P=0.527N     P=0.082N     P=0.402N    |P=0.543      P=0.305      P=0.576      P=0.461      |
|POLY 3             |     P=0.339N     P=0.612N     P=0.140N     P=0.486N    |P=0.464      P=0.197      P=0.509      P=0.382      |
|POLY 1.5           |     P=0.343N     P=0.614N     P=0.136N     P=0.489N    |P=0.464      P=0.186      P=0.504      P=0.375      |
|POLY 6             |     P=0.338N     P=0.613N     P=0.147N     P=0.489N    |P=0.472      P=0.219      P=0.521      P=0.399      |
|LOGISTIC REGRESSION|     P=0.297N     P=0.527N     P=0.109N     P=0.424N    |P=0.472      P=0.181      P=0.501      P=0.371      |
|COCH-ARM / FISHERS |     P=0.352N     P=0.620N     P=0.134N     P=0.500N    |P=0.466      P=0.178      P=0.500      P=0.370      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    5/50 (10%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         4.8%        |6.7%         4.3%         11.0%        2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      683         |519          676          506          668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.076      (e)          P=0.536      P=0.266     |P=0.311N     P=0.451N     P=0.397      P=0.298N     |
|POLY 3             |     P=0.085      (e)          P=0.611      P=0.313     |P=0.339N     P=0.505N     P=0.380      P=0.326N     |
|POLY 1.5           |     P=0.077      (e)          P=0.561      P=0.278     |P=0.333N     P=0.506N     P=0.369      P=0.318N     |
|POLY 6             |     P=0.097      (e)          P=0.685      P=0.368     |P=0.344N     P=0.502N     P=0.401      P=0.336N     |
|LOGISTIC REGRESSION|     P=0.074      (e)          P=0.536      P=0.260     |P=0.323N     P=0.474N     P=0.384      P=0.266N     |
|COCH-ARM / FISHERS |     P=0.068      (e)          P=0.500      P=0.247     |P=0.324N     P=0.500N     P=0.357      P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    4/50 (8%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         9.6%         2.4%        |2.3%         4.4%         6.8%         6.7%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    2/24 (8%)    1/23 (4%)   |0/25 (0%)    1/33 (3%)    2/30 (7%)    2/31 (7%)    |
|FIRST INCIDENCE    |     611          ---          457          729 (T)     |720          676          733          733          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.555N     P=0.214N     P=0.390      P=0.459N    |P=0.271      P=0.574      P=0.366      P=0.381      |
|POLY 3             |     P=0.598N     P=0.278N     P=0.403      P=0.534N    |P=0.237      P=0.543      P=0.332      P=0.335      |
|POLY 1.5           |     P=0.592N     P=0.258N     P=0.374      P=0.516N    |P=0.233      P=0.522      P=0.319      P=0.320      |
|POLY 6             |     P=0.612N     P=0.313N     P=0.445      P=0.566N    |P=0.246      P=0.577      P=0.356      P=0.361      |
|LOGISTIC REGRESSION|     P=0.602N     P=0.235N     P=0.324      P=0.478N    |P=0.237      P=0.508      P=0.336      P=0.347      |
|COCH-ARM / FISHERS |     P=0.590N     P=0.247N     P=0.339      P=0.500N    |P=0.227      P=0.500      P=0.309      P=0.309      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         4.8%         7.4%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    3/24 (13%)   0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     579          592          729 (T)      ---         |709          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.305N     P=0.538      P=0.355      P=0.491N    |P=0.307N     P=0.477N     P=0.488N     P=0.488N     |
|POLY 3             |     P=0.332N     P=0.577      P=0.363      P=0.582N    |P=0.347N     P=0.538N     P=0.552N     P=0.549N     |
|POLY 1.5           |     P=0.330N     P=0.543      P=0.337      P=0.543N    |P=0.330N     P=0.523N     P=0.529N     P=0.527N     |
|POLY 6             |     P=0.341N     P=0.626      P=0.404      P=0.644N    |P=0.373N     P=0.563N     P=0.588N     P=0.581N     |
|LOGISTIC REGRESSION|     P=0.326N     P=0.467      P=0.321      P=0.588N    |P=0.311N     P=0.496N     P=0.498N     P=0.497N     |
|COCH-ARM / FISHERS |     P=0.334N     P=0.500      P=0.309      P=0.500N    |P=0.311N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         4.7%         2.4%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     693          544          408          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.510N     P=0.541      P=0.754N     P=0.741N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.529N     P=0.584      P=0.799N     P=0.798N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.524N     P=0.547      P=0.781N     P=0.780N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.542N     P=0.637      P=0.828N     P=0.827N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.619N     P=0.451      P=0.714      P=0.738N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.523N     P=0.500      P=0.753N     P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         2.5%         9.5%        |2.3%         0.0%         4.5%         4.4%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          706          729 (T)      630         |672          ---          659          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.022 *    P=0.551      P=0.536      P=0.085     |P=0.242      P=0.462N     P=0.527      P=0.517      |
|POLY 3             |     P=0.022 *    P=0.611      P=0.611      P=0.089     |P=0.250      P=0.538N     P=0.534      P=0.537      |
|POLY 1.5           |     P=0.020 *    P=0.561      P=0.561      P=0.076     |P=0.245      P=0.523N     P=0.518      P=0.519      |
|POLY 6             |     P=0.026 *    P=0.683      P=0.685      P=0.112     |P=0.259      P=0.563N     P=0.561      P=0.566      |
|LOGISTIC REGRESSION|     P=0.020 *    P=0.521      P=0.536      P=0.071     |P=0.236      P=0.496N     P=0.500      P=0.510      |
|COCH-ARM / FISHERS |     P=0.018 *    P=0.500      P=0.500      P=0.059     |P=0.238      P=0.500N     P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         7.3%         2.4%        |6.7%         0.0%         2.3%         4.5%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |1/25 (4%)    0/33 (0%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     ---          ---          641          648         |629          ---          734 (T)      668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.280      (e)          P=0.148      P=0.539     |P=0.547N     P=0.101N     P=0.278N     P=0.455N     |
|POLY 3             |     P=0.286      (e)          P=0.163      P=0.610     |P=0.587N     P=0.126N     P=0.331N     P=0.519N     |
|POLY 1.5           |     P=0.266      (e)          P=0.142      P=0.561     |P=0.578N     P=0.124N     P=0.320N     P=0.512N     |
|POLY 6             |     P=0.315      (e)          P=0.199      P=0.683     |P=0.600N     P=0.130N     P=0.346N     P=0.526N     |
|LOGISTIC REGRESSION|     P=0.236      (e)          P=0.122      P=0.484     |P=0.568N     P=0.114N     P=0.304N     P=0.499N     |
|COCH-ARM / FISHERS |     P=0.241      (e)          P=0.121      P=0.500     |P=0.568N     P=0.121N     P=0.309N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    6/50 (12%)   1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.1%        2.4%         14.6%        2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   1/23 (4%)    4/24 (17%)   1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     551          729 (T)      648          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.235N     P=0.149N     P=0.459      P=0.146N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.279N     P=0.191N     P=0.424      P=0.189N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.278N     P=0.184N     P=0.400      P=0.183N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.287N     P=0.203N     P=0.460      P=0.205N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.258N     P=0.167N     P=0.398      P=0.166N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.285N     P=0.181N     P=0.370      P=0.181N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.3%         0.0%         6.8%         4.5%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |1/25 (4%)    0/33 (0%)    3/30 (10%)   2/31 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      ---          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.268      P=0.445N     P=0.371      P=0.575      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.242      P=0.538N     P=0.333      P=0.536      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.238      P=0.523N     P=0.320      P=0.519      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.250      P=0.563N     P=0.357      P=0.567      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.268      (e)          P=0.371      P=0.575      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.233      P=0.500N     P=0.309      P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node                                                                                                                       |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/24 (4%)    1/23 (4%)    0/23 (0%)    1/24 (4%)   |1/11 (9%)    2/9 (22%)    1/15 (7%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     5.1%         5.6%         0.0%         5.0%        |11.5%        24.1%        8.6%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/6 (0%)     0/9 (0%)     0/6 (0%)    |0/3 (0%)     1/3 (33%)    1/4 (25%)    0/0 (0%)     |
|FIRST INCIDENCE    |     709          657          ---          672         |680          627          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.582N     P=0.726N     P=0.469N     P=0.727N    |P=0.370N     P=0.525      P=0.722N     P=0.479N     |
|POLY 3             |     P=0.635N     P=0.799      P=0.593N     P=0.805N    |P=0.314N     P=0.525      P=0.766N     P=0.684N     |
|POLY 1.5           |     P=0.622N     P=0.777      P=0.553N     P=0.784N    |P=0.297N     P=0.479      P=0.731N     P=0.636N     |
|POLY 6             |     P=0.661N     P=0.835      P=0.659N     P=0.840N    |P=0.359N     P=0.598      P=0.824N     P=0.774N     |
|LOGISTIC REGRESSION|     P=0.606N     P=0.745      P=0.499N     P=0.763N    |P=0.284N     P=0.408      P=0.695N     P=0.588N     |
|COCH-ARM / FISHERS |     P=0.610N     P=0.745      P=0.511N     P=0.755N    |P=0.282N     P=0.421      P=0.677N     P=0.611N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    8/50 (16%)   2/50 (4%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         18.8%        4.9%         7.2%        |2.3%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    4/23 (17%)   2/24 (8%)    2/23 (9%)   |1/25 (4%)    0/33 (0%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     729 (T)      611          729 (T)      676         |734 (T)      ---          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.450N     P=0.033 *    P=0.564      P=0.361     |P=0.385N     P=0.445N     P=0.721N     P=0.457N     |
|POLY 3             |     P=0.470N     P=0.026 *    P=0.576      P=0.379     |P=0.444N     P=0.538N     P=0.788N     P=0.554N     |
|POLY 1.5           |     P=0.485N     P=0.021 *    P=0.542      P=0.346     |P=0.432N     P=0.523N     P=0.776N     P=0.532N     |
|POLY 6             |     P=0.455N     P=0.036 *    P=0.627      P=0.428     |P=0.462N     P=0.563N     P=0.805N     P=0.586N     |
|LOGISTIC REGRESSION|     P=0.470N     P=0.024 *    P=0.564      P=0.348     |P=0.385N     (e)          P=0.721N     (e)          |
|COCH-ARM / FISHERS |     P=0.511N     P=0.015 *    P=0.500      P=0.309     |P=0.417N     P=0.500N     P=0.753N     P=0.505N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |6/50 (12%)   4/50 (8%)    4/50 (8%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     7.6%         2.4%         7.3%         4.8%        |13.3%        8.6%         9.0%         4.5%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |2/25 (8%)    1/33 (3%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     578          711          573          697         |597          627          663          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.505N     P=0.261N     P=0.613N     P=0.462N    |P=0.104N     P=0.272N     P=0.328N     P=0.115N     |
|POLY 3             |     P=0.536N     P=0.327N     P=0.681N     P=0.515N    |P=0.125N     P=0.361N     P=0.390N     P=0.150N     |
|POLY 1.5           |     P=0.532N     P=0.316N     P=0.671N     P=0.506N    |P=0.121N     P=0.369N     P=0.382N     P=0.147N     |
|POLY 6             |     P=0.546N     P=0.347N     P=0.698N     P=0.535N    |P=0.130N     P=0.347N     P=0.398N     P=0.153N     |
|LOGISTIC REGRESSION|     P=0.519N     P=0.295N     P=0.658N     P=0.483N    |P=0.115N     P=0.366N     P=0.368N     P=0.136N     |
|COCH-ARM / FISHERS |     P=0.532N     P=0.309N     P=0.661N     P=0.500N    |P=0.116N     P=0.370N     P=0.370N     P=0.141N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    5/50 (10%)   2/50 (4%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     5.0%         9.5%         11.9%        4.8%        |2.3%         0.0%         9.0%         2.3%         |
|TERMINAL (d)       |     0/20 (0%)    2/23 (9%)    3/24 (13%)   2/23 (9%)   |0/25 (0%)    0/33 (0%)    2/30 (7%)    0/31 (0%)    |
|FIRST INCIDENCE    |     529          643          408          729 (T)     |597          ---          655          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.467N     P=0.399      P=0.267      P=0.660N    |P=0.449      P=0.496N     P=0.216      P=0.755      |
|POLY 3             |     P=0.507N     P=0.394      P=0.262      P=0.719N    |P=0.438      P=0.538N     P=0.196      P=0.786      |
|POLY 1.5           |     P=0.507N     P=0.369      P=0.242      P=0.706N    |P=0.432      P=0.523N     P=0.187      P=0.772      |
|POLY 6             |     P=0.514N     P=0.432      P=0.291      P=0.743N    |P=0.451      P=0.562N     P=0.212      P=0.799N     |
|LOGISTIC REGRESSION|     P=0.539N     P=0.312      P=0.169      P=0.649     |P=0.422      P=0.449N     P=0.179      P=0.697N     |
|COCH-ARM / FISHERS |     P=0.515N     P=0.339      P=0.218      P=0.691N    |P=0.424      P=0.500N     P=0.181      P=0.747      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     12.5%        4.8%         7.1%         4.8%        |2.3%         0.0%         4.4%         0.0%         |
|TERMINAL (d)       |     3/20 (15%)   0/23 (0%)    1/24 (4%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     532          655          408          676         |722          ---          525          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188N     P=0.179N     P=0.297N     P=0.176N    |P=0.464N     P=0.468N     P=0.516      P=0.474N     |
|POLY 3             |     P=0.219N     P=0.219N     P=0.359N     P=0.220N    |P=0.498N     P=0.538N     P=0.539      P=0.554N     |
|POLY 1.5           |     P=0.216N     P=0.217N     P=0.356N     P=0.217N    |P=0.488N     P=0.523N     P=0.520      P=0.532N     |
|POLY 6             |     P=0.225N     P=0.223N     P=0.369N     P=0.229N    |P=0.512N     P=0.563N     P=0.569      P=0.586N     |
|LOGISTIC REGRESSION|     P=0.250N     P=0.227N     P=0.398N     P=0.221N    |P=0.484N     P=0.480N     P=0.530      P=0.493N     |
|COCH-ARM / FISHERS |     P=0.216N     P=0.218N     P=0.357N     P=0.218N    |P=0.475N     P=0.500N     P=0.500      P=0.505N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  11/50 (22%)  8/50 (16%)   11/50 (22%) |4/50 (8%)    2/50 (4%)    7/50 (14%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     26.4%        24.7%        19.3%        25.0%       |9.0%         4.4%         15.3%        2.2%         |
|TERMINAL (d)       |     4/20 (20%)   2/23 (9%)    3/24 (13%)   1/23 (4%)   |1/25 (4%)    1/33 (3%)    2/30 (7%)    0/31 (0%)    |
|FIRST INCIDENCE    |     445          555          639          564         |635          678          571          691          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.424N     P=0.470N     P=0.224N     P=0.480N    |P=0.249N     P=0.261N     P=0.315      P=0.158N     |
|POLY 3             |     P=0.484N     P=0.543N     P=0.321N     P=0.552N    |P=0.276N     P=0.340N     P=0.286      P=0.192N     |
|POLY 1.5           |     P=0.492N     P=0.565N     P=0.313N     P=0.568N    |P=0.270N     P=0.342N     P=0.274      P=0.187N     |
|POLY 6             |     P=0.476N     P=0.513N     P=0.335N     P=0.535N    |P=0.281N     P=0.336N     P=0.308      P=0.198N     |
|LOGISTIC REGRESSION|     P=0.528N     P=0.548      P=0.294N     P=0.557     |P=0.265N     P=0.338N     P=0.263      P=0.177N     |
|COCH-ARM / FISHERS |     P=0.509N     P=0.595N     P=0.306N     P=0.595N    |P=0.264N     P=0.339N     P=0.262      P=0.181N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.5%         4.8%         0.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     532          592          ---          ---         |---          ---          525          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.035N*    P=0.439N     P=0.112N     P=0.106N    |P=0.687      (e)          P=0.500      (e)          |
|POLY 3             |     P=0.042N*    P=0.515N     P=0.144N     P=0.137N    |P=0.718      (e)          P=0.556      (e)          |
|POLY 1.5           |     P=0.040N*    P=0.507N     P=0.132N     P=0.127N    |P=0.705      (e)          P=0.530      (e)          |
|POLY 6             |     P=0.046N*    P=0.531N     P=0.166N     P=0.156N    |P=0.740      (e)          P=0.597      (e)          |
|LOGISTIC REGRESSION|     P=0.043N*    P=0.528N     P=0.129N     P=0.138N    |P=0.673      (e)          P=0.662      (e)          |
|COCH-ARM / FISHERS |     P=0.039N*    P=0.500N     P=0.121N     P=0.121N    |P=0.689      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    5/50 (10%)   0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.7%         4.7%         2.5%         0.0%        |4.5%         0.0%         11.0%        0.0%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |1/25 (4%)    0/33 (0%)    2/30 (7%)    0/31 (0%)    |
|FIRST INCIDENCE    |     673          609          729 (T)      ---         |582          ---          571          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.055N     P=0.431N     P=0.270N     P=0.105N    |P=0.372N     P=0.209N     P=0.258      P=0.221N     |
|POLY 3             |     P=0.065N     P=0.510N     P=0.337N     P=0.135N    |P=0.404N     P=0.255N     P=0.239      P=0.264N     |
|POLY 1.5           |     P=0.063N     P=0.504N     P=0.321N     P=0.127N    |P=0.395N     P=0.249N     P=0.228      P=0.253N     |
|POLY 6             |     P=0.070N     P=0.522N     P=0.365N     P=0.154N    |P=0.413N     P=0.265N     P=0.260      P=0.281N     |
|LOGISTIC REGRESSION|     P=0.057N     P=0.483N     P=0.278N     P=0.105N    |P=0.389N     P=0.223N     P=0.221      P=0.225N     |
|COCH-ARM / FISHERS |     P=0.062N     P=0.500N     P=0.309N     P=0.121N    |P=0.387N     P=0.247N     P=0.218      P=0.247N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |646          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.216N     P=0.230N     P=0.224N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.135N     P=0.255N     P=0.273N     P=0.264N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.128N     P=0.248N     P=0.259N     P=0.252N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.148N     P=0.265N     P=0.294N     P=0.281N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.121N     P=0.236N     P=0.240N     P=0.237N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.121N     P=0.247N     P=0.253N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.7%         2.4%         4.9%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   1/23 (4%)    1/24 (4%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     611          729 (T)      639          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.248N     P=0.260N     P=0.435N     P=0.262N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.291N     P=0.321N     P=0.519N     P=0.320N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.285N     P=0.309N     P=0.505N     P=0.308N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.304N     P=0.342N     P=0.542N     P=0.344N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.262N     P=0.270N     P=0.476N     P=0.270N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.280N     P=0.301N     P=0.490N     P=0.301N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    4/50 (8%)    4/50 (8%)    6/50 (12%)  |7/50 (14%)   3/50 (6%)    6/49 (12%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     10.0%        9.4%         9.7%         14.0%       |15.4%        6.5%         13.7%        11.1%        |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    1/24 (4%)    2/23 (9%)   |1/25 (4%)    2/33 (6%)    2/30 (7%)    2/31 (7%)    |
|FIRST INCIDENCE    |     362          611          641          605         |635          627          663          668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330      P=0.574N     P=0.574N     P=0.440     |P=0.428N     P=0.108N     P=0.447N     P=0.323N     |
|POLY 3             |     P=0.316      P=0.640N     P=0.660N     P=0.439     |P=0.485N     P=0.158N     P=0.542N     P=0.396N     |
|POLY 1.5           |     P=0.304      P=0.637N     P=0.647N     P=0.414     |P=0.476N     P=0.161N     P=0.531N     P=0.390N     |
|POLY 6             |     P=0.332      P=0.645N     P=0.677N     P=0.476     |P=0.493N     P=0.155N     P=0.555N     P=0.400N     |
|LOGISTIC REGRESSION|     P=0.268      P=0.598      P=0.631      P=0.309     |P=0.466N     P=0.157N     P=0.515N     P=0.379N     |
|COCH-ARM / FISHERS |     P=0.287      P=0.631N     P=0.631N     P=0.383     |P=0.466N     P=0.159N     P=0.516N     P=0.380N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    3/50 (6%)    4/49 (8%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         6.6%         9.1%         4.5%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    3/33 (9%)    3/30 (10%)   2/31 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          734 (T)      525          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.352      P=0.173      P=0.083      P=0.286      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.324      P=0.141      P=0.068      P=0.271      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.315      P=0.130      P=0.063      P=0.255      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.342      P=0.162      P=0.078      P=0.300      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.308      P=0.173      P=0.061      P=0.286      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.307      P=0.121      P=0.056      P=0.247      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.2%        4.8%         0.0%         4.7%        |0.0%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   2/23 (9%)    0/24 (0%)    1/23 (4%)   |0/25 (0%)    1/33 (3%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     551          729 (T)      ---          582         |---          734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.204N     P=0.285N     P=0.052N     P=0.289N    |P=0.533N     P=0.555      (e)          (e)          |
|POLY 3             |     P=0.238N     P=0.344N     P=0.070N     P=0.336N    |P=0.578N     P=0.555      (e)          (e)          |
|POLY 1.5           |     P=0.233N     P=0.336N     P=0.064N     P=0.330N    |P=0.567N     P=0.530      (e)          (e)          |
|POLY 6             |     P=0.248N     P=0.361N     P=0.081N     P=0.352N    |P=0.592N     P=0.597      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.227N     P=0.315N     P=0.062N     P=0.350N    |(e)          P=0.555      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.228N     P=0.329N     P=0.056N     P=0.329N    |P=0.552N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/24 (4%)    1/23 (4%)    0/23 (0%)    0/24 (0%)   |2/11 (18%)   1/9 (11%)    0/15 (0%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     5.0%         5.5%         0.0%         0.0%        |22.2%        12.0%        0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/6 (0%)     0/9 (0%)     0/6 (0%)    |0/3 (0%)     0/3 (0%)     0/4 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     445          555          ---          ---         |659          627          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.224N     P=0.750N     P=0.496N     P=0.492N    |P=0.101N     P=0.459N     P=0.229N     P=0.226N     |
|POLY 3             |     P=0.267N     P=0.789      P=0.592N     P=0.588N    |P=0.130N     P=0.566N     P=0.220N     P=0.406N     |
|POLY 1.5           |     P=0.250N     P=0.770      P=0.552N     P=0.546N    |P=0.116N     P=0.566N     P=0.189N     P=0.369N     |
|POLY 6             |     P=0.299N     P=0.821      P=0.656N     P=0.661N    |P=0.161N     P=0.576N     P=0.284N     P=0.493N     |
|LOGISTIC REGRESSION|     P=0.458N     P=0.637      (e)          (e)         |P=0.103N     P=0.708N     P=0.165N     P=0.337N     |
|COCH-ARM / FISHERS |     P=0.230N     P=0.745      P=0.511N     P=0.500N    |P=0.104N     P=0.579N     P=0.169N     P=0.359N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Pancreatic                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/24 (4%)    4/23 (17%)   2/23 (9%)    5/24 (21%)  |2/11 (18%)   0/9 (0%)     2/15 (13%)   1/7 (14%)    |
|POLY-3 ADJUSTED (b)|     5.2%         21.8%        10.3%        24.5%       |22.2%        0.0%         17.0%        17.3%        |
|TERMINAL (d)       |     1/8 (13%)    0/6 (0%)     0/9 (0%)     0/6 (0%)    |0/3 (0%)     0/3 (0%)     1/4 (25%)    0/0 (0%)     |
|FIRST INCIDENCE    |     729 (T)      630          606          672         |659          ---          694          698          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.144      P=0.211      P=0.542      P=0.127     |P=0.619N     P=0.211N     P=0.652N     P=0.476N     |
|POLY 3             |     P=0.133      P=0.178      P=0.551      P=0.116     |P=0.637      P=0.297N     P=0.654N     P=0.711N     |
|POLY 1.5           |     P=0.124      P=0.168      P=0.520      P=0.105     |P=0.630      P=0.284N     P=0.619N     P=0.684N     |
|POLY 6             |     P=0.150      P=0.198      P=0.601      P=0.139     |P=0.653      P=0.329N     P=0.712N     P=0.766N     |
|LOGISTIC REGRESSION|     P=0.120      P=0.139      P=0.488      P=0.095     |P=0.621      P=0.300N     P=0.584N     P=0.660N     |
|COCH-ARM / FISHERS |     P=0.114      P=0.160      P=0.484      P=0.094     |P=0.625      P=0.289N     P=0.574N     P=0.674N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/24 (0%)    3/23 (13%)   0/23 (0%)    0/24 (0%)   |0/11 (0%)    0/9 (0%)     0/15 (0%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         17.0%        0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     2/6 (33%)    0/9 (0%)     0/6 (0%)    |0/3 (0%)     0/3 (0%)     0/4 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          711          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.303N     P=0.097      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.316N     P=0.124      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.297N     P=0.115      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.353N     P=0.144      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.284N     P=0.083      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.287N     P=0.109      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/24 (13%)   3/23 (13%)   1/23 (4%)    8/24 (33%)  |3/11 (27%)   2/9 (22%)    4/15 (27%)   1/7 (14%)    |
|POLY-3 ADJUSTED (b)|     14.8%        16.5%        5.3%         38.4%       |33.4%        23.5%        33.0%        17.3%        |
|TERMINAL (d)       |     1/8 (13%)    1/6 (17%)    1/9 (11%)    4/6 (67%)   |1/3 (33%)    0/3 (0%)     0/4 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     445          555          729 (T)      520         |659          627          663          691          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.029 *    P=0.654      P=0.283N     P=0.074     |P=0.323N     P=0.452N     P=0.564      P=0.470N     |
|POLY 3             |     P=0.033 *    P=0.653      P=0.363N     P=0.089     |P=0.444N     P=0.555N     P=0.710N     P=0.518N     |
|POLY 1.5           |     P=0.032 *    P=0.648      P=0.341N     P=0.086     |P=0.422N     P=0.573N     P=0.684N     P=0.494N     |
|POLY 6             |     P=0.035 *    P=0.666      P=0.399N     P=0.096     |P=0.494N     P=0.538N     P=0.746N     P=0.576N     |
|LOGISTIC REGRESSION|     P=0.034 *    P=0.669N     P=0.333N     P=0.082     |P=0.401N     P=0.654N     P=0.664N     P=0.454N     |
|COCH-ARM / FISHERS |     P=0.034 *    P=0.646      P=0.321N     P=0.084     |P=0.399N     P=0.604N     P=0.655N     P=0.485N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/24 (13%)   4/23 (17%)   2/23 (9%)    7/24 (29%)  |1/11 (9%)    2/9 (22%)    1/15 (7%)    1/7 (14%)    |
|POLY-3 ADJUSTED (b)|     15.3%        22.3%        10.4%        34.4%       |11.8%        24.1%        8.5%         17.3%        |
|TERMINAL (d)       |     2/8 (25%)    3/6 (50%)    1/9 (11%)    4/6 (67%)   |1/3 (33%)    0/3 (0%)     0/4 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     693          609          639          585         |734 (T)      678          668          693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.072      P=0.403      P=0.454N     P=0.096     |P=0.597N     P=0.539      P=0.729N     P=0.522      |
|POLY 3             |     P=0.117      P=0.493      P=0.545N     P=0.167     |P=0.650N     P=0.537      P=0.758N     P=0.741      |
|POLY 1.5           |     P=0.111      P=0.486      P=0.532N     P=0.156     |P=0.639N     P=0.484      P=0.726N     P=0.701      |
|POLY 6             |     P=0.125      P=0.509      P=0.568N     P=0.183     |P=0.677N     P=0.630      P=0.810N     P=0.807      |
|LOGISTIC REGRESSION|     P=0.114      P=0.399      P=0.504N     P=0.135     |P=0.639N     P=0.497      P=0.696N     P=0.650      |
|COCH-ARM / FISHERS |     P=0.103      P=0.475      P=0.521N     P=0.143     |P=0.633N     P=0.421      P=0.677N     P=0.641      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   13/45 (29%)  9/48 (19%)   6/47 (13%)  |34/50 (68%)  33/50 (66%)  25/49 (51%)  27/50 (54%)  |
|POLY-3 ADJUSTED (b)|     19.3%        32.9%        22.2%        14.7%       |69.1%        69.1%        54.9%        57.0%        |
|TERMINAL (d)       |     2/20 (10%)   7/23 (30%)   5/24 (21%)   2/23 (9%)   |14/25 (56%)  21/33 (64%)  17/30 (57%)  18/31 (58%)  |
|FIRST INCIDENCE    |     502          502          571          569         |519          636          597          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.141N     P=0.269      P=0.582      P=0.316N    |P=0.044N*    P=0.155N     P=0.040N*    P=0.059N     |
|POLY 3             |     P=0.173N     P=0.132      P=0.500      P=0.418N    |P=0.076N     P=0.589      P=0.110N     P=0.151N     |
|POLY 1.5           |     P=0.183N     P=0.118      P=0.484      P=0.423N    |P=0.065N     P=0.572N     P=0.088N     P=0.133N     |
|POLY 6             |     P=0.165N     P=0.153      P=0.523      P=0.417N    |P=0.095N     P=0.590      P=0.144N     P=0.177N     |
|LOGISTIC REGRESSION|     P=0.202N     P=0.103      P=0.457      P=0.511N    |P=0.056N     P=0.497N     P=0.066N     P=0.114N     |
|COCH-ARM / FISHERS |     P=0.204N     P=0.103      P=0.463      P=0.436N    |P=0.057N     P=0.500N     P=0.064N     P=0.109N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/45 (7%)    5/48 (10%)   6/47 (13%)  |20/50 (40%)  23/50 (46%)  14/49 (29%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     2.6%         7.9%         12.7%        15.1%       |43.4%        48.8%        31.4%        40.6%        |
|TERMINAL (d)       |     1/20 (5%)    2/23 (9%)    5/24 (21%)   5/23 (22%)  |10/25 (40%)  15/33 (46%)  9/30 (30%)   12/31 (39%)  |
|FIRST INCIDENCE    |     729 (T)      707          729 (T)      569         |541          636          659          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.048 *    P=0.364      P=0.142      P=0.078     |P=0.204N     P=0.446N     P=0.087N     P=0.291N     |
|POLY 3             |     P=0.046 *    P=0.340      P=0.122      P=0.070     |P=0.291N     P=0.382      P=0.169N     P=0.480N     |
|POLY 1.5           |     P=0.041 *    P=0.307      P=0.108      P=0.059     |P=0.297N     P=0.353      P=0.167N     P=0.492N     |
|POLY 6             |     P=0.054      P=0.393      P=0.147      P=0.088     |P=0.280N     P=0.438      P=0.166N     P=0.455N     |
|LOGISTIC REGRESSION|     P=0.043 *    P=0.345      P=0.142      P=0.064     |P=0.304N     P=0.373      P=0.151N     P=0.500N     |
|COCH-ARM / FISHERS |     P=0.035 *    P=0.270      P=0.093      P=0.047 *   |P=0.305N     P=0.343      P=0.162N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/45 (0%)    0/48 (0%)    2/47 (4%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         5.1%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    2/23 (9%)   |1/25 (4%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.049 *    (e)          (e)          P=0.269     |P=0.293N     P=0.445N     P=0.464N     P=0.457N     |
|POLY 3             |     P=0.055      (e)          (e)          P=0.296     |P=0.348N     P=0.538N     P=0.552N     P=0.549N     |
|POLY 1.5           |     P=0.049 *    (e)          (e)          P=0.262     |P=0.331N     P=0.523N     P=0.530N     P=0.527N     |
|POLY 6             |     P=0.063      (e)          (e)          P=0.351     |P=0.374N     P=0.563N     P=0.586N     P=0.582N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.269     |P=0.293N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.232     |P=0.312N     P=0.500N     P=0.505N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/12 (75%)   10/11 (91%)  9/10 (90%)   12/14 (86%) |8/9 (89%)    10/11 (91%)  11/12 (92%)  9/10 (90%)   |
|POLY-3 ADJUSTED (b)|     75.1%        90.9%        92.2%        90.0%       |91.2%        90.9%        96.7%        90.1%        |
|TERMINAL (d)       |     4/6 (67%)    2/3 (67%)    5/5 (100%)   4/4 (100%)  |2/2 (100%)   8/9 (89%)    7/7 (100%)   4/4 (100%)   |
|FIRST INCIDENCE    |     578          544          457          520         |635          627          655          592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.229      P=0.389      P=0.570      P=0.235     |P=0.498      P=0.095N     P=0.347N     P=0.456N     |
|POLY 3             |     P=0.267      P=0.330      P=0.319      P=0.320     |P=0.650N     P=0.781N     P=0.717      P=0.764N     |
|POLY 1.5           |     P=0.329      P=0.329      P=0.341      P=0.368     |P=0.649      P=0.758      P=0.698      P=0.774N     |
|POLY 6             |     P=0.183      P=0.332      P=0.283      P=0.254     |P=0.625N     P=0.755N     P=0.799      P=0.743N     |
|LOGISTIC REGRESSION|     P=0.421      (e)          P=0.412      P=0.428     |P=0.605      P=0.749      P=0.680      P=0.725      |
|COCH-ARM / FISHERS |     P=0.406      P=0.329      P=0.368      P=0.422     |P=0.624      P=0.711      P=0.686      P=0.737      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/47 (4%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/48 (0%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         2.4%        |0.0%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    2/23 (9%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          648         |---          ---          708          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.587      P=0.269      (e)          P=0.539     |P=0.695      (e)          P=0.517      (e)          |
|POLY 3             |     P=0.620      P=0.298      (e)          P=0.610     |P=0.718      (e)          P=0.552      (e)          |
|POLY 1.5           |     P=0.593      P=0.263      (e)          P=0.561     |P=0.704      (e)          P=0.526      (e)          |
|POLY 6             |     P=0.657      P=0.354      (e)          P=0.683     |P=0.740      (e)          P=0.594      (e)          |
|LOGISTIC REGRESSION|     P=0.573      P=0.269      (e)          P=0.484     |P=0.688      (e)          P=0.498      (e)          |
|COCH-ARM / FISHERS |     P=0.558      P=0.232      (e)          P=0.500     |P=0.687      (e)          P=0.495      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/47 (0%)    0/49 (0%)    2/50 (4%)   |2/50 (4%)    9/48 (19%)   4/49 (8%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         0.0%         4.7%        |4.5%         20.3%        9.2%         6.8%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    6/33 (18%)   2/30 (7%)    2/31 (7%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          630         |698          678          694          668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.271      P=0.472N     P=0.464N     P=0.559     |P=0.322N     P=0.070      P=0.395      P=0.565      |
|POLY 3             |     P=0.270      P=0.589N     P=0.595N     P=0.585     |P=0.369N     P=0.027 *    P=0.354      P=0.525      |
|POLY 1.5           |     P=0.259      P=0.554N     P=0.553N     P=0.547     |P=0.378N     P=0.024 *    P=0.341      P=0.508      |
|POLY 6             |     P=0.287      P=0.643N     P=0.659N     P=0.638     |P=0.350N     P=0.035 *    P=0.378      P=0.555      |
|LOGISTIC REGRESSION|     P=0.245      (e)          (e)          P=0.505     |P=0.369N     P=0.034 *    P=0.340      P=0.503      |
|COCH-ARM / FISHERS |     P=0.246      P=0.515N     P=0.505N     P=0.500     |P=0.385N     P=0.021 *    P=0.329      P=0.490      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  2/47 (4%)    6/49 (12%)   5/50 (10%)  |2/50 (4%)    2/48 (4%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     24.4%        5.0%         14.4%        11.7%       |4.6%         4.5%         0.0%         0.0%         |
|TERMINAL (d)       |     6/20 (30%)   1/23 (4%)    1/24 (4%)    2/23 (9%)   |2/25 (8%)    1/33 (3%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     362          630          564          569         |734 (T)      484          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.193N     P=0.010N*    P=0.157N     P=0.097N    |P=0.072N     P=0.620N     P=0.198N     P=0.192N     |
|POLY 3             |     P=0.212N     P=0.016N*    P=0.203N     P=0.116N    |P=0.090N     P=0.705N     P=0.269N     P=0.265N     |
|POLY 1.5           |     P=0.213N     P=0.017N*    P=0.211N     P=0.121N    |P=0.088N     P=0.700      P=0.257N     P=0.255N     |
|POLY 6             |     P=0.214N     P=0.014N*    P=0.190N     P=0.111N    |P=0.092N     P=0.701N     P=0.288N     P=0.279N     |
|LOGISTIC REGRESSION|     P=0.243N     P=0.022N*    P=0.235N     P=0.147N    |P=0.086N     P=0.688      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.220N     P=0.018N*    P=0.220N     P=0.131N    |P=0.085N     P=0.676      P=0.253N     P=0.253N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/47 (4%)    1/49 (2%)    0/50 (0%)   |6/50 (12%)   3/48 (6%)    8/49 (16%)   12/49 (24%)  |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         2.5%         0.0%        |13.7%        6.8%         17.7%        27.0%        |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |5/25 (20%)   3/33 (9%)    2/30 (7%)    8/31 (26%)   |
|FIRST INCIDENCE    |     ---          723          714          ---         |729          734 (T)      597          668          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426N     P=0.270      P=0.532      (e)         |P=0.032 *    P=0.127N     P=0.483      P=0.200      |
|POLY 3             |     P=0.442N     P=0.298      P=0.607      (e)         |P=0.017 *    P=0.251N     P=0.421      P=0.103      |
|POLY 1.5           |     P=0.439N     P=0.263      P=0.557      (e)         |P=0.017 *    P=0.260N     P=0.396      P=0.094      |
|POLY 6             |     P=0.452N     P=0.354      P=0.681      (e)         |P=0.019 *    P=0.236N     P=0.466      P=0.122      |
|LOGISTIC REGRESSION|     P=0.424N     P=0.274      P=0.517      (e)         |P=0.018 *    P=0.143N     P=0.372      P=0.127      |
|COCH-ARM / FISHERS |     P=0.442N     P=0.232      P=0.495      (e)         |P=0.017 *    P=0.264N     P=0.371      P=0.088      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/47 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     7.7%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     709          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043N*    P=0.096N     P=0.094N     P=0.100N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.062N     P=0.143N     P=0.144N     P=0.135N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.055N     P=0.137N     P=0.133N     P=0.126N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.073N     P=0.155N     P=0.163N     P=0.152N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.044N*    P=0.093N     P=0.100N     P=0.097N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.051N     P=0.133N     P=0.125N     P=0.121N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  20/47 (43%)  16/49 (33%)  28/50 (56%) |1/50 (2%)    10/48 (21%)  1/49 (2%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     51.8%        46.6%        37.6%        61.3%       |2.3%         21.9%        2.3%         11.3%        |
|TERMINAL (d)       |     13/20 (65%)  7/23 (30%)   9/24 (38%)   14/23 (61%) |1/25 (4%)    3/33 (9%)    1/30 (3%)    3/31 (10%)   |
|FIRST INCIDENCE    |     445          502          457          520         |734 (T)      484          734 (T)      708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.250      P=0.255N     P=0.076N     P=0.370     |P=0.501      P=0.016 *    P=0.721N     P=0.153      |
|POLY 3             |     P=0.160      P=0.403N     P=0.135N     P=0.249     |P=0.473      P=0.005 **   P=0.788      P=0.112      |
|POLY 1.5           |     P=0.148      P=0.458N     P=0.149N     P=0.207     |P=0.455      P=0.004 **   P=0.773      P=0.105      |
|POLY 6             |     P=0.174      P=0.327N     P=0.120N     P=0.315     |P=0.507      P=0.008 **   P=0.807N     P=0.128      |
|LOGISTIC REGRESSION|     P=0.153      P=0.472N     P=0.142N     P=0.213     |P=0.440      P=0.004 **   P=0.721N     P=0.123      |
|COCH-ARM / FISHERS |     P=0.131      P=0.525N     P=0.170N     P=0.159     |P=0.440      P=0.003 **   P=0.747      P=0.098      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     21/50 (42%)  15/47 (32%)  23/49 (47%)  28/50 (56%) |2/50 (4%)    0/47 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     47.6%        36.0%        51.2%        60.6%       |5.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     8/20 (40%)   9/23 (39%)   11/24 (46%)  13/23 (57%) |0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)    |
|FIRST INCIDENCE    |     362          544          457          520         |580          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.096      P=0.092N     P=0.538N     P=0.302     |P=0.113N     P=0.220N     P=0.221N     P=0.220N     |
|POLY 3             |     P=0.041 *    P=0.196N     P=0.458      P=0.151     |P=0.146N     P=0.287N     P=0.290N     P=0.277N     |
|POLY 1.5           |     P=0.037 *    P=0.201N     P=0.425      P=0.135     |P=0.133N     P=0.270N     P=0.267N     P=0.257N     |
|POLY 6             |     P=0.046 *    P=0.190N     P=0.504      P=0.171     |P=0.169N     P=0.316N     P=0.328N     P=0.314N     |
|LOGISTIC REGRESSION|     P=0.030 *    P=0.213N     P=0.356      P=0.107     |P=0.124N     P=0.261N     P=0.247N     P=0.248N     |
|COCH-ARM / FISHERS |     P=0.032 *    P=0.207N     P=0.385      P=0.115     |P=0.120N     P=0.263N     P=0.253N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/47 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         0.0%         4.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     726          ---          ---          582         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.514      P=0.215N     P=0.206N     P=0.651N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.518      P=0.286N     P=0.289N     P=0.705N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.508      P=0.269N     P=0.266N     P=0.698N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.533      P=0.315N     P=0.327N     P=0.721N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.500      P=0.199N     P=0.204N     P=0.684N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.496      P=0.263N     P=0.253N     P=0.691N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/47 (0%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    1/48 (2%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     10.1%        0.0%         0.0%         2.4%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     658          ---          ---          502         |---          636          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.050N     P=0.058N     P=0.154N    |P=0.553N     P=0.518      (e)          (e)          |
|POLY 3             |     P=0.147N     P=0.073N     P=0.073N     P=0.183N    |P=0.574N     P=0.547      (e)          (e)          |
|POLY 1.5           |     P=0.138N     P=0.071N     P=0.068N     P=0.179N    |P=0.566N     P=0.521      (e)          (e)          |
|POLY 6             |     P=0.162N     P=0.079N     P=0.084N     P=0.195N    |P=0.585N     P=0.588      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.143N     P=0.063N     P=0.060N     P=0.200N    |P=0.563N     P=0.515      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.131N     P=0.066N     P=0.061N     P=0.181N    |P=0.553N     P=0.490      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |7/50 (14%)   4/50 (8%)    10/50 (20%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|                                                        |15.5%        8.7%         22.2%        17.8%        |
|TERMINAL (d)       |                                                        |2/25 (8%)    3/33 (9%)    7/30 (23%)   6/31 (19%)   |
|FIRST INCIDENCE    |                                                        |519          728          571          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.345      P=0.176N     P=0.392      P=0.598N     |
|POLY 3             |                                                        |P=0.266      P=0.264N     P=0.302      P=0.508      |
|POLY 1.5           |                                                        |P=0.268      P=0.267N     P=0.298      P=0.501      |
|POLY 6             |                                                        |P=0.269      P=0.257N     P=0.313      P=0.526      |
|LOGISTIC REGRESSION|                                                        |P=0.272      P=0.264N     P=0.296      P=0.499      |
|COCH-ARM / FISHERS |                                                        |P=0.272      P=0.262N     P=0.298      P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/48 (21%)  9/45 (20%)   13/46 (28%)  12/48 (25%) |12/47 (26%)  4/49 (8%)    3/49 (6%)    5/48 (10%)   |
|POLY-3 ADJUSTED (b)|     25.5%        23.0%        32.5%        28.7%       |28.1%        8.9%         6.8%         11.4%        |
|TERMINAL (d)       |     6/20 (30%)   6/23 (26%)   8/24 (33%)   7/23 (30%)  |7/25 (28%)   2/33 (6%)    1/30 (3%)    2/31 (7%)    |
|FIRST INCIDENCE    |     551          502          533          520         |582          678          528          700          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.379      P=0.381N     P=0.472      P=0.537     |P=0.045N*    P=0.011N*    P=0.009N**   P=0.032N*    |
|POLY 3             |     P=0.347      P=0.521N     P=0.345      P=0.488     |P=0.050N     P=0.019N*    P=0.008N**   P=0.045N*    |
|POLY 1.5           |     P=0.326      P=0.540N     P=0.312      P=0.452     |P=0.049N*    P=0.020N*    P=0.008N**   P=0.046N*    |
|POLY 6             |     P=0.371      P=0.495N     P=0.400      P=0.537     |P=0.051N     P=0.016N*    P=0.008N**   P=0.043N*    |
|LOGISTIC REGRESSION|     P=0.312      P=0.532N     P=0.311      P=0.436     |P=0.052N     P=0.021N*    P=0.010N*    P=0.043N*    |
|COCH-ARM / FISHERS |     P=0.295      P=0.563N     P=0.275      P=0.404     |P=0.053N     P=0.021N*    P=0.009N**   P=0.048N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/45 (0%)    1/46 (2%)    3/48 (6%)   |0/47 (0%)    1/49 (2%)    1/49 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         7.4%        |0.0%         2.2%         2.3%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    2/23 (9%)   |0/25 (0%)    0/33 (0%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          668          605         |---          728          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.024 *    (e)          P=0.513      P=0.146     |P=0.560N     P=0.546      P=0.536      (e)          |
|POLY 3             |     P=0.026 *    (e)          P=0.596      P=0.161     |P=0.595N     P=0.560      P=0.560      (e)          |
|POLY 1.5           |     P=0.023 *    (e)          P=0.548      P=0.141     |P=0.591N     P=0.536      P=0.536      (e)          |
|POLY 6             |     P=0.029 *    (e)          P=0.668      P=0.197     |P=0.600N     P=0.597      P=0.598      (e)          |
|LOGISTIC REGRESSION|     P=0.022 *    (e)          P=0.490      P=0.127     |P=0.570N     P=0.531      P=0.536      (e)          |
|COCH-ARM / FISHERS |     P=0.021 *    (e)          P=0.489      P=0.121     |P=0.585N     P=0.510      P=0.510      (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    0/45 (0%)    0/46 (0%)    0/48 (0%)   |0/47 (0%)    0/49 (0%)    0/49 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/20 (10%)   0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.106N     P=0.207N     P=0.198N     P=0.207N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.146N     P=0.289N     P=0.289N     P=0.278N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.133N     P=0.272N     P=0.269N     P=0.258N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.170N     P=0.318N     P=0.322N     P=0.315N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.106N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.121N     P=0.264N     P=0.258N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    2/49 (4%)    1/50 (2%)    0/47 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.7%         4.8%         2.5%         0.0%        |0.0%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    1/23 (4%)    1/24 (4%)    0/22 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     729 (T)      613          729 (T)      ---         |---          627          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.216N     P=0.556      P=0.710N     P=0.471N    |P=0.556N     P=0.513      (e)          (e)          |
|POLY 3             |     P=0.243N     P=0.596      P=0.797N     P=0.582N    |P=0.580N     P=0.555      (e)          (e)          |
|POLY 1.5           |     P=0.242N     P=0.557      P=0.776N     P=0.545N    |P=0.570N     P=0.530      (e)          (e)          |
|POLY 6             |     P=0.250N     P=0.653      P=0.829N     P=0.644N    |P=0.593N     P=0.597      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.225N     P=0.534      P=0.710N     (e)         |P=0.564N     P=0.529      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.244N     P=0.508      P=0.742N     P=0.505N    |P=0.555N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/48 (6%)    1/49 (2%)    3/49 (6%)    5/50 (10%)  |1/49 (2%)    0/50 (0%)    4/50 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     7.6%         2.4%         7.3%         11.7%       |2.3%         0.0%         9.0%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    1/24 (4%)    2/23 (9%)   |0/25 (0%)    0/33 (0%)    3/30 (10%)   0/31 (0%)    |
|FIRST INCIDENCE    |     445          636          572          520         |659          ---          721          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188      P=0.279N     P=0.623N     P=0.431     |P=0.463      P=0.472N     P=0.227      P=0.748N     |
|POLY 3             |     P=0.179      P=0.324N     P=0.680N     P=0.429     |P=0.447      P=0.534N     P=0.200      P=0.781N     |
|POLY 1.5           |     P=0.173      P=0.312N     P=0.667N     P=0.408     |P=0.442      P=0.519N     P=0.193      P=0.771N     |
|POLY 6             |     P=0.187      P=0.343N     P=0.698N     P=0.458     |P=0.456      P=0.558N     P=0.213      P=0.796N     |
|LOGISTIC REGRESSION|     P=0.134      P=0.353N     P=0.643      P=0.306     |P=0.437      P=0.484N     P=0.188      P=0.757N     |
|COCH-ARM / FISHERS |     P=0.164      P=0.301N     P=0.651N     P=0.381     |P=0.438      P=0.495N     P=0.187      P=0.747N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    3/49 (6%)    2/49 (4%)    2/50 (4%)   |13/49 (27%)  11/50 (22%)  11/50 (22%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     2.6%         7.2%         4.9%         4.8%        |29.2%        23.7%        24.4%        29.0%        |
|TERMINAL (d)       |     1/20 (5%)    1/23 (4%)    1/24 (4%)    0/23 (0%)   |8/25 (32%)   7/33 (21%)   9/30 (30%)   11/31 (36%)  |
|FIRST INCIDENCE    |     729 (T)      548          603          682         |519          636          528          691          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.547      P=0.352      P=0.551      P=0.542     |P=0.473N     P=0.210N     P=0.274N     P=0.387N     |
|POLY 3             |     P=0.568      P=0.381      P=0.577      P=0.587     |P=0.493      P=0.368N     P=0.402N     P=0.594N     |
|POLY 1.5           |     P=0.550      P=0.350      P=0.546      P=0.555     |P=0.502      P=0.384N     P=0.396N     P=0.585N     |
|POLY 6             |     P=0.593      P=0.430      P=0.624      P=0.634     |P=0.486      P=0.340N     P=0.406N     P=0.597N     |
|LOGISTIC REGRESSION|     P=0.518      P=0.304      P=0.516      P=0.534     |P=0.513      P=0.375N     P=0.385N     P=0.549N     |
|COCH-ARM / FISHERS |     P=0.523      P=0.316      P=0.508      P=0.515     |P=0.515      P=0.385N     P=0.385N     P=0.567N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         0.0%         0.0%        |4.6%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |1/25 (4%)    1/33 (3%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729          734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.536N     P=0.528      (e)          (e)         |P=0.085N     P=0.413N     P=0.205N     P=0.195N     |
|POLY 3             |     P=0.589N     P=0.605      (e)          (e)         |P=0.109N     P=0.507N     P=0.262N     P=0.259N     |
|POLY 1.5           |     P=0.568N     P=0.560      (e)          (e)         |P=0.104N     P=0.503N     P=0.249N     P=0.248N     |
|POLY 6             |     P=0.623N     P=0.672      (e)          (e)         |P=0.115N     P=0.512N     P=0.282N     P=0.276N     |
|LOGISTIC REGRESSION|     (e)          P=0.528      (e)          (e)         |P=0.088N     P=0.434N     P=0.214N     P=0.206N     |
|COCH-ARM / FISHERS |     P=0.546N     P=0.505      (e)          (e)         |P=0.099N     P=0.492N     P=0.242N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/48 (17%)   5/49 (10%)   5/49 (10%)   7/50 (14%)  |4/49 (8%)    6/50 (12%)   6/50 (12%)   0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     19.7%        11.9%        12.2%        16.4%       |9.2%         13.0%        13.6%        0.0%         |
|TERMINAL (d)       |     3/20 (15%)   3/23 (13%)   3/24 (13%)   4/23 (17%)  |3/25 (12%)   4/33 (12%)   6/30 (20%)   0/31 (0%)    |
|FIRST INCIDENCE    |     551          548          457          520         |701          636          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.450N     P=0.221N     P=0.222N     P=0.404N    |P=0.037N*    P=0.521      P=0.479      P=0.044N*    |
|POLY 3             |     P=0.501N     P=0.267N     P=0.284N     P=0.478N    |P=0.052N     P=0.425      P=0.399      P=0.064N     |
|POLY 1.5           |     P=0.493N     P=0.264N     P=0.272N     P=0.469N    |P=0.051N     P=0.402      P=0.390      P=0.062N     |
|POLY 6             |     P=0.518N     P=0.274N     P=0.304N     P=0.500N    |P=0.051N     P=0.462      P=0.416      P=0.067N     |
|LOGISTIC REGRESSION|     P=0.513N     P=0.297N     P=0.282N     P=0.500N    |P=0.047N*    P=0.419      P=0.427      P=0.052N     |
|COCH-ARM / FISHERS |     P=0.491N     P=0.263N     P=0.263N     P=0.465N    |P=0.052N     P=0.383      P=0.383      P=0.056N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    3/49 (6%)   |                                                    |
|POLY-3 ADJUSTED (b)|     7.5%         2.4%         4.9%         7.3%        |                                                    |
|TERMINAL (d)       |     1/20 (5%)    1/23 (4%)    1/24 (4%)    2/23 (9%)   |                                                    |
|FIRST INCIDENCE    |     529          729 (T)      667          672         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.515      P=0.269N     P=0.451N     P=0.605N    |                                                    |
|POLY 3             |     P=0.489      P=0.331N     P=0.532N     P=0.682N    |                                                    |
|POLY 1.5           |     P=0.476      P=0.318N     P=0.517N     P=0.675N    |                                                    |
|POLY 6             |     P=0.506      P=0.353N     P=0.558N     P=0.697N    |                                                    |
|LOGISTIC REGRESSION|     P=0.465      P=0.328N     P=0.515N     P=0.643     |                                                    |
|COCH-ARM / FISHERS |     P=0.459      P=0.309N     P=0.500N     P=0.651     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    4/50 (8%)    6/49 (12%)  |                                                    |
|POLY-3 ADJUSTED (b)|     12.4%        4.8%         9.8%         14.4%       |                                                    |
|TERMINAL (d)       |     3/20 (15%)   1/23 (4%)    2/24 (8%)    3/23 (13%)  |                                                    |
|FIRST INCIDENCE    |     362          697          710          630         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.334      P=0.176N     P=0.413N     P=0.588     |                                                    |
|POLY 3             |     P=0.294      P=0.226N     P=0.526N     P=0.549     |                                                    |
|POLY 1.5           |     P=0.283      P=0.222N     P=0.515N     P=0.520     |                                                    |
|POLY 6             |     P=0.311      P=0.233N     P=0.542N     P=0.594     |                                                    |
|LOGISTIC REGRESSION|     P=0.277      P=0.246N     P=0.507N     P=0.455     |                                                    |
|COCH-ARM / FISHERS |     P=0.268      P=0.218N     P=0.500N     P=0.486     |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.6%         4.8%         2.5%         4.7%        |                                                    |
|TERMINAL (d)       |     1/20 (5%)    1/23 (4%)    1/24 (4%)    1/23 (4%)   |                                                    |
|FIRST INCIDENCE    |     729 (T)      675          729 (T)      564         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.490      P=0.551      P=0.722N     P=0.543     |                                                    |
|POLY 3             |     P=0.499      P=0.582      P=0.805N     P=0.584     |                                                    |
|POLY 1.5           |     P=0.478      P=0.545      P=0.785N     P=0.547     |                                                    |
|POLY 6             |     P=0.527      P=0.636      P=0.836N     P=0.637     |                                                    |
|LOGISTIC REGRESSION|     P=0.466      P=0.543      P=0.722N     P=0.505     |                                                    |
|COCH-ARM / FISHERS |     P=0.449      P=0.500      P=0.753N     P=0.500     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   7/50 (14%)   5/50 (10%)  |                                                    |
|POLY-3 ADJUSTED (b)|     5.1%         11.8%        17.0%        11.9%       |                                                    |
|TERMINAL (d)       |     0/20 (0%)    3/23 (13%)   5/24 (21%)   4/23 (17%)  |                                                    |
|FIRST INCIDENCE    |     658          611          653          690         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.272      P=0.277      P=0.119      P=0.271     |                                                    |
|POLY 3             |     P=0.262      P=0.276      P=0.102      P=0.271     |                                                    |
|POLY 1.5           |     P=0.247      P=0.249      P=0.092      P=0.248     |                                                    |
|POLY 6             |     P=0.279      P=0.317      P=0.119      P=0.304     |                                                    |
|LOGISTIC REGRESSION|     P=0.255      P=0.231      P=0.096      P=0.260     |                                                    |
|COCH-ARM / FISHERS |     P=0.222      P=0.218      P=0.080      P=0.218     |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     714          ---          ---          663         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.439N     P=0.204N     P=0.203N     P=0.446N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.511N     P=0.278N     P=0.286N     P=0.529N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.492N     P=0.258N     P=0.262N     P=0.514N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.541N     P=0.312N     P=0.327N     P=0.558N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.453N     P=0.203N     P=0.213N     P=0.467N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.470N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.8%        |2.3%         0.0%         0.0%         2.2%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    1/23 (4%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          697         |712          ---          ---          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.049 *    (e)          (e)          P=0.267     |P=0.596      P=0.471N     P=0.482N     P=0.741N     |
|POLY 3             |     P=0.056      (e)          (e)          P=0.312     |P=0.605      P=0.538N     P=0.552N     P=0.785N     |
|POLY 1.5           |     P=0.051      (e)          (e)          P=0.278     |P=0.598      P=0.523N     P=0.529N     P=0.774N     |
|POLY 6             |     P=0.066      (e)          (e)          P=0.368     |P=0.616      P=0.563N     P=0.588N     P=0.799N     |
|LOGISTIC REGRESSION|     P=0.049 *    (e)          (e)          P=0.263     |P=0.588      P=0.494N     P=0.497N     P=0.760N     |
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.587      P=0.500N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     703          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.112N     P=0.197N     P=0.211N     P=0.215N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.146N     P=0.278N     P=0.286N     P=0.277N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.133N     P=0.258N     P=0.263N     P=0.257N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.168N     P=0.312N     P=0.327N     P=0.314N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.112N     P=0.213N     P=0.221N     P=0.214N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.120N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     7.5%         0.0%         4.9%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    2/24 (8%)    0/23 (0%)   |1/25 (4%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     532          ---          729 (T)      ---         |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.118N     P=0.110N     P=0.439N     P=0.110N    |P=0.293N     P=0.445N     P=0.464N     P=0.457N     |
|POLY 3             |     P=0.144N     P=0.138N     P=0.536N     P=0.138N    |P=0.347N     P=0.538N     P=0.552N     P=0.547N     |
|POLY 1.5           |     P=0.138N     P=0.129N     P=0.519N     P=0.128N    |P=0.331N     P=0.523N     P=0.529N     P=0.528N     |
|POLY 6             |     P=0.155N     P=0.155N     P=0.565N     P=0.157N    |P=0.373N     P=0.563N     P=0.589N     P=0.578N     |
|LOGISTIC REGRESSION|     P=0.141N     P=0.147N     P=0.510N     P=0.163N    |P=0.293N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.133N     P=0.121N     P=0.500N     P=0.121N    |P=0.314N     P=0.500N     P=0.500N     P=0.505N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  16/50 (32%)  19/50 (38%)  14/50 (28%) |3/50 (6%)    2/50 (4%)    2/50 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     25.3%        36.8%        44.1%        32.6%       |6.8%         4.4%         4.5%         2.3%         |
|TERMINAL (d)       |     6/20 (30%)   9/23 (39%)   10/24 (42%)  7/23 (30%)  |0/25 (0%)    1/33 (3%)    1/30 (3%)    1/31 (3%)    |
|FIRST INCIDENCE    |     658          592          572          648         |698          699          721          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.405      P=0.249      P=0.109      P=0.375     |P=0.204N     P=0.417N     P=0.454N     P=0.253N     |
|POLY 3             |     P=0.368      P=0.196      P=0.060      P=0.331     |P=0.247N     P=0.502N     P=0.522N     P=0.325N     |
|POLY 1.5           |     P=0.331      P=0.162      P=0.048 *    P=0.292     |P=0.244N     P=0.504N     P=0.512N     P=0.320N     |
|POLY 6             |     P=0.415      P=0.249      P=0.084      P=0.388     |P=0.250N     P=0.498N     P=0.534N     P=0.332N     |
|LOGISTIC REGRESSION|     P=0.350      P=0.186      P=0.051      P=0.339     |P=0.227N     P=0.474N     P=0.484N     P=0.286N     |
|COCH-ARM / FISHERS |     P=0.278      P=0.127      P=0.038 *    P=0.241     |P=0.240N     P=0.500N     P=0.500N     P=0.316N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   2/50 (4%)    2/50 (4%)   |7/50 (14%)   2/50 (4%)    3/50 (6%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.6%         11.7%        4.8%         4.8%        |15.7%        4.4%         6.6%         2.3%         |
|TERMINAL (d)       |     0/20 (0%)    2/23 (9%)    0/24 (0%)    1/23 (4%)   |2/25 (8%)    1/33 (3%)    1/30 (3%)    0/31 (0%)    |
|FIRST INCIDENCE    |     585          544          592          648         |646          691          525          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.232N     P=0.436      P=0.467N     P=0.438N    |P=0.029N*    P=0.051N     P=0.141N     P=0.026N*    |
|POLY 3             |     P=0.255N     P=0.428      P=0.523N     P=0.515N    |P=0.033N*    P=0.076N     P=0.159N     P=0.033N*    |
|POLY 1.5           |     P=0.257N     P=0.397      P=0.512N     P=0.505N    |P=0.032N*    P=0.079N     P=0.159N     P=0.033N*    |
|POLY 6             |     P=0.257N     P=0.471      P=0.544N     P=0.535N    |P=0.034N*    P=0.072N     P=0.158N     P=0.033N*    |
|LOGISTIC REGRESSION|     P=0.277N     P=0.345      P=0.519N     P=0.503N    |P=0.034N*    P=0.077N     P=0.156N     P=0.033N*    |
|COCH-ARM / FISHERS |     P=0.264N     P=0.357      P=0.500N     P=0.500N    |P=0.033N*    P=0.080N     P=0.159N     P=0.032N*    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.6%         2.4%         4.9%         2.4%        |0.0%         0.0%         0.0%         2.2%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    1/24 (4%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     580          548          641          630         |---          ---          ---          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.257N     P=0.265N     P=0.446N     P=0.265N    |P=0.195      (e)          (e)          P=0.510      |
|POLY 3             |     P=0.296N     P=0.321N     P=0.527N     P=0.323N    |P=0.215      (e)          (e)          P=0.551      |
|POLY 1.5           |     P=0.290N     P=0.313N     P=0.514N     P=0.313N    |P=0.206      (e)          (e)          P=0.526      |
|POLY 6             |     P=0.307N     P=0.338N     P=0.550N     P=0.343N    |P=0.231      (e)          (e)          P=0.593      |
|LOGISTIC REGRESSION|     P=0.306N     P=0.332N     P=0.492N     P=0.316N    |P=0.183      (e)          (e)          P=0.495      |
|COCH-ARM / FISHERS |     P=0.286N     P=0.309N     P=0.500N     P=0.309N    |P=0.193      (e)          (e)          P=0.495      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |7/50 (14%)   11/50 (22%)  8/50 (16%)   10/49 (20%)  |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         4.8%         4.7%        |15.6%        23.8%        17.4%        21.8%        |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    1/23 (4%)   |3/25 (12%)   7/33 (21%)   3/30 (10%)   4/31 (13%)   |
|FIRST INCIDENCE    |     579          ---          571          597         |629          682          506          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.456      P=0.224N     P=0.678N     P=0.659N    |P=0.440      P=0.398      P=0.574      P=0.406      |
|POLY 3             |     P=0.465      P=0.279N     P=0.721N     P=0.713N    |P=0.383      P=0.244      P=0.531      P=0.324      |
|POLY 1.5           |     P=0.451      P=0.259N     P=0.708N     P=0.702N    |P=0.365      P=0.228      P=0.517      P=0.304      |
|POLY 6             |     P=0.484      P=0.314N     P=0.741N     P=0.734N    |P=0.412      P=0.271      P=0.555      P=0.358      |
|LOGISTIC REGRESSION|     P=0.368      P=0.280N     P=0.651      P=0.636     |P=0.337      P=0.240      P=0.502      P=0.265      |
|COCH-ARM / FISHERS |     P=0.432      P=0.247N     P=0.691N     P=0.691N    |P=0.343      P=0.218      P=0.500      P=0.282      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Capsule                                                                                                                  |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     5.1%         4.8%         4.9%         0.0%        |0.0%         0.0%         0.0%         4.5%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    2/24 (8%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    1/31 (3%)    |
|FIRST INCIDENCE    |     709          711          729 (T)      ---         |---          ---          ---          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.140N     P=0.624N     P=0.630N     P=0.212N    |P=0.049 *    (e)          (e)          P=0.266      |
|POLY 3             |     P=0.163N     P=0.713N     P=0.724N     P=0.277N    |P=0.048 *    (e)          (e)          P=0.269      |
|POLY 1.5           |     P=0.162N     P=0.703N     P=0.709N     P=0.257N    |P=0.046 *    (e)          (e)          P=0.251      |
|POLY 6             |     P=0.169N     P=0.731N     P=0.749N     P=0.314N    |P=0.052      (e)          (e)          P=0.298      |
|LOGISTIC REGRESSION|     P=0.141N     P=0.642N     P=0.655N     P=0.209N    |P=0.042 *    (e)          (e)          P=0.228      |
|COCH-ARM / FISHERS |     P=0.162N     P=0.691N     P=0.691N     P=0.247N    |P=0.044 *    (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/49 (4%)    2/48 (4%)    0/49 (0%)   |5/50 (10%)   1/50 (2%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     7.5%         4.9%         5.1%         0.0%        |11.1%        2.2%         0.0%         6.7%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     502          716          686          ---         |597          627          ---          698          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.080N     P=0.443N     P=0.465N     P=0.112N    |P=0.344N     P=0.087N     P=0.034N*    P=0.321N     |
|POLY 3             |     P=0.093N     P=0.532N     P=0.549N     P=0.142N    |P=0.370N     P=0.103N     P=0.036N*    P=0.376N     |
|POLY 1.5           |     P=0.091N     P=0.521N     P=0.534N     P=0.132N    |P=0.360N     P=0.104N     P=0.034N*    P=0.369N     |
|POLY 6             |     P=0.099N     P=0.551N     P=0.571N     P=0.160N    |P=0.382N     P=0.102N     P=0.040N*    P=0.383N     |
|LOGISTIC REGRESSION|     P=0.093N     P=0.535N     P=0.543N     P=0.171N    |P=0.354N     P=0.089N     P=0.029N*    P=0.354N     |
|COCH-ARM / FISHERS |     P=0.090N     P=0.510N     P=0.520N     P=0.125N    |P=0.352N     P=0.102N     P=0.028N*    P=0.357N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  10/49 (20%)  8/48 (17%)   13/49 (27%) |2/50 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     23.9%        23.3%        19.3%        30.0%       |4.5%         4.3%         6.7%         8.8%         |
|TERMINAL (d)       |     1/20 (5%)    0/23 (0%)    1/24 (4%)    3/23 (13%)  |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     362          555          533          502         |653          699          608          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.362      P=0.479N     P=0.332N     P=0.440     |P=0.231      P=0.634N     P=0.518      P=0.373      |
|POLY 3             |     P=0.288      P=0.591N     P=0.419N     P=0.363     |P=0.224      P=0.700N     P=0.527      P=0.365      |
|POLY 1.5           |     P=0.273      P=0.605N     P=0.427N     P=0.334     |P=0.220      P=0.700N     P=0.514      P=0.351      |
|POLY 6             |     P=0.308      P=0.569N     P=0.406N     P=0.406     |P=0.233      P=0.700N     P=0.550      P=0.390      |
|LOGISTIC REGRESSION|     P=0.213      P=0.528      P=0.489N     P=0.249     |P=0.212      P=0.695N     P=0.507      P=0.339      |
|COCH-ARM / FISHERS |     P=0.252      P=0.579      P=0.435N     P=0.298     |P=0.214      P=0.691N     P=0.500      P=0.339      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    4/49 (8%)    2/48 (4%)    1/49 (2%)   |4/50 (8%)    3/50 (6%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     7.4%         9.5%         5.1%         2.4%        |8.9%         6.5%         6.7%         6.6%         |
|TERMINAL (d)       |     0/20 (0%)    1/23 (4%)    1/24 (4%)    1/23 (4%)   |0/25 (0%)    2/33 (6%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     362          611          720          729 (T)     |597          484          506          561          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.139N     P=0.556      P=0.457N     P=0.284N    |P=0.418N     P=0.424N     P=0.472N     P=0.459N     |
|POLY 3             |     P=0.166N     P=0.554      P=0.553N     P=0.339N    |P=0.454N     P=0.494N     P=0.514N     P=0.511N     |
|POLY 1.5           |     P=0.164N     P=0.524      P=0.537N     P=0.326N    |P=0.450N     P=0.499N     P=0.508N     P=0.507N     |
|POLY 6             |     P=0.171N     P=0.600      P=0.576N     P=0.363N    |P=0.458N     P=0.488N     P=0.523N     P=0.513N     |
|LOGISTIC REGRESSION|     P=0.188N     P=0.403      P=0.562N     P=0.424N    |P=0.445N     P=0.486N     P=0.487N     P=0.490N     |
|COCH-ARM / FISHERS |     P=0.163N     P=0.489      P=0.520N     P=0.316N    |P=0.444N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 51
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         2.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/20 (5%)    1/23 (4%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     362          729 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.092N     P=0.468N     P=0.220N     P=0.224N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.116N     P=0.544N     P=0.295N     P=0.278N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.109N     P=0.527N     P=0.272N     P=0.258N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.128N     P=0.571N     P=0.333N     P=0.315N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.124N     P=0.563N     P=0.298N     P=0.369N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.102N     P=0.508N     P=0.258N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/50 (34%)  14/49 (29%)  13/48 (27%)  17/50 (34%) |12/50 (24%)  6/50 (12%)   7/50 (14%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     39.6%        32.0%        30.2%        36.3%       |26.0%        12.8%        15.3%        15.3%        |
|TERMINAL (d)       |     4/20 (20%)   0/23 (0%)    0/24 (0%)    1/23 (4%)   |0/25 (0%)    1/33 (3%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     494          548          533          502         |635          627          528          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.480N     P=0.227N     P=0.209N     P=0.432N    |P=0.187N     P=0.066N     P=0.158N     P=0.136N     |
|POLY 3             |     P=0.494N     P=0.310N     P=0.253N     P=0.467N    |P=0.199N     P=0.090N     P=0.159N     P=0.162N     |
|POLY 1.5           |     P=0.531N     P=0.328N     P=0.272N     P=0.511N    |P=0.194N     P=0.095N     P=0.157N     P=0.160N     |
|POLY 6             |     P=0.456N     P=0.290N     P=0.232N     P=0.421N    |P=0.205N     P=0.084N     P=0.163N     P=0.163N     |
|LOGISTIC REGRESSION|     P=0.412      P=0.375N     P=0.328N     P=0.485     |P=0.186N     P=0.099N     P=0.148N     P=0.154N     |
|COCH-ARM / FISHERS |     P=0.489      P=0.358N     P=0.301N     P=0.583N    |P=0.188N     P=0.096N     P=0.154N     P=0.154N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 52
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    0/24 (0%)    0/23 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          694          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.603      (e)          P=0.260      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.612      (e)          P=0.271      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.601      (e)          P=0.255      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.632      (e)          P=0.299      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.587      (e)          P=0.239      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.587      (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   9/49 (18%)   12/50 (24%)  8/50 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     20.1%        21.1%        28.3%        18.3%       |                                                    |
|TERMINAL (d)       |     3/20 (15%)   3/23 (13%)   6/24 (25%)   1/23 (4%)   |                                                    |
|FIRST INCIDENCE    |     599          544          564          520         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.463N     P=0.584N     P=0.350      P=0.496N    |                                                    |
|POLY 3             |     P=0.482N     P=0.586      P=0.288      P=0.549N    |                                                    |
|POLY 1.5           |     P=0.509N     P=0.541      P=0.261      P=0.571N    |                                                    |
|POLY 6             |     P=0.456N     P=0.643N     P=0.329      P=0.526N    |                                                    |
|LOGISTIC REGRESSION|     P=0.535N     P=0.531      P=0.260      P=0.592N    |                                                    |
|COCH-ARM / FISHERS |     P=0.543      P=0.482      P=0.227      P=0.607N    |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 53
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Artery                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    2/50 (4%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         4.8%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/20 (0%)    0/23 (0%)    2/24 (8%)    1/23 (4%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          729 (T)      676         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.097      (e)          P=0.278      P=0.276     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.104      (e)          P=0.309      P=0.313     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.095      (e)          P=0.275      P=0.278     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.117      (e)          P=0.364      P=0.369     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.092      (e)          P=0.278      P=0.258     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.085      (e)          P=0.247      P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   11/49 (22%)  10/50 (20%)  8/50 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     18.7%        24.9%        22.7%        18.2%       |                                                    |
|TERMINAL (d)       |     0/20 (0%)    3/23 (13%)   2/24 (8%)    2/23 (9%)   |                                                    |
|FIRST INCIDENCE    |     494          502          457          520         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.398N     P=0.414      P=0.466      P=0.529N    |                                                    |
|POLY 3             |     P=0.439N     P=0.340      P=0.435      P=0.603N    |                                                    |
|POLY 1.5           |     P=0.440N     P=0.318      P=0.420      P=0.601N    |                                                    |
|POLY 6             |     P=0.447N     P=0.372      P=0.458      P=0.612N    |                                                    |
|LOGISTIC REGRESSION|     P=0.507      P=0.155      P=0.281      P=0.397     |                                                    |
|COCH-ARM / FISHERS |     P=0.450N     P=0.288      P=0.398      P=0.607N    |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 54
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/49 (61%)  19/47 (40%)  18/48 (38%)  27/47 (57%) |16/48 (33%)  10/49 (20%)  17/50 (34%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     63.1%        44.0%        41.8%        60.7%       |35.7%        21.8%        36.5%        30.2%        |
|TERMINAL (d)       |     7/20 (35%)   5/22 (23%)   5/22 (23%)   11/22 (50%) |6/25 (24%)   4/33 (12%)   9/30 (30%)   6/31 (19%)   |
|FIRST INCIDENCE    |     362          544          559          520         |541          676          506          562          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.382N     P=0.030N*    P=0.029N*    P=0.252N    |P=0.475N     P=0.064N     P=0.526N     P=0.293N     |
|POLY 3             |     P=0.499      P=0.050N     P=0.032N*    P=0.496N    |P=0.530N     P=0.110N     P=0.563      P=0.375N     |
|POLY 1.5           |     P=0.509      P=0.042N*    P=0.024N*    P=0.469N    |P=0.523N     P=0.115N     P=0.559      P=0.373N     |
|POLY 6             |     P=0.486      P=0.063N     P=0.043N*    P=0.530N    |P=0.533N     P=0.101N     P=0.570      P=0.369N     |
|LOGISTIC REGRESSION|     P=0.430      P=0.068N     P=0.021N*    P=0.568     |P=0.513N     P=0.116N     P=0.561      P=0.362N     |
|COCH-ARM / FISHERS |     P=0.523      P=0.033N*    P=0.016N*    P=0.433N    |P=0.514N     P=0.113N     P=0.557      P=0.362N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    0/47 (0%)    3/48 (6%)    2/47 (4%)   |1/48 (2%)    1/49 (2%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     7.6%         0.0%         7.6%         5.0%        |2.3%         2.2%         2.2%         6.5%         |
|TERMINAL (d)       |     0/20 (0%)    0/22 (0%)    1/22 (5%)    0/22 (0%)   |0/25 (0%)    0/33 (0%)    0/30 (0%)    0/31 (0%)    |
|FIRST INCIDENCE    |     551          ---          457          663         |641          484          663          449          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.573N     P=0.113N     P=0.627N     P=0.451N    |P=0.172      P=0.753N     P=0.755N     P=0.333      |
|POLY 3             |     P=0.599      P=0.143N     P=0.697N     P=0.530N    |P=0.181      P=0.768N     P=0.779N     P=0.352      |
|POLY 1.5           |     P=0.587      P=0.135N     P=0.681      P=0.523N    |P=0.178      P=0.764N     P=0.767N     P=0.338      |
|POLY 6             |     P=0.617      P=0.159N     P=0.721N     P=0.546N    |P=0.187      P=0.776N     P=0.796N     P=0.376      |
|LOGISTIC REGRESSION|     P=0.512      P=0.164N     P=0.619      P=0.598N    |P=0.154      P=0.694N     P=0.743N     P=0.421      |
|COCH-ARM / FISHERS |     P=0.569      P=0.129N     P=0.651      P=0.520N    |P=0.171      P=0.747N     P=0.742N     P=0.324      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 55
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus: Epithelial Cell                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   3/47 (6%)    2/48 (4%)    3/47 (6%)   |7/48 (15%)   6/49 (12%)   9/50 (18%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     13.1%        7.5%         5.2%         7.6%        |16.5%        13.3%        20.3%        9.0%         |
|TERMINAL (d)       |     4/20 (20%)   2/22 (9%)    2/22 (9%)    3/22 (14%)  |5/25 (20%)   5/33 (15%)   7/30 (23%)   4/31 (13%)   |
|FIRST INCIDENCE    |     703          592          729 (T)      729 (T)     |712          682          694          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.262N     P=0.293N     P=0.174N     P=0.299N    |P=0.189N     P=0.312N     P=0.528      P=0.159N     |
|POLY 3             |     P=0.313N     P=0.358N     P=0.238N     P=0.366N    |P=0.247N     P=0.468N     P=0.443      P=0.245N     |
|POLY 1.5           |     P=0.312N     P=0.366N     P=0.231N     P=0.369N    |P=0.244N     P=0.480N     P=0.435      P=0.244N     |
|POLY 6             |     P=0.321N     P=0.352N     P=0.254N     P=0.370N    |P=0.250N     P=0.447N     P=0.462      P=0.245N     |
|LOGISTIC REGRESSION|     P=0.267N     P=0.303N     P=0.185N     P=0.298N    |P=0.217N     P=0.390N     P=0.461      P=0.183N     |
|COCH-ARM / FISHERS |     P=0.314N     P=0.381N     P=0.226N     P=0.381N    |P=0.239N     P=0.484N     P=0.428      P=0.239N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   5/50 (10%)   4/50 (8%)   |10/50 (20%)  11/50 (22%)  6/50 (12%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     10.2%        14.4%        12.2%        9.6%        |22.5%        23.8%        13.4%        17.8%        |
|TERMINAL (d)       |     2/20 (10%)   5/23 (22%)   4/24 (17%)   3/23 (13%)  |7/25 (28%)   9/33 (27%)   4/30 (13%)   7/31 (23%)   |
|FIRST INCIDENCE    |     611          707          648          721         |646          678          597          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.409N     P=0.464      P=0.586      P=0.577N    |P=0.174N     P=0.438N     P=0.136N     P=0.245N     |
|POLY 3             |     P=0.456N     P=0.436      P=0.559      P=0.645N    |P=0.250N     P=0.551      P=0.206N     P=0.397N     |
|POLY 1.5           |     P=0.462N     P=0.407      P=0.534      P=0.641N    |P=0.251N     P=0.522      P=0.208N     P=0.400N     |
|POLY 6             |     P=0.457N     P=0.476      P=0.595      P=0.659N    |P=0.247N     P=0.598      P=0.202N     P=0.388N     |
|LOGISTIC REGRESSION|     P=0.422N     P=0.447      P=0.542      P=0.584N    |P=0.239N     P=0.599      P=0.197N     P=0.355N     |
|COCH-ARM / FISHERS |     P=0.478N     P=0.370      P=0.500      P=0.643N    |P=0.249N     P=0.500      P=0.207N     P=0.398N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 56
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         2.2%         4.5%         0.0%         |
|TERMINAL (d)       |                                                        |0/25 (0%)    1/33 (3%)    2/30 (7%)    0/31 (0%)    |
|FIRST INCIDENCE    |                                                        |---          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.581N     P=0.555      P=0.279      (e)          |
|POLY 3             |                                                        |P=0.626N     P=0.555      P=0.270      (e)          |
|POLY 1.5           |                                                        |P=0.621N     P=0.530      P=0.254      (e)          |
|POLY 6             |                                                        |P=0.631N     P=0.597      P=0.298      (e)          |
|LOGISTIC REGRESSION|                                                        |(e)          P=0.555      P=0.279      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.612N     P=0.500      P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/50 (8%)    0/50 (0%)    3/50 (6%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |9.1%         0.0%         6.7%         11.2%        |
|TERMINAL (d)       |                                                        |3/25 (12%)   0/33 (0%)    2/30 (7%)    3/31 (10%)   |
|FIRST INCIDENCE    |                                                        |635          ---          655          693          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.237      P=0.039N*    P=0.426N     P=0.603      |
|POLY 3             |                                                        |P=0.199      P=0.063N     P=0.516N     P=0.526      |
|POLY 1.5           |                                                        |P=0.199      P=0.063N     P=0.510N     P=0.512      |
|POLY 6             |                                                        |P=0.201      P=0.063N     P=0.522N     P=0.553      |
|LOGISTIC REGRESSION|                                                        |P=0.199      P=0.060N     P=0.496N     P=0.520      |
|COCH-ARM / FISHERS |                                                        |P=0.199      P=0.059N     P=0.500N     P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 05                                            Page 57
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        150 PPM      325 PPM      650 PPM     |0 PPM        150 PPM      325 PPM      650 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         2.2%         6.8%         0.0%         |
|TERMINAL (d)       |                                                        |0/25 (0%)    1/33 (3%)    3/30 (10%)   0/31 (0%)    |
|FIRST INCIDENCE    |                                                        |---          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.597N     P=0.555      P=0.154      (e)          |
|POLY 3             |                                                        |P=0.645N     P=0.555      P=0.137      (e)          |
|POLY 1.5           |                                                        |P=0.641N     P=0.530      P=0.128      (e)          |
|POLY 6             |                                                        |P=0.648N     P=0.597      P=0.153      (e)          |
|LOGISTIC REGRESSION|                                                        |(e)          P=0.555      P=0.154      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.633      P=0.500      P=0.121      (e)          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).