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TDMS Study 05160-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 07/30/97       
EXPERIMENT: 05160 TEST: 05                                                                                     TIME: 08:48:14       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C       
PATHOLOGIST: STEDHAM, M.                                                                                       CAS: 127-00-4        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           2 YEAR CHRONIC                                                           
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 07/30/97      
EXPERIMENT: 05160 TEST: 05                                                                                     TIME: 08:48:14      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C      
PATHOLOGIST: STEDHAM, M.                                                                                       CAS: 127-00-4       
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      362   445   494   502   529   532   551   578   579   579                 |
 |      580   585   599   611   616   629   635   637   655   658                 |
 |      673   687   693   693   697   703   709   714   726   726                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 150 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      388   502   544   548   555   555   592   593   609   611                 |
 |      613   630   636   643   655   657   675   693   697   706                 |
 |      707   711   716   718   721   723   728                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 325 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      408   457   533   559   564   571   572   573   582   592                 |
 |      603   606   627   639   641   648   653   667   668   686                 |
 |      690   695   710   714   720   728                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 650 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      502   520   520   564   569   569   582   585   597   605                 |
 |      630   648   648   663   672   676   676   682   683   686                 |
 |      690   697   707   709   714   721   728                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.0  98.0  96.0  88.0  74.0  60.0  40.0      |
 |           |                                                                    |
 |           |                                                                    |
 |150 PPM    |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  84.0  68.0  46.0      |
 |           |                                                                    |
 |           |                                                                    |
 |325 PPM    |   100.0 100.0 100.0 100.0  98.0  96.0  94.0  78.0  66.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 |650 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  80.0  72.0  46.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        150 PPM      325 PPM      650 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       40.0%        46.0%        48.0%        46.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.564N     P=0.476N     P=0.507N     P=0.514N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       612.6        634.3        619.5        638.6    |
 |NATURAL DEATHS (C)      |       (16.2)       (15.8)       (15.5)       (13.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       659.1        677.9        672.0        680.2    |
 |(STANDARD ERROR)        |       (12.6)       (10.8)       (11.2)       ( 9.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      519   541   582   597   609   629   635   641   646   653                 |
 |      659   670   672   672   680   698   701   709   712   719                 |
 |      720   722   727   729   729                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 150 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      217   484   627   636   676   677   678   678   682   691                 |
 |      699   708   708   712   712   716   728                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 325 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      506   525   528   571   597   608   613   655   659   661                 |
 |      663   668   694   697   708   714   717   718   721   733                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 650 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      449   489   561   562   592   634   639   649   656   668                 |
 |      691   693   698   700   708   714   722   731   733                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  92.0  78.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |150 PPM    |   100.0 100.0  98.0  98.0  98.0  96.0  96.0  96.0  92.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |325 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  90.0  78.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |650 PPM    |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0  82.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        150 PPM      325 PPM      650 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.0%        66.0%        60.0%        62.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.513N     P=0.137N     P=0.474N     P=0.334N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       662.8        648.8        647.8        646.8    |
 |NATURAL DEATHS (C)      |       (11.7)       (30.2)       (16.0)       (18.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       698.4        705.0        699.5        700.9    |
 |(STANDARD ERROR)        |       ( 7.7)       (11.6)       ( 8.7)       ( 9.3)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        1-CHLORO-2-PROPANOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        150 PPM          = 2
                                                        325 PPM          = 3
                                                        650 PPM          = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                        1    2  3             4
      |                                                          1    2  3    1  3     2   4
      |                                                                       1  3    11   4 32234
      |                                                                                1    1  2234
P  90 +                                                                                          33
E     |                                                                                     1  12 4 4 2
R     |                                                                                        1  313 242
C     |                                                                                             3 3422
E  80 +                                                                                               3 3  4
N     |                                                                                            11    2 2  4
T     |                                                                                             1  131 2224  4
      |                                                                                                      2 2 44
S  70 +                                                                                                  1 1 33   44
U     |                                                                                                    11 32   2
R     |                                                                                                     1  1  32422
V     |                                                                                                           3 3 22
I  60 +                                                                                                        1   133
V     |                                                                                                            1 1322
A     |                                                                                                               3422
L     |                                                                                                              11 33
   50 +                                                                                                               11422
      |                                                                                                                1143 3
      |                                                                                                                 1 1 2
      |
   40 +                                                                                                                   1 1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 39 obs hidden.
                                                        1-CHLORO-2-PROPANOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        150 PPM          = 2
                                                        325 PPM          = 3
                                                        650 PPM          = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                 2                                     4       3  1
      |
      |                                   2                                     4    2  3  1  1
      |                                                                              2     33 1  4  1      2
   95 +
      |                                                                                     3     3 1  1   22
      |                                                                                          43   411   2      2
      |
   90 +                                                                                               431  14
      |
      |                                                                                                 33 114
      |                                                                                                  3  1143
P  85 +
E     |                                                                                                      113 3 22
R     |                                                                                                       11  4 22
C     |
E  80 +                                                                                                        1 14  22
N     |
T     |                                                                                                          11   2 2
      |                                                                                                           3  43
S  75 +
U     |
R     |                                                                                                           1 1 3 3
V     |
I  70 +                                                                                                             1 1 22
V     |
A     |                                                                                                               11322
L     |                                                                                                                11 2 2
   65 +
      |
      |                                                                                                                 11  3
      |
   60 +                                                                                                                     3
      |
      |                                                                                                                  11
      |
   55 +
      |                                                                                                                   1 1
      |
      |
   50 +                                                                                                                     1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 26 obs hidden.