Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2594

TDMS Study 05160-06 Pathology Tables

NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97
Route: DOSED WATER                                                                                                Time: 09:11:09

                                                         2 YEAR CHRONIC




       Facility:  TSI Mason Research

       Chemical CAS #:  127-00-4

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7           11           10           11                                     
    Moribund Sacrifice                                 8            7            3            5                                     
    Accidently Killed                                  3                         1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           32           36           32                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (44)         (45)         (40)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                                                                1 (3%)                                
   Intestine Large, Cecum                             (44)         (46)         (48)         (49)                                   
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (45)         (47)         (46)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid             2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Peyer's Patch, Inflammation, Acute                                                      1 (2%)                                
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (44)         (45)         (45)                                   
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                 2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Eosinophilic Focus                              29 (58%)     24 (48%)     29 (58%)     31 (62%)                               
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)       2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Leukocytosis                                     1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                              2 (4%)                    1 (2%)                                
      Necrosis                                         1 (2%)       3 (6%)       1 (2%)                                             
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic            1 (2%)       1 (2%)                                                          
      Hepatocyte, Portal, Vacuolization Cytoplasmic                                           1 (2%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                            1 (2%)                                             
      Serosa, Inflammation, Chronic Active             1 (2%)                    1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (20)         (19)         (16)         (12)                                   
      Inflammation, Chronic Active                                               1 (6%)                                             
      Fat, Necrosis                                   19 (95%)     17 (89%)     14 (88%)     11 (92%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  1 (2%)       1 (2%)                    3 (6%)                                
      Acinus, Hyperplasia                                                        1 (2%)       1 (2%)                                
      Duct, Cyst                                                    1 (2%)                    2 (4%)                                
      Serosa, Inflammation, Chronic Active                                                    1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            3 (6%)       2 (4%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                            1 (2%)       2 (4%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (48)         (50)                                   
      Erosion                                          5 (10%)      2 (4%)       2 (4%)       2 (4%)                                
      Mineralization                                                1 (2%)                                                          
      Glands, Hyperplasia                                           1 (2%)                                                          
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cardiomyopathy                                   5 (10%)      2 (4%)                    2 (4%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)       2 (4%)                                             
      Atrium, Thrombosis                               1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Capsule, Hyperplasia                            48 (96%)     50 (100%)    49 (98%)     48 (96%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                             2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     28 (56%)     30 (60%)     30 (60%)     31 (62%)                               
      Hypertrophy                                                                             1 (2%)                                
   Pituitary Gland                                    (49)         (49)         (47)         (46)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Angiectasis                       2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Pars Distalis, Cyst                                           1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                       5 (10%)      3 (6%)       8 (17%)     10 (22%)                               
      Pars Intermedia, Hemorrhage                      1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                                           1 (2%)                                                          
      Follicular Cell, Hyperplasia                    13 (26%)      6 (12%)     15 (30%)     13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (48)         (49)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Pigmentation                                     2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Angiectasis                                                   2 (4%)                    2 (4%)                                
      Cyst                                            11 (22%)      9 (18%)      9 (18%)     11 (22%)                               
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Oviduct                                            (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                    3 (6%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Cystic                             41 (82%)     46 (92%)     43 (86%)     44 (88%)                               
      Inflammation, Acute                              1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Vagina                                                                       (1)                                                 
      Fibrosis                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Depletion Cellular                                            2 (4%)                                                          
      Myelofibrosis                                                              1 (2%)                                             
   Lymph Node                                         (8)          (12)         (15)         (9)                                    
      Iliac, Angiectasis                                                         2 (13%)                                            
      Iliac, Hemorrhage                                                                       1 (11%)                               
      Iliac, Hyperplasia, Lymphoid                     2 (25%)      2 (17%)      2 (13%)                                            
      Iliac, Infiltration Cellular, Plasma Cell        1 (13%)      1 (8%)       1 (7%)                                             
      Mediastinal, Angiectasis                                                   1 (7%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hemorrhage                          1 (13%)                                                                      
      Mediastinal, Inflammation, Acute                 1 (13%)                                                                      
      Mediastinal, Pigmentation                                                               1 (11%)                               
      Renal, Angiectasis                                            1 (8%)                                                          
      Renal, Ectasia                                                1 (8%)                                                          
      Renal, Hemorrhage                                                          1 (7%)                                             
      Renal, Hyperplasia, Lymphoid                                               4 (27%)                                            
      Renal, Infiltration Cellular, Plasma Cell                                  1 (7%)                                             
   Lymph Node, Mandibular                             (50)         (49)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Infiltration Cellular, Plasma Cell               1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (48)         (47)         (49)                                   
      Angiectasis                                      1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Ectasia                                                       1 (2%)       1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                13 (27%)      9 (18%)     16 (32%)     11 (22%)                               
      Hyperplasia, Lymphoid                                         3 (6%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                 1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute         1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           8 (16%)      6 (12%)      5 (10%)      4 (8%)                                
      Hyperplasia                                                                2 (4%)                                             
   Skeletal Muscle                                                 (1)                       (2)                                    
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Demyelination                                    1 (2%)                                 1 (2%)                                
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Thalamus, Mineralization                        22 (44%)     27 (55%)     22 (44%)     22 (44%)                               
   Peripheral Nerve                                   (2)                                                                           
      Demyelination                                    1 (50%)                                                                      
   Spinal Cord                                        (2)                       (1)                                                 
      Cyst Epithelial Inclusion                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       4 (8%)       3 (6%)       6 (12%)      3 (6%)                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Infiltration Cellular, Histiocyte                4 (8%)       2 (4%)       2 (4%)       4 (8%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Thrombosis                                       1 (2%)                    1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                              1 (2%)                    1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      External Ear, Inflammation, Chronic                                                     1 (100%)                              
   Eye                                                                                       (3)                                    
      Atrophy                                                                                 1 (33%)                               
      Inflammation, Acute                                                                     1 (33%)                               
      Cornea, Inflammation, Acute                                                             1 (33%)                               
      Cornea, Necrosis                                                                        1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hydronephrosis                                   1 (2%)                    3 (6%)       1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)                    1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy, Acute                                            1 (2%)                                                          
      Nephropathy, Chronic                            16 (32%)      6 (12%)      9 (18%)     11 (22%)                               
      Pigmentation                                     1 (2%)                                                                       
      Renal Tubule, Accumulation, Hyaline Droplet      3 (6%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Dilatation                                                                1 (2%)                                
   Urinary Bladder                                    (48)         (49)         (48)         (49)                                   
      Inflammation, Acute                                                        1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8                         7            4                                     
    Natural Death                                      2            6            9            4                                     
    Accidently Killed                                                            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           44           29           39                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (49)                                   
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Intestine Large, Cecum                             (49)         (50)         (48)         (47)                                   
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (44)         (47)                                   
      Diverticulum                                     1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Clear Cell Focus                                 2 (4%)      11 (22%)      6 (12%)      3 (6%)                                
      Eosinophilic Focus                              27 (54%)     34 (68%)     33 (66%)     29 (58%)                               
      Erythrophagocytosis                                           1 (2%)                                                          
      Inflammation, Chronic                            2 (4%)       1 (2%)                    1 (2%)                                
      Mixed Cell Focus                                 2 (4%)       5 (10%)      1 (2%)       3 (6%)                                
      Necrosis                                         6 (12%)      3 (6%)       1 (2%)       3 (6%)                                
      Vacuolization Cytoplasmic                                                  1 (2%)       2 (4%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                                         1 (2%)                                
   Mesentery                                          (4)          (2)          (6)          (8)                                    
      Fat, Necrosis                                    4 (100%)     2 (100%)     6 (100%)     8 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Acinus, Atrophy                                  3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Duct, Cyst                                       2 (4%)                                                                       
      Duct, Hemorrhage                                 1 (2%)                                                                       
      Duct, Inflammation, Chronic                      1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Metaplasia, Squamous                                                                    1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Squamous                            4 (8%)       3 (6%)                    2 (4%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Inflammation, Acute                                   1 (2%)                                                          
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Erosion                                          3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Metaplasia, Squamous                             1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Glands, Hyperplasia                                           1 (2%)                                                          
   Tooth                                              (4)          (3)          (4)          (7)                                    
      Degeneration                                     4 (100%)     3 (100%)     4 (100%)     7 (100%)                              
      Inflammation, Chronic Active                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 (12%)      2 (4%)       2 (4%)       2 (4%)                                
      Mineralization                                   2 (4%)                                                                       
      Atrium, Thrombosis                                                                      1 (2%)                                
      Valve, Inflammation, Acute                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                                                2 (4%)                                             
      Hypertrophy, Focal                              18 (36%)     25 (50%)     21 (42%)     17 (34%)                               
      Capsule, Hyperplasia                            39 (78%)     42 (84%)     38 (76%)     38 (76%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     48 (96%)     47 (94%)     45 (90%)     47 (94%)                               
   Pituitary Gland                                    (50)         (49)         (49)         (47)                                   
      Pars Distalis, Cyst                              2 (4%)       3 (6%)       2 (4%)                                             
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                 3 (6%)                                
      Follicular Cell, Hyperplasia                     6 (12%)      9 (18%)      3 (6%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       3 (6%)                    3 (6%)                                
      Spermatocele                                                  2 (4%)       1 (2%)                                             
   Penis                                                                        (2)                                                 
      Congestion                                                                 1 (50%)                                            
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                    1 (2%)                                
      Cyst                                            30 (60%)     33 (66%)     26 (52%)     30 (60%)                               
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       7 (14%)      5 (10%)      5 (10%)                               
      Inflammation, Chronic Active                     6 (12%)      6 (12%)      4 (8%)       7 (14%)                               
      Pigmentation                                     1 (2%)                                                                       
   Prostate                                           (50)         (50)         (49)         (50)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       1 (2%)                    3 (6%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Hypertrophy                                                   1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            3 (6%)       9 (18%)      8 (16%)      1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                                                          1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Germinal Epithelium, Degeneration                             1 (2%)       1 (2%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Mast Cell                                        1 (2%)                                                          
      Myeloid Cell, Hyperplasia                                     2 (4%)                                                          
   Lymph Node                                         (4)          (5)          (2)          (3)                                    
      Infiltration Cellular, Plasma Cell                            1 (20%)                                                         
      Iliac, Infiltration Cellular, Plasma Cell                     1 (20%)                                                         
      Iliac, Infiltration Cellular, Histiocyte         1 (25%)                                                                      
      Iliac, Pigmentation                              3 (75%)      1 (20%)                                                         
      Inguinal, Hyperplasia, Lymphoid                               1 (20%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                                         1 (50%)                                            
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      1 (20%)                                                         
      Mediastinal, Pigmentation                        1 (25%)                                                                      
      Renal, Angiectasis                                            1 (20%)                                                         
      Renal, Hyperplasia, Lymphoid                                               1 (50%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
      Angiectasis                                      7 (14%)      8 (16%)      3 (6%)       5 (10%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                 9 (18%)      8 (16%)      5 (10%)      6 (12%)                               
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)                                                          
      Lymphoid Follicle, Atrophy                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Epidermis, Cyst                                  1 (2%)                                                                       
      Epidermis, Necrosis                                                        1 (2%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                               1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Acute                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Callus                                                        1 (2%)                                                          
      Fibrous Osteodystrophy                                                                  1 (2%)                                
      Hyperostosis                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Demyelination                                                                           1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Thalamus, Mineralization                        30 (60%)     25 (50%)     23 (46%)     26 (52%)                               
   Spinal Cord                                        (1)                                                                           
      Demyelination                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    2 (4%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Histiocyte                2 (4%)       2 (4%)       4 (8%)       5 (10%)                               
      Inflammation, Chronic                                                                   2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Leukocytosis                                                  1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 5 (10%)      5 (10%)      2 (4%)       3 (6%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Acute                              4 (8%)                                 1 (2%)                                
      Glands, Amyloid Deposition                       1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                            11 (22%)     13 (26%)     10 (20%)     15 (30%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydronephrosis                                   2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Mineralization                                                             5 (10%)      2 (4%)                                
      Nephropathy, Acute                               1 (2%)       1 (2%)       6 (12%)      1 (2%)                                
      Nephropathy, Chronic                            43 (86%)     45 (90%)     38 (76%)     46 (92%)                               
      Arteriole, Thrombosis                                                                   1 (2%)                                
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Calculus Micro Observation Only                                    1 (2%)                                             
      Renal Tubule, Hyperplasia                        4 (8%)                                 1 (2%)                                
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
   Urethra                                            (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Calculus Gross Observation                                                              1 (2%)                                
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                    3 (6%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------