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TDMS Study 05160-06 Pathology Tables

NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97
Route: DOSED WATER                                                                                                Time: 09:11:09

                                                         2 YEAR CHRONIC




       Facility:  TSI Mason Research

       Chemical CAS #:  127-00-4

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7           11           10           11                                     
    Moribund Sacrifice                                 8            7            3            5                                     
    Accidently Killed                                  3                         1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           32           36           32                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (44)         (45)         (40)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                                                                1 (3%)                                
   Intestine Large, Cecum                             (44)         (46)         (48)         (49)                                   
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (45)         (47)         (46)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid             2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Peyer's Patch, Inflammation, Acute                                                      1 (2%)                                
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (44)         (45)         (45)                                   
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                 2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Eosinophilic Focus                              29 (58%)     24 (48%)     29 (58%)     31 (62%)                               
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)       2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Leukocytosis                                     1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                              2 (4%)                    1 (2%)                                
      Necrosis                                         1 (2%)       3 (6%)       1 (2%)                                             
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic            1 (2%)       1 (2%)                                                          
      Hepatocyte, Portal, Vacuolization Cytoplasmic                                           1 (2%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                            1 (2%)                                             
      Serosa, Inflammation, Chronic Active             1 (2%)                    1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (20)         (19)         (16)         (12)                                   
      Inflammation, Chronic Active                                               1 (6%)                                             
      Fat, Necrosis                                   19 (95%)     17 (89%)     14 (88%)     11 (92%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  1 (2%)       1 (2%)                    3 (6%)                                
      Acinus, Hyperplasia                                                        1 (2%)       1 (2%)                                
      Duct, Cyst                                                    1 (2%)                    2 (4%)                                
      Serosa, Inflammation, Chronic Active                                                    1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            3 (6%)       2 (4%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                            1 (2%)       2 (4%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (48)         (50)                                   
      Erosion                                          5 (10%)      2 (4%)       2 (4%)       2 (4%)                                
      Mineralization                                                1 (2%)                                                          
      Glands, Hyperplasia                                           1 (2%)                                                          
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cardiomyopathy                                   5 (10%)      2 (4%)                    2 (4%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)       2 (4%)                                             
      Atrium, Thrombosis                               1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Capsule, Hyperplasia                            48 (96%)     50 (100%)    49 (98%)     48 (96%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                             2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     28 (56%)     30 (60%)     30 (60%)     31 (62%)                               
      Hypertrophy                                                                             1 (2%)                                
   Pituitary Gland                                    (49)         (49)         (47)         (46)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Angiectasis                       2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Pars Distalis, Cyst                                           1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                       5 (10%)      3 (6%)       8 (17%)     10 (22%)                               
      Pars Intermedia, Hemorrhage                      1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                                           1 (2%)                                                          
      Follicular Cell, Hyperplasia                    13 (26%)      6 (12%)     15 (30%)     13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (48)         (49)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Pigmentation                                     2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Angiectasis                                                   2 (4%)                    2 (4%)                                
      Cyst                                            11 (22%)      9 (18%)      9 (18%)     11 (22%)                               
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Oviduct                                            (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                    3 (6%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Cystic                             41 (82%)     46 (92%)     43 (86%)     44 (88%)                               
      Inflammation, Acute                              1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Vagina                                                                       (1)                                                 
      Fibrosis                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Depletion Cellular                                            2 (4%)                                                          
      Myelofibrosis                                                              1 (2%)                                             
   Lymph Node                                         (8)          (12)         (15)         (9)                                    
      Iliac, Angiectasis                                                         2 (13%)                                            
      Iliac, Hemorrhage                                                                       1 (11%)                               
      Iliac, Hyperplasia, Lymphoid                     2 (25%)      2 (17%)      2 (13%)                                            
      Iliac, Infiltration Cellular, Plasma Cell        1 (13%)      1 (8%)       1 (7%)                                             
      Mediastinal, Angiectasis                                                   1 (7%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hemorrhage                          1 (13%)                                                                      
      Mediastinal, Inflammation, Acute                 1 (13%)                                                                      
      Mediastinal, Pigmentation                                                               1 (11%)                               
      Renal, Angiectasis                                            1 (8%)                                                          
      Renal, Ectasia                                                1 (8%)                                                          
      Renal, Hemorrhage                                                          1 (7%)                                             
      Renal, Hyperplasia, Lymphoid                                               4 (27%)                                            
      Renal, Infiltration Cellular, Plasma Cell                                  1 (7%)                                             
   Lymph Node, Mandibular                             (50)         (49)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Infiltration Cellular, Plasma Cell               1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (48)         (47)         (49)                                   
      Angiectasis                                      1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Ectasia                                                       1 (2%)       1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                13 (27%)      9 (18%)     16 (32%)     11 (22%)                               
      Hyperplasia, Lymphoid                                         3 (6%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                 1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute         1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           8 (16%)      6 (12%)      5 (10%)      4 (8%)                                
      Hyperplasia                                                                2 (4%)                                             
   Skeletal Muscle                                                 (1)                       (2)                                    
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Demyelination                                    1 (2%)                                 1 (2%)                                
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Thalamus, Mineralization                        22 (44%)     27 (55%)     22 (44%)     22 (44%)                               
   Peripheral Nerve                                   (2)                                                                           
      Demyelination                                    1 (50%)                                                                      
   Spinal Cord                                        (2)                       (1)                                                 
      Cyst Epithelial Inclusion                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       4 (8%)       3 (6%)       6 (12%)      3 (6%)                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Infiltration Cellular, Histiocyte                4 (8%)       2 (4%)       2 (4%)       4 (8%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Thrombosis                                       1 (2%)                    1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                              1 (2%)                    1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      External Ear, Inflammation, Chronic                                                     1 (100%)                              
   Eye                                                                                       (3)                                    
      Atrophy                                                                                 1 (33%)                               
      Inflammation, Acute                                                                     1 (33%)                               
      Cornea, Inflammation, Acute                                                             1 (33%)                               
      Cornea, Necrosis                                                                        1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hydronephrosis                                   1 (2%)                    3 (6%)       1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)                    1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy, Acute                                            1 (2%)                                                          
      Nephropathy, Chronic                            16 (32%)      6 (12%)      9 (18%)     11 (22%)                               
      Pigmentation                                     1 (2%)                                                                       
      Renal Tubule, Accumulation, Hyaline Droplet      3 (6%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Dilatation                                                                1 (2%)                                
   Urinary Bladder                                    (48)         (49)         (48)         (49)                                   
      Inflammation, Acute                                                        1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8                         7            4                                     
    Natural Death                                      2            6            9            4                                     
    Accidently Killed                                                            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           44           29           39                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (49)                                   
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Intestine Large, Cecum                             (49)         (50)         (48)         (47)                                   
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (44)         (47)                                   
      Diverticulum                                     1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Clear Cell Focus                                 2 (4%)      11 (22%)      6 (12%)      3 (6%)                                
      Eosinophilic Focus                              27 (54%)     34 (68%)     33 (66%)     29 (58%)                               
      Erythrophagocytosis                                           1 (2%)                                                          
      Inflammation, Chronic                            2 (4%)       1 (2%)                    1 (2%)                                
      Mixed Cell Focus                                 2 (4%)       5 (10%)      1 (2%)       3 (6%)                                
      Necrosis                                         6 (12%)      3 (6%)       1 (2%)       3 (6%)                                
      Vacuolization Cytoplasmic                                                  1 (2%)       2 (4%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                                         1 (2%)                                
   Mesentery                                          (4)          (2)          (6)          (8)                                    
      Fat, Necrosis                                    4 (100%)     2 (100%)     6 (100%)     8 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Acinus, Atrophy                                  3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Duct, Cyst                                       2 (4%)                                                                       
      Duct, Hemorrhage                                 1 (2%)                                                                       
      Duct, Inflammation, Chronic                      1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Metaplasia, Squamous                                                                    1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Squamous                            4 (8%)       3 (6%)                    2 (4%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Inflammation, Acute                                   1 (2%)                                                          
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Erosion                                          3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Metaplasia, Squamous                             1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Glands, Hyperplasia                                           1 (2%)                                                          
   Tooth                                              (4)          (3)          (4)          (7)                                    
      Degeneration                                     4 (100%)     3 (100%)     4 (100%)     7 (100%)                              
      Inflammation, Chronic Active                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 (12%)      2 (4%)       2 (4%)       2 (4%)                                
      Mineralization                                   2 (4%)                                                                       
      Atrium, Thrombosis                                                                      1 (2%)                                
      Valve, Inflammation, Acute                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                                                2 (4%)                                             
      Hypertrophy, Focal                              18 (36%)     25 (50%)     21 (42%)     17 (34%)                               
      Capsule, Hyperplasia                            39 (78%)     42 (84%)     38 (76%)     38 (76%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     48 (96%)     47 (94%)     45 (90%)     47 (94%)                               
   Pituitary Gland                                    (50)         (49)         (49)         (47)                                   
      Pars Distalis, Cyst                              2 (4%)       3 (6%)       2 (4%)                                             
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                 3 (6%)                                
      Follicular Cell, Hyperplasia                     6 (12%)      9 (18%)      3 (6%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       3 (6%)                    3 (6%)                                
      Spermatocele                                                  2 (4%)       1 (2%)                                             
   Penis                                                                        (2)                                                 
      Congestion                                                                 1 (50%)                                            
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                    1 (2%)                                
      Cyst                                            30 (60%)     33 (66%)     26 (52%)     30 (60%)                               
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       7 (14%)      5 (10%)      5 (10%)                               
      Inflammation, Chronic Active                     6 (12%)      6 (12%)      4 (8%)       7 (14%)                               
      Pigmentation                                     1 (2%)                                                                       
   Prostate                                           (50)         (50)         (49)         (50)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       1 (2%)                    3 (6%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Hypertrophy                                                   1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            3 (6%)       9 (18%)      8 (16%)      1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                                                          1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Germinal Epithelium, Degeneration                             1 (2%)       1 (2%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Mast Cell                                        1 (2%)                                                          
      Myeloid Cell, Hyperplasia                                     2 (4%)                                                          
   Lymph Node                                         (4)          (5)          (2)          (3)                                    
      Infiltration Cellular, Plasma Cell                            1 (20%)                                                         
      Iliac, Infiltration Cellular, Plasma Cell                     1 (20%)                                                         
      Iliac, Infiltration Cellular, Histiocyte         1 (25%)                                                                      
      Iliac, Pigmentation                              3 (75%)      1 (20%)                                                         
      Inguinal, Hyperplasia, Lymphoid                               1 (20%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                                         1 (50%)                                            
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      1 (20%)                                                         
      Mediastinal, Pigmentation                        1 (25%)                                                                      
      Renal, Angiectasis                                            1 (20%)                                                         
      Renal, Hyperplasia, Lymphoid                                               1 (50%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
      Angiectasis                                      7 (14%)      8 (16%)      3 (6%)       5 (10%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                 9 (18%)      8 (16%)      5 (10%)      6 (12%)                               
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)                                                          
      Lymphoid Follicle, Atrophy                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Epidermis, Cyst                                  1 (2%)                                                                       
      Epidermis, Necrosis                                                        1 (2%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                               1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Acute                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Callus                                                        1 (2%)                                                          
      Fibrous Osteodystrophy                                                                  1 (2%)                                
      Hyperostosis                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Demyelination                                                                           1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Thalamus, Mineralization                        30 (60%)     25 (50%)     23 (46%)     26 (52%)                               
   Spinal Cord                                        (1)                                                                           
      Demyelination                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    2 (4%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Histiocyte                2 (4%)       2 (4%)       4 (8%)       5 (10%)                               
      Inflammation, Chronic                                                                   2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05160-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:11:09  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Leukocytosis                                                  1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 5 (10%)      5 (10%)      2 (4%)       3 (6%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Acute                              4 (8%)                                 1 (2%)                                
      Glands, Amyloid Deposition                       1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                            11 (22%)     13 (26%)     10 (20%)     15 (30%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydronephrosis                                   2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Mineralization                                                             5 (10%)      2 (4%)                                
      Nephropathy, Acute                               1 (2%)       1 (2%)       6 (12%)      1 (2%)                                
      Nephropathy, Chronic                            43 (86%)     45 (90%)     38 (76%)     46 (92%)                               
      Arteriole, Thrombosis                                                                   1 (2%)                                
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Calculus Micro Observation Only                                    1 (2%)                                             
      Renal Tubule, Hyperplasia                        4 (8%)                                 1 (2%)                                
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
   Urethra                                            (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Calculus Gross Observation                                                              1 (2%)                                
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                    3 (6%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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