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TDMS Study 05160-06 Pathology Tables

NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97
Route: DOSED WATER                                                                                                Time: 09:05:21

                                                         2 YEAR CHRONIC




       Facility:  TSI Mason Research

       Chemical CAS #:  127-00-4

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7           11           10           11                                     
    Moribund Sacrifice                                 8            7            3            5                                     
    Accidently Killed                                  3                         1            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           32           36           32                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
   Gallbladder                                        (42)         (44)         (45)         (40)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Large, Cecum                             (44)         (46)         (48)         (49)                                   
   Intestine Small, Duodenum                          (43)         (46)         (46)         (47)                                   
   Intestine Small, Jejunum                           (46)         (45)         (47)         (46)                                   
      Carcinoma                                        1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                           1 (2%)                                             
   Intestine Small, Ileum                             (46)         (44)         (45)         (45)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                      1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                    1 (2%)       1 (2%)                                
      Hepatoblastoma                                                1 (2%)       1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma                         6 (12%)      9 (18%)      7 (14%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple                                         2 (4%)       1 (2%)                                
      Hepatocellular Adenoma                          12 (24%)     12 (24%)     10 (20%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                28 (56%)     27 (54%)     32 (64%)     30 (60%)                               
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)                                             
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                           1 (2%)                                             
      Lipoma                                                        1 (2%)                                                          
   Mesentery                                          (20)         (19)         (16)         (12)                                   

                                                             Page   2                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Carcinoma, Metastatic, Uncertain Primary Site                 2 (11%)                                                         
      Carcinoma, Metastatic, Urinary Bladder                                     1 (6%)                                             
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                      1 (5%)                                                                       
      Hemangioma                                                    1 (5%)                                                          
      Hemangiosarcoma, Metastatic, Uterus              1 (5%)                                                                       
      Histiocytic Sarcoma                              1 (5%)                    1 (6%)                                             
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                 2 (4%)                                                          
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                           1 (2%)                                             
      Acinus, Adenoma                                               1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (48)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (49)         (47)         (46)                                   
      Pars Distalis, Adenoma                           6 (12%)      5 (10%)      3 (6%)       4 (9%)                                
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)       1 (2%)                                             

                                                             Page   3                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)          (1)          (2)                                                 
      Histiocytic Sarcoma                              1 (33%)                                                                      
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                           1 (50%)                                            
      Pelvic, Hemangiosarcoma                          1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (48)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Cystadenoma                                      1 (2%)                    1 (2%)       2 (4%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                                                            1 (2%)                                
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       2 (4%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       2 (4%)                                             
      Polyp Stromal                                    1 (2%)       2 (4%)       1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Lymph Node                                         (8)          (12)         (15)         (9)                                    
      Histiocytic Sarcoma                              1 (13%)                                                                      
      Deep Cervical, Histiocytic Sarcoma               1 (13%)                                                                      
      Iliac, Hemangiosarcoma                                        1 (8%)                                                          
      Iliac, Hemangiosarcoma, Metastatic, Uterus       1 (13%)                                                                      
      Iliac, Histiocytic Sarcoma                       2 (25%)      1 (8%)                                                          
      Inguinal, Histiocytic Sarcoma                    1 (13%)                                                                      
      Mediastinal, Histiocytic Sarcoma                 1 (13%)      1 (8%)                                                          
      Pancreatic, Fibrous Histiocytoma, Metastatic,                                                                                 
           Uncertain Primary Site                                                1 (7%)                                             
      Pancreatic, Histiocytic Sarcoma                  1 (13%)                                                                      
      Renal, Histiocytic Sarcoma                       1 (13%)                   1 (7%)                                             

                                                             Page   4                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (50)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (48)         (47)         (49)                                   
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)                                             
      Leiomyosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                                           1 (2%)                                             
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (48)         (48)         (45)         (49)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                       (2)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (50%)                               
      Sarcoma, Metastatic, Skin                                                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   5                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (2%)       4 (8%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      1 (2%)       2 (4%)       3 (6%)                                
      Carcinoma, Metastatic, Harderian Gland           2 (4%)       1 (2%)                                                          
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Urinary Bladder                                     1 (2%)                                             
      Hemangiosarcoma, Metastatic, Uterus              1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       4 (8%)       3 (6%)       1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (3)          (2)          (1)                                    
      Adenoma                                          3 (60%)      1 (33%)      1 (50%)                                            
      Carcinoma                                        2 (40%)      2 (67%)      1 (50%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (48)         (49)         (48)         (49)                                   
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)                                             
      Lymphoma Malignant                              10 (20%)     14 (28%)     10 (20%)     11 (22%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          49          46          44                                       
     Total Primary Neoplasms                           94          95          86          84                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          43          43          41                                       
     Total Benign Neoplasms                            60          57          55          52                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          30          25          22                                       
     Total Malignant Neoplasms                         34          38          31          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           6           6           3                                       
     Total Metastatic Neoplasm                         14          17          24           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           2           2                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8                         7            4                                     
    Natural Death                                      2            6            9            4                                     
    Accidently Killed                                                            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           44           29           39                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (45)         (42)         (47)                                   
      Adenoma                                                       1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
   Intestine Large, Cecum                             (49)         (50)         (48)         (47)                                   
   Intestine Small, Duodenum                          (49)         (49)         (47)         (47)                                   
   Intestine Small, Jejunum                           (49)         (49)         (44)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)                    1 (2%)       2 (4%)                                
      Hemangiosarcoma, Multiple                        1 (2%)                    1 (2%)                                             
      Hepatoblastoma                                   6 (12%)      2 (4%)                    6 (12%)                               
      Hepatoblastoma, Multiple                                      1 (2%)                                                          
      Hepatocellular Carcinoma                        12 (24%)      6 (12%)      5 (10%)      7 (14%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           7 (14%)     13 (26%)     21 (42%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                28 (56%)     22 (44%)     13 (26%)     19 (38%)                               
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Mast Cell Tumor Benign                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Capsule, Adenoma                                              1 (2%)       2 (4%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                 2 (4%)                                
   Pituitary Gland                                    (50)         (49)         (49)         (47)                                   
      Pars Distalis, Adenoma                                        1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Prostate                                           (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)       1 (2%)                                
   Lymph Node                                         (4)          (5)          (2)          (3)                                    
      Fibrous Histiocytoma                                          1 (20%)                                                         
      Iliac, Fibrous Histiocytoma                                   1 (20%)                                                         
      Mediastinal, Fibrous Histiocytoma                             1 (20%)                                                         
      Pancreatic, Fibrous Histiocytoma                              1 (20%)                                                         
      Renal, Fibrous Histiocytoma                                   1 (20%)                   1 (33%)                               

                                                             Page   9                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                    1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (37)         (47)         (45)         (41)                                   
      Thymoma Benign                                                1 (2%)                                                          
      Thymoma Malignant                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                       (1)                                    
      Hemangiosarcoma                                               1 (100%)                                                        
      Sarcoma                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    11 (22%)      5 (10%)      4 (8%)       4 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       3 (6%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       2 (4%)       4 (8%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          

                                                             Page  10                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      2 (4%)       1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (5)          (3)          (1)                                    
      Adenoma                                          1 (100%)     4 (80%)      2 (67%)      1 (100%)                              
      Carcinoma                                        1 (100%)     1 (20%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
      Lymphoma Malignant                               1 (2%)       1 (2%)                    4 (8%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05160-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        1-CHLORO-2-PROPANOL                                    Date: 07/30/97  
Route: DOSED WATER                                                                                                Time: 09:05:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          44          40          42                                       
     Total Primary Neoplasms                           90          80          65          75                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          39          36          34                                       
     Total Benign Neoplasms                            53          52          47          43                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          17          15          24                                       
     Total Malignant Neoplasms                         37          28          18          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           4           2           3                                       
     Total Metastatic Neoplasm                          8           7           4           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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