Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/2600

TDMS Study 05160-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97

EXPERIMENT: 05160 TEST: 06                                                                                     TIME: 09:06:57
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C
PATHOLOGIST: F. VOELKER                                                                                        CAS: 127-00-4
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97     
EXPERIMENT: 05160 TEST: 06                                                                                     TIME: 09:06:57     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C     
PATHOLOGIST: F. VOELKER                                                                                        CAS: 127-00-4      


SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF          1-CHLORO-2-PROPANOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Liver                                  Hepatoblastoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
Lung                                   Alveolar/Bronchiolar Adenoma
All Organs                             Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
===============================================================
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         5.3%         4.5%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    1/44 (2%)    2/29 (7%)    1/39 (3%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      543         |---          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.151      P=0.519      P=0.171      P=0.242     |P=0.566N     P=0.500      (e)          (e)          |
|POLY 3             |     P=0.164      P=0.548      P=0.251      P=0.265     |P=0.627N     P=0.548      (e)          (e)          |
|POLY 1.5           |     P=0.163      P=0.531      P=0.244      P=0.255     |P=0.608N     P=0.532      (e)          (e)          |
|POLY 6             |     P=0.166      P=0.564      P=0.261      P=0.275     |P=0.650N     P=0.571      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.157      P=0.519      P=0.171      P=0.241     |(e)          P=0.500      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.160      P=0.500      P=0.247      P=0.247     |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    2/50 (4%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         8.4%         5.3%         2.3%        |6.7%         2.3%         2.3%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    4/44 (9%)    2/29 (7%)    1/39 (3%)   |2/32 (6%)    1/32 (3%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |587          735 (T)      655          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.445N     P=0.209      P=0.388      P=0.756     |P=0.077N     P=0.310N     P=0.303N     P=0.128N     |
|POLY 3             |     P=0.428N     P=0.211      P=0.494      P=0.786     |P=0.089N     P=0.333N     P=0.341N     P=0.156N     |
|POLY 1.5           |     P=0.420N     P=0.200      P=0.493      P=0.777     |P=0.085N     P=0.318N     P=0.330N     P=0.144N     |
|POLY 6             |     P=0.440N     P=0.222      P=0.497      P=0.794     |P=0.093N     P=0.354N     P=0.355N     P=0.171N     |
|LOGISTIC REGRESSION|     P=0.445N     P=0.209      P=0.388      P=0.756     |P=0.073N     P=0.304N     P=0.303N     P=0.122N     |
|COCH-ARM / FISHERS |     P=0.404N     P=0.181      P=0.500      P=0.753N    |P=0.073N     P=0.309N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         2.6%         0.0%        |4.5%         4.5%         2.3%         2.4%         |
|TERMINAL (d)       |     1/40 (3%)    1/44 (2%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    1/32 (3%)    1/36 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      608          ---         |657          647          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.333N     P=0.740N     P=0.704      P=0.505N    |P=0.353N     P=0.686      P=0.492N     P=0.520N     |
|POLY 3             |     P=0.339N     P=0.765N     P=0.774      P=0.551N    |P=0.382N     P=0.713      P=0.544N     P=0.566N     |
|POLY 1.5           |     P=0.330N     P=0.763N     P=0.767      P=0.534N    |P=0.370N     P=0.703N     P=0.530N     P=0.546N     |
|POLY 6             |     P=0.350N     P=0.768N     P=0.782      P=0.572N    |P=0.396N     P=0.717      P=0.562N     P=0.588N     |
|LOGISTIC REGRESSION|     P=0.315N     P=0.740N     P=0.759      (e)         |P=0.354N     P=0.694      P=0.507N     P=0.519N     |
|COCH-ARM / FISHERS |     P=0.311N     P=0.753N     P=0.753N     P=0.500N    |P=0.337N     P=0.691N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    1/50 (2%)   |5/50 (10%)   3/50 (6%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         10.5%        7.9%         2.3%        |11.0%        6.7%         4.6%         2.4%         |
|TERMINAL (d)       |     1/40 (3%)    5/44 (11%)   2/29 (7%)    1/39 (3%)   |3/32 (9%)    2/32 (6%)    1/36 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      608          729 (T)     |587          647          655          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.414N     P=0.126      P=0.212      P=0.756     |P=0.072N     P=0.367N     P=0.215N     P=0.117N     |
|POLY 3             |     P=0.393N     P=0.125      P=0.288      P=0.786     |P=0.082N     P=0.380N     P=0.248N     P=0.138N     |
|POLY 1.5           |     P=0.386N     P=0.117      P=0.290      P=0.777     |P=0.078N     P=0.365N     P=0.238N     P=0.126N     |
|POLY 6             |     P=0.404N     P=0.133      P=0.286      P=0.794     |P=0.088N     P=0.402N     P=0.261N     P=0.152N     |
|LOGISTIC REGRESSION|     P=0.399N     P=0.126      P=0.254      P=0.756     |P=0.068N     P=0.356N     P=0.218N     P=0.110N     |
|COCH-ARM / FISHERS |     P=0.371N     P=0.102      P=0.309      P=0.753N    |P=0.064N     P=0.357N     P=0.218N     P=0.102N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         4.5%        |2.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    0/44 (0%)    0/29 (0%)    1/39 (3%)   |1/32 (3%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          645         |735 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.234      P=0.481N     P=0.564N     P=0.494     |P=0.302N     P=0.500N     P=0.477N     P=0.500N     |
|POLY 3             |     P=0.244      P=0.521N     P=0.627N     P=0.528     |P=0.350N     P=0.550N     P=0.561N     P=0.580N     |
|POLY 1.5           |     P=0.244      P=0.514N     P=0.586N     P=0.518     |P=0.337N     P=0.529N     P=0.541N     P=0.556N     |
|POLY 6             |     P=0.244      P=0.530N     P=0.672N     P=0.538     |P=0.367N     P=0.581N     P=0.587N     P=0.611N     |
|LOGISTIC REGRESSION|     P=0.241      (e)          (e)          P=0.499     |P=0.302N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.6%         0.0%         5.3%         4.5%        |2.2%         0.0%         2.3%         2.4%         |
|TERMINAL (d)       |     2/40 (5%)    0/44 (0%)    1/29 (3%)    2/39 (5%)   |1/32 (3%)    0/32 (0%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     501          ---          602          729 (T)     |735 (T)      ---          735 (T)      734          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.596      P=0.111N     P=0.609N     P=0.509N    |P=0.546      P=0.500N     P=0.736N     P=0.757N     |
|POLY 3             |     P=0.613      P=0.119N     P=0.620N     P=0.532N    |P=0.548      P=0.550N     P=0.784      P=0.780      |
|POLY 1.5           |     P=0.604N     P=0.119N     P=0.584N     P=0.521N    |P=0.542      P=0.529N     P=0.776      P=0.773      |
|POLY 6             |     P=0.608      P=0.120N     P=0.657N     P=0.545N    |P=0.558      P=0.581N     P=0.795      P=0.791      |
|LOGISTIC REGRESSION|     P=0.578N     P=0.140N     P=0.502N     P=0.500N    |P=0.529      (e)          P=0.736N     P=0.749      |
|COCH-ARM / FISHERS |     P=0.577N     P=0.121N     P=0.500N     P=0.500N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    0/50 (0%)    6/50 (12%)  |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     13.1%        6.3%         0.0%         13.3%       |0.0%         2.3%         2.3%         2.4%         |
|TERMINAL (d)       |     4/40 (10%)   3/44 (7%)    0/29 (0%)    4/39 (10%)  |0/32 (0%)    1/32 (3%)    1/36 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     518          729 (T)      ---          568         |---          735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.472      P=0.206N     P=0.039N*    P=0.609     |P=0.386      P=0.500      P=0.523      P=0.500      |
|POLY 3             |     P=0.483      P=0.231N     P=0.037N*    P=0.621     |P=0.386      P=0.548      P=0.549      P=0.551      |
|POLY 1.5           |     P=0.494      P=0.234N     P=0.028N*    P=0.621     |P=0.384      P=0.532      P=0.533      P=0.534      |
|POLY 6             |     P=0.472      P=0.230N     P=0.049N*    P=0.620     |P=0.392      P=0.571      P=0.572      P=0.575      |
|LOGISTIC REGRESSION|     P=0.511      P=0.262N     P=0.017N*    P=0.619N    |(e)          P=0.500      P=0.523      P=0.500      |
|COCH-ARM / FISHERS |     P=0.518      P=0.243N     P=0.013N*    P=0.620N    |P=0.384      P=0.500      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     35/50 (70%)  35/50 (70%)  34/50 (68%)  30/50 (60%) |40/50 (80%)  39/50 (78%)  42/50 (84%)  40/50 (80%)  |
|POLY-3 ADJUSTED (b)|     76.0%        72.9%        79.6%        65.1%       |85.2%        82.3%        92.4%        88.7%        |
|TERMINAL (d)       |     32/40 (80%)  33/44 (75%)  23/29 (79%)  25/39 (64%) |29/32 (91%)  27/32 (84%)  36/36 (100%) 29/32 (91%)  |
|FIRST INCIDENCE    |     464          645          377          556         |587          449          543          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.356N     P=0.306N     P=0.055      P=0.253N    |P=0.446      P=0.533N     P=0.468N     P=0.498      |
|POLY 3             |     P=0.151N     P=0.460N     P=0.451      P=0.176N    |P=0.237      P=0.465N     P=0.211      P=0.430      |
|POLY 1.5           |     P=0.155N     P=0.503N     P=0.479      P=0.189N    |P=0.271      P=0.428N     P=0.270      P=0.461      |
|POLY 6             |     P=0.144N     P=0.416N     P=0.436      P=0.161N    |P=0.213      P=0.534N     P=0.134      P=0.405      |
|LOGISTIC REGRESSION|     P=0.195N     P=0.378N     P=0.304      P=0.193N    |P=0.183      P=0.473N     P=0.244      P=0.354      |
|COCH-ARM / FISHERS |     P=0.143N     P=0.586N     P=0.500N     P=0.201N    |P=0.488      P=0.500N     P=0.398      P=0.598N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  6/50 (12%)   6/50 (12%)   8/50 (16%)  |6/50 (12%)   9/50 (18%)   9/50 (18%)   10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     29.0%        12.2%        15.0%        17.7%       |13.4%        19.4%        20.3%        23.4%        |
|TERMINAL (d)       |     12/40 (30%)  4/44 (9%)    1/29 (3%)    4/39 (10%)  |4/32 (13%)   3/32 (9%)    5/36 (14%)   7/32 (22%)   |
|FIRST INCIDENCE    |     646          335          458          617         |726          575          645          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.261N     P=0.044N*    P=0.204N     P=0.187N    |P=0.188      P=0.287      P=0.334      P=0.199      |
|POLY 3             |     P=0.228N     P=0.038N*    P=0.109N     P=0.159N    |P=0.168      P=0.326      P=0.294      P=0.186      |
|POLY 1.5           |     P=0.219N     P=0.044N*    P=0.096N     P=0.162N    |P=0.173      P=0.318      P=0.289      P=0.189      |
|POLY 6             |     P=0.236N     P=0.034N*    P=0.123N     P=0.157N    |P=0.166      P=0.339      P=0.305      P=0.188      |
|LOGISTIC REGRESSION|     P=0.189N     P=0.070N     P=0.086N     P=0.165N    |P=0.185      P=0.285      P=0.270      P=0.173      |
|COCH-ARM / FISHERS |     P=0.192N     P=0.062N     P=0.062N     P=0.163N    |P=0.204      P=0.288      P=0.288      P=0.207      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  9/50 (18%)   6/50 (12%)   13/50 (26%) |6/50 (12%)   10/50 (20%)  10/50 (20%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     39.0%        18.3%        15.0%        28.4%       |13.4%        21.5%        22.5%        23.4%        |
|TERMINAL (d)       |     15/40 (38%)  7/44 (16%)   1/29 (3%)    8/39 (21%)  |4/32 (13%)   4/32 (13%)   6/36 (17%)   7/32 (22%)   |
|FIRST INCIDENCE    |     518          335          458          568         |726          575          645          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.318N     P=0.024N*    P=0.042N*    P=0.227N    |P=0.211      P=0.210      P=0.254      P=0.199      |
|POLY 3             |     P=0.280N     P=0.020N*    P=0.012N*    P=0.199N    |P=0.186      P=0.239      P=0.210      P=0.186      |
|POLY 1.5           |     P=0.267N     P=0.023N*    P=0.009N**   P=0.199N    |P=0.192      P=0.232      P=0.206      P=0.189      |
|POLY 6             |     P=0.291N     P=0.019N*    P=0.017N*    P=0.200N    |P=0.184      P=0.250      P=0.219      P=0.188      |
|LOGISTIC REGRESSION|     P=0.229N     P=0.044N*    P=0.007N**   P=0.196N    |P=0.204      P=0.206      P=0.190      P=0.173      |
|COCH-ARM / FISHERS |     P=0.230N     P=0.035N*    P=0.005N**   P=0.194N    |P=0.228      P=0.207      P=0.207      P=0.207      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     39/50 (78%)  38/50 (76%)  37/50 (74%)  32/50 (64%) |41/50 (82%)  41/50 (82%)  43/50 (86%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     84.2%        76.5%        83.8%        69.0%       |87.3%        85.1%        93.9%        92.7%        |
|TERMINAL (d)       |     35/40 (88%)  34/44 (77%)  23/29 (79%)  26/39 (67%) |29/32 (91%)  27/32 (84%)  36/36 (100%) 30/32 (94%)  |
|FIRST INCIDENCE    |     464          335          377          556         |587          449          543          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.250N     P=0.217N     P=0.064      P=0.145N    |P=0.384      P=0.534      P=0.471N     P=0.419      |
|POLY 3             |     P=0.068N     P=0.247N     P=0.608N     P=0.064N    |P=0.140      P=0.503N     P=0.219      P=0.301      |
|POLY 1.5           |     P=0.068N     P=0.318N     P=0.610N     P=0.074N    |P=0.173      P=0.494N     P=0.268      P=0.330      |
|POLY 6             |     P=0.064N     P=0.198N     P=0.584N     P=0.055N    |P=0.121      P=0.530N     P=0.154      P=0.287      |
|LOGISTIC REGRESSION|     P=0.080N     P=0.373N     P=0.401      P=0.081N    |P=0.115      P=0.560N     P=0.235      P=0.222      |
|COCH-ARM / FISHERS |     P=0.059N     P=0.500N     P=0.408N     P=0.093N    |P=0.411      P=0.602N     P=0.393      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     40/50 (80%)  39/50 (78%)  37/50 (74%)  36/50 (72%) |41/50 (82%)  41/50 (82%)  43/50 (86%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     85.3%        78.6%        83.8%        77.6%       |87.3%        85.1%        93.9%        92.7%        |
|TERMINAL (d)       |     35/40 (88%)  35/44 (80%)  23/29 (79%)  30/39 (77%) |29/32 (91%)  27/32 (84%)  36/36 (100%) 30/32 (94%)  |
|FIRST INCIDENCE    |     464          335          377          556         |587          449          543          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.474N     P=0.214N     P=0.093      P=0.325N    |P=0.384      P=0.534      P=0.471N     P=0.419      |
|POLY 3             |     P=0.271N     P=0.277N     P=0.549N     P=0.245N    |P=0.140      P=0.503N     P=0.219      P=0.301      |
|POLY 1.5           |     P=0.251N     P=0.335N     P=0.533N     P=0.247N    |P=0.173      P=0.494N     P=0.268      P=0.330      |
|POLY 6             |     P=0.280N     P=0.242N     P=0.548N     P=0.242N    |P=0.121      P=0.530N     P=0.154      P=0.287      |
|LOGISTIC REGRESSION|     P=0.243N     P=0.389N     P=0.524      P=0.229N    |P=0.115      P=0.560N     P=0.235      P=0.222      |
|COCH-ARM / FISHERS |     P=0.185N     P=0.500N     P=0.318N     P=0.241N    |P=0.411      P=0.602N     P=0.393      P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  8/50 (16%)   4/50 (8%)    5/50 (10%)  |4/50 (8%)    1/50 (2%)    4/50 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     26.3%        16.8%        10.5%        11.2%       |9.0%         2.3%         9.1%         9.5%         |
|TERMINAL (d)       |     10/40 (25%)  8/44 (18%)   3/29 (10%)   4/39 (10%)  |3/32 (9%)    1/32 (3%)    2/36 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     220          729 (T)      511          568         |733          735 (T)      645          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.051N     P=0.167N     P=0.101N     P=0.065N    |P=0.398      P=0.183N     P=0.608N     P=0.640N     |
|POLY 3             |     P=0.040N*    P=0.199N     P=0.067N     P=0.059N    |P=0.388      P=0.195N     P=0.653      P=0.634      |
|POLY 1.5           |     P=0.037N*    P=0.210N     P=0.053N     P=0.058N    |P=0.387      P=0.186N     P=0.647      P=0.634      |
|POLY 6             |     P=0.043N*    P=0.189N     P=0.087N     P=0.061N    |P=0.393      P=0.210N     P=0.661      P=0.637      |
|LOGISTIC REGRESSION|     P=0.035N*    P=0.220N     P=0.038N*    P=0.055N    |P=0.383      P=0.194N     P=0.631      P=0.623      |
|COCH-ARM / FISHERS |     P=0.031N*    P=0.227N     P=0.027N*    P=0.054N    |P=0.404      P=0.181N     P=0.643N     P=0.643N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    5/50 (10%)   4/50 (8%)   |5/50 (10%)   1/50 (2%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     9.0%         6.3%         13.0%        8.9%        |10.8%        2.2%         4.6%         7.1%         |
|TERMINAL (d)       |     4/40 (10%)   2/44 (5%)    2/29 (7%)    3/39 (8%)   |1/32 (3%)    0/32 (0%)    2/36 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     729 (T)      710          519          543         |465          710          735 (T)      466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.450      P=0.449N     P=0.328      P=0.634     |P=0.411N     P=0.120N     P=0.208N     P=0.382N     |
|POLY 3             |     P=0.487      P=0.477N     P=0.438      P=0.656N    |P=0.435N     P=0.120N     P=0.259N     P=0.429N     |
|POLY 1.5           |     P=0.490      P=0.484N     P=0.451      P=0.652N    |P=0.427N     P=0.110N     P=0.245N     P=0.407N     |
|POLY 6             |     P=0.482      P=0.470N     P=0.424      P=0.663N    |P=0.444N     P=0.133N     P=0.278N     P=0.454N     |
|LOGISTIC REGRESSION|     P=0.486      P=0.451N     P=0.424      P=0.641     |P=0.368N     P=0.122N     P=0.206N     P=0.318N     |
|COCH-ARM / FISHERS |     P=0.500      P=0.500N     P=0.500      P=0.643N    |P=0.397N     P=0.102N     P=0.218N     P=0.357N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/50 (32%)  11/50 (22%)  9/50 (18%)   9/50 (18%)  |9/50 (18%)   2/50 (4%)    5/50 (10%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     35.1%        23.1%        23.0%        19.8%       |19.4%        4.5%         11.4%        14.2%        |
|TERMINAL (d)       |     14/40 (35%)  10/44 (23%)  5/29 (17%)   7/39 (18%)  |4/32 (13%)   1/32 (3%)    3/36 (8%)    4/32 (13%)   |
|FIRST INCIDENCE    |     220          710          511          543         |465          710          645          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.123N     P=0.296N     P=0.098N    |P=0.426N     P=0.036N*    P=0.182N     P=0.310N     |
|POLY 3             |     P=0.087N     P=0.150N     P=0.177N     P=0.084N    |P=0.461N     P=0.032N*    P=0.233N     P=0.373N     |
|POLY 1.5           |     P=0.084N     P=0.163N     P=0.149N     P=0.085N    |P=0.451N     P=0.028N*    P=0.220N     P=0.347N     |
|POLY 6             |     P=0.091N     P=0.138N     P=0.208N     P=0.083N    |P=0.470N     P=0.038N*    P=0.246N     P=0.402N     |
|LOGISTIC REGRESSION|     P=0.082N     P=0.161N     P=0.126N     P=0.084N    |P=0.416N     P=0.029N*    P=0.192N     P=0.289N     |
|COCH-ARM / FISHERS |     P=0.072N     P=0.184N     P=0.083N     P=0.083N    |P=0.409N     P=0.026N*    P=0.194N     P=0.288N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    0/49 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.2%         0.0%         2.3%         4.8%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    0/32 (0%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      ---          735 (T)      642          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.235      P=0.500N     P=0.736N     P=0.475      |
|POLY 3             |                                                        |P=0.255      P=0.550N     P=0.784      P=0.515      |
|POLY 1.5           |                                                        |P=0.251      P=0.531N     P=0.776      P=0.508      |
|POLY 6             |                                                        |P=0.262      P=0.578N     P=0.795      P=0.527      |
|LOGISTIC REGRESSION|                                                        |P=0.240      (e)          P=0.736N     P=0.495      |
|COCH-ARM / FISHERS |                                                        |P=0.249      P=0.505N     P=0.753N     P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/49 (0%)    0/47 (0%)   |6/49 (12%)   5/49 (10%)   3/47 (6%)    4/46 (9%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         0.0%        |13.6%        11.4%        7.3%         10.5%        |
|TERMINAL (d)       |     0/40 (0%)    1/43 (2%)    0/29 (0%)    0/37 (0%)   |5/32 (16%)   4/32 (13%)   3/35 (9%)    4/30 (13%)   |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |733          695          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.587N     P=0.514      (e)          (e)         |P=0.304N     P=0.502N     P=0.200N     P=0.406N     |
|POLY 3             |     P=0.606N     P=0.544      (e)          (e)         |P=0.374N     P=0.519N     P=0.295N     P=0.487N     |
|POLY 1.5           |     P=0.595N     P=0.527      (e)          (e)         |P=0.362N     P=0.504N     P=0.286N     P=0.466N     |
|POLY 6             |     P=0.621N     P=0.560      (e)          (e)         |P=0.384N     P=0.538N     P=0.305N     P=0.507N     |
|LOGISTIC REGRESSION|     (e)          P=0.514      (e)          (e)         |P=0.364N     P=0.536N     P=0.200N     P=0.406N     |
|COCH-ARM / FISHERS |     P=0.576N     P=0.495      (e)          (e)         |P=0.318N     P=0.500N     P=0.264N     P=0.411N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |2.2%         6.8%         2.3%         4.8%         |
|TERMINAL (d)       |     1/40 (3%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    3/32 (9%)    1/36 (3%)    2/32 (6%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.322N     P=0.481N     P=0.564N     P=0.505N    |P=0.532      P=0.304      P=0.736N     P=0.500      |
|POLY 3             |     P=0.349N     P=0.521N     P=0.627N     P=0.551N    |P=0.513      P=0.326      P=0.784      P=0.513      |
|POLY 1.5           |     P=0.334N     P=0.514N     P=0.586N     P=0.534N    |P=0.515      P=0.322      P=0.776      P=0.507      |
|POLY 6             |     P=0.365N     P=0.530N     P=0.672N     P=0.572N    |P=0.514      P=0.331      P=0.795      P=0.523      |
|LOGISTIC REGRESSION|     P=0.322N     (e)          (e)          (e)         |P=0.532      P=0.304      P=0.736N     P=0.500      |
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.526      P=0.309      P=0.753N     P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |2.2%         6.8%         2.3%         4.8%         |
|TERMINAL (d)       |     1/40 (3%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    3/32 (9%)    1/36 (3%)    2/32 (6%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.322N     P=0.481N     P=0.564N     P=0.505N    |P=0.532      P=0.304      P=0.736N     P=0.500      |
|POLY 3             |     P=0.349N     P=0.521N     P=0.627N     P=0.551N    |P=0.513      P=0.326      P=0.784      P=0.513      |
|POLY 1.5           |     P=0.334N     P=0.514N     P=0.586N     P=0.534N    |P=0.515      P=0.322      P=0.776      P=0.507      |
|POLY 6             |     P=0.365N     P=0.530N     P=0.672N     P=0.572N    |P=0.514      P=0.331      P=0.795      P=0.523      |
|LOGISTIC REGRESSION|     P=0.322N     (e)          (e)          (e)         |P=0.532      P=0.304      P=0.736N     P=0.500      |
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.526      P=0.309      P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         0.0%         0.0%        |2.2%         4.5%         2.3%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    1/44 (2%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    0/32 (0%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |735 (T)      691          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.256N     P=0.740N     P=0.564N     P=0.505N    |P=0.259N     P=0.503      P=0.736N     P=0.500N     |
|POLY 3             |     P=0.264N     P=0.765N     P=0.627N     P=0.551N    |P=0.291N     P=0.528      P=0.784      P=0.580N     |
|POLY 1.5           |     P=0.255N     P=0.763N     P=0.586N     P=0.534N    |P=0.279N     P=0.521      P=0.776      P=0.556N     |
|POLY 6             |     P=0.276N     P=0.768N     P=0.672N     P=0.572N    |P=0.305N     P=0.539      P=0.795      P=0.611N     |
|LOGISTIC REGRESSION|     P=0.256N     P=0.740N     (e)          (e)         |P=0.263N     P=0.501      P=0.736N     (e)          |
|COCH-ARM / FISHERS |     P=0.236N     P=0.753N     P=0.500N     P=0.500N    |P=0.247N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         2.7%         2.3%        |2.3%         4.5%         2.3%         4.8%         |
|TERMINAL (d)       |     0/40 (0%)    1/44 (2%)    1/29 (3%)    1/39 (3%)   |1/32 (3%)    0/32 (0%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |735 (T)      691          735 (T)      664          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.363      P=0.519      P=0.436      P=0.495     |P=0.425      P=0.503      P=0.736N     P=0.487      |
|POLY 3             |     P=0.395      P=0.548      P=0.560      P=0.549     |P=0.445      P=0.536      P=0.789      P=0.522      |
|POLY 1.5           |     P=0.391      P=0.531      P=0.537      P=0.532     |P=0.444      P=0.529      P=0.780      P=0.515      |
|POLY 6             |     P=0.398      P=0.564      P=0.586      P=0.566     |P=0.449      P=0.547      P=0.799      P=0.533      |
|LOGISTIC REGRESSION|     (e)          P=0.519      P=0.436      P=0.495     |P=0.428      P=0.509      P=0.736N     P=0.487      |
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.450      P=0.508      P=0.747N     P=0.508      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.3%         0.0%        |                                                    |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    2/29 (7%)    0/39 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.574      (e)          P=0.171      (e)         |                                                    |
|POLY 3             |     P=0.616      (e)          P=0.251      (e)         |                                                    |
|POLY 1.5           |     P=0.609      (e)          P=0.244      (e)         |                                                    |
|POLY 6             |     P=0.623      (e)          P=0.261      (e)         |                                                    |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.171      (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         2.7%         2.3%        |2.2%         4.5%         2.3%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    1/44 (2%)    1/29 (3%)    1/39 (3%)   |1/32 (3%)    2/32 (6%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |735 (T)      735 (T)      735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.604      P=0.740N     P=0.688      P=0.756     |P=0.240N     P=0.500      P=0.736N     P=0.500N     |
|POLY 3             |     P=0.634      P=0.765N     P=0.774      P=0.786     |P=0.291N     P=0.527      P=0.784      P=0.580N     |
|POLY 1.5           |     P=0.633      P=0.763N     P=0.767      P=0.777     |P=0.279N     P=0.521      P=0.776      P=0.556N     |
|POLY 6             |     P=0.635      P=0.768N     P=0.782      P=0.794     |P=0.305N     P=0.536      P=0.795      P=0.611N     |
|LOGISTIC REGRESSION|     P=0.604      P=0.740N     P=0.688      P=0.756     |P=0.240N     P=0.500      P=0.736N     (e)          |
|COCH-ARM / FISHERS |     P=0.634      P=0.753N     P=0.753N     P=0.753N    |P=0.247N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.2%         4.5%         2.3%         0.0%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    1/32 (3%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      695          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.250N     P=0.500      P=0.736N     P=0.500N     |
|POLY 3             |                                                        |P=0.291N     P=0.528      P=0.784      P=0.580N     |
|POLY 1.5           |                                                        |P=0.279N     P=0.521      P=0.776      P=0.556N     |
|POLY 6             |                                                        |P=0.305N     P=0.537      P=0.795      P=0.611N     |
|LOGISTIC REGRESSION|                                                        |P=0.267N     P=0.494      P=0.736N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.247N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.5%         6.7%         2.3%         2.4%         |
|TERMINAL (d)       |                                                        |2/32 (6%)    2/32 (6%)    1/36 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      695          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.278N     P=0.500      P=0.459N     P=0.500N     |
|POLY 3             |                                                        |P=0.322N     P=0.521      P=0.542N     P=0.564N     |
|POLY 1.5           |                                                        |P=0.310N     P=0.518      P=0.529N     P=0.545N     |
|POLY 6             |                                                        |P=0.334N     P=0.526      P=0.560N     P=0.586N     |
|LOGISTIC REGRESSION|                                                        |P=0.308N     P=0.484      P=0.459N     P=0.500N     |
|COCH-ARM / FISHERS |                                                        |P=0.279N     P=0.500      P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         0.0%         0.0%        |2.2%         4.5%         2.3%         2.4%         |
|TERMINAL (d)       |     2/40 (5%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    1/32 (3%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |677          703          735 (T)      616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.130N     P=0.218N     P=0.312N     P=0.244N    |P=0.549N     P=0.494      P=0.759N     P=0.739      |
|POLY 3             |     P=0.136N     P=0.242N     P=0.338N     P=0.267N    |P=0.576N     P=0.525      P=0.782      P=0.779      |
|POLY 1.5           |     P=0.128N     P=0.240N     P=0.304N     P=0.257N    |P=0.564N     P=0.520      P=0.775      P=0.772      |
|POLY 6             |     P=0.145N     P=0.245N     P=0.378N     P=0.280N    |P=0.588N     P=0.533      P=0.792      P=0.789      |
|LOGISTIC REGRESSION|     P=0.130N     (e)          (e)          (e)         |P=0.538N     P=0.502      P=0.759      P=0.754N     |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.531N     P=0.500      P=0.753N     P=0.753N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    4/50 (8%)    4/50 (8%)   |4/50 (8%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     11.0%        6.3%         10.6%        9.0%        |8.9%         4.5%         6.9%         4.8%         |
|TERMINAL (d)       |     3/40 (8%)    3/44 (7%)    3/29 (10%)   4/39 (10%)  |3/32 (9%)    0/32 (0%)    2/36 (6%)    0/32 (0%)    |
|FIRST INCIDENCE    |     501          729 (T)      602          729 (T)     |673          691          655          664          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.554N     P=0.315N     P=0.602      P=0.517N    |P=0.345N     P=0.344N     P=0.475N     P=0.360N     |
|POLY 3             |     P=0.548N     P=0.340N     P=0.641N     P=0.531N    |P=0.365N     P=0.357N     P=0.536N     P=0.397N     |
|POLY 1.5           |     P=0.532N     P=0.345N     P=0.600N     P=0.520N    |P=0.355N     P=0.344N     P=0.525N     P=0.380N     |
|POLY 6             |     P=0.567N     P=0.337N     P=0.668      P=0.547N    |P=0.374N     P=0.375N     P=0.549N     P=0.415N     |
|LOGISTIC REGRESSION|     P=0.522N     P=0.359N     P=0.562N     P=0.502N    |P=0.343N     P=0.336N     P=0.513N     P=0.365N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.357N     P=0.500N     P=0.500N    |P=0.319N     P=0.339N     P=0.500N     P=0.339N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    4/50 (8%)    4/50 (8%)   |5/50 (10%)   3/50 (6%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     15.4%        6.3%         10.6%        9.0%        |11.1%        6.7%         9.2%         7.1%         |
|TERMINAL (d)       |     5/40 (13%)   3/44 (7%)    3/29 (10%)   4/39 (10%)  |3/32 (9%)    1/32 (3%)    3/36 (8%)    0/32 (0%)    |
|FIRST INCIDENCE    |     501          729 (T)      602          729 (T)     |673          691          655          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.336N     P=0.131N     P=0.446N     P=0.280N    |P=0.371N     P=0.367N     P=0.477N     P=0.392N     |
|POLY 3             |     P=0.324N     P=0.144N     P=0.400N     P=0.287N    |P=0.390N     P=0.377N     P=0.538N     P=0.416N     |
|POLY 1.5           |     P=0.309N     P=0.148N     P=0.357N     P=0.278N    |P=0.381N     P=0.363N     P=0.527N     P=0.400N     |
|POLY 6             |     P=0.341N     P=0.141N     P=0.449N     P=0.301N    |P=0.397N     P=0.397N     P=0.554N     P=0.431N     |
|LOGISTIC REGRESSION|     P=0.303N     P=0.152N     P=0.333N     P=0.264N    |P=0.365N     P=0.354N     P=0.514N     P=0.373N     |
|COCH-ARM / FISHERS |     P=0.279N     P=0.159N     P=0.262N     P=0.262N    |P=0.341N     P=0.357N     P=0.500N     P=0.357N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         2.1%         0.0%         0.0%        |4.5%         2.2%         4.6%         0.0%         |
|TERMINAL (d)       |     2/40 (5%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      665          ---          ---         |726          662          697          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.118N     P=0.465N     P=0.312N     P=0.244N    |P=0.218N     P=0.519N     P=0.683N     P=0.256N     |
|POLY 3             |     P=0.118N     P=0.495N     P=0.338N     P=0.267N    |P=0.239N     P=0.528N     P=0.708      P=0.294N     |
|POLY 1.5           |     P=0.112N     P=0.496N     P=0.304N     P=0.257N    |P=0.229N     P=0.514N     P=0.703      P=0.276N     |
|POLY 6             |     P=0.125N     P=0.494N     P=0.378N     P=0.280N    |P=0.250N     P=0.548N     P=0.716      P=0.315N     |
|LOGISTIC REGRESSION|     P=0.107N     P=0.492N     (e)          (e)         |P=0.212N     P=0.498N     P=0.683      P=0.259N     |
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.200N     P=0.500N     P=0.691N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    0/50 (0%)    4/50 (8%)   |12/50 (24%)  15/50 (30%)  12/50 (24%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     6.7%         4.2%         0.0%         9.0%        |26.7%        31.8%        27.4%        25.5%        |
|TERMINAL (d)       |     3/40 (8%)    1/44 (2%)    0/29 (0%)    3/39 (8%)   |8/32 (25%)   9/32 (28%)   10/36 (28%)  8/32 (25%)   |
|FIRST INCIDENCE    |     729 (T)      665          ---          617         |683          449          645          238          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.351      P=0.455N     P=0.183N     P=0.490     |P=0.371N     P=0.328      P=0.497N     P=0.522N     |
|POLY 3             |     P=0.368      P=0.483N     P=0.189N     P=0.520     |P=0.421N     P=0.388      P=0.579      P=0.556N     |
|POLY 1.5           |     P=0.373      P=0.489N     P=0.164N     P=0.512     |P=0.405N     P=0.378      P=0.581      P=0.542N     |
|POLY 6             |     P=0.362      P=0.478N     P=0.219N     P=0.526     |P=0.434N     P=0.395      P=0.578      P=0.570N     |
|LOGISTIC REGRESSION|     P=0.369      P=0.476N     (e)          P=0.496     |P=0.385N     P=0.328      P=0.548      P=0.542N     |
|COCH-ARM / FISHERS |     P=0.387      P=0.500N     P=0.121N     P=0.500     |P=0.350N     P=0.326      P=0.592N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    4/50 (8%)   |10/50 (20%)  14/50 (28%)  10/50 (20%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         0.0%         9.0%        |22.3%        29.9%        22.9%        25.5%        |
|TERMINAL (d)       |     1/40 (3%)    1/44 (2%)    0/29 (0%)    3/39 (8%)   |8/32 (25%)   9/32 (28%)   9/36 (25%)   8/32 (25%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          617         |683          449          645          238          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.057      P=0.740N     P=0.564N     P=0.177     |P=0.522N     P=0.246      P=0.502N     P=0.484      |
|POLY 3             |     P=0.057      P=0.765N     P=0.627N     P=0.194     |P=0.525      P=0.287      P=0.587      P=0.474      |
|POLY 1.5           |     P=0.058      P=0.763N     P=0.586N     P=0.188     |P=0.536      P=0.280      P=0.588      P=0.479      |
|POLY 6             |     P=0.056      P=0.768N     P=0.672N     P=0.199     |P=0.520      P=0.289      P=0.585      P=0.474      |
|LOGISTIC REGRESSION|     P=0.058      P=0.740N     (e)          P=0.178     |P=0.544N     P=0.241      P=0.559      P=0.465      |
|COCH-ARM / FISHERS |     P=0.062      P=0.753N     P=0.500N     P=0.181     |P=0.511N     P=0.241      P=0.598N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  39/50 (78%)  36/50 (72%)  34/50 (68%) |42/50 (84%)  43/50 (86%)  43/50 (86%)  41/50 (82%)  |
|POLY-3 ADJUSTED (b)|     87.1%        81.2%        84.3%        72.3%       |89.0%        89.5%        93.9%        90.5%        |
|TERMINAL (d)       |     36/40 (90%)  37/44 (84%)  25/29 (86%)  27/39 (69%) |30/32 (94%)  29/32 (91%)  36/36 (100%) 29/32 (91%)  |
|FIRST INCIDENCE    |     220          645          377          543         |587          449          543          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.243N     P=0.126N     P=0.140      P=0.150N    |P=0.489N     P=0.465      P=0.384N     P=0.564      |
|POLY 3             |     P=0.044N*    P=0.307N     P=0.485N     P=0.058N    |P=0.428      P=0.612      P=0.314      P=0.553      |
|POLY 1.5           |     P=0.055N     P=0.350N     P=0.425N     P=0.074N    |P=0.468      P=0.629      P=0.376      P=0.583      |
|POLY 6             |     P=0.031N*    P=0.258N     P=0.527N     P=0.041N*   |P=0.402      P=0.559      P=0.221      P=0.529      |
|LOGISTIC REGRESSION|     P=0.075N     P=0.230N     P=0.508N     P=0.079N    |P=0.351      P=0.560      P=0.353      P=0.464      |
|COCH-ARM / FISHERS |     P=0.055N     P=0.402N     P=0.171N     P=0.083N    |P=0.409N     P=0.500      P=0.500      P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 17
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/50 (64%)  17/50 (34%)  15/50 (30%)  24/50 (48%) |28/50 (56%)  30/50 (60%)  26/50 (52%)  22/50 (44%)  |
|POLY-3 ADJUSTED (b)|     66.9%        34.3%        36.2%        51.7%       |59.2%        60.4%        56.8%        49.2%        |
|TERMINAL (d)       |     26/40 (65%)  13/44 (30%)  6/29 (21%)   18/39 (46%) |17/32 (53%)  16/32 (50%)  18/36 (50%)  14/32 (44%)  |
|FIRST INCIDENCE    |     220          335          458          543         |465          449          540          238          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.307N     P=0.002N**   P=0.046N*    P=0.127N    |P=0.155N     P=0.419      P=0.332N     P=0.238N     |
|POLY 3             |     P=0.237N     P<0.001N**   P=0.003N**   P=0.098N    |P=0.162N     P=0.534      P=0.496N     P=0.231N     |
|POLY 1.5           |     P=0.219N     P<0.001N**   P=0.002N**   P=0.095N    |P=0.137N     P=0.514      P=0.478N     P=0.207N     |
|POLY 6             |     P=0.249N     P<0.001N**   P=0.004N**   P=0.099N    |P=0.191N     P=0.552      P=0.509N     P=0.258N     |
|LOGISTIC REGRESSION|     P=0.178N     P=0.004N**   P<0.001N**   P=0.080N    |P=0.101N     P=0.413      P=0.453N     P=0.190N     |
|COCH-ARM / FISHERS |     P=0.168N     P=0.002N**   P<0.001N**   P=0.079N    |P=0.082N     P=0.420      P=0.421N     P=0.159N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  44/50 (88%)  40/50 (80%)  42/50 (84%) |46/50 (92%)  49/50 (98%)  47/50 (94%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|     98.7%        88.2%        89.9%        88.8%       |95.9%        98.0%        99.7%        94.6%        |
|TERMINAL (d)       |     40/40 (100%) 39/44 (89%)  25/29 (86%)  34/39 (87%) |31/32 (97%)  31/32 (97%)  36/36 (100%) 30/32 (94%)  |
|FIRST INCIDENCE    |     220          335          377          543         |465          449          540          238          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.381N     P=0.045N*    P=0.248      P=0.188N    |P=0.384N     P=0.333      P=0.401N     P=0.520N     |
|POLY 3             |     P=0.106N     P=0.039N*    P=0.068N     P=0.048N*   |P=0.431N     P=0.499      P=0.293      P=0.587N     |
|POLY 1.5           |     P=0.094N     P=0.061N     P=0.060N     P=0.051N    |P=0.346N     P=0.443      P=0.321      P=0.533N     |
|POLY 6             |     P=0.101N     P=0.026N*    P=0.065N     P=0.039N*   |P=0.492N     P=0.529      P=0.282      P=0.627N     |
|LOGISTIC REGRESSION|     P=0.067N     P=0.097N     P=0.093N     P=0.037N*   |P=0.448N     P=0.299      P=0.355      P=0.625N     |
|COCH-ARM / FISHERS |     P=0.051N     P=0.134N     P=0.014N*    P=0.046N*   |P=0.151N     P=0.181      P=0.500      P=0.370N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).