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TDMS Study 05160-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97

EXPERIMENT: 05160 TEST: 06                                                                                     TIME: 15:09:56
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C
PATHOLOGIST: F. VOELKER                                                                                        CAS: 127-00-4
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 08/01/97     
EXPERIMENT: 05160 TEST: 06                                                                                     TIME: 15:09:56     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C     
PATHOLOGIST: F. VOELKER                                                                                        CAS: 127-00-4      


SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF          1-CHLORO-2-PROPANOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hypertrophy Focal
Kidney                                 Mineralization
                                       Nephropathy Acute
Liver                                  Clear Cell Focus
                                       Eosinophilic Focus
                                       Necrosis
Lung                                   Inflammation Chronic
Lymph Node: Iliac                      Pigmentation
Seminal Vesicle                        Inflammation Chronic
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Hyperplasia
Heart                                  Cardiomyopathy
Kidney                                 Nephropathy Chronic
Kidney: Renal Tubule                   Accumulation, Hyaline Droplet
Lymph Node: Iliac                      Hyperplasia Lymphoid
Pituitary Gland: Pars Distalis         Hyperplasia
Stomach, Forestomach                   Hyperplasia
===============================================================
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.3%         0.0%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    2/29 (7%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.574      (e)          P=0.171      (e)         |P=0.197      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.616      (e)          P=0.251      (e)         |P=0.230      (e)          (e)          P=0.551      |
|POLY 1.5           |     P=0.609      (e)          P=0.244      (e)         |P=0.219      (e)          (e)          P=0.534      |
|POLY 6             |     P=0.623      (e)          P=0.261      (e)         |P=0.245      (e)          (e)          P=0.575      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.171      (e)         |(e)          (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  25/50 (50%)  21/50 (42%)  17/50 (34%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     39.5%        52.5%        54.0%        37.7%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     16/40 (40%)  25/44 (57%)  18/29 (62%)  15/39 (39%) |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     518          729 (T)      519          556         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.432N     P=0.204      P=0.047 *    P=0.531N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.343N     P=0.150      P=0.141      P=0.523N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.326N     P=0.138      P=0.186      P=0.516N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.367N     P=0.158      P=0.102      P=0.537N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.368N     P=0.179      P=0.118      P=0.509N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.288N     P=0.113      P=0.341      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Capsule                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     39/50 (78%)  42/50 (84%)  38/50 (76%)  38/50 (76%) |48/50 (96%)  50/50 (100%) 49/50 (98%)  48/50 (96%)  |
|POLY-3 ADJUSTED (b)|     80.6%        85.7%        83.8%        80.0%       |98.0%        100.0%       98.0%        96.0%        |
|TERMINAL (d)       |     31/40 (78%)  38/44 (86%)  24/29 (83%)  32/39 (82%) |32/32 (100%) 32/32 (100%) 35/36 (97%)  30/32 (94%)  |
|FIRST INCIDENCE    |     380          471          189          233         |264          449          50           77           |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.441      P=0.526N     P=0.066      P=0.562N    |P=0.500      P=0.394      P=0.411N     P=0.474      |
|POLY 3             |     P=0.446N     P=0.344      P=0.453      P=0.579N    |P=0.247N     P=0.506      P=0.763      P=0.506N     |
|POLY 1.5           |     P=0.403N     P=0.336      P=0.487      P=0.545N    |P=0.255N     P=0.490      P=0.753      P=0.515N     |
|POLY 6             |     P=0.502N     P=0.349      P=0.427      P=0.597     |P=0.243N     P=0.514      P=0.764N     P=0.502N     |
|LOGISTIC REGRESSION|     P=0.392N     P=0.385      P=0.482      P=0.509N    |P=0.527N     P=0.425      P=0.456      P=0.645      |
|COCH-ARM / FISHERS |     P=0.331N     P=0.306      P=0.500N     P=0.500N    |P=0.469N     P=0.247      P=0.500      P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          734          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.243      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.052      (e)          (e)          P=0.258      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.050      (e)          (e)          P=0.250      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.056      (e)          (e)          P=0.270      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.222      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |8/50 (16%)   6/50 (12%)   5/50 (10%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.3%        |17.8%        13.5%        11.5%        9.6%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    1/39 (3%)   |6/32 (19%)   6/32 (19%)   5/36 (14%)   3/32 (9%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |683          735 (T)      735 (T)      616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.194      (e)          (e)          P=0.495     |P=0.134N     P=0.394N     P=0.220N     P=0.195N     |
|POLY 3             |     P=0.215      (e)          (e)          P=0.549     |P=0.173N     P=0.408N     P=0.312N     P=0.226N     |
|POLY 1.5           |     P=0.209      (e)          (e)          P=0.532     |P=0.166N     P=0.391N     P=0.301N     P=0.212N     |
|POLY 6             |     P=0.221      (e)          (e)          P=0.566     |P=0.179N     P=0.434N     P=0.328N     P=0.239N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.495     |P=0.176N     P=0.421N     P=0.300N     P=0.215N     |
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.139N     P=0.387N     P=0.277N     P=0.178N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.6%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    2/36 (6%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.599      (e)          P=0.264      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.594      (e)          P=0.262      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.591      (e)          P=0.253      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.603      (e)          P=0.274      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.264      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Depletion Cellular                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          449          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.423N     P=0.244      (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.456N     P=0.266      (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.439N     P=0.258      (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.476N     P=0.278      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.361N     P=0.165      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow: Myeloid Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    1/44 (2%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          700          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.429N     P=0.260      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.430N     P=0.273      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.421N     P=0.260      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.442N     P=0.285      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.417N     P=0.246      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain: Thalamus                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  25/50 (50%)  23/50 (46%)  26/50 (52%) |22/50 (44%)  27/49 (55%)  22/50 (44%)  22/50 (44%)  |
|POLY-3 ADJUSTED (b)|     64.2%        51.0%        56.0%        54.9%       |48.0%        60.1%        48.6%        50.0%        |
|TERMINAL (d)       |     25/40 (63%)  21/44 (48%)  16/29 (55%)  20/39 (51%) |19/32 (59%)  20/31 (65%)  17/36 (47%)  15/32 (47%)  |
|FIRST INCIDENCE    |     380          471          377          246         |465          594          393          523          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.465N     P=0.118N     P=0.525      P=0.331N    |P=0.408N     P=0.169      P=0.431N     P=0.548      |
|POLY 3             |     P=0.312N     P=0.137N     P=0.294N     P=0.242N    |P=0.470N     P=0.173      P=0.570      P=0.518      |
|POLY 1.5           |     P=0.305N     P=0.160N     P=0.238N     P=0.252N    |P=0.467N     P=0.189      P=0.568      P=0.522      |
|POLY 6             |     P=0.323N     P=0.118N     P=0.367N     P=0.235N    |P=0.454N     P=0.160      P=0.576      P=0.532      |
|LOGISTIC REGRESSION|     P=0.321N     P=0.174N     P=0.250N     P=0.276N    |P=0.501N     P=0.164      P=0.545      P=0.488      |
|COCH-ARM / FISHERS |     P=0.283N     P=0.211N     P=0.115N     P=0.273N    |P=0.383N     P=0.183      P=0.580N     P=0.580N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    1/49 (2%)    3/48 (6%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.5%         2.3%         7.0%         2.4%         |
|TERMINAL (d)       |                                                        |2/32 (6%)    1/32 (3%)    3/36 (8%)    1/32 (3%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.468N     P=0.500N     P=0.554      P=0.500N     |
|POLY 3             |                                                        |P=0.525N     P=0.537N     P=0.502      P=0.561N     |
|POLY 1.5           |                                                        |P=0.513N     P=0.522N     P=0.496      P=0.543N     |
|POLY 6             |                                                        |P=0.537N     P=0.558N     P=0.510      P=0.583N     |
|LOGISTIC REGRESSION|                                                        |P=0.468N     P=0.500N     P=0.554      P=0.500N     |
|COCH-ARM / FISHERS |                                                        |P=0.482N     P=0.508N     P=0.480      P=0.508N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    3/50 (6%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     2.2%         6.3%         0.0%         6.8%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    2/44 (5%)    0/29 (0%)    3/39 (8%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     729 (T)      700          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.294      P=0.341      P=0.564N     P=0.296     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.317      P=0.346      P=0.627N     P=0.325     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.319      P=0.332      P=0.586N     P=0.318     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.313      P=0.360      P=0.672N     P=0.331     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.296      P=0.330      (e)          P=0.296     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.324      P=0.309      P=0.500N     P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Spermatocele                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    2/44 (5%)    0/29 (0%)    0/39 (0%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          729 (T)      608          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.481N     P=0.260      P=0.465      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.483N     P=0.273      P=0.559      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.476N     P=0.260      P=0.537      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.494N     P=0.285      P=0.583      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.464N     P=0.260      P=0.530      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    2/50 (4%)    2/50 (4%)   |5/50 (10%)   2/50 (4%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     13.5%        4.2%         5.3%         4.5%        |11.1%        4.5%         0.0%         4.8%         |
|TERMINAL (d)       |     6/40 (15%)   2/44 (5%)    1/29 (3%)    2/39 (5%)   |1/32 (3%)    1/32 (3%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      700          729 (T)     |670          575          ---          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.145N     P=0.106N     P=0.259N     P=0.141N    |P=0.151N     P=0.235N     P=0.036N*    P=0.249N     |
|POLY 3             |     P=0.135N     P=0.119N     P=0.221N     P=0.145N    |P=0.154N     P=0.231N     P=0.039N*    P=0.267N     |
|POLY 1.5           |     P=0.128N     P=0.124N     P=0.192N     P=0.141N    |P=0.150N     P=0.221N     P=0.036N*    P=0.252N     |
|POLY 6             |     P=0.143N     P=0.116N     P=0.255N     P=0.151N    |P=0.158N     P=0.246N     P=0.043N*    P=0.283N     |
|LOGISTIC REGRESSION|     P=0.142N     P=0.106N     P=0.236N     P=0.141N    |P=0.139N     P=0.217N     P=0.035N*    P=0.231N     |
|COCH-ARM / FISHERS |     P=0.114N     P=0.134N     P=0.134N     P=0.134N    |P=0.137N     P=0.218N     P=0.028N*    P=0.218N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.3%         4.5%         2.4%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          735 (T)      393          629          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.351      P=0.500      P=0.240      P=0.481      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.360      P=0.548      P=0.264      P=0.551      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.359      P=0.532      P=0.255      P=0.533      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.365      P=0.571      P=0.278      P=0.574      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.420      P=0.500      P=0.261      P=0.514      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366      P=0.500      P=0.247      P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         0.0%         0.0%        |2.2%         2.2%         4.6%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     464          ---          ---          ---         |726          662          633          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129N     P=0.230N     P=0.292N     P=0.250N    |P=0.389N     P=0.748      P=0.511      P=0.517N     |
|POLY 3             |     P=0.135N     P=0.244N     P=0.341N     P=0.270N    |P=0.422N     P=0.786      P=0.523      P=0.580N     |
|POLY 1.5           |     P=0.127N     P=0.241N     P=0.305N     P=0.258N    |P=0.407N     P=0.774N     P=0.515      P=0.556N     |
|POLY 6             |     P=0.143N     P=0.247N     P=0.382N     P=0.283N    |P=0.438N     P=0.796      P=0.535      P=0.611N     |
|LOGISTIC REGRESSION|     P=0.095N     P=0.302N     P=0.182N     P=0.226N    |P=0.369N     P=0.762      P=0.497      P=0.519N     |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.366N     P=0.753N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Jejunum: Peyer's Patch                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/44 (0%)    0/47 (0%)   |2/46 (4%)    1/45 (2%)    1/47 (2%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.8%         2.5%         2.4%         2.6%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |2/32 (6%)    1/32 (3%)    1/36 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.403N     P=0.500N     P=0.459N     P=0.500N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.450N     P=0.539N     P=0.526N     P=0.569N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.440N     P=0.525N     P=0.514N     P=0.550N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.460N     P=0.557N     P=0.540N     P=0.588N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.403N     P=0.500N     P=0.459N     P=0.500N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.406N     P=0.508N     P=0.492N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  47/50 (94%)  45/50 (90%)  47/50 (94%) |28/50 (56%)  30/50 (60%)  30/50 (60%)  31/50 (62%)  |
|POLY-3 ADJUSTED (b)|     96.1%        94.0%        93.8%        94.0%       |58.6%        60.7%        64.8%        70.3%        |
|TERMINAL (d)       |     39/40 (98%)  41/44 (93%)  27/29 (93%)  36/39 (92%) |20/32 (63%)  18/32 (56%)  24/36 (67%)  24/32 (75%)  |
|FIRST INCIDENCE    |     220          335          92           233         |264          449          50           150          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311      P=0.164N     P=0.057      P=0.578N    |P=0.309      P=0.423      P=0.558N     P=0.313      |
|POLY 3             |     P=0.428N     P=0.490N     P=0.483N     P=0.490N    |P=0.126      P=0.499      P=0.344      P=0.169      |
|POLY 1.5           |     P=0.429N     P=0.495N     P=0.457N     P=0.495N    |P=0.175      P=0.484      P=0.372      P=0.217      |
|POLY 6             |     P=0.421N     P=0.480N     P=0.486N     P=0.480N    |P=0.087      P=0.517      P=0.318      P=0.127      |
|LOGISTIC REGRESSION|     P=0.429N     P=0.541N     P=0.343N     P=0.488N    |P=0.279      P=0.409      P=0.407      P=0.274      |
|COCH-ARM / FISHERS |     P=0.404N     P=0.500N     P=0.218N     P=0.500N    |P=0.322      P=0.420      P=0.420      P=0.342      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  13/50 (26%)  10/50 (20%)  15/50 (30%) |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     24.0%        27.3%        26.1%        33.7%       |2.2%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     9/40 (23%)   13/44 (30%)  8/29 (28%)   14/39 (36%) |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     501          729 (T)      519          652         |733          ---          697          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170      P=0.509      P=0.399      P=0.228     |P=0.414N     P=0.506N     P=0.757N     P=0.500N     |
|POLY 3             |     P=0.187      P=0.458      P=0.536      P=0.225     |P=0.456N     P=0.550N     P=0.784      P=0.580N     |
|POLY 1.5           |     P=0.204      P=0.443      P=0.580      P=0.233     |P=0.442N     P=0.529N     P=0.776      P=0.556N     |
|POLY 6             |     P=0.168      P=0.469      P=0.489      P=0.214     |P=0.471N     P=0.581N     P=0.795      P=0.611N     |
|LOGISTIC REGRESSION|     P=0.199      P=0.452      P=0.565      P=0.239     |P=0.419N     P=0.511N     P=0.757      P=0.518N     |
|COCH-ARM / FISHERS |     P=0.244      P=0.408      P=0.500N     P=0.247     |P=0.405N     P=0.500N     P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.5%         2.1%         7.7%         2.2%        |2.2%         0.0%         6.8%         2.4%         |
|TERMINAL (d)       |     2/40 (5%)    1/44 (2%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      408          617         |732          ---          540          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.499N     P=0.467N     P=0.403      P=0.503N    |P=0.446      P=0.506N     P=0.296      P=0.757      |
|POLY 3             |     P=0.500N     P=0.497N     P=0.477      P=0.527N    |P=0.455      P=0.550N     P=0.325      P=0.780      |
|POLY 1.5           |     P=0.492N     P=0.498N     P=0.480      P=0.519N    |P=0.455      P=0.529N     P=0.318      P=0.773      |
|POLY 6             |     P=0.509N     P=0.498N     P=0.474      P=0.538N    |P=0.459      P=0.581N     P=0.337      P=0.791      |
|LOGISTIC REGRESSION|     P=0.454N     P=0.467N     P=0.549      P=0.500N    |P=0.478      P=0.510N     P=0.312      P=0.744      |
|COCH-ARM / FISHERS |     P=0.474N     P=0.500N     P=0.500      P=0.500N    |P=0.469      P=0.500N     P=0.309      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         2.3%         2.4%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    0/32 (0%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |698          ---          697          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.514N     P=0.243N     P=0.502N     P=0.513N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.539N     P=0.267N     P=0.541N     P=0.565N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.530N     P=0.253N     P=0.529N     P=0.546N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.549N     P=0.288N     P=0.558N     P=0.587N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.522N     P=0.238N     P=0.507N     P=0.530N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.500N     P=0.247N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    5/50 (10%)   2/50 (4%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         12.3%        4.4%        |2.2%         2.2%         0.0%         2.4%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          377          556         |735 (T)      691          ---          681          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.107      (e)          P=0.026 *    P=0.242     |P=0.634N     P=0.757N     P=0.477N     P=0.749      |
|POLY 3             |     P=0.107      (e)          P=0.028 *    P=0.266     |P=0.651N     P=0.786      P=0.561N     P=0.781      |
|POLY 1.5           |     P=0.106      (e)          P=0.028 *    P=0.256     |P=0.641N     P=0.775N     P=0.541N     P=0.773      |
|POLY 6             |     P=0.108      (e)          P=0.028 *    P=0.276     |P=0.663N     P=0.797      P=0.587N     P=0.792      |
|LOGISTIC REGRESSION|     P=0.122      (e)          P=0.070      P=0.243     |P=0.627N     P=0.763N     (e)          P=0.752      |
|COCH-ARM / FISHERS |     P=0.108      (e)          P=0.028 *    P=0.247     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Acute                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    6/50 (12%)   1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         14.6%        2.2%        |0.0%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     578          700          377          657         |---          575          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.453      P=0.740N     P=0.045 *    P=0.758     |P=0.582N     P=0.500      (e)          (e)          |
|POLY 3             |     P=0.468      P=0.765N     P=0.048 *    P=0.783     |P=0.626N     P=0.548      (e)          (e)          |
|POLY 1.5           |     P=0.471      P=0.763N     P=0.049 *    P=0.775     |P=0.607N     P=0.532      (e)          (e)          |
|POLY 6             |     P=0.462      P=0.768N     P=0.046 *    P=0.789     |P=0.648N     P=0.570      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.538      P=0.729      P=0.123      P=0.758N    |P=0.534N     P=0.441      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.477      P=0.753N     P=0.056      P=0.753N    |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  45/50 (90%)  38/50 (76%)  46/50 (92%) |16/50 (32%)  6/50 (12%)   9/50 (18%)   11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     86.7%        90.8%        91.1%        96.2%       |35.8%        13.5%        20.6%        25.7%        |
|TERMINAL (d)       |     36/40 (90%)  41/44 (93%)  29/29 (100%) 38/39 (97%) |13/32 (41%)  6/32 (19%)   8/36 (22%)   8/32 (25%)   |
|FIRST INCIDENCE    |     220          335          458          443         |721          735 (T)      655          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.070      P=0.511N     P=0.062      P=0.182     |P=0.296N     P=0.015N*    P=0.048N*    P=0.200N     |
|POLY 3             |     P=0.056      P=0.371      P=0.373      P=0.083     |P=0.335N     P=0.013N*    P=0.092N     P=0.224N     |
|POLY 1.5           |     P=0.078      P=0.329      P=0.541      P=0.085     |P=0.335N     P=0.012N*    P=0.090N     P=0.217N     |
|POLY 6             |     P=0.049 *    P=0.422      P=0.220      P=0.100     |P=0.328N     P=0.015N*    P=0.095N     P=0.228N     |
|LOGISTIC REGRESSION|     P=0.135      P=0.305      P=0.607      P=0.156     |P=0.380N     P=0.017N*    P=0.094N     P=0.244N     |
|COCH-ARM / FISHERS |     P=0.259      P=0.277      P=0.227N     P=0.178     |P=0.299N     P=0.014N*    P=0.083N     P=0.184N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.7%         6.5%         2.3%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |1/32 (3%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |670          449          697          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.063N     P=0.648      P=0.313N     P=0.138N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.067N     P=0.668N     P=0.341N     P=0.155N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.062N     P=0.660N     P=0.330N     P=0.144N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.072N     P=0.679N     P=0.356N     P=0.170N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.044N*    P=0.621      P=0.311N     P=0.131N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.052N     P=0.661N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.0%         0.0%         0.0%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/40 (10%)   0/44 (0%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.147N     P=0.052N     P=0.111N     P=0.187N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.147N     P=0.057N     P=0.107N     P=0.196N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.139N     P=0.058N     P=0.090N     P=0.190N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.157N     P=0.057N     P=0.128N     P=0.205N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.147N     (e)          (e)          P=0.187N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.125N     P=0.059N     P=0.059N     P=0.181N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    11/50 (22%)  6/50 (12%)   3/50 (6%)   |2/50 (4%)    3/50 (6%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.5%         23.1%        16.0%        6.8%        |4.5%         6.8%         4.6%         4.8%         |
|TERMINAL (d)       |     2/40 (5%)    11/44 (25%)  6/29 (21%)   3/39 (8%)   |2/32 (6%)    3/32 (9%)    2/36 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.419N     P=0.013 *    P=0.053      P=0.488     |P=0.517N     P=0.500      P=0.652N     P=0.696      |
|POLY 3             |     P=0.375N     P=0.011 *    P=0.098      P=0.520     |P=0.574N     P=0.520      P=0.708      P=0.697      |
|POLY 1.5           |     P=0.367N     P=0.009 **   P=0.106      P=0.513     |P=0.561N     P=0.518      P=0.702      P=0.694      |
|POLY 6             |     P=0.389N     P=0.012 *    P=0.089      P=0.525     |P=0.587N     P=0.524      P=0.716      P=0.704      |
|LOGISTIC REGRESSION|     P=0.419N     P=0.013 *    P=0.053      P=0.488     |P=0.517N     P=0.500      P=0.652N     P=0.696      |
|COCH-ARM / FISHERS |     P=0.351N     P=0.007 **   P=0.134      P=0.500     |P=0.523N     P=0.500      P=0.691N     P=0.691N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     27/50 (54%)  34/50 (68%)  33/50 (66%)  29/50 (58%) |29/50 (58%)  24/50 (48%)  29/50 (58%)  31/50 (62%)  |
|POLY-3 ADJUSTED (b)|     60.5%        70.0%        78.4%        62.9%       |64.5%        53.2%        65.3%        70.6%        |
|TERMINAL (d)       |     26/40 (65%)  31/44 (71%)  24/29 (83%)  25/39 (64%) |26/32 (81%)  21/32 (66%)  25/36 (69%)  22/32 (69%)  |
|FIRST INCIDENCE    |     714          471          377          443         |673          582          645          569          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.290      P=0.254      P=0.002 **   P=0.365     |P=0.226      P=0.189N     P=0.344N     P=0.383      |
|POLY 3             |     P=0.523      P=0.228      P=0.053      P=0.502     |P=0.172      P=0.189N     P=0.571      P=0.358      |
|POLY 1.5           |     P=0.506      P=0.178      P=0.062      P=0.466     |P=0.167      P=0.181N     P=0.564      P=0.349      |
|POLY 6             |     P=0.535      P=0.283      P=0.049 *    P=0.534     |P=0.206      P=0.205N     P=0.590      P=0.403      |
|LOGISTIC REGRESSION|     P=0.407      P=0.220      P=0.018 *    P=0.403     |P=0.084      P=0.255N     P=0.453      P=0.213      |
|COCH-ARM / FISHERS |     P=0.510      P=0.109      P=0.154      P=0.420     |P=0.242      P=0.212N     P=0.580N     P=0.419      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         4.5%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          703          622          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.643N     P=0.500      P=0.237      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.676N     P=0.548      P=0.263      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.660N     P=0.532      P=0.254      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.682      P=0.571      P=0.277      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.600N     P=0.501      P=0.246      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.500      P=0.247      (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         2.1%         0.0%         2.3%        |2.2%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    1/44 (2%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     464          729 (T)      ---          729 (T)     |670          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.392N     P=0.476N     P=0.291N     P=0.508N    |P=0.247N     P=0.750      P=0.529N     P=0.535N     |
|POLY 3             |     P=0.404N     P=0.501N     P=0.340N     P=0.535N    |P=0.273N     P=0.784      P=0.561N     P=0.580N     |
|POLY 1.5           |     P=0.392N     P=0.500N     P=0.305N     P=0.523N    |P=0.262N     P=0.775N     P=0.541N     P=0.555N     |
|POLY 6             |     P=0.418N     P=0.502N     P=0.382N     P=0.550N    |P=0.287N     P=0.793      P=0.587N     P=0.611N     |
|LOGISTIC REGRESSION|     P=0.361N     P=0.561N     P=0.189N     P=0.495N    |P=0.241N     P=0.762N     P=0.498N     P=0.498N     |
|COCH-ARM / FISHERS |     P=0.366N     P=0.500N     P=0.247N     P=0.500N    |P=0.236N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   1/50 (2%)    3/50 (6%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.5%         10.3%        2.7%         6.7%        |0.0%         4.5%         0.0%         2.4%         |
|TERMINAL (d)       |     2/40 (5%)    4/44 (9%)    1/29 (3%)    2/39 (5%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      471          729 (T)      556         |---          575          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.562      P=0.255      P=0.612N     P=0.495     |P=0.534      P=0.240      (e)          P=0.500      |
|POLY 3             |     P=0.589N     P=0.261      P=0.615N     P=0.524     |P=0.546      P=0.265      (e)          P=0.551      |
|POLY 1.5           |     P=0.581N     P=0.246      P=0.579N     P=0.515     |P=0.543      P=0.257      (e)          P=0.534      |
|POLY 6             |     P=0.592      P=0.275      P=0.653N     P=0.531     |P=0.552      P=0.277      (e)          P=0.575      |
|LOGISTIC REGRESSION|     P=0.570N     P=0.204      P=0.612N     P=0.499     |P=0.540      P=0.219      (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.562N     P=0.218      P=0.500N     P=0.500     |P=0.539      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     13.0%        6.2%         2.6%         6.7%        |2.2%         6.7%         2.3%         0.0%         |
|TERMINAL (d)       |     3/40 (8%)    1/44 (2%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     464          335          377          652         |670          575          633          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.220N     P=0.219N     P=0.111N     P=0.264N    |P=0.224N     P=0.302      P=0.742      P=0.535N     |
|POLY 3             |     P=0.214N     P=0.223N     P=0.107N     P=0.269N    |P=0.241N     P=0.327      P=0.783      P=0.580N     |
|POLY 1.5           |     P=0.202N     P=0.228N     P=0.088N     P=0.260N    |P=0.228N     P=0.323      P=0.775      P=0.555N     |
|POLY 6             |     P=0.226N     P=0.220N     P=0.131N     P=0.280N    |P=0.255N     P=0.333      P=0.793      P=0.611N     |
|LOGISTIC REGRESSION|     P=0.151N     P=0.347N     P=0.032N*    P=0.238N    |P=0.188N     P=0.288      P=0.758N     P=0.498N     |
|COCH-ARM / FISHERS |     P=0.178N     P=0.243N     P=0.056N     P=0.243N    |P=0.200N     P=0.309      P=0.753N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          189          246         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.071      (e)          P=0.488      P=0.240     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.073      (e)          P=0.557      P=0.267     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.072      (e)          P=0.536      P=0.257     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.074      (e)          P=0.582      P=0.277     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.062      (e)          P=0.874      P=0.251     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |4/50 (8%)    3/50 (6%)    6/50 (12%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         2.7%         4.5%        |8.9%         6.7%         13.9%        7.2%         |
|TERMINAL (d)       |     0/40 (0%)    1/44 (2%)    1/29 (3%)    2/39 (5%)   |3/32 (9%)    2/32 (6%)    6/36 (17%)   2/32 (6%)    |
|FIRST INCIDENCE    |     ---          665          729 (T)      729 (T)     |673          594          735 (T)      664          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.225      P=0.263      P=0.436      P=0.233     |P=0.506N     P=0.506N     P=0.429      P=0.523N     |
|POLY 3             |     P=0.247      P=0.273      P=0.560      P=0.264     |P=0.567N     P=0.518N     P=0.364      P=0.565N     |
|POLY 1.5           |     P=0.247      P=0.261      P=0.537      P=0.254     |P=0.552N     P=0.505N     P=0.366      P=0.547N     |
|POLY 6             |     P=0.247      P=0.286      P=0.586      P=0.273     |P=0.580N     P=0.537N     P=0.363      P=0.583N     |
|LOGISTIC REGRESSION|     P=0.233      P=0.233      P=0.436      P=0.233     |P=0.547N     P=0.498N     P=0.342      P=0.538N     |
|COCH-ARM / FISHERS |     P=0.245      P=0.247      P=0.500      P=0.247     |P=0.500N     P=0.500N     P=0.370      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/50 (8%)    5/50 (10%)  |4/50 (8%)    2/50 (4%)    2/50 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     4.5%         4.2%         10.6%        11.1%       |8.7%         4.5%         4.6%         9.4%         |
|TERMINAL (d)       |     2/40 (5%)    2/44 (5%)    2/29 (7%)    4/39 (10%)  |1/32 (3%)    0/32 (0%)    2/36 (6%)    2/32 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      637          543         |465          594          735 (T)      150          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.098      P=0.660N     P=0.212      P=0.212     |P=0.478      P=0.356N     P=0.328N     P=0.610      |
|POLY 3             |     P=0.107      P=0.686N     P=0.297      P=0.232     |P=0.481      P=0.364N     P=0.385N     P=0.619      |
|POLY 1.5           |     P=0.108      P=0.688N     P=0.306      P=0.226     |P=0.485      P=0.349N     P=0.369N     P=0.628      |
|POLY 6             |     P=0.105      P=0.684N     P=0.289      P=0.237     |P=0.478      P=0.385N     P=0.406N     P=0.613      |
|LOGISTIC REGRESSION|     P=0.104      P=0.660N     P=0.251      P=0.215     |P=0.567      P=0.392N     P=0.326N     P=0.578N     |
|COCH-ARM / FISHERS |     P=0.113      P=0.691N     P=0.339      P=0.218     |P=0.500      P=0.339N     P=0.339N     P=0.643N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.5%        |2.2%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    2/39 (5%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |677          ---          ---          150          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.045 *    (e)          (e)          P=0.233     |P=0.581      P=0.510N     P=0.520N     P=0.746      |
|POLY 3             |     P=0.047 *    (e)          (e)          P=0.264     |P=0.620      P=0.550N     P=0.561N     P=0.781      |
|POLY 1.5           |     P=0.046 *    (e)          (e)          P=0.254     |P=0.609      P=0.529N     P=0.541N     P=0.774      |
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.273     |P=0.633      P=0.581N     P=0.587N     P=0.790      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.233     |P=0.670N     P=0.505N     P=0.499N     P=0.699N     |
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.595      P=0.500N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   2/50 (4%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     11.1%        10.5%        5.3%         6.8%        |0.0%         2.3%         0.0%         2.4%         |
|TERMINAL (d)       |     4/40 (10%)   5/44 (11%)   1/29 (3%)    3/39 (8%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |     547          729 (T)      714          729 (T)     |---          735 (T)      ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.268N     P=0.571N     P=0.353N     P=0.368N    |P=0.407      P=0.500      (e)          P=0.500      |
|POLY 3             |     P=0.256N     P=0.606N     P=0.331N     P=0.384N    |P=0.424      P=0.548      (e)          P=0.551      |
|POLY 1.5           |     P=0.244N     P=0.613N     P=0.293N     P=0.374N    |P=0.417      P=0.532      (e)          P=0.534      |
|POLY 6             |     P=0.271N     P=0.602N     P=0.375N     P=0.398N    |P=0.434      P=0.571      (e)          P=0.575      |
|LOGISTIC REGRESSION|     P=0.247N     P=0.610N     P=0.276N     P=0.359N    |(e)          P=0.500      (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.220N     P=0.630N     P=0.218N     P=0.357N    |P=0.405      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    2/49 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.5%         2.1%         2.7%         0.0%        |2.2%         2.3%         4.7%         4.7%         |
|TERMINAL (d)       |     2/40 (5%)    1/44 (2%)    1/29 (3%)    0/39 (0%)   |1/32 (3%)    1/31 (3%)    1/35 (3%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |735 (T)      735 (T)      540          150          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.175N     P=0.467N     P=0.612N     P=0.244N    |P=0.338      P=0.755      P=0.521      P=0.500      |
|POLY 3             |     P=0.174N     P=0.497N     P=0.615N     P=0.267N    |P=0.337      P=0.782      P=0.517      P=0.517      |
|POLY 1.5           |     P=0.167N     P=0.498N     P=0.579N     P=0.257N    |P=0.336      P=0.774      P=0.508      P=0.511      |
|POLY 6             |     P=0.182N     P=0.498N     P=0.653N     P=0.280N    |P=0.341      P=0.792      P=0.529      P=0.528      |
|LOGISTIC REGRESSION|     P=0.175N     P=0.467N     P=0.612N     (e)         |P=0.396      P=0.755      P=0.497      P=0.565      |
|COCH-ARM / FISHERS |     P=0.153N     P=0.500N     P=0.500N     P=0.247N    |P=0.339      P=0.747      P=0.492      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   8/50 (16%)   3/50 (6%)    5/50 (10%)  |1/49 (2%)    2/48 (4%)    3/47 (6%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     16.0%        16.8%        7.9%         11.2%       |2.3%         4.6%         7.2%         2.4%         |
|TERMINAL (d)       |     7/40 (18%)   7/44 (16%)   1/29 (3%)    4/39 (10%)  |0/31 (0%)    2/32 (6%)    3/35 (9%)    1/32 (3%)    |
|FIRST INCIDENCE    |     729 (T)      700          637          657         |732          735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.278N     P=0.579      P=0.313N     P=0.397N    |P=0.567N     P=0.504      P=0.345      P=0.760N     |
|POLY 3             |     P=0.238N     P=0.579      P=0.247N     P=0.383N    |P=0.608      P=0.524      P=0.310      P=0.782      |
|POLY 1.5           |     P=0.228N     P=0.559      P=0.215N     P=0.377N    |P=0.610      P=0.516      P=0.304      P=0.774      |
|POLY 6             |     P=0.251N     P=0.596      P=0.283N     P=0.392N    |P=0.610      P=0.535      P=0.318      P=0.793      |
|LOGISTIC REGRESSION|     P=0.247N     P=0.583      P=0.247N     P=0.381N    |P=0.588N     P=0.489      P=0.301      P=0.751      |
|COCH-ARM / FISHERS |     P=0.207N     P=0.517      P=0.151N     P=0.365N    |P=0.576N     P=0.492      P=0.293      P=0.753N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/4 (0%)     0/5 (0%)     0/2 (0%)     0/3 (0%)    |0/8 (0%)     0/12 (0%)    2/15 (13%)   0/9 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         15.0%        0.0%         |
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     0/2 (0%)     0/3 (0%)    |0/1 (0%)     0/4 (0%)     2/11 (18%)   0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.703N     (e)          P=0.814      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.617      (e)          P=0.412      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.609      (e)          P=0.396      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.638      (e)          P=0.447      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.814      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.617      (e)          P=0.415      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/4 (0%)     0/5 (0%)     0/2 (0%)     0/3 (0%)    |2/8 (25%)    2/12 (17%)   2/15 (13%)   0/9 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |27.5%        21.7%        15.0%        0.0%         |
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     0/2 (0%)     0/3 (0%)    |1/1 (100%)   1/4 (25%)    2/11 (18%)   0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |721          704          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.048N*    P=0.470N     P=0.131N     P=0.114N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.153N     P=0.658N     P=0.484N     P=0.290N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.142N     P=0.613N     P=0.470N     P=0.254N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.168N     P=0.708N     P=0.499N     P=0.342N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.107N     P=0.653N     P=0.339N     P=0.224N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.535N     P=0.435N     P=0.206N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Iliac                                                                                                                |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/4 (75%)    1/5 (20%)    0/2 (0%)     0/3 (0%)    |0/8 (0%)     0/12 (0%)    0/15 (0%)    0/9 (0%)     |
|POLY-3 ADJUSTED (b)|     75.0%        20.0%        0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/3 (67%)    1/5 (20%)    0/2 (0%)     0/3 (0%)    |0/1 (0%)     0/4 (0%)     0/11 (0%)    0/4 (0%)     |
|FIRST INCIDENCE    |     380          729 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.049N*    P=0.152N     P=0.179N     P=0.110N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.031N*    P=0.152N     P=0.159N     P=0.061N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.031N*    P=0.152N     P=0.159N     P=0.061N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.031N*    P=0.152N     P=0.159N     P=0.061N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.152N     (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.052N     P=0.167N     P=0.200N     P=0.114N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/4 (0%)     0/5 (0%)     1/2 (50%)    0/3 (0%)    |0/8 (0%)     0/12 (0%)    4/15 (27%)   0/9 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         50.0%        0.0%        |0.0%         0.0%         29.1%        0.0%         |
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     1/2 (50%)    0/3 (0%)    |0/1 (0%)     0/4 (0%)     3/11 (27%)   0/4 (0%)     |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          622          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.665      (e)          P=0.419      (e)         |P=0.667N     (e)          P=0.353      (e)          |
|POLY 3             |     P=0.727      (e)          P=0.445      (e)         |P=0.472      (e)          P=0.163      (e)          |
|POLY 1.5           |     P=0.708      (e)          P=0.410      (e)         |P=0.476      (e)          P=0.154      (e)          |
|POLY 6             |     P=0.736      (e)          P=0.465      (e)         |P=0.479      (e)          P=0.186      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.419      (e)         |P=0.487      (e)          P=0.150      (e)          |
|COCH-ARM / FISHERS |     P=0.640      (e)          P=0.333      (e)         |P=0.514      (e)          P=0.154      (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/4 (100%)   2/2 (100%)   6/6 (100%)   8/8 (100%)  |19/20 (95%)  17/19 (89%)  14/16 (88%)  11/12 (92%)  |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       100.0%       100.0%      |95.9%        93.3%        91.5%        91.7%        |
|TERMINAL (d)       |     3/3 (100%)   1/1 (100%)   6/6 (100%)   5/5 (100%)  |15/15 (100%) 14/14 (100%) 13/13 (100%) 8/9 (89%)    |
|FIRST INCIDENCE    |     380          700          729 (T)      568         |593          662          633          569          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.263N     P=0.524N     P=0.201N     P=0.361N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.438N     P=0.665N     P=0.587N     P=0.615N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.462N     P=0.575N     P=0.500N     P=0.629N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.386N     P=0.819N     P=0.765N     P=0.587N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.612      P=0.582N     P=0.498N     P=0.657N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.483N     P=0.480N     P=0.415N     P=0.617N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     9.0%         0.0%         0.0%         2.3%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     4/40 (10%)   0/44 (0%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.147N     P=0.052N     P=0.111N     P=0.187N    |P=0.190      (e)          (e)          P=0.486      |
|POLY 3             |     P=0.147N     P=0.057N     P=0.107N     P=0.196N    |P=0.229      (e)          (e)          P=0.551      |
|POLY 1.5           |     P=0.139N     P=0.058N     P=0.090N     P=0.190N    |P=0.218      (e)          (e)          P=0.533      |
|POLY 6             |     P=0.157N     P=0.057N     P=0.128N     P=0.205N    |P=0.243      (e)          (e)          P=0.574      |
|LOGISTIC REGRESSION|     P=0.147N     (e)          (e)          P=0.187N    |P=0.214      (e)          (e)          P=0.517      |
|COCH-ARM / FISHERS |     P=0.125N     P=0.059N     P=0.059N     P=0.181N    |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    2/49 (4%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         4.6%         0.0%         4.8%         |
|TERMINAL (d)       |                                                        |0/32 (0%)    2/32 (6%)    0/36 (0%)    1/32 (3%)    |
|FIRST INCIDENCE    |                                                        |---          735 (T)      ---          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.243      P=0.238      (e)          P=0.231      |
|POLY 3             |                                                        |P=0.252      P=0.260      (e)          P=0.258      |
|POLY 1.5           |                                                        |P=0.250      P=0.252      (e)          P=0.250      |
|POLY 6             |                                                        |P=0.256      P=0.272      (e)          P=0.270      |
|LOGISTIC REGRESSION|                                                        |P=0.225      P=0.238      (e)          P=0.221      |
|COCH-ARM / FISHERS |                                                        |P=0.249      P=0.242      (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |11/50 (22%)  9/49 (18%)   9/50 (18%)   11/50 (22%)  |
|POLY-3 ADJUSTED (b)|                                                        |24.4%        20.3%        20.6%        26.2%        |
|TERMINAL (d)       |                                                        |9/32 (28%)   6/32 (19%)   8/36 (22%)   9/32 (28%)   |
|FIRST INCIDENCE    |                                                        |673          691          633          523          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.492      P=0.411N     P=0.318N     P=0.580      |
|POLY 3             |                                                        |P=0.441      P=0.427N     P=0.443N     P=0.539      |
|POLY 1.5           |                                                        |P=0.454      P=0.414N     P=0.431N     P=0.553      |
|POLY 6             |                                                        |P=0.429      P=0.444N     P=0.460N     P=0.525      |
|LOGISTIC REGRESSION|                                                        |P=0.414      P=0.427N     P=0.437N     P=0.513      |
|COCH-ARM / FISHERS |                                                        |P=0.507      P=0.421N     P=0.402N     P=0.595N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    1/49 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.2%         2.3%         4.6%         0.0%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    1/32 (3%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      735 (T)      633          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.370N     P=0.762      P=0.525      P=0.500N     |
|POLY 3             |                                                        |P=0.420N     P=0.783      P=0.524      P=0.580N     |
|POLY 1.5           |                                                        |P=0.405N     P=0.775      P=0.515      P=0.556N     |
|POLY 6             |                                                        |P=0.436N     P=0.793      P=0.536      P=0.611N     |
|LOGISTIC REGRESSION|                                                        |P=0.380N     P=0.762      P=0.496      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.365N     P=0.747      P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     6.7%         2.1%         5.3%         4.4%        |2.2%         2.3%         0.0%         7.2%         |
|TERMINAL (d)       |     3/40 (8%)    0/44 (0%)    1/29 (3%)    1/39 (3%)   |1/32 (3%)    1/32 (3%)    0/36 (0%)    3/32 (9%)    |
|FIRST INCIDENCE    |     729 (T)      700          714          443         |735 (T)      735 (T)      ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.538N     P=0.274N     P=0.643N     P=0.509N    |P=0.158      P=0.762      P=0.477N     P=0.304      |
|POLY 3             |     P=0.530N     P=0.296N     P=0.620N     P=0.517N    |P=0.164      P=0.786      P=0.561N     P=0.308      |
|POLY 1.5           |     P=0.520N     P=0.299N     P=0.584N     P=0.511N    |P=0.161      P=0.775N     P=0.541N     P=0.305      |
|POLY 6             |     P=0.542N     P=0.294N     P=0.659N     P=0.526N    |P=0.168      P=0.796      P=0.587N     P=0.314      |
|LOGISTIC REGRESSION|     P=0.505N     P=0.279N     P=0.630N     P=0.498N    |P=0.158      P=0.762      (e)          P=0.304      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.309N     P=0.500N     P=0.500N    |P=0.160      P=0.753N     P=0.500N     P=0.309      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Duct                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         0.0%         0.0%        |0.0%         2.3%         0.0%         4.8%         |
|TERMINAL (d)       |     1/40 (3%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    1/32 (3%)    0/36 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |     380          ---          ---          ---         |---          735 (T)      ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126N     P=0.229N     P=0.285N     P=0.245N    |P=0.138      P=0.500      (e)          P=0.238      |
|POLY 3             |     P=0.135N     P=0.244N     P=0.341N     P=0.270N    |P=0.147      P=0.548      (e)          P=0.258      |
|POLY 1.5           |     P=0.127N     P=0.241N     P=0.306N     P=0.258N    |P=0.144      P=0.532      (e)          P=0.250      |
|POLY 6             |     P=0.143N     P=0.247N     P=0.382N     P=0.283N    |P=0.152      P=0.571      (e)          P=0.270      |
|LOGISTIC REGRESSION|     P=0.089N     P=0.320N     P=0.161N     P=0.221N    |(e)          P=0.500      (e)          P=0.238      |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.140      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    0/47 (0%)   |2/49 (4%)    1/49 (2%)    1/47 (2%)    2/46 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         2.3%         2.4%         5.2%         |
|TERMINAL (d)       |     0/40 (0%)    0/43 (0%)    0/29 (0%)    0/37 (0%)   |2/32 (6%)    0/32 (0%)    1/35 (3%)    1/30 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      663          735 (T)      646          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.525      P=0.505N     P=0.469N     P=0.663      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.527      P=0.527N     P=0.556N     P=0.673      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.524      P=0.513N     P=0.544N     P=0.670      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.533      P=0.546N     P=0.571N     P=0.680      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.509      P=0.499N     P=0.469N     P=0.648      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.531      P=0.500N     P=0.516N     P=0.667      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/49 (6%)    2/49 (4%)    0/47 (0%)   |0/49 (0%)    1/49 (2%)    0/47 (0%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         6.3%         5.4%         0.0%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    2/43 (5%)    1/29 (3%)    0/37 (0%)   |0/32 (0%)    1/32 (3%)    0/35 (0%)    0/30 (0%)    |
|FIRST INCIDENCE    |     501          335          645          ---         |---          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.163N     P=0.523      P=0.593      P=0.248N    |P=0.576N     P=0.500      (e)          (e)          |
|POLY 3             |     P=0.162N     P=0.535      P=0.661      P=0.278N    |P=0.639N     P=0.545      (e)          (e)          |
|POLY 1.5           |     P=0.156N     P=0.521      P=0.666      P=0.267N    |P=0.620N     P=0.530      (e)          (e)          |
|POLY 6             |     P=0.171N     P=0.547      P=0.657      P=0.293N    |P=0.660N     P=0.565      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.132N     P=0.368      P=0.698      P=0.261N    |(e)          P=0.500      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.146N     P=0.490      P=0.684      P=0.263N    |P=0.578N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/49 (0%)    0/47 (0%)   |5/49 (10%)   3/49 (6%)    8/47 (17%)   10/46 (22%)  |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |11.2%        6.8%         19.5%        25.9%        |
|TERMINAL (d)       |     1/40 (3%)    0/43 (0%)    0/29 (0%)    0/37 (0%)   |4/32 (13%)   2/32 (6%)    7/35 (20%)   8/30 (27%)   |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |587          594          697          569          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.327N     P=0.486N     P=0.564N     P=0.516N    |P=0.027 *    P=0.359N     P=0.323      P=0.105      |
|POLY 3             |     P=0.353N     P=0.526N     P=0.633N     P=0.557N    |P=0.017 *    P=0.376N     P=0.235      P=0.078      |
|POLY 1.5           |     P=0.339N     P=0.518N     P=0.592N     P=0.540N    |P=0.018 *    P=0.362N     P=0.238      P=0.083      |
|POLY 6             |     P=0.370N     P=0.535N     P=0.678N     P=0.578N    |P=0.016 *    P=0.394N     P=0.232      P=0.075      |
|LOGISTIC REGRESSION|     P=0.327N     (e)          (e)          (e)         |P=0.017 *    P=0.356N     P=0.228      P=0.078      |
|COCH-ARM / FISHERS |     P=0.312N     P=0.505N     P=0.505N     P=0.515N    |P=0.027 *    P=0.357N     P=0.249      P=0.104      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  33/50 (66%)  26/50 (52%)  30/50 (60%) |                                                    |
|POLY-3 ADJUSTED (b)|     65.7%        67.3%        64.8%        65.0%       |                                                    |
|TERMINAL (d)       |     28/40 (70%)  29/44 (66%)  20/29 (69%)  25/39 (64%) |                                                    |
|FIRST INCIDENCE    |     464          471          458          543         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.437      P=0.576      P=0.233      P=0.526     |                                                    |
|POLY 3             |     P=0.482N     P=0.528      P=0.572N     P=0.565N    |                                                    |
|POLY 1.5           |     P=0.470N     P=0.460      P=0.492N     P=0.579N    |                                                    |
|POLY 6             |     P=0.494N     P=0.593N     P=0.580      P=0.548N    |                                                    |
|LOGISTIC REGRESSION|     P=0.514N     P=0.466      P=0.543      P=0.575     |                                                    |
|COCH-ARM / FISHERS |     P=0.413N     P=0.339      P=0.273N     P=0.581N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   13/50 (26%)  9/50 (18%)   12/50 (24%) |                                                    |
|POLY-3 ADJUSTED (b)|     15.5%        27.0%        22.8%        26.5%       |                                                    |
|TERMINAL (d)       |     6/40 (15%)   11/44 (25%)  5/29 (17%)   9/39 (23%)  |                                                    |
|FIRST INCIDENCE    |     547          645          458          556         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.178      P=0.161      P=0.201      P=0.151     |                                                    |
|POLY 3             |     P=0.206      P=0.140      P=0.300      P=0.159     |                                                    |
|POLY 1.5           |     P=0.212      P=0.127      P=0.322      P=0.156     |                                                    |
|POLY 6             |     P=0.200      P=0.153      P=0.278      P=0.161     |                                                    |
|LOGISTIC REGRESSION|     P=0.211      P=0.122      P=0.340      P=0.151     |                                                    |
|COCH-ARM / FISHERS |     P=0.230      P=0.105      P=0.393      P=0.154     |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |                                                    |
|POLY-3 ADJUSTED (b)|     6.7%         2.1%         0.0%         6.8%        |                                                    |
|TERMINAL (d)       |     3/40 (8%)    1/44 (2%)    0/28 (0%)    2/39 (5%)   |                                                    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          700         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.486      P=0.272N     P=0.191N     P=0.648     |                                                    |
|POLY 3             |     P=0.507      P=0.297N     P=0.196N     P=0.679     |                                                    |
|POLY 1.5           |     P=0.512      P=0.300N     P=0.170N     P=0.673     |                                                    |
|POLY 6             |     P=0.502      P=0.296N     P=0.229N     P=0.684     |                                                    |
|LOGISTIC REGRESSION|     P=0.490      P=0.272N     (e)          P=0.655     |                                                    |
|COCH-ARM / FISHERS |     P=0.525      P=0.309N     P=0.125N     P=0.661N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    9/50 (18%)   8/50 (16%)   2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     6.7%         18.9%        20.8%        4.5%        |                                                    |
|TERMINAL (d)       |     2/40 (5%)    8/44 (18%)   6/29 (21%)   2/39 (5%)   |                                                    |
|FIRST INCIDENCE    |     578          700          519          729 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.305N     P=0.090      P=0.041 *    P=0.509N    |                                                    |
|POLY 3             |     P=0.274N     P=0.077      P=0.064      P=0.530N    |                                                    |
|POLY 1.5           |     P=0.263N     P=0.071      P=0.072      P=0.519N    |                                                    |
|POLY 6             |     P=0.291N     P=0.082      P=0.056      P=0.544N    |                                                    |
|LOGISTIC REGRESSION|     P=0.269N     P=0.071      P=0.070      P=0.501N    |                                                    |
|COCH-ARM / FISHERS |     P=0.246N     P=0.061      P=0.100      P=0.500N    |                                                    |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   8/50 (16%)   5/50 (10%)   6/50 (12%)  |13/49 (27%)  9/50 (18%)   16/50 (32%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     19.2%        16.1%        12.8%        13.5%       |28.7%        19.8%        35.0%        25.2%        |
|TERMINAL (d)       |     6/40 (15%)   4/44 (9%)    2/29 (7%)    5/39 (13%)  |7/32 (22%)   5/32 (16%)   9/36 (25%)   7/32 (22%)   |
|FIRST INCIDENCE    |     220          335          458          652         |465          582          540          150          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.267N     P=0.437N     P=0.358N     P=0.308N    |P=0.536      P=0.262N     P=0.395      P=0.444N     |
|POLY 3             |     P=0.270N     P=0.455N     P=0.332N     P=0.336N    |P=0.537      P=0.237N     P=0.344      P=0.458N     |
|POLY 1.5           |     P=0.250N     P=0.471N     P=0.291N     P=0.322N    |P=0.547N     P=0.221N     P=0.341      P=0.434N     |
|POLY 6             |     P=0.291N     P=0.439N     P=0.373N     P=0.350N    |P=0.525      P=0.257N     P=0.354      P=0.484N     |
|LOGISTIC REGRESSION|     P=0.180N     P=0.515      P=0.135N     P=0.280N    |P=0.490N     P=0.217N     P=0.348      P=0.374N     |
|COCH-ARM / FISHERS |     P=0.204N     P=0.500N     P=0.194N     P=0.288N    |P=0.492N     P=0.218N     P=0.353      P=0.385N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         6.3%         0.0%         0.0%        |0.0%         6.7%         2.3%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    3/44 (7%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    2/32 (6%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          712          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.175N     P=0.340      P=0.564N     P=0.505N    |P=0.368N     P=0.116      P=0.523      (e)          |
|POLY 3             |     P=0.168N     P=0.346      P=0.627N     P=0.551N    |P=0.417N     P=0.137      P=0.554      (e)          |
|POLY 1.5           |     P=0.162N     P=0.332      P=0.586N     P=0.534N    |P=0.400N     P=0.134      P=0.537      (e)          |
|POLY 6             |     P=0.176N     P=0.359      P=0.672N     P=0.572N    |P=0.435N     P=0.142      P=0.577      (e)          |
|LOGISTIC REGRESSION|     P=0.175N     P=0.340      (e)          (e)         |P=0.386N     P=0.117      P=0.523      (e)          |
|COCH-ARM / FISHERS |     P=0.153N     P=0.309      P=0.500N     P=0.500N    |P=0.362N     P=0.125      P=0.505      (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    0/39 (0%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          458          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.578      (e)          P=0.197      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.615      (e)          P=0.252      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.608      (e)          P=0.245      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.621      (e)          P=0.261      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.620      (e)          P=0.275      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    3/50 (6%)    0/49 (0%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.9%         6.3%         0.0%         4.5%        |6.7%         4.5%         0.0%         0.0%         |
|TERMINAL (d)       |     3/40 (8%)    3/44 (7%)    0/29 (0%)    2/39 (5%)   |2/32 (6%)    1/32 (3%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     547          729 (T)      ---          729 (T)     |714          703          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.227N     P=0.451N     P=0.107N     P=0.346N    |P=0.041N*    P=0.513N     P=0.112N     P=0.129N     |
|POLY 3             |     P=0.221N     P=0.478N     P=0.107N     P=0.360N    |P=0.047N*    P=0.524N     P=0.142N     P=0.155N     |
|POLY 1.5           |     P=0.210N     P=0.480N     P=0.090N     P=0.349N    |P=0.045N*    P=0.510N     P=0.134N     P=0.143N     |
|POLY 6             |     P=0.234N     P=0.477N     P=0.129N     P=0.375N    |P=0.050N     P=0.544N     P=0.152N     P=0.169N     |
|LOGISTIC REGRESSION|     P=0.206N     P=0.488N     P=0.069N     P=0.330N    |P=0.044N*    P=0.511N     P=0.127N     P=0.137N     |
|COCH-ARM / FISHERS |     P=0.190N     P=0.489N     P=0.059N     P=0.329N    |P=0.039N*    P=0.500N     P=0.121N     P=0.121N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.3%        |2.2%         4.5%         6.8%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    1/32 (3%)    1/36 (3%)    0/32 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |714          703          622          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.194      (e)          (e)          P=0.495     |P=0.358N     P=0.484      P=0.312      P=0.522N     |
|POLY 3             |     P=0.216      (e)          (e)          P=0.548     |P=0.397N     P=0.527      P=0.323      P=0.580N     |
|POLY 1.5           |     P=0.210      (e)          (e)          P=0.533     |P=0.381N     P=0.520      P=0.316      P=0.555N     |
|POLY 6             |     P=0.222      (e)          (e)          P=0.562     |P=0.414N     P=0.535      P=0.333      P=0.611N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.495     |P=0.341N     P=0.498      P=0.307      P=0.513N     |
|COCH-ARM / FISHERS |     P=0.200      (e)          (e)          P=0.505     |P=0.337N     P=0.500      P=0.309      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    1/50 (2%)    1/50 (2%)    2/49 (4%)   |5/50 (10%)   2/50 (4%)    2/48 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.5%         2.1%         2.6%         4.4%        |10.9%        4.5%         4.6%         4.8%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     464          710          519          246         |264          662          543          616          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.493N     P=0.289N     P=0.357N     P=0.504N    |P=0.223N     P=0.242N     P=0.240N     P=0.261N     |
|POLY 3             |     P=0.505N     P=0.303N     P=0.417N     P=0.523N    |P=0.221N     P=0.240N     P=0.254N     P=0.274N     |
|POLY 1.5           |     P=0.494N     P=0.301N     P=0.378N     P=0.511N    |P=0.214N     P=0.227N     P=0.247N     P=0.258N     |
|POLY 6             |     P=0.521N     P=0.307N     P=0.460N     P=0.541N    |P=0.227N     P=0.256N     P=0.263N     P=0.290N     |
|LOGISTIC REGRESSION|     P=0.437N     P=0.421N     P=0.145N     P=0.573N    |P=0.154N     P=0.253N     P=0.231N     P=0.188N     |
|COCH-ARM / FISHERS |     P=0.476N     P=0.301N     P=0.301N     P=0.500N    |P=0.189N     P=0.218N     P=0.235N     P=0.218N     |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         2.7%         4.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    1/44 (2%)    0/29 (0%)    1/39 (3%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          729 (T)      700          700         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.141      P=0.519      P=0.439      P=0.232     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.156      P=0.548      P=0.560      P=0.264     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.155      P=0.531      P=0.537      P=0.255     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.157      P=0.564      P=0.585      P=0.274     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.146      P=0.519      P=0.471      P=0.236     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.153      P=0.500      P=0.500      P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         6.8%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    0/44 (0%)    0/29 (0%)    3/39 (8%)   |0/32 (0%)    0/32 (0%)    0/36 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.079      P=0.481N     P=0.564N     P=0.296     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.082      P=0.521N     P=0.627N     P=0.325     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.082      P=0.514N     P=0.586N     P=0.318     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.081      P=0.530N     P=0.672N     P=0.331     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.079      (e)          (e)          P=0.296     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.086      P=0.500N     P=0.500N     P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   3/50 (6%)    5/50 (10%)  |13/50 (26%)  6/50 (12%)   15/50 (30%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     13.5%        18.8%        8.0%         11.3%       |29.0%        13.5%        33.9%        31.1%        |
|TERMINAL (d)       |     6/40 (15%)   8/44 (18%)   3/29 (10%)   4/39 (10%)  |11/32 (34%)  5/32 (16%)   13/36 (36%)  11/32 (34%)  |
|FIRST INCIDENCE    |     729 (T)      665          729 (T)      700         |683          710          543          642          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.328N     P=0.360      P=0.420N     P=0.519N    |P=0.292      P=0.064N     P=0.532      P=0.581      |
|POLY 3             |     P=0.297N     P=0.349      P=0.366N     P=0.519N    |P=0.228      P=0.064N     P=0.404      P=0.522      |
|POLY 1.5           |     P=0.286N     P=0.328      P=0.327N     P=0.513N    |P=0.238      P=0.059N     P=0.403      P=0.538      |
|POLY 6             |     P=0.311N     P=0.370      P=0.413N     P=0.529N    |P=0.223      P=0.071N     P=0.406      P=0.510      |
|LOGISTIC REGRESSION|     P=0.318N     P=0.349      P=0.420N     P=0.520N    |P=0.204      P=0.073N     P=0.366      P=0.470      |
|COCH-ARM / FISHERS |     P=0.262N     P=0.288      P=0.243N     P=0.500N    |P=0.296      P=0.062N     P=0.412      P=0.590N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/4 (100%)   3/3 (100%)   4/4 (100%)   7/7 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       100.0%       100.0%      |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/4 (100%)   3/3 (100%)   4/4 (100%)   7/7 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/49 (6%)    1/50 (2%)   |0/48 (0%)    0/49 (0%)    1/48 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         7.7%         2.3%        |0.0%         0.0%         2.4%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/44 (0%)    0/29 (0%)    1/39 (3%)   |0/32 (0%)    0/31 (0%)    0/35 (0%)    0/32 (0%)    |
|FIRST INCIDENCE    |     578          ---          408          729 (T)     |---          ---          697          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.455      P=0.483N     P=0.270      P=0.757     |P=0.681      (e)          P=0.489      (e)          |
|POLY 3             |     P=0.465      P=0.521N     P=0.286      P=0.782     |P=0.714      (e)          P=0.548      (e)          |
|POLY 1.5           |     P=0.466      P=0.513N     P=0.287      P=0.775     |P=0.706      (e)          P=0.532      (e)          |
|POLY 6             |     P=0.462      P=0.529N     P=0.285      P=0.788     |P=0.727      (e)          P=0.569      (e)          |
|LOGISTIC REGRESSION|     P=0.515      P=0.571N     P=0.454      P=0.760N    |P=0.694      (e)          P=0.500      (e)          |
|COCH-ARM / FISHERS |     P=0.469      P=0.500N     P=0.301      P=0.753N    |P=0.696      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.2%         2.2%         0.0%         7.2%         |
|TERMINAL (d)       |                                                        |1/32 (3%)    0/32 (0%)    0/36 (0%)    2/32 (6%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      707          ---          606          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.155      P=0.754      P=0.477N     P=0.302      |
|POLY 3             |                                                        |P=0.164      P=0.786      P=0.561N     P=0.311      |
|POLY 1.5           |                                                        |P=0.161      P=0.775N     P=0.541N     P=0.307      |
|POLY 6             |                                                        |P=0.168      P=0.796      P=0.587N     P=0.318      |
|LOGISTIC REGRESSION|                                                        |P=0.149      P=0.760      (e)          P=0.289      |
|COCH-ARM / FISHERS |                                                        |P=0.160      P=0.753N     P=0.500N     P=0.309      |
|=================================================================================================================================|
       Date:  08/01/97                           EXPERIMENT: 05160 TEST: 06                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -           1-CHLORO-2-PROPANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        250 PPM      500 PPM      1000 PPM    |0 PPM        250 PPM      500 PPM      1000 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |41/50 (82%)  46/50 (92%)  43/50 (86%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|                                                        |86.9%        95.5%        90.5%        96.2%        |
|TERMINAL (d)       |                                                        |29/32 (91%)  31/32 (97%)  33/36 (92%)  32/32 (100%) |
|FIRST INCIDENCE    |                                                        |465          538          393          466          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.350      P=0.206      P=0.491N     P=0.272      |
|POLY 3             |                                                        |P=0.121      P=0.120      P=0.416      P=0.101      |
|POLY 1.5           |                                                        |P=0.133      P=0.137      P=0.385      P=0.115      |
|POLY 6             |                                                        |P=0.131      P=0.109      P=0.445      P=0.106      |
|LOGISTIC REGRESSION|                                                        |P=0.089      P=0.120      P=0.308      P=0.076      |
|COCH-ARM / FISHERS |                                                        |P=0.361      P=0.117      P=0.393      P=0.288      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).