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TDMS Study 05160-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 07/30/97       
EXPERIMENT: 05160 TEST: 06                                                                                     TIME: 08:56:43       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C       
PATHOLOGIST: F. VOELKER                                                                                        CAS: 127-00-4        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           2 YEAR CHRONIC                                                           
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: TSI Mason Research                                   1-CHLORO-2-PROPANOL                                  DATE: 07/30/97      
EXPERIMENT: 05160 TEST: 06                                                                                     TIME: 08:56:43      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-05300                              ROUTE: DOSED WATER                                             NTP C#: 61983C      
PATHOLOGIST: F. VOELKER                                                                                        CAS: 127-00-4       
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      220   380   464   501   518   547   578   646   708   714                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      335   471   645   665   700   710                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 5    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      377   408   458   458   484   519   519   602   607   608                 |
 |      625   637   638   645   700   714                                         |
 |  CENSORED DEATHS                                                               |
 |      79    92    180   189   511                                               |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 8      CENSORED DEATHS 3    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      443   543   556   568   645   652   657   700                             |
 |  CENSORED DEATHS                                                               |
 |      233   246   617                                                           |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0  98.0  98.0  96.0  94.0  90.0  86.0  84.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |250 PPM    |   100.0 100.0 100.0  98.0  98.0  96.0  96.0  96.0  92.0  88.0      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0  95.7  89.1  84.7  82.4  69.1  64.6      |
 |           |                                                                    |
 |           |                                                                    |
 |1000 PPM   |   100.0 100.0 100.0 100.0 100.0  97.9  95.8  91.7  85.3  83.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        250 PPM      500 PPM      1000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       80.0%        88.0%        64.6%        83.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.986      P=0.386N     P=0.151      P=0.824N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       527.6        587.7        562.4        595.5    |
 |NATURAL DEATHS (C)      |       (47.8)       (61.7)       (25.8)       (29.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       688.7        712.0        623.8        685.8    |
 |(STANDARD ERROR)        |       (14.7)       ( 9.5)       (24.9)       (15.5)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 3    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      465   587   593   657   670   673   677   683   683   714                 |
 |      721   726   731   732   733                                               |
 |  CENSORED DEATHS                                                               |
 |      76    264   698                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      449   449   538   575   582   594   647   662   663   668                 |
 |      691   695   703   704   707   710   712   732                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 1    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      50    393   540   543   622   633   645   645   646   649                 |
 |      655   689   697                                                           |
 |  CENSORED DEATHS                                                               |
 |      113                                                                       |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 2    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      150   238   466   523   569   606   616   629   642   646                 |
 |      664   681   681   701   717   734                                         |
 |  CENSORED DEATHS                                                               |
 |      77    261                                                                 |
 |                                                                                |
 ==================================================================================
                                1-CHLORO-2-PROPANOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0  97.9  97.9  93.8  91.7  68.4      |
 |           |                                                                    |
 |           |                                                                    |
 |250 PPM    |   100.0 100.0 100.0 100.0 100.0  96.0  94.0  88.0  82.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |    98.0  98.0  98.0  98.0  96.0  96.0  91.9  91.9  77.6  73.5      |
 |           |                                                                    |
 |           |                                                                    |
 |1000 PPM   |   100.0  98.0  95.9  95.9  95.9  93.8  91.7  89.7  77.2  66.7      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        250 PPM      500 PPM      1000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.4%        64.0%        73.5%        66.7%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.888      P=0.650      P=0.944N     P=0.812  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       669.7        637.8        569.8        578.9    |
 |NATURAL DEATHS (C)      |       (18.8)       (20.7)       (48.8)       (41.6)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       692.1        700.0        679.6        662.4    |
 |(STANDARD ERROR)        |       (17.0)       ( 9.9)       (19.8)       (22.1)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        1-CHLORO-2-PROPANOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        250 PPM          = 2
                                                        500 PPM          = 3
                                                        1000 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         |
         |
  102.50 +
         |
         |1                                  1                 2     3          4
         |
   98.04 +                                   1                 2     3 1   3    4    2          4
         |
         |                                                             1   3       312          4 4             2
         |
   93.59 +                                                                          1    1        4 4           2  2
         |                                                                               1 1                       2    2
P        |                                                                         3   3            4           4
E        |                                                                                 1     1                      2 2
R  89.13 +                                                                             3     3                  44
C        |                                                                                       1   1                    2   2
E        |
N        |                                                                                           1          14      4
T  84.67 +                                                                                   3           3
         |                                                                                                      1       4 1   4
S        |                                                                                               33
U        |
R  80.22 +                                                                                                                1   1
V        |
I        |                                                                                                3  3
V        |
A  75.76 +                                                                                                   33
L        |
         |                                                                                                    33
         |
   71.30 +                                                                                                     33
         |
         |                                                                                                      3       3
         |
   66.85 +                                                                                                              3 3
         |
         |                                                                                                                3   3
         |
   62.39 +
         |
         -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
          0         10         20         30         40         50         60         70         80         90         100       110

                                                                     WEEK

NOTE: 3 obs hidden.
                                                        1-CHLORO-2-PROPANOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        250 PPM          = 2
                                                        500 PPM          = 3
                                                        1000 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1        3              4                                               2 1
      |
      |          3              4            4                         3          1                 1
      |                                      4                         3        2 4          23     1 1
   95 +
      |                                                                           4        4 2     2  1        1
      |                                                                                       3    22     3
      |                                                                                    4      4            1  1
P  90 +                                                                                           4 2 2 4 3 3     11
E     |
R     |                                                                                               2 44  3 2
C     |                                                                                                       2  2
E  85 +                                                                                                  4 4       11
N     |                                                                                                    4 4
T     |                                                                                                          22
      |                                                                                                      44     1   1
S  80 +                                                                                                       33  2  2
U     |                                                                                                       4  4      11
R     |                                                                                                        3 4  422  11
V     |                                                                                                               22
I  75 +                                                                                                              33   1 1
V     |                                                                                                               3     3
A     |                                                                                                             4  4
L     |                                                                                                                4 4
   70 +                                                                                                                22
      |                                                                                                                  4  1
      |
      |                                                                                                                 2   2
   65 +
      |                                                                                                                     2
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 7 obs hidden.