TDMS Study 05161-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst RIDDELLIINE DATE: 12/15/00
EXPERIMENT: 05161 TEST: 05 TIME: 12:15:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55393 ROUTE: GAVAGE NTP C#: 61358C
PATHOLOGIST: HEATH, JAMES E. CAS: 23246-96-0
------------------------------------------------------------------------------------------------------------------------------------
RATS/FINAL#1_FEMALES
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 003 0 MG/KG/DY
INCLUDE 004 0.01 MG/KG/DY
INCLUDE 005 0.033 MG/KG/DY
INCLUDE 006 0.1 MG/KG/DY
INCLUDE 007 0.33 MG/KG/DY
INCLUDE 008 1.0 MG/KG/DY
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst RIDDELLIINE DATE: 12/15/00
EXPERIMENT: 05161 TEST: 05 TIME: 12:15:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55393 ROUTE: GAVAGE NTP C#: 61358C
PATHOLOGIST: HEATH, JAMES E. CAS: 23246-96-0
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 2 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 393 437 468 483 498 545 611 611 636 640 |
| 672 678 693 710 720 |
| CENSORED DEATHS |
| 626 654 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 6 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 328 407 513 520 541 573 600 605 631 638 |
| 644 647 650 672 675 679 693 698 715 718 |
| 719 725 |
| CENSORED DEATHS |
| 519 612 613 636 636 643 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.033 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 3 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 437 518 532 562 571 572 591 591 616 617 |
| 647 647 654 671 675 688 694 715 715 |
| CENSORED DEATHS |
| 444 647 658 |
| |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.1 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 2 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 252 307 451 552 561 618 638 638 642 646 |
| 650 651 658 660 664 678 678 680 682 691 |
| 707 707 710 715 718 726 |
| CENSORED DEATHS |
| 293 668 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.33 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 3 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 451 463 524 570 576 581 587 590 602 619 |
| 630 654 656 671 680 686 686 697 |
| CENSORED DEATHS |
| 654 657 658 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 350 352 393 400 405 407 423 426 434 440 |
| 447 459 460 461 461 469 470 472 475 476 |
| 478 487 488 503 506 509 516 522 527 528 |
| 528 528 541 542 548 552 552 552 552 556 |
| 569 573 581 587 587 591 608 618 658 668 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 98.0 92.0 88.0 88.0 79.9 69.4 |
|MG/KG/DY | |
| | |
|0.01 | 100.0 100.0 100.0 98.0 96.0 96.0 89.9 83.8 72.4 51.4 |
|MG/KG/DY | |
| | |
|0.033 | 100.0 100.0 100.0 100.0 100.0 98.0 93.9 83.7 73.4 60.5 |
|MG/KG/DY | |
| | |
|0.1 | 100.0 100.0 98.0 96.0 96.0 93.9 93.9 89.8 69.4 46.3 |
|MG/KG/DY | |
| | |
|0.33 | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 82.0 73.9 63.1 |
|MG/KG/DY | |
| | |
|1.0 | 100.0 100.0 100.0 96.0 86.0 58.0 32.0 8.0 2.0 0.0 |
|MG/KG/DY | |
| | |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 0.01 0.033 0.1 0.33 1.0 |
| MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 69.4% 51.4% 60.5% 46.3% 63.1% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.166 P=0.513 P=0.063 P=0.641 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 586.3 617.8 616.5 626.2 606.8 504.7 |
|NATURAL DEATHS (C) | (27.7) (22.0) (16.9) (23.2) (17.2) (10.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.6 665.8 677.5 665.6 680.7 504.7 |
|(STANDARD ERROR) | (12.4) (12.6) (11.0) (15.9) (10.3) (10.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RIDDELLIINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
0.01 MG/KG/DY = 2
0.033 MG/KG/DY = 3
0.1 MG/KG/DY = 4
0.33 MG/KG/DY = 5
1.0 MG/KG/DY = 6
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
112 +
|
|
| 1 4 4 2 66 1 2 1 5 5 3
96 + 4 6 662 1 4 1 1 2 23 5
| 66 4 1 1 23 14 335
P | 6 6 1 4255 32 14 4
E | 666 32215 1
R 80 + 66 6 3351135 1
C | 223 11 1
E | 66 23 42251 11
N | 66 4 3 33 1 1
T 64 + 2422 3 5
| 666 4424 2 3
S | 6 6 44
U | 66 422 2
R 48 + 66 6 44 4
V | 66
I |
V | 6 6
A 32 + 66
L |
| 66
| 6 6
16 + 666
| 6 6
| 6 6 6
| 6 6 6
0 + 6
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 78 obs hidden.