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TDMS Study 05161-06 Pathology Tables

NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01
Route: GAVAGE                                                                                                     Time: 09:06:02

                                                            FINAL#2




       Facility:  Southern Research Institute

       Chemical CAS #:  23246-96-0

       Lock Date:  11/17/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|             
                                           | 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Cyst                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                      X                                                   |             
      Eosinophilic Focus                   |                                                       X                  |             
      Hyperplasia, Focal, Lymphoid         |                                                 2                        |             
      Infiltration Cellular, Mixed Cell    |       1     2  2     1  1  1  3  2  1                    1        2  2   |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Hepatocyte, Mixed Cell Focus         |                                                                         2|             
      Hepatocyte, Necrosis, Focal          |                      1  1           1                                2   |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                   3                    3              3                  |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                                                 1  2                     |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +  +                 +  +        +  +        +     +        +     +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|             
                                           | 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Artery, Inflammation, Chronic, Focal |                                                                          |             
      Fat, Necrosis                        |    2  2                 1  3        2           2     3              2  3|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                3         |             
      Atrophy, Focal                       |                                                                3         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  | 3                                                                        |             
      Ulcer                                | 2                                                                        |             
      Epithelium, Cyst                     |                                                                          |             
      Epithelium, Hyperplasia              | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +           +                       +           +              +      |             
      Malformation                         |                                        2                                 |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |    1           2                                   3              2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          1                                                               |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Bilateral, Hypertrophy, Focal        |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                         2                                                |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|             
                                           | 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3              2                  |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |          2                                                               |             
      Pars Distalis, Hyperplasia, Focal    |                                  2                                       |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |       3  2           2                             1           3     2  2|             
      Inflammation, Chronic, Focal         |                                                          1               |             
      Follicle, Cyst                       |                         2                                                |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3                                 |             
      Cyst                                 |          2           3  3                 3           1     3        3   |             
      Hemorrhage                           |                                                 2                        |             
      Mineralization                       |                                                          1               |             
      Pigmentation, Focal                  |                                                          2               |             
      Bilateral, Cyst                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                          3               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |          3  3  3  3     2        3  3     3                 4     3     3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|             
                                           | 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation, Suppurative            |                   3                          2                           |             
      Endometrium, Hyperplasia, Cystic     |       3  3  3  3  3  1  2        3  3  3  3  4  3  3  3  3  3  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                4         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                               +        +  +                    +         |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Iliac, Hemorrhage                    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                               3                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                 3                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2              3                                                   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2     3  4  2  2  3     4  2  3  2  4  2           2     3     3  3|             
      Hyperplasia, Lymphoid                |                      2                          2           3           2|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Hyperplasia, Lymphoid                |                      3              2                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                      2   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|             
                                           | 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
           Focal, Suppurative              |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Hyperostosis, Focal        | 3     3  3  3  3     3  3        2  3     3  3  3  3  3  3  3  3  3     2|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2        1                  |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Hyperplasia, Histiocytic             |                            3                                             |             
      Hyperplasia, Lymphoid                |                      2                                2                  |             
      Pigmentation, Focal                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
      Interstitium, Edema                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |       +                                      +                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|             
                                           | 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
      Cyst                                 |                                  2                 2                     |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Mineralization, Focal                |                                                                3         |             
      Nephropathy                          |       1  1  1  1              1  1  2     3           1        3        1|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                        3                       2         |             
      Renal Tubule, Casts Protein          |                   2                                                      |             
      Renal Tubule, Dilatation             |                                              1                       1   |             
      Renal Tubule, Hemorrhage             |                                                                2         |             
      Renal Tubule, Necrosis               |                   2                                                      |             
      Renal Tubule, Pigmentation           |                                        1                       3         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    3                                                                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                   1      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  M  A  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Epithelium, Cyst                     |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                  2        2                              |      2  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |          X                                                               |      2     |
      Hyperplasia, Focal, Lymphoid         |       2                                                                  |      2  2.0|
      Infiltration Cellular, Mixed Cell    | 3     1     1     1           1     2     2  1  1  1  1  1  1  1  1  1  1|     29  1.4|
      Inflammation, Focal, Suppurative     |    2                                                                     |      1  2.0|
      Mineralization, Focal                |                                                                         1|      1  1.0|
      Hepatocyte, Mixed Cell Focus         |                                                                          |      1  2.0|
      Hepatocyte, Necrosis, Focal          |    2  1     1                             1  2           1  1  1         |     12  1.3|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |          3        3  3  3  3                                             |      8  3.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                            2                                             |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +        +           +  +        +  +  +     +     +        +     +  +   |  23        |
      Artery, Inflammation, Chronic, Focal |                                              3                           |      1  3.0|
      Fat, Necrosis                        |          3           1  1        3  2  3           3        3     4  4   |     19  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Atrophy, Focal                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic        |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal                  |    1                                                                     |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Cyst                     |                         1                                                |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                          +  +            |   7        |
      Malformation                         |                                                                          |      1  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                          1  2            |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    | 2                                   1  2                                 |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                                                1         |      1  1.0|
      Bilateral, Hypertrophy, Focal        |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atypia Cellular                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Cyst                                 |                                                       2                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                 3                    2   |      4  2.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                        2           2                     |      3  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic, Focal          | 2                                      1        1     1     2  2         |     13  1.8|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                           3                 2            |      3  2.7|
      Cyst                                 |    3  3              3     3  3     3                    1           2   |     15  2.6|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Bilateral, Cyst                      |                                                    3                     |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                3         |      1  3.0|
      Hydrometra                           |    3  3  3  3  3  3  3  3     3  3  3                 3     4     3  3  3|     27  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |    3  3  3  3     2  3  3  3  3     3  3  3  3  2  3  3  3  3  3  2  3  3|     43  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     3                                    |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                +           +                           |   7        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Iliac, Hemorrhage                    |                                              3                           |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Hyperplasia, Plasma Cell             |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Plasma Cell             |    4        2           3                                                |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     | 3  2  3  2  3        3  2     2     2  2        2           2  2  4  2  2|     32  2.6|
      Hyperplasia, Lymphoid                |          3                          2  2        3     3                  |      9  2.4|
      Hyperplasia, Plasma Cell             |    3                                                                     |      1  3.0|
      Pigmentation                         |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                2         |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Suppurative              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Hyperostosis, Focal        | 3  3  3  3  3           3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|     41  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    1                                                                     |      3  1.3|
      Foreign Body                         |                   3  2  3  2                                             |      4  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                           2                              |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Pigmentation, Focal                  |                                           2                              |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Interstitium, Edema                  |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      |                   1                                                      |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
      Atrophy                              |                                                                   4      |      1  4.0|
      Inflammation, Chronic                |                                                                   4      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                    +      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                    2                     |      3  2.0|
      Metaplasia, Focal, Osseous           |             1                                                            |      1  1.0|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Nephropathy                          | 1                    1  1        1  1        1     1                     |     18  1.3|
      Artery, Inflammation, Chronic        |                                              4                           |      1  4.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  2.5|
      Renal Tubule, Casts Protein          |                                                                2         |      2  2.0|
      Renal Tubule, Dilatation             |                                                                          |      2  1.0|
      Renal Tubule, Hemorrhage             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0                                      | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Epithelium, Cytoplasmic Alteration   |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |             1                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage, Focal                    |                                                                   3      |             
      Artery, Inflammation, Chronic, Focal |          1                                2  2  2  2  1  1        2     2|             
      Epithelium, Erosion, Focal           |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Artery, Inflammation, Chronic        |          1           2                    2  2     2  1  1              2|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2                                             |             
      Congestion, Focal                    |                                  2                                       |             
      Cyst                                 | 2                                                                        |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage, Focal                    |    3                             2                                       |             
      Infarct                              |    3                                                                     |             
      Infiltration Cellular, Mixed Cell    | 2  3  1  2  2     2  2  2     1  2  2  1  2  2  2  2  2  2  2  2  1     2|             
      Pigmentation, Focal                  |                            2                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Thrombosis                           | 2                                                                        |             
      Artery, Inflammation, Chronic        |             1                                                            |             
      Bile Duct, Hyperplasia               | 2     2  1        2     1  2  1     2     2  2  2        2  3        2   |             
      Endothelial Cell, Hyperplasia, Focal |                                                                          |             
      Hepatocyte, Cytomegaly               | 3  3     3  2  3  3  2  3  1  1  3  3  2  2  3  2  3  2  2  1  2  3  3  3|             
      Hepatocyte, Karyomegaly              | 3  3     3  2  3  3  2  3  1  1  3  3  2  2  3  2  3  2  2  1  2  3  3  3|             
      Hepatocyte, Necrosis, Focal          | 2           1                 1  2           1        1        1         |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                3                                                         |             
      Hepatocyte, Centrilobular, Necrosis  |                   3                                                      |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                   3        3                 2                           |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                                 2              2         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +  +     +  +  +  +                 +  +  +  +  +  +     +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal,        |                                                                          |             
          Suppurative                      |                                                                          |             
      Inflammation, Chronic                |                                                          3               |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic, Focal |          2           3                    3  3  2  2  2  3     2  2     3|             
      Artery, Mineralization, Focal        |                                                                          |             
      Fat, Necrosis                        |                1                                      1                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                        4                                 |             
      Acinus, Atrophy, Focal               |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Inflammation, Chronic                |                                                                          |             
      Aorta, Mineralization                |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |       1                                                                  |             
      Inflammation, Chronic, Focal         |                                                                         2|             
      Mineralization, Focal                |                                                 3        2     2         |             
      Epicardium, Infiltration Cellular,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 1                                                                        |             
      Angiectasis                          |                                                                          |             
      Cytoplasmic Alteration, Focal        | 2     2  2  1     1        3        3  2     2     4  2  3              2|             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic, Focal         |                      2                    3                       2     2|             
      Thrombosis                           |                                                                          |             
      Capsule, Fibrosis, Focal             |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
          Alteration, Focal                |                                     1                                    |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |          2        3     3  1  2     3  2                       1  1     3|             
      Inflammation, Chronic, Focal         | 2                    1                                                   |             
      Follicular Cell, Cytoplasmic         |                                                                          |             
          Alteration, Diffuse              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
      Abdominal, Inflammation              |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                   2  3                                                   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | 2     2  3                    2  2  2                                   3|             
      Cyst, Multiple                       |                                                                          |             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                      2                                                   |             
      Artery, Inflammation, Chronic        |          2           3                 1  3  3  2  3  2  2  3  3  3     3|             
      Bilateral, Cyst                      |                2     3                                                   |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |             3           2  2  3        2     2              3  3  3  3  3|             
      Artery, Inflammation, Chronic, Focal |          1  3        3                    2  2  3     2  2     2  2      |             
      Artery, Inflammation                 |                                                    3                     |             
      Endometrium, Hyperplasia, Cystic     | 3  2  2  3     3  3  3     2  3  2  3  3  3  3  3  3  3     3  3  3  3  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                         +                          +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4                                3                    3               |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +     +           +                    +           +   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Bronchial, Hyperplasia, Lymphoid     |                                     2                                    |             
      Bronchial, Hyperplasia, Plasma Cell  |    3                                                                     |             
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |    4                                                                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|    3                                                                     |             
      Renal, Angiectasis                   |                                                                      4   |             
      Renal, Hemorrhage                    |                                                          4           4   |             
      Renal, Hyperplasia, Plasma Cell      |    4                                                                     |             
      Renal, Inflammation, Suppurative     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3           2        3        2                     |             
      Hemorrhage                           |                                                    2     3     3         |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Hyperplasia, Plasma Cell             |                                                                      3   |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  4  3  4  3     3  3     3  2  3  3  2  3  3  3  3  3  3  3  3  4     3|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Artery, Inflammation, Chronic, Focal |             3                                                            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  +  I  +  +  +  +  +  M  M  +  +  M  +  I  +|             
      Atrophy                              |                                                                   3      |             
      Cyst                                 |    2                                                                     |             
      Hyperplasia, Histiocytic             |                         3                                                |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3                                                            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Subcutaneous Tissue,         |                                                                          |             
          Inflammation, Chronic            |                                                                         2|             
      Dermis, Edema, Focal                 |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                      2                                                   |             
      Vertebra, Hyperostosis, Focal        | 3     3  3  3     3  3  3  3     3  3        2  3  3  3  3  3           3|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Gliosis                              |                1                                                         |             
      Hemorrhage, Focal                    |                2                                                         |             
      Artery, Meninges, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                   +                                                      |             
      Spinal, Ganglion, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                   +                                                      |             
      Hemorrhage, Focal                    |                                                                          |             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          3               |             
      Hemorrhage                           |                            2                                             |             
      Hyperplasia, Focal, Mast Cell        |                                                                          |             
      Hyperplasia, Histiocytic             |          2        2        2                                             |             
      Infiltration Cellular, Mixed Cell    |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                    1        2            |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic                         |                      2                                                   |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|             
                                           | 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Focal, Osseous           |          2  1                          2           1              2      |             
      Mineralization, Focal                |                                                 3                        |             
      Nephropathy                          | 3     3  4  3  2  4  4  3  4  2  3  3  2  4  4  4  4  4  4  4  4  4  2  3|             
      Artery, Inflammation, Chronic        |                      3           3     2                                2|             
      Artery, Mineralization               |                                                 1                        |             
      Glomerulus, Glomerulosclerosis       | 3     2  3  2     3        2  2  3  1     3  3  3  4  3  3  3  2  3     3|             
      Pelvis, Dilatation                   |                                                                      3   |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                2  2      |             
      Renal Tubule, Dilatation             |                                     1                                    |             
      Renal Tubule, Karyomegaly            |             2                                                            |             
      Renal Tubule, Pigmentation           |          3  1        3     2     2        3  3     3  3  2  3  3  3     2|             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                      +   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                         3|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
      Cyst                                 |    2                          1                                          |      2  1.5|
      Epithelium, Cytoplasmic Alteration   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Edema                                |       3                 3           3           3  3                     |      5  3.0|
      Hemorrhage, Focal                    |       3                 2           2           2  2                     |      6  2.3|
      Artery, Inflammation, Chronic, Focal |       2           2     1     2  2  1           2  2  2                  |     18  1.7|
      Epithelium, Erosion, Focal           |       2                 1           3           2  1                     |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Hemorrhage, Focal                    |                                  3        2                              |      2  2.5|
      Necrosis, Focal                      |                                  4        2                              |      2  3.0|
      Artery, Inflammation, Chronic        |             2  2  2              3        3                              |     13  1.9|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2                                                                  |      2  2.0|
      Congestion, Focal                    |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                            2                             2               |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hemorrhage, Focal                    |                                                                          |      2  2.5|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |    2  2     2  2  1  2  2     2  2     1  2  1  1  2  2     1  1     3  2|     41  1.8|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    2  2           2     1  3  2  2        2  1        2  3  2  2     2   |     28  1.9|
      Endothelial Cell, Hyperplasia, Focal |                                                          3               |      1  3.0|
      Hepatocyte, Cytomegaly               | 2  3  2  2  2  3  2  2  2  3  3  1  2  1  3  2  3  2  2  2  2  2  1  3  1|     49  2.3|
      Hepatocyte, Karyomegaly              | 2  3  2  2  2  3  2  2  2  3  3  1  2  1  3  2  3  2  2  2  2  2  1  3  1|     49  2.3|
      Hepatocyte, Necrosis, Focal          |          4  1  1     2  1  2        2     2  1  1  1           2         |     19  1.5|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  3.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      3  2.7|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                                                 2                        |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +     +        +  +  +  +     +     +     +  +  +           +     +|  29        |
      Fibrosis, Focal                      |       3                    3                                             |      2  3.0|
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Inflammation, Chronic, Focal,        |                                                                          |            |
          Suppurative                      |                            2                                             |      1  2.0|
      Inflammation, Chronic                |                                                                   2      |      2  2.5|
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
      Artery, Inflammation, Chronic, Focal |             3           3     2           2     2  2  3                 4|     19  2.5|
      Artery, Mineralization, Focal        |                                                       2                  |      1  2.0|
      Fat, Necrosis                        |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                            3                                             |      1  3.0|
      Necrosis, Focal                      |                                                       2                  |      1  2.0|
      Acinus, Atrophy, Diffuse             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Acinus, Atrophy, Focal               |                                                 1                        |      1  1.0|
      Artery, Inflammation, Chronic        |             1  1           2                                             |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic        |                                                 2     3                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Cyst                                 |                                                                      2   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                         +|   2        |
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                      2  2     2     1                                2   |      6  1.7|
      Inflammation, Chronic, Focal         |                                                                2         |      2  2.0|
      Mineralization, Focal                |                                                       2                  |      4  2.3|
      Epicardium, Infiltration Cellular,   |                                                                          |            |
           Mixed Cell                      |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                            1                                             |      2  1.0|
      Angiectasis                          |                                                                      4   |      1  4.0|
      Cytoplasmic Alteration, Focal        |    1        2           1  2           2  3     1  2     2  3  1  X      |     25  2.0|
      Cytoplasmic Alteration               |                                              2                           |      1  2.0|
      Inflammation, Chronic, Focal         |                                                    3  1                  |      6  2.2|
      Thrombosis                           |                                                    3                     |      1  3.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|  46        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                          2               |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |       2        1                                                         |      3  1.3|
      Pars Distalis, Hemorrhage, Focal     |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic, Focal          |    2  2     1     1                 2  1  1        1     3  2           2|     21  1.9|
      Inflammation, Chronic, Focal         |                                                                          |      2  1.5|
      Follicular Cell, Cytoplasmic         |                                                                          |            |
          Alteration, Diffuse              | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Abdominal, Inflammation              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  48        |
      Angiectasis                          |             3                                                            |      1  3.0|
      Cyst                                 |       3           2                 2        3  3        2           3  4|     15  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst, Multiple                       |    3                                                        2            |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |    3  3     3  3  2     3     2  3        3     2  3  3                 2|     26  2.6|
      Bilateral, Cyst                      |                                                                          |      2  2.5|
      Interstitial Cell, Hyperplasia       |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                               2     2                                    |      2  2.0|
      Cyst                                 |                                           3                              |      1  3.0|
      Hemorrhage                           |                                                                3         |      1  3.0|
      Hydrometra                           |                   3     3        3  2     3     2        3  3            |     19  2.7|
      Artery, Inflammation, Chronic, Focal |    3  3     3  3  3              3        2     2  3           2        1|     21  2.4|
      Artery, Inflammation                 |                                                       3                  |      2  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  3  3        1        2     3  3     3  3  3  3  3  3  3  3  3  3  1  3|     41  2.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      3     2                                         3   |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                      +     +     +  +                             +  +   |  15        |
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Hyperplasia, Histiocytic             |                                  3                                       |      1  3.0|
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Bronchial, Hyperplasia, Plasma Cell  |                                                                          |      1  3.0|
      Deep Cervical, Hyperplasia, Lymphoid |                                                                      3   |      1  3.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                   3      |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                      3                                                   |      2  3.0|
      Renal, Angiectasis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Renal, Hemorrhage                    |                                                                          |      2  4.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
      Renal, Inflammation, Suppurative     |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Fibrosis                             |                            4                                             |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Fibrosis                             |                            4                                             |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Hemorrhage                           |                                  2                                       |      4  2.5|
      Hyperplasia, Histiocytic             |                      3           3                                       |      2  3.0|
      Hyperplasia, Lymphoid                |                                                          2               |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |    4  3  3  3  4  3  4  3  4  3  3  4     3  2  3  3  4        2  3  4  2|     43  3.1|
      Hyperplasia, Lymphoid                |                                              2           3  2            |      4  2.5|
      Artery, Inflammation, Chronic, Focal |             2           1  2     1                    3                  |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +  I  +  M  I  +  +|  39        |
      Atrophy                              |                               2                                          |      2  2.5|
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Ectasia                              |       3                                                                  |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Subcutaneous Tissue,         |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  2.0|
      Dermis, Edema, Focal                 |                                     3                                    |      1  3.0|
      Subcutaneous Tissue, Edema           |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1  2.0|
      Vertebra, Hyperostosis, Focal        |    3  3     3  2  3     3     3  3     3  3     3  3     3  2     3  2   |     33  2.9|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                   +|   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       | 4                                                                        |      1  4.0|
      Gliosis                              |                                                                          |      1  1.0|
      Hemorrhage, Focal                    |       2     2           2                                                |      4  2.0|
      Artery, Meninges, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |             +     +     +     +                                         +|   6        |
      Spinal, Ganglion, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |             +     +     +     +                                         +|   6        |
      Hemorrhage, Focal                    |             1                                                            |      1  1.0|
      Meninges, Inflammation, Chronic      |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                       3                  |      2  3.0|
      Hemorrhage                           |       3                    2                                2            |      4  2.3|
      Hyperplasia, Focal, Mast Cell        |                                                          2               |      1  2.0|
      Hyperplasia, Histiocytic             |       3                             2        1              2  2  3      |      9  2.1|
      Infiltration Cellular, Mixed Cell    |                      2              3                                    |      3  2.3|
      Alveolar Epithelium, Hyperplasia     |                               2        1                    2           1|      6  1.5|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic                         |                                  2                                       |      2  2.0|
      Mediastinum, Inflammation, Chronic   |                                                 2                        |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                      +                                                   |   1        |
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                   +     +                                                |   2        |
      Atrophy                              |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |       +                 +                    +              +            |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 1              2                                                         |      2  1.5|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4|            |
                             DAY ON TEST   | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3|            |
                                           | 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Metaplasia, Focal, Osseous           |       2                                1           1                     |      8  1.5|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Nephropathy                          |    4  4  2  4  4  4  3  4  3  4  4  3  2  4  3  4  4  4  2  3  4  3  3   |     47  3.4|
      Artery, Inflammation, Chronic        |    2  2     2  2  2     1  2  2  2        2        2  2                  |     16  2.1|
      Artery, Mineralization               |                                                                          |      1  1.0|
      Glomerulus, Glomerulosclerosis       | 2  3  3  1  3  3  3  3  3  3  3  3     1  3  3  4  3  3     1  3     2   |     40  2.7|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |    2  3        3  3     2     3  2  3     3     2  3                 3   |     14  2.6|
      Renal Tubule, Dilatation             |                                                    1                     |      2  1.0|
      Renal Tubule, Karyomegaly            |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |    3  3     3  3  3     3     3  3        3     3  3  3        3         |     27  2.8|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|             
                                           | 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  A  +  +  +  +  +  M|             
      Cyst                                 |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |          2                                                               |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Clear Cell Focus                     |                                  X                                   X   |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   | 2                                      X  X                              |             
      Fibrosis, Focal                      |                                  1                                       |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 2        2  1     1  1  1  1  1  1  2  1  1  1  1  1        1  1        2|             
      Mixed Cell Focus                     |    X                 X     X                                             |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                         1|             
      Hepatocyte, Eosinophilic Focus       |       1                                                                  |             
      Hepatocyte, Karyomegaly              |                                                                         1|             
      Hepatocyte, Necrosis, Focal          | 1           1     1        1  1                 1  1  1        1         |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Focal                           | 1  2  1  2  1  1  1  1  1  1  1  1  1  1  2  1     1  1  1     1     1  1|             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|             
                                           | 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
          Cytoplasmic, Focal               |    2  2        1     2     2     2              2              2         |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |       1        2     3                          2              2  2      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +  +     +  +        +                       +  +   |             
      Angiectasis                          |                                                                   2      |             
      Artery, Inflammation, Chronic, Focal |                                           2                              |             
      Fat, Necrosis                        |                      3  2     3  3                                   3   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Focal                  |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +     +     +     +        +  +        +     +     +  +  +   |             
      Malformation                         |       2  2  2                          1                       1  2  3   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         | 3        2  3     4     3     2           4        3     3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
      Inflammation, Chronic                |                                           3                              |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|             
                                           | 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        | 2     1        1  1        1     1              1        1        1      |             
      Hyperplasia, Focal                   |             1                                                            |             
      Hyperplasia                          |                                                                          |             
      Capsule, Hyperplasia, Focal          |    2                    2     2                 2                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 1                                                        1        2      |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                             1            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          | 2                                      1                 2     1  1      |             
      Follicular Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 | 3  3           3        4     3     3        3  3              3  3     2|             
                                           |__________________________________________________________________________|             
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|             
                                           | 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Dilatation                           |    3  3        3        2  3           2        3           3  3  2      |             
      Inflammation, Chronic                |                            2                                             |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
      Pancreatic, Hyperplasia, Lymphoid    | 2                                                                        |             
      Pancreatic, Hyperplasia, Plasma Cell | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                 2           2                                 |             
      Hyperplasia, Plasma Cell             | 3                                                           3            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2              2     1     3  2           2  2                 3|             
      Hyperplasia, Plasma Cell             | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 | 1                    1                          2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
      Vertebra, Hyperostosis, Focal        | 3  3  3  3  2  3  3  3  3  3  1  3  3  3  3  3  3  3     3     3  3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|             
                                           | 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                  3                                       |             
      Hyperplasia, Histiocytic             |                2                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Edema                  |                                                                          |             
      Mediastinum, Inflammation, Chronic   |          3                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                    +              +     +|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Cyst, Squamous                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           1     2  1                     |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Metaplasia, Focal, Osseous           |                1                    2                       1            |             
      Nephropathy                          | 2  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   |             
      Renal Tubule, Dilatation             |    1     1                 1     1  1        1           2  1     2  1   |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3|            |
                                           | 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |       3                                                                  |      1  3.0|
      Clear Cell Focus                     |       X                          X  X                 X                 X|      7     |
      Cyst                                 |                                              3                           |      1  3.0|
      Eosinophilic Focus                   |                            X  X                                X         |      6  2.0|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Infarct                              |                            4                                             |      1  4.0|
      Infiltration Cellular, Mixed Cell    | 1  3  1     3  1  3     1  1  1  1        3  1  1     1           1      |     33  1.4|
      Mixed Cell Focus                     |                                                                          |      3     |
      Bile Duct, Hyperplasia               |    2              2                                                      |      2  2.0|
      Hepatocyte, Cytomegaly               |                   2                             2        1               |      4  1.5|
      Hepatocyte, Eosinophilic Focus       |                      2                                                   |      2  1.5|
      Hepatocyte, Karyomegaly              |                   2                             2        1               |      4  1.5|
      Hepatocyte, Necrosis, Focal          |       1        1  3        1  1        3     2  1     1                  |     18  1.3|
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3|            |
                                           | 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
           Focal                           | 1     2        1        1     1  1  1  2  2  1  2     1  1  1        1  1|     38  1.2|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                            3                       2        3            |      3  2.7|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |       2                 2  2     2  2        2     2  1              2  2|     18  1.9|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                                     2                                2   |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +        +  +        +  +                                             |  12        |
      Angiectasis                          |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic, Focal |    2                                                                     |      2  2.0|
      Fat, Necrosis                        |    2        3           3  3                                             |      9  2.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis, Focal                      |    2                                                                     |      1  2.0|
      Necrosis, Focal                      |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                 1                        |      1  1.0|
      Inflammation, Focal                  |                                           2     1                        |      2  1.5|
      Ulcer                                |                                           2                              |      1  2.0|
      Epithelium, Hyperplasia              |                                           2     2                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Pigmentation, Focal                  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                    +  +  +  +        +        +  +     +     +   |  24        |
      Malformation                         |       4                       2     2        3        2              3   |     13  2.2|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |       2                    2  3  4                    3  2     1         |     16  2.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3|            |
                                           | 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                                    2  1                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytoplasmic Alteration, Focal        | 2     3        1                 1  2           2  1  1              1   |     18  1.3|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Hyperplasia                          |                                              2                           |      1  2.0|
      Capsule, Hyperplasia, Focal          |                                                       2                  |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  M  M  M  +  A  +  +  +  +  M  +  +  +  +  +|  41        |
      Cyst                                 |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                        1           1                     |      5  1.2|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                   1      |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic, Focal          |             1  2                             1                           |      8  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3|            |
                                           | 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                3         |      1  3.0|
      Degeneration, Cystic                 | 3  3     3  3                 3                 3                 3     3|     19  3.0|
                                           |__________________________________________________________________________|____________|
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |       3                             3        3                    3  3   |     15  2.8|
      Inflammation, Chronic                |                            3                                             |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                     +                                    |   2        |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |    4        3  3  3  2        2           2     2        2              2|     18  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3|            |
                                           | 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +|  42        |
      Cyst                                 |                         2                                2              2|      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                                 3                        |      1  3.0|
      Vertebra, Hyperostosis, Focal        | 3     3     2           3  3  3  3  3     3  3  3  3  3  3     2        3|     37  2.9|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      1  1.0|
      Interstitium, Edema                  |                                              2                           |      1  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3|            |
                                           | 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                               +                    +           +         |   6        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   1        |
      Cyst, Squamous                       |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | 2                          2        2                             2  2   |      8  1.8|
      Inflammation, Chronic, Focal         |                                              2                           |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      3  1.3|
      Nephropathy                          | 1  1  1     4  1     2  2  1  2  1  1  1  1  3  1  1  1  1     2  1  2  1|     46  1.3|
      Renal Tubule, Dilatation             | 1     2        1                    1           1                 1      |     16  1.2|
      Renal Tubule, Pigmentation           |                   3                                      1               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|             
                                           | 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Edema                                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       | 1                                                                        |             
      Clear Cell Focus                     |                                              X  X                 X      |             
      Congestion, Focal                    |                                                                          |             
      Eosinophilic Focus                   |       X        X                 X     X                       X         |             
      Hemorrhage, Focal                    |                                  3                                       |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |          1  1  1  2  1                    2        1     2     2     1   |             
      Inflammation, Chronic, Focal,        |                                                                          |             
          Suppurative                      |                                                          3               |             
      Hepatocyte, Basophilic Focus         |                                                                          |             
      Hepatocyte, Cytomegaly               |                      2  2        2           1                           |             
      Hepatocyte, Eosinophilic Focus       | 1                                                                        |             
      Hepatocyte, Karyomegaly              |                      2  2        2           1                           |             
      Hepatocyte, Necrosis, Focal          |          1     1  3                       1                              |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Focal                           |          1  1  1     1     1  1     2  1  1  1  1  1  2  1     1  1  1  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|             
                                           | 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                                              2                    2      |             
      Hepatocyte, Centrilobular, Necrosis  |                            3                                             |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      | 2     2                       2     2  3     3     2           2  2      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +                 +        +     +        +              +        +|             
      Angiectasis                          |                                                                2         |             
      Artery, Inflammation, Chronic, Focal |                                                                          |             
      Fat, Necrosis                        |       3                                3        1              2        3|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         1|             
      Inflammation, Focal                  |                                                                         2|             
      Epithelium, Hyperplasia              | 2                                                                       2|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  |                   +                                                      |             
      Epithelium, Hyperplasia, Focal       |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +                             +  +  +  +           +  +  +        +   |             
      Malformation                         |                                        1                             3   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |    2                             3  2     3           3  3  3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                      1              2                                    |             
      Artery, Inflammation, Chronic        |          1                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|             
                                           | 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                    3                     |             
      Cyst                                 |                                                             2            |             
      Cytoplasmic Alteration, Focal        |                1                                   1  1                  |             
      Capsule, Hyperplasia, Focal          |                      2                 2              3                 2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                2                                2           2            |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          | 3     1              2                                      1     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Pelvic, Hemorrhage                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       3  3  3        3                 3  3           3  3               |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|             
                                           | 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3           3        2                 2        3  2  2           3      |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +  +                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              3                           |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2        3        3     3           2                          3|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  I  +  +  +  M  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                         2|             
      Subcutaneous Tissue, Lip,            |                                                                          |             
          Hyperplasia, Lymphoid            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|             
                                           | 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Hyperostosis, Focal        | 3  3  3  3     2        3     3  3  3  3  3  3  3  3  3  3  3  2  3  3   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |       2           1                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Sinus, Foreign Body                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                                              2         |             
      Infarct                              |                                                                          |             
      Metaplasia, Focal, Osseous           |                                              1                          1|             
      Nephropathy                          | 2  1  1  2  2  2  2  2  3  1     2  2  1  1  1  1  1  1  1  3  2  1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|             
                                           | 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Glomerulus, Glomerulosclerosis       |                                                                          |             
      Pelvis, Dilatation                   |                                                             2            |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                      3  3                                                |             
      Renal Tubule, Dilatation             | 1        1     1     1           1     1           1  1  1  2        1   |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|            |
                                           | 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Diverticulum                         | X                                                                        |      1     |
      Edema                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                         1                                                |      1  1.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                        3                                 |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
      Clear Cell Focus                     |                   X                                               X      |      5     |
      Congestion, Focal                    |                2              3     2                                    |      3  2.3|
      Eosinophilic Focus                   |                                        X                                 |      6     |
      Hemorrhage, Focal                    |                2                                                         |      2  2.5|
      Infarct                              |                                                    4        3            |      2  3.5|
      Infiltration Cellular, Mixed Cell    |       1        2        1  1  2  1  1  1  1     1     1  1  2  1     1   |     25  1.3|
      Inflammation, Chronic, Focal,        |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Hepatocyte, Basophilic Focus         |                                  1                                       |      1  1.0|
      Hepatocyte, Cytomegaly               |                                                                          |      4  1.8|
      Hepatocyte, Eosinophilic Focus       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|            |
                                           | 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Karyomegaly              |                                                                          |      4  1.8|
      Hepatocyte, Necrosis, Focal          |       1        1                    2  1                       1         |      9  1.3|
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
           Focal                           | 1           2     1           1        2     2  2        1  1  1  1     1|     30  1.2|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |             2  2     2           1                    1                  |      7  1.7|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      | 2                 3                 3  2                 2               |     14  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                               +     +  +                                 |  10        |
      Angiectasis                          |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic, Focal |                                     2                                    |      1  2.0|
      Fat, Necrosis                        |                               2        2                                 |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +     +                 +              +     +  +                     |  15        |
      Malformation                         |                                                    3                     |      3  2.3|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|            |
                                           | 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
           Chronic                         |    2     3                 2              3     3                        |     12  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                                             2            |      3  1.7|
      Artery, Inflammation, Chronic        |                                     3                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    | 1                                                  1              1      |      3  1.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                      2                                                   |      2  2.0|
      Cytoplasmic Alteration, Focal        |                                                 1        1           2  2|      7  1.3|
      Capsule, Hyperplasia, Focal          |    2        2                                            1               |      7  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                                                1         |      4  1.8|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                   1      |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic, Focal          |                1                          2                 1            |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              | +                                                  +                     |   2        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|            |
                                           | 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
      Pelvic, Hemorrhage                   | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |    3                 3     3     3  3  3  3           3     3  3        3|     19  3.0|
      Inflammation, Chronic                |                      3                                               4   |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |             2     3              2     2                                3|     13  2.5|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 2                        |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                        +                                 |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                3         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |       3           3                                                      |      2  3.0|
      Hyperplasia, Plasma Cell             |    3                    3                                                |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|            |
                                           | 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     |                            2  3  3              2  3  2     3  3     3  2|     16  2.6|
      Hyperplasia, Lymphoid                |             3                                            3               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                  1     2  2     2                        |      5  1.8|
      Hyperplasia, Lymphoid                | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Lip,            |                                                                          |            |
          Hyperplasia, Lymphoid            | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Hyperostosis, Focal        | 3  3  3     3     3        3     3     3  2     2  3  2  3  2     2     2|     36  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                     +                                    |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                2         |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|            |
                                           | 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                             3            |      1  3.0|
      Sinus, Foreign Body                  |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   1        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | 3                                      2                                 |      4  2.3|
      Infarct                              |                                              3                           |      1  3.0|
      Metaplasia, Focal, Osseous           |                2                                                         |      3  1.3|
      Nephropathy                          | 1  2  1     2  1  1  1  1  2  1  2  2  1  2  1  2  1  1  1  2  1  1  2  2|     48  1.5|
      Glomerulus, Glomerulosclerosis       |                                                             1            |      1  1.0|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  3.0|
      Renal Tubule, Dilatation             |             1     1        1                          1           1     1|     17  1.1|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|             
                                           | 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.3                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  M  I  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Edema                                |                            3                                             |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |          3                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Congestion, Focal                    |                4                                            1            |             
      Congestion                           |    3                                                                     |             
      Eosinophilic Focus                   |          X  X                                                            |             
      Hemorrhage, Focal                    |                                                                          |             
      Infarct                              |                      4                          4                        |             
      Infiltration Cellular, Mixed Cell    |          1           1  2     2                    1                    1|             
      Karyomegaly                          |                                        1                                 |             
      Bile Duct, Hyperplasia               |                                                                1         |             
      Hepatocyte, Cytomegaly               |                      2     3     2     1        1              1        1|             
      Hepatocyte, Eosinophilic Focus       |       X                                                                  |             
      Hepatocyte, Karyomegaly              |                      2     3     2              1              1        1|             
      Hepatocyte, Mixed Cell Focus         |                                                                          |             
      Hepatocyte, Necrosis, Focal          | 2                             2                                          |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Focal                           | 1  1  1     1  1  1     1     1  2        1  1        1     2  1  1     1|             
      Hepatocyte, Vacuolization            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|             
                                           | 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.3                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
          Cytoplasmic, Focal               |                                                                   2      |             
      Hepatocyte, Periportal,              |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
      Hepatocyte, Centrilobular, Necrosis  |                            4                                             |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |       3     2                       2        2     3                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +        +              +        +                 +               |             
      Inflammation, Chronic                |                                                          2               |             
      Fat, Necrosis                        |       3        3                       3                 3               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Focal                  |                            3                                   2         |             
      Ulcer                                |                            3                                             |             
      Epithelium, Hyperplasia              |                            3                                   2         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic, Focal  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +                    +     +  +           +        +           +|             
      Malformation                         |          3                          2  2                                 |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |    3                          3        3           2        3           3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    | 1                          1                                             |             
      Inflammation, Chronic, Focal         |                                                                         1|             
      Artery, Inflammation, Chronic        |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|             
                                           | 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.3                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                        3                                 |             
      Cytoplasmic Alteration, Focal        |                   2  2                       2           2               |             
      Hyperplasia, Focal                   |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
      Capsule, Hyperplasia, Focal          |       2                                1  2                 2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                          2               |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                   1                                                      |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |       1  2           2     2                             2              2|             
      Follicle, Cyst                       |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 3        3     3  3  3  3  3        3                 3     3           3|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|             
                                           | 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.3                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic                |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          2     2                 3           3           3               |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                                            +         |             
      Bronchial, Hyperplasia, Plasma Cell  |                                                                3         |             
      Inguinal, Inflammation, Chronic,     |                                                                          |             
           Focal                           |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Hyperplasia, Lymphoid                |          3                                                               |             
      Hyperplasia, Plasma Cell             |                                                          3               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               4                                          |             
      Hemorrhage                           |                               3                                          |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Hyperplasia, Plasma Cell             |                                  3                    3                  |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                  3                                       |             
      Inflammation, Focal, Suppurative     |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3  2                 3     2                 2     2  3              2|             
      Hyperplasia, Lymphoid                |                   X                                               3      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | I  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        3                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|             
                                           | 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.3                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Hyperostosis, Focal        | 3              3  3     3     3  3  3  3              3  1  3     3  3  3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |          +                                                               |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Hyperplasia, Histiocytic             |                                                                3         |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               3                                          |             
      Sinus, Foreign Body                  |                                           3                              |             
      Sinus, Inflammation, Chronic,        |                                                                          |             
          Suppurative                      |                                           3                              |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|             
                                           | 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.3                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +        +                    +                          +  +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Congestion                           |                2        3     3     2                 2                  |             
      Cyst                                 |       2  2                                                           2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Nephropathy                          | 3  2  2  2  1  1  1  2  1  3     1  1  2  2  2  1  2  1  1  2  1  2  2  1|             
      Artery, Inflammation, Chronic        |                         1                                                |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                            3                                             |             
      Renal Tubule, Dilatation             |    1  2           1  2              1  2  2  1        1  1        1      |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                   3      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | M  +  M  +  +  +  +  +  A  +  +  M  +  A  M  +  M  +  +  +  M  +  +  +  +|  36        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Edema                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Focal                  |                                                       3                  |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                X  X                                X                    X|      4     |
      Congestion, Focal                    |                                                                          |      2  2.5|
      Congestion                           |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hemorrhage, Focal                    |                         3                                                |      1  3.0|
      Infarct                              |                                        4                                 |      3  4.0|
      Infiltration Cellular, Mixed Cell    | 2           1                    1              2     1     1  2     1   |     14  1.4|
      Karyomegaly                          |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
      Hepatocyte, Cytomegaly               | 2                       3  1     1  1           3        1        2     2|     16  1.7|
      Hepatocyte, Eosinophilic Focus       |                                                                          |      1     |
      Hepatocyte, Karyomegaly              | 2                       3  1     1  1           3        1        2     2|     15  1.7|
      Hepatocyte, Mixed Cell Focus         |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Necrosis, Focal          |                                                 3     1        1         |      5  1.8|
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
           Focal                           | 1  1     1     1  1  2                    2  1     1  1  2  1  1     1  2|     31  1.2|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                            2                             1               |      3  1.7|
      Hepatocyte, Periportal,              |                                                                          |            |
          Vacuolization Cytoplasmic        |             2                                                            |      1  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                         3              3                                 |      3  3.3|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |          2     3                                         1               |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                +              +              +  +                        |   9        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis                        |                2              2              3  3                        |      8  2.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                      2   |      1  2.0|
      Inflammation, Focal                  |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Glands, Degeneration, Cystic, Focal  |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +  +        +  +           +  +  +  +        +     +            |  18        |
      Malformation                         |          2                                2  2        3     2            |      8  2.3|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |             2        3  3           3  2     3                           |     12  2.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                           1                              |      3  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                     1                                    |      1  1.0|
      Angiectasis                          |                                              2                           |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |       2        2                                         1           1   |      8  1.8|
      Hyperplasia, Focal                   |                                                    3                     |      1  3.0|
      Capsule, Fibrosis, Focal             |                                        3                                 |      1  3.0|
      Capsule, Hyperplasia, Focal          |                                              2              1            |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                 1                        |      2  1.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |       1           2                                                      |      2  1.5|
      Pars Intermedia, Cyst                |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic, Focal          | 1                             2        2        1                 2  2   |     12  1.8|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |          3              3  3  3                                      3   |     16  3.0|
      Inflammation, Chronic                |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                      2   |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |       3     2                                2                           |      8  2.5|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +           +                                                   |   4        |
      Bronchial, Hyperplasia, Plasma Cell  |                                                                          |      1  3.0|
      Inguinal, Inflammation, Chronic,     |                                                                          |            |
           Focal                           |          2                                                               |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Plasma Cell             |                               3                             3            |      4  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Inflammation, Focal, Suppurative     |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  2     2              3     2  3     4        4     1        3         |     19  2.6|
      Hyperplasia, Lymphoid                |                                  3                                       |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |       2                                1                    2            |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Edema           |                                        2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Hyperostosis, Focal        | 3  3  3  1  3  3  2  3  2  3  3  3  3  3     3  3  2  3  3  2     3  2  2|     38  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |          2                                                               |      1  2.0|
      Pigmentation, Focal                  |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                     M                                    |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Larynx                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                      3                                         3  3      |      4  3.0|
      Infiltration Cellular, Mixed Cell    |                                                          2               |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    2                                2                                    |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Sinus, Foreign Body                  |                                                                          |      1  3.0|
      Sinus, Inflammation, Chronic,        |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                   +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                      3   |      1  3.0|
      Congestion                           |                                                                          |      5  2.4|
      Cyst                                 |       2     1                                                     2      |      6  1.8|
      Hyperplasia, Lymphoid                |                                                 2                        |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                      3   |      1  3.0|
      Nephropathy                          |    2  1  1  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  3  1  3  3  2|     48  1.8|
      Artery, Inflammation, Chronic        |                      2                                                   |      2  1.5|
      Pelvis, Dilatation                   |                                           2                              |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3|            |
                                           | 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.3                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |       1  1  1  1           1              1  1     1     2  2  1  2     2|     24  1.3|
      Renal Tubule, Pigmentation           | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  M  +  +  +  A  M  +  A  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                      2            |             
      Clear Cell Focus                     |                                     X                                    |             
      Congestion, Focal                    |                3                    2                                2   |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
      Hemorrhage, Focal                    |                   3              2        2  3                           |             
      Infiltration Cellular, Mixed Cell    |          1     2  3              2                             1     1  2|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Focal, Lipocyte          |             2                                                            |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                   2              1                                       |             
      Endothelial Cell, Hyperplasia, Focal |                      2                                                   |             
      Endothelial Cell, Hyperplasia        |                                  2                                       |             
      Hepatocyte, Cytomegaly               | 1     1  1     3  3  1  2     2  3     2  2  2  1  3  1     2     1     1|             
      Hepatocyte, Karyomegaly              | 1     1  1     4  3  1  2     2  3     2  2  2  1  3  1     2     1     1|             
      Hepatocyte, Necrosis, Focal          |    1                             2                                       |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Focal                           | 1  2  1  1                       1  1        1        1  1  1  1     1   |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                            2                          1                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Centrilobular, Necrosis  |                   3     3                 4        3                     |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |    2                                                                     |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                              2                           |             
      Sinusoid, Dilatation, Diffuse        |                4                                                         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +              +     +           +           +        +|             
      Artery, Inflammation, Chronic, Focal |                                                                2         |             
      Fat, Necrosis                        |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Focal                  |                                           2                              |             
      Glands, Degeneration, Cystic, Focal  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                                                1         |             
      Mineralization, Focal                |                                                    2                     |             
      Artery, Inflammation, Chronic        |                                                                2  2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   2                                                      |             
      Cytoplasmic Alteration, Focal        | 2                    2     2                    2           2  2         |             
      Cytoplasmic Alteration               |                                                                         4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hypertrophy                          |                                                 2                        |             
      Bilateral, Capsule, Fibrosis         |                                        4                                 |             
      Capsule, Hyperplasia, Focal          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                  2                                       |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          | 1              2                 2                 2        2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 3     3  3        3                 3  3  3     3     3  3           3  3|             
      Inflammation, Chronic                |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Dilatation                           |                               2                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                                +                 +              +|             
      Mediastinal, Hyperplasia, Lymphoid   |       3                                                                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                          3               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |             3                    3                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3                                                  3               |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2        2     3  4     3  3     3        3        3                     |             
      Hyperplasia, Lymphoid                |       3                             2                    3               |             
      Artery, Inflammation, Chronic, Focal |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  M  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                  2                                       |             
      Subcutaneous Tissue, Edema           |                2                                   2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
      Vertebra, Hyperostosis, Focal        |       3  3                          3  3              3     3     3     2|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                         2                                                |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                         3                    2     2                     |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  2                 2                    2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |             +                    +                                      +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Cyst                                 | 2                          1                          1     2            |             
      Metaplasia, Focal, Osseous           |    2                             2                          1  1     2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Nephropathy                          | 2  2  2  3  2  4  2  2  2  2  2  2  1  2  2  2  2  2  3  2  3  2  2  2  2|             
      Glomerulus, Glomerulosclerosis       |    1        1  4  2  2  2  2  2  2  2  2  2  1  2  2  3  1  1  1  2  1   |             
      Papilla, Necrosis                    |                3                                                         |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Dilatation             | 1        1        2  2        1  2  2        2     1  2     2     1      |             
      Renal Tubule, Necrosis, Focal        |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3|            |
                                           | 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  M  +  +|  41        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2        3  3        2                                                |      6  2.3|
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion, Focal                    |                                  3                                       |      4  2.5|
      Eosinophilic Focus                   |                               X                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                       3                  |      2  3.0|
      Hemorrhage, Focal                    |                2                                                  2      |      6  2.3|
      Infiltration Cellular, Mixed Cell    |    2        2        1  2                       2           1        1   |     14  1.6|
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Metaplasia, Focal, Lipocyte          |                                                                          |      1  2.0|
      Thrombosis                           |                                              3                           |      1  3.0|
      Bile Duct, Hyperplasia               |             2                                                            |      3  1.7|
      Endothelial Cell, Hyperplasia, Focal |    1                                                                     |      2  1.5|
      Endothelial Cell, Hyperplasia        |                                                                          |      1  2.0|
      Hepatocyte, Cytomegaly               | 1  2  1  1  3     1  2  2     2     1  2           1  3        1        2|     33  1.7|
      Hepatocyte, Karyomegaly              | 1  2  1  1  3     1  2  2     2     1  2           1  3        1        2|     33  1.8|
      Hepatocyte, Necrosis, Focal          |                3                    2                          3  2      |      6  2.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3|            |
                                           | 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
           Focal                           |    1  1  1     1  1  1     1     1  1        1  1  1     1  1     1      |     27  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               | 2                                               1           1            |      5  1.4|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      4  3.3|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  2.0|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                            3                                             |      2  2.5|
      Sinusoid, Dilatation, Diffuse        |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                 +  +  +                 +  +     +        +|  14        |
      Artery, Inflammation, Chronic, Focal |                                                          1               |      2  1.5|
      Fat, Necrosis                        |             2                    3                                       |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Glands, Degeneration, Cystic, Focal  |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                  +                  |   4        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         | 3  3                                                  3                  |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                           1                          1   |      3  1.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3|            |
                                           | 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Artery, Inflammation, Chronic        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |             2  3                    1        3  1                 1      |     12  1.9|
      Cytoplasmic Alteration               |                                                          3               |      2  3.5|
      Hemorrhage                           |                                                                4         |      1  4.0|
      Hypertrophy                          | 2                                                                        |      2  2.0|
      Bilateral, Capsule, Fibrosis         |                                                                          |      1  4.0|
      Capsule, Hyperplasia, Focal          | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Cyst                                 |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  I|  46        |
      Pars Distalis, Cyst                  |                1                                                         |      2  1.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic, Focal          |                   1           2                                          |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3|            |
                                           | 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |             3           3           3     3  3  3        3           3  3|     21  3.0|
      Inflammation, Chronic                |                                     3                                    |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                               2                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                               +                                +        +|   7        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Hyperplasia, Plasma Cell             |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3     3     3     2     2           3  2     2     3  3        2         |     20  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3|            |
                                           | 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Artery, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  43        |
      Cyst                                 |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |             2                       2                 2                  |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Hyperostosis, Focal        | 2  3     3     3  3  3     3  3     3  2  3     3        2  3     2     3|     24  2.8|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                               +                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  3                 4                     |      2  3.5|
      Hemorrhage                           |                      2     1  2                          3     2         |      8  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3|            |
                                           | 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hyperplasia, Focal, Histiocytic      |    2                                                                     |      1  2.0|
      Hyperplasia, Histiocytic             |                                                       1                  |      1  1.0|
      Metaplasia, Focal, Osseous           |                                                    1                     |      1  1.0|
      Pigmentation, Focal                  |    2                                                  1                  |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |          2                             2              1                  |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |    +           +              +     +                 +                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       3                             2                                    |      3  2.3|
      Cyst                                 |    1           2                                                  2      |      7  1.6|
      Metaplasia, Focal, Osseous           |                1        1     2                       1     1            |     10  1.4|
      Nephropathy                          | 2  2  2  2  2  2  3  2  2  2  2  2  3  2  2  2  2  2  2  2  2  3  2  2  2|     50  2.1|
      Glomerulus, Glomerulosclerosis       | 1  2  2  1  3  2  3  2  1  2  2     2  1  1     2     1  2     3  1  1  1|     42  1.8|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                       3                  |      1  3.0|
      Renal Tubule, Dilatation             | 1  1     1  2  2     2  2  1  2        2  1  2  1     1  2  1        1   |     29  1.5|
      Renal Tubule, Necrosis, Focal        |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|             
                                           | 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  A  +  +  +  A  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A|             
      Edema                                |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Fibrosis, Focal                      |    3     2                                      2                        |             
      Hemorrhage, Focal                    |    3  3  3        3     3              3           2  2     3           3|             
      Infiltration Cellular, Mixed Cell    |    3  2  3     1     3  3           3  3  1        1  2  2  3  2  2  3  3|             
      Thrombosis                           |    3  3                 3                                            3   |             
      Bile Duct, Hyperplasia               |          2        3                                                      |             
      Endothelial Cell, Hyperplasia        |                                                 2                        |             
      Hepatocyte, Cytomegaly               | 1  3  2  3  3  3  3  3  3  1  1  2  2  3  2  2        2  4  3  2  2  3  3|             
      Hepatocyte, Karyomegaly              | 1  3  2  3  3  3  3  3  3  1  1  2  2  3  2  2        2  4  3  2  2  3  3|             
      Hepatocyte, Necrosis, Focal          |    3              3  3  3                          1  2  2     2        3|             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                                                    1                     |             
      Hepatocyte, Periportal,              |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
      Hepatocyte, Centrilobular, Necrosis  |       3                       4        3                    3     2  3   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                        3                    3            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|             
                                           | 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +              +  +                             +         |             
      Artery, Inflammation, Chronic, Focal |                                                                          |             
      Fat, Necrosis                        |                                                                2         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                           +        +  +  +               |             
      Malformation                         |                                           2           2                  |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                           3        3     1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |             1                    1                                       |             
      Mineralization, Focal                |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        | 2  2     2                 2  1                    2  1  1               |             
      Fibrosis                             |                                     2                                    |             
      Inflammation, Chronic, Focal         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|             
                                           | 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                            1                                             |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |    2        1                             2        2  1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       3     3        3  3  3        3           2        3     3         |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                 4                        |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|             
                                           | 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node                              |                                  +                       +               |             
      Bronchial, Hyperplasia, Lymphoid     |                                                          2               |             
      Iliac, Hemorrhage                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          3               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             3                                                            |             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  3  3  3  3  3  3  2     2  3        3              2  2        3  3|             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Cyst                                 |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Subcutaneous Tissue, Edema           |    2              2  1        1  3  1  3           1        3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Hyperostosis, Focal        | 3        3  3     3     3           3  2  3  3  2  3  2  3     2     3   |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|             
                                           | 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2            |             
      Hemorrhage                           |                   1                                                      |             
      Infiltration Cellular, Mixed Cell    |    2     2                                                  2            |             
      Thrombosis                           |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                          1               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |             +                                      +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                           2                          2   |             
      Cyst, Multiple                       |                   2                                                      |             
      Metaplasia, Focal, Osseous           |                   1                                   1                  |             
      Nephropathy                          | 2  3  3  3  4  3  3  2  2  2  3  2  1  3  3  2  3  3  3  2  3  2  3  4  3|             
      Artery, Inflammation, Chronic        |             2                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|             
                                           | 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
      Glomerulus, Glomerulosclerosis       |    3  2  3  3     3     2        2     2  3  2  3  2  3  2  3  2  2  3  3|             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                4                 3                                       |             
      Renal Tubule, Dilatation             | 2     2     2                 2  1              2  2  2  2  1     2  2   |             
      Renal Tubule, Karyomegaly            |                         2  1        2                       1  1        2|             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6|            |
                                           | 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  M  A  A  +  +  M  +  +  +  +  +  +|  38        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  A  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  A  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  A  A  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|  39        |
      Edema                                |                                     3                                    |      1  3.0|
      Hemorrhage, Focal                    |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  A  A  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|  40        |
      Artery, Inflammation, Chronic        |                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  A  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  41        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                          2        2      |      3  2.0|
      Fibrosis, Focal                      |                                                 2  2                     |      5  2.2|
      Hemorrhage, Focal                    |       3              3  3        2     3  3  2     3  3     3     2      |     21  2.8|
      Infiltration Cellular, Mixed Cell    | 2     3           3  3  3  1           3  3  3     3     1  2  1  2     2|     32  2.3|
      Thrombosis                           |                                                                         2|      5  2.8|
      Bile Duct, Hyperplasia               |                                                 2  2  2           3      |      6  2.3|
      Endothelial Cell, Hyperplasia        |                                                                          |      1  2.0|
      Hepatocyte, Cytomegaly               | 2  3  3     2     3  3  3  2     3  2  3  2  3  3  3  3     2  2  2     3|     43  2.5|
      Hepatocyte, Karyomegaly              | 2  3  3     2     3  3  3  2     3  2  3  2  3  3  3  3     2  2  2     3|     43  2.5|
      Hepatocyte, Necrosis, Focal          | 2  3  2           3     3              3     3     3        3  2  3     3|     21  2.6|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  1.0|
      Hepatocyte, Periportal,              |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6|            |
                                           | 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Vacuolization Cytoplasmic        |                               3                                          |      1  3.0|
      Hepatocyte, Centrilobular, Necrosis  |                      3           3        3           3                  |     10  3.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        | 3                                                                        |      3  3.0|
      Serosa, Fibrosis                     |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                       +              +   |   6        |
      Artery, Inflammation, Chronic, Focal |                                                                      2   |      1  2.0|
      Fat, Necrosis                        |                                                       3                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy, Focal               |                                                                1         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Malformation                         |                                                                          |      2  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                                    2                     |      3  1.3|
      Mineralization, Focal                |                      2  1              2                                 |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6|            |
                                           | 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                1           1                                             |      2  1.0|
      Cytoplasmic Alteration, Focal        | 1        1  1                          1  1        3  2     1     1     1|     18  1.4|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Cyst                                 |                      3              3                                    |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                     2                          1         |      3  1.3|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic, Focal          |                                  2                       3               |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 | 3  3  3        3  3        3     3        3                 3           3|     19  2.9|
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6|            |
                                           | 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate, NOS                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                              +                          +|   4        |
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Iliac, Hemorrhage                    |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                   3      |      2  3.0|
      Hemorrhage                           |                                              4                           |      2  3.0|
      Hyperplasia, Lymphoid                |             4                                         2  2               |      4  2.8|
      Inflammation, Chronic                |                                                 3                        |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                2                                                         |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  3  3  2  3     3     3        3  3  3     3  3  3  4     2  3  3  2   |     33  2.8|
      Necrosis, Focal                      |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M|  43        |
      Cyst                                 |       2           2                                                      |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6|            |
                                           | 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Edema           | 3  3  1        1  2  3  3        2     3  2  1     3  1        2  1     2|     25  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Hyperostosis, Focal        |    3  3     3  3           3                    3     3  2  3  3  3     3|     27  2.8|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                 3                        |      2  2.5|
      Hemorrhage                           |                2  2                                                      |      3  1.7|
      Infiltration Cellular, Mixed Cell    | 2                                                                        |      4  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                     1                          2         |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 05161-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 09/04/01    
Route: GAVAGE                                                                                                     Time: 09:06:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6|            |
                                           | 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3.0                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                              +                           |   1        |
      Hemorrhage, Focal                    |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   2                                                      |      1  2.0|
      Cyst                                 |       2                                                           2      |      4  2.0|
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                            1                          1                  |      4  1.0|
      Nephropathy                          | 3  3  3  2  3  3  3  3  3  2  1  3  4  3  3  2  4  4  3  3  2  3  4  3  2|     50  2.8|
      Artery, Inflammation, Chronic        |                                     3                                    |      2  2.5|
      Capsule, Fibrosis                    |                                              3                           |      1  3.0|
      Glomerulus, Glomerulosclerosis       | 2  3  3  1     3  3  3  3  2     2  3  2  3     3  3  3  2  3  2  3  1  1|     41  2.5|
      Pelvis, Dilatation                   |                               2                                          |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                     2                                    |      3  3.0|
      Renal Tubule, Dilatation             | 2           2              2     2           2        1        2  3  2  2|     22  1.9|
      Renal Tubule, Karyomegaly            | 2     1     1     1     1                 2                              |     12  1.4|
      Renal Tubule, Pigmentation           |                                     1           3                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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