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TDMS Study 05162-09 Pathology Tables

NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96
Route: SKIN APPLICATION                                                                                           Time: 09:29:59

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  111-42-2

       Lock Date:  05/07/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     14            5            9           13                                     
    Moribund Sacrifice                                11           16           12           13                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           29           29           24                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Periesophageal Tissue, Necrosis                               1 (2%)                                                          
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
      Mineralization                                                                          1 (2%)                                
      Parasite Metazoan                                3 (6%)       3 (6%)       1 (2%)       1 (2%)                                
      Ulcer                                                                      1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Parasite Metazoan                                4 (8%)                    1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Intestine Large, Cecum                             (50)         (49)         (50)         (49)                                   
      Parasite Metazoan                                             1 (2%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (2%)                                 2 (4%)                                
   Intestine Small, Ileum                             (49)         (49)         (48)         (47)                                   
      Muscularis, Inflammation, Chronic Active,                                                                                     
           Focal                                                                              1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                40 (80%)     31 (62%)     20 (40%)      7 (14%)                               
      Clear Cell Focus                                              3 (6%)       2 (4%)       1 (2%)                                
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    2 (4%)                                
      Degeneration, Cystic                                                                    2 (4%)                                
      Eosinophilic Focus                               1 (2%)       5 (10%)      2 (4%)       3 (6%)                                
      Hematopoietic Cell Proliferation                 2 (4%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       2 (4%)       6 (12%)      6 (12%)      8 (16%)                               
      Mixed Cell Focus                                              3 (6%)       6 (12%)      1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Centrilobular, Degeneration                                   1 (2%)       2 (4%)                                             
      Centrilobular, Necrosis                          2 (4%)                                 1 (2%)                                
      Oval Cell, Hyperplasia                                        1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Periportal, Degeneration                                                                1 (2%)                                
      Portal, Fibrosis                                              1 (2%)                                                          
      Serosa, Fibrosis                                                           1 (2%)                                             
   Mesentery                                          (4)          (7)          (6)          (5)                                    
      Angiectasis                                                                             1 (20%)                               
      Inflammation, Chronic                                                      1 (17%)                                            
      Fat, Necrosis                                    4 (100%)     6 (86%)      4 (67%)      3 (60%)                               
   Oral Mucosa                                        (2)          (2)                       (1)                                    
      Gingival, Inflammation, Suppurative              2 (100%)     1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Acinus, Atrophy                                 13 (26%)     21 (42%)     11 (22%)     14 (28%)                               
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            2 (4%)                                
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            2 (4%)       3 (6%)       5 (10%)      6 (12%)                               
      Epithelium, Hyperplasia                          1 (2%)                    2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Mineralization                                                                          2 (4%)                                
      Ulcer                                            3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
   Tongue                                             (1)                       (1)          (1)                                    
      Inflammation, Suppurative                        1 (100%)                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                              (2)                                    
      Mineralization                                                                          2 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Atrium, Thrombosis                               1 (2%)       1 (2%)       4 (8%)       1 (2%)                                
      Myocardium, Degeneration                        36 (72%)     33 (66%)     35 (70%)     36 (72%)                               
      Myocardium, Mineralization                                                              3 (6%)                                
      Valve, Fibrosis                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     13 (26%)     13 (26%)     11 (22%)     11 (22%)                               
      Hypertrophy                                      1 (2%)       2 (4%)                    2 (4%)                                
      Necrosis, Acute                                                            1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Bilateral, Hypertrophy                                                                  1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      3 (6%)      10 (20%)      4 (8%)      10 (20%)                               
      Necrosis                                                                   1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (43)         (42)         (42)         (49)                                   
      Hyperplasia                                                                1 (2%)       1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Angiectasis                                                              1 (2%)                                
      Pars Distalis, Degeneration, Cystic              5 (10%)      3 (6%)       2 (4%)       4 (8%)                                
      Pars Distalis, Hyperplasia                       3 (6%)      11 (22%)     12 (24%)      5 (10%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             31 (62%)     33 (66%)     39 (78%)     29 (58%)                               
      Follicular Cell, Cyst                                         1 (2%)                                                          
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                   (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (49)         (47)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                      4 (8%)       4 (8%)       1 (2%)       2 (4%)                                
      Inflammation, Suppurative                        3 (6%)       4 (8%)       1 (2%)       1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             4 (8%)       4 (8%)       5 (10%)      8 (16%)                               
      Necrosis                                                      1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Prolapse                                                      1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                 1 (2%)       1 (2%)       1 (2%)                                             
      Epithelium, Hypertrophy                                       1 (2%)                                                          
   Vagina                                                          (2)          (1)          (1)                                    
      Infiltration Cellular, Polymorphonuclear                      2 (100%)                                                        
      Inflammation, Chronic                                                      1 (100%)                                           
      Muscularis, Hyperplasia                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       6 (12%)      4 (8%)       5 (10%)                               
      Myelofibrosis                                    1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
   Lymph Node, Mandibular                             (50)         (49)         (50)         (48)                                   
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         1 (2%)                    3 (6%)       2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       3 (6%)       4 (8%)       1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Capsule, Pigmentation, Focal, Hemosiderin                                               1 (2%)                                
      Lymphoid Follicle, Atrophy                       2 (4%)       1 (2%)                    1 (2%)                                
      Lymphoid Follicle, Hyperplasia                                1 (2%)                                                          
   Thymus                                             (49)         (49)         (47)         (48)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Epidermis, Fibrosis                                                        1 (2%)                                             
      Epidermis, Skin, Site of Application,                                                                                         
          Acanthosis                                   1 (2%)       1 (2%)       4 (8%)       6 (12%)                               
      Epidermis, Skin, Site of Application, Exudate    1 (2%)       7 (14%)      7 (14%)      7 (14%)                               
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperkeratosis                               3 (6%)      13 (26%)     23 (46%)     23 (46%)                               
      Skin, Site of Application, Ulcer                 2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       5 (10%)      2 (4%)       5 (10%)      5 (10%)                               
      Fibrosis, Focal                                                                         1 (2%)                                
      Inflammation, Granulomatous                      3 (6%)       3 (6%)       5 (10%)      9 (18%)                               
      Mineralization                                                                          2 (4%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Interstitium, Inflammation, Chronic                           2 (4%)       2 (4%)                                             
   Nose                                               (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
   Pleura                                                          (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)          (2)                                    
      Cataract                                         1 (50%)                                1 (50%)                               
      Degeneration                                     1 (50%)                                                                      
      Anterior Chamber, Inflammation, Suppurative                                1 (100%)                                           
      Retina, Atrophy                                                                         1 (50%)                               
   Harderian Gland                                                 (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Nephropathy                                     40 (80%)     47 (94%)     48 (96%)     48 (96%)                               
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Mineralization                                               1 (2%)       1 (2%)                                
      Renal Tubule, Pigmentation, Hemosiderin                       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           31           25           22                                     
    Natural Death                                      5            9            4            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           10           21           22                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                2 (4%)                    3 (6%)       3 (6%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Parasite Metazoan                                4 (8%)       2 (4%)       4 (8%)       3 (6%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Parasite Metazoan                                             1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)                    1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Ulcer                                            3 (6%)                                 1 (2%)                                
   Intestine Small, Jejunum                           (50)         (46)         (48)         (48)                                   
      Diverticulum                                     1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Muscularis, Inflammation, Chronic                                          1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                15 (30%)      5 (10%)      1 (2%)       2 (4%)                                
      Clear Cell Focus                                 1 (2%)                    3 (6%)       2 (4%)                                
      Degeneration, Cystic                             2 (4%)       2 (4%)       5 (10%)      2 (4%)                                
      Degeneration, Fatty                              6 (12%)      5 (10%)      9 (18%)      7 (14%)                               
      Eosinophilic Focus                               4 (8%)       2 (4%)       2 (4%)       2 (4%)                                
      Hepatodiaphragmatic Nodule                       6 (12%)      1 (2%)       8 (16%)      4 (8%)                                
      Mixed Cell Focus                                 1 (2%)                                 1 (2%)                                
      Necrosis                                         2 (4%)                                 1 (2%)                                
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Centrilobular, Degeneration                      3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Centrilobular, Necrosis                                       1 (2%)       1 (2%)                                             
      Midzonal, Vacuolization Cytoplasmic                                                     1 (2%)                                
      Sinusoid, Congestion                                          1 (2%)                                                          
   Mesentery                                          (7)          (4)          (8)          (3)                                    
      Hemorrhage                                       1 (14%)                                                                      
      Artery, Inflammation, Chronic                                              1 (13%)                                            
      Artery, Thrombosis                               2 (29%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    4 (57%)      3 (75%)      4 (50%)      3 (100%)                              
   Oral Mucosa                                        (7)          (2)          (2)                                                 
      Inflammation, Suppurative                        4 (57%)      1 (50%)                                                         
      Gingival, Inflammation, Suppurative              2 (29%)                   2 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                 23 (46%)     18 (36%)     26 (52%)     24 (48%)                               
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)                                                          
      Artery, Thrombosis                               1 (2%)                    1 (2%)                                             
      Duct, Atrophy                                                              1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            4 (8%)       1 (2%)       2 (4%)       2 (4%)                                
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Ulcer                                            7 (14%)      8 (16%)      9 (18%)     10 (20%)                               
      Epithelium, Hyperplasia                                       1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   4 (8%)       3 (6%)       2 (4%)       1 (2%)                                
      Ulcer                                            7 (14%)      4 (8%)       5 (10%)      4 (8%)                                
   Tongue                                                                       (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (4)          (3)                       (1)                                    
      Mineralization                                   4 (100%)     3 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Degeneration, Fatty                                                                     1 (2%)                                
      Atrium, Thrombosis                               2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Myocardium, Degeneration                        41 (82%)     41 (82%)     44 (88%)     45 (90%)                               
      Myocardium, Mineralization                       1 (2%)       1 (2%)       1 (2%)                                             
      Valve, Degeneration                                           1 (2%)                                                          
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia                                     16 (32%)     15 (30%)     15 (30%)     12 (24%)                               
      Hypertrophy                                                                2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Degeneration, Cystic                                          2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                     11 (22%)      9 (18%)     15 (30%)      8 (16%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       4 (8%)       5 (10%)      4 (8%)                                
   Parathyroid Gland                                  (46)         (49)         (48)         (47)                                   
      Hyperplasia                                      2 (4%)       9 (18%)      1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                             1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Pars Distalis, Degeneration, Cystic              2 (4%)                    2 (4%)       2 (4%)                                
      Pars Distalis, Hyperplasia                       4 (8%)       8 (16%)      7 (14%)      8 (16%)                               
      Pars Distalis, Hypoplasia                                     1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Cyst                                             1 (2%)                                 1 (2%)                                
      Bilateral, Follicular Cell, Cyst                                           1 (2%)                                             
      C-Cell, Hyperplasia                             33 (66%)     37 (74%)     42 (84%)     33 (67%)                               
      Follicular Cell, Cyst                                         2 (4%)                    2 (4%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Arteriole, Inflammation, Chronic                 1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                   3 (6%)       1 (2%)       2 (4%)                                
      Inflammation, Granulomatous                      2 (4%)                    5 (10%)      3 (6%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Inflammation, Suppurative                        2 (4%)       6 (12%)      3 (6%)       4 (8%)                                
      Necrosis                                         1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 2 (4%)                                
      Fibrosis                                                                   1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Germinal Epithelium, Atrophy                    16 (32%)     10 (20%)     11 (22%)      9 (18%)                               
      Interstitial Cell, Hyperplasia                   2 (4%)       1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                     10 (20%)      4 (8%)       7 (14%)      9 (18%)                               
   Lymph Node                                         (4)          (4)          (5)          (2)                                    
      Mediastinal, Ectasia                                                                    1 (50%)                               
      Mediastinal, Hematopoietic Cell Proliferation    1 (25%)                                                                      
      Renal, Infiltration Cellular, Plasma Cell                                  1 (20%)                                            
   Lymph Node, Mandibular                             (49)         (48)         (50)         (49)                                   
      Atrophy                                          1 (2%)                                                                       
      Erythrophagocytosis                                           1 (2%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                                                                       
      Ectasia                                          2 (4%)                    1 (2%)       1 (2%)                                
      Erythrophagocytosis                                           1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)       1 (2%)       3 (6%)                                             
      Fibrosis                                         7 (14%)     10 (20%)      9 (18%)      2 (4%)                                
      Hematopoietic Cell Proliferation                              2 (4%)       3 (6%)       1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                                     3 (6%)       1 (2%)       1 (2%)                                
      Lymphoid Follicle, Atrophy                       1 (2%)       2 (4%)                                                          
      Lymphoid Follicle, Necrosis                      1 (2%)                                                                       
   Thymus                                             (47)         (48)         (48)         (47)                                   
      Atrophy                                          1 (2%)                                                                       
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (48)         (45)         (42)                                   
      Hyperplasia, Cystic                              5 (11%)      5 (10%)      5 (11%)      1 (2%)                                
      Duct, Dilatation                                                           1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Dermis, Skin, Site of Application, Fibrosis                                1 (2%)       1 (2%)                                
      Epidermis, Skin, Site of Application,                                                                                         
          Acanthosis                                                2 (4%)       4 (8%)      10 (20%)                               
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                                        2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Skin, Site of Application, Erosion                              1 (2%)                                             
      Epidermis, Skin, Site of Application, Exudate                 3 (6%)       2 (4%)       7 (14%)                               
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperkeratosis                                            3 (6%)       5 (10%)     11 (22%)                               
      Skin, Site of Application, Ulcer                                                        2 (4%)                                
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Suppurative                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Fibrous Osteodystrophy                           3 (6%)       4 (8%)       4 (8%)                                             
      Vertebra, Hyperostosis                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Degeneration                                                                            1 (2%)                                
      Choroid Plexus, Thrombosis                       1 (2%)                                                                       
      Medulla, Demyelination, Focal                                              1 (2%)                                             
      Medulla, Necrosis, Focal                                                   2 (4%)                                             
   Spinal Cord                                        (2)                       (1)          (1)                                    
      Gliosis                                                                                 1 (100%)                              
      Neuron, Degeneration                             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)       3 (6%)                                                          
      Hemorrhage, Focal                                             1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Granulomatous                      5 (10%)                   2 (4%)       2 (4%)                                
      Mineralization                                   3 (6%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                              5 (10%)      2 (4%)       2 (4%)                                
      Bronchus, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                                1 (2%)                                
      Bronchus, Infiltration Cellular,                                                                                              
          Polymorphonuclear                                                                   1 (2%)                                
      Interstitium, Inflammation, Chronic                           3 (6%)       1 (2%)       2 (4%)                                
   Nose                                               (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        2 (4%)       5 (10%)      4 (8%)       9 (18%)                               
      Glands, Hyperplasia                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05162-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:29:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)          (2)          (2)                                    
      Cataract                                                      1 (50%)      2 (100%)                                           
      Degeneration                                                  1 (50%)                                                         
      Lens, Cataract                                                                          2 (100%)                              
   Harderian Gland                                    (3)                                                                           
      Inflammation, Acute                              1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                                           1 (2%)                                
      Cyst                                             3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          2 (4%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Nephropathy                                     48 (96%)     48 (96%)     50 (100%)    48 (96%)                               
   Urinary Bladder                                    (48)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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