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TDMS Study 05162-09 Pathology Tables

NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96
Route: SKIN APPLICATION                                                                                           Time: 10:20:29

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  111-42-2

       Lock Date:  05/07/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1

NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 7| 0| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 5| 9| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3|             
                                           | 8| 0| 0| 9| 1| 0| 0| 0| 7| 1| 1| 1| 9| 8| 7| 0| 1| 0| 1| 6| 0| 9| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                 X           X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X  X     X  X  X  X  X|             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                       X                  |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Centrilobular, Necrosis              |                         3                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                    +   |             
      Fat, Necrosis                        |                                                 2                    3   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                     +                                   +|             
      Gingival, Inflammation, Suppurative  |                                     2                                   1|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |             1              1  1  2  2  1     1                       1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     3                                    |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Ulcer                                |                         4           2                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                         2                                                |             
      Myocardium, Degeneration             | 2  2        2  1  3  1  1     1  2  2  1  1  3  4  1  1     1  1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1     1     1                       2  1                           |             
      Hypertrophy                          |                                                             4            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 7| 0| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 5| 9| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3|             
                                           | 8| 0| 0| 9| 1| 0| 0| 0| 7| 1| 1| 1| 9| 8| 7| 0| 1| 0| 1| 6| 0| 9| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                     1                                    |             
      Pars Distalis, Degeneration, Cystic  |          1              1                                               3|             
      Pars Distalis, Hyperplasia           |                   2  2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     2  2  3     3     2                       3  4  2        2  4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2                                                      |             
      Hyperplasia                          |    3                       3                 2                           |             
      Inflammation, Suppurative            |                            3                 4                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         4                                                |             
      Hyperplasia                          |                4                                                         |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         4                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         4                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 7| 0| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 5| 9| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3|             
                                           | 8| 0| 0| 9| 1| 0| 0| 0| 7| 1| 1| 1| 9| 8| 7| 0| 1| 0| 1| 6| 0| 9| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |                                                                          |             
      Skin, Site of Application, Ulcer     |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                    3         |             
      Inflammation, Granulomatous          |                            1                                             |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                   +|             
      Cataract                             |                                                                         4|             
      Degeneration                         |                                     4                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1     3     1  1  1  1  1  1  1        1  1  1  1  2  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 6| 5| 4| 6| 5| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 6| 2| 8| 3| 4| 0| 3| 5| 3| 3| 6| 0|            |
                                           | 3| 8| 2| 2| 0| 1| 1| 0| 0| 2| 0| 1| 1| 0| 2| 9| 8| 8| 6| 0| 0| 0| 1| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X        X                             X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X  X  X  X  X  X     X  X  X  X     X           X  X  X  X  X   |     40     |
      Congestion                           |       2                                                                  |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                       1                  |      2  1.5|
      Hepatodiaphragmatic Nodule           |          X                    X                                          |      2     |
      Centrilobular, Necrosis              |                                                                      3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                 +|   4        |
      Fat, Necrosis                        |                                                       4                 3|      4  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Gingival, Inflammation, Suppurative  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                       4                  |      1  4.0|
      Acinus, Atrophy                      |    2           2  4              2                             3         |     13  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |    3                                                                     |      2  3.0|
      Epithelium, Hyperplasia              |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                          2               |      1  2.0|
      Ulcer                                |                                                                      2   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   1        |
      Inflammation, Suppurative            |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Myocardium, Degeneration             | 1           1  2  2  2  1     4  1  2  1  2           3  1     1  2      |     36  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 6| 5| 4| 6| 5| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 6| 2| 8| 3| 4| 0| 3| 5| 3| 3| 6| 0|            |
                                           | 3| 8| 2| 2| 0| 1| 1| 0| 0| 2| 0| 1| 1| 0| 2| 9| 8| 8| 6| 0| 0| 0| 1| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1  1        1           2                          1     3  3           1|     13  1.5|
      Hypertrophy                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Hyperplasia                          |                                                    1     1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Pars Distalis, Degeneration, Cystic  |    3                          3                                          |      5  2.2|
      Pars Distalis, Hyperplasia           |                                           1                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2     1  1  2  3  1     2  2  3  3  3     1  2  2  1  1  2  1  3  3      |     31  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                         3|      4  2.8|
      Inflammation, Suppurative            |                                                                         3|      3  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             4     4                    3                                 |      4  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                      2   |      2  3.0|
      Myelofibrosis                        |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 6| 5| 4| 6| 5| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 6| 2| 8| 3| 4| 0| 3| 5| 3| 3| 6| 0|            |
                                           | 3| 8| 2| 2| 0| 1| 1| 0| 0| 2| 0| 1| 1| 0| 2| 9| 8| 8| 6| 0| 0| 0| 1| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                    1                     |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                      4   |      1  4.0|
      Lymphoid Follicle, Atrophy           |                                                       3              4   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                      4   |      1  4.0|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                       4                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      |                                                             2            |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |    1                                                                     |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |                      1  1                                   1            |      3  1.0|
      Skin, Site of Application, Ulcer     |                                                             2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       2                                      3              3            |      5  2.8|
      Inflammation, Granulomatous          |       1                                            1                     |      3  1.0|
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 6| 5| 4| 6| 5| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 5| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 6| 2| 8| 3| 4| 0| 3| 5| 3| 3| 6| 0|            |
                                           | 3| 8| 2| 2| 0| 1| 1| 0| 0| 2| 0| 1| 1| 0| 2| 9| 8| 8| 6| 0| 0| 0| 1| 6| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  4.0|
      Degeneration                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                            +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     4                                    |      1  4.0|
      Nephropathy                          | 1  1  1  1  1  2  1  2  2        1  2  1  1  1     2  1  1  1  1         |     40  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 0| 5| 3| 3| 4| 3| 3| 3| 9| 3| 0| 0| 3| 0| 3| 3|             
                                           | 1| 1| 0| 0| 0| 0| 9| 1| 8| 2| 5| 0| 1| 4| 1| 0| 0| 9| 0| 4| 3| 0| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Necrosis      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X     X           X        X  X  X     X  X  X  X  X  X     X  X  X|             
      Clear Cell Focus                     |                            X                    X                        |             
      Eosinophilic Focus                   |    X                                X  X        X                        |             
      Hepatodiaphragmatic Nodule           |             X                       X              X     X               |             
      Mixed Cell Focus                     |    X  X                                                  X               |             
      Necrosis                             |                                                                          |             
      Centrilobular, Degeneration          |                   2                                                      |             
      Oval Cell, Hyperplasia               |                                                                          |             
      Portal, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                    +                          +               |             
      Fat, Necrosis                        |          2                    3                          3               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                              +                          +|             
      Gingival, Inflammation, Suppurative  |                                                                         2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      | 1              2     1  1        1  1  2     1        1  1  1        2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                            4                                      2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                   4                                                      |             
      Myocardium, Degeneration             | 1  3  3     2        2           2           1  1  1  2  1  1  1     2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           3     4                       2  1     1  4  1      |             
      Hypertrophy                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 0| 5| 3| 3| 4| 3| 3| 3| 9| 3| 0| 0| 3| 0| 3| 3|             
                                           | 1| 1| 0| 0| 0| 0| 9| 1| 8| 2| 5| 0| 1| 4| 1| 0| 0| 9| 0| 4| 3| 0| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                   2     2  2              1           1        1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Degeneration, Cystic  |                   2        1                                             |             
      Pars Distalis, Hyperplasia           |       3  1                                                     1         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  2  4        3  2  2  2     3  3     4     3        3  4  3  3  3  4|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             3     2      |             
      Inflammation, Suppurative            |             3                                            3               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                4                                      4     4            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
      Epithelium, Hypertrophy              |                            2                                             |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             4           3                             3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                      +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3                                   3                  |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 8| 3| 3| 0| 5| 3| 3| 4| 3| 3| 3| 9| 3| 0| 0| 3| 0| 3| 3|             
                                           | 1| 1| 0| 0| 0| 0| 9| 1| 8| 2| 5| 0| 1| 4| 1| 0| 0| 9| 0| 4| 3| 0| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |          1  1              1     1        1  1                           |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |          1     1  1           1                                   1  1   |             
      Skin, Site of Application, Ulcer     |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Inflammation, Granulomatous          |                                                                1         |             
      Alveolar Epithelium, Hyperplasia     |    1                                                  2                  |             
      Interstitium, Inflammation, Chronic  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  1  1  1  1  1  1  1     1  1  2  1  3  1  2  2  2  1  2  2  2  1  1  1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 3| 5| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 8| 3| 3| 3| 3| 3| 2| 3| 9| 4| 3| 8| 0| 3| 3| 2| 9| 6| 2|            |
                                           | 1| 6| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 4| 1| 2| 1| 1| 9| 3| 0| 0| 3| 7| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Periesophageal Tissue, Necrosis      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X                          X                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X     X     X  X  X     X  X  X     X  X     X     X     X      |     31     |
      Clear Cell Focus                     |                                     X                                    |      3     |
      Eosinophilic Focus                   |                                                 X                        |      5     |
      Hepatodiaphragmatic Nodule           |       X        X                                                         |      6     |
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |                      2                                                   |      1  2.0|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
      Oval Cell, Hyperplasia               |                                                                      2   |      1  2.0|
      Portal, Fibrosis                     |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                 +                 +              +   |   7        |
      Fat, Necrosis                        |                   3                 4                                3   |      6  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Gingival, Inflammation, Suppurative  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                      4   |      1  4.0|
      Acinus, Atrophy                      |          1  1           1              2        1  1     2  1           1|     21  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                   2      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                         1|      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Myocardium, Degeneration             | 2     1  3  1  3  2  1  3  1  1        1        3  1  1  1  1        2  1|     33  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 3| 5| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 8| 3| 3| 3| 3| 3| 2| 3| 9| 4| 3| 8| 0| 3| 3| 2| 9| 6| 2|            |
                                           | 1| 6| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 4| 1| 2| 1| 1| 9| 3| 0| 0| 3| 7| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     2  2     2                                   4                     |     13  2.2|
      Hypertrophy                          |                                                                      3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                 1                    1                          1|     10  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             2                                                            |      1  2.0|
      Pars Distalis, Degeneration, Cystic  |                                        2                                 |      3  1.7|
      Pars Distalis, Hyperplasia           |       2              1     2     1     1                 3           1  1|     11  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 3  3           3     2  3        3     2  2  2  3  2  2  2  3        2  2|     33  2.7|
      Follicular Cell, Cyst                |                                                                   3      |      1  3.0|
      Follicular Cell, Hyperplasia         |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3           1                                                   |      4  2.3|
      Inflammation, Suppurative            |                                  2  3                                    |      4  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         4                                                |      4  4.0|
      Necrosis                             |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                      4   |      1  4.0|
      Prolapse                             |                                                                X         |      1     |
      Endometrium, Hyperplasia, Cystic     |                               2                                          |      1  2.0|
      Epithelium, Hypertrophy              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                 +   |   2        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |    3                                                                 1   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            4                          3              4   |      6  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 3| 5| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 8| 3| 3| 3| 3| 3| 2| 3| 9| 4| 3| 8| 0| 3| 3| 2| 9| 6| 2|            |
                                           | 1| 6| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 4| 1| 2| 1| 1| 9| 3| 0| 0| 3| 7| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                       +                  |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                2                                                         |      3  2.7|
      Lymphoid Follicle, Atrophy           |                                                                      4   |      1  4.0|
      Lymphoid Follicle, Hyperplasia       |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      | 1                                                                        |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                            1                                             |      7  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  | 1        1        1     1                       1     1              1   |     13  1.0|
      Skin, Site of Application, Ulcer     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |             3                                                            |      2  2.5|
      Inflammation, Granulomatous          |                      1                          1                        |      3  1.0|
      Alveolar Epithelium, Hyperplasia     |                               1                                          |      3  1.3|
      Interstitium, Inflammation, Chronic  |                                                                      1   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                      +   |   1        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 3| 5| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 8| 3| 3| 3| 3| 3| 2| 3| 9| 4| 3| 8| 0| 3| 3| 2| 9| 6| 2|            |
                                           | 1| 6| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 4| 1| 2| 1| 1| 9| 3| 0| 0| 3| 7| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    8 MG/KG                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 1  1  1  2  1  2  2  1  4  1  1  1  2  2  1  2  3  2  1  2  2     2  1   |     47  1.5|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7| 6| 6| 6| 7| 4| 7| 7| 5| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 9| 3| 9| 3| 3| 1| 3| 6| 6| 3| 5| 3| 9| 3| 9| 3| 3| 7| 3| 9| 3| 3| 3|             
                                           | 0| 0| 4| 0| 5| 0| 1| 9| 0| 5| 1| 1| 6| 4| 7| 0| 0| 1| 1| 9| 1| 2| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    16 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
      Ulcer                                |                                                                         4|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 2                        |             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X     X                       X           X  X     X     X      |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |          X                       X                                       |             
      Hepatodiaphragmatic Nodule           |                                                                   X     X|             
      Mixed Cell Focus                     |                                     X        X        X     X            |             
      Centrilobular, Degeneration          |                                           2     3                        |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +        +  +                       +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                     2        3  3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 1           1           2  1                 1     1     2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     1           4              3     4   |             
      Epithelium, Hyperplasia              |                                        3  2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |             3                                                           2|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
      Inflammation, Suppurative            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                           4     1              3         |             
      Myocardium, Degeneration             | 3  1  2  1     3  2  1        1  1  2  1  1  2  1  1  2  1  2     2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1        1                    2                 2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7| 6| 6| 6| 7| 4| 7| 7| 5| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 9| 3| 9| 3| 3| 1| 3| 6| 6| 3| 5| 3| 9| 3| 9| 3| 3| 7| 3| 9| 3| 3| 3|             
                                           | 0| 0| 4| 0| 5| 0| 1| 9| 0| 5| 1| 1| 6| 4| 7| 0| 0| 1| 1| 9| 1| 2| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    16 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis, Acute                      |                                           3                              |             
      Thrombosis                           |                                                 3                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                 2                                      2   |             
      Necrosis                             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Degeneration, Cystic  |                                              3                           |             
      Pars Distalis, Hyperplasia           |    3     3     1                 4  1     2  2  1  2        3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4  2  2           3     3     3  2  3     1  3     4  3  2  4  1     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                                   4     4                          4   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4                             3                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                                  +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2     2                       4                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7| 6| 6| 6| 7| 4| 7| 7| 5| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 9| 3| 9| 3| 3| 1| 3| 6| 6| 3| 5| 3| 9| 3| 9| 3| 3| 7| 3| 9| 3| 3| 3|             
                                           | 0| 0| 4| 0| 5| 0| 1| 9| 0| 5| 1| 1| 6| 4| 7| 0| 0| 1| 1| 9| 1| 2| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    16 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Fibrosis                  |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |          1              1        1                                       |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         | 1        1     1        1                                                |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  | 1     1  1     1  1     1        1        1              1  1  1         |             
      Skin, Site of Application, Ulcer     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2              2     2                              |             
      Inflammation, Granulomatous          |                                              1                    1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  1  2  2  2  2  2  2  3     1  2  1  1  1  2  1  1  2  2  2  2  2  4  1|             
      Renal Tubule, Hyperplasia            |             4                                                            |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 3| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 1| 3| 4| 3| 6| 2| 3| 5| 7| 9| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 7| 9| 0| 8| 0| 5| 7| 0| 1| 9| 1| 1| 1| 6| 1| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    16 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Parasite Metazoan                    |          X                                                               |      1     |
      Ulcer                                |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X        X        X           X              X     X  X  X  X  X   |     20     |
      Clear Cell Focus                     | X                       X                                                |      2     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |          X                       X     X                    X            |      6     |
      Mixed Cell Focus                     |    X                                   X                                 |      6     |
      Centrilobular, Degeneration          |                                                                          |      2  2.5|
      Serosa, Fibrosis                     |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                          +                        |   6        |
      Inflammation, Chronic                |                      1                                                   |      1  1.0|
      Fat, Necrosis                        |                                                 2                        |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
      Acinus, Atrophy                      |          2     1                                      1     2            |     11  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                 3                        |      5  3.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                      3                                                   |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 3| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 1| 3| 4| 3| 6| 2| 3| 5| 7| 9| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 7| 9| 0| 8| 0| 5| 7| 0| 1| 9| 1| 1| 1| 6| 1| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    16 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Degeneration             | 3  2  2     2  2  1  2  2        1  1  1                    2  1  1     1|     35  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  1     3     3  4     3     2                                          |     11  2.3|
      Necrosis, Acute                      |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                       2                  |      4  1.8|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  42        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Degeneration, Cystic  |                            3                                             |      2  3.0|
      Pars Distalis, Hyperplasia           | 1                                                                    4   |     12  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 4  3  3  4  2  3  2  2  3     4  2  2  4     2  1  3  3  2  3  3  4  3  3|     39  2.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                   +                                                      |   1        |
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          4                                                               |      1  4.0|
      Inflammation, Suppurative            |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             3                                                            |      5  3.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                   +                                                      |   1        |
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          4                                                               |      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 3| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 1| 3| 4| 3| 6| 2| 3| 5| 7| 9| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 7| 9| 0| 8| 0| 5| 7| 0| 1| 9| 1| 1| 1| 6| 1| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    16 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2        1                 3                                             |      3  2.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      4  2.5|
      Necrosis                             |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Fibrosis                  |       2                                                                  |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      |                                                                      1   |      4  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                                             1     1  1   |      7  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |    1     1           1  1  1  1  1  1        1  1  1        1            |     23  1.0|
      Skin, Site of Application, Ulcer     |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  2        4                              |      5  2.4|
      Inflammation, Granulomatous          |       1        1  2                                                      |      5  1.2|
      Alveolar Epithelium, Hyperplasia     |                                                             2     1      |      2  1.5|
      Interstitium, Inflammation, Chronic  |    1                                1                                    |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   1        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 7| 3| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 1| 3| 4| 3| 6| 2| 3| 5| 7| 9| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 7| 9| 0| 8| 0| 5| 7| 0| 1| 9| 1| 1| 1| 6| 1| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    16 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Suppurative                      |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 3  3  3  1  1  4  2  2  2  1  2  3  1  1     2  1  3  2  1  1  3  3  1  3|     48  1.9|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|
      Renal Tubule, Mineralization         |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 6| 7| 6| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 8| 4| 3| 6| 1| 0| 7| 3| 2| 3| 9| 3| 3| 3| 3| 5| 7| 3| 2| 3| 3|             
                                           | 0| 5| 8| 1| 6| 2| 1| 9| 5| 6| 5| 0| 9| 1| 9| 1| 1| 0| 0| 9| 2| 1| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    32 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                       X                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Muscularis, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X     X                             X        X        X     X   |             
      Clear Cell Focus                     | X                                                                        |             
      Cyst                                 |                      3                                                   |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                            X                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X  X                                            X  X      |             
      Mixed Cell Focus                     |                                                                         X|             
      Centrilobular, Necrosis              |                                                                          |             
      Periportal, Degeneration             |                                                          2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +           +           +                        |             
      Angiectasis                          |                                                 3                        |             
      Fat, Necrosis                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                        +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1                 1  1           1        1              1              1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                  4        4                 2            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 6| 7| 6| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 8| 4| 3| 6| 1| 0| 7| 3| 2| 3| 9| 3| 3| 3| 3| 5| 7| 3| 2| 3| 3|             
                                           | 0| 5| 8| 1| 6| 2| 1| 9| 5| 6| 5| 0| 9| 1| 9| 1| 1| 0| 0| 9| 2| 1| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    32 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                           2                              |             
      Myocardium, Degeneration             | 2     2  3     1  2     1  1     1  2  2     1     1  1  1     3     2   |             
      Myocardium, Mineralization           |                                                                          |             
      Valve, Fibrosis                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                       1                    3           1      |             
      Hypertrophy                          |                                                 3                        |             
      Bilateral, Hypertrophy               |                                                             3            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                       1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                             3            |             
      Pars Distalis, Degeneration, Cystic  |       1                                                                  |             
      Pars Distalis, Hyperplasia           | 1                                4                    2                 2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  3           1  3              3     3  1     3           1  3  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          4        2  4                                1                  |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Muscularis, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 6| 7| 6| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 8| 4| 3| 6| 1| 0| 7| 3| 2| 3| 9| 3| 3| 3| 3| 5| 7| 3| 2| 3| 3|             
                                           | 0| 5| 8| 1| 6| 2| 1| 9| 5| 6| 5| 0| 9| 1| 9| 1| 1| 0| 0| 9| 2| 1| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    32 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                       3                    3                  |             
      Necrosis                             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                 +                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Pigmentation, Focal,        |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |                1                    1              2           1         |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |       1                                                        1     1  1|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  | 1  1  1  1        1     1     1  1        1     1     1     1  1  1     1|             
      Skin, Site of Application, Ulcer     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                   +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Granulomatous          |          2     1        1     1              1                    1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 6| 7| 6| 5| 7| 6| 7| 6| 7| 6| 7| 7| 4| 7| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 8| 4| 3| 6| 1| 0| 7| 3| 2| 3| 9| 3| 3| 3| 3| 5| 7| 3| 2| 3| 3|             
                                           | 0| 5| 8| 1| 6| 2| 1| 9| 5| 6| 5| 0| 9| 1| 9| 1| 1| 0| 0| 9| 2| 1| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    32 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 4  2     4  2  3  2  3  1  2  2  4  3  2  3  4  4  2  2  3  3  4  3  4  3|             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 0| 5| 3| 3| 3| 0| 6| 6| 3| 8| 9| 8| 3| 3| 3| 3| 0| 1| 3| 4| 3|            |
                                           | 5| 0| 1| 1| 0| 6| 0| 1| 0| 9| 5| 8| 0| 9| 0| 4| 1| 0| 0| 1| 3| 7| 1| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    32 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                  3                                       |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                  2                                       |      1  2.0|
      Ulcer                                |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Muscularis, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                   X                                                      |      7     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cyst                                 |                                  4                                       |      2  3.5|
      Degeneration, Cystic                 |                                              1                          1|      2  1.0|
      Eosinophilic Focus                   |    X                                                                    X|      3     |
      Hematopoietic Cell Proliferation     |                                                          2               |      1  2.0|
      Hepatodiaphragmatic Nodule           |                      X  X           X                                   1|      8  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Centrilobular, Necrosis              |                                                          3               |      1  3.0|
      Periportal, Degeneration             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                +                           |   5        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fat, Necrosis                        |             3                                2                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       1        1  1           1              1  1                 1      |     14  1.0|
      Artery, Inflammation, Chronic Active |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                              3                 3         |      2  3.0|
      Mineralization                       |                                  4                                       |      1  4.0|
      Ulcer                                |    3                    4              4                                 |      6  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 0| 5| 3| 3| 3| 0| 6| 6| 3| 8| 9| 8| 3| 3| 3| 3| 0| 1| 3| 4| 3|            |
                                           | 5| 0| 1| 1| 0| 6| 0| 1| 0| 9| 5| 8| 0| 9| 0| 4| 1| 0| 0| 1| 3| 7| 1| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    32 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                  4                          3            |      2  3.5|
      Ulcer                                |                                                          2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                         +                                                |   1        |
      Inflammation, Suppurative            |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                  +                          +            |   2        |
      Mineralization                       |                                  4                          2            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Myocardium, Degeneration             |    1        1  2  2  2  1  2  2     1  1  2     2  3  3  2  3  2  1  1  1|     36  1.7|
      Myocardium, Mineralization           |                               1  4                          2            |      3  2.3|
      Valve, Fibrosis                      |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                    3                 1  2     1     1        1|     11  1.5|
      Hypertrophy                          |                2                                                         |      2  2.5|
      Bilateral, Hypertrophy               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1     1     1        2                                1  1  2  1      |     10  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Degeneration, Cystic  |       2                                                  2  2            |      4  1.8|
      Pars Distalis, Hyperplasia           |                                        2                                 |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       3  1  2  1  3     2           3  1     1  3  3     2  2  2  2     3|     29  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 0| 5| 3| 3| 3| 0| 6| 6| 3| 8| 9| 8| 3| 3| 3| 3| 0| 1| 3| 4| 3|            |
                                           | 5| 0| 1| 1| 0| 6| 0| 1| 0| 9| 5| 8| 0| 9| 0| 4| 1| 0| 0| 1| 3| 7| 1| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    32 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                4                                                         |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    3  4                                   4                    4         |      8  3.3|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
      Muscularis, Hyperplasia              |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3     3                                                         |      5  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                   +      |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |       2                             2                                    |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                          4               |      1  4.0|
      Capsule, Pigmentation, Focal,        |                                                                          |            |
          Hemosiderin                      |                                        1                                 |      1  1.0|
      Lymphoid Follicle, Atrophy           |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      |             1                    1                                       |      6  1.2|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |          1  1     1                                                      |      7  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |    1  1  1                             2     1           1     1        1|     23  1.0|
      Skin, Site of Application, Ulcer     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 0| 5| 3| 3| 3| 0| 6| 6| 3| 8| 9| 8| 3| 3| 3| 3| 0| 1| 3| 4| 3|            |
                                           | 5| 0| 1| 1| 0| 6| 0| 1| 0| 9| 5| 8| 0| 9| 0| 4| 1| 0| 0| 1| 3| 7| 1| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    32 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                  4                          3            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 4                          3              3                          3   |      5  3.2|
      Fibrosis, Focal                      |                                  3                                       |      1  3.0|
      Inflammation, Granulomatous          |    1           1                    1                                    |      9  1.1|
      Mineralization                       |                                  4                          1            |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   2        |
      Cataract                             |                                                                   4      |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 1  4  3  2  2     2  3  3  2  2  4  1  3  2  1  2  3  3  3  4  4  3  1  2|     48  2.7|
      Renal Tubule, Mineralization         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 3| 7| 3| 7| 6| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 5| 6| 7| 7| 7| 1| 6| 7|             
                             DAY ON TEST   | 6| 7| 9| 2| 0| 2| 8| 2| 7| 1| 1| 2| 6| 0| 2| 2| 7| 8| 8| 2| 0| 2| 0| 7| 0|             
                                           | 1| 9| 4| 9| 2| 9| 3| 9| 0| 0| 7| 9| 1| 2| 9| 9| 0| 2| 7| 9| 2| 3| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                         2                                                |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                            X                                             |             
      Ulcer                                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X     X     X     X        X  X           X               |             
      Clear Cell Focus                     |                                           X                              |             
      Degeneration, Cystic                 |                      1                                   1               |             
      Degeneration, Fatty                  |          1                 1                 1                 3         |             
      Eosinophilic Focus                   |                                           X  X                           |             
      Hepatodiaphragmatic Nodule           |                                        X              X  X               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                   3                                                      |             
      Bile Duct, Hyperplasia               |                                                    4                     |             
      Centrilobular, Degeneration          | 3              2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                    +  +                                          |             
      Hemorrhage                           |                            3                                             |             
      Artery, Thrombosis                   |                               3                                          |             
      Fat, Necrosis                        |    3  2                                                                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                        +  +                 +            |             
      Inflammation, Suppurative            |                                                                          |             
      Gingival, Inflammation, Suppurative  |                                        3  2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1     1  1        4  1           1  2  1     1  1  1  2                  |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   2      |             
      Inflammation, Chronic                | 2                                                  4                     |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                 4     3        4     4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 3| 7| 3| 7| 6| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 5| 6| 7| 7| 7| 1| 6| 7|             
                             DAY ON TEST   | 6| 7| 9| 2| 0| 2| 8| 2| 7| 1| 1| 2| 6| 0| 2| 2| 7| 8| 8| 2| 0| 2| 0| 7| 0|             
                                           | 1| 9| 4| 9| 2| 9| 3| 9| 0| 0| 7| 9| 1| 2| 9| 9| 0| 2| 7| 9| 2| 3| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                3           3                                             |             
      Ulcer                                |       1                                                           2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +           +                                             |             
      Mineralization                       |                2           3                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             |    1     4  1  3     2  2  2  2  2  1     2  4  1  2     3  2  3     1  1|             
      Myocardium, Mineralization           |                                                                          |             
      Valve, Thrombosis                    |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2     1  2  1  1  3              2        1   |             
      Necrosis                             |                                              1                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1  1                    2  2        1     2     1     1        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            4                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Degeneration, Cystic  |                            3                       2                     |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           1                              |             
      C-Cell, Hyperplasia                  |          3     3  3  4     1  2  3  4  1  3  3  1     2  3  3  3     2  3|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |    1                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2        1                                                            |             
      Inflammation, Suppurative            |                                        3                                 |             
      Necrosis                             |                               4                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 3| 7| 3| 7| 6| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 5| 6| 7| 7| 7| 1| 6| 7|             
                             DAY ON TEST   | 6| 7| 9| 2| 0| 2| 8| 2| 7| 1| 1| 2| 6| 0| 2| 2| 7| 8| 8| 2| 0| 2| 0| 7| 0|             
                                           | 1| 9| 4| 9| 2| 9| 3| 9| 0| 0| 7| 9| 1| 2| 9| 9| 0| 2| 7| 9| 2| 3| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 3                 4        4  4     3           4     4     4           4|             
      Interstitial Cell, Hyperplasia       |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3     3        3     2                             2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4                     |             
      Inflammation, Acute                  |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                               3                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                                    4                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             | 2                                                     3           1      |             
      Necrosis                             |                      3                                                   |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Necrosis          |                                                    4                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4                     |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Cystic                  |                               1                                      2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrous Osteodystrophy               |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Choroid Plexus, Thrombosis           |                                        4                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 3| 7| 3| 7| 6| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 5| 6| 7| 7| 7| 1| 6| 7|             
                             DAY ON TEST   | 6| 7| 9| 2| 0| 2| 8| 2| 7| 1| 1| 2| 6| 0| 2| 2| 7| 8| 8| 2| 0| 2| 0| 7| 0|             
                                           | 1| 9| 4| 9| 2| 9| 3| 9| 0| 0| 7| 9| 1| 2| 9| 9| 0| 2| 7| 9| 2| 3| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Neuron, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Inflammation, Acute                  |                         2                                                |             
      Inflammation, Granulomatous          |                                           1        2           1         |             
      Mineralization                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Glands, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                       +                                   +            |             
      Inflammation, Acute                  |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3           3               |             
      Infarct                              |                         1  2                                             |             
      Inflammation, Acute                  |                         3                                                |             
      Nephropathy                          | 2  2  2  2  1  4  1  3     4  2  3  2  1  4  4  1  2  3  3  3  3     4  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                3                                                         |             
      Inflammation, Chronic                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 8| 1| 4| 9| 2| 8| 7| 8| 5| 8| 6| 9| 9| 0| 2| 6| 7| 0| 1| 2| 2| 2| 2| 6| 2|            |
                                           | 7| 9| 5| 5| 9| 7| 4| 0| 3| 9| 6| 6| 4| 7| 9| 3| 3| 2| 0| 9| 9| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                       X                  |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                               X                          X  X     X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                            2                    3                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |             X  X                 X     X  X              X     X        X|     15     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Degeneration, Fatty                  |                            4           3                                 |      6  2.2|
      Eosinophilic Focus                   |                                           X                    X         |      4     |
      Hepatodiaphragmatic Nodule           |                            X                             X     X         |      6     |
      Mixed Cell Focus                     |                            X                                             |      1     |
      Necrosis                             |                                                 1                        |      2  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  4.0|
      Centrilobular, Degeneration          |                                     1                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                          +        +                  |   7        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Artery, Thrombosis                   |                                              4                           |      2  3.5|
      Fat, Necrosis                        |                   3                                   2                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                   +  +  +                             +                  |   7        |
      Inflammation, Suppurative            |                   2  2  2                             3                  |      4  2.3|
      Gingival, Inflammation, Suppurative  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       2  3           3           1        1        1  2  2  1  1        1|     23  1.5|
      Artery, Inflammation, Chronic Active |                                                 1                        |      1  1.0|
      Artery, Thrombosis                   |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 8| 1| 4| 9| 2| 8| 7| 8| 5| 8| 6| 9| 9| 0| 2| 6| 7| 0| 1| 2| 2| 2| 2| 6| 2|            |
                                           | 7| 9| 5| 5| 9| 7| 4| 0| 3| 9| 6| 6| 4| 7| 9| 3| 3| 2| 0| 9| 9| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |       3                 3                                                |      4  3.0|
      Mineralization                       |                4                                                         |      1  4.0|
      Ulcer                                |                                              3  4     4                  |      7  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |                4     4                                                   |      4  3.5|
      Ulcer                                |                   3                 3           3  3                 2   |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +     +                                                   |   4        |
      Mineralization                       |                4     3                                                   |      4  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |       4                                         4                        |      2  4.0|
      Myocardium, Degeneration             | 2  3  3  3  4  3  1  3  1  1  1     2  1  3     1  2     2  3  3  2  1  2|     41  2.1|
      Myocardium, Mineralization           |                4                                                         |      1  4.0|
      Valve, Thrombosis                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2  2     1  1     1                    2              4           1   |     16  1.7|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                                         1                        |     11  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |    4                                                                     |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         2                                                |      1  2.0|
      Pars Distalis, Degeneration, Cystic  |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           |       1                                      1        1                 1|      4  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |    2  1     4  2  1     1  3  2           3        2  4     2  3     2  3|     33  2.5|
      Follicular Cell, Hyperplasia         |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 8| 1| 4| 9| 2| 8| 7| 8| 5| 8| 6| 9| 9| 0| 2| 6| 7| 0| 1| 2| 2| 2| 2| 6| 2|            |
                                           | 7| 9| 5| 5| 9| 7| 4| 0| 3| 9| 6| 6| 4| 7| 9| 3| 3| 2| 0| 9| 9| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                      4                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                      4                                                   |      2  3.5|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         | 4  4           4     4     4                       4                 3   |     16  3.8|
      Interstitial Cell, Hyperplasia       |                         1                                                |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       3  4  4           3                                   3            |     10  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +                          +                       +|   4        |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                         4                                                |      1  4.0|
      Ectasia                              |                   4                                                      |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                         3|      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                         2|      1  2.0|
      Fibrosis                             |                         3           2                    3        2      |      7  2.3|
      Necrosis                             |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           |                                           3                              |      1  3.0|
      Lymphoid Follicle, Necrosis          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Atrophy                              |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 8| 1| 4| 9| 2| 8| 7| 8| 5| 8| 6| 9| 9| 0| 2| 6| 7| 0| 1| 2| 2| 2| 2| 6| 2|            |
                                           | 7| 9| 5| 5| 9| 7| 4| 0| 3| 9| 6| 6| 4| 7| 9| 3| 3| 2| 0| 9| 9| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Cystic                  |                                  3     4                       3         |      5  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 3                        |      1  3.0|
      Fibrous Osteodystrophy               |    2           4                                                         |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Choroid Plexus, Thrombosis           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   2        |
      Neuron, Degeneration                 |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                            1                                            2|      5  1.4|
      Mineralization                       |                4     3                                                   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             2                                                            |      1  2.0|
      Inflammation, Suppurative            | 1                                            1                           |      2  1.0|
      Glands, Hyperplasia                  |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             4                                                            |      3  3.3|
      Infarct                              |                                                                          |      2  1.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Nephropathy                          | 4  4  2  2  4  4  1  4  3  4  2  3  4  4  2  2  3  4  3  3  3  3  3  2  2|     48  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 8| 1| 4| 9| 2| 8| 7| 8| 5| 8| 6| 9| 9| 0| 2| 6| 7| 0| 1| 2| 2| 2| 2| 6| 2|            |
                                           | 7| 9| 5| 5| 9| 7| 4| 0| 3| 9| 6| 6| 4| 7| 9| 3| 3| 2| 0| 9| 9| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 6| 6| 5| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 1| 3| 6| 6| 5| 6| 8| 2| 2| 0| 1| 2| 2| 2| 2| 7| 2| 9| 2| 7| 6|             
                                           | 4| 3| 2| 9| 9| 8| 3| 1| 4| 6| 1| 9| 9| 6| 0| 9| 5| 9| 9| 7| 9| 4| 3| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    16 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X              X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                            X                  |             
      Degeneration, Cystic                 |          2                          1                                    |             
      Degeneration, Fatty                  |             2                 2                                          |             
      Eosinophilic Focus                   |                                     X                                    |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Sinusoid, Congestion                 |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                            +                                             |             
      Inflammation, Suppurative            |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  2  1           2  3              1              1        1     1      |             
      Artery, Inflammation, Chronic Active |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             4                             3                              |             
      Epithelium, Hyperplasia              |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             | 2  2  2  2  2  2  2  4  3  2  2  2  2  1     3  3  1  1  2  1  3  2  2  1|             
      Myocardium, Mineralization           |                                                                          |             
      Valve, Degeneration                  |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 6| 6| 5| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 1| 3| 6| 6| 5| 6| 8| 2| 2| 0| 1| 2| 2| 2| 2| 7| 2| 9| 2| 7| 6|             
                                           | 4| 3| 2| 9| 9| 8| 3| 1| 4| 6| 1| 9| 9| 6| 0| 9| 5| 9| 9| 7| 9| 4| 3| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    16 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 2     2                             1                 1           4      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          3                                         3                     |             
      Hyperplasia                          |    1                       1              2  2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2     1                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3     3                 4                                      4      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    1              1     2                                                |             
      Pars Distalis, Hypoplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  3  3  2     1           2  3  3  3  2        3  3  4  3     3      |             
      Follicular Cell, Cyst                | 2                                                                       2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                  2                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       3           2        3                                      2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                            4     2                             4        4|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   4     3                             3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 6| 6| 5| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 1| 3| 6| 6| 5| 6| 8| 2| 2| 0| 1| 2| 2| 2| 2| 7| 2| 9| 2| 7| 6|             
                                           | 4| 3| 2| 9| 9| 8| 3| 1| 4| 6| 1| 9| 9| 6| 0| 9| 5| 9| 9| 7| 9| 4| 3| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    16 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                 3                        |             
      Fibrosis                             | 3  2           1                             1              3            |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Pigmentation, Hemosiderin            | 3                          3                                             |             
      Lymphoid Follicle, Atrophy           |                                                 3              3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3                    3     3                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |                                                       1                  |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                       1                 1|             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            1                                      2      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                    2                                                  3|             
      Hemorrhage, Focal                    |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
      Interstitium, Inflammation, Chronic  |    1                       2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Cataract                             |                                                                   3      |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 6| 6| 5| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 7| 5| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 1| 3| 6| 6| 5| 6| 8| 2| 2| 0| 1| 2| 2| 2| 2| 7| 2| 9| 2| 7| 6|             
                                           | 4| 3| 2| 9| 9| 8| 3| 1| 4| 6| 1| 9| 9| 6| 0| 9| 5| 9| 9| 7| 9| 4| 3| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    16 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
      Hydronephrosis                       |                                                                      2   |             
      Nephropathy                          |    3  3  3  4  2  3  2  1  4  3  3  3  2  2  2  3  2  3  2  2  3  4  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 5| 7| 6| 4| 6| 6| 6| 5| 5| 6| 5| 7| 6| 5| 6| 5| 5| 6| 6| 7| 6| 5|            |
                             DAY ON TEST   | 7| 0| 4| 7| 2| 4| 6| 7| 3| 7| 6| 4| 8| 9| 2| 4| 7| 3| 8| 6| 9| 4| 2| 7| 0|            |
                                           | 0| 2| 2| 2| 9| 0| 3| 3| 8| 0| 2| 1| 8| 9| 9| 2| 6| 9| 4| 0| 5| 8| 9| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    16 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X           X           X                                             |      5     |
      Degeneration, Cystic                 |                                                                          |      2  1.5|
      Degeneration, Fatty                  |          2                             4              3                  |      5  2.6|
      Eosinophilic Focus                   |                                           X                              |      2     |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      1     |
      Centrilobular, Degeneration          |                                                    2                     |      1  2.0|
      Centrilobular, Necrosis              |                         3                                                |      1  3.0|
      Sinusoid, Congestion                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                 +        +     +                           |   4        |
      Fat, Necrosis                        |                               3        3     3                           |      3  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                      +                                                   |   2        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1        4  2        2                 1     1  2     1  2            |     18  1.6|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          4                                                               |      1  4.0|
      Mineralization                       |                                                                      4   |      1  4.0|
      Ulcer                                | 3              3     2  3           2                          3         |      8  2.9|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    4                                                        4        4   |      3  4.0|
      Ulcer                                |                         3           2                          2         |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                        +        +   |   3        |
      Mineralization                       |    4                                                        4        4   |      3  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 5| 7| 6| 4| 6| 6| 6| 5| 5| 6| 5| 7| 6| 5| 6| 5| 5| 6| 6| 7| 6| 5|            |
                             DAY ON TEST   | 7| 0| 4| 7| 2| 4| 6| 7| 3| 7| 6| 4| 8| 9| 2| 4| 7| 3| 8| 6| 9| 4| 2| 7| 0|            |
                                           | 0| 2| 2| 2| 9| 0| 3| 3| 8| 0| 2| 1| 8| 9| 9| 2| 6| 9| 4| 0| 5| 8| 9| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    16 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                         4                                                |      1  4.0|
      Myocardium, Degeneration             | 1  3  2     2  2  1              2  2  3           3  2  3  3  3  3  3  1|     41  2.1|
      Myocardium, Mineralization           |                                                             3            |      1  3.0|
      Valve, Degeneration                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                         3|      1  3.0|
      Hyperplasia                          |    2  1  2  1  1                             3     1        1  1  2      |     15  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      2  3.0|
      Hyperplasia                          |                1              1                    2        3     3      |      9  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                                      2                     |      4  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    4                       4                          3     4        4   |      9  3.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           | 2           1  1     2        3                                          |      8  1.6|
      Pars Distalis, Hypoplasia            |                                                                         X|      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2  3     3  3  1  3  2  2     3  1  3  3  2  3  3  4  3  3  3  2  3      |     37  2.6|
      Follicular Cell, Cyst                |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3                                                                        |      3  2.7|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                    3           2         |      6  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |    4                       4  4                       4     4           4|     10  3.8|
      Interstitial Cell, Hyperplasia       |                                     4                                    |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 5| 7| 6| 4| 6| 6| 6| 5| 5| 6| 5| 7| 6| 5| 6| 5| 5| 6| 6| 7| 6| 5|            |
                             DAY ON TEST   | 7| 0| 4| 7| 2| 4| 6| 7| 3| 7| 6| 4| 8| 9| 2| 4| 7| 3| 8| 6| 9| 4| 2| 7| 0|            |
                                           | 0| 2| 2| 2| 9| 0| 3| 3| 8| 0| 2| 1| 8| 9| 9| 2| 6| 9| 4| 0| 5| 8| 9| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    16 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             4                                                            |      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                             +              +                           |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Erythrophagocytosis                  |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             | 3  3        3           3                                      3         |     10  2.5|
      Hematopoietic Cell Proliferation     |                                                             2            |      2  2.0|
      Pigmentation, Hemosiderin            |                                                    3                     |      3  3.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Epithelial Cell, Hyperplasia         |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Hyperplasia, Cystic                  |                                     3           4                        |      5  3.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      |                                                             1            |      2  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |             1                                                            |      3  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |             1  1                                                         |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |    3                                                        4            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 5| 7| 6| 4| 6| 6| 6| 5| 5| 6| 5| 7| 6| 5| 6| 5| 5| 6| 6| 7| 6| 5|            |
                             DAY ON TEST   | 7| 0| 4| 7| 2| 4| 6| 7| 3| 7| 6| 4| 8| 9| 2| 4| 7| 3| 8| 6| 9| 4| 2| 7| 0|            |
                                           | 0| 2| 2| 2| 9| 0| 3| 3| 8| 0| 2| 1| 8| 9| 9| 2| 6| 9| 4| 0| 5| 8| 9| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    16 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      3  2.3|
      Hemorrhage, Focal                    | 1                                                                        |      1  1.0|
      Mineralization                       |                                                                      3   |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |    3  2                 1        1                                       |      5  1.6|
      Interstitium, Inflammation, Chronic  |                                                             3            |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1     1  2                                2                           |      5  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Degeneration                         |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |       +                          +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                           3                 4            |      3  3.3|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 3  4  1  4  4  3  1  2  2  4  1  2     2  2  4  2  4  4  3  4  1  3  4  3|     48  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 5| 7| 6| 5| 7| 7| 7| 5| 4| 5|             
                             DAY ON TEST   | 1| 2| 0| 2| 8| 2| 2| 8| 0| 2| 9| 6| 1| 8| 0| 4| 2| 6| 2| 1| 0| 2| 0| 9| 9|             
                                           | 8| 9| 2| 9| 9| 9| 3| 1| 2| 9| 4| 3| 5| 1| 9| 2| 9| 4| 7| 5| 2| 9| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                            X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Muscularis, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                                         |             
      Clear Cell Focus                     |    X                                                                     |             
      Degeneration, Cystic                 |       2           1  1  2                                                |             
      Degeneration, Fatty                  | 2                                3  3  2  4                              |             
      Eosinophilic Focus                   |                            X                                             |             
      Hepatodiaphragmatic Nodule           |                            X     X                 X              X     X|             
      Centrilobular, Degeneration          |                                  2                                       |             
      Centrilobular, Necrosis              |                                                          3               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +  +              +  +              +   |             
      Artery, Inflammation, Chronic        |                      3                                                   |             
      Fat, Necrosis                        |                                  2  3              3                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                +         |             
      Gingival, Inflammation, Suppurative  |                               2                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  1  2     1              2     2     1     2  3     1     1         |             
      Artery, Thrombosis                   |    3                                                                     |             
      Duct, Atrophy                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
      Ulcer                                |             3     3                       2           2  3               |             
      Epithelium, Hyperplasia              |                                                             1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      3                                                   |             
      Ulcer                                | 1  2                                4                    1               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                          4               |             
      Myocardium, Degeneration             | 2  4     2  2  2  2  2  3  2  2  2  2     1  1  2  3     3  2  4  1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 5| 7| 6| 5| 7| 7| 7| 5| 4| 5|             
                             DAY ON TEST   | 1| 2| 0| 2| 8| 2| 2| 8| 0| 2| 9| 6| 1| 8| 0| 4| 2| 6| 2| 1| 0| 2| 0| 9| 9|             
                                           | 8| 9| 2| 9| 9| 9| 3| 1| 2| 9| 4| 3| 5| 1| 9| 2| 9| 4| 7| 5| 2| 9| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4  2        1                    3  3                 2        1   |             
      Hypertrophy                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3     1     2  4  2                          1           1        2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3     4     2        1                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Degeneration, Cystic  |                                                          1               |             
      Pars Distalis, Hyperplasia           |             1     2                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Follicular Cell, Cyst     |                                                                          |             
      C-Cell, Hyperplasia                  | 2  2  3  2  1  3  2     2  4  2  4  3  3  3  3     2  4  4  2  3     1  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                   2     1                    1           1  1            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          3               |             
      Inflammation, Suppurative            |             3        4                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |       4     4           4     4           4                 4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Hyperplasia                          |          3  4           3     3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                                   +           +   |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 5| 7| 6| 5| 7| 7| 7| 5| 4| 5|             
                             DAY ON TEST   | 1| 2| 0| 2| 8| 2| 2| 8| 0| 2| 9| 6| 1| 8| 0| 4| 2| 6| 2| 1| 0| 2| 0| 9| 9|             
                                           | 8| 9| 2| 9| 9| 9| 3| 1| 2| 9| 4| 3| 5| 1| 9| 2| 9| 4| 7| 5| 2| 9| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 2              2         |             
      Fibrosis                             |       3           3     3                          1                     |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |                               3                    3     3               |             
      Duct, Dilatation                     |                                     4                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Skin, Site of Application,   |                                                                          |             
           Fibrosis                        |                                     2                                    |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |          1                                         1                     |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Erosion                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |       1                 1                       1                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Suppurative              |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Medulla, Demyelination, Focal        |                                                                          |             
      Medulla, Necrosis, Focal             |                         2                                                |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |       1                                            2                     |             
      Alveolar Epithelium, Hyperplasia     |                                           1                              |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 5| 7| 6| 5| 7| 7| 7| 5| 4| 5|             
                             DAY ON TEST   | 1| 2| 0| 2| 8| 2| 2| 8| 0| 2| 9| 6| 1| 8| 0| 4| 2| 6| 2| 1| 0| 2| 0| 9| 9|             
                                           | 8| 9| 2| 9| 9| 9| 3| 1| 2| 9| 4| 3| 5| 1| 9| 2| 9| 4| 7| 5| 2| 9| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    32 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +                                                |             
      Cataract                             |             3           4                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         4|             
      Nephropathy                          | 3  3  2  2  2  3  3  4  4  2  2  2  3  3  3  3  3  3  2  2  3  3  1  1  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 5| 2| 6| 3| 2| 2| 2| 2| 2| 1| 2| 3| 2| 5| 2| 2| 2| 2| 0| 2| 2| 2| 1|            |
                                           | 9| 1| 9| 9| 8| 3| 9| 9| 9| 9| 9| 0| 9| 5| 9| 6| 9| 9| 9| 9| 2| 2| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    32 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                 X                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X        X                    X               |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Muscularis, Inflammation, Chronic    |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                            X              X                              |      3     |
      Degeneration, Cystic                 |                                                                      2   |      5  1.6|
      Degeneration, Fatty                  |             2  2                    2                          2         |      9  2.4|
      Eosinophilic Focus                   |                                                                      X   |      2     |
      Hepatodiaphragmatic Nodule           |       X                 X              X                                 |      8     |
      Centrilobular, Degeneration          |    1                                                                     |      2  1.5|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                +                           |   8        |
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Fat, Necrosis                        |             4                                                            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Gingival, Inflammation, Suppurative  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       3  2           3     1  2  2        1  2     3  2  1  1     1  1  4|     26  1.8|
      Artery, Thrombosis                   |                                                                          |      1  3.0|
      Duct, Atrophy                        |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                             3            |      2  2.5|
      Ulcer                                |             3                          4                       3     3   |      9  2.9|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                2         |      2  2.5|
      Ulcer                                |    1                                                                     |      5  1.8|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                      +                                                   |   1        |
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 5| 2| 6| 3| 2| 2| 2| 2| 2| 1| 2| 3| 2| 5| 2| 2| 2| 2| 0| 2| 2| 2| 1|            |
                                           | 9| 1| 9| 9| 8| 3| 9| 9| 9| 9| 9| 0| 9| 5| 9| 6| 9| 9| 9| 9| 2| 2| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    32 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Myocardium, Degeneration             | 2     3  3  2  2  2  3  2  3  4     2  3  3  1  2  3  4  3  1  1  2  3  1|     44  2.3|
      Myocardium, Mineralization           |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  2        4        2     1  1  4  2      |     15  2.3|
      Hypertrophy                          |                   3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3                          2     1        3           2     3  2         |     15  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                                                                        |      5  2.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Degeneration, Cystic  |                                           2                              |      2  1.5|
      Pars Distalis, Hyperplasia           | 1                          3              2     1     1                  |      7  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Follicular Cell, Cyst     |                            3                                             |      1  3.0|
      C-Cell, Hyperplasia                  | 3  1  3  2     1  3     4        3  2  3  4  3  3  3  3  4  3     3  3  3|     42  2.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                           3                              |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                              3                           |      3  3.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                         4              4              4     4  4         |     11  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 5| 2| 6| 3| 2| 2| 2| 2| 2| 1| 2| 3| 2| 5| 2| 2| 2| 2| 0| 2| 2| 2| 1|            |
                                           | 9| 1| 9| 9| 8| 3| 9| 9| 9| 9| 9| 0| 9| 5| 9| 6| 9| 9| 9| 9| 2| 2| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    32 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia                          |                                        4                 3           2   |      7  3.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +  +                           |   5        |
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                          2               |      3  2.0|
      Fibrosis                             |             2                    2        3                       3  3   |      9  2.6|
      Hematopoietic Cell Proliferation     |                                        3     4                           |      3  3.7|
      Pigmentation, Hemosiderin            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +|  45        |
      Hyperplasia, Cystic                  |                         4                                            4   |      5  3.4|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Fibrosis                        |                                                                          |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      |       1                                   1                              |      4  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Erosion                         | 1                                                                        |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |                                           1           1                  |      2  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  | 1                                         1                              |      5  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Suppurative              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 5| 2| 6| 3| 2| 2| 2| 2| 2| 1| 2| 3| 2| 5| 2| 2| 2| 2| 0| 2| 2| 2| 1|            |
                                           | 9| 1| 9| 9| 8| 3| 9| 9| 9| 9| 9| 0| 9| 5| 9| 6| 9| 9| 9| 9| 2| 2| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    32 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |                                  3     3                    2            |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Medulla, Demyelination, Focal        |    2                                                                     |      1  2.0|
      Medulla, Necrosis, Focal             |                                                                      2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |      2  1.0|
      Interstitium, Inflammation, Chronic  |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                        2                       2     1   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        4                                 |      2  4.0|
      Nephropathy                          | 3  2  3  3  1  3  2  2  2  3  2  4  2  4  3  2  1  3  4  2  4  4  3  3  2|     50  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 2| 7| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 2| 2| 3| 0| 8| 7| 2| 8| 2| 7| 2| 2| 3| 2| 2| 2| 3| 4| 4| 2|             
                                           | 9| 9| 9| 9| 1| 9| 9| 2| 1| 9| 7| 9| 7| 9| 7| 8| 1| 0| 9| 9| 2| 3| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X  X                                                               |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
      Ulcer                                |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                    X     X               |             
      Clear Cell Focus                     |                                  X                                       |             
      Degeneration, Cystic                 |                                  1                                      1|             
      Degeneration, Fatty                  | 2                                               1                        |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                             2            |             
      Centrilobular, Degeneration          |                                                                          |             
      Midzonal, Vacuolization Cytoplasmic  |             1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +     +                                                   |             
      Fat, Necrosis                        |                4     3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  2        1  1        4     2  2  1  1  2  1           3  2     1  2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                | 3                    4     3                 2     3                     |             
      Epithelium, Hyperplasia              |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                        1                                 |             
      Atrium, Thrombosis                   |                         3                                                |             
      Myocardium, Degeneration             | 2  2  3  1  1  3  2  1        2  3  1  2  1  2  1     2  2  2  1  1  2  3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 2| 7| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 2| 2| 3| 0| 8| 7| 2| 8| 2| 7| 2| 2| 3| 2| 2| 2| 3| 4| 4| 2|             
                                           | 9| 9| 9| 9| 1| 9| 9| 2| 1| 9| 7| 9| 7| 9| 7| 8| 1| 0| 9| 9| 2| 3| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2           2        2     2  4                    1                 1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4  2  3     2  3                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Degeneration, Cystic  |                   3                                                      |             
      Pars Distalis, Hyperplasia           |          3                 2  2        1                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   1      |             
      C-Cell, Hyperplasia                  | 3  2  3  3  3  2  3        1  2  3                    3  2     2     2   |             
      Follicular Cell, Cyst                |                                                             3           3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
      Inflammation, Granulomatous          |                      1                                         2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                3              3                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                   4        4                                             |             
      Interstitial Cell, Hyperplasia       |                3                                                     3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4           3     3                                   3  2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                                      |             
      Mediastinal, Ectasia                 |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 2| 7| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 2| 2| 3| 0| 8| 7| 2| 8| 2| 7| 2| 2| 3| 2| 2| 2| 3| 4| 4| 2|             
                                           | 9| 9| 9| 9| 1| 9| 9| 2| 1| 9| 7| 9| 7| 9| 7| 8| 1| 0| 9| 9| 2| 3| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  M  +  M  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Suppurative            |       3                                                                  |             
      Dermis, Skin, Site of Application,   |                                                                          |             
           Fibrosis                        |                                                                          |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Acanthosis                      |                                           1                          1   |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Degeneration                    |                                           2                              |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Exudate                         |                   1                                         1            |             
      Epidermis, Skin, Site of Application,|                                                                          |             
           Hyperkeratosis                  |       1           1     1                    1              1            |             
      Skin, Site of Application, Ulcer     |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Hyperostosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                      +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
      Gliosis                              |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
      Bronchus, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
      Bronchus, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 2| 7| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 2| 2| 3| 0| 8| 7| 2| 8| 2| 7| 2| 2| 3| 2| 2| 2| 3| 4| 4| 2|             
                                           | 9| 9| 9| 9| 1| 9| 9| 2| 1| 9| 7| 9| 7| 9| 7| 8| 1| 0| 9| 9| 2| 3| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1                             2                    2           3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Lens, Cataract                       |                               3                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Cyst                                 |                                  4                                       |             
      Nephropathy                          | 4  3  1  3  3  2  3  3  2     1  2  2  3  1  2  3  3  2  2  3  2  2  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 3| 6|            |
                             DAY ON TEST   | 5| 8| 2| 4| 2| 2| 2| 3| 2| 2| 2| 4| 6| 0| 2| 6| 4| 2| 8| 0| 2| 4| 2| 7| 5|            |
                                           | 6| 8| 9| 3| 9| 9| 9| 3| 9| 9| 9| 2| 1| 9| 9| 5| 0| 9| 8| 9| 9| 1| 9| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    64 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X                                                   |      3     |
      Ulcer                                |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                X                                                        X|      3     |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                                                   X      |      2     |
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Degeneration, Fatty                  |       1                 2                 2           1        3         |      7  1.7|
      Eosinophilic Focus                   |                   X              X                                       |      2     |
      Hepatodiaphragmatic Nodule           |       X                 X                             X        X         |      4     |
      Mixed Cell Focus                     |                                                    X                     |      1     |
      Necrosis                             |                                                                          |      1  2.0|
      Centrilobular, Degeneration          |                                                                      2   |      1  2.0|
      Midzonal, Vacuolization Cytoplasmic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   3        |
      Fat, Necrosis                        |       2                                                                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |             2     1        1  3     2                    1  2     1  1   |     24  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                         3                                               3|      2  3.0|
      Ulcer                                | 1  4                                   2                       3     1   |     10  2.6|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |          4                                                               |      1  4.0|
      Ulcer                                |          2                                      3                    3   |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 3| 6|            |
                             DAY ON TEST   | 5| 8| 2| 4| 2| 2| 2| 3| 2| 2| 2| 4| 6| 0| 2| 6| 4| 2| 8| 0| 2| 4| 2| 7| 5|            |
                                           | 6| 8| 9| 3| 9| 9| 9| 3| 9| 9| 9| 2| 1| 9| 9| 5| 0| 9| 8| 9| 9| 1| 9| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    64 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                      3   |      2  3.0|
      Myocardium, Degeneration             | 1  2  1  2  2  1  2  2  4  2  3        1  3  1  2  1  1  2  3  2  3  1  1|     45  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2        1     3              1           1                           |     12  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3     1              1                                       |      8  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         4     2                    1                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                      3   |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                      3   |      1  3.0|
      Pars Distalis, Degeneration, Cystic  |                                                                      2   |      2  2.5|
      Pars Distalis, Hyperplasia           |       1                                   2                 1     2      |      8  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |    1  2     3  3  3  2  2  4  4  1  2     3     2  3  1     3  2  3     2|     33  2.4|
      Follicular Cell, Cyst                |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           2                              |      2  2.5|
      Inflammation, Granulomatous          |                                                          3               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          3                                                           1   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                          3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         | 4  3                       4        4  3                 4     3         |      9  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 3| 6|            |
                             DAY ON TEST   | 5| 8| 2| 4| 2| 2| 2| 3| 2| 2| 2| 4| 6| 0| 2| 6| 4| 2| 8| 0| 2| 4| 2| 7| 5|            |
                                           | 6| 8| 9| 3| 9| 9| 9| 3| 9| 9| 9| 2| 1| 9| 9| 5| 0| 9| 8| 9| 9| 1| 9| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    64 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3        3                                   3        3               |      9  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +               |   2        |
      Mediastinal, Ectasia                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                               1  2                                       |      2  1.5|
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  42        |
      Hyperplasia, Cystic                  |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Fibrosis                        |                      2                                                   |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Acanthosis                      |       1     1  1  1        1              1                 2           1|     10  1.1|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    |                                                                         1|      2  1.5|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Exudate                         |             1                             1              1  1           1|      7  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperkeratosis                  |                            1              1              1  1  1     1   |     11  1.0|
      Skin, Site of Application, Ulcer     |                            1                                             |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Hyperostosis               |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05162-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 10:20:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 3| 6|            |
                             DAY ON TEST   | 5| 8| 2| 4| 2| 2| 2| 3| 2| 2| 2| 4| 6| 0| 2| 6| 4| 2| 8| 0| 2| 4| 2| 7| 5|            |
                                           | 6| 8| 9| 3| 9| 9| 9| 3| 9| 9| 9| 2| 1| 9| 9| 5| 0| 9| 8| 9| 9| 1| 9| 9| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    64 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Gliosis                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                    1                     |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |      2  1.5|
      Bronchus, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                                2         |      1  2.0|
      Bronchus, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                2         |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                              1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |       2           1              2                       2     2         |      9  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   2        |
      Lens, Cataract                       |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        | 3                                                                        |      1  3.0|
      Cyst                                 |                                                             3            |      2  3.5|
      Nephropathy                          | 2  1     2  3  3  3  1  3  3  3  2  2  2  2  3  2  3  3  3  3  3  3  2  2|     48  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |          4                                                               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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