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TDMS Study 05162-10 Pathology Tables

NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96
Route: SKIN APPLICATION                                                                                           Time: 11:08:11

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  111-42-2

       Lock Date:  06/04/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            9            8           14                                     
    Moribund Sacrifice                                 4            8            9           13                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           33           33           22                                     
    Natural Death                                                                             1                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Clear Cell Focus                                              2 (4%)                                                          
      Eosinophilic Focus                               3 (6%)       4 (8%)                                                          
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)                                             
      Syncytial Alteration                                          2 (4%)      17 (34%)     18 (36%)                               
      Hepatocyte, Vacuolization Cytoplasmic            1 (2%)                                                                       
      Periportal, Kupffer Cell, Amyloid Deposition     1 (2%)                                                                       
   Mesentery                                          (4)          (5)          (1)          (2)                                    
      Fat, Inflammation, Chronic                       3 (75%)      4 (80%)                   1 (50%)                               
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Acinus, Atrophy                                               2 (4%)                                                          
      Acinus, Cytoplasmic Alteration, Focal            1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
      Duct, Cytoplasmic Alteration                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Hyperplasia, Focal, Squamous                     1 (2%)       6 (12%)      5 (10%)                                            
      Mineralization, Diffuse                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Necrosis, Focal                                                                         3 (6%)                                
   Tooth                                              (1)                                                                           
      Developmental Malformation                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Atrium, Thrombosis                                                         1 (2%)       4 (8%)                                
      Myocardium, Degeneration, Acute                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Degeneration, Diffuse                                                                   1 (2%)                                
      Hemorrhage                                                                 1 (2%)       4 (8%)                                
      Hypertrophy, Diffuse                             1 (2%)                                                                       
      Hypertrophy, Focal                                                                      1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Zona Reticularis, Pigmentation                   1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia, Focal                                            2 (4%)       1 (2%)       2 (4%)                                
   Pituitary Gland                                    (50)         (50)         (47)         (44)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Hemorrhage, Focal                              1 (2%)                                                          
      Pars Distalis, Hyperplasia                       4 (8%)       4 (8%)       3 (6%)       1 (2%)                                
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Follicle, Cyst                                                             1 (2%)       1 (2%)                                
      Follicular Cell, Hyperplasia                    18 (36%)     28 (56%)     32 (64%)     39 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (46)         (43)                                   
      Cyst                                                          1 (2%)                                                          
   Ovary                                              (49)         (50)         (49)         (49)                                   
      Atrophy                                         42 (86%)     35 (70%)     44 (90%)     49 (100%)                              
      Thrombosis                                       1 (2%)                    1 (2%)       1 (2%)                                
      Follicle, Cyst                                  10 (20%)     18 (36%)     12 (24%)     10 (20%)                               
      Periovarian Tissue, Cyst                                      1 (2%)       1 (2%)       1 (2%)                                
      Periovarian Tissue, Inflammation,                                                                                             
          Granulomatous                                1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                                 1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Endometrium, Hyperplasia, Cystic                45 (90%)     44 (88%)     31 (62%)     25 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Myelofibrosis                                   14 (28%)     19 (38%)     11 (22%)      8 (16%)                               
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (2%)       1 (2%)                                             
   Lymph Node                                         (9)          (2)          (5)                                                 
      Lumbar, Infiltration Cellular, Plasma Cell       1 (11%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (11%)                                                                      
      Pancreatic, Inflammation, Granulomatous          1 (11%)                                                                      
   Lymph Node, Mandibular                             (46)         (48)         (46)         (43)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
      Necrosis                                         1 (2%)                                 3 (7%)                                
   Lymph Node, Mesenteric                             (48)         (48)         (44)         (40)                                   
      Congestion                                                                 1 (2%)                                             
      Necrosis                                         2 (4%)       3 (6%)       2 (5%)       7 (18%)                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                24 (48%)     31 (62%)     41 (82%)     43 (86%)                               
      Hyperplasia, Lymphoid                                         2 (4%)                    1 (2%)                                
      Pigmentation, Diffuse, Hemosiderin               1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Lymphoid Follicle, Depletion Cellular                         1 (2%)                                                          
   Thymus                                             (48)         (42)         (41)         (36)                                   
      Atrophy                                          3 (6%)       6 (14%)      8 (20%)     21 (58%)                               
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Necrosis                                                      6 (14%)      3 (7%)       4 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (47)         (47)         (40)                                   
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Skin, Site of Application, Acanthosis                         2 (4%)       1 (2%)       2 (4%)                                
      Skin, Site of Application, Exudate                            1 (2%)       1 (2%)       3 (6%)                                
      Skin, Site of Application, Hyperkeratosis        1 (2%)       3 (6%)       8 (16%)     16 (32%)                               
      Skin, Site of Application, Ulcer                              1 (2%)                                                          
      Subcutaneous Tissue, Edema, Diffuse                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
      Inflammation, Granulomatous                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hydrocephalus                                    1 (2%)                                                                       
      Cerebrum, Cyst Epithelial Inclusion              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    2 (4%)       1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte                                2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)          (2)                                    
      Degeneration                                                                            2 (100%)                              
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Metaplasia, Focal, Osseous                       2 (4%)                                                                       
      Nephropathy                                     25 (50%)     24 (48%)     16 (32%)     17 (34%)                               
      Cortex, Cyst                                     1 (2%)                    1 (2%)                                             
      Cortex, Infarct                                  1 (2%)                                 2 (4%)                                
      Glomerulus, Amyloid Deposition                   1 (2%)                                                                       
      Renal Tubule, Dilatation                                                   1 (2%)                                             
      Renal Tubule, Mineralization                                  4 (8%)       3 (6%)                                             
      Renal Tubule, Pigmentation                                    1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)         (50)         (48)                                   
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            6           10            9                                     
    Moribund Sacrifice                                 3            1            6           10                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           41           34           30                                     
    Natural Death                                                   2                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (50)         (50)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid                        1 (2%)                                                          
      Lymphoid Tissue, Inflammation, Chronic Active                              1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (49)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 2 (4%)       1 (2%)                                                          
      Clear Cell Focus                                 4 (8%)       7 (14%)      2 (4%)       2 (4%)                                
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Eosinophilic Focus                               3 (6%)       4 (8%)       2 (4%)       4 (8%)                                
      Eosinophilic Focus, Multiple                                                            1 (2%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hematopoietic Cell Proliferation, Diffuse                     1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Necrosis                                         2 (4%)                                                                       
      Syncytial Alteration                                         28 (56%)     38 (76%)     23 (46%)                               
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Centrilobular, Cytoplasmic Alteration            1 (2%)      17 (34%)     17 (34%)     12 (24%)                               
   Mesentery                                          (1)                                                                           
      Fat, Inflammation, Chronic                       1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                  2 (4%)       2 (4%)                    1 (2%)                                
      Acinus, Cytoplasmic Alteration                   1 (2%)                    1 (2%)       3 (6%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Duct, Cytoplasmic Alteration                     1 (2%)       2 (4%)       8 (16%)     23 (46%)                               
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Hyperplasia, Focal, Squamous                     1 (2%)       4 (8%)       4 (8%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Pigmentation                                                               3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Epithelium, Hyperplasia, Focal                                1 (2%)                    2 (4%)                                
   Tooth                                              (3)          (2)                                                              
      Developmental Malformation                       1 (33%)      2 (100%)                                                        
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       2 (67%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
      Adventitia, Inflammation, Chronic                                                       1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Atrium, Thrombosis                                                                      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                                         1 (2%)       3 (6%)                                
      Hypertrophy, Diffuse                             1 (2%)                                                                       
      Hypertrophy, Focal                               6 (12%)      8 (16%)      4 (8%)       7 (14%)                               
      Vacuolization Cytoplasmic, Focal                                           1 (2%)                                             
      Capsule, Hyperplasia                             2 (4%)       6 (12%)      5 (10%)      3 (6%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)                                                                       
   Parathyroid Gland                                  (41)         (41)         (41)         (43)                                   
      Cyst                                                          1 (2%)                                                          
   Pituitary Gland                                    (48)         (47)         (46)         (43)                                   
      Craniopharyngeal Duct, Pars Distalis, Cyst       1 (2%)                                                                       
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)       3 (7%)                                
      Pars Distalis, Hyperplasia                       2 (4%)                                                                       
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Follicular Cell, Hyperplasia                    18 (36%)     22 (45%)     30 (60%)     42 (84%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Pelvic, Abscess                                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                                         1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                            16 (32%)     12 (24%)     20 (40%)     12 (24%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     3 (6%)       5 (10%)      1 (2%)       3 (6%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Diffuse, Suppurative                            1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Diffuse, Suppurative                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Myeloid Cell, Depletion Cellular                                           1 (2%)                                             
   Lymph Node                                         (1)          (2)          (1)                                                 
      Hyperplasia, Lymphoid                                         1 (50%)                                                         
   Lymph Node, Mandibular                             (46)         (46)         (44)         (36)                                   
      Necrosis                                                      3 (7%)       2 (5%)       2 (6%)                                
   Lymph Node, Mesenteric                             (45)         (43)         (41)         (41)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       2 (4%)                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Necrosis                                                      4 (9%)       1 (2%)       6 (15%)                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                13 (26%)     22 (44%)     29 (58%)     32 (64%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Lymphoid Follicle, Necrosis                      1 (2%)                                                                       
      Red Pulp, Depletion Cellular                     1 (2%)                                                                       
   Thymus                                             (37)         (42)         (39)         (36)                                   
      Atrophy                                          8 (22%)      8 (19%)     18 (46%)     17 (47%)                               
      Cyst                                                          1 (2%)                                                          
      Necrosis                                         2 (5%)       1 (2%)       3 (8%)       2 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperkeratosis                                                                          1 (2%)                                
      Dermis, Fibrosis                                                                        1 (2%)                                
      Skin, Site of Application, Acanthosis                                      2 (4%)       4 (8%)                                
      Skin, Site of Application, Exudate                                                      3 (6%)                                
      Skin, Site of Application, Hyperkeratosis                    13 (26%)     10 (20%)     17 (34%)                               
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic                                                                            1 (2%)                                
      Skin, Site of Application, Ulcer                 1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Angiectasis                 1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
      Subcutaneous Tissue, Fibrosis                                              1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Diffuse, Granulomatous                                       1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                   1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                2 (4%)                    1 (2%)                                             
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Nephropathy                                     45 (90%)     47 (94%)     45 (90%)     48 (96%)                               
      Cortex, Cyst                                                  5 (10%)      2 (4%)                                             
      Cortex, Infarct                                               1 (2%)                                                          
      Glomerulus, Dilatation, Diffuse                  1 (2%)                    1 (2%)       1 (2%)                                
      Glomerulus, Dilatation, Focal                   22 (44%)     39 (78%)     39 (78%)     32 (64%)                               
      Pelvis, Inflammation, Suppurative                             1 (2%)                                                          
      Renal Tubule, Dilatation                                      1 (2%)                                                          
      Renal Tubule, Hyperplasia, Focal                 1 (2%)       2 (4%)                    3 (6%)                                
      Renal Tubule, Mineralization                    38 (76%)     45 (90%)     38 (76%)     41 (82%)                               
      Renal Tubule, Pigmentation, Hemosiderin                       1 (2%)       2 (4%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05162-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:08:11  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Vacuolization Cytoplasmic                                                 1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
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