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TDMS Study 05162-10 Pathology Tables

NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96
Route: SKIN APPLICATION                                                                                           Time: 11:55:25

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  111-42-2

       Lock Date:  06/04/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            9            8           14                                     
    Moribund Sacrifice                                 4            8            9           13                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           33           33           22                                     
    Natural Death                                                                             1                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
      Hepatoblastoma                                                2 (4%)       1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma                         5 (10%)     13 (26%)     17 (34%)     16 (32%)                               
      Hepatocellular Carcinoma, Multiple                            6 (12%)     21 (42%)     26 (52%)                               
      Hepatocellular Adenoma                          16 (32%)      7 (14%)      2 (4%)       3 (6%)                                
      Hepatocellular Adenoma, Multiple                16 (32%)     43 (86%)     46 (92%)     45 (90%)                               
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Mesentery                                          (4)          (5)          (1)          (2)                                    
      Fat, Fibrosarcoma                                             1 (20%)                                                         
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Capsule, Adenoma                                                                        1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Benign                          2 (4%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (47)         (44)                                   
      Pars Distalis, Adenoma                           7 (14%)                   3 (6%)       1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Follicular Cell, Adenoma                         3 (6%)       8 (16%)      7 (14%)      3 (6%)                                
      Follicular Cell, Adenoma, Multiple               1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (46)         (43)                                   
   Ovary                                              (49)         (50)         (49)         (49)                                   
      Cystadenoma                                      2 (4%)                                                                       
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
      Hemangioma                                       3 (6%)                                 1 (2%)                                
      Teratoma Benign                                                            1 (2%)                                             
      Teratoma Malignant                                                                      1 (2%)                                
      Periovarian Tissue, Histiocytic Sarcoma                                                 1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Polyp Stromal                                    3 (6%)       2 (4%)       2 (4%)                                             
      Cervix, Histiocytic Sarcoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Lymph Node                                         (9)          (2)          (5)                                                 
      Inguinal, Sarcoma                                1 (11%)                                                                      
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                 1 (50%)                                                         
      Renal, Fibrous Histiocytoma                                                1 (20%)                                            
   Lymph Node, Mandibular                             (46)         (48)         (46)         (43)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Histiocytic Sarcoma                                                                     2 (5%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (48)         (44)         (40)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (3%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)                                                                       
      Histiocytic Sarcoma                                                                     2 (4%)                                
      Capsule, Fibrosarcoma, Metastatic, Mesentery                  1 (2%)                                                          
   Thymus                                             (48)         (42)         (41)         (36)                                   
      Histiocytic Sarcoma                                                                     1 (3%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (47)         (47)         (40)                                   
      Carcinoma                                        1 (2%)                    2 (4%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sebaceous Gland,                                                                                         
          Squamous Cell Carcinoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Pinna, Fibroma                                        1 (2%)                                             
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrosarcoma                                 1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Sarcoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Mast Cell Tumor Malignant                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)       2 (4%)                                             
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Hepatocellular Carcinoma, Metastatic, Liver                   3 (6%)       6 (12%)      1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
      Mediastinum, Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                          
   Nose                                               (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (2)          (1)          (3)                                    
      Adenoma                                          1 (100%)     1 (50%)      1 (100%)     2 (67%)                               
      Carcinoma                                                     1 (50%)                   1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
   Urinary Bladder                                    (50)         (49)         (50)         (48)                                   
      Fibrosarcoma, Metastatic, Mesentery                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    2 (4%)                                
      Lymphoma Malignant                              12 (24%)      6 (12%)     11 (22%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          50          50          50                                       
     Total Primary Neoplasms                           90          98         128         107                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          50          49          48                                       
     Total Benign Neoplasms                            62          64          68          58                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          26          44          44                                       
     Total Malignant Neoplasms                         28          34          60          49                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          8           6           1                                       
     Total Metastatic Neoplasm                                     15           7           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            6           10            9                                     
    Moribund Sacrifice                                 3            1            6           10                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           41           34           30                                     
    Natural Death                                                   2                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (49)         (50)         (50)                                   
      Carcinoma                                                                  3 (6%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            2 (4%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatoblastoma                                                2 (4%)       8 (16%)      5 (10%)                               
      Hepatocellular Carcinoma                        10 (20%)     12 (24%)     19 (38%)     17 (34%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)       5 (10%)     14 (28%)     17 (34%)                               
      Hepatocellular Adenoma                          19 (38%)      6 (12%)      2 (4%)       4 (8%)                                
      Hepatocellular Adenoma, Multiple                12 (24%)     36 (72%)     47 (94%)     41 (82%)                               
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Capsule, Adenoma                                 5 (10%)      8 (16%)      1 (2%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (48)         (47)         (46)         (43)                                   
      Pars Intermedia, Adenoma                         1 (2%)                                 2 (5%)                                
                                                             Page   7                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Follicular Cell, Adenoma                         4 (8%)       5 (10%)      4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Leiomyoma                                        1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                       2 (4%)                    2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)                                             
   Lymph Node                                         (1)          (2)          (1)                                                 
      Mediastinal, Plasma Cell Tumor Malignant         1 (100%)                                                                     
   Lymph Node, Mandibular                             (46)         (46)         (44)         (36)                                   
   Lymph Node, Mesenteric                             (45)         (43)         (41)         (41)                                   
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       4 (8%)                                                          
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
   Thymus                                             (37)         (42)         (39)         (36)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibroma                     1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Pinna, Fibroma                           1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Lymphoma Malignant                           1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Osteosarcoma, Metastatic,                                                                                    
           Bone                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Rib, Carcinoma, Metastatic, Islets,                                                                                           
          Pancreatic                                   1 (2%)                                                                       
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
   Skeletal Muscle                                                 (2)          (3)                                                 
      Hemangiosarcoma                                               1 (50%)                                                         
      Hepatoblastoma, Metastatic, Liver                                          1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     9 (18%)     13 (26%)      9 (18%)      4 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)       2 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      1 (2%)       3 (6%)                                             
      Hepatoblastoma, Metastatic, Liver                                          2 (4%)       3 (6%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       4 (8%)       7 (14%)      4 (8%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Mediastinum, Carcinoma, Metastatic, Islets,                                                                                   
           Pancreatic                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (2)          (1)                                    
      Adenoma                                                       1 (100%)     2 (100%)                                           
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)       4 (8%)       4 (8%)       6 (12%)                               
      Renal Tubule, Adenoma, Multiple                                            2 (4%)                                             
      Renal Tubule, Carcinoma                          2 (4%)       1 (2%)                    2 (4%)                                
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant                                            1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05162-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 06/11/96  
Route: SKIN APPLICATION                                                                                           Time: 11:55:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      40 MG/KG     80 MG/KG     160                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          49          50          49                                       
     Total Primary Neoplasms                           85         106         128         109                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          45          49          45                                       
     Total Benign Neoplasms                            57          77          76          64                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          22          38          35                                       
     Total Malignant Neoplasms                         28          29          52          45                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           4           9           8                                       
     Total Metastatic Neoplasm                          6           4          10          10                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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