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TDMS Study 05163-01 Pathology Tables

NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97
Route: DOSED WATER                                                                                                Time: 14:01:30




       Facility:  Hazleton Laboratories America, Inc.

       Chemical CAS #:  6459-94-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                          +  +  +  +  +   |             
      Adventitia, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                          +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                          +  +  +  +  +   |             
      Adenoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                                             X  X  X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                          +  +  +  +  +   |             
      C-Cell, Adenoma                      |                                                                   X      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                          +  +  M  +  +   |             
      Adenoma                              |                                                                   X  X   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal                      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +  +  +  +  +   |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                          +  +  +  +  +   |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                          +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                                             X     X  X   |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                          +  +  +  +  +   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                          +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                          +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                                                          +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adventitia, Leukemia Mononuclear     |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                       X     X                 X        X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +     +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X        X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X        X  X   |             
      Pheochromocytoma Benign              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                               X               |             
      Pars Distalis, Adenoma               |       X           X        X  X  X  X  X  X  X  X                       X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                         X                 X                 X            |             
      C-Cell, Carcinoma                    |          X                    X                    X  X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                       X                    X     X   |             
      Carcinoma                            |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X           X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Polyp Stromal                        |                                              X                          X|             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                          X               |             
      Pancreatic, Leukemia Mononuclear     |          X                                               X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                               X        X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                               X        X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                 X     X                 X        X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Adenoma                              |                                           X                              |             
      Fibroadenoma                         | X  X  X        X  X                       X  X  X                 X      |             
      Fibroadenoma, Multiple               |                                     X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic                |                                                                          |             
      Leukemia Mononuclear                 |          X                                               X        X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Transitional Epithelium, Carcinoma   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                 X     X                 X        X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Adventitia, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                 X        X  X  X               |         11 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Schwannoma Malignant                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                           X        X                     |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                           X        X  X                  |          6 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                           X                              |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               | X           X  X  X  X     X  X           X     X        X               |         25 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Adenoma                      |             X                                X                           |          6 |
      C-Cell, Carcinoma                    |       X                                         X                        |          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Adenoma                              |                                                          X               |          7 |
      Carcinoma                            |             X                          X                                 |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |       X                 X                                                |          4 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mediastinal, Leukemia Mononuclear    |                                           X                              |          2 |
      Pancreatic, Leukemia Mononuclear     |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +               |  46        |
      Leukemia Mononuclear                 |                                                    X     X               |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                           X           X                  |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                 X        X  X  X               |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  M               |  40        |
      Thymoma Benign                       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                X                    X  X        X                        |         16 |
      Fibroadenoma, Multiple               |    X                                                     X               |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibroma         |                               X  X           X                           |          3 |
      Subcutaneous Tissue, Lipoma          |                                                          X               |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |          1 |
      Carcinoma, Metastatic                |                                                 X                        |          1 |
      Leukemia Mononuclear                 |                                           X        X     X               |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                       +                           |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                 X        X  X  X               |         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X  X  X                 X  X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                 +                       +|             
      Squamous Cell Papilloma              |                                                 X                       X|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                    X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                    X         |             
      Pheochromocytoma Benign              |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                  X           X  X     X     X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                             X            |             
      Follicular Cell, Carcinoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X        X  X     X  X      |             
      Carcinoma                            |                               X           X        X     X     X         |             
      Bilateral, Adenoma                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                     X           X                       X|             
      Polyp Stromal, Multiple              |                                           X                              |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                    X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X  X  X                 X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  +  M  +  M  M  M  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Adenocarcinoma                       |                                                                      X   |             
      Adenoma                              |                                                                   X      |             
      Fibroadenoma                         |                                        X                          X      |             
      Fibroadenoma, Multiple               |                                  X           X     X                     |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                   X      |             
      Basal Cell Adenoma, Multiple         |                                                 X                        |             
      Basal Cell Carcinoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                     +     +     +        +               |             
      Carcinoma, Metastatic, Clitoral Gland|                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Clitoral Gland|                                                          X               |             
      Leukemia Mononuclear                 |                                        X  X                    X         |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                    +                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Renal Tubule, Adenocarcinoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X  X  X                 X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Adenomatous                    |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X  X        X  X  X                 X     X                           |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                  +                                       |   1        |
      Squamous Cell Papilloma              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X                                      X                           |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X                                      X                           |          5 |
      Pheochromocytoma Benign              |             X     X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
      Pars Distalis, Adenoma               | X                 X     X     X     X  X     X  X  X  X  X               |         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      C-Cell, Adenoma                      |                X                                                         |          2 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                     X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +               |  32        |
      Adenoma                              |                            X     X  X  X                                 |          9 |
      Carcinoma                            | X           X  X                                      X                  |          9 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
      Polyp Stromal                        |       X                                X        X                        |          6 |
      Polyp Stromal, Multiple              | X                                                                        |          2 |
      Sarcoma Stromal                      | X                    X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Mediastinal, Leukemia Mononuclear    |       X              X                                                   |          3 |
      Pancreatic, Leukemia Mononuclear     |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X              X  X                    X                           |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X              X  X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X  X        X  X  X  X              X     X                           |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  30        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Adenoacanthoma                       |          X                                                               |          1 |
      Adenocarcinoma                       |                         X                    X                           |          3 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |    X           X  X           X  X  X           X  X                     |         10 |
      Fibroadenoma, Multiple               |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Basal Cell Adenoma                   |                                  X                                       |          2 |
      Basal Cell Adenoma, Multiple         |                                                                          |          1 |
      Basal Cell Carcinoma                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +  +  +                                    |   7        |
      Carcinoma, Metastatic, Clitoral Gland|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |       X                                      X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Alveolar/Bronchiolar Adenoma         |                      X                                   X               |          2 |
      Carcinoma, Metastatic, Clitoral Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |       X              X  X              X     X                           |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Carcinoma                            |             X     X                       X                              |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
      Renal Tubule, Adenocarcinoma         |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X  X        X  X  X  X              X     X                           |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Liver                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hepatocellular Carcinoma             |             X                                                            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Neoplastic Nodule                    |                                                    X                     |             
      Neoplastic Nodule, Multiple          |                                                       X                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                 +                  |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                        +                          +      |             
      Squamous Cell Carcinoma              |                                                                   X      |             
      Squamous Cell Papilloma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Histiocytic       |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Carcinoma                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               |                                                    X        X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                              X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                     X              X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Leukemia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adenoma                              |                                  X              X           X        X   |             
      Carcinoma                            |                                        X     X     X                     |             
      Bilateral, Carcinoma                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Granulosa Cell Tumor NOS             |                               X                                          |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Periovarian Tissue, Sarcoma Stromal, |                                                                          |             
           Metastatic, Uterus              |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Polyp Stromal                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                 +  +  +  +     +  +  +  +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |                                     X                                    |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia                |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                       X                  |             
      Pancreatic, Leukemia                 |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                 X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +                 M  +  +  M     +  +  +  +     +  +  +  +  +|             
      Adenocarcinoma                       |                                                    X  X                 X|             
      Adenoma                              |                                              X                           |             
      Fibroadenoma                         |                                                                          |             
      Fibroadenoma, Multiple               |                                                 X  X  X                  |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                             X            |             
      Basal Cell Carcinoma                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                             X            |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Leukemia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Astrocytoma Malignant                |                                        X                                 |             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                 X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          A        +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                X     X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                   X              X  X  X                                 |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                   X  X        X  X     X                             X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Neoplastic Nodule                    |                            X           X     X  X                 X      |             
      Neoplastic Nodule, Multiple          |                                                             X            |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +     +  +      |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                          X     X  X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                            +                     |             
      Squamous Cell Carcinoma              |       X                                                                  |             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Histiocytic       |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                   X  X        X        X                             X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X        X        X                             X   |             
      Pheochromocytoma Malignant           |                                                             X            |             
      Pheochromocytoma Benign              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X                                                   |             
      Pars Distalis, Adenoma               | X              X  X           X           X                          X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                              X                           |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Leukemia                             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Adenoma                              |                            X  X                       X                  |             
      Carcinoma                            |    X           X  X                                      X        X      |             
      Bilateral, Carcinoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor NOS             |                                                                          |             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Periovarian Tissue, Sarcoma Stromal, |                                                                          |             
           Metastatic, Uterus              |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Polyp Stromal                        |                                  X                       X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia                |             X                                                            |             
      Mediastinal, Leukemia Mononuclear    |                                        X                             X   |             
      Pancreatic, Leukemia                 |             X                                                            |             
      Pancreatic, Leukemia Mononuclear     |                                        X                             X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                   X                                         X        X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                   X              X     X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                   X  X        X  X     X                             X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Adenocarcinoma                       |                                              X     X                     |             
      Adenoma                              |    X                                      X                              |             
      Fibroadenoma                         | X  X                                      X                 X            |             
      Fibroadenoma, Multiple               |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                       X                  |             
      Basal Cell Carcinoma                 |                X                                X                        |             
      Squamous Cell Carcinoma              |                               X                                          |             
      Squamous Cell Papilloma              |                                              X                           |             
      Subcutaneous Tissue, Fibroma         |                                                                X         |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Leukemia                             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Granular Cell Tumor Benign           |                               X                                          |             
      Leukemia Mononuclear                 |                   X                                                  X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X  X                 X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|          X                 X              X                              |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                   X  X                 X                             X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Sarcoma                              |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +           +                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |          X     X        X  X        X  X  X           X     X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |             X                                                            |             
      Leukemia Mononuclear                 |                   X  X        X  X     X                    X        X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hepatocellular Carcinoma             |                                                 X                        |          6 |
      Histiocytic Sarcoma                  |                         X                                                |          1 |
      Leukemia Mononuclear                 |       X        X  X           X              X              X        X   |         16 |
      Lymphoma Malignant Histiocytic       | X                                                                        |          1 |
      Neoplastic Nodule                    |       X                          X           X  X                 X      |         11 |
      Neoplastic Nodule, Multiple          |                   X                 X                                    |          4 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  62        |
      Leukemia Mononuclear                 |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   5        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |             +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma              |             X                                                            |          2 |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
      Peridontal Tissue, Histiocytic       |                                                                          |            |
          Sarcoma                          |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Adenoma                              |                X                                                         |          1 |
      Leukemia Mononuclear                 |                                                                      X   |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                                      X   |          7 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                               X                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  62        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                              X                           |          4 |
      Pars Distalis, Adenoma               | X     X              X  X  X                 X        X     X            |         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                                                     |          2 |
      C-Cell, Carcinoma                    |                X                                                         |          2 |
      Follicular Cell, Adenoma             | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Leukemia                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  62        |
      Adenoma                              |                X        X                       X                        |         10 |
      Carcinoma                            | X                 X           X        X     X  X  X  X              X   |         17 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Carcinoma                 |                                                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Granulosa Cell Tumor NOS             |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Periovarian Tissue, Sarcoma Stromal, |                                                                          |            |
           Metastatic, Uterus              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Adenoma                              |                                                                          |          1 |
      Polyp Stromal                        |          X           X           X              X                        |          7 |
      Polyp Stromal, Multiple              |       X                                                                  |          1 |
      Sarcoma Stromal                      |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma     |                         X                                                |          1 |
      Mediastinal, Leukemia                |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          3 |
      Pancreatic, Leukemia                 |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Histiocytic Sarcoma                  |                         X                                                |          1 |
      Leukemia Mononuclear                 |                X                             X                       X   |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                X              X                                          |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Histiocytic Sarcoma                  |                         X                                                |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X  X           X              X              X        X   |         16 |
      Lymphoma Malignant Histiocytic       | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  59        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  58        |
      Adenocarcinoma                       |                                                       X                  |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                  X                                       |          4 |
      Fibroadenoma                         |                   X           X                                   X  X   |          8 |
      Fibroadenoma, Multiple               |                X                                                         |          4 |
      Sarcoma                              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Basal Cell Adenoma                   |                               X     X                             X      |          5 |
      Basal Cell Carcinoma                 |                                                                          |          2 |
      Squamous Cell Carcinoma              |                                              X  X                        |          3 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                       X                  |          3 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Leukemia                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Alveolar/Bronchiolar Adenoma         |       X           X           X  X                 X                     |          8 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          3 |
      Histiocytic Sarcoma                  |                         X                                                |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                            X        X   |          9 |
      Lymphoma Malignant Histiocytic       | X                                                                        |          1 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +        +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Adenoma                              |                X        X                                                |          2 |
      Carcinoma                            |          X     X     X     X                                   X        X|         17 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                              X                           |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Histiocytic Sarcoma                  |                         X                                                |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X  X           X              X              X        X   |         17 |
      Lymphoma Malignant Histiocytic       | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +           +                 +     +  +  +  +|             
      Adenocarcinoma, Cystic, Mucinous     |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +           +                 M     +  +  +  +|             
      Polyp Adenomatous                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +           +                 +     +  +  +  +|             
      Adenocarcinoma, Cystic, Mucinous     |                                                          X               |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                            +           +                 +     +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                 +              +|             
      Leukemia                             |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            +           +                 +     +  +  +  +|             
      Leukemia                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                            +                                      +      |             
      Leukemia Mononuclear                 |                            X                                             |             
      Squamous Cell Carcinoma              |                                                                   X      |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +           +                 +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +           +                 +     +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                +         |             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +           +                 +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                            +           +                 +     +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                            +           +                 +     +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +           +                 +     +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                            +           +                 +     +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                            +           +                 +     +  +  +  +|             
      Adenoma                              |                                                                X     X   |             
      Carcinoma                            |                                                                         X|             
      Leukemia Mononuclear                 |                            X                                             |             
      Bilateral, Carcinoma                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   |                            +           +                 +     +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  |                            +           +                 +     +  +  +  +|             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +           +                 +     +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +           +                 +     +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
      Iliac, Leukemia Mononuclear          |                            X                                             |             
      Mediastinal, Leukemia                |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                            X                                             |             
      Pancreatic, Leukemia                 |                                                                          |             
      Renal, Leukemia                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            +           +                 +     +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +           +                 +     +  +  +  +|             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  |                            +           +                 +     +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  |                            +           +                 +     +  +  M  +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            +           +                 +     +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                            +           +                 +     +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +           +                 +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                            +           +                 +     +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Basal Cell Carcinoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Carcinoma, Metastatic, Clitoral Gland|                                                                          |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +           +                 +     +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +           +                 +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +           +                 +     +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                                                                X     X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +           +                 +     +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            +           +                 +     +  +  +  +|             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                            +           +                 +     +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenocarcinoma, Cystic, Mucinous     |                                                                          |             
      Polyp Adenomatous                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Cystic, Mucinous     |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                 X              X         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                       X              X   |             
      Neoplastic Nodule                    |                            X  X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                 +           +                       +  +   |             
      Leukemia                             |                               X                                          |             
      Schwannoma Malignant                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |                               X                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                   +                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                 +      |             
      Odontoma                             | X                                                                 X      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                               X                                X         |             
      Follicular Cell, Carcinoma           |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +           +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X     X     X           X                           |             
      Carcinoma                            |          X              X  X           X     X           X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Carcinoma                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Polyp Stromal                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                         X|             
      Iliac, Leukemia Mononuclear          |                                                                      X   |             
      Mediastinal, Leukemia                |                               X                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                       X              X   |             
      Pancreatic, Leukemia                 |                               X                                          |             
      Renal, Leukemia                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +|             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +|             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  +  +  +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenocarcinoma                       |                                     X                                    |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Basal Cell Carcinoma                 |                                           X                              |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                          X               |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +                 +                 +        +  +         |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Oligodendroglioma Malignant          |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                         +|             
      Schwannoma Malignant                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X           X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Basal Cell Carcinoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Carcinoma, Metastatic, Clitoral Gland|                                                          X               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                       +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Pharynx                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenoma                              | X                 X              X                                       |             
      Carcinoma                            |                      X                 X        X                 X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                               X                                          |             
      Leukemia Mononuclear                 |                                                       X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Adenocarcinoma, Cystic, Mucinous     |                X                                                         |          1 |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Adenocarcinoma, Cystic, Mucinous     |                                                                          |          1 |
      Polyp Adenomatous                    |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hepatocellular Carcinoma             |                                              X                           |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          4 |
      Neoplastic Nodule                    | X     X                                      X     X                     |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                +                     |  11        |
      Leukemia                             |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia                             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                   +                                                      |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                   X                                                      |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +        +                              |   4        |
      Squamous Cell Papilloma              |                                  X        X                              |          3 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Odontoma                             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |                      X  X     X                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Adenoma                      |                                                    X                     |          3 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Adenoma                              |       X  X     X           X                                             |         10 |
      Carcinoma                            | X  X                             X        X  X     X                     |         13 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, Carcinoma                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Polyp Stromal                        |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Mediastinal, Leukemia                |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                               X                                          |          4 |
      Pancreatic, Leukemia                 |                                                                          |          1 |
      Renal, Leukemia                      |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  42        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
      Adenocarcinoma                       |                            X                                             |          2 |
      Adenocarcinoma, Multiple             |                         X                                                |          1 |
      Fibroadenoma, Multiple               |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  49        |
      Basal Cell Adenoma                   |       X  X     X                                                         |          3 |
      Basal Cell Carcinoma                 |                                                 X                        |          2 |
      Keratoacanthoma                      |                                  X                                       |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                               X                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +        +  +                                                      |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Pharynx                         |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Oligodendroglioma Malignant          |             X                                                            |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Pharynx                         |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          3 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |    X                                                                     |          1 |
      Basal Cell Carcinoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                 X                        |          1 |
      Carcinoma, Metastatic, Clitoral Gland|                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Pharynx                         |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +              +                                                      |   2        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Pharynx                         |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Adenoma                              |    X                                         X                           |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |          X                    X  X  X  X              X  X               |         13 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Transitional Epithelium, Papilloma   |                                  X                                       |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                             +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                X        X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +  +      |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                             +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Pheochromocytoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                                                             X  X  X      |             
      Bilateral, Pheochromocytoma Benign   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                             +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                                             X     X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                             +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                             +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Bilateral, Carcinoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                                             +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                                                             X  X        X|             
      Interstitial Cell, Adenoma           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +  +  +  +  +|             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                             +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                             +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                X        X|             
      Lipoma                               |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                             M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                             +  +  +  +  +|             
      Fibroadenoma                         |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                             +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Chordoma,       |                                                                          |             
          Metastatic                       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                             +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                             +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                                                             +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X        X|             
      Lymphoma Malignant                   |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Leukemia Mononuclear                 |    X  X  X  X        X        X        X  X     X  X           X     X   |             
      Neoplastic Nodule                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +  +              +                              |             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                  X     X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Carcinoma                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                         X         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                         X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                 X   |             
      Pheochromocytoma Malignant           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |    X  X                       X                          X               |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                         X                     |             
      Pars Distalis, Adenoma               |                X     X                 X  X                 X        X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X                          X                 X                  |             
      C-Cell, Carcinoma                    |                                                             X            |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                         X                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                    X      |             
      Carcinoma                            |                X     X                                                   |             
      Bilateral, Carcinoma                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                         X                                                |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X  X  X  X  X  X   |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X        X                             X           X         |             
      Pancreatic, Leukemia Mononuclear     |          X  X                                                        X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X  X        X                             X           X     X   |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X        X                             X           X     X   |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 |    X  X  X  X        X        X        X  X     X  X           X     X   |             
      Lipoma                               |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                      X                                         X         |             
      Lymphoma Malignant                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Fibroadenoma                         | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                              X                           |             
      Keratoacanthoma                      |                                                                   X      |             
      Squamous Cell Papilloma              |                                                 X                        |             
      Sebaceous Gland, Carcinoma           |                                                    X                     |             
      Subcutaneous Tissue, Chordoma,       |                                                                          |             
          Metastatic                       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                X              X                          X               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X        X        X           X        X           X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                               X   |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X        X        X        X  X     X  X           X     X   |             
      Lymphoma Malignant                   |                                                          X               |             
      Mesothelioma Malignant               |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                            X                                             |          1 |
      Leukemia Mononuclear                 |             X        X  X        X     X     X                           |         20 |
      Neoplastic Nodule                    |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                 +     +     +                 +               |  11        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                            X                                             |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                      X  X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                      X  X                                                |          5 |
      Pheochromocytoma Malignant           |             X                                                            |          2 |
      Pheochromocytoma Benign              | X           X     X     X        X  X  X     X                           |         15 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Adenoma                              |                                     X                                    |          1 |
      Carcinoma                            |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |    X     X                                X                              |         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Adenoma                      |    X                                                                     |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                   X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                    X  X                  |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  44        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                   X                 X                                    |          4 |
      Bilateral, Carcinoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mesothelioma Malignant               |    X                                               X  X                  |          4 |
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X  X  X     X  X  X        X  X  X                     |         37 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Adenoma           |    X        X              X           X  X           X                  |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Iliac, Leukemia Mononuclear          |                         X                                                |          1 |
      Mediastinal, Leukemia Mononuclear    |                      X  X              X                                 |          7 |
      Pancreatic, Leukemia Mononuclear     |                         X              X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                      X  X        X     X                                 |         11 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                      X  X              X                                 |         11 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                            X                                             |          1 |
      Fibrosarcoma                         |                      X                                                   |          1 |
      Leukemia Mononuclear                 |             X        X  X        X     X     X                           |         20 |
      Lipoma                               |                                     X                                    |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +               |  41        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  46        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
      Subcutaneous Tissue, Chordoma,       |                                                                          |            |
          Metastatic                       |                X                                                         |          1 |
      Subcutaneous Tissue, Fibroma         |                                     X                                    |          4 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          4 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Carcinoma       |                X  X                                                      |          2 |
      Fibrosarcoma, Metastatic, Skin       |                                                    X                     |          1 |
      Leukemia Mononuclear                 |             X        X  X        X     X     X                           |         16 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          4 |
      Transitional Epithelium, Carcinoma   |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                    X                     |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X        X     X     X                           |         20 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mesothelioma Malignant               |    X                                               X  X                  |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                X         |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |                               X  X  X        X  X  X  X              X   |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X                           |             
      Neoplasm NOS, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Neoplastic Nodule, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +              +     +     +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X                          X|             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                                  X              X              X         |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pars Distalis, Adenoma               |                                  X                       X     X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                                X         |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X     X                    X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                          X               |             
      Bilateral, Carcinoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X                          X|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Testes                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                              X  X  X                    X|             
      Bilateral, Interstitial Cell, Adenoma|                               X     X  X  X  X  X  X  X  X  X  X  X      |             
      Interstitial Cell, Adenoma           |                                  X                                   X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                      X   |             
      Iliac, Leukemia Mononuclear          |                                                       X                  |             
      Mediastinal, Leukemia Mononuclear    |                                                       X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                               X                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X  X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                       X              X   |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X  X  X        X  X  X  X              X   |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  |                               M  M  +  M  +  M  M  M  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
      Neoplasm NOS                         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                X         |             
      Basal Cell Adenoma, Multiple         |                                                 X                        |             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                                X         |             
      Squamous Cell Carcinoma              |                                                                          |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                        X  X        X                     |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                             X            |             
      Leukemia Mononuclear                 |                               X                    X  X              X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X  X  X        X  X  X  X              X   |             
      Mesothelioma Malignant               |                                              X  X  X                    X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leiomyoma                            |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hepatocellular Carcinoma             |                      X                                                   |          1 |
      Leukemia Mononuclear                 |    X  X  X  X     X  X  X  X        X        X  X  X                     |         20 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                           X                              |          2 |
      Neoplasm NOS, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                    X                     |          1 |
      Neoplastic Nodule, Multiple          |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                    +                              |   6        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X              X                                                      |          3 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X              X                                                      |          3 |
      Pheochromocytoma Benign              |          X     X     X        X  X           X  X                        |         10 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |                   X                 X                                    |          3 |
      Pars Distalis, Adenoma               |                      X  X     X                          X               |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      C-Cell, Adenoma                      |                                  X                                       |          2 |
      C-Cell, Carcinoma                    |                         X                                                |          1 |
      Follicular Cell, Carcinoma           |                                                          X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |       X                                   X                              |          5 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Adenoma                              |    X                                                                     |          1 |
      Carcinoma                            |                                        X                                 |          2 |
      Bilateral, Carcinoma                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Mesothelioma Malignant               |       X                                   X                              |          6 |
      Bilateral, Interstitial Cell, Adenoma|    X  X        X  X  X        X  X  X  X     X     X  X                  |         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Adenoma           | X        X  X           X  X              X     X        X               |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                           X                              |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |    X        X                                                            |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X  X     X        X     X        X                                    |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X  X     X     X  X     X        X                                    |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X  X  X  X     X  X  X  X        X        X  X                        |         19 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  M               |  22        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Neoplasm NOS                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +               |  31        |
      Adenoma                              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Basal Cell Adenoma                   |                                  X                       X               |          3 |
      Basal Cell Adenoma, Multiple         |                                                                          |          1 |
      Basal Cell Carcinoma                 |                                                    X                     |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                  X           X                           |          2 |
      Sebaceous Gland, Adenoma             | X                                                                        |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |             X     X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          2 |
      Leukemia Mononuclear                 |    X  X  X  X     X  X     X        X                                    |         12 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                           X                              |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Leukemia Mononuclear                 |    X  X  X  X     X  X  X  X        X        X  X  X                     |         20 |
      Mesothelioma Malignant               |       X                                   X                              |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Leukemia Mononuclear                 |                               X     X  X     X        X  X     X  X  X   |             
      Neoplastic Nodule                    |                               X                                          |             
      Neoplastic Nodule, Multiple          |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                             +            |             
      Squamous Cell Papilloma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma NOS                       |                                                                          |             
      Endocardium, Schwannoma NOS          |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                               X        X                 X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                        X                 X               |             
      Pheochromocytoma Malignant           |                                                 X                        |             
      Pheochromocytoma Benign              |                                     X                    X  X            |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                           X                              |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                X         |             
      Follicular Cell, Adenoma             |                                                             X            |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
      Carcinoma, Metastatic, Zymbal's Gland|                                           X                              |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                               X  X     X     X  X  X           X  X  X   |             
      Interstitial Cell, Adenoma           |                                     X                 X  X  X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                     X  X                 X        X  X   |             
      Pancreatic, Leukemia Mononuclear     |                                     X                    X        X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X  X              X  X        X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X  X                 X        X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X  X     X           X     X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  M  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                             X            |             
      Basal Cell Adenoma, Multiple         |                               X              X  X        X     X         |             
      Basal Cell Carcinoma                 |                                                                          |             
      Basal Cell Carcinoma, Multiple       |                                                                          |             
      Keratoacanthoma                      |                                  X                                       |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Carcinoma, Multiple    |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Adenoma             |                               X                                          |             
      Sebaceous Gland, Adenoma, Multiple   |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                     X              X                     |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                           X                              |             
      Glioma Malignant                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                                        X              X  X        X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                           X                    X        X|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X  X     X        X  X     X  X  X   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                      X                             X           X         |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Leukemia Mononuclear                 |    X        X  X     X  X  X  X        X                 X        X  X  X|             
      Neoplastic Nodule                    |                                                                   X      |             
      Neoplastic Nodule, Multiple          |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma NOS                       |                                                                          |             
      Endocardium, Schwannoma NOS          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X        X              X                             X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X              X                             X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X  X           X                    X                          X  X      |             
      Bilateral, Pheochromocytoma Benign   |                      X        X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |             X              X                             X               |             
      Pars Distalis, Adenoma               |    X        X     X  X        X  X                 X     X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                X        X                              |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |       X                                   X                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X   |             
      Interstitial Cell, Adenoma           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |             X           X  X           X                             X  X|             
      Pancreatic, Leukemia Mononuclear     |                            X           X                                X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X        X  X  X           X                 X           X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                    X  X                                            X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X     X  X  X  X        X                 X        X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  M  M  +  +  M  +  M  M  +  M  +  M  +  M|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Fibroadenoma                         |                                                             X     X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |    X              X                          X     X              X      |             
      Basal Cell Adenoma, Multiple         | X                    X        X                                X         |             
      Basal Cell Carcinoma                 |                               X                                          |             
      Basal Cell Carcinoma, Multiple       |                                                                          |             
      Keratoacanthoma                      |                               X                                   X      |             
      Squamous Cell Carcinoma              |                               X                          X               |             
      Squamous Cell Carcinoma, Multiple    |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Sebaceous Gland, Adenoma, Multiple   |                                        X                                 |             
      Subcutaneous Tissue, Fibroma         |          X                                         X                     |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Glioma Malignant                     |                                                                          |             
      Leukemia Mononuclear                 |                         X  X           X                             X  X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |             
      Leukemia Mononuclear                 |             X           X  X           X                 X           X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |       X                                                                  |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Skin                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X           X                             X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X     X  X  X  X        X                 X        X  X  X|             
      Mesothelioma Malignant               |                                  X                             X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Hepatocellular Carcinoma             | X              X                                                         |          5 |
      Hepatocellular Carcinoma, Multiple   |                                              X                           |          1 |
      Leukemia Mononuclear                 |       X  X  X  X     X  X  X     X  X     X  X  X  X           X        X|         36 |
      Neoplastic Nodule                    |       X     X                    X           X              X  X         |          8 |
      Neoplastic Nodule, Multiple          |    X     X                                                               |          2 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                         X                                               X|          3 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      Schwannoma NOS                       |                                                 X                        |          1 |
      Endocardium, Schwannoma NOS          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Leukemia Mononuclear                 |          X  X        X                             X           X         |         13 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Leukemia Mononuclear                 |          X  X        X                             X                     |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                               X                    X                     |          3 |
      Pheochromocytoma Benign              | X  X     X        X  X  X        X              X        X        X      |         19 |
      Bilateral, Pheochromocytoma Benign   |             X                                X              X            |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pars Distalis, Adenoma               |             X  X              X                             X        X   |         14 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      C-Cell, Adenoma                      |                                  X              X                        |          6 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                       X  X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   3        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  60        |
      Adenoma                              |                                                          X               |          2 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Mesothelioma Malignant               |       X                                                        X         |          3 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X  X     X  X      |         51 |
      Interstitial Cell, Adenoma           |                      X  X                                               X|          8 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    |                         X                 X           X                  |         14 |
      Pancreatic, Leukemia Mononuclear     |                         X                                               X|          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |                            X        X     X     X     X                 X|         21 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                         X                       X                       X|         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |       X  X  X  X     X  X  X     X  X     X     X  X  X        X        X|         35 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  M  +|  47        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  61        |
      Fibroadenoma                         |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Basal Cell Adenoma                   |          X  X  X  X              X              X                        |         12 |
      Basal Cell Adenoma, Multiple         | X  X                    X                                   X  X         |         14 |
      Basal Cell Carcinoma                 |                                  X                          X            |          3 |
      Basal Cell Carcinoma, Multiple       |                                              X                    X      |          2 |
      Keratoacanthoma                      | X                                                                        |          4 |
      Squamous Cell Carcinoma              |                X                             X     X     X               |          6 |
      Squamous Cell Carcinoma, Multiple    |                                  X                             X         |          2 |
      Squamous Cell Papilloma              |                            X                    X                 X      |          3 |
      Sebaceous Gland, Adenoma             | X                                            X              X            |          4 |
      Sebaceous Gland, Adenoma, Multiple   |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |       X                                                                  |          5 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Glioma Malignant                     |                                                                      X   |          1 |
      Leukemia Mononuclear                 |                                                    X  X                 X|          8 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Alveolar/Bronchiolar Adenoma         |                            X                                             |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |          X           X  X  X        X     X     X  X  X                 X|         22 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  64        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |    X                    X                 X                              |          7 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |                         X                             X                 X|          6 |
      Renal Tubule, Adenoma                |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Leukemia Mononuclear                 |       X  X  X  X     X  X  X     X  X     X  X  X  X  X        X        X|         37 |
      Mesothelioma Malignant               |       X                                                        X         |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                           +              +  +  +  +      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                           +              +  +  +  +      |             
      Adenocarcinoma, Cystic, Mucinous     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                           +              +  +  +  +      |             
      Hepatocellular Carcinoma             |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
      Neoplastic Nodule                    |                                                                          |             
      Neoplastic Nodule, Multiple          |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                           +              +  +  +  +      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                           +              +  +  +  +      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +              +  +  +  +      |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Prostate                                |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                           +              +  +  +  +      |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                                                             X  X  X      |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Testes                          |                                                                          |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           +              M  +  +  M      |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                           +              +  +  +  +      |             
      Basal Cell Adenoma                   |                                                                          |             
      Basal Cell Adenoma, Multiple         |                                                             X  X         |             
      Basal Cell Carcinoma                 |                                                                          |             
      Basal Cell Carcinoma, Multiple       |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Keratoacanthoma, Multiple            |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Squamous Cell Carcinoma              |                                                                   X      |             
      Squamous Cell Carcinoma, Multiple    |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Adenoma             |                                                             X            |             
      Sebaceous Gland, Adenoma, Multiple   |                                                                X  X      |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Sternum, Hemangiosarcoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Mesothelioma Malignant,   |                                                                          |             
           Metastatic, Testes              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                           +              +  +  +  +      |             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                           +              +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    |                                           +              +  +  +  +      |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                           +              +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +              +  +  +  +      |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                                           +              +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Cystic, Mucinous     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |       X                                   X        X                     |             
      Leukemia Mononuclear                 |    X  X        X                    X     X              X               |             
      Neoplastic Nodule                    |                   X     X        X  X           X              X         |             
      Neoplastic Nodule, Multiple          | X              X                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                  X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                  X               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                    +                             +      |             
      Squamous Cell Papilloma              |                X                    X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |       X                             X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |       X        X           X  X  X              X                        |             
      Bilateral, Pheochromocytoma Benign   | X                 X                 X                       X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Pars Distalis, Adenoma               |             X                          X                 X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |       X           X                 X                                    |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |          X     X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                    X              X      |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X  X  X  X  X  X  X     X     X  X            |             
      Interstitial Cell, Adenoma           |                                                 X              X     X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Testes                          |                                                                   X      |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X  X                                   X              X               |             
      Pancreatic, Leukemia Mononuclear     |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X                                         X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X                                         X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X     X              X     X              X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  M  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |    X                 X     X                 X                          X|             
      Basal Cell Adenoma, Multiple         | X              X  X     X     X  X  X              X        X            |             
      Basal Cell Carcinoma                 | X                                            X  X                       X|             
      Basal Cell Carcinoma, Multiple       |                   X                                                      |             
      Keratoacanthoma                      |                               X                             X  X         |             
      Keratoacanthoma, Multiple            |                X                                                         |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Squamous Cell Carcinoma              |       X  X                                                               |             
      Squamous Cell Carcinoma, Multiple    |                                                                          |             
      Squamous Cell Papilloma              |                               X  X                                       |             
      Sebaceous Gland, Adenoma             |                               X                                          |             
      Sebaceous Gland, Adenoma, Multiple   |                                                                          |             
      Sebaceous Gland, Carcinoma           |       X                                                                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                       +                  |             
      Sternum, Hemangiosarcoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Diaphragm, Mesothelioma Malignant,   |                                                                          |             
           Metastatic, Testes              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                       X                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X              X                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |    X  X                             X     X              X               |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            | X  X                       X                                   X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                             X                    X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X     X              X     X              X               |             
      Lymphoma Malignant                   |                                                                          |             
      Mesothelioma Malignant               |                                                    X              X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     A      |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Adenocarcinoma, Cystic, Mucinous     |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hepatocellular Carcinoma             |                      X              X           X                        |          7 |
      Leukemia Mononuclear                 | X  X     X        X                                   X                  |         11 |
      Neoplastic Nodule                    | X           X  X     X              X        X                           |         12 |
      Neoplastic Nodule, Multiple          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                          +                        |   6        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
      Squamous Cell Papilloma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     A      |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |    X     X                                            X                  |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |    X     X                                            X                  |          4 |
      Pheochromocytoma Malignant           |                                                    X                     |          2 |
      Pheochromocytoma Benign              | X              X     X        X     X        X           X               |         13 |
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  47        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
      Pars Distalis, Adenoma               |                                        X                                 |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      C-Cell, Adenoma                      |                                                                          |          3 |
      C-Cell, Carcinoma                    |                                  X                                       |          1 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                   +                        |   3        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  48        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                         X                 X                              |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  48        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  85                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     A      |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mesothelioma Malignant               |             X                                                            |          3 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X  X  X  X     X  X  X     X  X  X  X  X  X               |         38 |
      Interstitial Cell, Adenoma           |          X                             X                                 |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
      Axillary, Leukemia Mononuclear       |    X                                                                     |          1 |
      Axillary, Lymphoma Malignant         |                                              X                           |          1 |
      Mediastinal, Leukemia Mononuclear    |    X                                                                     |          5 |
      Pancreatic, Leukemia Mononuclear     |    X                                                  X                  |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |    X     X        X                                   X                  |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |    X     X                                            X                  |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 | X  X     X        X                                   X                  |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  +  +               |  40        |
      Leukemia Mononuclear                 |    X     X                                                               |          4 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +  +               |  37        |
      Fibroadenoma                         |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Basal Cell Adenoma                   | X        X        X  X  X                 X                              |         11 |
      Basal Cell Adenoma, Multiple         |    X           X              X  X  X  X     X           X               |         19 |
      Basal Cell Carcinoma                 |                                                       X                  |          5 |
      Basal Cell Carcinoma, Multiple       |                                                                          |          1 |
      Keratoacanthoma                      |       X                                         X                        |          5 |
      Keratoacanthoma, Multiple            |          X                                                               |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |       X                                                                  |          1 |
      Squamous Cell Carcinoma              |                X                       X                 X               |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  86                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     A      |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma, Multiple    |             X                                                            |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Sebaceous Gland, Adenoma             |             X                                                            |          3 |
      Sebaceous Gland, Adenoma, Multiple   |                                                                          |          2 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                  X                                       |          1 |
      Subcutaneous Tissue, Lipoma          |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +                                          |   2        |
      Sternum, Hemangiosarcoma             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Mesothelioma Malignant,   |                                                                          |            |
           Metastatic, Testes              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |    X     X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                            +                                             |   1        |
      Schwannoma Malignant                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Leukemia Mononuclear                 | X  X     X        X                                   X                  |         10 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |       X                                                                  |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  87                                                               
NTP Experiment-Test: 05163-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/09/97  
Route: DOSED WATER                                                                                                Time: 14:01:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     A      |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Adenoma                              |          X                                                               |          1 |
      Carcinoma                            |                                        X        X                        |          6 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |    X                                                  X                  |          5 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 | X  X     X        X                                   X                  |         12 |
      Lymphoma Malignant                   |                                              X                           |          1 |
      Mesothelioma Malignant               |             X                                                            |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  88                                                               
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