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TDMS Study 05163-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         C. I. ACID RED 114


NTP Experiment-Test: 05163-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: DOSED WATER                                                                                                Time: 21:51:44




       Facility:  Hazleton Laboratories America, Inc.

       Chemical CAS #:  6459-94-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           45           75           70                                     
  Scheduled Sacrifice                                 20           10           10           20                                     
  Early Deaths                                                                                                                      
    Dead                                               4            6           17           13                                     
    Moribund                                          10           16           41           37                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           13            6                                                  
  Animals Examined Microscopically                    50           35           65           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (35)         (64)         (50)                                   
   Intestine Large, Cecum                             (50)         (35)         (63)         (49)                                   
   Intestine Large, Colon                             (50)         (35)         (63)         (48)                                   
      Adenocarcinoma, Cystic, Mucinous                                                        1 (2%)                                
      Polyp Adenomatous                                             1 (3%)                    1 (2%)                                
   Intestine Large, Rectum                            (50)         (35)         (64)         (49)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Duodenum                          (50)         (35)         (63)         (50)                                   
      Adenocarcinoma, Cystic, Mucinous                                                        1 (2%)                                
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Ileum                             (50)         (35)         (63)         (50)                                   
   Intestine Small, Jejunum                           (50)         (35)         (63)         (50)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Liver                                              (50)         (35)         (64)         (50)                                   
      Hepatocellular Carcinoma                                                   6 (9%)       3 (6%)                                
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Neoplastic Nodule                                                         11 (17%)      6 (12%)                               
      Neoplastic Nodule, Multiple                                                4 (6%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Mesentery                                          (4)          (1)          (4)          (11)                                   
      Schwannoma Malignant                                                                    1 (9%)                                
   Pancreas                                           (50)         (35)         (62)         (50)                                   
   Pharynx                                                         (1)          (5)          (4)                                    
      Squamous Cell Carcinoma                                                    1 (20%)      2 (50%)                               
      Squamous Cell Papilloma                                       1 (100%)     4 (80%)      1 (25%)                               
   Salivary Glands                                    (48)         (35)         (64)         (50)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (35)         (64)         (50)                                   
      Sarcoma                                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (35)         (64)         (50)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Tongue                                                          (2)          (4)          (4)                                    
      Squamous Cell Carcinoma                                                    2 (50%)                                            
      Squamous Cell Papilloma                                       2 (100%)     2 (50%)      3 (75%)                               
   Tooth                                                           (1)          (1)          (2)                                    
      Odontoma                                                                                2 (100%)                              
      Peridontal Tissue, Histiocytic Sarcoma                                     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (35)         (64)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (35)         (64)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (35)         (64)         (50)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)       3 (9%)       4 (6%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (35)         (63)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (50)         (35)         (64)         (49)                                   
      Pars Distalis, Adenoma                          25 (50%)     17 (49%)     17 (27%)      5 (10%)                               
   Thyroid Gland                                      (50)         (35)         (64)         (50)                                   
      C-Cell, Adenoma                                  6 (12%)      2 (6%)       2 (3%)       3 (6%)                                
      C-Cell, Carcinoma                                6 (12%)                   2 (3%)                                             
      Follicular Cell, Adenoma                                      1 (3%)       3 (5%)                                             
      Follicular Cell, Carcinoma                                    2 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (32)         (62)         (50)                                   
      Adenoma                                          7 (15%)      9 (28%)     10 (16%)     10 (20%)                               
      Carcinoma                                        4 (8%)       9 (28%)     17 (27%)     13 (26%)                               
      Bilateral, Adenoma                                            1 (3%)                                                          
      Bilateral, Carcinoma                                                       2 (3%)       2 (4%)                                
   Ovary                                              (50)         (35)         (64)         (49)                                   
      Granulosa Cell Tumor NOS                                                   1 (2%)                                             
      Periovarian Tissue, Sarcoma Stromal,                                                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
          Metastatic, Uterus                                                     1 (2%)                                             
   Uterus                                             (50)         (35)         (64)         (49)                                   
      Adenoma                                                                    1 (2%)                                             
      Polyp Stromal                                    4 (8%)       6 (17%)      7 (11%)      2 (4%)                                
      Polyp Stromal, Multiple                                       2 (6%)       1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)       2 (6%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (35)         (63)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (50)         (35)         (64)         (49)                                   
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                                               1 (2%)                                
      Mediastinal, Histiocytic Sarcoma                                           1 (2%)                                             
   Lymph Node, Mandibular                             (46)         (35)         (64)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (35)         (64)         (48)                                   
   Spleen                                             (50)         (35)         (63)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Thymus                                             (40)         (30)         (59)         (42)                                   
      Thymoma Benign                                   1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (35)         (58)         (45)                                   
      Adenoacanthoma                                                1 (3%)                                                          
      Adenocarcinoma                                                3 (9%)       6 (10%)      2 (4%)                                
      Adenocarcinoma, Multiple                                                                1 (2%)                                
      Adenoma                                          1 (2%)       1 (3%)       4 (7%)                                             
      Fibroadenoma                                    16 (33%)     10 (29%)      8 (14%)                                            
      Fibroadenoma, Multiple                           3 (6%)       3 (9%)       4 (7%)       1 (2%)                                
      Sarcoma                                                                    1 (2%)                                             
   Skin                                               (50)         (35)         (65)         (49)                                   
      Basal Cell Adenoma                                            2 (6%)       5 (8%)       3 (6%)                                
      Basal Cell Adenoma, Multiple                                  1 (3%)                                                          
      Basal Cell Carcinoma                                          1 (3%)       2 (3%)       2 (4%)                                
      Keratoacanthoma                                                                         1 (2%)                                
      Squamous Cell Carcinoma                                                    3 (5%)                                             
      Squamous Cell Papilloma                                                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     3 (6%)                    3 (5%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (3)          (7)                       (10)                                   
      Carcinoma, Metastatic, Clitoral Gland                         1 (14%)                                                         
      Squamous Cell Carcinoma, Metastatic, Pharynx                                            1 (10%)                               
   Skeletal Muscle                                                              (1)          (1)                                    
      Adenocarcinoma, Metastatic, Mammary Gland                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (35)         (64)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Granular Cell Tumor Benign                                                 1 (2%)                                             
      Oligodendroglioma Malignant                                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Pharynx                                            1 (2%)                                
   Peripheral Nerve                                                                          (1)                                    
      Schwannoma Malignant                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (35)         (65)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (6%)       8 (12%)      3 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Basal Cell Carcinoma, Metastatic, Skin                                                  1 (2%)                                
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Carcinoma, Metastatic, Clitoral Gland                         1 (3%)                    1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                      3 (5%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Nose                                               (50)         (35)         (63)         (49)                                   
      Squamous Cell Carcinoma, Metastatic, Pharynx                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                           (2)                                    
      Squamous Cell Carcinoma, Metastatic, Pharynx                                            1 (50%)                               
   Zymbal's Gland                                     (50)         (35)         (63)         (49)                                   
      Adenoma                                                                    2 (3%)       6 (12%)                               
      Carcinoma                                                     3 (9%)      17 (27%)     13 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (35)         (64)         (50)                                   
      Renal Tubule, Adenocarcinoma                                  1 (3%)                                                          
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (49)         (35)         (64)         (49)                                   
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(35)        *(65)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leukemia                                                                   1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            12 (24%)     13 (37%)     17 (26%)      4 (8%)                                
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          35          61          47                                       
     Total Primary Neoplasms                           96          99         192         105                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          31          50          32                                       
     Total Benign Neoplasms                            70          64         104          54                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          25          52          42                                       
     Total Malignant Neoplasms                         26          35          87          51                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           5           5                                       
     Total Metastatic Neoplasm                          1           2           6           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           45           75           70                                     
  Scheduled Sacrifice                                 19           10           10           20                                     
  Early Deaths                                                                                                                      
    Dead                                              13           11           16           16                                     
    Moribund                                          13            9           23           33                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           15           26            1                                     
    Dead                                               1                                                                            
  Surplus                                              1                                                                            
  Animals Examined Microscopically                    50           35           65           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (35)         (64)         (49)                                   
   Intestine Large, Colon                             (50)         (35)         (64)         (50)                                   
   Intestine Small, Ileum                             (50)         (35)         (64)         (49)                                   
   Intestine Small, Jejunum                           (50)         (35)         (64)         (49)                                   
      Adenocarcinoma, Cystic, Mucinous                                                        1 (2%)                                
      Leiomyoma                                                     1 (3%)                                                          
   Liver                                              (50)         (35)         (65)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Hepatocellular Carcinoma                                      1 (3%)       5 (8%)       7 (14%)                               
      Hepatocellular Carcinoma, Multiple                                         1 (2%)                                             
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (3%)                                                          
      Neoplastic Nodule                                2 (4%)                    8 (12%)     12 (24%)                               
      Neoplastic Nodule, Multiple                                   1 (3%)       2 (3%)       3 (6%)                                
   Mesentery                                          (11)         (6)          (1)          (6)                                    
      Carcinoma, Metastatic, Islets, Pancreatic        1 (9%)                                                                       
   Pancreas                                           (50)         (35)         (64)         (49)                                   
   Pharynx                                                                      (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Salivary Glands                                    (49)         (35)         (64)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (35)         (65)         (50)                                   
   Tongue                                                                                    (3)                                    
      Squamous Cell Papilloma                                                                 2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (35)         (65)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Schwannoma NOS                                                             1 (2%)                                             
      Endocardium, Schwannoma NOS                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (35)         (63)         (50)                                   
      Bilateral, Pheochromocytoma Benign                            1 (3%)                                                          
   Adrenal Gland, Medulla                             (50)         (35)         (63)         (49)                                   
      Pheochromocytoma Malignant                       2 (4%)                    3 (5%)       2 (4%)                                
      Pheochromocytoma Benign                         15 (30%)     10 (29%)     19 (30%)     13 (27%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)       1 (3%)       5 (8%)       7 (14%)                               
   Islets, Pancreatic                                 (50)         (35)         (65)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (3%)                                                          
   Pituitary Gland                                    (50)         (35)         (65)         (47)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Pars Distalis, Adenoma                          12 (24%)      7 (20%)     14 (22%)      4 (9%)                                
   Thyroid Gland                                      (50)         (35)         (65)         (49)                                   
      C-Cell, Adenoma                                  5 (10%)      2 (6%)       6 (9%)       3 (6%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (3%)                    1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)       2 (4%)                                
      Follicular Cell, Carcinoma                       2 (4%)       2 (6%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (3)          (3)                                    
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (33%)                                            
      Schwannoma Malignant, Metastatic, Skin                                     1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (35)         (64)         (50)                                   
   Preputial Gland                                    (44)         (34)         (60)         (48)                                   
      Adenoma                                          2 (5%)       1 (3%)       2 (3%)       1 (2%)                                
      Carcinoma                                        4 (9%)       2 (6%)       3 (5%)       4 (8%)                                
      Bilateral, Carcinoma                             1 (2%)       1 (3%)                                                          
   Prostate                                           (50)         (34)         (64)         (50)                                   
   Seminal Vesicle                                    (49)         (34)         (65)         (48)                                   
   Testes                                             (50)         (35)         (64)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           37 (74%)     24 (69%)     51 (80%)     38 (76%)                               
      Interstitial Cell, Adenoma                       7 (14%)     11 (31%)      8 (13%)      5 (10%)                               
                                                             Page   9                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (35)         (64)         (50)                                   
   Lymph Node                                         (49)         (35)         (65)         (50)                                   
   Lymph Node, Mandibular                             (49)         (35)         (65)         (49)                                   
   Lymph Node, Mesenteric                             (49)         (35)         (64)         (50)                                   
   Spleen                                             (50)         (35)         (64)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Fibrosarcoma                                     1 (2%)                                                                       
      Lipoma                                           1 (2%)                                                                       
   Thymus                                             (41)         (22)         (47)         (40)                                   
      Neoplasm NOS                                                  1 (5%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (31)         (61)         (37)                                   
      Adenoma                                                       1 (3%)                                                          
      Fibroadenoma                                     2 (4%)                    3 (5%)       1 (3%)                                
   Skin                                               (50)         (35)         (65)         (50)                                   
      Basal Cell Adenoma                               1 (2%)       3 (9%)      12 (18%)     11 (22%)                               
      Basal Cell Adenoma, Multiple                                  1 (3%)      14 (22%)     19 (38%)                               
      Basal Cell Carcinoma                                          1 (3%)       3 (5%)       5 (10%)                               
      Basal Cell Carcinoma, Multiple                                             2 (3%)       1 (2%)                                
      Keratoacanthoma                                  1 (2%)       1 (3%)       4 (6%)       5 (10%)                               
      Keratoacanthoma, Multiple                                                               2 (4%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Squamous Cell Carcinoma                                       2 (6%)       6 (9%)       6 (12%)                               
      Squamous Cell Carcinoma, Multiple                                          2 (3%)       1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                    3 (5%)       2 (4%)                                
      Sebaceous Gland, Adenoma                                      1 (3%)       4 (6%)       3 (6%)                                
      Sebaceous Gland, Adenoma, Multiple                                         1 (2%)       2 (4%)                                
      Sebaceous Gland, Carcinoma                       1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Chordoma, Metastatic        1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (8%)       3 (9%)       5 (8%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                                                      (2)                                    
      Sternum, Hemangiosarcoma                                                                1 (50%)                               
   Skeletal Muscle                                                 (1)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (35)         (64)         (50)                                   
      Astrocytoma Malignant                                         1 (3%)                    1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Glioma Malignant                                                           1 (2%)                                             
   Peripheral Nerve                                                                          (1)                                    
      Schwannoma Malignant                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (35)         (65)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (6%)       1 (2%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (3%)                    2 (4%)                                
   Nose                                               (50)         (35)         (65)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Trachea                                            (50)         (35)         (65)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (2)          (1)                                    
   Zymbal's Gland                                     (50)         (35)         (64)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Carcinoma                                                                  7 (11%)      6 (12%)                               
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (35)         (65)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (50)         (34)         (64)         (50)                                   
                                                             Page  11                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(35)        *(65)        *(50)                                   
      Leukemia Mononuclear                            20 (40%)     20 (57%)     37 (57%)     12 (24%)                               
      Lymphoma Malignant                               1 (2%)                                 1 (2%)                                
      Mesothelioma Malignant                           4 (8%)       6 (17%)      4 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05163-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          35          64          49                                       
     Total Primary Neoplasms                          135         110         246         196                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          35          61          45                                       
     Total Benign Neoplasms                            92          71         166         141                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          27          54          42                                       
     Total Malignant Neoplasms                         43          38          78          55                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           7           4           7                                       
     Total Metastatic Neoplasm                         14          23           7          18                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                       1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           2                                                   
     Total Uncertain Neoplasms                                      1           2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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