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TDMS Study 05163-01 Pathology Tables

NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97
Route: DOSED WATER                                                                                                Time: 07:17:36




       Facility:  Hazleton Laboratories America, Inc.

       Chemical CAS #:  6459-94-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                          +  +  +  +  +   |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                          +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                          +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                          +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                             1  1     2   |             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                             1  1     1   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                1         |             
      Centrilobular, Necrosis, Coagulative |                                                          2               |             
      Periportal, Fatty Change             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Necrosis, Focal                 |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                          +  +  +  +  +   |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                          +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                          +  +  +  +  +   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                          +  +  +  +  +   |             
      Cardiomyopathy                       |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                          +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                   2  2   |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                          +  +  +  +  +   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                          +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                          +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                          +  +  +  +  +   |             
      C-Cell, Hyperplasia, Focal           |                                                             2            |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                          +  +  M  +  +   |             
      Hyperplasia, Focal, Glandular        |                                                             3        1   |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                          +  +  +  +  +   |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                                                          +  +  +  +  +   |             
      Hydrometra                           |                                                                          |             
      Cervix, Cyst                         |                                                                   X      |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                          +  +  +  +  +   |             
      Hyperplasia, Multifocal, Re Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +  +  +  +  +   |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                          +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                          +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                          +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                          +  +  +  +  +   |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                          +  +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                          +  +  +  +  +   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Sternum, Osteopetrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                          +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Brain Stem, Compression              |                                                             2  2  2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                          +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             1            |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
      Interstitium, Inflammation           |                                                                          |             
      Peribronchiolar, Alveolus,           |                                                                          |             
          Inflammation, Acute              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                          +  +  +  +  +   |             
      Fungus                               |                                                                      2   |             
      Inflammation, Suppurative            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                          +  +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 3| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +  +  +  +  +   |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal, Glandular        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                          +  +  +  +  +   |             
      Nephropathy                          |                                                             3  2  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                          +  +  +  +  +   |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1  1  2        2  2     2     2     2  2  1  1  1  1  1  1  1  2  1     2|             
      Clear Cell Focus                     |                                        1                                 |             
      Fatty Change, Focal                  |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X  X                       X                 X                 X|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                1     1     1     2                          1  1        1|             
      Mixed Cell Focus                     | 1              3                                                         |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Bile Duct, Hyperplasia               |    2                                         2  2           2            |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Periportal, Fatty Change             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +     +                                                   |             
      Fat, Necrosis, Focal                 |                4     3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            2     1           3                    2  2  1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                   2  2        2              1                           |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                   3      |             
      Vacuolization Cytoplasmic, Focal     |                                           2                              |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                          3  2            |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                               2         |             
      Cyst                                 |             X  X                                   X  X     X        X   |             
      Hemorrhage                           |                         3                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                2                 2                                       |             
      Follicular Cell, Hyperplasia, Focal  |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                         2                                                |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                             2            |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal, Re Cell     |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mediastinal, Hemorrhage              |             2  2           2  2        2                       2        2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |             3                                                            |             
      Hemorrhage                           |                                                       2                  |             
      Hyperplasia, Plasma Cell             |    2              2     2        2              2              2        2|             
      Sinus, Ectasia                       |                                                                2        2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Epithelial Cell, Hyperplasia         | 2  2  2        2        2  2  2  2  2     2  2           2  2     2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          2               |             
      Duct, Ectasia                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +                                         +|             
      Sternum, Osteopetrosis               |                               4                                         3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          3               |             
      Brain Stem, Compression              |                   2           2     2     3                             3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Infiltration Cellular, Histiocyte    | 1     1              1     1        1  1  1  1        1  1              1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             2        2                             1                     |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
      Interstitium, Inflammation           |                      1                                                   |             
      Peribronchiolar, Alveolus,           |                                                                          |             
          Inflammation, Acute              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |          4                                                               |             
      Inflammation, Suppurative            |          3                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 8| 0| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 8| 6| 6|             
                                           | 3| 4| 5| 9| 5| 4| 4| 4| 4| 7| 4| 4| 4| 4| 1| 4| 4| 4| 1| 3| 4| 4| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                              3                           |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal, Glandular        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  1  2  1  2  3  2  2  1  2  2  2  2  2  3  1  2  1  2  2  2  1  1  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Artery, Inflammation, Chronic        |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |          2                                                               |      1  2.0|
      Basophilic Focus                     | 1  1  2  2  1  1  1     1     1     1  1     1  1  2  2  2               |     38  1.4|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Fatty Change, Focal                  |                1                                                         |      1  1.0|
      Hepatodiaphragmatic Nodule           | X        X                          X           X                        |      9     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 2  1  1  1  2  1     1        1  1           1  1     2                  |     22  1.2|
      Mixed Cell Focus                     |                                                                          |      2  2.0|
      Necrosis, Coagulative, Multifocal    |                            3                                             |      1  3.0|
      Bile Duct, Hyperplasia               |    2                    2        2              2  2                     |     10  1.9|
      Centrilobular, Necrosis, Coagulative |                                                                          |      1  2.0|
      Periportal, Fatty Change             |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   4        |
      Fat, Necrosis, Focal                 |             3                                                            |      4  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Acinus, Atrophy                      |       2              2           2                       1               |     10  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia                          |                            4                                             |      1  4.0|
      Inflammation, Chronic                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mineralization                       |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |                   1        2              2  1                           |      8  1.6|
      Mineralization                       |                            2                                             |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |                            4        2  2                                 |      4  2.5|
      Necrosis, Multifocal                 |                            3                                             |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      3  2.0|
      Vacuolization Cytoplasmic, Multifocal|                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Focal                   |          2                       2     3                                 |      5  2.4|
      Hyperplasia, Multifocal              |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |    2     2              3        2                                       |      6  2.3|
      Cyst                                 | X        X                             X           X                     |     10     |
      Hemorrhage                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Hyperplasia, Focal           |                               2                                          |      4  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Hyperplasia, Focal, Glandular        |       2                                                                  |      4  2.0|
      Hyperplasia, Focal, Squamous         |    2                                                                     |      1  2.0|
      Duct, Ectasia                        |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Periovarian Tissue, Cyst             |             X                                                            |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hydrometra                           |                                  3                                       |      2  2.5|
      Cervix, Cyst                         |    X                                                                     |      2     |
      Cervix, Inflammation, Suppurative    |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Cyst                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hyperplasia, Multifocal, Re Cell     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Iliac, Hyperplasia, Plasma Cell      |                                        3                                 |      1  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                        3                                 |      1  3.0|
      Mediastinal, Hemorrhage              | 2                          3                 2                           |     10  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +               |  46        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |             2                                                            |      2  2.0|
      Hyperplasia, Plasma Cell             | 2                                      3                                 |      9  2.1|
      Sinus, Ectasia                       |                         2        2              2        2               |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hemorrhage                           |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hematopoietic Cell Proliferation     |                                        3                                 |      3  3.3|
      Inflammation, Granulomatous          | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  M               |  40        |
      Epithelial Cell, Hyperplasia         |    2     2  2  2     2        2     2  2     2  2     2                  |     25  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Duct, Ectasia                        |             2  2  3        4                                             |      6  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +                                                         |   3        |
      Sternum, Osteopetrosis               |                3                                                         |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Brain Stem, Compression              |             3        1        3                          2               |     12  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3|              |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                     1                                    |     13  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       2                                                  2               |      6  1.7|
      Bronchiole, Inflammation, Acute      |                            3                                             |      1  3.0|
      Interstitium, Inflammation           |                                                                          |      1  1.0|
      Peribronchiolar, Alveolus,           |                                                                          |            |
          Inflammation, Acute              |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Fungus                               |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                            2              2                              |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Inflammation, Suppurative            |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                       +                           |   3        |
      Cataract                             |                      2                       3                           |      3  2.7|
      Retina, Degeneration                 |                      3                       3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ectasia                              |                                                    4                     |      1  4.0|
      Hyperplasia, Focal, Glandular        |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Nephropathy                          | 1  1  2  2  3  3  3  2  1  4  2  2     1  1  2  1  1  2  2               |     48  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hyperplasia, Focal                   |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   3      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                               2  1           3     2     2  2     3  2  1|             
      Degeneration, Cystic                 |                                              2                 3         |             
      Eosinophilic Focus                   |                               1              2  2        2  4  2  3     1|             
      Fatty Change, Multifocal             |                                                                          |             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                               1                 1        1        1  1   |             
      Hepatodiaphragmatic Nodule           |                                                    X                     |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                               1                                          |             
      Mixed Cell Focus                     |                                  2           3        2              2   |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |                                                 2     2              2   |             
      Centrilobular, Fatty Change          |                                                                   2      |             
      Centrilobular, Necrosis, Coagulative |                                                                   2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                          2     2         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                 +                       +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                               2  1                                       |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                     3                             3      |             
      Valve, Inflammation, Chronic Active  |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2              2           2        2      |             
      Atrophy                              |                                                                      4   |             
      Necrosis, Focal                      |                                                                   1      |             
      Necrosis, Multifocal                 |                                     2                                    |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                  2                                       |             
      Vacuolization Cytoplasmic, Multifocal|                                     2  2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               1           2           2  1               |             
      Hyperplasia, Multifocal              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                        X                 X     X     X   |             
      Pars Distalis, Hyperplasia, Focal    |                               2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                               2                                2         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Duct, Ectasia                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitium, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydrometra                           |                                              2                           |             
      Cervix, Cyst                         |                                                             X            |             
      Endometrium, Cyst                    |                                                             X            |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                 2        2  2            |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Plasma Cell             |                                              3           2           3   |             
      Sinus, Ectasia                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                               3                          4        3  3   |             
      Hyperplasia, Focal, Re Cell          |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  +  M  +  M  M  M  M  +  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                               2  2                       2  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Duct, Ectasia                        |                               3                       2           3      |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
          Cell, Focal                      |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                     +     +     +        +               |             
      Cranium, Fibrous Osteodystrophy      |                                                 3                        |             
      Sternum, Fibrous Osteodystrophy      |                                                 2                        |             
      Sternum, Osteopetrosis               |                                     3     2                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                                 |             
      Brain Stem, Compression              |                                  2              2     3                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 5| 5|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 7| 6| 8| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 6| 8| 7| 3| 3| 3| 8| 8| 4| 7| 3| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.015                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Edema                                |                                                          3               |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               1  1           1  1  1        1     1  1  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                               1                    2     2               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                   2      |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                       1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                    +                     |             
      Cataract                             |                               2                    3                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change                         |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          |                                  2  2  1  2  1  4  1  3     2  2  1  1  1|             
      Pigmentation                         |                                                                          |             
      Interstitial Tissue, Fibrosis, Focal |                                              2                           |             
      Interstitial Tissue, Inflammation    |                                              3                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Acute                  |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Parasite Metazoan                    |    1                       2                                             |      3  1.7|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Angiectasis                          |                2                                2     2                  |      3  2.0|
      Basophilic Focus                     | 2  2        1     2        2  2  2  1           2     1  1               |     20  1.8|
      Degeneration, Cystic                 |                      2  2                          2                     |      5  2.2|
      Eosinophilic Focus                   |                3  2        2        1                                    |     12  2.1|
      Fatty Change, Multifocal             |                                                    2                     |      1  2.0|
      Hematocyst                           |                                  X                                       |      1     |
      Hematopoietic Cell Proliferation     |             1              1                                             |      7  1.0|
      Hepatodiaphragmatic Nodule           |    X                       X                                             |      3     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                               1  1              2  1     1               |      6  1.2|
      Mixed Cell Focus                     | 2  2                          2     1                 1                  |      9  1.9|
      Necrosis, Coagulative, Multifocal    |                   2                                                      |      1  2.0|
      Regeneration                         |                                        3     3                           |      2  3.0|
      Bile Duct, Hyperplasia               |    2              2              2  1                                    |      7  1.9|
      Centrilobular, Fatty Change          |                                           1     2                        |      3  1.7|
      Centrilobular, Necrosis, Coagulative |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
      Inflammation, Chronic                |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Acinus, Atrophy                      |                                  2                    1                  |      4  1.8|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Inflammation, Acute                  |                                              3     2                     |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                  +                                       |   1        |
      Peridontal Tissue, Hyperplasia       |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Cardiomyopathy                       |                                        2  2           1                  |      5  1.6|
      Atrium, Dilatation                   |          4                                                               |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      2  3.0|
      Valve, Inflammation, Chronic Active  |                            4                                             |      1  4.0|
      Valve, Thrombosis                    |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Angiectasis                          |                                  2                                       |      5  2.0|
      Atrophy                              |                                                                          |      1  4.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                         3                                                |      1  3.0|
      Vacuolization Cytoplasmic, Focal     | 2  2                          2                                          |      4  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hyperplasia, Focal                   | 1                                                                        |      5  1.4|
      Hyperplasia, Multifocal              |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Angiectasis                          |                3                 2                                       |      2  2.5|
      Cyst                                 |    X                    X  X  X                                          |      8     |
      Pars Distalis, Hyperplasia, Focal    |          2     2                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      C-Cell, Hyperplasia, Focal           |                               1                                          |      3  1.7|
      Follicle, Cyst                       | X                                                                        |      1     |
      Follicular Cell, Hyperplasia, Focal  | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +               |  32        |
      Hyperplasia, Focal, Glandular        |    2                                   2                                 |      2  2.0|
      Duct, Ectasia                        |       3                                                  3               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Interstitium, Cyst                   |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrometra                           |                                                                          |      1  2.0|
      Cervix, Cyst                         |                                                                          |      1     |
      Endometrium, Cyst                    |                                        X                                 |      2     |
      Endometrium, Hyperplasia             |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Myelofibrosis                        |                                        2                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Mediastinal, Hemorrhage              |                      3                    2     2        2               |      7  2.1|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |             2                                                            |      2  2.0|
      Hyperplasia, Plasma Cell             |             2              3  2  2     3  3                              |      9  2.6|
      Sinus, Ectasia                       | 2           4  2  2                                2                     |      6  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Fibrosis                             |                                        3                                 |      1  3.0|
      Hematopoietic Cell Proliferation     |          3  4              4              3                              |      8  3.4|
      Hyperplasia, Focal, Re Cell          |                                                          2               |      1  2.0|
      Pigmentation, Hemosiderin            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  30        |
      Epithelial Cell, Hyperplasia         | 2     2        2     2  2  2  2  2  2  2  2        2  2                  |     20  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Galactocele                          |                                                          X               |      1     |
      Duct, Ectasia                        |                               3                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hair Follicle, Hyperplasia, Basal    |                                                                          |            |
          Cell, Focal                      |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +  +  +                                    |   7        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1  3.0|
      Sternum, Fibrous Osteodystrophy      |                                                                          |      1  2.0|
      Sternum, Osteopetrosis               |                               2  2  2                                    |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |       3                                      1                           |      3  1.7|
      Brain Stem, Compression              | 2                 2                          2  3  3     3               |      9  2.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Congestion                           |          3                                                               |      2  2.5|
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |          2                 1                                             |      2  1.5|
      Infiltration Cellular, Histiocyte    | 1  1        1     1  1  1  1  1  1        1     1  1  1                  |     22  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                     1              2                     |      5  1.6|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interstitium, Inflammation           |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |             2                                                            |      1  2.0|
      Inflammation, Suppurative            |                                           1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Fatty Change                         |                                           2                              |      1  2.0|
      Fibrosis, Focal                      |                            3                                             |      1  3.0|
      Nephropathy                          | 2  2  2  1  1  2  2  2  2     2  2  2  2  2  3  3  2  1  2               |     32  1.9|
      Pigmentation                         |                                        3                                 |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 4| 6| 6| 6| 5| 4|              |            |
                             DAY ON TEST   | 3| 3| 0| 0| 1| 3| 3| 6| 6| 1| 3| 3| 3| 1| 6| 5| 4| 3| 2| 1|              |            |
                                           | 4| 4| 8| 0| 1| 4| 4| 5| 2| 4| 4| 4| 4| 5| 2| 8| 1| 8| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.015                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Tissue, Fibrosis, Focal |                                                                          |      1  2.0|
      Interstitial Tissue, Inflammation    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    1                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Basophilic Focus                     |             2                 3  2              2  3        3  3     2  1|             
      Congestion                           |                                                                      3   |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                               2                 2  4  3           3  3   |             
      Eosinophilic Focus                   |             2                    3     2        3  2        2     1  2   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |             1                    1           1                           |             
      Hemorrhage                           |                                                       3                  |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                         2|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                               2                 2  3                     |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |                                                 2                        |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                              4                           |             
      Periportal, Fatty Change             |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                 +                  |             
      Fat, Necrosis, Focal                 |                                                       4                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                 +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Acinus, Atrophy                      |                                  1                                       |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                        +                          +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adventitia, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Cardiomyopathy                       |                                                                2         |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                              4                           |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                             3  2         |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Focal                           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                    2                     |             
      Hyperplasia, Multifocal              |                                  1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2  2                        |             
      Congestion                           |                                                          2               |             
      Cyst                                 |             X                 X     X  X              X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                 2                        |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                             3            |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Inflammation, Suppurative            |                                                    2                     |             
      Duct, Ectasia                        |                               3     2                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Decidual Reaction                    |                                                                         3|             
      Hydrometra                           |                                                                          |             
      Endometrium, Cyst                    |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                 +  +  +  +     +  +  +  +     M  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                      3   |             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                 2  2           3     3   |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Adventitia, Inflammation, Chronic    |                                                                          |             
      Sinus, Ectasia                       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |             4                    4           3                          3|             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Capsule, Hemorrhage                  |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         |                               2  2  2        2  2  2           2        2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +                 M  +  +  M     +  +  +  +     +  +  +  +  +|             
      Galactocele                          |                                                       X     X            |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          2               |             
      Ulcer, Multifocal                    |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                     3                          3     3   |             
      Necrosis, Focal                      |                                                                      3   |             
      Meninges, Inflammation, Subacute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +                 +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      4   |             
      Edema                                |                                                                      2   |             
      Hemorrhage                           |                                                          3  2            |             
      Infiltration Cellular, Histiocyte    |             1                          1     1     1  1     1  1  1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2        2  1                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Bronchiole, Foreign Body             |                                                                          |             
      Bronchiole, Inflammation, Acute      |                               3                                          |             
      Interstitium, Inflammation           |                                  1                                       |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Peribronchiolar, Alveolus,           |                                                                          |             
          Inflammation, Acute              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 5| 5| 4| 4| 7| 7| 7| 6| 0| 6| 5| 5| 5| 2|             
                             DAY ON TEST   | 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 1| 2| 1| 8| 6| 3| 3| 3| 7| 8| 9| 7| 7| 3| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 3| 5| 7| 0| 3| 3| 3| 7| 7| 3| 9| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Fungus                               |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Adventitia, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          A        +      |             
      Cataract                             |                                                                   3      |             
      Inflammation, Chronic                |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Retina, Degeneration                 |                                                                   4      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |             2                                                            |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |             1                 2  1  2  1     2  3  3  2     3  2  3  3   |             
      Pigmentation                         |                                                                          |             
      Interstitial Tissue, Inflammation    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                 +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    2                             2                             2  1      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                          2|             
      Basophilic Focus                     |    2     2     2     3     2  4  2  3  3  4        3  2  2  2  2  2     2|             
      Congestion                           |                                                                          |             
      Cyst                                 |                   X                                                      |             
      Degeneration, Cystic                 | 3                    2           2        2  2  2  2  2     3     2     1|             
      Eosinophilic Focus                   | 3  2  2  2           2  2  2  2  3  2  3  2           2     2  4  2     1|             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |          1     2              2           1                              |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |    1                          1     1        2        2  1        1      |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |    1                                                        1            |             
      Mixed Cell Focus                     |                                           4                 3  2         |             
      Necrosis, Coagulative, Multifocal    | 2                                                                        |             
      Necrosis, Focal                      |                                                                          |             
      Regeneration                         |                                  3                                       |             
      Bile Duct, Hyperplasia               |                                              2                           |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                              2  4        2               |             
      Periportal, Fatty Change             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis, Focal                 |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2           1  2                                                     2|             
      Acinus, Hyperplasia, Focal           |                                                             2     2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +     +  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adventitia, Inflammation, Chronic    |                3                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
      Inflammation, Acute                  |                                           3                              |             
      Inflammation, Chronic                |                3                                                         |             
      Ulcer                                |             4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 2                        |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                            +                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                               2        3           1  1                  |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   | 3                                                                        |             
      Valve, Thrombosis                    | 3                    1                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                       2                                                |             
      Fibrosis                             |                                                 4                        |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |          4  3                                                            |             
      Vacuolization Cytoplasmic, Focal     | 2                    2                       3           2               |             
      Vacuolization Cytoplasmic, Multifocal|                2                 2                                       |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                2  1           2                 2                    2   |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3                                       |             
      Congestion                           |                                                                          |             
      Cyst                                 |                         X     X  X  X  X     X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicle, Cyst                       |                               X                                          |             
      Follicular Cell, Hyperplasia, Focal  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                             2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                                                          |             
      Hydrometra                           |                                                                          |             
      Endometrium, Cyst                    |                   X  X              X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                 2  2                    2|             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Pancreatic, Hemorrhage               |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                            2|             
      Hyperplasia, Plasma Cell             |    2     3     3        3  3  2  3        3  4              2     2      |             
      Hyperplasia, Re Cell                 |                                                       2                  |             
      Adventitia, Inflammation, Chronic    |                3                                                         |             
      Sinus, Ectasia                       |                               2  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   2      |             
      Hematopoietic Cell Proliferation     |    3                       3                 4  4  4  4  3        4      |             
      Necrosis                             |                                  3                                       |             
      Pigmentation, Hemosiderin            |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Capsule, Hemorrhage                  | 4                                                                        |             
      Red Pulp, Atrophy                    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Epithelial Cell, Hyperplasia         |    2     2  2  2  2           2  2  2        2  2           2  2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                |                3                                                         |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer, Multifocal                    |          4                                                               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2        2                                                  3   |             
      Necrosis, Focal                      |                                                                          |             
      Meninges, Inflammation, Subacute     |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Edema                                |                                                                          |             
      Hemorrhage                           | 4                                                                        |             
      Infiltration Cellular, Histiocyte    |    1           1  1        1           1     1        1     1  1  1     1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                            2  2  2              2     1  2  2     2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                     2                                    |             
      Bronchiole, Foreign Body             |       2                                                                  |             
      Bronchiole, Inflammation, Acute      |       3                                                                  |             
      Interstitium, Inflammation           |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                3                                                         |             
      Peribronchiolar, Alveolus,           |                                                                          |             
          Inflammation, Acute              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 3| 7| 6| 6| 4| 4| 7| 7| 6| 6| 5| 6| 5| 5| 5| 4| 7| 6| 5| 5| 5|             
                             DAY ON TEST   | 8| 9| 3| 1| 4| 0| 4| 0| 4| 0| 3| 1| 4| 3| 3| 1| 8| 3| 2| 9| 1| 4| 9| 8| 4|             
                                           | 0| 2| 0| 7| 4| 9| 9| 9| 8| 3| 3| 5| 1| 1| 8| 4| 1| 1| 1| 6| 5| 1| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Inflammation, Suppurative            |          3     3  1           2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Adventitia, Inflammation, Chronic    |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +           +                                             |             
      Cataract                             |                            2                                             |             
      Inflammation, Chronic                |                4                                                         |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Retina, Degeneration                 |                            2                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Inflammation, Suppurative            |       4                                                                  |             
      Nephropathy                          | 2  2  2  2  1  3  3  2  1  1  2  2  2     2  3  2  2  1  1  3  2  2  2  3|             
      Pigmentation                         |                      3                                                   |             
      Interstitial Tissue, Inflammation    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 4                       4|             
      Hemorrhage                           |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Ulcer                                |                                                                4         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Parasite Metazoan                    |                                     2  3                                 |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  64        |
      Parasite Metazoan                    |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Angiectasis                          |       2        2     2                                                   |      6  2.0|
      Basophilic Focus                     | 3  2        1                       2  3     2  3  2  4     2     2     2|     38  2.4|
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |    X                                                              X      |      3     |
      Degeneration, Cystic                 |    2           2     2        2  2           2                 4  2      |     25  2.3|
      Eosinophilic Focus                   |             2  3     2        2  2  3  3        2  2  2           1  1  1|     38  2.1|
      Fatty Change, Diffuse                |                                                                3        1|      2  2.0|
      Fatty Change, Multifocal             |                                        1                 1               |      6  1.3|
      Fibrosis, Focal                      |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     |          1                       1  1           2                 1      |     15  1.2|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |             X  X           X                                             |      5     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      2  1.0|
      Mixed Cell Focus                     |                                                 1  2                     |      8  2.4|
      Necrosis, Coagulative, Multifocal    |                                                       1                  |      2  1.5|
      Necrosis, Focal                      |                                                 3                        |      1  3.0|
      Regeneration                         |                3                                               2         |      3  2.7|
      Bile Duct, Hyperplasia               |       2                       2                                          |      4  2.0|
      Centrilobular, Fatty Change          |          2                                                               |      1  2.0|
      Centrilobular, Necrosis, Coagulative |          3                 2                                             |      6  2.8|
      Periportal, Fatty Change             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   4        |
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  62        |
      Acinus, Atrophy                      |                   2                                                      |      6  1.7|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Adventitia, Inflammation, Chronic    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                | 3                                                              4         |      3  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Erosion                              |                                                                2         |      3  2.0|
      Mineralization                       |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |             +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Cardiomyopathy                       |                         2                                2  2            |      8  1.9|
      Mineralization                       |                                  1                                       |      1  1.0|
      Atrium, Thrombosis                   | 3                       3                                   3  4         |      6  3.3|
      Valve, Thrombosis                    |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Angiectasis                          |                   2                                2                     |      5  2.2|
      Fibrosis                             |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                             3            |      1  3.0|
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  3.5|
      Vacuolization Cytoplasmic, Focal     |                      2           2  2                 1                  |     10  2.1|
      Vacuolization Cytoplasmic, Multifocal|                   2                                                      |      3  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hyperplasia, Focal                   |                            2        1                 2        3     2   |     11  1.9|
      Hyperplasia, Multifocal              |                   2              2              2                        |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  62        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Angiectasis                          |       2                                                        2         |      5  2.2|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |          X           X        X     X  X        X     X     X  X  X      |     22     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Ultimobranchial Cyst                 |                                                       X                  |      1     |
      C-Cell, Hyperplasia, Focal           |                   2  1                                                   |      3  1.7|
      Follicle, Cyst                       |                            2                                             |      2  2.0|
      Follicular Cell, Hyperplasia, Focal  |          1                    1                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  62        |
      Hyperplasia, Focal, Glandular        |       2        2     2           1                             2  2      |      8  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Duct, Ectasia                        |                      2                                                   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Periovarian Tissue, Cyst             |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Decidual Reaction                    |                                                                          |      1  3.0|
      Hydrometra                           |                      2                                2                  |      2  2.0|
      Endometrium, Cyst                    |                                                                   X      |      5     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Mediastinal, Hemorrhage              |                         3              2                       3         |      7  2.4|
      Mediastinal, Hyperplasia, Re Cell    |                                     3                                    |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |          3  2     2  4     2                    3  2                    3|     23  2.7|
      Hyperplasia, Re Cell                 |                                     2                                    |      2  2.0|
      Adventitia, Inflammation, Chronic    |                                                                          |      1  3.0|
      Sinus, Ectasia                       |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hemorrhage                           |                         2        3                          3            |      4  2.5|
      Hyperplasia, Re Cell                 |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  63        |
      Fibrosis                             |                                                                3         |      2  2.5|
      Hematopoietic Cell Proliferation     |          3                 3        4  4        3     4        4  3      |     20  3.6|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |             3        2                                                  2|      4  2.5|
      Capsule, Hemorrhage                  |                                                                          |      1  4.0|
      Red Pulp, Atrophy                    |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  59        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |       2     2     2        2     2  2                       2     2  2   |     29  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  58        |
      Galactocele                          |                                                                          |      2     |
      Hyperplasia, Nodular                 |    3                                                                     |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                 2           2            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer, Multifocal                    |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hemorrhage                           |                                                                          |      6  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Meninges, Inflammation, Subacute     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Congestion                           |                                                                          |      2  3.5|
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                  2                                       |      4  2.8|
      Infiltration Cellular, Histiocyte    |       1     1     1        1  1     1  1     1  1  1  1        1        1|     32  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       1  1                                                               |     13  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                      1                                                   |      2  1.5|
      Bronchiole, Foreign Body             |                                                                          |      1  2.0|
      Bronchiole, Inflammation, Acute      |                                                                          |      2  3.0|
      Interstitium, Inflammation           |                                                                          |      1  1.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  3.0|
      Peribronchiolar, Alveolus,           |                                                                          |            |
          Inflammation, Acute              |                                                                         2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Fungus                               |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |    3                 2                                   2     2         |      9  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Ectopic Tissue                       |                                                                X         |      1     |
      Adventitia, Inflammation, Chronic    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +        +                                                   |   5        |
      Cataract                             |             3                                                            |      3  2.7|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                      4                                                   |      1  4.0|
      Retina, Degeneration                 |             4                                                            |      3  3.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Hyperplasia, Focal, Glandular        |             3                                                            |      2  2.5|
      Hyperplasia, Focal, Squamous         |                               2              2                    2      |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 4| 7| 6| 6| 5| 5| 7| 6| 5| 4| 0| 7| 7| 5| 5| 4| 6| 6| 5| 5| 4|            |
                             DAY ON TEST   | 7| 5| 5| 4| 5| 3| 9| 3| 9| 8| 3| 9| 5| 7| 5| 1| 1| 8| 6| 9| 4| 3| 9| 9| 9|            |
                                           | 6| 8| 6| 5| 4| 3| 3| 8| 9| 8| 4| 4| 4| 7| 3| 5| 5| 2| 7| 4| 8| 7| 2| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Cyst                                 |                                                                          |      2     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Nephropathy                          | 2  2  2  2  2  2  3  3  1  2  2  4  1  1     3  2  2  2     2  2  2  2  2|     60  2.1|
      Pigmentation                         |                                                                          |      1  3.0|
      Interstitial Tissue, Inflammation    |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Ectasia                              |                                                                          |      2  4.0|
      Hemorrhage                           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +           +                 +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +           +                 +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +           +                 M     +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +           +                 +     +  +  +  +|             
      Parasite Metazoan                    |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                            +           +                 +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                1        1|             
      Eosinophilic Focus                   |                                        2                       2  2  2  2|             
      Fatty Change, Focal                  |                                                                          |             
      Fatty Change, Multifocal             |                                                                          |             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                                                                         2|             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration                         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                        2                          3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                 +              +|             
                                            __________________________________________________________________________|             
   Pancreas                                |                            +           +                 +     +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                            +                                      +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +           +                 +     +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +           +                 +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +           +                 +     +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Edema                                |                                                                          |             
      Erosion                              |                            2           3                          3      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                +         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +           +                 +     +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                            +           +                 +     +  +  +  +|             
      Angiectasis                          |                            3                                   2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Focal                      |                                                          1               |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                2         |             
      Bilateral, Necrosis, Focal           |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                            +           +                 +     +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            +           +                 +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +           +                 +     +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Pigmentation, Hemosiderin            |                                                                2         |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                            +           +                 +     +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                            +           +                 +     +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                            +           +                 +     +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                            +           +                 +     +  +  +  +|             
      Hydrometra                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +           +                 +     +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +           +                 +     +  +  +  +|             
      Iliac, Sinus, Ectasia                |                                        3                                 |             
      Mediastinal, Hemorrhage              |                                                          2              2|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            +           +                 +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                      3   |             
      Sinus, Ectasia                       |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +           +                 +     +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                            +           +                 +     +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        4                                3|             
      Pigmentation, Hemosiderin            |                                                                3         |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                            +           +                 +     +  +  M  +|             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            +           +                 +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                            +           +                 +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Cartilage, Sternum, Degeneration     |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Sternum, Fibrous Osteodystrophy      |                                                                          |             
      Sternum, Osteopetrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +           +                 +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Brain Stem, Compression              |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                            +           +                 +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                        1                 1     1  1  1  1|             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        1                                1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +           +                 +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                   3  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +           +                 +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +           +                 +     +  +  +  +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal, Squamous         |                            2                                             |             
      Hyperplasia, Multifocal, Squamous    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 3| 2| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 6| 6| 6| 6| 1| 6| 2| 7| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 0| 0| 0| 9| 7| 0| 0| 0| 0| 2| 0| 1| 2| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +           +                 +     +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Karyomegaly                          |                                                                          |             
      Nephropathy                          |                            1           1                 2     3  3  2  2|             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            +           +                 +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             1            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 2        4        3     2  3  3  2  2     3  2     1                     |             
      Clear Cell Focus                     |                                                          1               |             
      Degeneration, Cystic                 |                2  1     1  1        1           3                        |             
      Eosinophilic Focus                   | 2        3     3  2  2  2  2  3  3  2  3  3  4  3  2     2  3  2  2  3  2|             
      Fatty Change, Focal                  |                                                          1               |             
      Fatty Change, Multifocal             |                   1                                               1      |             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |          1              1  1                 1           1               |             
      Hepatodiaphragmatic Nodule           | X                                   X                 X  X               |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |             2  2        3  2                       2        2     2      |             
      Necrosis, Coagulative, Multifocal    |          1                    2                                          |             
      Regeneration                         |                               3                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                 +           +                       +  +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                2                                                         |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                   +                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                   3                                                      |             
      Ulcer                                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                     2                                    |             
      Edema                                |                                                                          |             
      Erosion                              |          1                                                               |             
      Mineralization                       |                                  3                          3            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                 +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                  1                                       |             
      Mineralization                       |                                                             2            |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2              2                    3                    2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                3         |             
      Vacuolization Cytoplasmic, Focal     | 2                             2  2  2                       2            |             
      Bilateral, Necrosis, Focal           |                                                                      3   |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Multifocal                      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                          3  3         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                         X|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Cyst                  |                         X                                                |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                     X                       X            |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                    2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                   3           2           3                 4  2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                X                                                         |             
      Periovarian Tissue, Cyst             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hydrometra                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3        3                                                      |             
      Hemorrhage                           |                                                                          |             
      Myelofibrosis                        |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Iliac, Sinus, Ectasia                |                                                                          |             
      Mediastinal, Hemorrhage              | 3                                               2     3     3  2     3   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                2                       2                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 4                    4     2           3        3        2        4      |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                 2                                       |             
      Infiltration Cellular, Mast Cell     |                                  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                3                 3     4                                 |             
      Hematopoietic Cell Proliferation     |          4              4  4              4  4  3        4               |             
      Pigmentation, Hemosiderin            |                      2                                      2            |             
      Red Pulp, Atrophy                    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  +  +  +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  +  +|             
      Ectopic Parathyroid Gland            |                X                                                         |             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         |                2        2  2        2     2              2        2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis, Focal                    |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +                 +                 +        +  +         |             
      Cartilage, Sternum, Degeneration     |                                  3                                       |             
      Cranium, Fibrous Osteodystrophy      |                3                 3                 3        2  3         |             
      Sternum, Fibrous Osteodystrophy      |                                  2                             X         |             
      Sternum, Osteopetrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Brain Stem, Compression              |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                         +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        3                                 |             
      Hemorrhage                           |                                                                      2   |             
      Infiltration Cellular, Histiocyte    | 1        1        1              1  1     1  1  1        1  1  1         |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          1     1  2        1                          2        2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                           1     2           2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      1              2                                    |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                       +   |             
      Necrosis                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                                3         |             
      Hyperplasia, Focal, Squamous         |                                              3                           |             
      Hyperplasia, Multifocal, Squamous    |                         2                                                |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 1| 5| 5| 4| 4| 4| 4| 4| 4| 3| 3| 5| 5| 4| 4| 4| 4| 5| 4| 2| 2|             
                             DAY ON TEST   | 7| 6| 6| 5| 8| 5| 0| 3| 1| 1| 8| 7| 1| 8| 4| 4| 0| 3| 1| 0| 5| 9| 1| 7| 5|             
                                           | 7| 0| 0| 6| 6| 1| 1| 3| 3| 1| 8| 5| 1| 3| 4| 5| 1| 3| 3| 3| 8| 9| 3| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    0.06                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                             1            |             
      Karyomegaly                          | 1                    1  1              1                                 |             
      Nephropathy                          | 3        2     4  4  3  2  3  3  4  4  3  1  3  3  4  2     4  4  4  2  2|             
      Renal Tubule, Hyperplasia, Focal     |                                                             1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hemorrhage                           |                2                                                         |      1  2.0|
      Ulcer                                |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Diverticulum                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |                2              3  2                                       |      3  2.3|
      Basophilic Focus                     |          2        2                          2  2  3     2               |     17  2.4|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Degeneration, Cystic                 |    3  1        2     1                          3     3                  |     14  1.7|
      Eosinophilic Focus                   |    3  3  2  2  3  2  2  2  2  2  2  2     2  3     2  3                  |     42  2.4|
      Fatty Change, Focal                  |             1     1        1                                             |      4  1.0|
      Fatty Change, Multifocal             |                                              1                           |      3  1.0|
      Hematocyst                           |          X                                                               |      1     |
      Hematopoietic Cell Proliferation     |                         1        1              1                        |      9  1.0|
      Hepatodiaphragmatic Nodule           |             X     X        X  X                          X               |      9     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |             1                                                            |      1  1.0|
      Mixed Cell Focus                     |    4        2                 3     2              2  3  2               |     15  2.3|
      Necrosis, Coagulative, Multifocal    |                         1                       2                        |      4  1.5|
      Regeneration                         |                                                                          |      1  3.0|
      Bile Duct, Cyst                      |    X                                                                     |      1     |
      Centrilobular, Fatty Change          | 2                                                                        |      1  2.0|
      Centrilobular, Necrosis, Coagulative | 3                                                                        |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                +                     |  11        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                   +                                                      |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Acinus, Atrophy                      |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                               3                                          |      2  3.0|
      Ulcer                                |                      4                                                   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Edema                                |                      2                                                   |      1  2.0|
      Erosion                              |                                                                          |      4  2.3|
      Mineralization                       |       3        3                                                         |      4  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +        +                              |   4        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Cardiomyopathy                       |    1                                                                     |      2  1.0|
      Mineralization                       |                3                                                         |      2  2.5|
      Atrium, Thrombosis                   | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          | 3  2                                                                     |      8  2.4|
      Hematopoietic Cell Proliferation     |                         1  2                                             |      2  1.5|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      6  2.0|
      Bilateral, Necrosis, Focal           |                                                                          |      1  3.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Focal                   |                               2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  47        |
      Hyperplasia                          |       3        2                                                         |      5  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Cyst                                 |                                  X  X        X  X                        |      7     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia, Focal           |                2                                                         |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                      2        2                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Focal, Glandular        |             2                                                            |      2  2.0|
      Inflammation, Suppurative            |                      1                                                   |      1  1.0|
      Duct, Ectasia                        |                   3           3     2                                    |      8  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                      X                             X                     |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hydrometra                           |                                              3                           |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Atrophy                              | 3                                         2                              |      4  2.8|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Iliac, Sinus, Ectasia                |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      8  2.5|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
      Congestion                           |                                           3                              |      1  3.0|
      Hemorrhage                           | 3                 1                                2                     |      5  2.0|
      Hyperplasia, Lymphoid                |                                        3                                 |      1  3.0|
      Hyperplasia, Plasma Cell             |                   4                 3     2  3     2  3  4               |     15  3.1|
      Sinus, Ectasia                       |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |    2                                                                     |      4  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Depletion Lymphoid                   |                3                          3                              |      5  3.2|
      Hematopoietic Cell Proliferation     |                         4  4     3     3        3  4     2               |     16  3.6|
      Pigmentation, Hemosiderin            |             2                                                            |      4  2.3|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  42        |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hemorrhage                           |                                           2                              |      1  2.0|
      Epithelial Cell, Hyperplasia         |       2     2  2  2     2        2           2     2  2                  |     17  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  49        |
      Acanthosis, Focal                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +        +  +                                                      |  10        |
      Cartilage, Sternum, Degeneration     |                                                                          |      1  3.0|
      Cranium, Fibrous Osteodystrophy      |    3  3        3                                                         |      8  2.9|
      Sternum, Fibrous Osteodystrophy      |                                                                          |      2  2.0|
      Sternum, Osteopetrosis               |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hemorrhage                           |                               1                                          |      2  2.0|
      Brain Stem, Compression              |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Congestion                           |                                           3                              |      2  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1  1     1  1     1        1     1  1  1                 1               |     27  1.0|
      Mineralization                       |                3                                                         |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 3| 3| 6| 4| 3| 3| 3| 6| 5| 4| 4| 3|              |            |
                             DAY ON TEST   | 7| 5| 0| 5| 3| 8| 1| 0| 5| 5| 0| 7| 8| 8| 4| 1| 8| 1| 0| 9|              |            |
                                           | 8| 1| 1| 4| 3| 6| 1| 0| 5| 1| 3| 3| 4| 4| 9| 4| 2| 1| 3| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.06                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |    3                 2           1              1                        |     12  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 3                                   2        3        3                  |      8  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                               2                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   3        |
      Necrosis                             |                   4                                                      |      1  4.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +              +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Abscess                              |                                              3                           |      1  3.0|
      Ectasia                              |                                                          3               |      2  3.0|
      Hyperplasia, Focal, Squamous         |                                                 2                        |      3  2.3|
      Hyperplasia, Multifocal, Squamous    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hydronephrosis                       |                                           2                              |      2  1.5|
      Karyomegaly                          |             1     1  1     1                       1  1  1               |     11  1.0|
      Nephropathy                          | 3  4  4  3  3  4  3  4  2  3  3  3  2  2  2  3  3  2  2  1               |     48  2.8|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                             +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                             +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                             +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                                                             +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Basophilic Focus                     |                                                                2     1   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                2     2   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Regeneration                         |                                                                3         |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                                                             2  2     2   |             
      Centrilobular, Hemorrhage            |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                                   3      |             
      Periportal, Fatty Change             |                                                                          |             
      Serosa, Fibrosis, Focal              |                                                                   3      |             
      Serosa, Pigmentation, Focal          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +  +      |             
      Hemorrhage                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                4  4      |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                             +  +  +  +  +|             
      Acinus, Atrophy                      |                                                             2            |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                             +  +  +  +  +|             
      Hyperplasia                          |                                                                   3      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                             +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                             +  +  +  +  +|             
      Cardiomyopathy                       |                                                             2            |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                             +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                             +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                2         |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                             +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                             +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                X         |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                             +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thrombosis, Chronic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                             +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                             +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                                             +  +  +  +  +|             
      Giant Cell                           |                                                                          |             
      Hypospermia                          |                                                                   4      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Bilateral, Hypospermia               |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                             +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                             +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                             3            |             
      Sinus, Ectasia                       |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                             +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 7| 6|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                             M  +  +  +  +|             
      Hemorrhage                           |                                                                         2|             
      Epithelial Cell, Hyperplasia         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                             +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                             +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                             +  +  +  +  +|             
      Hemorrhage                           |                                                                         3|             
      Brain Stem, Compression              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                             +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                             1  1  1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                             +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                             1            |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                             +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                             +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |                                                             2  3  3  3   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                             +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Parasite Metazoan                    |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  2  2                                    |             
      Ulcer                                |                                                                         4|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                 2                        |             
      Basophilic Focus                     |                1  1                 1           2           1  2        1|             
      Clear Cell Focus                     |                                     1                                    |             
      Degeneration, Cystic                 |                                     1                    1               |             
      Eosinophilic Focus                   |                2                                                  1      |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                   1                                                      |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hepatodiaphragmatic Nodule           |    X                                X                       X            |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                 1                        |             
      Mixed Cell Focus                     |       2                             1        1  1                 1      |             
      Regeneration                         |       3                                                                  |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2     2  2        2  2  2  2  2  3     2  2  2  3     2  2      |             
      Centrilobular, Hemorrhage            |                                                          3               |             
      Centrilobular, Necrosis, Coagulative |                         3                                                |             
      Periportal, Fatty Change             |                                                                         1|             
      Serosa, Fibrosis, Focal              |                            3                                             |             
      Serosa, Pigmentation, Focal          |                            3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +  +              +                              |             
      Hemorrhage                           |                      3                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis, Focal                 |                      3     4              4                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2  2  2  1     2              2  2     1                    1      |             
      Acinus, Hyperplasia, Focal           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  2     2  2        2     2              2  2  2     2     2      |             
      Atrium, Dilatation                   |                                                             3            |             
      Atrium, Thrombosis                   |                         2                                      3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Vacuolization Cytoplasmic, Diffuse   |                      3                                                   |             
      Vacuolization Cytoplasmic, Focal     |                            2                                             |             
      Vacuolization Cytoplasmic, Multifocal| 2                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2           2        2                    2     2           3   |             
      Hyperplasia, Multifocal              |                                           2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Cyst                                 |                            X                    X                 X      |             
      Pigmentation, Hemosiderin            |                                        3                                 |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thrombosis, Chronic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                               3                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                   2                                                      |             
      Duct, Ectasia                        |                                     3           3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                            3                           |             
      Hyperplasia, Focal                   |                                              2     2                     |             
      Hyperplasia, Multifocal              |    2                                   2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2  3  2     3  3     3     3  3  3     2  3  3  3     3     3  3      |             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Giant Cell                           |                                                                         3|             
      Hypospermia                          |                         4                                               3|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Bilateral, Hypospermia               |                                                                          |             
      Interstitial Cell, Hyperplasia       |                      2     2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                                  3         |             
      Hemorrhage                           |                                                       2     4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              | 2                 2        3                    2                        |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                         3                                                |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Hyperplasia, Plasma Cell             |    2  2                          2     2                       2         |             
      Sinus, Ectasia                       | 2  2                                   2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Necrosis                             |                                           3                              |             
      Pigmentation, Hemosiderin            |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 8| 2| 7| 3| 3| 3| 3| 1| 3| 3| 0| 8| 4| 2| 3| 3| 8| 5|             
                                           | 2| 2| 2| 6| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 5| 2| 2| 6| 0| 1| 9| 2| 2| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         | 2  2     2     2  2  2           2     2  2     2  2           2  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Nodular                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                           3   |             
      Brain Stem, Compression              |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            3                                             |             
      Hemorrhage                           |                                                          1               |             
      Infiltration Cellular, Histiocyte    |                   1     1                             1                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                                    2                     |             
      Interstitium, Inflammation           |       2        2           2                          1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |          2     2  2        1  2                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 2  2  2  2  2  3  3  3  1  2  3  2  2  2  2  2  3  2  2  1  4  2  2  2  1|             
      Pigmentation                         |                         3                    2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      3   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Diverticulum                         |                                     4                                    |      1  4.0|
      Parasite Metazoan                    | 2              2                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    | X                                                                        |      3  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |                                                                          |      3  2.0|
      Basophilic Focus                     | 1  1           1  2  2              2           2                        |     16  1.4|
      Clear Cell Focus                     |                                                 2                        |      2  1.5|
      Degeneration, Cystic                 | 1              1     3     1                                             |      6  1.3|
      Eosinophilic Focus                   | 2                 1                                                      |      6  1.7|
      Fatty Change, Diffuse                |                                           3                              |      1  3.0|
      Fatty Change, Focal                  |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Hepatodiaphragmatic Nodule, Multiple |                X                                                         |      1     |
      Infarct                              |                                              4                           |      1  4.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                1                    3                                    |      7  1.4|
      Regeneration                         |                                                                          |      2  3.0|
      Bile Duct, Cyst                      |                   X                                                      |      1     |
      Bile Duct, Hyperplasia               | 2  2  2  1     2  2  2     2  2  2  2           2                        |     33  2.0|
      Centrilobular, Hemorrhage            |                                                                          |      1  3.0|
      Centrilobular, Necrosis, Coagulative |                            2                                             |      3  2.7|
      Periportal, Fatty Change             |                                                                          |      1  1.0|
      Serosa, Fibrosis, Focal              |                                                                          |      2  3.0|
      Serosa, Pigmentation, Focal          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                 +     +     +                 +               |  11        |
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |                                                          3               |      1  3.0|
      Fat, Necrosis, Focal                 |          4                       4     4                                 |      8  3.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Acinus, Atrophy                      |    2  1              2                                                   |     13  1.7|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Ulcer                                |                         4                 4        2                     |      4  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         2                                                |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                       +                  |   1        |
      Dysplasia                            |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Cardiomyopathy                       |    2     2     2  2        2        2     2  2  2     2  1               |     24  1.9|
      Atrium, Dilatation                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |             3                          2     2                           |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                            1                                             |      2  1.5|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Focal                   | 2                       3              2  2                              |     11  2.2|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Angiectasis                          |       2                                                                  |      2  2.0|
      Cyst                                 |                                     X                                    |      5     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
      Thrombosis, Chronic                  | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  44        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Duct, Ectasia                        |                            3                                             |      3  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Atrophy                              |                                                                          |      2  3.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hyperplasia, Multifocal              |                                  2                                       |      3  2.0|
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  49        |
      Atrophy                              | 3     3     3     3  2        2  3  3  3  3     3  2                     |     30  2.8|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Giant Cell                           |                                                                          |      1  3.0|
      Hypospermia                          |                                           4           2                  |      5  3.4|
      Artery, Inflammation, Chronic Active |                                                          3               |      1  3.0|
      Bilateral, Hypospermia               |             4                          4                                 |      2  4.0|
      Interstitial Cell, Hyperplasia       |    2                       2              2           2                  |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Atrophy                              |                                        3              3                  |      4  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Mediastinal, Hemorrhage              | 2                          4                             3               |      7  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
      Pancreatic, Hemorrhage               |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hemorrhage                           |       2  2                 2                                             |      4  2.0|
      Hyperplasia, Plasma Cell             |    2           2                                                         |      8  2.1|
      Sinus, Ectasia                       |                               3                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hemorrhage                           |                                                       2                  |      1  2.0|
      Sinus, Ectasia                       |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       3                                   4                              |      3  3.7|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +               |  41        |
      Hemorrhage                           |          2                                               2               |      3  2.0|
      Epithelial Cell, Hyperplasia         |       2        2     2           2        2        2                     |     20  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  46        |
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hemorrhage                           |       3                 3                                                |      5  3.0|
      Brain Stem, Compression              |                                           3                              |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Congestion                           |          4                 4                                             |      3  3.7|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                               1     1  1                                 |      9  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 1|              |            |
                             DAY ON TEST   | 3| 3| 9| 5| 0| 3| 3| 1| 5| 5| 3| 3| 3| 0| 9| 3| 3| 0| 5| 3|              |            |
                                           | 2| 2| 6| 1| 7| 2| 2| 5| 0| 4| 2| 3| 3| 7| 0| 2| 3| 1| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                               1                 2                        |      2  1.5|
      Bronchiole, Inflammation, Acute      |                                                                          |      1  2.0|
      Interstitium, Inflammation           |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Fungus                               |    3                                                                     |      2  2.5|
      Hemorrhage                           |                         2                                                |      1  2.0|
      Inflammation, Suppurative            | 1  3                                               2                     |     10  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hydronephrosis                       |                            2                                             |      1  2.0|
      Nephropathy                          | 3  3  2  2  2  3  2  2  2  2  3  2  2     3  3  3  2  1                  |     47  2.3|
      Pigmentation                         |             3                                                            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                    2                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Parasite Metazoan                    |                                              2           2               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2        2                        |             
      Basophilic Focus                     |                               1  1     1     1  2        1  2  1         |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Cystic                 |                                  2                 2           1         |             
      Eosinophilic Focus                   |                                  2  2  1        2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  X                                       |             
      Infarct                              |                                           4                              |             
      Mixed Cell Focus                     |                                  2                       1  2  1  3      |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |                               3  2  2  1  2  2  2  2     2  2  2  2      |             
      Centrilobular, Fatty Change          |                                                                         3|             
      Centrilobular, Necrosis, Coagulative |                                                                         3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +              +     +     +|             
      Fat, Necrosis, Focal                 |                                                             4     4      |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                         2|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                     2                 2  2  2  2     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic, Focal     |                                           1                              |             
      Vacuolization Cytoplasmic, Multifocal|                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                 2                        |             
      Cyst                                 |                                                          X  X     X      |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                               X                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3              2     2      |             
      Hyperplasia, Focal                   |                               2                       2           2  2   |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Chronic Active         |                                                             3            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3     3  3  3  3  2  2  3     3  3  3     3|             
      Inflammation, Suppurative            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Testes                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                           4                          3  4|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Myelofibrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                 2                 2      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                  2           3  2           2            |             
      Sinus, Ectasia                       |                                  2           2  2                       2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               M  M  +  M  +  M  M  M  +  +  M  +  +  +  +|             
      Hemorrhage                           |                                                                         3|             
      Epithelial Cell, Hyperplasia         |                                                                2  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia, Basal Cell,  |                                                                          |             
           Focal                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Brain Stem, Compression              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Multifocal                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               1     1     1     1        1  1     1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 3| 3| 3| 5| 4| 3| 3| 3| 3| 9| 4|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 1| 1| 2| 2| 8| 9| 0| 2| 2| 2| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.007                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  2        1                              |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                           2  3  3     3     3        2   |             
      Inflammation, Suppurative            |                                           2  3  3     4     3        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Nephropathy                          |                               3  3  3  2  2  3  3  3     2  2  4  2  2  2|             
      Pigmentation                         |                                              3                           |             
      Interstitial Tissue, Fibrosis, Focal |                                                                         3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Parasite Metazoan                    |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                    3                     |      1  3.0|
      Parasite Metazoan                    |                                              2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Ulcer                                |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     | 1     3                 2     2  1           1           2               |     15  1.5|
      Cytoplasmic Alteration, Focal        |                                                    2                     |      1  2.0|
      Degeneration, Cystic                 | 2  2  3              2  1     2  2     1     2     2                     |     13  1.8|
      Eosinophilic Focus                   |       3                                                                  |      5  2.0|
      Hematopoietic Cell Proliferation     |                                                       1  1               |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Mixed Cell Focus                     |       4        2                 1              3                        |      9  2.1|
      Regeneration                         |    2                                                                     |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  3  2     2     2  2        2           2  2  2                     |     23  2.0|
      Centrilobular, Fatty Change          |                                           4        2                     |      3  3.0|
      Centrilobular, Necrosis, Coagulative |                                                    2     2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                    +                              |   6        |
      Fat, Necrosis, Focal                 |                      4                                                   |      3  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Acinus, Atrophy                      |          2        2  2  1  2                 2                           |      7  1.9|
      Acinus, Hyperplasia, Focal           |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Cardiomyopathy                       | 2        2  2           2           2  2  2  1  2     2  2               |     17  1.9|
      Atrium, Dilatation                   |             3                                            3               |      2  3.0|
      Atrium, Thrombosis                   |          2                                3        4                     |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Multifocal|                               1                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hyperplasia, Focal                   |                      2        2              3     2     2               |      5  2.2|
      Hyperplasia, Multifocal              |          3                                                               |      1  3.0|
      Bilateral, Hyperplasia, Focal        |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Angiectasis                          |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      3     |
      Pars Distalis, Hyperplasia, Focal    |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia, Focal           |                                  2                                       |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Hyperplasia, Focal, Squamous         |                                                 2                        |      1  2.0|
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Atrophy                              |                                              3                           |      4  2.5|
      Hyperplasia, Focal                   | 2                                            2                           |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Multifocal              |                                                       2                  |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                         2     4           2                              |      3  2.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
      Atrophy                              | 3     3        3  3  2        2  2           3  3  3  3  3               |     24  2.8|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hypospermia                          | 4        2                                2     4        4               |      8  3.4|
      Interstitial Cell, Hyperplasia       |          2              2  2                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Atrophy                              |          3                                                               |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Mediastinal, Hemorrhage              |             3  2           3              2     2        2               |      8  2.3|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Hyperplasia, Plasma Cell             |                2        3     2              2                           |      8  2.3|
      Sinus, Ectasia                       |       2                          2           2                           |      7  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Sinus, Ectasia                       |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Edema                                |       4                                                                  |      1  4.0|
      Fibrosis                             |          3                 3                    3                        |      3  3.0|
      Hematopoietic Cell Proliferation     |                                           3           2  4               |      4  3.0|
      Necrosis                             |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  M               |  22        |
      Hemorrhage                           |                                           2                              |      2  2.5|
      Epithelial Cell, Hyperplasia         | 2  2           2  2     2                       2                        |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +               |  31        |
      Galactocele                          |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Cyst Epithelial Inclusion            |                         X                                                |      1     |
      Ulcer                                |                                                          4               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 3| 7| 7| 6| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 3| 3| 9| 2| 5| 3| 0| 9| 6| 4| 3| 3| 0| 3| 6| 3| 3| 2| 5| 5|              |            |
                                           | 2| 2| 4| 4| 2| 2| 1| 4| 6| 5| 2| 2| 5| 0| 5| 2| 2| 4| 2| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    0.007                                  | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epidermis, Hyperplasia, Basal Cell,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Hemorrhage                           |                   3                                                      |      2  3.0|
      Brain Stem, Compression              |                         2     2                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Granuloma, Multifocal                |                                                    1                     |      1  1.0|
      Infiltration Cellular, Histiocyte    |                         1              1        1     1                  |     11  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                  2     1                                 |      4  1.5|
      Interstitium, Inflammation           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Fungus                               |                                        4                                 |      7  2.9|
      Inflammation, Suppurative            |    1        4                          3  1        1                     |     11  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Necrosis                             |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  35        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 3  3  3  2  1  2  2  2  3  2  4  3  1  2  1  3  3  3  2  2               |     34  2.4|
      Pigmentation                         |                      2                                                   |      2  2.5|
      Interstitial Tissue, Fibrosis, Focal |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  34        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Parasite Metazoan                    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  2           3                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Basophilic Focus                     |                                  2     4        2  2        2  3        2|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                  2  1  2           2        2  2     2   |             
      Eosinophilic Focus                   |                                                    2     3               |             
      Fatty Change, Focal                  |                                                                          |             
      Fatty Change, Multifocal             |                                                                          |             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  1                          1           1|             
      Hepatodiaphragmatic Nodule           |                                           X                              |             
      Infarct                              |                                                          4               |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                               2  2  2        2  2           3     2      |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration                         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                               2  2  2  2     2  2  2        2  2     2   |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                                3         |             
      Portal Vein, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                               1        2                 2           2   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          3               |             
      Inflammation, Focal, Suppurative     |                                                                         1|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                           2  2  2     2     2  2     2  2|             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Focal                   |                               3  2     3           1     2     3         |             
      Hyperplasia, Multifocal              |                                              3                       2   |             
      Necrosis, Diffuse                    |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
      Bilateral, Hyperplasia, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Cyst                                 |                                     X           X                        |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                    X                     |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Chronic Active         |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Hyperplasia, Focal                   |                                  2                 2           1         |             
      Hyperplasia, Multifocal              |                                                                   2      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3  3  3  3     2  3  3  2     3  3     3   |             
                                            __________________________________________________________________________|             
   Testes                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Giant Cell                           |                                                                         1|             
      Granuloma Sperm                      |                                                                          |             
      Hypospermia                          |                                     4                 3  4  4            |             
      Mineralization                       |                                                             2            |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                  2        3                              |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                           3                              |             
      Sinus, Ectasia                       |                               2     2     2     2           2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         4|             
      Necrosis                             |                                     4                                    |             
      Red Pulp, Atrophy                    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  M  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Congestion                           |                                                       3                  |             
      Epithelial Cell, Hyperplasia         |                                     2  2        2  2           2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                                          |             
      Sebaceous Gland, Hyperplasia, Focal  |                               4                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                          |             
      Brain Stem, Compression              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           4                              |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               1                       1                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    1                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                        2                                 |             
      Capillary, Thrombosis                |                                                                          |             
      Interstitium, Inflammation           |                                                             1            |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                      3   |             
      Hemorrhage                           |                                           1                              |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                      3   |             
      Inflammation, Suppurative            |                               1                                      3   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Cataract                             |                                     2                                    |             
      Retina, Degeneration                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 1| 4| 2| 3| 3| 3| 1| 8| 3| 3| 5| 9| 0|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 2| 5| 1| 5| 2| 2| 2| 4| 1| 2| 2| 7| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Infarct                              |                                                                          |             
      Nephropathy                          |                               3  3  3  2  1  3  3  2  2  2  3  3  2  3  2|             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Parasite Metazoan                    | 2  3                             3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               2                             1            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     | 2  4  2        2              2     2     2  1              2     2      |             
      Clear Cell Focus                     |          2                                                               |             
      Degeneration, Cystic                 | 2  2           2  2           1     2           1        3  2  1  3      |             
      Eosinophilic Focus                   | 2  2  2  2                    2              3  2        3  2  2  2      |             
      Fatty Change, Focal                  |       2                                                                  |             
      Fatty Change, Multifocal             |                      2                                                   |             
      Hematocyst                           |                                                             X            |             
      Hematopoietic Cell Proliferation     |                                                       1                  |             
      Hepatodiaphragmatic Nodule           |                                              X                       X   |             
      Infarct                              |             4                                                            |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                1         |             
      Mixed Cell Focus                     |          2     2  2     2     2           1  2  2  3                     |             
      Necrosis, Coagulative, Focal         |                                  2                                       |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration                         |                      2                                                   |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |          2     2  2           2  2           2  2  2        2  2  2      |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Portal Vein, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1                 2                          1  2  4  2  1     2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                         3                                                |             
      Ulcer                                |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  2        1     2     2     2     2  2  2  2     2  2     2  2  1|             
      Atrium, Dilatation                   |                                                       4                  |             
      Atrium, Thrombosis                   | 2     2              2                                         4  2  4   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                         2        2                       1     2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       3                             2  2     2              2           3|             
      Hyperplasia, Multifocal              |                                                       2  3     3         |             
      Necrosis, Diffuse                    |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                   2      |             
      Bilateral, Hyperplasia, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                             X            |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                 2                    2   |             
      Duct, Ectasia                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                3                                3                        |             
      Hyperplasia, Focal                   |                               2                 2                        |             
      Hyperplasia, Multifocal              |          2     3                                                         |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
      Inflammation, Chronic Active         |                               2  2                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3     3  3  3  2  2        3  3  3  3     3  3  3     3  3  2  3      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Giant Cell                           |                                                                          |             
      Granuloma Sperm                      |                         2                                                |             
      Hypospermia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                   2                                                      |             
      Mediastinal, Sinus, Ectasia          |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2                                                                        |             
      Hyperplasia, Plasma Cell             |       3                                                                  |             
      Sinus, Ectasia                       |       3        2                                2  2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                               X                                          |             
      Fibrosis                             |                                                          2  2            |             
      Hematopoietic Cell Proliferation     |       3                                               4                  |             
      Necrosis                             |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  M  M  +  +  M  +  M  M  +  M  +  M  +  M|             
      Congestion                           |                                                                          |             
      Epithelial Cell, Hyperplasia         | 2           2        2                 2  2              2     2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                                          |             
      Sebaceous Gland, Hyperplasia, Focal  |                                                                2         |             
      Subcutaneous Tissue, Edema           | 4                                                                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3  3           4                                2|             
      Brain Stem, Compression              |    3                             3                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1           1           1                    1  1     1     1  1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           1                 1            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                  1              1                        |             
      Capillary, Thrombosis                |                                                                          |             
      Interstitium, Inflammation           |                   1                                               2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |             3     3                 2                    3               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                   3                                                      |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Suppurative            |             2     2  2        1     3              1     3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 9| 7| 6| 4| 4| 3| 3| 8| 3| 1| 3| 9| 6| 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 5| 5|             
                                           | 3| 7| 9| 1| 1| 2| 2| 7| 8| 4| 2| 4| 3| 3| 0| 2| 2| 2| 5| 4| 2| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.015                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 3  3  1  1  2  2  3  2  2  2  3  3  2  2  2  3  3  3  2  3  3  3  3  3  2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Erosion                              |                                                                   2      |      1  2.0|
      Parasite Metazoan                    |                                  1        2                              |      6  2.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Parasite Metazoan                    |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     | 1                 3           2  3           3        1                  |     23  2.2|
      Clear Cell Focus                     |                                              3                           |      2  2.5|
      Degeneration, Cystic                 | 2  2           2  2           1  2     2  2  3  2  2     1  2  2  2      |     33  1.9|
      Eosinophilic Focus                   |                   4              3        2     4           2  2         |     19  2.4|
      Fatty Change, Focal                  |                                                                      1   |      2  1.5|
      Fatty Change, Multifocal             |                      2                                                   |      2  2.0|
      Hematocyst                           |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                   1                                         1            |      6  1.0|
      Hepatodiaphragmatic Nodule           |                                  X        X  X           X           X   |      8     |
      Infarct                              |    4                                                              3      |      4  3.8|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Mixed Cell Focus                     | 3           2  1              2     3     2  2                 2         |     24  2.1|
      Necrosis, Coagulative, Focal         |                                                                          |      1  2.0|
      Necrosis, Coagulative, Multifocal    |                                                    2                     |      1  2.0|
      Regeneration                         |                         3           3                                    |      3  2.7|
      Bile Duct, Cyst                      |                                                       X                  |      1     |
      Bile Duct, Hyperplasia               | 2     2        2              2  2     2              2  2     2  2      |     31  2.0|
      Centrilobular, Fatty Change          |                                  1     2                                 |      2  1.5|
      Centrilobular, Necrosis, Coagulative |    4  2  3                 4           2                    2     3      |      8  2.9|
      Portal Vein, Thrombosis              |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
      Fat, Necrosis, Focal                 |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Acinus, Atrophy                      |                                     1  1  2     2     2     2            |     18  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Erosion                              |                                                       1                  |      1  1.0|
      Inflammation, Acute                  |                                                       2              2   |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |    3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Erosion                              |                                                    3              4      |      3  3.3|
      Inflammation, Focal, Suppurative     |                                                                          |      1  1.0|
      Ulcer                                |    3     3                                                               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Cardiomyopathy                       | 2  1           2           2  2  2  2        2           1  2  2     1  2|     36  1.9|
      Atrium, Dilatation                   |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |    4  4  4        3  3     2     X     4     3              4     3      |     18  3.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  63        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Angiectasis                          |                2                                                  2      |      2  2.0|
      Atrophy                              |                   4                                                      |      1  4.0|
      Necrosis, Diffuse                    |                                                                   4      |      1  4.0|
      Vacuolization Cytoplasmic, Focal     | 1                    1                                                   |      8  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  63        |
      Hyperplasia, Focal                   |          2     2        2  2     2  2           2     2                  |     20  2.2|
      Hyperplasia, Multifocal              |    2                                                                     |      6  2.5|
      Necrosis, Diffuse                    |                                                                   4      |      1  4.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Bilateral, Hyperplasia, Multifocal   |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Angiectasis                          |                   2                                                      |      3  2.0|
      Cyst                                 |          X                                                               |      3     |
      Hemorrhage                           |                         2                                                |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                2         |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia, Focal           |          2           2                 2                          2      |      4  2.0|
      Follicle, Cyst                       |                                                                X         |      1     |
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   3        |
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  60        |
      Hyperplasia, Focal, Glandular        |                                              2                           |      1  2.0|
      Inflammation, Chronic Active         |                                  2                                3      |      3  2.3|
      Inflammation, Suppurative            |                                              3                           |      3  2.3|
      Duct, Ectasia                        |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Atrophy                              |                                                                          |      3  3.0|
      Hyperplasia, Focal                   |                2  2           1                 2                       2|     10  1.8|
      Hyperplasia, Multifocal              |                                                                          |      3  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                          3               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Atrophy                              | 2  3  3  2  3  3  3  3     3  3  3  3  3  3  3  3  3  3  3  2  3  3      |     51  2.8|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Giant Cell                           |                                                                          |      1  1.0|
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Hypospermia                          |                      2                                      4            |      6  3.5|
      Mineralization                       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                         2                                            2  2|      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Mediastinal, Hemorrhage              |    2                                                     3               |      5  2.4|
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Hemorrhage                           |    2                                                                     |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
      Sinus, Ectasia                       | 2           3     2  3                                                   |     13  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Ectopic Tissue                       |                                                                          |      1     |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.7|
      Necrosis                             |                                                                          |      1  4.0|
      Red Pulp, Atrophy                    |          4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  M  +|  47        |
      Congestion                           |                                                                          |      1  3.0|
      Epithelial Cell, Hyperplasia         |    2  2        2                 2  2                             2     2|     19  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  61        |
      Hyperplasia, Nodular                 |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Hyperkeratosis, Focal                |    2                                                                     |      1  2.0|
      Sebaceous Gland, Hyperplasia, Focal  |                                                             2            |      3  2.7|
      Subcutaneous Tissue, Edema           |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                             2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Hemorrhage                           |                         1                             4                 2|      7  2.7|
      Brain Stem, Compression              |                2                                                         |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                                          2               |      1  2.0|
      Infiltration Cellular, Histiocyte    |                   1     1     1        1     1           1     1  1      |     18  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 5| 4|            |
                             DAY ON TEST   | 3| 3| 9| 6| 4| 3| 3| 9| 9| 5| 3| 3| 1| 7| 4| 3| 3| 9| 9| 6| 3| 3| 7| 6| 9|            |
                                           | 3| 3| 3| 6| 1| 3| 3| 4| 1| 4| 3| 3| 1| 2| 1| 3| 3| 1| 4| 5| 3| 3| 3| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.015                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |       3                                   2                              |      5  1.6|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                               2                                          |      4  1.5|
      Capillary, Thrombosis                |                                                             2            |      1  2.0|
      Interstitium, Inflammation           |                                                             3            |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Fungus                               |             3  2        3                                                |      8  2.8|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Hyperplasia, Multifocal              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |             4  2        2                          2        2     3      |     15  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   2        |
      Cataract                             |                                  3                                       |      2  2.5|
      Retina, Degeneration                 |                                  3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  64        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  65        |
      Cyst                                 |                                                                          |      1     |
      Infarct                              |       3                                                                  |      1  3.0|
      Nephropathy                          | 3  2  3  2  3  3  3  3  2  3  3  3  2  2  2  3  3  2  2  1  3  3  3  2  2|     65  2.5|
      Pigmentation                         |                      4                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  64        |
      Ectasia                              |                                        4                                 |      1  4.0|
      Hemorrhage                           |                                                       3                  |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                           +              +  +  +  +      |             
      Edema                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                           +              +  +  +  +      |             
      Parasite Metazoan                    |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                           +              +  +  +  +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   |                                           +              +  +  +  +      |             
      Basophilic Focus                     |                                                                   2      |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                             3  3  1      |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Multifocal             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             1     1      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                           4                              |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                                                                3  2      |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |                                                             2  2  2      |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis, Coagulative,|                                                                          |             
           Focal                           |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                          3  2  2  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Fat, Necrosis, Focal                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                           +              +  +  +  +      |             
      Metaplasia                           |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                           +              +  +  +  +      |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                           +              +  +  +  +      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                           +              +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Erosion                              |                                                             1  3         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                           +              +  +  +  +      |             
      Cardiomyopathy                       |                                           2              2        2      |             
      Inflammation, Suppurative            |                                                                          |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                             3  4         |             
      Ventricle Right, Thrombosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                           +              +  +  +  +      |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                           +              +  +  +  +      |             
      Vacuolization Cytoplasmic, Focal     |                                                                2         |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                           +              +  +  +  +      |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                           +              +  +  +  +      |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                           +              +  +  +  +      |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                           +              +  +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +              +  +  +  +      |             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Chronic Active         |                                           2                              |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Prostate                                |                                           +              +  +  +  +      |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +              +  +  +  +      |             
      Atrophy                              |                                                             3  3         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                           +              +  +  +  +      |             
      Hypospermia                          |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                           +              +  +  +  +      |             
      Atrophy                              |                                                                          |             
      Myelofibrosis                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +              +  +  +  +      |             
      Mediastinal, Hemorrhage              |                                           3                       2      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Hemorrhage               |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                           +              +  +  +  +      |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                           +              +  +  +  +      |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                           +              +  +  +  +      |             
      Fibrosis                             |                                                                3         |             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                           +              +  +  +  +      |             
      Hemorrhage                           |                                                          2               |             
      Epithelial Cell, Hyperplasia         |                                                             2  2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           +              M  +  +  M      |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                           +              +  +  +  +      |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Hyperkeratosis, Focal                |                                                                          |             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Cell, Focal                      |                                                                          |             
      Sebaceous Gland, Hyperplasia, Focal  |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Sternum, Osteopetrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                           +              +  +  +  +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Brain Stem, Compression              |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                           +              +  +  +  +      |             
      Congestion                           |                                                          4               |             
      Hemorrhage                           |                                                                1         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Focal                  |                                                             2            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           1                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
      Capillary, Thrombosis                |                                                                          |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                           +              +  +  +  +      |             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                           +              +  +  +  +      |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +              +  +  +  +      |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 5| 9| 5| 5| 5| 5| 1| 1| 6| 1| 5| 5|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 2| 1| 3| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                           +              +  +  +  +      |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |                                           1              3  3  3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                           +              +  +  +  +      |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                    1         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          1           3  2  2  2     3  1  3  3  4  2           2     2  2|             
      Clear Cell Focus                     |                                                                      2   |             
      Cyst                                 | X                                                                        |             
      Degeneration, Cystic                 | 3     2        3  1  1  3  2  2     3        2     2  2        3  2  1   |             
      Eosinophilic Focus                   | 2        2     3  3  2  2        3  4        2  2           2  2        2|             
      Fatty Change, Multifocal             |          1                       1                          1           1|             
      Hematopoietic Cell Proliferation     | 2        1                 2  1  1           1  1              1         |             
      Hepatodiaphragmatic Nodule           |                                                    X                 X   |             
      Infarct                              |                                           4        3  4     4            |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |             1                                                            |             
      Mixed Cell Focus                     | 3                    2  2                    2     2              1  2   |             
      Necrosis, Coagulative, Multifocal    |                   2                                                      |             
      Regeneration                         |                                     3                                    |             
      Bile Duct, Hyperplasia               |                               3                             2  2     2  1|             
      Centrilobular, Fatty Change          |                                                 2                        |             
      Centrilobular, Necrosis, Coagulative,|                                                                          |             
           Focal                           |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                               3  2     2     2        2     2        3  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +  +  +|             
      Fat, Necrosis, Focal                 |                                                                      4  4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                      2                                                   |             
      Acinus, Atrophy                      |    2                          2     2  2     1  2                 2      |             
      Acinus, Hyperplasia, Focal           |                   2                                         2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Degeneration, Cystic                 |                                                                   1      |             
      Erosion                              |                                                       3  1  2            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                    +                             +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2        2     2        2           2  2     2  2  2     2  2  2   |             
      Inflammation, Suppurative            |                                                                          |             
      Atrium, Dilatation                   |                                                          3               |             
      Atrium, Thrombosis                   | 2  2              3     3     3  2              4           2            |             
      Ventricle Right, Thrombosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Hyperplasia, Focal        |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic, Focal     |                            2                                             |             
      Vacuolization Cytoplasmic, Multifocal|                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2  2                 1     2  2        1        2                        |             
      Hyperplasia, Multifocal              |                                                                         3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Cyst                                 |                                                                         X|             
      Ectopic Tissue                       |                                                                         X|             
      Pars Distalis, Hyperplasia, Focal    |                                                    2                    2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        | 3                                                                        |             
      Inflammation, Chronic Active         |                                                                         1|             
      Inflammation, Suppurative            |                                              1                           |             
      Duct, Ectasia                        | 3                                                                    3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               2           1                              |             
      Inflammation, Chronic Active         |                   3                                1  3     3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |             1                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        3     3  3        3     3  3                          3         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                2        2|             
      Interstitial Cell, Hyperplasia       |                                                       2  2     2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                       |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |             4                    3              2     3           2  2  2|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                   3      |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |             2                          2                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 3                    2  3  4                                2  3         |             
      Sinus, Ectasia                       |             3           2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                        2                                 |             
      Hyperplasia, Lymphoid                |             3                                                            |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 4        3              4  3     3           3  4           3  3     3  4|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Hemorrhage                           |             3                                                            |             
      Epithelial Cell, Hyperplasia         | 2                                   2           2           2     2     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  M  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                                                       2                  |             
      Hair Follicle, Hyperplasia, Basal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Cell, Focal                      |                                                                          |             
      Sebaceous Gland, Hyperplasia, Focal  |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                       +                  |             
      Sternum, Osteopetrosis               |                                                       3                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Brain Stem, Compression              |             2                                                            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Hemorrhage                           |                2                                                     2   |             
      Infiltration Cellular, Histiocyte    |                   1           1  1                    1     1     1     1|             
      Pigmentation, Focal                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                               2              1     2                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                        3                                1|             
      Capillary, Thrombosis                |                                                                          |             
      Interstitium, Inflammation           | 1                             2                 1           2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                3                                      3        2         |             
      Hyperplasia, Focal                   |                3                                                         |             
      Inflammation, Suppurative            | 2              2     1                 3              3        2     3   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 3| 7| 6| 6| 6| 5| 7| 7| 6| 5| 5| 6| 5| 5| 5| 4| 6| 5| 5| 4| 4|             
                             DAY ON TEST   | 9| 4| 3| 2| 8| 3| 9| 5| 1| 2| 2| 0| 6| 5| 3| 6| 4| 3| 1| 5| 1| 8| 0| 7| 7|             
                                           | 3| 9| 8| 4| 3| 2| 4| 1| 7| 4| 3| 4| 3| 6| 0| 1| 5| 1| 1| 6| 4| 2| 1| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.03                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                              4                           |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 3  3     2  2  3  3  3  2  2  3  2  3  3     3  2  2  1  1  2  3  2  3  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Edema                                |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    |                         2                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Parasite Metazoan                    |                                              2                           |      3  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Basophilic Focus                     |    4        1     4     2     2  2     2  2        3     2               |     25  2.3|
      Clear Cell Focus                     |                         2                                                |      2  2.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 | 2           2  2  3  2  2     2  2     3  2  2     2     2               |     31  2.2|
      Eosinophilic Focus                   |    1  2        3  3  2        2  3     2  2  3     2  3  2               |     26  2.3|
      Fatty Change, Multifocal             |                                              1                           |      5  1.0|
      Hematopoietic Cell Proliferation     |                1                       1     1           1               |     14  1.1|
      Hepatodiaphragmatic Nodule           |                X                                         X               |      4     |
      Infarct                              |                                                                          |      5  3.8|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Mixed Cell Focus                     |             2        2  2  1                       2                     |     14  2.0|
      Necrosis, Coagulative, Multifocal    |       2                          2                                       |      3  2.0|
      Regeneration                         |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                   2                       1                              |     10  1.9|
      Centrilobular, Fatty Change          |                                     1                                    |      2  1.5|
      Centrilobular, Necrosis, Coagulative,|                                                                          |            |
           Focal                           |                2                                                         |      1  2.0|
      Centrilobular, Necrosis, Coagulative |                      2        2     3        1  4  2                     |     18  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                          +                        |   6        |
      Fat, Necrosis, Focal                 |                      4                          3                        |      5  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Metaplasia                           |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      7  1.9|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ulcer                                |                                              3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Erosion                              |       2                                                                  |      6  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Cardiomyopathy                       | 2           1     2     2              2  2           2  2               |     24  2.0|
      Inflammation, Suppurative            |                                                    2                     |      1  2.0|
      Atrium, Dilatation                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   | 2              3  3  3        4  3  4        4                           |     18  3.0|
      Ventricle Right, Thrombosis          |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Bilateral, Hyperplasia, Focal        |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Vacuolization Cytoplasmic, Focal     |                               2                                          |      3  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Hyperplasia, Focal                   |    2                                2  1        2                        |     11  1.7|
      Hyperplasia, Multifocal              | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Ectopic Tissue                       |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                   +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  48        |
      Hyperplasia, Focal, Glandular        |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 2                 2                                      2               |      5  1.8|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Duct, Ectasia                        |             2                                                            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |       2     2              4                                             |      8  2.6|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  48        |
      Atrophy                              |                3  3  3        2  3           3  2     3                  |     18  2.8|
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hypospermia                          |          4                                                               |      3  2.7|
      Interstitial Cell, Hyperplasia       |                            2           2                                 |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Mediastinal, Hemorrhage              |                                        2        2                        |     11  2.5|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  49        |
      Fibrosis                             | 3                                                                        |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                         2              3  3                              |      9  2.8|
      Sinus, Ectasia                       |                         2              2     2        3                  |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Fibrosis                             | 3                                                                        |      1  3.0|
      Hemorrhage                           |                                                 3                        |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                3              3                                          |      3  3.0|
      Hematopoietic Cell Proliferation     |                3           4  4  3     3     3  3  4     4               |     21  3.4|
      Hemorrhage                           |                                              2                           |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  +  +               |  40        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Epithelial Cell, Hyperplasia         |                   2           2  2              2  2     2               |     14  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +  +               |  37        |
      Galactocele                          |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Hair Follicle, Hyperplasia, Basal    |                                                                          |            |
          Cell, Focal                      |                   1                                                      |      1  1.0|
      Sebaceous Gland, Hyperplasia, Focal  |                                                          2               |      1  2.0|
      Subcutaneous Tissue, Edema           |                                              3                           |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +                                          |   2        |
      Sternum, Osteopetrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Hemorrhage                           |          2                                                               |      2  2.0|
      Inflammation, Suppurative            |                                                    2                     |      1  2.0|
      Brain Stem, Compression              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Congestion                           |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      3  1.7|
      Infiltration Cellular, Histiocyte    |                   1                    1                                 |      9  1.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                  3                       2               |      6  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05163-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 07:17:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 5| 6| 6| 6| 5| 3| 6| 6| 6| 5| 5| 7| 6| 6| 5| 5|              |            |
                             DAY ON TEST   | 2| 7| 5| 2| 3| 9| 6| 3| 3| 7| 9| 6| 3| 3| 3| 1| 9| 2| 8| 3|              |            |
                                           | 4| 7| 8| 5| 1| 4| 3| 4| 0| 7| 3| 3| 8| 8| 0| 1| 4| 2| 1| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      A     |
    0.03                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |             2                       2                                    |      2  2.0|
      Bronchiole, Inflammation, Acute      |                                                                          |      2  2.0|
      Capillary, Thrombosis                |                3              2                                          |      2  2.5|
      Interstitium, Inflammation           |                2              2              2                           |      7  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Foreign Body                         |                                        2                                 |      1  2.0|
      Fungus                               |                         3           2                                    |      5  2.6|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 2        2           2  2           2  3           2                     |     14  2.2|
      Ulcer                                |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Inflammation, Suppurative            |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   1        |
      Cataract                             |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ectasia                              |                         4  3                                             |      2  3.5|
      Hyperplasia, Focal, Squamous         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Cyst                                 |                X                                                         |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                    4                     |      1  4.0|
      Nephropathy                          | 3     3  2  3  3  3  2  2  2  3  3  2  2  2  3  3  3  1  2               |     46  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  50        |
      Ectasia                              |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
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                             ----------              END OF REPORT             ----------                                           
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