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https://ntp.niehs.nih.gov/go/1573

TDMS Study 05165-02 Pathology Tables

NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95
Route: DOSED FEED                                                                                                 Time: 20:28:46




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-69-5

       Lock Date:  01/10/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                  9            9           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            9           11           11                                     
    Moribund Sacrifice                                 4            3            3            4                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                39           38           36           35                                     
  Missing                                                           1                                                               

  Animals Examined Microscopically                    60           59           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (59)         (59)         (60)         (60)                                   
      Necrosis, Focal                                  1 (2%)                                                                       
   Liver                                              (60)         (59)         (60)         (60)                                   
      Angiectasis                                      2 (3%)                    1 (2%)                                             
      Basophilic Focus                                 2 (3%)       4 (7%)       3 (5%)                                             
      Clear Cell Focus                                              2 (3%)       3 (5%)                                             
      Eosinophilic Focus                              10 (17%)      8 (14%)     10 (17%)      7 (12%)                               
      Hematopoietic Cell Proliferation                 2 (3%)       4 (7%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
      Bile Duct, Cyst                                                            2 (3%)                                             
      Bile Duct, Dilatation                                         1 (2%)                                                          
      Hepatocyte, Fatty Change                         7 (12%)      6 (10%)      5 (8%)       6 (10%)                               
      Hepatocyte, Hypertrophy                          2 (3%)                                                                       
      Periportal, Inflammation, Chronic Active                      1 (2%)                                                          
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Mesentery                                          (5)          (6)          (4)          (1)                                    
      Fat, Inflammation, Chronic Active                4 (80%)      3 (50%)      1 (25%)      1 (100%)                              
   Pancreas                                           (59)         (59)         (59)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Acinus, Atrophy                                               1 (2%)       3 (5%)       2 (3%)                                
      Duct, Cyst                                                                 1 (2%)                                             
   Pharynx                                                                      (1)                                                 
      Submucosa, Palate, Infiltration Cellular,                                                                                     
           Mast Cell                                                             1 (100%)                                           
   Stomach, Forestomach                               (59)         (59)         (60)         (60)                                   
      Acanthosis, Multifocal                                                     1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (59)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Mucosa, Hyperplasia                                                                     1 (2%)                                
      Submucosa, Inflammation, Chronic Active          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
      Degeneration, Chronic                            2 (3%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (60)                                   
      Cyst                                             2 (3%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                                   2 (3%)       1 (2%)       1 (2%)                                
      Hypertrophy                                      3 (5%)       6 (10%)      5 (8%)       3 (5%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)       2 (3%)                    1 (2%)                                
   Adrenal Medulla                                    (58)         (59)         (60)         (60)                                   
      Hyperplasia                                                   2 (3%)       1 (2%)       3 (5%)                                
   Parathyroid Gland                                  (52)         (54)         (57)         (57)                                   
      Cyst                                                                                    1 (2%)                                
   Pituitary Gland                                    (57)         (58)         (59)         (58)                                   
      Pars Distalis, Angiectasis                                    2 (3%)                                                          
      Pars Distalis, Cyst                              4 (7%)                                 3 (5%)                                
      Pars Distalis, Hyperplasia                       9 (16%)     14 (24%)     13 (22%)     11 (19%)                               
      Pars Distalis, Hypertrophy                                                              1 (2%)                                
      Pars Intermedia, Cyst                                         1 (2%)                                                          
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (59)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ultimobranchial Cyst                                          1 (2%)                                                          
      Follicle, Cyst                                   2 (3%)       1 (2%)                                                          
      Follicle, Cyst, Multiple                                                                1 (2%)                                
      Follicular Cell, Hyperplasia                     4 (7%)       2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (51)         (45)         (48)         (44)                                   
      Duct, Dilatation                                              1 (2%)       1 (2%)                                             
   Ovary                                              (59)         (59)         (59)         (60)                                   
      Angiectasis                                                   1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Mineralization                                                             2 (3%)       1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Bilateral, Inflammation, Granulomatous                        2 (3%)                    1 (2%)                                
      Bilateral, Periovarian Tissue, Cyst                                        1 (2%)                                             
      Bilateral, Follicle, Cyst                                     3 (5%)       2 (3%)       4 (7%)                                
      Follicle, Cyst                                  26 (44%)     22 (37%)     23 (39%)     21 (35%)                               
      Periovarian Tissue, Cyst                         1 (2%)       3 (5%)                    8 (13%)                               
      Periovarian Tissue, Inflammation,                                                                                             
          Granulomatous                                1 (2%)                                                                       
      Rete Ovarii, Hyperplasia                         2 (3%)                                 1 (2%)                                
   Uterus                                             (60)         (59)         (60)         (60)                                   
      Endometrium, Hyperplasia, Cystic, Glandular     57 (95%)     57 (97%)     52 (87%)     57 (95%)                               
      Endometrium, Vein, Thrombosis                                 2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
      Myelofibrosis                                   21 (35%)     18 (31%)     23 (38%)     34 (57%)                               
      Femoral, Myelofibrosis                                        1 (2%)                    1 (2%)                                
   Lymph Node                                         (9)          (7)          (4)          (7)                                    
      Inguinal, Inflammation, Chronic Active                        1 (14%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                            1 (14%)                                                         
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (11%)                                                                      
      Mediastinal, Inflammation, Acute                                                        1 (14%)                               
   Lymph Node, Mandibular                             (59)         (59)         (57)         (60)                                   
      Congestion                                                    2 (3%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Histiocyte                                                       6 (10%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Lymphocyte, Necrosis                             1 (2%)                                                                       
   Lymph Node, Mesenteric                             (52)         (51)         (51)         (52)                                   
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Histiocytic, Macrophage            40 (77%)     33 (65%)     31 (61%)     42 (81%)                               
      Infiltration Cellular, Histiocyte                5 (10%)      3 (6%)       9 (18%)      9 (17%)                               
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Lymphatic, Cyst                                                            1 (2%)                                             
      Lymphocyte, Necrosis                             1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (60)         (59)         (60)         (59)                                   
      Depletion Lymphoid                                                         2 (3%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 8 (13%)     12 (20%)      7 (12%)      4 (7%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Lymphocyte, Necrosis                             1 (2%)                                                                       
   Thymus                                             (55)         (52)         (54)         (58)                                   
      Concretion                                                    1 (2%)                                                          
      Depletion Lymphoid                               6 (11%)      2 (4%)       8 (15%)      4 (7%)                                
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (59)         (58)         (59)                                   
      Hyperplasia, Cystic                                           2 (3%)       2 (3%)       2 (3%)                                
   Skin                                               (60)         (59)         (60)         (60)                                   
      Inguinal, Ulcer                                                            1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                               1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Acute                      1 (2%)                                                          
      Tail, Ulcer                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (59)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
      Compression                                      1 (2%)       3 (5%)       3 (5%)                                             
      Necrosis                                         1 (2%)                                                                       
      Neuron, Degeneration                                                       1 (2%)                                             
   Peripheral Nerve                                   (2)          (1)          (1)          (4)                                    
      Sciatic, Axon, Degeneration                      2 (100%)     1 (100%)     1 (100%)     4 (100%)                              
   Spinal Cord                                        (2)          (1)          (1)          (4)                                    
      Axon, Degeneration                               1 (50%)                                2 (50%)                               
      Lumbar, Axon, Nerve, Degeneration                1 (50%)                   1 (100%)     4 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                              2 (3%)                                                          
      Alveolar Epithelium, Hyperplasia, Macrophage                               1 (2%)                                             
      Mediastinum, Inflammation, Chronic Active        1 (2%)       1 (2%)                                                          
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   4 (7%)       5 (8%)       3 (5%)       7 (12%)                               
      Perivascular, Inflammation, Chronic Active                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                       (1)                                    
      Atrophy                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Amyloid Deposition                               1 (2%)                    1 (2%)                                             
      Metaplasia, Focal, Osseous                                                              1 (2%)                                
      Nephropathy, Chronic                            22 (37%)     27 (46%)     16 (27%)     18 (30%)                               
      Cortex, Cyst                                                               1 (2%)                                             
      Cortex, Infarct                                               1 (2%)       2 (3%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            6            1            4                                     
    Moribund Sacrifice                                 2            2                         1                                     
  Survivors                                                                                                                         
    Natural Death                                      1            1                                                               
    Terminal Sacrifice                                41           41           49           45                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Mucosa, Hyperplasia                                           1 (2%)                                                          
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
      Peyer's Patch, Ulcer, Chronic Active             1 (2%)                                                                       
   Intestine Small, Ileum                             (60)         (60)         (59)         (59)                                   
      Peyer's Patch, Inflammation, Acute                            1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                                           1 (2%)                                             
      Clear Cell Focus                                 6 (10%)      2 (3%)       2 (3%)                                             
      Clear Cell Focus, Multiple                                    3 (5%)                                                          
      Congestion                                                                              1 (2%)                                
      Eosinophilic Focus                               2 (3%)       3 (5%)       3 (5%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Necrosis                                         2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic                        6 (10%)      2 (3%)       3 (5%)       1 (2%)                                
      Bile Duct, Cyst                                                            1 (2%)                                             
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Hepatocyte, Fatty Change                        19 (32%)     17 (28%)      5 (8%)       6 (10%)                               
      Serosa, Fibrosis                                              1 (2%)                                                          
      Vein, Dilatation                                 1 (2%)                                                                       
   Mesentery                                          (1)          (2)                       (1)                                    
      Fat, Inflammation, Chronic Active                1 (100%)     2 (100%)                                                        
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Acinus, Atrophy                                  1 (2%)       3 (5%)       1 (2%)       2 (3%)                                
      Acinus, Karyomegaly                                           1 (2%)                                                          
      Duct, Cyst                                                    1 (2%)                    1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Acinus, Atrophy                                                                         1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acanthosis                                       1 (2%)                                 1 (2%)                                
      Acanthosis, Multifocal                                                     1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Submucosa, Developmental Malformation            2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Aortic Valve, Thrombosis                                      1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)                                                                       
      Ventricle Right, Thrombosis                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Ectopic Tissue                                                1 (2%)                                                          
      Hyperplasia                                      1 (2%)                    4 (7%)                                             
      Hypertrophy                                     30 (50%)     30 (50%)     26 (43%)     25 (42%)                               
      Vacuolization Cytoplasmic                                                               1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)                                 1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      3 (5%)       2 (3%)       1 (2%)                                             
   Parathyroid Gland                                  (59)         (58)         (56)         (57)                                   
      Cyst                                             2 (3%)       1 (2%)                                                          
   Pituitary Gland                                    (55)         (56)         (58)         (57)                                   
      Craniopharyngeal Duct, Cyst                                                             1 (2%)                                
      Pars Distalis, Cyst                                           1 (2%)       3 (5%)       2 (4%)                                
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Follicle, Cyst                                                3 (5%)       1 (2%)       1 (2%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)       2 (3%)       2 (3%)                                
   Preputial Gland                                    (55)         (49)         (54)         (51)                                   
      Inflammation, Chronic Active                     3 (5%)       2 (4%)       4 (7%)       2 (4%)                                
      Duct, Dilatation                                27 (49%)     14 (29%)     16 (30%)     19 (37%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Spermatocele                                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                                             2 (3%)                                             
      Seminiferous Tubule, Atrophy                     2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
      Seminiferous Tubule, Mineralization                                                     2 (3%)                                
      Tunic, Inflammation, Chronic                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (59)         (57)         (57)         (58)                                   
      Depletion Lymphoid                               1 (2%)                                                                       
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (58)         (55)         (58)         (55)                                   
      Congestion                                       1 (2%)       1 (2%)                                                          
      Depletion Lymphoid                               2 (3%)                                 3 (5%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Histiocytic, Macrophage            48 (83%)     37 (67%)     44 (76%)     45 (82%)                               
      Infiltration Cellular, Histiocyte                3 (5%)       6 (11%)      9 (16%)      8 (15%)                               
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Depletion Lymphoid                               1 (2%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 5 (8%)       3 (5%)       4 (7%)       5 (8%)                                
      Hemorrhage                                                                              1 (2%)                                
   Thymus                                             (56)         (56)         (56)         (54)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             1 (2%)                                 1 (2%)                                
      Depletion Lymphoid                              12 (21%)      6 (11%)      2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                 1 (2%)                                
      Thoracic, Ulcer                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (58)                                   
      Maxilla, Inflammation, Chronic Active,                                                                                        
          Necrotizing                                                            1 (2%)                                             
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Diaphragm, Degeneration, Chronic                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                                (1)                       (1)                                    
      Sciatic, Axon, Degeneration                                   1 (100%)                                                        
   Spinal Cord                                                     (1)                                                              
      Axon, Degeneration                                            1 (100%)                                                        
      Lumbar, Axon, Nerve, Degeneration                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (3%)       4 (7%)       2 (3%)       3 (5%)                                
      Alveolar Epithelium, Hyperplasia, Macrophage                               1 (2%)                                             
      Alveolus, Hyperplasia, Macrophage                1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   4 (7%)       5 (8%)       7 (12%)     10 (17%)                               
      Subpleura, Infiltration Cellular, Lymphocyte                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (1)                                                 
      Atrophy                                                                    1 (100%)                                           
      Cornea, Hyperplasia, Squamous                    1 (50%)      2 (100%)                                                        
      Cornea, Inflammation, Chronic Active             1 (50%)      2 (100%)                                                        
   Harderian Gland                                    (3)          (4)          (3)                                                 
      Hyperplasia                                                   1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05165-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/09/95  
Route: DOSED FEED                                                                                                 Time: 20:28:46  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Nephropathy, Chronic                            56 (93%)     55 (92%)     60 (100%)    56 (93%)                               
      Cortex, Cyst                                                  1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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