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TDMS Study 05165-02 Pathology Tables

NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95
Route: DOSED FEED                                                                                                 Time: 16:17:28




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-69-5

       Lock Date:  01/10/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                  9            9           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            9           11           11                                     
    Moribund Sacrifice                                 4            3            3            4                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                39           38           36           35                                     
  Missing                                                           1                                                               

  Animals Examined Microscopically                    60           59           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (59)         (60)         (60)                                   
   Gallbladder                                        (59)         (57)         (58)         (57)                                   
   Intestine Large, Colon                             (59)         (59)         (60)         (60)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Large, Rectum                            (59)         (59)         (60)         (60)                                   
   Intestine Large, Cecum                             (59)         (59)         (60)         (60)                                   
   Intestine Small, Duodenum                          (59)         (59)         (60)         (60)                                   
   Intestine Small, Jejunum                           (59)         (59)         (60)         (60)                                   
      Serosa, Fibrosarcoma, Metastatic, Skin                        1 (2%)                                                          
   Liver                                              (60)         (59)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Fibrous Histiocytoma, Multiple, Metastatic,                                                                                   
           Mesentery                                                1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (5%)       7 (12%)      7 (12%)      4 (7%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                          14 (23%)     11 (19%)     11 (18%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                 6 (10%)      7 (12%)      7 (12%)      1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
   Mesentery                                          (5)          (6)          (4)          (1)                                    
      Fibrous Histiocytoma                                          1 (17%)                                                         
      Fat, Fibrosarcoma, Metastatic, Skin                           1 (17%)                                                         
      Fat, Granulosa-Theca Tumor Malignant,                                                                                         
          Metastatic, Ovary                            1 (20%)                                                                      
      Fat, Histiocytic Sarcoma, Metastatic, Uterus                               1 (25%)                                            
   Pancreas                                           (59)         (59)         (59)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
      Serosa, Fibrosarcoma, Metastatic, Skin                        1 (2%)                                                          

                                                             Page   2                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (60)         (59)         (57)         (60)                                   
   Stomach, Forestomach                               (59)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
      Squamous Cell Papilloma                          2 (3%)                                                                       
   Stomach, Glandular                                 (59)         (59)         (60)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (60)         (60)                                   
      Sarcoma, Metastatic, Kidney                                                             1 (2%)                                
      Capsule, Fibrosarcoma, Metastatic, Skin                       1 (2%)                                                          
      Capsule, Spindle Cell, Adenoma                                                          1 (2%)                                
      Spindle Cell, Subcapsular, Adenoma               1 (2%)                                 1 (2%)                                
   Adrenal Medulla                                    (58)         (59)         (60)         (60)                                   
      Pheochromocytoma Benign                                       2 (3%)       2 (3%)       2 (3%)                                
      Bilateral, Pheochromocytoma Malignant                         1 (2%)                                                          
   Pituitary Gland                                    (57)         (58)         (59)         (58)                                   
      Pars Distalis, Adenoma                           5 (9%)       6 (10%)      9 (15%)      4 (7%)                                
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Intermedia, Adenoma                                      1 (2%)                    1 (2%)                                
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (60)         (59)         (59)         (60)                                   
      Follicular Cell, Adenoma                                      1 (2%)       2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                    (1)                                    
      Fibrosarcoma                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (59)         (59)         (60)                                   
      Cystadenoma                                                   3 (5%)       3 (5%)       2 (3%)                                
      Granulosa-Theca Tumor Malignant                  1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             

                                                             Page   3                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Luteoma                                                       2 (3%)                                                          
      Sarcoma                                                                                 1 (2%)                                
      Teratoma Benign                                                                         2 (3%)                                
      Thecoma Benign                                   1 (2%)                                                                       
      Periovarian Tissue, Histiocytic Sarcoma                                    1 (2%)                                             
   Uterus                                             (60)         (59)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    3 (5%)                                             
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    2 (3%)                    1 (2%)                                             
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (60)         (60)                                   
      Femoral, Hemangiosarcoma                         1 (2%)       1 (2%)                                                          
   Lymph Node                                         (9)          (7)          (4)          (7)                                    
      Lumbar, Fibrous Histiocytoma, Metastatic,                                                                                     
           Uncertain Primary Site                                                1 (25%)                                            
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                     1 (14%)                                                         
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Uncertain Primary Site                                     1 (25%)                                            
      Mediastinal, Histiocytic Sarcoma                 1 (11%)                                                                      
      Pancreatic, Histiocytic Sarcoma                  1 (11%)                                                                      
      Pancreatic, Histiocytic Sarcoma, Metastatic,                                                                                  
           Uterus                                                                1 (25%)                                            
      Renal, Fibrous Histiocytoma, Metastatic,                                                                                      
           Uncertain Primary Site                                                1 (25%)                                            
      Renal, Granulosa-Theca Tumor Malignant,                                                                                       
          Metastatic, Ovary                            1 (11%)                                1 (14%)                               
      Renal, Sarcoma, Metastatic, Kidney                                                      1 (14%)                               
   Lymph Node, Mandibular                             (59)         (59)         (57)         (60)                                   
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                              1 (2%)                                
   Lymph Node, Mesenteric                             (52)         (51)         (51)         (52)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                              1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
   Spleen                                             (60)         (59)         (60)         (59)                                   
      Hemangiosarcoma                                  2 (3%)       1 (2%)       1 (2%)                                             
   Thymus                                             (55)         (52)         (54)         (58)                                   

                                                             Page   4                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (59)         (58)         (59)                                   
      Adenocarcinoma, Multiple                                      1 (2%)                                                          
   Skin                                               (60)         (59)         (60)         (60)                                   
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)       2 (3%)       3 (5%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma,                                                                                            
          Metastatic, Skin                                          1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma,                                                                                    
           Metastatic, Uncertain Primary Site                                    1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                  2 (3%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (59)         (60)         (60)                                   
      Diaphragm, Fibrous Histiocytoma, Metastatic,                                                                                  
           Mesentery                                                1 (2%)                                                          
      Diaphragm, Granulosa-Theca Tumor Malignant,                                                                                   
           Metastatic, Ovary                           1 (2%)                                                                       
      Thigh, Fibrosarcoma, Metastatic, Skin            1 (2%)       1 (2%)                                                          
      Thigh, Histiocytic Sarcoma, Metastatic,                                                                                       
          Uterus                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Meninges, Cerebrum, Lipoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       3 (5%)       1 (2%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                                1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Mesentery                   1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                       1 (2%)                                                                       

                                                             Page   5                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       3 (5%)       3 (5%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (2)          (1)                                    
      Adenoma                                                                    1 (50%)                                            
      Pinna, Fibroma                                                             1 (50%)                                            
   Eye                                                (1)          (1)                       (1)                                    
      Adenocarcinoma, Metastatic, Harderian Gland      1 (100%)                                                                     
   Harderian Gland                                    (1)          (3)          (1)          (1)                                    
      Adenocarcinoma                                   1 (100%)     2 (67%)                                                         
      Adenoma                                                       1 (33%)      1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
      Sarcoma                                                                                 1 (2%)                                
   Urinary Bladder                                    (59)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(59)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                    4 (7%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Lymphoma Malignant Lymphocytic                   3 (5%)       2 (3%)       5 (8%)       5 (8%)                                
      Lymphoma Malignant Mixed                         7 (12%)      4 (7%)       4 (7%)       1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell         2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        250 PPM      500 PPM      1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          38          39          41                                       
     Total Primary Neoplasms                           64          65          66          48                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          31          25          25                                       
     Total Benign Neoplasms                            37          38          39          29                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          22          23          18                                       
     Total Malignant Neoplasms                         27          27          27          19                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           6           6           2                                       
     Total Metastatic Neoplasm                          8          16          21           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            6            1            4                                     
    Moribund Sacrifice                                 2            2                         1                                     
  Survivors                                                                                                                         
    Natural Death                                      1            1                                                               
    Terminal Sacrifice                                41           41           49           45                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (59)         (60)         (59)                                   
   Intestine Small, Duodenum                          (60)         (59)         (59)         (60)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatocellular Carcinoma                         8 (13%)      9 (15%)      7 (12%)      3 (5%)                                
      Hepatocellular Carcinoma, Multiple               3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
      Hepatocellular Adenoma                          11 (18%)     13 (22%)     20 (33%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                 6 (10%)     11 (18%)      6 (10%)      4 (7%)                                
   Mesentery                                          (1)          (2)                       (1)                                    
   Pancreas                                           (60)         (60)         (60)         (60)                                   
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Bilateral, Spindle Cell, Subcapsular, Adenoma                 1 (2%)       1 (2%)                                             
      Capsule, Spindle Cell, Adenoma                                             1 (2%)                                             
      Spindle Cell, Subcapsular, Adenoma              11 (18%)      6 (10%)      6 (10%)      6 (10%)                               
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   

                                                             Page   8                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Malignant                                                 1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (55)         (56)         (58)         (57)                                   
      Pars Distalis, Adenoma                                                     1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      C-Cell, Adenoma                                  1 (2%)                                                                       
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (60)         (60)         (60)         (60)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (58)                                   
      Femoral, Hemangiosarcoma                         1 (2%)                                 1 (2%)                                
   Lymph Node                                                      (1)          (1)          (2)                                    
      Inguinal, Hemangioma                                          1 (100%)                                                        
   Lymph Node, Mandibular                             (59)         (57)         (57)         (58)                                   
   Lymph Node, Mesenteric                             (58)         (55)         (58)         (55)                                   
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
   Thymus                                             (56)         (56)         (56)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

                                                             Page   9                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Harderian Gland      2 (3%)                                                                       
      Alveolar/Bronchiolar Adenoma                     5 (8%)       7 (12%)      9 (15%)      3 (5%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       2 (3%)       1 (2%)                                             
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (5%)       4 (7%)       4 (7%)       1 (2%)                                
   Nose                                               (60)         (60)         (60)         (58)                                   
      Adenocarcinoma, Metastatic, Harderian Gland      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (1)                                                 
      Pinna, Fibroma                                   1 (100%)                                                                     
      Pinna, Trichoepithelioma                                                   1 (100%)                                           
   Eye                                                (2)          (2)          (1)                                                 
      Adenocarcinoma, Metastatic, Harderian Gland      1 (50%)                                                                      
   Harderian Gland                                    (3)          (4)          (3)                                                 
      Adenocarcinoma                                   2 (67%)                   1 (33%)                                            
      Adenoma                                          1 (33%)      3 (75%)      2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Artery, Fibrosarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant Histiocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Mixed                                      2 (3%)       3 (5%)       3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell                                                1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05165-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:17:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        250 PPM      500  PPM     1000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          41          45          27                                       
     Total Primary Neoplasms                           62          61          67          36                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          32          38          20                                       
     Total Benign Neoplasms                            41          45          49          23                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          15          16          11                                       
     Total Malignant Neoplasms                         21          16          18          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           5           4           1                                       
     Total Metastatic Neoplasm                          7           7           4           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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