TDMS Study 05165-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 02 TIME: 20:39:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: R. PERSING CAS: 96-69-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 02 TIME: 20:39:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: R. PERSING CAS: 96-69-5
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 02 TIME: 20:39:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: R. PERSING CAS: 96-69-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
Cell Type
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Ovary Teratoma Benign
All Organs Hemangiosarcoma or Hemangioma
====================================================================================================
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 7/60 (12%) 8/60 (13%) 6/60 (10%) | 1/60 (2%) 0/59 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 25.3% 16.7% 15.7% 13.0% | 2.5% 0.0% 0.0% 4.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 10/42 (24%) 7/42 (17%) 7/49 (14%) 5/45 (11%) | 1/40 (3%) 0/38 (0%) 0/36 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 508 729 (T) 456 (I) 724 | 729 (T) --- --- 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.109N P=0.219N P=0.203N P=0.116N | P=0.237 P=0.510N P=0.521N P=0.481 |
|INCIDENTAL TUMOR | P=0.150N P=0.192N P=0.275N P=0.192N | P=0.237 P=0.510N P=0.521N P=0.481 |
|LOGISTIC REGRESSION | P=0.130N P=0.236N P=0.284N P=0.131N | P=0.252 P=0.510N P=0.521N P=0.504 |
|COCHRAN-ARMITAGE | P=0.152N | P=0.247 |
|FISHER EXACT | P=0.222N P=0.309N P=0.148N | P=0.504N P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/58 (0%) 2/59 (3%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 5.3% 5.6% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 0/49 (0%) 0/45 (0%) | 0/38 (0%) 2/38 (5%) 2/36 (6%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.214 P=0.238 P=0.226 P=0.220 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.214 P=0.238 P=0.226 P=0.220 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.214 P=0.238 P=0.226 P=0.220 |
|COCHRAN-ARMITAGE | (e) | P=0.252 |
|FISHER EXACT | (e) (e) (e) | P=0.252 P=0.256 P=0.256 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/58 (0%) 3/59 (5%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 2.0% 0.0% | 0.0% 6.9% 5.6% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 1/49 (2%) 0/45 (0%) | 0/38 (0%) 2/38 (5%) 2/36 (6%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- | --- 450 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.707 (e) P=0.531 (e) | P=0.297 P=0.125 P=0.226 P=0.220 |
|INCIDENTAL TUMOR | P=0.707 (e) P=0.531 (e) | P=0.186 P=0.084 P=0.226 P=0.220 |
|LOGISTIC REGRESSION | P=0.707 (e) P=0.531 (e) | P=0.325 P=0.118 P=0.226 P=0.220 |
|COCHRAN-ARMITAGE | P=0.694 | P=0.337 |
|FISHER EXACT | (e) P=0.500 (e) | P=0.125 P=0.256 P=0.256 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 1/59 (2%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 2.4% 7.1% 4.1% 0.0% | 0.0% 2.6% 2.6% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/42 (2%) 3/42 (7%) 2/49 (4%) 0/45 (0%) | 0/40 (0%) 0/38 (0%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) --- | --- 723 701 565 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.216N P=0.305 P=0.554 P=0.486N | P=0.360 P=0.490 P=0.481 P=0.504 |
|INCIDENTAL TUMOR | P=0.216N P=0.305 P=0.554 P=0.486N | P=0.522 P=0.669 P=0.695 P=0.581 |
|LOGISTIC REGRESSION | P=0.215N P=0.305 P=0.554 P=0.486N | P=0.384 P=0.500 P=0.498 P=0.522 |
|COCHRAN-ARMITAGE | P=0.242N | P=0.386 |
|FISHER EXACT | P=0.309 P=0.500 P=0.500N | P=0.496 P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 2/59 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.5% 0.0% 2.0% 0.0% | 2.5% 5.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/42 (2%) 0/42 (0%) 1/49 (2%) 0/45 (0%) | 1/40 (3%) 2/38 (5%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 683 --- 729 (T) --- | 729 (T) 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175N P=0.247N P=0.457N P=0.230N | P=0.211N P=0.482 P=0.521N P=0.527N |
|INCIDENTAL TUMOR | P=0.233N P=0.314N P=0.640N P=0.305N | P=0.211N P=0.482 P=0.521N P=0.527N |
|LOGISTIC REGRESSION | P=0.181N P=0.242N P=0.484N P=0.234N | P=0.211N P=0.482 P=0.521N P=0.527N |
|COCHRAN-ARMITAGE | P=0.188N | P=0.188N |
|FISHER EXACT | P=0.248N P=0.500N P=0.248N | P=0.494 P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 3/60 (5%) 0/60 (0%) | 1/60 (2%) 3/59 (5%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 6.8% 7.1% 6.1% 0.0% | 2.5% 7.7% 2.6% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/42 (5%) 3/42 (7%) 3/49 (6%) 0/45 (0%) | 1/40 (3%) 2/38 (5%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 683 729 (T) 729 (T) --- | 729 (T) 723 701 565 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077N P=0.656 P=0.596N P=0.114N | P=0.487N P=0.289 P=0.738 P=0.748 |
|INCIDENTAL TUMOR | P=0.096N P=0.610 P=0.615 P=0.153N | P=0.370N P=0.364 P=0.673N P=0.732N |
|LOGISTIC REGRESSION | P=0.081N P=0.651 P=0.633N P=0.116N | P=0.457N P=0.296 P=0.757 P=0.762N |
|COCHRAN-ARMITAGE | P=0.093N | P=0.442N |
|FISHER EXACT | P=0.660N P=0.660N P=0.122N | P=0.303 P=0.752N P=0.752N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/60 (28%) 24/60 (40%) 26/60 (43%) 14/60 (23%) | 20/60 (33%) 18/59 (31%) 18/60 (30%) 11/60 (18%) |
|ADJUSTED (b) | 39.5% 52.7% 48.6% 29.1% | 45.5% 45.7% 48.1% 29.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 4/10 (40%) 2/10 (20%) | 3/9 (33%) 1/9 (11%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 16/42 (38%) 21/42 (50%) 22/49 (45%) 12/45 (27%) | 17/40 (43%) 17/38 (45%) 17/36 (47%) 10/35 (29%) |
|FIRST INCIDENCE (DAYS) | 690 456 (I) 456 (I) 456 (I) | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.123N P=0.113 P=0.165 P=0.262N | P=0.067N P=0.489N P=0.549N P=0.080N |
|INCIDENTAL TUMOR | P=0.132N P=0.119 P=0.129 P=0.287N | P=0.067N P=0.489N P=0.549N P=0.080N |
|LOGISTIC REGRESSION | P=0.181N P=0.094 P=0.075 P=0.310N | P=0.046N* P=0.407N P=0.430N P=0.054N |
|COCHRAN-ARMITAGE | P=0.210N | P=0.036N* |
|FISHER EXACT | P=0.124 P=0.064 P=0.339N | P=0.447N P=0.422N P=0.047N* |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 11/60 (18%) 10/60 (17%) 4/60 (7%) | 4/60 (7%) 8/59 (14%) 7/60 (12%) 5/60 (8%) |
|ADJUSTED (b) | 24.2% 22.7% 19.4% 8.6% | 9.8% 20.1% 18.2% 12.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/42 (19%) 5/42 (12%) 8/49 (16%) 3/45 (7%) | 3/40 (8%) 7/38 (18%) 5/36 (14%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | 620 489 456 (I) 638 | 724 521 661 551 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.026N* P=0.577 P=0.374N P=0.041N* | P=0.466 P=0.159 P=0.213 P=0.426 |
|INCIDENTAL TUMOR | P=0.059N P=0.517N P=0.509 P=0.034N* | P=0.499 P=0.163 P=0.363 P=0.584 |
|LOGISTIC REGRESSION | P=0.056N P=0.591 P=0.495 P=0.043N* | P=0.519 P=0.182 P=0.238 P=0.473 |
|COCHRAN-ARMITAGE | P=0.033N* | P=0.553N |
|FISHER EXACT | P=0.593N P=0.500N P=0.048N* | P=0.173 P=0.264 P=0.500 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 32/60 (53%) 31/60 (52%) 18/60 (30%) | 23/60 (38%) 24/59 (41%) 25/60 (42%) 15/60 (25%) |
|ADJUSTED (b) | 55.4% 63.6% 57.1% 36.9% | 51.5% 59.5% 63.7% 38.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 4/10 (40%) 2/10 (20%) | 3/9 (33%) 1/9 (11%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 22/42 (52%) 24/42 (57%) 26/49 (53%) 15/45 (33%) | 19/40 (48%) 22/38 (58%) 22/36 (61%) 12/35 (34%) |
|FIRST INCIDENCE (DAYS) | 620 456 (I) 456 (I) 456 (I) | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024N* P=0.139 P=0.416 P=0.081N | P=0.122N P=0.415 P=0.271 P=0.157N |
|INCIDENTAL TUMOR | P=0.047N* P=0.159 P=0.196 P=0.076N | P=0.108N P=0.421 P=0.374 P=0.106N |
|LOGISTIC REGRESSION | P=0.040N* P=0.105 P=0.212 P=0.104N | P=0.071N P=0.518 P=0.409 P=0.097N |
|COCHRAN-ARMITAGE | P=0.052N | P=0.056N |
|FISHER EXACT | P=0.136 P=0.180 P=0.127N | P=0.470 P=0.426 P=0.085N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 32/60 (53%) 31/60 (52%) 18/60 (30%) | 23/60 (38%) 24/59 (41%) 25/60 (42%) 15/60 (25%) |
|ADJUSTED (b) | 55.4% 63.6% 57.1% 36.9% | 51.5% 59.5% 63.7% 38.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 4/10 (40%) 2/10 (20%) | 3/9 (33%) 1/9 (11%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 22/42 (52%) 24/42 (57%) 26/49 (53%) 15/45 (33%) | 19/40 (48%) 22/38 (58%) 22/36 (61%) 12/35 (34%) |
|FIRST INCIDENCE (DAYS) | 620 456 (I) 456 (I) 456 (I) | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024N* P=0.139 P=0.416 P=0.081N | P=0.122N P=0.415 P=0.271 P=0.157N |
|INCIDENTAL TUMOR | P=0.047N* P=0.159 P=0.196 P=0.076N | P=0.108N P=0.421 P=0.374 P=0.106N |
|LOGISTIC REGRESSION | P=0.040N* P=0.105 P=0.212 P=0.104N | P=0.071N P=0.518 P=0.409 P=0.097N |
|COCHRAN-ARMITAGE | P=0.052N | P=0.056N |
|FISHER EXACT | P=0.136 P=0.180 P=0.127N | P=0.470 P=0.426 P=0.085N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 8/60 (13%) 9/60 (15%) 3/60 (5%) | 2/60 (3%) 3/59 (5%) 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | 15.1% 18.1% 17.7% 6.7% | 5.0% 7.6% 2.8% 7.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/42 (10%) 7/42 (17%) 8/49 (16%) 3/45 (7%) | 2/40 (5%) 2/38 (5%) 1/36 (3%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 729 (T) | 729 (T) 718 729 (T) 597 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097N P=0.497 P=0.504 P=0.142N | P=0.422 P=0.479 P=0.537N P=0.452 |
|INCIDENTAL TUMOR | P=0.123N P=0.427 P=0.339 P=0.196N | P=0.486 P=0.555 P=0.537N P=0.488 |
|LOGISTIC REGRESSION | P=0.119N P=0.491 P=0.405 P=0.156N | P=0.449 P=0.492 P=0.537N P=0.482 |
|COCHRAN-ARMITAGE | P=0.127N | P=0.480 |
|FISHER EXACT | P=0.500 P=0.395 P=0.161N | P=0.492 P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 7.0% 4.5% 2.0% 0.0% | 0.0% 0.0% 0.0% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/42 (5%) 0/42 (0%) 1/49 (2%) 0/45 (0%) | 0/40 (0%) 0/38 (0%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 712 661 729 (T) --- | --- --- --- 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054N P=0.504N P=0.256N P=0.111N | P=0.187 (e) (e) P=0.481 |
|INCIDENTAL TUMOR | P=0.113N P=0.692 P=0.390N P=0.153N | P=0.242 (e) (e) P=0.669 |
|LOGISTIC REGRESSION | P=0.058N P=0.510N P=0.276N P=0.113N | P=0.196 (e) (e) P=0.496 |
|COCHRAN-ARMITAGE | P=0.062N | P=0.199 |
|FISHER EXACT | P=0.500N P=0.309N P=0.122N | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 10/60 (17%) 10/60 (17%) 3/60 (5%) | 2/60 (3%) 3/59 (5%) 1/60 (2%) 4/60 (7%) |
|ADJUSTED (b) | 19.5% 21.7% 19.7% 6.7% | 5.0% 7.6% 2.8% 10.2% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/42 (14%) 7/42 (17%) 9/49 (18%) 3/45 (7%) | 2/40 (5%) 2/38 (5%) 1/36 (3%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 729 (T) | 729 (T) 718 729 (T) 597 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033N* P=0.497 P=0.571N P=0.054N | P=0.245 P=0.479 P=0.537N P=0.293 |
|INCIDENTAL TUMOR | P=0.055N P=0.366 P=0.472 P=0.078N | P=0.321 P=0.555 P=0.537N P=0.389 |
|LOGISTIC REGRESSION | P=0.042N* P=0.487 P=0.520 P=0.060N | P=0.268 P=0.492 P=0.537N P=0.320 |
|COCHRAN-ARMITAGE | P=0.048N* | P=0.295 |
|FISHER EXACT | P=0.500 P=0.500 P=0.063N | P=0.492 P=0.500N P=0.340 |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/59 (0%) 3/59 (5%) 3/59 (5%) 2/60 (3%) |
|ADJUSTED (b) | | 0.0% 7.9% 8.6% 5.4% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/39 (0%) 3/38 (8%) 3/35 (9%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 729 (T) 729 (T) 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.270 P=0.116 P=0.102 P=0.215 |
|INCIDENTAL TUMOR | | P=0.298 P=0.116 P=0.102 P=0.315 |
|LOGISTIC REGRESSION | | P=0.278 P=0.116 P=0.102 P=0.231 |
|COCHRAN-ARMITAGE | | P=0.320 |
|FISHER EXACT | | P=0.122 P=0.122 P=0.252 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Luteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/59 (0%) 2/59 (3%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 4.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/39 (0%) 1/38 (3%) 0/35 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 450 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.416N P=0.241 (e) (e) |
|INCIDENTAL TUMOR | | P=0.674N P=0.164 (e) (e) |
|LOGISTIC REGRESSION | | P=0.381N P=0.214 (e) (e) |
|COCHRAN-ARMITAGE | | P=0.402N |
|FISHER EXACT | | P=0.248 (e) (e) |
|=================================================================================================================================|
| |
|Ovary |
| Teratoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/59 (0%) 0/59 (0%) 0/59 (0%) 2/60 (3%) |
|ADJUSTED (b) | | 0.0% 0.0% 0.0% 3.3% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/39 (0%) 0/38 (0%) 0/35 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | | --- --- --- 113 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.047 * (e) (e) P=0.238 |
|INCIDENTAL TUMOR | | P=0.362 (e) (e) (e) |
|LOGISTIC REGRESSION | | P=0.170 (e) (e) (e) |
|COCHRAN-ARMITAGE | | P=0.048 * |
|FISHER EXACT | | (e) (e) P=0.252 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/55 (0%) 0/56 (0%) 1/58 (2%) 0/57 (0%) | 6/57 (11%) 6/58 (10%) 9/59 (15%) 4/58 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 2.1% 0.0% | 14.4% 14.8% 22.9% 11.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/40 (0%) 1/48 (2%) 0/44 (0%) | 5/40 (13%) 4/38 (11%) 7/36 (19%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- | 612 697 568 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.711 (e) P=0.536 (e) | P=0.441N P=0.587 P=0.238 P=0.450N |
|INCIDENTAL TUMOR | P=0.711 (e) P=0.536 (e) | P=0.347N P=0.593N P=0.266 P=0.381N |
|LOGISTIC REGRESSION | P=0.711 (e) P=0.536 (e) | P=0.397N P=0.616N P=0.276 P=0.412N |
|COCHRAN-ARMITAGE | P=0.699 | P=0.335N |
|FISHER EXACT | (e) P=0.513 (e) | P=0.607N P=0.316 P=0.360N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 2/59 (3%) 3/60 (5%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.1% 5.1% 7.7% 2.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 0/49 (0%) 0/45 (0%) | 1/40 (3%) 1/38 (3%) 2/36 (6%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 369 718 655 701 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.453N P=0.679 P=0.472 P=0.537N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.457N P=0.696N P=0.442 P=0.689N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.408N P=0.679 P=0.502 P=0.482N |
|COCHRAN-ARMITAGE | (e) | P=0.402N |
|FISHER EXACT | (e) (e) (e) | P=0.684 P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 0/49 (0%) 0/45 (0%) | 1/40 (3%) 0/38 (0%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 622 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.122N P=0.243N P=0.246N P=0.257N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.103N P=0.277N P=0.251N P=0.209N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.116N P=0.239N P=0.239N P=0.242N |
|COCHRAN-ARMITAGE | (e) | P=0.115N |
|FISHER EXACT | (e) (e) (e) | P=0.252N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 1/60 (2%) | 2/60 (3%) 1/59 (2%) 1/60 (2%) 0/59 (0%) |
|ADJUSTED (b) | 2.4% 2.4% 0.0% 2.1% | 5.0% 2.6% 2.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/42 (2%) 1/42 (2%) 0/49 (0%) 0/45 (0%) | 2/40 (5%) 1/38 (3%) 1/36 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- 701 | 729 (T) 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.593N P=0.762 P=0.469N P=0.743N | P=0.176N P=0.518N P=0.537N P=0.268N |
|INCIDENTAL TUMOR | P=0.635 P=0.762 P=0.469N P=0.695 | P=0.176N P=0.518N P=0.537N P=0.268N |
|LOGISTIC REGRESSION | P=0.604N P=0.762 P=0.469N P=0.756N | P=0.176N P=0.518N P=0.537N P=0.268N |
|COCHRAN-ARMITAGE | P=0.616N | P=0.155N |
|FISHER EXACT | P=0.752N P=0.500N P=0.752N | P=0.506N P=0.500N P=0.252N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 2/60 (3%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 2.0% 0.0% | 5.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 1/49 (2%) 0/45 (0%) | 2/40 (5%) 0/38 (0%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 690 --- 729 (T) --- | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.387N P=0.505N P=0.731N P=0.487N | P=0.128N P=0.250N P=0.262N P=0.268N |
|INCIDENTAL TUMOR | P=0.481N P=0.638N P=0.617 P=0.638N | P=0.128N P=0.250N P=0.262N P=0.268N |
|LOGISTIC REGRESSION | P=0.398N P=0.502N P=0.754N P=0.498N | P=0.128N P=0.250N P=0.262N P=0.268N |
|COCHRAN-ARMITAGE | P=0.405N | P=0.115N |
|FISHER EXACT | P=0.500N P=0.752N P=0.500N | P=0.252N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 1/59 (2%) 2/59 (3%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 2.0% 0.0% | 0.0% 2.6% 5.6% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 1/49 (2%) 0/45 (0%) | 0/40 (0%) 1/38 (3%) 2/36 (6%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.707 (e) P=0.531 (e) | P=0.329 P=0.490 P=0.215 P=0.473 |
|INCIDENTAL TUMOR | P=0.707 (e) P=0.531 (e) | P=0.329 P=0.490 P=0.215 P=0.473 |
|LOGISTIC REGRESSION | P=0.707 (e) P=0.531 (e) | P=0.329 P=0.490 P=0.215 P=0.473 |
|COCHRAN-ARMITAGE | P=0.694 | P=0.368 |
|FISHER EXACT | (e) P=0.500 (e) | P=0.496 P=0.244 P=0.500 |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/60 (3%) 0/59 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | | 5.0% 0.0% 2.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/40 (5%) 0/38 (0%) 1/36 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.211N P=0.250N P=0.537N P=0.268N |
|INCIDENTAL TUMOR | | P=0.211N P=0.250N P=0.537N P=0.268N |
|LOGISTIC REGRESSION | | P=0.211N P=0.250N P=0.537N P=0.268N |
|COCHRAN-ARMITAGE | | P=0.188N |
|FISHER EXACT | | P=0.252N P=0.500N P=0.248N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/60 (3%) 0/59 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 5.0% 0.0% 5.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/40 (5%) 0/38 (0%) 1/36 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- 701 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.280N P=0.250N P=0.656 P=0.268N |
|INCIDENTAL TUMOR | | P=0.236N P=0.250N P=0.643N P=0.268N |
|LOGISTIC REGRESSION | | P=0.267N P=0.250N P=0.680 P=0.268N |
|COCHRAN-ARMITAGE | | P=0.247N |
|FISHER EXACT | | P=0.252N P=0.691N P=0.248N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.4% 2.2% 0.0% 0.0% | 4.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/42 (2%) 0/42 (0%) 0/49 (0%) 0/45 (0%) | 1/40 (3%) 0/38 (0%) 0/36 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 661 --- --- | 622 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.224N P=0.758 P=0.469N P=0.486N | P=0.122N P=0.243N P=0.246N P=0.257N |
|INCIDENTAL TUMOR | P=0.305N P=0.686 P=0.469N P=0.486N | P=0.103N P=0.277N P=0.251N P=0.209N |
|LOGISTIC REGRESSION | P=0.233N P=0.759 P=0.469N P=0.486N | P=0.116N P=0.239N P=0.239N P=0.242N |
|COCHRAN-ARMITAGE | P=0.236N | P=0.115N |
|FISHER EXACT | P=0.752N P=0.500N P=0.500N | P=0.252N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 2/60 (3%) | 2/60 (3%) 2/59 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.4% 2.4% 0.0% 4.3% | 5.0% 5.3% 2.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/42 (2%) 1/42 (2%) 0/49 (0%) 1/45 (2%) | 2/40 (5%) 2/38 (5%) 1/36 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- 701 | 729 (T) 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 P=0.762 P=0.469N P=0.526 | P=0.148N P=0.676 P=0.537N P=0.268N |
|INCIDENTAL TUMOR | P=0.332 P=0.762 P=0.469N P=0.438 | P=0.148N P=0.676 P=0.537N P=0.268N |
|LOGISTIC REGRESSION | P=0.382 P=0.762 P=0.469N P=0.512 | P=0.148N P=0.676 P=0.537N P=0.268N |
|COCHRAN-ARMITAGE | P=0.367 | P=0.125N |
|FISHER EXACT | P=0.752N P=0.500N P=0.500 | P=0.684 P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 0/60 (0%) 2/60 (3%) | 4/60 (7%) 2/59 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 4.8% 4.6% 0.0% 4.3% | 9.6% 5.3% 2.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/42 (5%) 1/42 (2%) 0/49 (0%) 1/45 (2%) | 3/40 (8%) 2/38 (5%) 1/36 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 661 --- 701 | 622 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.524N P=0.691 P=0.205N P=0.666N | P=0.038N* P=0.356N P=0.205N P=0.079N |
|INCIDENTAL TUMOR | P=0.588 P=0.634 P=0.205N P=0.653 | P=0.033N* P=0.380N P=0.208N P=0.064N |
|LOGISTIC REGRESSION | P=0.542N P=0.686 P=0.205N P=0.682N | P=0.033N* P=0.334N P=0.184N P=0.068N |
|COCHRAN-ARMITAGE | P=0.556N | P=0.030N* |
|FISHER EXACT | P=0.691N P=0.248N P=0.691N | P=0.348N P=0.182N P=0.059N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 1/60 (2%) 0/59 (0%) 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.3% 0.0% 9.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/42 (0%) 0/49 (0%) 0/45 (0%) | 0/40 (0%) 0/38 (0%) 1/36 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 705 --- 457 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.558N P=0.509N P=0.172 P=0.541N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.423N P=0.331N P=0.302 P=0.331N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.524N P=0.499N P=0.181 P=0.509N |
|COCHRAN-ARMITAGE | (e) | P=0.528N |
|FISHER EXACT | (e) (e) (e) | P=0.504N P=0.182 P=0.500N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 3/60 (5%) 6/60 (10%) | 13/60 (22%) 7/59 (12%) 11/60 (18%) 8/60 (13%) |
|ADJUSTED (b) | 4.8% 4.8% 5.7% 12.7% | 31.7% 16.7% 26.6% 19.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/42 (5%) 2/42 (5%) 2/49 (4%) 4/45 (9%) | 12/40 (30%) 4/38 (11%) 7/36 (19%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 456 (I) 670 | 712 599 497 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.070 P=0.695 P=0.556 P=0.162 | P=0.333N P=0.133N P=0.509N P=0.257N |
|INCIDENTAL TUMOR | P=0.049 * P=0.695 P=0.556 P=0.099 | P=0.217N P=0.078N P=0.428N P=0.131N |
|LOGISTIC REGRESSION | P=0.060 P=0.695 P=0.499 P=0.146 | P=0.184N P=0.102N P=0.424N P=0.196N |
|COCHRAN-ARMITAGE | P=0.056 | P=0.226N |
|FISHER EXACT | P=0.691N P=0.500 P=0.136 | P=0.118N P=0.410N P=0.168N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 31/60 (52%) 32/60 (53%) 38/60 (63%) 20/60 (33%) | 30/60 (50%) 31/59 (53%) 25/60 (42%) 25/60 (42%) |
|ADJUSTED (b) | 67.1% 67.5% 70.1% 41.2% | 66.1% 70.1% 61.8% 57.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 3/10 (30%) 5/10 (50%) 2/10 (20%) | 3/9 (33%) 1/9 (11%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 27/42 (64%) 27/42 (64%) 33/49 (67%) 17/45 (38%) | 25/40 (63%) 25/38 (66%) 21/36 (58%) 18/35 (51%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 457 (I) 450 457 (I) 113 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006N** P=0.494 P=0.405 P=0.015N* | P=0.305N P=0.402 P=0.363N P=0.405N |
|INCIDENTAL TUMOR | P=0.012N* P=0.487 P=0.226 P=0.033N* | P=0.131N P=0.477 P=0.296N P=0.183N |
|LOGISTIC REGRESSION | P=0.009N** P=0.447 P=0.157 P=0.023N* | P=0.141N P=0.528 P=0.224N P=0.218N |
|COCHRAN-ARMITAGE | P=0.024N* | P=0.135N |
|FISHER EXACT | P=0.500 P=0.134 P=0.032N* | P=0.463 P=0.232N P=0.232N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 250 PPM 500 PPM 1000 PPM | 0 PPM 250 PPM 500 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 17/60 (28%) 15/60 (25%) 16/60 (27%) 11/60 (18%) | 23/60 (38%) 22/59 (37%) 24/60 (40%) 18/60 (30%) |
|ADJUSTED (b) | 36.1% 30.5% 30.4% 22.4% | 50.8% 48.2% 50.7% 39.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) | 0/9 (0%) 0/9 (0%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 12/42 (29%) 8/42 (19%) 13/49 (27%) 7/45 (16%) | 18/40 (45%) 15/38 (39%) 13/36 (36%) 8/35 (23%) |
|FIRST INCIDENCE (DAYS) | 620 489 456 (I) 638 | 369 450 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.438N P=0.337N P=0.116N | P=0.370N P=0.565N P=0.370 P=0.380N |
|INCIDENTAL TUMOR | P=0.235N P=0.423N P=0.444 P=0.170N | P=0.192N P=0.490N P=0.519N P=0.109N |
|LOGISTIC REGRESSION | P=0.201N P=0.442N P=0.475 P=0.218N | P=0.146N P=0.484N P=0.492 P=0.248N |
|COCHRAN-ARMITAGE | P=0.127N | P=0.194N |
|FISHER EXACT | P=0.418N P=0.500N P=0.140N | P=0.529N P=0.500 P=0.221N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 39/60 (65%) 41/60 (68%) 45/60 (75%) 27/60 (45%) | 41/60 (68%) 38/59 (64%) 40/60 (67%) 41/60 (68%) |
|ADJUSTED (b) | 79.5% 78.6% 80.2% 52.7% | 83.4% 80.6% 79.8% 78.5% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 3/10 (30%) 6/10 (60%) 2/10 (20%) | 3/9 (33%) 1/9 (11%) 2/10 (20%) 3/10 (30%) |
|TERMINAL (d) | 32/42 (76%) 31/42 (74%) 38/49 (78%) 21/45 (47%) | 32/40 (80%) 29/38 (76%) 26/36 (72%) 24/35 (69%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 369 450 457 (I) 113 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** P=0.416 P=0.546 P=0.012N* | P=0.214 P=0.475N P=0.427 P=0.310 |
|INCIDENTAL TUMOR | P=0.011N* P=0.429 P=0.134 P=0.023N* | P=0.505 P=0.362N P=0.412N P=0.332N |
|LOGISTIC REGRESSION | P=0.005N** P=0.361 P=0.186 P=0.013N* | P=0.415 P=0.297N P=0.493N P=0.577 |
|COCHRAN-ARMITAGE | P=0.009N** | P=0.482 |
|FISHER EXACT | P=0.423 P=0.160 P=0.022N* | P=0.398N P=0.500N P=0.578N |
|=================================================================================================================================|
DATE: 11/09/95 EXPERIMENT: 05165 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 457
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).