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TDMS Study 05165-02 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95       
EXPERIMENT: 05165 TEST: 02                                                                                     TIME: 20:41:50       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B       
PATHOLOGIST: R. PERSING                                                                                        CAS: 96-69-5         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95      
EXPERIMENT: 05165 TEST: 02                                                                                     TIME: 20:41:50      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B      
PATHOLOGIST: R. PERSING                                                                                        CAS: 96-69-5        
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 8      CENSORED DEATHS 10   TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      508   620   652   655   683   683   690   712                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 8      CENSORED DEATHS 10   TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      489   507   557   573   638   661   680   709                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500  PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 1      CENSORED DEATHS 10   TERMINAL 49        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      682                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 5      CENSORED DEATHS 10   TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      595   638   670   701   724                                               |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  92.0  84.0      |
 |           |                                                                    |
 |           |                                                                    |
 |250 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  92.0  88.0  84.0      |
 |           |                                                                    |
 |           |                                                                    |
 |500  PPM   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1000 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        250 PPM      500  PPM     1000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       84.0%        84.0%        98.0%        90.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.242N     P=1.000      P=0.036N     P=0.536N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       650.4        601.8        682.0        665.6    |
 |NATURAL DEATHS (C)      |       (22.6)       (29.0)       (  . )       (22.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       673.0        666.5        682.7        678.2    |
 |(STANDARD ERROR)        |       (13.4)       (13.9)       (13.2)       (13.2)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 9    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      369   369   386   522   564   593   612   622   705   712                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 12     CENSORED DEATHS 10   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      450   521   599   603   605   665   666   674   697   705                 |
 |      718   723                                                                 |
 |  CENSORED DEATHS                                                               |
 |      165   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      68    497   568   599   626   632   655   655   661   677                 |
 |      685   701   704   717                                                     |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      113   156   551   565   582   597   606   641   646   661                 |
 |      671   680   692   701   704                                               |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  95.0  95.0  93.0  89.1  85.1  79.2      |
 |           |                                                                    |
 |           |                                                                    |
 |250 PPM    |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  90.3  88.3  76.2      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |    98.3  98.3  98.3  98.3  98.3  98.3  96.3  92.3  82.3  72.2      |
 |           |                                                                    |
 |           |                                                                    |
 |1000 PPM   |   100.0  96.7  96.7  96.7  96.7  96.7  96.7  88.6  80.6  70.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        250 PPM      500 PPM      1000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       79.2%        76.2%        72.2%        70.5%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.346      P=1.000      P=0.651      P=0.468  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       561.6        635.5        603.2        571.1    |
 |NATURAL DEATHS (C)      |       (40.8)       (24.2)       (44.1)       (47.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       657.5        660.1        654.3        644.2    |
 |(STANDARD ERROR)        |       (15.5)       (15.8)       (16.6)       (18.1)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        250 PPM          = 2
                                                        500  PPM         = 3
                                                        1000 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                            2  1             4             3
      |
      |
      |
   98 +                                                                              2  1             4   1  4      3       3
      |
      |
      |
P  96 +                                                                                 2       2         1  4 1  4
E     |
R     |
C     |
E  94 +                                                                                         2 2               4    4
N     |
T     |
      |
S  92 +                                                                                           2          2 1    1  4  4
U     |
R     |
V     |
I  90 +                                                                                                      2   2        4 4
V     |
A     |
L     |
   88 +                                                                                                          2  11
      |
      |
      |
   86 +                                                                                                             21  1
      |
      |
      |
   84 +                                                                                                                 1   1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.
                                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        250 PPM          = 2
                                                        500 PPM          = 3
                                                        1000 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1          3       4                                      1             2
      |            3       4     4                                              2     3    2
      |
      |                          4                                1   1               3    2   4  3    2
P  95 +                                                               1                    1   4 4
E     |                                                                                           3    22
R     |                                                                                    1     1  4  3   3
C     |                                                                                          1  4 14
E  90 +                                                                                                 2  33    2
N     |                                                                                               1441  3  3 22
T     |                                                                                                  11
      |                                                                                                 4    4    22
S  85 +                                                                                                   1  44        1
U     |                                                                                                        3 3 2  211
R     |                                                                                                       4  3 3  22
V     |                                                                                                                 1 1
I  80 +                                                                                                          4433  2 2
V     |                                                                                                           4 3  3 21 1
A     |
L     |                                                                                                             44    2 2
   75 +                                                                                                              4 4
      |                                                                                                                3 3
      |                                                                                                                  3  3
      |
   70 +                                                                                                                4    4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95       
EXPERIMENT: 05165 TEST: 04                                                                                     TIME: 21:11:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B       
PATHOLOGIST: J. TOFT                                                                                           CAS: 96-69-5         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95      
EXPERIMENT: 05165 TEST: 04                                                                                     TIME: 21:11:17      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B      
PATHOLOGIST: J. TOFT                                                                                           CAS: 96-69-5        
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0 PPM     HCU                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      274   274   274   274   274   274   274   274   274   274                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 250 PPM   HCU                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      274   274   274   274   274   274   274   274   274   274                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 500 PPM   HCU                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      274   274   274   274   274   274   274   274   274   274                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1000 PPM   HCU                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      155   274   274   274   274   274   274   274   274   274                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   1E5 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM     HCU|                                                                    |
 |           |                                                                    |
 |250        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM   HCU  |                                                                    |
 |           |                                                                    |
 |500        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM   HCU  |                                                                    |
 |           |                                                                    |
 |1000       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM   HCU  |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0            250          500          1000     |
 |                                PPM     HCU  PPM   HCU    PPM   HCU    PPM   HCU|
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|      100.0%       100.0%       100.0%       100.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----        -----        -----        -----   |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |          .            .            .            .     |
 |NATURAL DEATHS (C)      |       (  . )       (  . )       (  . )       (  . )   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       183.3        183.3        183.3        177.3    |
 |(STANDARD ERROR)        |       (20.8)       (20.8)       (20.8)       (20.3)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0 PPM     HCU                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      275   275   275   275   275   275   275   275   275   275                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 250 PPM   HCU                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      275   275   275   275   275   275   275   275   275   275                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 500 PPM   HCU                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      275   275   275   275   275   275   275   275   275   275                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1000 PPM   HCU                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 20     UNCENSORED DEATHS 0      CENSORED DEATHS 20   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    93    93    93    93    93                  |
 |      275   275   275   275   275   275   275   275   275   275                 |
 |                                                                                |
 ==================================================================================
                         4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 99999 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   1E5 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM     HCU|                                                                    |
 |           |                                                                    |
 |250        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM   HCU  |                                                                    |
 |           |                                                                    |
 |500        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM   HCU  |                                                                    |
 |           |                                                                    |
 |1000       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |
 |PPM   HCU  |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0            250          500          1000     |
 |                                PPM     HCU  PPM   HCU    PPM   HCU    PPM   HCU|
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|      100.0%       100.0%       100.0%       100.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----        -----        -----        -----   |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |          .            .            .            .     |
 |NATURAL DEATHS (C)      |       (  . )       (  . )       (  . )       (  . )   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       183.8        183.8        183.8        183.8    |
 |(STANDARD ERROR)        |       (20.9)       (20.9)       (20.9)       (20.9)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM     HCU    = 1
                                                        250 PPM   HCU    = 2
                                                        500 PPM   HCU    = 3
                                                        1000 PPM   HCU   = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.
                         (NOTE: 6 obs hidden.)
                  P     |
                  E     |
                  R 200 +
                  C     |
                  E     |
                  N     |
                  T 100 +  1                                                                                  1
                        |
                  S     |
                  U     |
                  R   0 +
                  V     |
                  I     ---+----------------------------------------------------------------------------------+--
                  V        0                                                                                 40
                  A
                                                                   WEEK

                                                                                                                                    
                                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM     HCU    = 1
                                                        250 PPM   HCU    = 2
                                                        500 PPM   HCU    = 3
                                                        1000 PPM   HCU   = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.
                         (NOTE: 6 obs hidden.)
                  P     |
                  E     |
                  R 200 +
                  C     |
                  E     |
                  N     |
                  T 100 +  1                                                                                  1
                        |
                  S     |
                  U     |
                  R   0 +
                  V     |
                  I     ---+----------------------------------------------------------------------------------+--
                  V        0                                                                                 40
                  A
                                                                   WEEK