TDMS Study 05165-01 Pathology Tables
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-69-5
Lock Date: 12/26/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 11 14 16
Natural Death 5 5 2
Survivors
Terminal Sacrifice 34 30 32
Natural Death 1
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (10) (50) (10) (50) (10)
Parasite Metazoan 4 (8%) 4 (8%) 2 (4%)
Intestine Large, Rectum (50) (10) (50) (10) (50) (10)
Parasite Metazoan 5 (10%) 4 (8%) 3 (30%) 3 (6%) 2 (20%)
Intestine Large, Cecum (50) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Jejunum (50) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 1 (2%)
Liver (50) (10) (50) (10) (50) (10)
Angiectasis 1 (2%)
Basophilic Focus 37 (74%) 10 (100%) 34 (68%) 10 (100%) 38 (76%) 10 (100%)
Clear Cell Focus 1 (2%) 1 (2%)
Eosinophilic Focus 5 (10%) 7 (14%) 8 (16%) 1 (10%)
Fatty Change 9 (18%) 8 (16%) 15 (30%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 10 (20%) 2 (20%) 4 (8%) 1 (10%) 7 (14%) 6 (60%)
Inflammation, Chronic 22 (44%) 2 (20%) 21 (42%) 6 (60%) 18 (36%) 2 (20%)
Mixed Cell Focus 5 (10%) 4 (8%) 1 (10%) 14 (28%)
Necrosis, Coagulative 1 (2%)
Bile Duct, Hyperplasia 18 (36%) 1 (10%) 18 (36%) 3 (30%) 21 (42%) 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 12 (24%) 10 (20%) 1 (10%) 20 (40%) 1 (10%)
Periportal, Kupffer Cell, Hypertrophy 11 (22%) 1 (10%) 10 (20%) 9 (18%) 5 (50%)
Sinusoid, Dilatation 1 (2%)
Sinusoid, Ectasia 1 (10%)
Mesentery (9) (1) (7) (2) (8)
Ectopic Tissue 1 (13%)
Inflammation, Chronic Active 1 (100%) 2 (29%) 2 (100%)
Inflammation, Necrotizing 9 (100%) 4 (57%) 6 (75%)
Mineralization 5 (56%) 1 (13%)
Pancreas (50) (10) (50) (10) (50) (10)
Acinus, Atrophy 22 (44%) 4 (40%) 18 (36%) 5 (50%) 17 (34%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (10) (50) (10) (50) (10)
Acanthosis 1 (2%) 3 (6%) 4 (8%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%)
Stomach, Glandular (50) (10) (50) (10) (50) (10)
Erosion 3 (6%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Tooth (2) (1)
Gingiva, Inflammation, Chronic Active 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (10) (50) (10)
Cardiomyopathy, Chronic 41 (82%) 7 (70%) 37 (74%) 9 (90%) 41 (82%) 5 (50%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Coronary Artery, Necrosis, Fibrinoid 1 (2%)
Coronary Artery, Perivascular, Inflammation,
Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (10) (50) (10) (50) (10)
Degeneration, Fatty 20 (40%) 1 (10%) 20 (40%) 14 (28%)
Hematocyst 1 (2%)
Hyperplasia 11 (22%) 1 (10%) 16 (32%) 12 (24%)
Hypertrophy 2 (4%) 2 (4%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Adrenal Medulla (50) (10) (50) (10) (49) (10)
Hyperplasia 10 (20%) 7 (14%) 2 (4%)
Islets, Pancreatic (50) (10) (50) (10) (50) (10)
Hyperplasia 1 (2%)
Parathyroid Gland (48) (10) (48) (10) (46) (10)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (49) (10) (50) (10) (50) (10)
Pars Distalis, Cyst 24 (49%) 8 (80%) 29 (58%) 9 (90%) 22 (44%) 6 (60%)
Pars Distalis, Hyperplasia 17 (35%) 7 (70%) 19 (38%) 5 (50%) 18 (36%) 6 (60%)
Pars Intermedia, Cyst 3 (6%) 1 (2%)
Rathke's Cleft, Inflammation, Chronic Active 1 (10%)
Rathke's Cleft, Pigmentation, Hemosiderin 1 (10%)
Thyroid Gland (49) (10) (49) (10) (50) (10)
Infiltration Cellular, Lymphocyte 1 (2%)
C-Cell, Hyperplasia 28 (57%) 4 (40%) 24 (49%) 1 (10%) 27 (54%) 1 (10%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (10) (48) (10) (50) (10)
Hyperplasia 5 (10%) 6 (13%) 11 (22%)
Inflammation, Chronic Active 7 (14%) 2 (20%) 8 (17%) 5 (50%) 7 (14%) 1 (10%)
Duct, Dilatation 5 (10%) 1 (2%)
Ovary (50) (10) (50) (10) (50) (10)
Atrophy 1 (2%)
Cyst 14 (28%) 2 (20%) 10 (20%) 3 (30%) 12 (24%) 4 (40%)
Necrosis, Coagulative 1 (2%)
Uterus (50) (10) (50) (10) (50) (10)
Dilatation 3 (6%) 3 (6%) 2 (4%)
Diverticulum 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Cystic, Glandular 3 (6%) 5 (10%) 5 (10%)
Inflammation, Chronic Active 3 (6%) 2 (4%)
Vagina (2)
Exudate 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10) (50) (10) (50) (10)
Femoral, Myelofibrosis 1 (2%) 1 (2%) 1 (2%)
Lymph Node (14) (10) (10)
Mediastinal, Cyst 1 (7%)
Lymph Node, Mandibular (49) (10) (49) (10) (50) (10)
Cyst 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Sinus, Ectasia 1 (10%)
Spleen (50) (10) (50) (10) (50) (10)
Fibrosis 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Red Pulp, Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10) (50) (10) (50) (10)
Hyperplasia, Cystic 41 (82%) 10 (100%) 48 (96%) 10 (100%) 47 (94%) 10 (100%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Skin (50) (10) (50) (10) (50) (10)
Acanthosis 1 (2%)
Cyst Epithelial Inclusion 3 (6%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (10) (50) (10) (50) (10)
Cranium, Hyperostosis 1 (2%)
Femur, Osteopetrosis 1 (2%)
Skeletal Muscle (50) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 1 (2%)
Necrosis, Coagulative 2 (4%) 3 (30%) 3 (6%) 1 (10%) 3 (6%) 3 (30%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (10) (50) (10)
Compression 5 (10%) 4 (8%) 2 (4%)
Hemorrhage, Acute 2 (4%) 2 (4%)
Hydrocephalus 4 (8%) 4 (8%) 2 (4%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (2%)
Spinal Cord (1)
Compression 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (49) (10) (49) (10)
Inflammation, Chronic Active 12 (24%) 7 (70%) 12 (24%) 6 (60%) 12 (24%) 3 (30%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 1 (10%) 4 (8%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 33 (66%) 20 (41%) 26 (53%)
Artery, Mediastinum, Necrosis, Fibrinoid 1 (2%)
Artery, Mediastinum, Perivascular,
Inflammation, Chronic Active 1 (2%)
Nose (50) (10) (50) (10) (50) (10)
Fungus 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (10%) 1 (2%) 5 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 12 (24%) 3 (30%) 11 (22%) 15 (30%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Trachea (50) (10) (50) (10) (50) (10)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (3) (1) (1)
Lens, Cataract 2 (100%) 2 (100%) 3 (100%) 1 (100%) 1 (100%)
Retina, Atrophy 2 (100%) 2 (100%) 3 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (10) (50) (10)
Cyst 2 (4%)
Hydronephrosis 1 (2%)
Infarct, Chronic 1 (2%)
Mineralization 1 (2%) 10 (100%) 2 (4%) 10 (100%) 1 (2%) 10 (100%)
Nephropathy, Chronic 44 (88%) 9 (90%) 41 (82%) 10 (100%) 46 (92%) 10 (100%)
Renal Tubule, Epithelium, Hypertrophy 1 (2%)
Urinary Bladder (50) (10) (49) (10) (50) (10)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 16
Natural Death 6
Survivors
Terminal Sacrifice 28
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (50) (10)
Parasite Metazoan 1 (2%)
Liver (50) (10)
Basophilic Focus 36 (72%) 10 (100%)
Clear Cell Focus 1 (2%)
Eosinophilic Focus 4 (8%)
Fatty Change 19 (38%)
Hepatodiaphragmatic Nodule 8 (16%)
Inflammation, Chronic 21 (42%) 4 (40%)
Mixed Cell Focus 34 (68%) 10 (100%)
Bile Duct, Hyperplasia 20 (40%) 3 (30%)
Hepatocyte, Degeneration, Cystic 4 (8%)
Hepatocyte, Vacuolization Cytoplasmic 34 (68%) 8 (80%)
Periportal, Kupffer Cell, Hypertrophy 42 (84%) 10 (100%)
Sinusoid, Dilatation 1 (2%)
Mesentery (4)
Inflammation, Necrotizing 2 (50%)
Mineralization 1 (25%)
Pancreas (49) (10)
Acinus, Atrophy 23 (47%) 3 (30%)
Salivary Glands (50) (10)
Atrophy 1 (2%)
Stomach, Forestomach (49) (10)
Acanthosis 1 (2%)
Diverticulum 1 (2%)
Inflammation, Chronic Active 1 (2%)
Stomach, Glandular (49) (10)
Diverticulum 2 (4%)
Inflammation, Chronic Active 1 (2%)
Tongue (1)
Epithelium, Acanthosis 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10)
Cardiomyopathy, Chronic 39 (78%) 6 (60%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (10)
Degeneration, Fatty 15 (30%) 1 (10%)
Hyperplasia 10 (20%) 1 (10%)
Hypertrophy 1 (2%)
Necrosis, Coagulative 1 (2%)
Adrenal Medulla (50) (10)
Hyperplasia 7 (14%)
Parathyroid Gland (50) (10)
Hyperplasia 1 (2%)
Pituitary Gland (49) (10)
Craniopharyngeal Duct, Cyst 1 (2%)
Pars Distalis, Cyst 22 (45%) 5 (50%)
Pars Distalis, Hyperplasia 22 (45%) 3 (30%)
Thyroid Gland (50) (10)
C-Cell, Hyperplasia 18 (36%) 1 (10%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (10)
Hyperplasia 5 (10%)
Inflammation, Chronic Active 2 (4%) 2 (20%)
Duct, Dilatation 2 (4%)
Ovary (50) (10)
Atrophy 1 (2%)
Cyst 16 (32%) 2 (20%)
Uterus (50) (10)
Dilatation 2 (4%)
Diverticulum 2 (4%)
Hemorrhage 1 (2%)
Hyperplasia, Cystic, Glandular 1 (2%)
Inflammation, Chronic Active 2 (4%)
Inflammation, Suppurative 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Vagina (3)
Estrus 1 (33%)
Exudate 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10)
Femoral, Myelofibrosis 2 (4%)
Lymph Node, Mandibular (50) (10)
Sinus, Ectasia 2 (20%)
Spleen (50) (10)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10)
Hyperplasia, Cystic 45 (90%) 10 (100%)
Skin (50) (10)
Acanthosis 2 (4%)
Inflammation, Chronic Active 2 (4%)
Ulcer, Multiple 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (50) (10)
Inflammation, Chronic Active 1 (2%)
Necrosis, Coagulative 3 (6%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10)
Compression 1 (2%)
Hemorrhage, Acute 2 (4%)
Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 19 (38%) 5 (50%)
Leukocytosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (10%)
Alveolus, Infiltration Cellular, Histiocyte 34 (68%)
Nose (50) (10)
Fungus 1 (10%)
Inflammation, Chronic Active 4 (8%) 1 (10%)
Nasolacrimal Duct, Cyst 1 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 9 (18%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (1)
Cornea, Inflammation, Chronic Active 1 (25%)
Lens, Cataract 3 (75%)
Retina, Atrophy 3 (75%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10)
Cyst 2 (4%)
Mineralization 8 (80%)
Necrosis, Coagulative 1 (2%)
Nephropathy, Chronic 48 (96%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 7
Early Deaths
Moribund Sacrifice 23 14 22 3
Natural Death 9 8 6
Survivors
Terminal Sacrifice 18 28 22
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (10) (50) (10) (50) (10)
Parasite Metazoan 2 (4%) 2 (4%)
Intestine Large, Rectum (50) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 2 (4%)
Parasite Metazoan 5 (10%) 3 (30%) 1 (2%) 1 (10%) 2 (4%) 1 (10%)
Liver (50) (10) (50) (10) (50) (10)
Basophilic Focus 18 (36%) 5 (50%) 22 (44%) 2 (20%) 23 (46%) 9 (90%)
Clear Cell Focus 2 (4%) 1 (2%)
Eosinophilic Focus 3 (6%) 7 (14%) 2 (4%)
Fatty Change 15 (30%) 14 (28%) 13 (26%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 3 (6%) 2 (20%) 4 (8%) 2 (20%)
Inflammation, Chronic 8 (16%) 1 (10%) 2 (4%) 1 (10%) 6 (12%) 1 (10%)
Mixed Cell Focus 6 (12%) 1 (10%) 14 (28%) 1 (10%) 18 (36%) 1 (10%)
Necrosis, Coagulative 2 (4%) 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Bile Duct, Cyst 1 (10%)
Bile Duct, Hyperplasia 45 (90%) 9 (90%) 47 (94%) 9 (90%) 43 (86%) 10 (100%)
Hepatocyte, Degeneration, Cystic 10 (20%) 14 (28%) 9 (18%)
Hepatocyte, Vacuolization Cytoplasmic 13 (26%) 1 (10%) 11 (22%) 10 (100%) 19 (38%) 7 (70%)
Periportal, Kupffer Cell, Hypertrophy 2 (4%) 3 (6%) 2 (4%)
Mesentery (11) (2) (7) (1) (10) (1)
Ectopic Tissue 1 (10%)
Inflammation, Chronic Active 2 (18%) 2 (100%) 1 (100%) 1 (100%)
Inflammation, Necrotizing 6 (55%) 4 (57%) 7 (70%)
Mineralization 2 (18%) 1 (14%) 1 (10%)
Pancreas (50) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 1 (10%)
Acinus, Atrophy 27 (54%) 5 (50%) 25 (50%) 4 (40%) 28 (56%) 3 (30%)
Artery, Inflammation, Chronic Active 1 (2%) 2 (4%)
Artery, Necrosis, Fibrinoid 1 (2%)
Stomach, Forestomach (50) (10) (50) (10) (50) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acanthosis 3 (6%) 1 (2%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Stomach, Glandular (50) (10) (50) (10) (50) (10)
Erosion 1 (2%) 1 (2%)
Inflammation, Chronic Active 4 (8%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Mesenteric Artery, Hemorrhage 1 (100%)
Mesenteric Artery, Inflammation, Chronic
Active 1 (100%)
Heart (50) (10) (50) (10) (50) (10)
Bacterium 1 (2%)
Cardiomyopathy, Chronic 47 (94%) 10 (100%) 45 (90%) 10 (100%) 40 (80%) 10 (100%)
Metaplasia, Cartilagenous 1 (2%)
Mineralization 1 (2%) 1 (10%)
Thrombosis 6 (12%) 4 (8%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (10) (50) (10) (50) (10)
Accessory Adrenal Cortical Nodule 2 (4%)
Degeneration, Fatty 19 (38%) 1 (10%) 15 (30%) 2 (20%) 15 (30%) 1 (10%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 10 (20%) 1 (10%) 9 (18%) 1 (10%) 9 (18%)
Hypertrophy 1 (2%) 1 (2%)
Inflammation, Necrotizing 1 (2%)
Necrosis, Coagulative 2 (4%) 1 (2%)
Adrenal Medulla (50) (10) (50) (10) (50) (10)
Hyperplasia 15 (30%) 1 (10%) 21 (42%) 21 (42%)
Necrosis 1 (2%) 1 (2%)
Islets, Pancreatic (50) (10) (50) (10) (50) (10)
Hyperplasia 1 (2%)
Parathyroid Gland (47) (10) (45) (10) (47) (10)
Hyperplasia 1 (2%)
Pituitary Gland (50) (10) (49) (10) (50) (10)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Craniopharyngeal Duct, Pars Intermedia, Cyst
Multilocular 1 (2%)
Pars Distalis, Cyst 3 (6%) 7 (14%) 4 (8%) 2 (20%)
Pars Distalis, Degeneration, Cystic 1 (2%)
Pars Distalis, Hyperplasia 19 (38%) 3 (30%) 10 (20%) 5 (50%) 14 (28%) 7 (70%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Pigmentation, Hemosiderin 1 (10%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Pars Intermedia, Ectasia 1 (2%)
Thyroid Gland (50) (10) (50) (10) (50) (10)
Cyst 1 (2%)
Inflammation, Chronic Active 2 (4%)
C-Cell, Hyperplasia 9 (18%) 4 (40%) 12 (24%) 2 (20%) 14 (28%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Inflammation, Chronic Active 1 (100%)
Epididymis (50) (10) (50) (10) (50) (10)
Granuloma Sperm 1 (2%) 5 (10%) 4 (8%)
Hypospermia 2 (20%) 1 (10%)
Preputial Gland (50) (10) (49) (10) (49) (10)
Hyperplasia 3 (6%) 6 (12%) 6 (12%)
Inflammation, Chronic Active 48 (96%) 8 (80%) 43 (88%) 9 (90%) 39 (80%) 8 (80%)
Metaplasia, Osseous 1 (2%)
Duct, Dilatation 1 (2%) 3 (6%)
Prostate (49) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 33 (67%) 8 (80%) 32 (64%) 7 (70%) 28 (56%) 10 (100%)
Seminal Vesicle (49) (10) (50) (10) (50) (10)
Atrophy 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Testes (50) (10) (49) (10) (50) (10)
Granuloma Sperm 1 (10%)
Inflammation, Chronic 1 (2%)
Mineralization 35 (70%) 37 (76%) 2 (20%) 44 (88%) 2 (20%)
Spermatocele 1 (2%)
Arteriole, Inflammation, Chronic Active 1 (2%)
Interstitial Cell, Hyperplasia 23 (46%) 10 (100%) 29 (59%) 10 (100%) 28 (56%) 10 (100%)
Seminiferous Tubule, Atrophy 5 (10%) 1 (10%) 1 (2%) 1 (10%) 1 (2%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50) (10) (50) (10)
Femoral, Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (24) (19) (26)
Mediastinal, Edema 1 (4%)
Mediastinal, Hyperplasia, Plasma Cell 1 (4%)
Lymph Node, Mandibular (48) (10) (50) (10) (50) (10)
Cyst 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (10%) 2 (4%)
Necrosis, Coagulative 1 (2%)
Sinus, Ectasia 1 (10%) 1 (10%)
Lymph Node, Mesenteric (50) (10) (50) (10) (49) (10)
Sinus, Ectasia 1 (2%)
Spleen (50) (10) (50) (10) (49) (10)
Depletion Lymphoid 1 (2%)
Fibrosis 4 (8%) 1 (10%) 9 (18%) 1 (10%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Red Pulp, Atrophy 2 (4%) 1 (2%)
Thymus (48) (10) (46) (10) (46) (10)
Ectopic Parathyroid Gland 1 (2%) 1 (2%)
Ectopic Thyroid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (10) (47) (10) (46) (10)
Hyperplasia, Cystic 28 (60%) 9 (90%) 37 (79%) 10 (100%) 34 (74%) 10 (100%)
Skin (50) (10) (50) (10) (50) (10)
Acanthosis 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (10) (50) (10)
Cranium, Fibrous Osteodystrophy 1 (2%)
Femur, Fibrous Osteodystrophy 1 (2%)
Skeletal Muscle (50) (10) (50) (10) (50) (10)
Fibrosis 1 (2%)
Mineralization 1 (2%)
Necrosis, Coagulative 7 (14%) 2 (20%) 7 (14%) 5 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (10) (50) (10)
Compression 4 (8%) 1 (2%) 2 (4%)
Cyst 1 (2%)
Hemorrhage, Acute 2 (4%) 2 (4%)
Hydrocephalus 4 (8%) 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Spinal Cord (2) (2) (3) (1)
Hemorrhage, Acute 1 (50%) 1 (33%)
White Matter, Degeneration 1 (50%) 2 (67%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 10 (20%) 1 (10%) 6 (12%) 1 (10%) 8 (16%) 2 (20%)
Leukocytosis 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (10%)
Alveolar Epithelium, Hyperplasia 4 (8%) 1 (2%) 1 (10%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 10 (20%) 10 (20%) 13 (26%)
Nose (50) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 3 (6%) 3 (6%) 1 (10%) 4 (8%) 1 (10%)
Thrombosis 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 15 (30%) 2 (20%) 13 (26%) 4 (8%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (2)
Inflammation, Chronic Active 1 (100%)
Eye (3) (2) (5)
Anterior Chamber, Hemorrhage, Acute 1 (20%)
Cornea, Inflammation, Chronic Active 1 (33%) 1 (20%)
Lens, Cataract 1 (33%) 1 (50%) 4 (80%)
Retina, Atrophy 1 (33%) 2 (100%) 3 (60%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (10) (50) (10)
Bacterium 1 (2%)
Cyst 1 (2%) 1 (10%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis, Coagulative 2 (4%) 2 (4%)
Nephropathy, Chronic 47 (94%) 10 (100%) 48 (96%) 10 (100%) 47 (94%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Urinary Bladder (49) (10) (50) (10) (50) (10)
Inflammation, Chronic Active 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 23
Natural Death 9
Survivors
Terminal Sacrifice 18
Animals Examined Microscopically 49 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (10)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Rectum (48) (10)
Parasite Metazoan 1 (2%) 1 (10%)
Intestine Large, Cecum (49) (10)
Inflammation, Chronic Active 1 (2%)
Liver (49) (10)
Basophilic Focus 22 (45%) 10 (100%)
Clear Cell Focus 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change 15 (31%)
Hepatodiaphragmatic Nodule 4 (8%)
Inflammation, Chronic 3 (6%)
Mixed Cell Focus 15 (31%) 5 (50%)
Necrosis, Coagulative 2 (4%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 46 (94%) 9 (90%)
Hepatocyte, Degeneration, Cystic 11 (22%)
Hepatocyte, Vacuolization Cytoplasmic 18 (37%) 10 (100%)
Periportal, Kupffer Cell, Hypertrophy 31 (63%) 10 (100%)
Mesentery (9)
Hemorrhage, Acute 1 (11%)
Inflammation, Chronic Active 1 (11%)
Inflammation, Necrotizing 4 (44%)
Mineralization 1 (11%)
Pancreas (49) (10)
Acinus, Atrophy 30 (61%) 3 (30%)
Stomach, Forestomach (49) (10)
Acanthosis 1 (2%)
Stomach, Glandular (49) (10)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (10)
Cardiomyopathy, Chronic 39 (80%) 10 (100%)
Metaplasia, Cartilagenous 1 (2%)
Mineralization 1 (2%)
Thrombosis 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (10)
Accessory Adrenal Cortical Nodule 3 (6%)
Degeneration, Fatty 16 (33%)
Hyperplasia 13 (27%)
Necrosis, Coagulative 4 (8%)
Adrenal Medulla (49) (10)
Hyperplasia 18 (37%)
Islets, Pancreatic (49) (10)
Hyperplasia 1 (2%)
Parathyroid Gland (46) (10)
Hyperplasia 2 (4%)
Pituitary Gland (49) (10)
Pars Distalis, Cyst 3 (6%)
Pars Distalis, Hyperplasia 20 (41%) 2 (20%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (49) (10)
Cyst 1 (10%)
Inflammation, Chronic Active 1 (2%)
C-Cell, Hyperplasia 8 (16%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (10)
Granuloma Sperm 9 (18%)
Preputial Gland (49) (10)
Hyperplasia 5 (10%)
Inflammation, Chronic Active 44 (90%) 6 (60%)
Duct, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Prostate (48) (10)
Inflammation, Chronic Active 40 (83%) 10 (100%)
Testes (49) (10)
Cyst 1 (2%)
Mineralization 29 (59%) 1 (10%)
Interstitial Cell, Hyperplasia 34 (69%) 10 (100%)
Seminiferous Tubule, Atrophy 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (49) (10)
Cyst 2 (4%)
Spleen (49) (10)
Ectopic Tissue 2 (4%)
Fibrosis 4 (8%)
Hematopoietic Cell Proliferation 1 (2%)
Necrosis, Coagulative 2 (4%)
Red Pulp, Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (10)
Hyperplasia, Cystic 33 (67%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (10)
Cranium, Fibrous Osteodystrophy 1 (2%)
Femur, Fibrous Osteodystrophy 1 (2%)
Skeletal Muscle (49) (10)
Necrosis, Coagulative 7 (14%) 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (10)
Hemorrhage, Acute 2 (4%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 19:42:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (10)
Hemorrhage, Acute 3 (6%)
Inflammation, Chronic Active 7 (14%) 2 (20%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%)
Alveolus, Infiltration Cellular, Histiocyte 9 (18%)
Nose (49) (10)
Fungus 1 (2%) 1 (10%)
Inflammation, Chronic Active 7 (14%) 1 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 10 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (10)
Cyst 1 (2%)
Necrosis, Coagulative 2 (4%)
Nephropathy, Chronic 47 (96%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 21:02:21
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-69-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 21:02:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
NEURO HCU NEURO HCU NEURO HCU
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 40 15 40 15 40 15
Scheduled Sacrifice 40 15 40 15 40 12
Early Deaths
Natural Death 2
Moribund Sacrifice 1
Survivors
Animals Examined Microscopically 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 21:02:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
NEURO HCU NEURO HCU NEURO HCU
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (20) (20) (20)
Necrosis, Coagulative 9 (45%) 14 (70%) 17 (85%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/09/95
Route: DOSED FEED Time: 21:02:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
NEURO HCU
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 40 15
Scheduled Sacrifice 40 14
Early Deaths
Moribund Sacrifice 1
Survivors
Animals Examined Microscopically 20
Skeletal Muscle (20)
Necrosis, Coagulative 9 (45%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------