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TDMS Study 05165-01 Pathology Tables

NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95
Route: DOSED FEED                                                                                                 Time: 16:15:07




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-69-5

       Lock Date:  12/26/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           10           50           10           50           10           

  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11                        14                        16                        
    Natural Death                                      5                         5                         2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                34                        30                        32                        
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           10           50           10           50           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (10)         (50)         (10)         (50)         (10)         
   Intestine Small, Duodenum                          (50)         (10)         (50)         (10)         (50)         (10)         
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
   Mesentery                                          (9)          (1)          (7)          (2)          (8)                       
      Schwannoma Malignant                                                       1 (14%)                                            
   Pancreas                                           (50)         (10)         (50)         (10)         (50)         (10)         
   Pharynx                                            (1)                                                 (2)                       
      Palate, Squamous Cell Papilloma                  1 (100%)                                            2 (100%)                 
   Salivary Glands                                    (49)         (10)         (49)         (10)         (50)         (10)         
   Stomach, Glandular                                 (50)         (10)         (50)         (10)         (50)         (10)         
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Tooth                                              (2)                                                 (1)                       
      Gingiva, Squamous Cell Carcinoma                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Schwannoma Malignant, Moderately Well                                                                                         
          Differentiated                                                                                   1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (10)         (50)         (10)         (50)         (10)         
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (10)         (50)         (10)         (49)         (10)         
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                    3 (6%)                   
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             

                                                             Page   2                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (50)         (10)         (50)         (10)         (50)         (10)         
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (49)         (10)         (50)         (10)         (50)         (10)         
      Pars Distalis, Adenoma                          27 (55%)      3 (30%)     15 (30%)      1 (10%)     17 (34%)                  
   Thyroid Gland                                      (49)         (10)         (49)         (10)         (50)         (10)         
      Bilateral, C-Cell, Adenoma                                                                           1 (2%)                   
      C-Cell, Adenoma                                  3 (6%)                    2 (4%)                    7 (14%)                  
      C-Cell, Carcinoma                                                          2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (10)         (48)         (10)         (50)         (10)         
      Adenoma                                          4 (8%)                    1 (2%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Ovary                                              (50)         (10)         (50)         (10)         (50)         (10)         
   Uterus                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Polyp Stromal                                    2 (4%)                    5 (10%)                   9 (18%)      1 (10%)     
      Sarcoma Stromal                                                            1 (2%)                                             
   Vagina                                                                                                 (2)                       
      Fibrosarcoma                                                                                         1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (50)         (10)         (50)         (10)         
   Lymph Node                                         (14)                      (10)                      (10)                      
   Lymph Node, Mandibular                             (49)         (10)         (49)         (10)         (50)         (10)         
   Lymph Node, Mesenteric                             (50)         (10)         (50)         (10)         (50)         (10)         
   Spleen                                             (50)         (10)         (50)         (10)         (50)         (10)         
   Thymus                                             (47)         (10)         (49)         (10)         (47)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)         (50)         (10)         (50)         (10)         
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                          2 (4%)                    1 (2%)                                             
      Fibroadenoma                                    18 (36%)                  14 (28%)      1 (10%)      9 (18%)                  
      Fibroadenoma, Multiple                          11 (22%)                  10 (20%)                   2 (4%)                   
   Skin                                               (50)         (10)         (50)         (10)         (50)         (10)         
      Squamous Cell Papilloma                          1 (2%)                                                                       

                                                             Page   3                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibroma                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (10)         (50)         (10)         (50)         (10)         
      Cervical, Vertebra, Hemangiosarcoma                                                                  1 (2%)                   
      Femur, Osteosarcoma                              1 (2%)                                                                       
   Skeletal Muscle                                    (50)         (10)         (50)         (10)         (50)         (10)         
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)         (10)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (49)         (10)         (49)         (10)         
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                              1 (2%)                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Fibrosarcoma                                                                                         1 (2%)                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Nose                                               (50)         (10)         (50)         (10)         (50)         (10)         
      Squamous Cell Carcinoma, Metastatic, Tooth       1 (2%)                                                                       
   Trachea                                            (50)         (10)         (50)         (10)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Fibrosarcoma                                                               1 (100%)                                           
   Harderian Gland                                    (49)         (10)         (50)         (10)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (50)         (10)         (50)         (10)         
   Urinary Bladder                                    (50)         (10)         (49)         (10)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(10)         
      Leukemia Mononuclear                            18 (36%)                  18 (36%)                  22 (44%)                  
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(10)         
____________________________________________________________________________________________________________________________________

                                                             Page   5                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47           3          45           2          43           1               
     Total Primary Neoplasms                           98           3          76           2          78           1               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42           3          35           2          36           1               
     Total Benign Neoplasms                            75           3          52           2          52           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22                      23                      24                           
     Total Malignant Neoplasms                         23                      24                      26                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       1                                                   
     Total Metastatic Neoplasm                          3                       1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           10                                                               

  Scheduled Sacrifice                                              10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16                                                                            
    Natural Death                                      6                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                                                            

  Animals Examined Microscopically                    50           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (10)                                                             
   Intestine Large, Cecum                             (49)         (9)                                                              
   Intestine Small, Duodenum                          (49)         (10)                                                             
   Intestine Small, Jejunum                           (49)         (10)                                                             
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (10)                                                             
   Liver                                              (50)         (10)                                                             
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (4)                                                                           
   Pancreas                                           (49)         (10)                                                             
   Stomach, Forestomach                               (49)         (10)                                                             
   Stomach, Glandular                                 (49)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (10)                                                             
   Adrenal Medulla                                    (50)         (10)                                                             
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (10)                                                             
      Pars Distalis, Adenoma                          16 (33%)      1 (10%)                                                         
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)                                                             
      C-Cell, Adenoma                                  8 (16%)                                                                      

                                                             Page   7                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Carcinoma                                2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (4%)                                                                       
   Ovary                                              (50)         (10)                                                             
   Uterus                                             (50)         (10)                                                             
      Polyp Stromal                                    9 (18%)                                                                      
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)                                                             
   Lymph Node                                         (10)                                                                          
   Lymph Node, Mandibular                             (50)         (10)                                                             
   Lymph Node, Mesenteric                             (50)         (10)                                                             
   Spleen                                             (50)         (10)                                                             
   Thymus                                             (48)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)                                                             
      Fibroadenoma                                    14 (28%)                                                                      
      Fibroadenoma, Multiple                           2 (4%)                                                                       
   Skin                                               (50)         (10)                                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)                                                             
   Spinal Cord                                        (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)                                                             
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                                                             
   Urinary Bladder                                    (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(10)                                                             
      Leukemia Mononuclear                            20 (40%)                                                                      
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   9                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47           1                                                               
     Total Primary Neoplasms                           83           1                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38           1                                                               
     Total Benign Neoplasms                            55           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25                                                                           
     Total Malignant Neoplasms                         28                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  10                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           10           50           10           50           10           

  Scheduled Sacrifice                                              10                        10                         7           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23                        14                        22            3           
    Natural Death                                      9                         8                         6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                18                        28                        22                        

  Animals Examined Microscopically                    50           10           50           10           50           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (10)         (50)         (10)         (50)         (10)         
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Rectum                            (50)         (10)         (50)         (10)         (50)         (10)         
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (10)         (50)         (10)         (50)         (10)         
      Adenocarcinoma                                                                                       1 (2%)                   
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)                    2 (4%)                    2 (4%)                   
      Hepatocellular Adenoma, Multiple                                                                     1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Mesentery                                          (11)         (2)          (7)          (1)          (10)         (1)          
      Histiocytic Sarcoma                                                                                  1 (10%)                  
      Liposarcoma                                                                1 (14%)                                            
   Pancreas                                           (50)         (10)         (50)         (10)         (50)         (10)         
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Pharynx                                                                      (1)          (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (49)         (10)         (50)         (10)         (50)         (10)         
   Stomach, Forestomach                               (50)         (10)         (50)         (10)         (50)         (10)         
      Leiomyosarcoma                                   1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (10)         (50)         (10)         (50)         (10)         
   Tongue                                             (1)                       (2)                       (1)                       
      Squamous Cell Papilloma                          1 (100%)                  1 (50%)                   1 (100%)                 
   Tooth                                              (1)                                                                           
      Peridontal Tissue, Fibrosarcoma                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  11                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)         (10)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (10)         (50)         (10)         (50)         (10)         
   Adrenal Medulla                                    (50)         (10)         (50)         (10)         (50)         (10)         
      Pheochromocytoma Malignant                                                                           1 (2%)                   
      Pheochromocytoma Benign                         11 (22%)      1 (10%)     12 (24%)      1 (10%)      7 (14%)                  
      Bilateral, Pheochromocytoma Benign               3 (6%)                    2 (4%)                    3 (6%)                   
   Islets, Pancreatic                                 (50)         (10)         (50)         (10)         (50)         (10)         
      Adenoma                                          2 (4%)                                 1 (10%)                               
      Carcinoma                                                                  1 (2%)                    1 (2%)                   
   Parathyroid Gland                                  (47)         (10)         (45)         (10)         (47)         (10)         
      Adenoma                                          2 (4%)                                                                       
   Pituitary Gland                                    (50)         (10)         (49)         (10)         (50)         (10)         
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Pars Distalis, Adenoma                          14 (28%)      1 (10%)     10 (20%)      2 (20%)     10 (20%)      1 (10%)     
      Pars Distalis, Adenoma, Multiple                                                                     2 (4%)                   
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)         (50)         (10)         (50)         (10)         
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  4 (8%)                    3 (6%)                    8 (16%)                  
      Follicular Cell, Adenoma                                                   2 (4%)       1 (10%)      1 (2%)                   
      Follicular Cell, Carcinoma                       1 (2%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (50)         (10)         (50)         (10)         
   Preputial Gland                                    (50)         (10)         (49)         (10)         (49)         (10)         
      Adenoma                                          1 (2%)                    4 (8%)                    2 (4%)                   
      Carcinoma                                        2 (4%)                    2 (4%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Bilateral, Adenoma                                                         1 (2%)                    1 (2%)                   
   Prostate                                           (49)         (10)         (50)         (10)         (50)         (10)         
   Seminal Vesicle                                    (49)         (10)         (50)         (10)         (50)         (10)         
   Testes                                             (50)         (10)         (49)         (10)         (50)         (10)         
      Bilateral, Interstitial Cell, Adenoma           36 (72%)      5 (50%)     38 (78%)      5 (50%)     42 (84%)      2 (20%)     
      Interstitial Cell, Adenoma                      10 (20%)      1 (10%)      6 (12%)      3 (30%)      5 (10%)      4 (40%)     
____________________________________________________________________________________________________________________________________

                                                             Page  12                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (50)         (10)         (50)         (10)         
      Femoral, Histiocytic Sarcoma                                                                         1 (2%)                   
      Maxilla, Histiocytic Sarcoma                                                                         1 (2%)                   
   Lymph Node                                         (24)                      (19)                      (26)                      
      Mediastinal, Histiocytic Sarcoma                                                                     1 (4%)                   
      Pancreatic, Histiocytic Sarcoma                                                                      1 (4%)                   
      Renal, Leiomyosarcoma, Metastatic, Stomach,                                                                                   
           Forestomach                                 1 (4%)                                                                       
   Lymph Node, Mandibular                             (48)         (10)         (50)         (10)         (50)         (10)         
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Lymph Node, Mesenteric                             (50)         (10)         (50)         (10)         (49)         (10)         
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Spleen                                             (50)         (10)         (50)         (10)         (49)         (10)         
      Fibrosarcoma                                                                                         1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Thymus                                             (48)         (10)         (46)         (10)         (46)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (10)         (47)         (10)         (46)         (10)         
      Adenoacanthoma                                   1 (2%)                                                                       
      Fibroadenoma                                     3 (6%)                    4 (9%)                                             
   Skin                                               (50)         (10)         (50)         (10)         (50)         (10)         
      Basosquamous Tumor Benign                        1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Keratoacanthoma                                  1 (2%)                    1 (2%)                    1 (2%)                   
      Squamous Cell Papilloma                          2 (4%)                    1 (2%)                                             
      Sebaceous Gland, Adenocarcinoma                                                                      1 (2%)                   
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     5 (10%)                   1 (2%)                    4 (8%)                   
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Neurofibroma                                          1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)         (10)         (50)         (10)         
      Cranium, Chondrosarcoma                                                    1 (2%)                                             
      Cranium, Hemangiosarcoma                                                                                          1 (10%)     
      Cranium, Osteosarcoma                                                                                1 (2%)                   
      Femur, Histiocytic Sarcoma                                                                           1 (2%)                   
      Femur, Osteosarcoma                                                                                  1 (2%)                   
      Maxilla, Histiocytic Sarcoma                                                                         1 (2%)                   
   Skeletal Muscle                                    (50)         (10)         (50)         (10)         (50)         (10)         

                                                             Page  13                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Osteosarcoma, Metastatic, Bone                                                                       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Astrocytoma Malignant                                                      2 (4%)                                             
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Oligodendroglioma Malignant                      1 (2%)                                                                       
   Spinal Cord                                        (2)                       (2)                       (3)          (1)          
      Astrocytoma Malignant                            1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (10)         (50)         (10)         (50)         (10)         
      Adenocarcinoma, Metastatic, Zymbal's Gland       1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                                               2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Osteosarcoma, Metastatic, Bone                                                                       1 (2%)                   
      Mediastinum, Schwannoma Malignant                1 (2%)                                                                       
   Nose                                               (50)         (10)         (50)         (10)         (50)         (10)         
      Chondrosarcoma, Metastatic, Bone                                           1 (2%)                                             
      Squamous Cell Carcinoma                                                                              2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (1)                       (2)                       
      Fibrosarcoma                                                               1 (100%)                                           
   Eye                                                (3)                       (2)                       (5)                       
      Lids, Left, Fibroma                                                                                  1 (20%)                  
   Harderian Gland                                    (49)         (10)         (49)         (9)          (50)         (10)         
   Zymbal's Gland                                     (1)                       (1)                                    (1)          
      Adenocarcinoma                                   1 (100%)                  1 (100%)                               1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (50)         (10)         (50)         (10)         
   Urinary Bladder                                    (49)         (10)         (50)         (10)         (50)         (10)         

                                                             Page  14                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(10)         
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Leukemia Mononuclear                            30 (60%)                  36 (72%)                  34 (68%)                  
      Mesothelioma Malignant                           2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  15                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                                 65 PATH                   65 PATH                   65 PATH        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49           7          49           9          50           9               
     Total Primary Neoplasms                          143           8         144          14         137           9               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49           7          47           9          50           7               
     Total Benign Neoplasms                            99           8          93          14          92           7               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37                      41                      39           2               
     Total Malignant Neoplasms                         44                      51                      45           2               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       1                       1                           
     Total Metastatic Neoplasm                          3                       1                       2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  16                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           10                                                               

  Scheduled Sacrifice                                              10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23                                                                            
    Natural Death                                      9                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                18                                                                            

  Animals Examined Microscopically                    49           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (10)                                                             
   Intestine Large, Cecum                             (49)         (10)                                                             
   Intestine Small, Ileum                             (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Liver                                              (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           4 (8%)                                                                       
   Mesentery                                          (9)                                                                           
   Pancreas                                           (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Salivary Glands                                    (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (10)                                                             
   Stomach, Glandular                                 (49)         (10)                                                             
   Tongue                                             (1)                                                                           
      Carcinoma, Metastatic, Kidney                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       

                                                             Page  17                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          9 (18%)      1 (10%)                                                         
      Bilateral, Pheochromocytoma Malignant            1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (10)                                                             
      Pars Distalis, Adenoma                           9 (18%)                                                                      
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
   Thyroid Gland                                      (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      C-Cell, Adenoma                                  2 (4%)       1 (10%)                                                         
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (10)                                                             
   Preputial Gland                                    (49)         (10)                                                             
      Adenoma                                          4 (8%)                                                                       
   Prostate                                           (48)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Seminal Vesicle                                    (48)         (10)                                                             
   Testes                                             (49)         (10)                                                             
      Bilateral, Interstitial Cell, Adenoma           31 (63%)      3 (30%)                                                         
      Interstitial Cell, Adenoma                      13 (27%)      3 (30%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)                                                             
   Lymph Node                                         (30)                                                                          
      Mediastinal, Carcinoma, Metastatic, Kidney       1 (3%)                                                                       
   Lymph Node, Mandibular                             (49)         (10)                                                             
   Lymph Node, Mesenteric                             (48)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Spleen                                             (49)         (10)                                                             
   Thymus                                             (46)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  18                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (10)                                                             
      Fibroadenoma                                     2 (4%)                                                                       
   Skin                                               (48)         (10)                                                             
      Keratoacanthoma                                  2 (4%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Neurofibroma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (49)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (10)                                                             
      Astrocytoma Malignant                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
   Nose                                               (49)         (10)                                                             
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (10)                                                             
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (48)         (10)                                                             

                                                             Page  19                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(49)        *(10)                                                             
      Leukemia Mononuclear                            33 (67%)                                                                      
      Mesothelioma Benign                                           1 (10%)                                                         
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  20                                                               
NTP Experiment-Test: 05165-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:15:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                                 65 PATH                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49           7                                                               
     Total Primary Neoplasms                          123           9                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46           7                                                               
     Total Benign Neoplasms                            83           9                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37                                                                           
     Total Malignant Neoplasms                         40                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                         15                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  21                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP Experiment-Test: 05165-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95
Route: DOSED FEED                                                                                                 Time: 16:32:54




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-69-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05165-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:32:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                    NEURO        HCU          NEURO        HCU          NEURO        HCU            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          40           15           40           15           40           15           

  Scheduled Sacrifice                                 40           15           40           15           40           12           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       2           
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         

  Animals Examined Microscopically                    20                        20                        20                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

                                                             Page   2                                                               
NTP Experiment-Test: 05165-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:32:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        500 PPM      500 PPM      1000 PPM     1000 PPM        
                                                    NEURO        HCU          NEURO        HCU          NEURO        HCU            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

                                                             Page   3                                                               
NTP Experiment-Test: 05165-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:32:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                    NEURO        HCU                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          40           15                                                               

  Scheduled Sacrifice                                 40           14                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         

  Animals Examined Microscopically                    20                                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

                                                             Page   4                                                               
NTP Experiment-Test: 05165-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                             Date: 11/10/95  
Route: DOSED FEED                                                                                                 Time: 16:32:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2500 PPM     2500 PPM                                                            
                                                    NEURO        HCU                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

                                                             Page   5                                                               
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