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TDMS Study 05165-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95       
EXPERIMENT: 05165 TEST: 01                                                                                     TIME: 19:59:27       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B       
PATHOLOGIST: J. TOFT                                                                                           CAS: 96-69-5         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95       
EXPERIMENT: 05165 TEST: 01                                                                                     TIME: 19:59:27       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B       
PATHOLOGIST: J. TOFT                                                                                           CAS: 96-69-5         




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                              4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)                           DATE: 11/09/95       
EXPERIMENT: 05165 TEST: 01                                                                                     TIME: 19:59:27       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-65156                              ROUTE: DOSED FEED                                              NTP C#: 61610B       
PATHOLOGIST: J. TOFT                                                                                           CAS: 96-69-5         




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                IN THE ANALYSIS OF THE STUDY OF 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Skin                          Fibroma
              Testes                        Adenoma
              All Organs                    Benign Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Clitoral/Preputial Gland      Carcinoma or Adenoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                            Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              Uterus                        Polyp Stromal
                                            Sarcoma Stromal or Polyp Stromal

              ====================================================================================================
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   1
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  15/60 (25%)  10/60 (17%)  10/59 (17%) |  1/60 (2%)    2/60 (3%)    3/59 (5%)    1/60 (2%)  |
|ADJUSTED (b)           |  59.5%        45.5%        40.9%        37.4%      |   2.9%         6.2%         9.4%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   0/7 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  9/18 (50%)  11/28 (39%)   8/22 (36%)   4/18 (22%) |  1/34 (3%)    1/31 (3%)    3/32 (9%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   449 (I)      449 (I)      697          449 (I)   |   729 (T)      712          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.210N     P=0.156N     P=0.067N     P=0.180N   |  P=0.614N     P=0.459      P=0.283      P=0.718    |
|INCIDENTAL TUMOR       |  P=0.138N     P=0.331N     P=0.077N     P=0.141N   |  P=0.611N     P=0.469      P=0.283      P=0.718    |
|LOGISTIC REGRESSION    |  P=0.149N     P=0.377N     P=0.075N     P=0.174N   |  P=0.619N     P=0.459      P=0.283      P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.136N                                          |  P=0.541N                                          |
|FISHER EXACT           |               P=0.583N     P=0.184N     P=0.197N   |               P=0.500      P=0.303      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  15/60 (25%)  10/60 (17%)  11/59 (19%) |  1/60 (2%)    2/60 (3%)    3/59 (5%)    2/60 (3%)  |
|ADJUSTED (b)           |  59.5%        45.5%        40.9%        41.9%      |   2.9%         6.2%         9.4%         5.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   1/10 (10%)   0/7 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  9/18 (50%)  11/28 (39%)   8/22 (36%)   5/18 (28%) |  1/34 (3%)    1/31 (3%)    3/32 (9%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   449 (I)      449 (I)      697          449 (I)   |   729 (T)      712          729 (T)      541       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.302N     P=0.156N     P=0.067N     P=0.245N   |  P=0.394      P=0.459      P=0.283      P=0.455    |
|INCIDENTAL TUMOR       |  P=0.212N     P=0.331N     P=0.077N     P=0.201N   |  P=0.426      P=0.469      P=0.283      P=0.488    |
|LOGISTIC REGRESSION    |  P=0.226N     P=0.377N     P=0.075N     P=0.243N   |  P=0.421      P=0.459      P=0.283      P=0.492    |
|COCHRAN-ARMITAGE       |  P=0.202N                                          |  P=0.462                                           |
|FISHER EXACT           |               P=0.583N     P=0.184N     P=0.269N   |               P=0.500      P=0.303      P=0.500    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   2
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/59 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.7%         0.0%      |   2.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          466          ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.713        (e)        P=0.273        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.710N       (e)        P=0.292        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.708        (e)        P=0.220        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.713                                           |  P=0.394N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    2/59 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         6.3%         0.0%         7.6%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/28 (4%)    0/22 (0%)    1/18 (6%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          669          ---          533       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.218      P=0.332        (e)        P=0.245    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.227      P=0.298        (e)        P=0.220    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.238      P=0.279        (e)        P=0.235    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.245                                           |    (e)                                             |
|FISHER EXACT           |               P=0.248        (e)        P=0.244    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   3
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    0/60 (0%)    2/59 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.6%         6.3%         0.0%         7.6%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    1/28 (4%)    0/22 (0%)    1/18 (6%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      669          ---          533       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.411      P=0.643      P=0.460N     P=0.505    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.421      P=0.611      P=0.460N     P=0.479    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.435      P=0.585      P=0.460N     P=0.499    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.446                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.494    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    5/59 (8%)    3/59 (5%)    4/59 (7%)  |  4/59 (7%)    1/58 (2%)    0/60 (0%)    1/59 (2%)  |
|ADJUSTED (b)           |   5.6%        14.9%        10.3%        10.7%      |  12.1%         3.3%         0.0%         2.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    1/22 (5%)    0/18 (0%)  |  4/33 (12%)   1/30 (3%)    0/32 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      625          627          533       |   729 (T)      729 (T)      ---          663       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.246      P=0.213      P=0.391      P=0.199    |  P=0.196N     P=0.207N     P=0.066N     P=0.245N   |
|INCIDENTAL TUMOR       |  P=0.330      P=0.104      P=0.324      P=0.168    |  P=0.197N     P=0.207N     P=0.066N     P=0.244N   |
|LOGISTIC REGRESSION    |  P=0.282      P=0.146      P=0.347      P=0.175    |  P=0.189N     P=0.207N     P=0.066N     P=0.228N   |
|COCHRAN-ARMITAGE       |  P=0.291                                           |  P=0.158N                                          |
|FISHER EXACT           |               P=0.100      P=0.303      P=0.177    |               P=0.187N     P=0.057N     P=0.182N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   4
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/59 (3%)    0/59 (0%)    0/59 (0%)  |  1/59 (2%)    1/58 (2%)    0/60 (0%)    2/59 (3%)  |
|ADJUSTED (b)           |   9.2%         7.1%         0.0%         0.0%      |   2.3%         2.4%         0.0%         4.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  0/33 (0%)    0/30 (0%)    0/32 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   663          729 (T)      ---          ---       |   673          652          ---          597       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.119N     P=0.536N     P=0.193N     P=0.236N   |  P=0.303      P=0.739      P=0.519N     P=0.448    |
|INCIDENTAL TUMOR       |  P=0.110N     P=0.571N     P=0.193N     P=0.213N   |  P=0.496      P=0.746      P=0.557N     P=0.660N   |
|LOGISTIC REGRESSION    |  P=0.115N     P=0.604N     P=0.211N     P=0.238N   |  P=0.350      P=0.757      P=0.501N     P=0.513    |
|COCHRAN-ARMITAGE       |  P=0.114N                                          |  P=0.345                                           |
|FISHER EXACT           |               P=0.684      P=0.252N     P=0.252N   |               P=0.748      P=0.496N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    7/59 (12%)   3/59 (5%)    4/59 (7%)  |  5/59 (8%)    2/58 (3%)    0/60 (0%)    3/59 (5%)  |
|ADJUSTED (b)           |  14.5%        21.5%        10.3%        10.7%      |  14.1%         5.6%         0.0%         7.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   4/28 (14%)   1/22 (5%)    0/18 (0%)  |  4/33 (12%)   1/30 (3%)    0/32 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   663          625          627          533       |   673          652          ---          597       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.567      P=0.361      P=0.554N     P=0.520    |  P=0.475N     P=0.259N     P=0.038N*    P=0.460N   |
|INCIDENTAL TUMOR       |  P=0.505N     P=0.220      P=0.612N     P=0.499    |  P=0.348N     P=0.257N     P=0.041N*    P=0.217N   |
|LOGISTIC REGRESSION    |  P=0.551N     P=0.249      P=0.609N     P=0.495    |  P=0.419N     P=0.248N     P=0.037N*    P=0.387N   |
|COCHRAN-ARMITAGE       |  P=0.534N                                          |  P=0.395N                                          |
|FISHER EXACT           |               P=0.154      P=0.652      P=0.491    |               P=0.226N     P=0.027N*    P=0.358N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   5
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    0/60 (0%)    0/59 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |   6.9%         1.7%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   619          449 (I)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.145N     P=0.448N     P=0.193N     P=0.246N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.135N     P=0.623N     P=0.250N     P=0.229N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.142N     P=0.520N     P=0.227N     P=0.239N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.140N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.248N     P=0.252N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    1/60 (2%)    0/59 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |   6.9%         4.9%         4.5%         0.0%      |   2.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    1/22 (5%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   619          449 (I)      729 (T)      ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.153N     P=0.615N     P=0.427N     P=0.246N   |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.129N     P=0.610      P=0.491N     P=0.229N   |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.141N     P=0.690      P=0.466N     P=0.239N   |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.141N                                          |  P=0.397N                                          |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.252N   |               P=0.500N     P=0.500N     P=0.504N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   6
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    3/60 (5%)    4/59 (7%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.6%         7.1%        13.6%        17.0%      |   0.0%         0.0%         0.0%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    3/22 (14%)   2/18 (11%) |  0/34 (0%)    0/31 (0%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      625       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.079      P=0.653      P=0.377      P=0.182    |  P=0.188        (e)          (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.095      P=0.653      P=0.377      P=0.186    |  P=0.188        (e)          (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.090      P=0.653      P=0.377      P=0.176    |  P=0.188        (e)          (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.126                                           |  P=0.211                                           |
|FISHER EXACT           |               P=0.500      P=0.309      P=0.177    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    3/60 (5%)    5/59 (8%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.6%        10.7%        13.6%        21.0%      |   0.0%         0.0%         0.0%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    3/28 (11%)   3/22 (14%)   2/18 (11%) |  0/34 (0%)    0/31 (0%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      625       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.047 *    P=0.472      P=0.377      P=0.107    |  P=0.188        (e)          (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.063      P=0.472      P=0.377      P=0.118    |  P=0.188        (e)          (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.055      P=0.472      P=0.377      P=0.100    |  P=0.188        (e)          (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.085                                           |  P=0.211                                           |
|FISHER EXACT           |               P=0.309      P=0.309      P=0.100    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   7
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    3/60 (5%)    5/59 (8%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.6%        10.7%        13.6%        21.0%      |   0.0%         0.0%         0.0%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    3/28 (11%)   3/22 (14%)   2/18 (11%) |  0/34 (0%)    0/31 (0%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      625       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.047 *    P=0.472      P=0.377      P=0.107    |  P=0.188        (e)          (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.063      P=0.472      P=0.377      P=0.118    |  P=0.188        (e)          (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.055      P=0.472      P=0.377      P=0.100    |  P=0.188        (e)          (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.085                                           |  P=0.211                                           |
|FISHER EXACT           |               P=0.309      P=0.309      P=0.100    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    2/60 (3%)    0/60 (0%)    0/59 (0%)  |  1/60 (2%)    0/59 (0%)    1/59 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         7.1%         0.0%         0.0%      |   2.9%         0.0%         3.2%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    1/31 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      ---          ---       |   729 (T)      ---          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.457N     P=0.339        (e)          (e)      |  P=0.517      P=0.518N     P=0.741      P=0.718    |
|INCIDENTAL TUMOR       |  P=0.457N     P=0.339        (e)          (e)      |  P=0.517      P=0.518N     P=0.741      P=0.718    |
|LOGISTIC REGRESSION    |  P=0.457N     P=0.339        (e)          (e)      |  P=0.517      P=0.518N     P=0.741      P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.426N                                          |  P=0.563                                           |
|FISHER EXACT           |               P=0.252        (e)          (e)      |               P=0.504N     P=0.748      P=0.752N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   8
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/59 (2%)    3/60 (5%)    0/60 (0%)    0/59 (0%)  |  1/60 (2%)    0/59 (0%)    1/59 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.6%        10.7%         0.0%         0.0%      |   2.9%         0.0%         3.2%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    3/28 (11%)   0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    1/31 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      ---          ---       |   729 (T)      ---          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.188N     P=0.472      P=0.460N     P=0.500N   |  P=0.517      P=0.518N     P=0.741      P=0.718    |
|INCIDENTAL TUMOR       |  P=0.188N     P=0.472      P=0.460N     P=0.500N   |  P=0.517      P=0.518N     P=0.741      P=0.718    |
|LOGISTIC REGRESSION    |  P=0.188N     P=0.472      P=0.460N     P=0.500N   |  P=0.517      P=0.518N     P=0.741      P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.173N                                          |  P=0.563                                           |
|FISHER EXACT           |               P=0.316      P=0.496N     P=0.500N   |               P=0.504N     P=0.748      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/59 (0%)  |  2/60 (3%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.6%         3.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   725          712          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.167N     P=0.547N     P=0.263N     P=0.293N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.163N     P=0.531N     P=0.278N     P=0.282N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.158N     P=0.538N     P=0.259N     P=0.289N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.139N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE   9
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/59 (0%)  |  3/60 (5%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.4%         3.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  2/34 (6%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   725          712          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.088N     P=0.353N     P=0.139N     P=0.165N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.086N     P=0.338N     P=0.148N     P=0.159N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.083N     P=0.348N     P=0.138N     P=0.164N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.069N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.309N     P=0.122N     P=0.122N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    0/60 (0%)    2/59 (3%)  | 29/60 (48%)  25/60 (42%)  11/60 (18%)  16/60 (27%) |
|ADJUSTED (b)           |  11.0%        14.3%         0.0%         7.7%      |  72.2%        59.5%        28.6%        44.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    4/28 (14%)   0/22 (0%)    1/18 (6%)  | 23/34 (68%)  15/31 (48%)   6/32 (19%)   9/28 (32%) |
|FIRST INCIDENCE (DAYS) |   625          729 (T)      ---          555       |   673          372          626          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372N     P=0.615N     P=0.097N     P=0.501N   |  P=0.042N*    P=0.465N     P=0.001N**   P=0.076N   |
|INCIDENTAL TUMOR       |  P=0.348N     P=0.496      P=0.160N     P=0.542N   |  P=0.009N**   P=0.294N     P<0.001N**   P=0.014N*  |
|LOGISTIC REGRESSION    |  P=0.343N     P=0.605      P=0.110N     P=0.502N   |  P=0.013N*    P=0.367N     P<0.001N**   P=0.028N*  |
|COCHRAN-ARMITAGE       |  P=0.332N                                          |  P=0.007N**                                        |
|FISHER EXACT           |               P=0.500      P=0.122N     P=0.508N   |               P=0.291N     P<0.001N**   P=0.012N*  |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  10
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    0/60 (0%)    2/59 (3%)  | 31/60 (52%)  25/60 (42%)  11/60 (18%)  16/60 (27%) |
|ADJUSTED (b)           |  11.0%        14.3%         0.0%         7.7%      |  75.4%        59.5%        28.6%        44.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    4/28 (14%)   0/22 (0%)    1/18 (6%)  | 24/34 (71%)  15/31 (48%)   6/32 (19%)   9/28 (32%) |
|FIRST INCIDENCE (DAYS) |   625          729 (T)      ---          555       |   673          372          626          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372N     P=0.615N     P=0.097N     P=0.501N   |  P=0.024N*    P=0.338N     P<0.001N**   P=0.041N*  |
|INCIDENTAL TUMOR       |  P=0.348N     P=0.496      P=0.160N     P=0.542N   |  P=0.004N**   P=0.176N     P<0.001N**   P=0.005N** |
|LOGISTIC REGRESSION    |  P=0.343N     P=0.605      P=0.110N     P=0.502N   |  P=0.006N**   P=0.232N     P<0.001N**   P=0.011N*  |
|COCHRAN-ARMITAGE       |  P=0.332N                                          |  P=0.003N**                                        |
|FISHER EXACT           |               P=0.500      P=0.122N     P=0.508N   |               P=0.180N     P<0.001N**   P=0.004N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    0/60 (0%)    2/59 (3%)  | 32/60 (53%)  25/60 (42%)  11/60 (18%)  16/60 (27%) |
|ADJUSTED (b)           |  11.0%        14.3%         0.0%         7.7%      |  77.8%        59.5%        28.6%        44.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    4/28 (14%)   0/22 (0%)    1/18 (6%)  | 25/34 (74%)  15/31 (48%)   6/32 (19%)   9/28 (32%) |
|FIRST INCIDENCE (DAYS) |   625          729 (T)      ---          555       |   673          372          626          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372N     P=0.615N     P=0.097N     P=0.501N   |  P=0.018N*    P=0.279N     P<0.001N**   P=0.028N*  |
|INCIDENTAL TUMOR       |  P=0.348N     P=0.496      P=0.160N     P=0.542N   |  P=0.002N**   P=0.130N     P<0.001N**   P=0.003N** |
|LOGISTIC REGRESSION    |  P=0.343N     P=0.605      P=0.110N     P=0.502N   |  P=0.004N**   P=0.176N     P<0.001N**   P=0.006N** |
|COCHRAN-ARMITAGE       |  P=0.332N                                          |  P=0.002N**                                        |
|FISHER EXACT           |               P=0.500      P=0.122N     P=0.508N   |               P=0.136N     P<0.001N**   P=0.002N** |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  11
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/59 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          627          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.708        (e)        P=0.297        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.672N       (e)        P=0.222        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.713        (e)        P=0.251        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.713                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    1/60 (2%)    0/59 (0%)  |  2/60 (3%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.3%         8.7%         4.2%         0.0%      |   5.9%         0.0%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  2/34 (6%)    0/31 (0%)    2/32 (6%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   688          449 (I)      723          ---       |   729 (T)      ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.222N     P=0.419      P=0.705N     P=0.500N   |  P=0.288N     P=0.259N     P=0.674      P=0.282N   |
|INCIDENTAL TUMOR       |  P=0.190N     P=0.395      P=0.693N     P=0.452N   |  P=0.288N     P=0.259N     P=0.674      P=0.282N   |
|LOGISTIC REGRESSION    |  P=0.203N     P=0.320      P=0.725N     P=0.501N   |  P=0.288N     P=0.259N     P=0.674      P=0.282N   |
|COCHRAN-ARMITAGE       |  P=0.202N                                          |  P=0.250N                                          |
|FISHER EXACT           |               P=0.309      P=0.752N     P=0.504N   |               P=0.248N     P=0.691N     P=0.248N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  12
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    1/60 (2%)    0/59 (0%)  |  3/60 (5%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.3%         8.7%         4.2%         0.0%      |   7.9%         0.0%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  2/34 (6%)    0/31 (0%)    2/32 (6%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   688          449 (I)      723          ---       |   623          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.222N     P=0.419      P=0.705N     P=0.500N   |  P=0.168N     P=0.138N     P=0.530N     P=0.159N   |
|INCIDENTAL TUMOR       |  P=0.190N     P=0.395      P=0.693N     P=0.452N   |  P=0.118N     P=0.047N*    P=0.387N     P=0.046N*  |
|LOGISTIC REGRESSION    |  P=0.203N     P=0.320      P=0.725N     P=0.501N   |  P=0.156N     P=0.128N     P=0.527N     P=0.134N   |
|COCHRAN-ARMITAGE       |  P=0.202N                                          |  P=0.138N                                          |
|FISHER EXACT           |               P=0.309      P=0.752N     P=0.504N   |               P=0.122N     P=0.500N     P=0.122N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/57 (4%)    0/55 (0%)    0/57 (0%)    1/56 (2%)  |  0/58 (0%)    0/58 (0%)    0/56 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.1%         0.0%         0.0%         5.9%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   0/26 (0%)    0/22 (0%)    1/17 (6%)  |  0/34 (0%)    0/30 (0%)    0/31 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          ---          729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.619N     P=0.161N     P=0.194N     P=0.520N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.619N     P=0.161N     P=0.194N     P=0.520N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.619N     P=0.161N     P=0.194N     P=0.520N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.563N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.257N     P=0.248N     P=0.507N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  13
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pharynx                                                                                                                          |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/59 (0%)  |  1/60 (2%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         5.2%         0.0%         0.0%      |   2.9%         0.0%         6.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/28 (4%)    0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    2/32 (6%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          449 (I)      ---          ---       |   729 (T)      ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.442N     P=0.288        (e)          (e)      |  P=0.482N     P=0.518N     P=0.479      P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.442N     P=0.288        (e)          (e)      |  P=0.482N     P=0.518N     P=0.479      P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.429N     P=0.226        (e)          (e)      |  P=0.482N     P=0.518N     P=0.479      P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.428N                                          |  P=0.438N                                          |
|FISHER EXACT           |               P=0.248        (e)          (e)      |               P=0.500N     P=0.500      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  12/59 (20%)  13/60 (22%)  10/59 (17%) | 30/59 (51%)  16/60 (27%)  17/60 (28%)  18/59 (31%) |
|ADJUSTED (b)           |  44.9%        33.2%        44.3%        33.7%      |  70.0%        40.3%        41.4%        49.2%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   1/7 (14%)    0/10 (0%)  |  3/10 (30%)   1/10 (10%)   0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  3/18 (17%)   7/28 (25%)   8/22 (36%)   3/18 (17%) | 21/33 (64%)   9/31 (29%)   9/32 (28%)  11/28 (39%) |
|FIRST INCIDENCE (DAYS) |   449 (I)      449 (I)      416          555       |   450 (I)      450 (I)      481          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.288N     P=0.110N     P=0.268N     P=0.201N   |  P=0.187N     P=0.019N*    P=0.027N*    P=0.089N   |
|INCIDENTAL TUMOR       |  P=0.172N     P=0.392N     P=0.359N     P=0.151N   |  P=0.092N     P=0.011N*    P=0.016N*    P=0.025N*  |
|LOGISTIC REGRESSION    |  P=0.202N     P=0.283N     P=0.359N     P=0.169N   |  P=0.095N     P=0.007N**   P=0.012N*    P=0.029N*  |
|COCHRAN-ARMITAGE       |  P=0.195N                                          |  P=0.070N                                          |
|FISHER EXACT           |               P=0.349N     P=0.415N     P=0.197N   |               P=0.006N**   P=0.010N**   P=0.019N*  |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  14
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  12/59 (20%)  13/60 (22%)  10/59 (17%) | 30/59 (51%)  16/60 (27%)  17/60 (28%)  19/59 (32%) |
|ADJUSTED (b)           |  44.9%        33.2%        44.3%        33.7%      |  70.0%        40.3%        41.4%        51.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   1/7 (14%)    0/10 (0%)  |  3/10 (30%)   1/10 (10%)   0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  3/18 (17%)   7/28 (25%)   8/22 (36%)   3/18 (17%) | 21/33 (64%)   9/31 (29%)   9/32 (28%)  11/28 (39%) |
|FIRST INCIDENCE (DAYS) |   449 (I)      449 (I)      416          555       |   450 (I)      450 (I)      481          450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.288N     P=0.110N     P=0.268N     P=0.201N   |  P=0.254N     P=0.019N*    P=0.027N*    P=0.130N   |
|INCIDENTAL TUMOR       |  P=0.172N     P=0.392N     P=0.359N     P=0.151N   |  P=0.139N     P=0.011N*    P=0.016N*    P=0.042N*  |
|LOGISTIC REGRESSION    |  P=0.202N     P=0.283N     P=0.359N     P=0.169N   |  P=0.141N     P=0.007N**   P=0.012N*    P=0.046N*  |
|COCHRAN-ARMITAGE       |  P=0.195N                                          |  P=0.105N                                          |
|FISHER EXACT           |               P=0.349N     P=0.415N     P=0.197N   |               P=0.006N**   P=0.010N**   P=0.031N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    2/60 (3%)    1/60 (2%)    3/59 (5%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  13.9%         7.1%         3.3%         8.8%      |   2.2%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   533          729 (T)      695          539       |   651          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.579N     P=0.218N     P=0.131N     P=0.500N   |  P=0.419N     P=0.518N     P=0.528N     P=0.538N   |
|INCIDENTAL TUMOR       |  P=0.525N     P=0.326N     P=0.151N     P=0.515N   |  P=0.420N     P=0.517N     P=0.557N     P=0.536N   |
|LOGISTIC REGRESSION    |  P=0.549N     P=0.294N     P=0.167N     P=0.507N   |  P=0.394N     P=0.499N     P=0.499N     P=0.499N   |
|COCHRAN-ARMITAGE       |  P=0.543N                                          |  P=0.394N                                          |
|FISHER EXACT           |               P=0.340N     P=0.182N     P=0.509N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  15
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    1/60 (2%)    4/60 (7%)    2/59 (3%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  20.9%         3.6%        13.1%         8.5%      |   2.9%         3.2%         0.0%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/18 (17%)   1/28 (4%)    0/22 (0%)    1/18 (6%)  |  1/34 (3%)    1/31 (3%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   533          729 (T)      688          649       |   729 (T)      729 (T)      ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.339N     P=0.046N*    P=0.368N     P=0.211N   |  P=0.642      P=0.741      P=0.512N     P=0.718    |
|INCIDENTAL TUMOR       |  P=0.274N     P=0.080N     P=0.393N     P=0.224N   |  P=0.642      P=0.741      P=0.512N     P=0.718    |
|LOGISTIC REGRESSION    |  P=0.310N     P=0.077N     P=0.433N     P=0.217N   |  P=0.642      P=0.741      P=0.512N     P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.297N                                          |  P=0.679                                           |
|FISHER EXACT           |               P=0.103N     P=0.500N     P=0.226N   |               P=0.752N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    2/60 (3%)    4/60 (7%)    2/59 (3%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  20.9%         5.9%        13.1%         8.5%      |   2.9%         3.2%         0.0%         3.6%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/18 (17%)   1/28 (4%)    0/22 (0%)    1/18 (6%)  |  1/34 (3%)    1/31 (3%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   533          625          688          649       |   729 (T)      729 (T)      ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.292N     P=0.116N     P=0.368N     P=0.211N   |  P=0.642      P=0.741      P=0.512N     P=0.718    |
|INCIDENTAL TUMOR       |  P=0.229N     P=0.245N     P=0.393N     P=0.224N   |  P=0.642      P=0.741      P=0.512N     P=0.718    |
|LOGISTIC REGRESSION    |  P=0.262N     P=0.178N     P=0.433N     P=0.217N   |  P=0.642      P=0.741      P=0.512N     P=0.718    |
|COCHRAN-ARMITAGE       |  P=0.254N                                          |  P=0.679                                           |
|FISHER EXACT           |               P=0.219N     P=0.500N     P=0.226N   |               P=0.752N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  16
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/59 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         5.9%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/28 (4%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          625          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.450N     P=0.310        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.429N     P=0.148        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.433N     P=0.261        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.428N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    1/60 (2%)    2/59 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.2%         3.6%         3.3%         6.1%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    1/28 (4%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   678          729 (T)      695          539       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.326      P=0.677N     P=0.683N     P=0.505    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.379      P=0.702N     P=0.693N     P=0.535    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.345      P=0.717N     P=0.737N     P=0.496    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.352                                           |    (e)                                             |
|FISHER EXACT           |               P=0.752N     P=0.752N     P=0.494    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  17
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    0/60 (0%)    1/59 (2%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   7.7%         3.6%         0.0%         2.9%      |   2.2%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    1/28 (4%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   533          729 (T)      ---          621       |   651          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.473N     P=0.399N     P=0.213N     P=0.498N   |  P=0.419N     P=0.518N     P=0.528N     P=0.538N   |
|INCIDENTAL TUMOR       |  P=0.469N     P=0.419N     P=0.202N     P=0.539N   |  P=0.420N     P=0.517N     P=0.557N     P=0.536N   |
|LOGISTIC REGRESSION    |  P=0.454N     P=0.473N     P=0.235N     P=0.504N   |  P=0.394N     P=0.499N     P=0.499N     P=0.499N   |
|COCHRAN-ARMITAGE       |  P=0.452N                                          |  P=0.394N                                          |
|FISHER EXACT           |               P=0.500N     P=0.248N     P=0.506N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    2/60 (3%)    1/60 (2%)    3/59 (5%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.5%         7.1%         3.3%         8.8%      |   2.2%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   533          729 (T)      695          539       |   651          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.497      P=0.357N     P=0.231N     P=0.654N   |  P=0.419N     P=0.518N     P=0.528N     P=0.538N   |
|INCIDENTAL TUMOR       |  P=0.540      P=0.390N     P=0.225N     P=0.660    |  P=0.420N     P=0.517N     P=0.557N     P=0.536N   |
|LOGISTIC REGRESSION    |  P=0.523      P=0.445N     P=0.284N     P=0.657    |  P=0.394N     P=0.499N     P=0.499N     P=0.499N   |
|COCHRAN-ARMITAGE       |  P=0.528                                           |  P=0.394N                                          |
|FISHER EXACT           |               P=0.500N     P=0.309N     P=0.652    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  18
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    2/60 (3%)    1/60 (2%)    3/59 (5%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.5%         7.1%         3.3%         8.8%      |   2.2%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   533          729 (T)      695          539       |   651          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.497      P=0.357N     P=0.231N     P=0.654N   |  P=0.419N     P=0.518N     P=0.528N     P=0.538N   |
|INCIDENTAL TUMOR       |  P=0.540      P=0.390N     P=0.225N     P=0.660    |  P=0.420N     P=0.517N     P=0.557N     P=0.536N   |
|LOGISTIC REGRESSION    |  P=0.523      P=0.445N     P=0.284N     P=0.657    |  P=0.394N     P=0.499N     P=0.499N     P=0.499N   |
|COCHRAN-ARMITAGE       |  P=0.528                                           |  P=0.394N                                          |
|FISHER EXACT           |               P=0.500N     P=0.309N     P=0.652    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 52/60 (87%)  52/59 (88%)  53/60 (88%)  50/59 (85%) |                                                    |
|ADJUSTED (b)           | 100.0%        98.0%       100.0%       100.0%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   8/10 (80%)   6/7 (86%)    6/10 (60%) |                                                    |
|TERMINAL (d)           | 18/18 (100%) 26/27 (96%)  22/22 (100%) 18/18 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   418          416          449 (I)      441       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.364      P=0.038N*    P=0.278N     P=0.436N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.275N     P=0.621N     P=0.546N     P=0.360N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.326N     P=0.612      P=0.605      P=0.406N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.388N                                          |                                                    |
|FISHER EXACT           |               P=0.514      P=0.500      P=0.485N   |                                                    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  19
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    3/60 (5%)    8/60 (13%)   3/59 (5%)  |  3/59 (5%)    2/59 (3%)    8/60 (13%)   8/60 (13%) |
|ADJUSTED (b)           |  21.7%         9.5%        26.7%        12.7%      |   8.0%         6.7%        22.8%        24.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   1/28 (4%)    3/22 (14%)   2/18 (11%) |  2/34 (6%)    2/30 (7%)    6/32 (19%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   632          676          466          449 (I)   |   663          729 (T)      598          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.463N     P=0.187N     P=0.421      P=0.360N   |  P=0.019 *    P=0.554N     P=0.084      P=0.061    |
|INCIDENTAL TUMOR       |  P=0.355N     P=0.314N     P=0.415      P=0.336N   |  P=0.031 *    P=0.545N     P=0.113      P=0.093    |
|LOGISTIC REGRESSION    |  P=0.403N     P=0.249N     P=0.352      P=0.357N   |  P=0.025 *    P=0.540N     P=0.089      P=0.075    |
|COCHRAN-ARMITAGE       |  P=0.386N                                          |  P=0.041 *                                         |
|FISHER EXACT           |               P=0.359N     P=0.279      P=0.368N   |               P=0.500N     P=0.107      P=0.107    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/59 (2%)  |  0/59 (0%)    2/59 (3%)    0/60 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         3.0%      |   0.0%         6.7%         0.0%         6.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    2/30 (7%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          633       |   ---          729 (T)      ---          620       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.199        (e)          (e)        P=0.519    |  P=0.210      P=0.211        (e)        P=0.202    |
|INCIDENTAL TUMOR       |  P=0.250        (e)          (e)        P=0.469    |  P=0.284      P=0.211        (e)        P=0.393    |
|LOGISTIC REGRESSION    |  P=0.208        (e)          (e)        P=0.498    |  P=0.232      P=0.211        (e)        P=0.233    |
|COCHRAN-ARMITAGE       |  P=0.208                                           |  P=0.255                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.496    |               P=0.248        (e)        P=0.252    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  20
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    3/60 (5%)    8/60 (13%)   4/59 (7%)  |  3/59 (5%)    4/59 (7%)    8/60 (13%)   9/60 (15%) |
|ADJUSTED (b)           |  21.7%         9.5%        26.7%        15.3%      |   8.0%        13.3%        22.8%        26.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/18 (11%)   1/28 (4%)    3/22 (14%)   2/18 (11%) |  2/34 (6%)    4/30 (13%)   6/32 (19%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   632          676          466          449 (I)   |   663          729 (T)      598          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.535      P=0.187N     P=0.421      P=0.495N   |  P=0.017 *    P=0.434      P=0.084      P=0.036 *  |
|INCIDENTAL TUMOR       |  P=0.504N     P=0.314N     P=0.415      P=0.488N   |  P=0.034 *    P=0.442      P=0.113      P=0.085    |
|LOGISTIC REGRESSION    |  P=0.559N     P=0.249N     P=0.352      P=0.502N   |  P=0.024 *    P=0.445      P=0.089      P=0.048 *  |
|COCHRAN-ARMITAGE       |  P=0.537N                                          |  P=0.040 *                                         |
|FISHER EXACT           |               P=0.359N     P=0.279      P=0.511N   |               P=0.500      P=0.107      P=0.067    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    3/60 (5%)    1/60 (2%)    0/59 (0%)  |  0/59 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         8.7%         3.6%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    2/28 (7%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/30 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          449 (I)      698          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372N     P=0.177      P=0.557        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.348N     P=0.177      P=0.562        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.349N     P=0.123      P=0.530        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.348N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.122      P=0.500        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  21
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    2/60 (3%)    1/59 (2%)  |  0/59 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.6%         8.7%         7.8%         5.6%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    2/28 (7%)    0/22 (0%)    1/18 (6%)  |  0/34 (0%)    0/30 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      449 (I)      698          729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.520N     P=0.429      P=0.572      P=0.763    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.471N     P=0.429      P=0.595      P=0.763    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.480N     P=0.328      P=0.575      P=0.763    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.466N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.309      P=0.500      P=0.748    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/60 (3%)    5/60 (8%)   10/60 (17%)   9/60 (15%) |
|ADJUSTED (b)           |                                                    |   5.9%        14.9%        25.6%        24.5%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  2/34 (6%)    4/31 (13%)   6/32 (19%)   2/28 (7%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   729 (T)      626          450 (I)      591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.017 *    P=0.183      P=0.014 *    P=0.015 *  |
|INCIDENTAL TUMOR       |                                                    |  P=0.034 *    P=0.262      P=0.017 *    P=0.018 *  |
|LOGISTIC REGRESSION    |                                                    |  P=0.025 *    P=0.185      P=0.015 *    P=0.019 *  |
|COCHRAN-ARMITAGE       |                                                    |  P=0.033 *                                         |
|FISHER EXACT           |                                                    |               P=0.219      P=0.015 *    P=0.027 *  |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  22
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/60 (3%)    6/60 (10%)  10/60 (17%)  10/60 (17%) |
|ADJUSTED (b)           |                                                    |   5.9%        16.7%        25.6%        27.4%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |                                                    |  2/34 (6%)    4/31 (13%)   6/32 (19%)   3/28 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   729 (T)      590          450 (I)      591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.011 *    P=0.114      P=0.014 *    P=0.008 ** |
|INCIDENTAL TUMOR       |                                                    |  P=0.027 *    P=0.231      P=0.017 *    P=0.009 ** |
|LOGISTIC REGRESSION    |                                                    |  P=0.017 *    P=0.120      P=0.015 *    P=0.010 ** |
|COCHRAN-ARMITAGE       |                                                    |  P=0.023 *                                         |
|FISHER EXACT           |                                                    |               P=0.136      P=0.015 *    P=0.015 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/60 (50%)  36/60 (60%)  34/60 (57%)  33/59 (56%) | 18/60 (30%)  18/60 (30%)  22/60 (37%)  20/60 (33%) |
|ADJUSTED (b)           |  78.6%        79.5%        81.5%        73.9%      |  41.8%        43.5%        51.6%        48.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 11/18 (61%)  19/28 (68%)  15/22 (68%)   7/18 (39%) | 10/34 (29%)   8/31 (26%)  12/32 (38%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |   467          352          477          423       |   453          604          481          452       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.261      P=0.319N     P=0.445N     P=0.407    |  P=0.192      P=0.448      P=0.226      P=0.222    |
|INCIDENTAL TUMOR       |  P=0.468      P=0.094      P=0.372      P=0.349    |  P=0.363      P=0.551      P=0.210      P=0.412    |
|LOGISTIC REGRESSION    |  P=0.515      P=0.165      P=0.222      P=0.362    |  P=0.407      P=0.529N     P=0.288      P=0.475    |
|COCHRAN-ARMITAGE       |  P=0.412                                           |  P=0.370                                           |
|FISHER EXACT           |               P=0.179      P=0.292      P=0.321    |               P=0.579N     P=0.281      P=0.422    |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  23
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    0/60 (0%)    1/59 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  10.5%         3.6%         0.0%         1.8%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/18 (6%)    1/28 (4%)    0/22 (0%)    0/18 (0%)  |  0/34 (0%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   726          729 (T)      ---          449 (I)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.486N     P=0.355N     P=0.202N     P=0.506N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.454N     P=0.389N     P=0.186N     P=0.472N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.455N     P=0.371N     P=0.192N     P=0.504N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.452N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.248N     P=0.506N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/59 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.7%         0.0%      |   2.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          466          ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.713        (e)        P=0.273        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.710N       (e)        P=0.292        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.708        (e)        P=0.220        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.713                                           |  P=0.394N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  24
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/59 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.7%         0.0%      |   2.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/18 (0%)    0/28 (0%)    0/22 (0%)    0/18 (0%)  |  1/34 (3%)    0/31 (0%)    0/32 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          466          ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.713        (e)        P=0.273        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|INCIDENTAL TUMOR       |  P=0.710N       (e)        P=0.292        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|LOGISTIC REGRESSION    |  P=0.708        (e)        P=0.220        (e)      |  P=0.418N     P=0.518N     P=0.512N     P=0.539N   |
|COCHRAN-ARMITAGE       |  P=0.713                                           |  P=0.394N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 56/60 (93%)  56/60 (93%)  57/60 (95%)  53/59 (90%) | 45/60 (75%)  37/60 (62%)  37/60 (62%)  39/60 (65%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  93.6%        79.7%        80.1%        88.5%      |
|INTERIM SACRIFICE 1 (c)|  7/10 (70%)   9/10 (90%)   7/7 (100%)   7/10 (70%) |  3/10 (30%)   2/10 (20%)   1/10 (10%)   1/10 (10%) |
|TERMINAL (d)           | 18/18 (100%) 28/28 (100%) 22/22 (100%) 18/18 (100%)| 31/34 (91%)  22/31 (71%)  23/32 (72%)  23/28 (82%) |
|FIRST INCIDENCE (DAYS) |   418          416          416          441       |   450 (I)      372          450 (I)      450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.396      P=0.024N*    P=0.288N     P=0.392N   |  P=0.362      P=0.283N     P=0.232N     P=0.464    |
|INCIDENTAL TUMOR       |  P=0.110N     P=0.641N     P=0.623N     P=0.221N   |  P=0.374N     P=0.092N     P=0.117N     P=0.287N   |
|LOGISTIC REGRESSION    |  P=0.139N     P=0.628N     P=0.338      P=0.236N   |  P=0.404N     P=0.099N     P=0.104N     P=0.270N   |
|COCHRAN-ARMITAGE       |  P=0.262N                                          |  P=0.268N                                          |
|FISHER EXACT           |               P=0.641N     P=0.500      P=0.361N   |               P=0.085N     P=0.085N     P=0.160N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  25
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        500 PPM      1000 PPM     2500 PPM  |   0 PPM        500 PPM      1000 PPM     2500 PPM  |
|                       |   65 PATH      65 PATH      65 PATH      65 PATH   |   65 PATH      65 PATH      65 PATH      65 PATH   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 37/60 (62%)  41/60 (68%)  41/60 (68%)  37/59 (63%) | 22/60 (37%)  23/60 (38%)  24/60 (40%)  25/60 (42%) |
|ADJUSTED (b)           |  87.2%        85.2%        84.8%        80.1%      |  49.0%        51.5%        54.0%        56.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/7 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           | 13/18 (72%)  21/28 (75%)  15/22 (68%)   9/18 (50%) | 12/34 (35%)  10/31 (32%)  12/32 (38%)  10/28 (36%) |
|FIRST INCIDENCE (DAYS) |   418          352          403          423       |   453          428          481          452       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.377      P=0.168N     P=0.404N     P=0.537N   |  P=0.155      P=0.370      P=0.341      P=0.164    |
|INCIDENTAL TUMOR       |  P=0.381N     P=0.205      P=0.476      P=0.559N   |  P=0.396      P=0.546      P=0.362      P=0.498    |
|LOGISTIC REGRESSION    |  P=0.379N     P=0.427      P=0.254      P=0.565N   |  P=0.432      P=0.571N     P=0.480      P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.484N                                          |  P=0.323                                           |
|FISHER EXACT           |               P=0.283      P=0.283      P=0.529    |               P=0.500      P=0.426      P=0.354    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 56/60 (93%)  58/60 (97%)  59/60 (98%)  56/59 (95%) | 50/60 (83%)  47/60 (78%)  44/60 (73%)  48/60 (80%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  96.1%        90.3%        88.0%        96.0%      |
|INTERIM SACRIFICE 1 (c)|  7/10 (70%)   9/10 (90%)   7/7 (100%)   7/10 (70%) |  3/10 (30%)   2/10 (20%)   1/10 (10%)   1/10 (10%) |
|TERMINAL (d)           | 18/18 (100%) 28/28 (100%) 22/22 (100%) 18/18 (100%)| 32/34 (94%)  26/31 (84%)  26/32 (81%)  26/28 (93%) |
|FIRST INCIDENCE (DAYS) |   418          352          403          423       |   450 (I)      372          450 (I)      450 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.270      P=0.048N*    P=0.383N     P=0.538N   |  P=0.191      P=0.497      P=0.371N     P=0.203    |
|INCIDENTAL TUMOR       |  P=0.562N     P=0.347      P=0.385      P=0.683    |  P=0.360N     P=0.240N     P=0.098N     P=0.329N   |
|LOGISTIC REGRESSION    |  P=0.516N     P=0.370      P=0.167      P=0.669N   |  P=0.375N     P=0.385N     P=0.164N     P=0.348N   |
|COCHRAN-ARMITAGE       |  P=0.543                                           |  P=0.450N                                          |
|FISHER EXACT           |               P=0.340      P=0.182      P=0.509    |               P=0.322N     P=0.134N     P=0.407N   |
|=================================================================================================================================|
         DATE: 11/09/95                     EXPERIMENT: 05165 TEST: 01                                                 PAGE  26
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)

                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   449
          Female interim sacrifices(days): 450
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).